LOCUS       gnlProkkaHKLMKOJD_66   13841 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HKLMKOJD_66.
ACCESSION   gnlProkkaHKLMKOJD_66
VERSION     gnlProkkaHKLMKOJD_66
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 23:52:38
            Original ID  :: gnl|Prokka|HKLMKOJD_66
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13841
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13841
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3857:6464]"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3858..6464
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     cand_cluster    1..13841
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13841
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     CDS             3..1952
                     /locus_tag="ctg66_1"
                     /transl_table=11
                     /translation="MWGQAIDHWSAPYQSDDYFAVGNIDFAIKLKPKPVAPTKPKAETA
                     SYQLTDLMVTPSNHKDVTAGDNQGKDTASINGKTVDKGDTLTYPLTNSDLPANRTDDIK
                     SYVLTDKVQKELRVNQAETVKANTKNWDVKVDCQTVTYTAKADLLKAMNADKSKAYAVP
                     EAKLFTTVNADNVTIKNQFNTKINDVTTDSNTPSNPVEKLSPSLVVKRVEDAQGKLATT
                     SDNVNILTGKDVYFDIFNQYDNNSHTDDLTDTDQLPKDAKVDTSKIKVMMSDGKADVFS
                     MTADKLTGLSYTKDVTSDVTIAYKDGKLTVTPKAGKEAEFKNQQTKVRFAASLPKEKAD
                     SQLTKQDGDYVWNNTATKGGTTSNKVNYNAEKDPDLITKKVETKDGKLADNVANANIIN
                     AKTVPFNIFNQYNNLGETQYMTDTDQLPKDAKVDLKAVKVYLADTTTTDTNSSAKADDQ
                     SSTTTSASSSAKTDDQSSTAMSTSSSSKADDQSSTATSASSSAKTDDQSTSKTSKIDAK
                     TMTKEKLTTLTYTKDVTADFTVKFENGKLTVTPKADKIAEYAGKQTKTRFVASLPTDKA
                     DSELTKQGQTYTWNNQASNGKDKTSTVKYHTDKPVTPAKPTTPAPKPTVTKVVKMAQTG
                     HHQTWFDRLVAWFK"
     CDS             2004..2324
                     /locus_tag="ctg66_2"
                     /transl_table=11
                     /translation="MAKIGGINMADNVLMAYHIVHDPDERAKHVLNTKKLYKWRITEKT
                     KGTPVVGNVALVQTQFAKRTPVMIYATKEVANDLSDLQPVKVFTNNRDQETVNQTFDDL
                     MK"
     CDS             2767..2910
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg66_3"
                     /transl_table=11
                     /translation="MMNKKILSLQKLETRSRIGKKNSFISIACVDGSTVSLFACPGNPI
                     KP"
     CDS_motif       2767..2829
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MMNKKILSLQKLETRSRIGKK"
                     /locus_tag="ctg66_3_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       2830..2910
                     /prepeptide="core"
                     /locus_tag="ctg66_3_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-0.80"
                     /molecular_weight="2547.9"
                     /monoisotopic_mass="2546.3"
                     /core_sequence="NSFISIACVDGSTVSLFACPGNPIKP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MMNKKILSLQKLETRSRIGKK"
                     /leader_location="[2766:2829](+)"
                     /alternative_weights="2565.9"
                     /alternative_weights="2584.0"
                     /alternative_weights="2602.0"
     CDS             2928..3068
                     /locus_tag="ctg66_4"
                     /transl_table=11
                     /translation="MRKITELQRLNESENGPALARMSTVSVALCAPKGHSIWSLASYFL
