GCA_049524535.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaMEHHGLLO_2 (original name was: gnl|Prokka|MEHHGLLO_2)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	T3PKS	129,102	156,161

gnlProkkaMEHHGLLO_3 (original name was: gnl|Prokka|MEHHGLLO_3)

Region	Type	From	To	Most similar known cluster		Similarity
Region 3.1	cyclic-lactone-autoinducer	103,319	113,808

gnlProkkaMEHHGLLO_66 (original name was: gnl|Prokka|MEHHGLLO_66)

Region	Type	From	To	Most similar known cluster		Similarity
Region 66.1	lanthipeptide-class-iii	1	13,841

gnlProkkaMEHHGLLO_90 (original name was: gnl|Prokka|MEHHGLLO_90)

Region	Type	From	To	Most similar known cluster		Similarity
Region 90.1	terpene	1	8,440

gnlProkkaMEHHGLLO_144 (original name was: gnl|Prokka|MEHHGLLO_144)

Region	Type	From	To	Most similar known cluster		Similarity
Region 144.1	cyclic-lactone-autoinducer	1	2,619

gnlProkkaMEHHGLLO_147 (original name was: gnl|Prokka|MEHHGLLO_147)

Region	Type	From	To	Most similar known cluster		Similarity
Region 147.1	RiPP-like	1	2,536

Region	Type	From	To	Similarity
Region 2.1	T3PKS	129,102	156,161
Region 3.1	cyclic-lactone-autoinducer	103,319	113,808
Region 66.1	lanthipeptide-class-iii	1	13,841
Region 90.1	terpene	1	8,440
Region 144.1	cyclic-lactone-autoinducer	1	2,619
Region 147.1	RiPP-like	1	2,536

Compact view

gnlProkkaMEHHGLLO_2 - Region 1 - T3PKS

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Location: 129,102 - 156,161 nt. (total: 27,060 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

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Gene overview

NRPS/PKS domains

KnownClusterBlast

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaMEHHGLLO_3 - Region 1 - cyclic-lactone-autoinducer

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Location: 103,319 - 113,808 nt. (total: 10,490 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaMEHHGLLO_66 - Region 1 - lanthipeptide-class-iii

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Location: 1 - 13,841 nt. (total: 13,841 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-iii: (micKC and not PKS_KS)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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resistance

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Gene overview

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
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Similar known gene clusters from MIBiG 3.1

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Lanthipeptide predictions

Lanthipeptide(s) for ctg66_7

ctg66_3

Leader:

MMNKKILSLQKLETRSRIGKK

Core:

NSFISIACVDGSTVSLFACPGNPIKP

Core with dehydrations:

NDhaFIDhaIACysVDGDhaDhbVDhaLFACysPGNPIKP

MIBiG 3.1 matches for ctg66_3

15.4% BGC0000503 (cinA): Lanthipeptide: cinnamycin

17

FACPGN

22

F C GN

12

FVCDGN

17

antiSMASH-DB 4.0 matches for ctg66_3

38.5% NZ_JAOPTJ010000013.1: Lanthipeptides: OCF64_RS23350_lanthipeptide

4

ISIACVDGSTVSLFAC-PGN

22

+S C + ST+SLF C PG

3

LSFICKEKSTISLFTCLPGQ

22

38.5% NZ_JAOPTJ010000013.1: Lanthipeptides: OCF64_RS23365_lanthipeptide

2

SFISIACVDGSTVSLFAC-PGN

22

S +S+ C + ST+S+F C PG

1

SNLSLVCKEKSTISVFTCLPGQ

22

34.6% NC_013164.1: Lanthipeptides: APRE_RS09660_lanthipeptide

2

SFISIACVDGSTVSLFAC

19

S S C + S VSLF C

4

STYSTNCKNSSGVSLFIC

21

with 15 more sequence matches

34.6% NZ_CP017429.1: Lanthipeptides: BI282_RS13940_lanthipeptide

4

ISIACVDGSTVSLFAC

19

ISIAC S++S F+C

1

ISIACKKKSSISAFSC

16

34.6% NZ_JAMYIV010000006.1: Lanthipeptides: allorf_139780_139899_lanthipeptide

5

SIACVDGSTVSLFAC

19

SI C ST+SLF C

6

SINCKRKSTLSLFFC

20

34.6% NZ_QSNA01000006.1and 1 other:

NZ_VEAP01000011.1 Lanthipeptides: FS510_RS26445_lanthipeptide

Lanthipeptides: DX931_RS28505_lanthipeptide

4

ISIACVDGSTVSLFAC-PGN

22

+S C + ST+S+F C PG

3

LSFICKEKSTISVFTCLPGQ

22

31.0% NZ_CP095072.1: Lanthipeptides: MUN88_RS06690_lanthipeptide

11

GSTVSLFACPGNPI

24

ST S+FAC GN I

7

ASTASVFACFGNTI

20

30.8% NC_013164.1: Lanthipeptides: APRE_RS09840_lanthipeptide

5

SIACVDGSTVSLFAC

19

S C + S VSLF C

3

STNCKNSSGVSLFIC

17

30.8% NZ_AP018365.1: Lanthipeptides: RVR_RS03120_lanthipeptide

11

GSTVSLFAC

19

GSTVSL AC

3

GSTVSLAAC

11

30.8% NZ_CP024036.1: Lanthipeptides: CR091_RS27895_lanthipeptide

1

NSFISIACVDGSTVSLFAC

19

NS +S+ C S S F C

1

NSSLSLGCSPSSNTSWFLC

19

26.9% NC_013164.1: Lanthipeptides: APRE_RS09655_lanthipeptide

4

ISIACVDGSTVSLFAC

19

S C + S +SLF C

2

FSTNCKNSSGISLFVC

17

26.9% NZ_JACHIN010000006.1: Lanthipeptides: HNR40_RS24335_lanthipeptide

6

IACVDGSTVSLFACPG

21

+ C D ST+S+ C G

5

MMCGDSSTLSIMLCHG

20

26.9% NZ_JAOPTJ010000013.1and 2 others:

NZ_QSNA01000006.1 Lanthipeptides: allorf_108759_108914_lanthipeptideNZ_VEAP01000011.1 Lanthipeptides: allorf_058964_059119_lanthipeptide

Lanthipeptides: allorf_044284_044436_lanthipeptide

12

STVSLFACPGNPI

24

ST S F CP N +

3

STNSYFGCPNNTV

15

26.9% NZ_JAQQWS010000001.1: Lanthipeptides: PQ479_RS00990_lanthipeptide

4

ISIACVDGSTVSLFAC

19

+SI+C S++S+F C

2

LSISCKKFSSLSVFIC

17

26.9% NZ_VRLV01000003.1: Lanthipeptides: FVE25_RS14795_lanthipeptide

8

CVDGSTVSLFACPG

21

C D ST+S+ C G

7

CGDSSTLSVLLCHG

20

20.0% NZ_CP013141.1: Lanthipeptides: allorf_5323583_5323705_lanthipeptide

5

SIACVDGSTVSLFACPG

21

++ C T ACPG

1

AVGCRSARTGFFLACPG

17

20.0% NZ_CP113114.1and 1 other:

NZ_FZDV01000015.1 Lanthipeptides: CFW84_RS08635_lanthipeptide

Lanthipeptides: OTU45_RS07045_lanthipeptide

8

CVDGSTVSLFACPGNPIK

25

C G + CPGN I

7

CTPGCVTGVLMCPGNTIS

24

20.0% NZ_JALDTZ010000003.1: Lanthipeptides: M1F37_RS03135_lanthipeptide

8

CVDGSTVSLFACPGNPIK

25

C G + CPGN I

7

CTPGCVTGILMCPGNTIS

24

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg66_3 - Class III

Cleavage pHMM score: -0.80

RODEO score: 0

Monoisotopic mass: 2546.3 Da

Molecular weight: 2547.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2565.9 Da N = 1; 2584.0 Da N = 2; 2602.0 Da N = 3

gnlProkkaMEHHGLLO_90 - Region 1 - terpene

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Location: 1 - 8,440 nt. (total: 8,440 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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core biosynthetic genes

additional biosynthetic genes

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KnownClusterBlast

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
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Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaMEHHGLLO_144 - Region 1 - cyclic-lactone-autoinducer

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Location: 1 - 2,619 nt. (total: 2,619 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaMEHHGLLO_147 - Region 1 - RiPP-like

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Location: 1 - 2,536 nt. (total: 2,536 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.