                     C"
     CDS             3085..3207
                     /locus_tag="ctg66_5"
                     /transl_table=11
                     /translation="MKKFIGLQALKLSHTEDTVARYSTISIGCAHRSNVSAYLC"
     CDS             3224..3829
                     /locus_tag="ctg66_6"
                     /transl_table=11
                     /translation="MIKIIFKDSNDTHEHFASANFIVAGGRQYLATAAHCFFNPVSHEM
                     AKDIRIETTIDGKPVYGNVTAVKIDSHWKNGGALQYDNAFCSFSFVEEIDPNCSDSLFD
                     YLPKENDFLSVEGISSGLFFNKRKKSVGHPDLSLLNSNWIIGIPAKMKQGVSGGPVFAK
                     VNGIDKQVGVISASFKETPNYVWCTVWNRDTYNLITSL"
     CDS             3858..6464
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 60.8;
                     E-value: 2.5e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_7"
                     /sec_met_domain="micKC (E-value: 1.4e-131, bitscore: 429.9,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.5e-17, bitscore: 53.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.7e-19, bitscore:
                     59.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIRYTEFLKKGTIFYAPTVKEQKPYKKPAVNPNDWILSEDKNWS
                     YYINQTNTLAKQGWKIHVTTTIKDSQKCLDVVSEYLIESQISFKFVPNIEMLLEKNSKY
                     GDRASAGKFITVYPKNTIEFVNTLKRLSQITNNFSSGPYILNDKQWYDSNIFFRYGAFR
                     EMYANVDGKRVLGIENSEGLMIPDIRAPYYVVPEFVQEPEEVISMTLTQNEKYNQLDTS
                     HFDKYEVKSALHFSNAGGVYKVTHDGKQFVMKEGRKESGLDRLNKDGFKRLKNEVSVLK
                     RLQTKEYVVNVHDYFEIWKNNYLIEDYLPGRNLSDFVAEEFPFSNFQNKNEYTLEALEI
                     IKKLKAILSDLHKEGISLGDLQPNNVMVLNNHDVMLIDLETATSTNKVYYPGLQTPGFV
                     LQNADSFEEADWFAMWRIARFLFLPIEPVGDLADDIEESQDISIEENFGEEVLDQLKDL
                     KAFIKKFGCKKNSNSFLSAANIQFKNFNLLKIKEHVRQGLLDNIDVNSESFIPGDIRQF
                     TDSMGAMSVAYGGFGSVMALKRTGELPLEARTWATHSARKILKLPYSSLPKGLFNGLAG
                     ISEVLFEIGEFDLALEIFKECAIDFNSDDLSVFSGASGVGLIALSLYEETGNVDLLNKA
                     LSIGKQTKQKFNHGLKLKSQDPFGIPNGLLGGWSGIGLFMLELSIATDNEEFKKIAIQM
                     VRKELDNNVSVDDNLRLAQVSDYSLGKERLIPYLGEGSVGIALVLLEFSKFTKSFNNSK
                     DQKMIEYLCNVDETYCSYTSGLTRGITGFIVLENAKKKLGFINDYSISTLRNYLLEDDK
                     HHIICPGDYGYRCSMDLFTGNSGLLLTLNDLNNDGWGNWFPVVPGSLSNLFGMKLK"
     CDS             6906..8537
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 104.4; E-value:
                     1.3e-31)"
                     /gene_kind="transport"
                     /locus_tag="ctg66_8"
                     /transl_table=11
                     /translation="MYFIKKLILKHKFGMLCSLLLMIVYSFNGVLISSLVYYAGKFNSK
                     TSARSIIIYLVLSLIAWVIIYLAQYLLSIVQSKILRDVNINLKGKVINNTWFSNGKHEN
                     SADVISLLMNDFKLLETNYLAEVFEMIENLLLLIVSLTYMLILNRLVSFIFIAFSFLPL
                     VTPMIFSKSLSLAATSWTKNNDELIAKVKDFYQGFSTFRTYGAQDRIYSLLHKKVVGVE
                     NGQYYLSVKQSGAQFAGSVVAGIGFIVPFSIGCMLIISTKSFTFTTLLAIFLANDRVIS
                     PVMNMVSSFNQMGSTKTIRENILKIIKNKPILPKNKAPENSCQSTHSSKVFEAKNMYFK
                     INKSKSISFDLRVEVNDKILIFGESGIGKSTLLKILNGDISADTGNYIERDRSGNILKN
                     PSDEVAYISQIPYIYKASMADNISLFDSEKQVKKLELSVIKARLTADYTLSDIFEMNLG
                     ENGSSLSGGQRQKIEIARALFANKSLILADEVTANLDNESANEIRKLLFELPQPVVEVA
                     HHYNMNDTRYTKVFNLQNNGVLVQIR"
     CDS             8672..9544
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 132.6; E-value:
                     3.1e-40)"
                     /gene_kind="transport"
                     /locus_tag="ctg66_9"
                     /transl_table=11
                     /translation="MKKSVLEVSSLTKSFNEKNILCNINLCAMKGDVVGLVGPNGVGKT
                     TLMKCILGLTNFYKGTIIFNGKEISSKSTGIGGLIENPGLYPFLSGMENIRMFANDVDD
                     DLLKRLIAIFKMEPYIMKRVSTYSLGMKQKIGIIQAISIGKKIVFLDEPLNGLDPQSVV
                     EFRDIVRELSAMGVTFFISSHLIGELERLADKIYILKRGGELEIFNINERDGNNWFEML
                     TTNNEMFTEKLYEASIFSYSLNTYVVVNLTTEEVTRKVFDIITTQRIEVKKIQQVNSDI
                     EAQILKKMK"
     CDS             9552..10301
                     /locus_tag="ctg66_10"
                     /transl_table=11
                     /translation="MITSIRLELYKFKKQKHVNVVLCGTIVFYFLMVALTIFKPGYFEK
                     KLMVENSFSTLQFLPLIIMIFASELMSAEFRLGTIKNLIVTSKSRLQIIASKFIFLLII
                     ILSLFLGILLLDIFISFFIFQESIQSTIMKYTLLWVFGTAIETLLLGSLVFFLSIIFKN
                     PAIPVTIGVLVYLLVGLVDGMNFHLISKLKFLRWNVLNLLNFKAQLIDHSLQNYTKLSL
                     TDFSIGISLYIIFFLMTSYVVFRDKTI"
     CDS             10316..10528
                     /locus_tag="ctg66_11"
                     /transl_table=11
                     /translation="MKHGFSLLNVFLLIMFIVLSTIIWLRRTDGSGAIQTTNLRWVNFI
                     ILLVFFMVLVVIELIVYIISLKTRK"
     CDS             11288..12028
                     /locus_tag="ctg66_12"
                     /transl_table=11
                     /translation="MAQNSGDPVLSAKDFVKENLADHQNVTSLYNAFKDYLNQQPDLQV
                     SKASLVALNGAKGYFQPNKIVIGGDLKTLYHEHAHSQLHGLKAAFKDRPRAYQETQAEA
                     VAYVAMKNIGVDTSNYSLGYMATWAKDKGVIHSALSEIQQVSNKVIELSDRLTKQLGLQ
                     EAPKEPEHDLKKQSDQALNKSYQGLQQQIKQATSPQQKVQFKNRLNDVRQESSKLTQKQ
                     LQAFAEQNPEIKQPDPESDRSMKR"
     CDS             complement(12498..13685)
                     /locus_tag="ctg66_13"
                     /transl_table=11
                     /translation="MKDNQAKYPQLRFNGFTDPWEQRKTKELCDISTGKGNTQDKVEDG
                     KYPFYVRSATIERSNEYLYDQEAVLTVGDGVGTGKVFHYVNGKYNLHQRVYRMFNFNHG
                     VSAKYFYHYFSKNFYRRVMSMTAKTSVDSVRMEMIADMKIKFPSPAEQETIVSVLDGVD
                     DLISFHQRKLAKLKKLKQGYLQKLFPKNGAKVPELRFAGFADAWEQRKLGEVGKTQSGI
                     GFPDAEQGGTEGVPFYKVSDMNKPGNEHEMVNANNYVNYEQLSRKKWKIIETVPAVIFA
                     KVGAAIMLNRKRLVTSPFLIDNNTMAYVFYGSWNIDFGKTLFETINLPRYAQVGALPSY
                     NGSDIESIEVTLPNKGEQVKLGAFFKSLDDTITLHQRKLEKLQELKKGYLQKMFC"
     CDS             complement(13675..13839)
                     /locus_tag="ctg66_14"
                     /transl_table=11
                     /translation="MEPEPEIDLDQVKADLKQLDEEISQNEQAFNELASQLVTTQVNDQ
                     SKPEAHNER"
ORIGIN
        1 atacgtgggg gcaagcgatt gaccattggt cagctcctta tcaatctgat gattattttg
       61 cggttggcaa tattgatttt gccatcaagc taaagcctaa accggtcgcc ccaaccaagc
      121 ctaaagcgga aacggctagt taccaattaa ctgatttgat ggtcacccca agtaatcata
      181 aagatgtcac tgccggtgat aatcagggga aggacacagc ttccattaat ggtaagaccg
      241 tggataaggg cgataccttg acttatccgc taaccaattc tgatttgcca gctaatcgaa
      301 ctgatgacat taagagttat gtgctgactg ataaggttca aaaagaactc agagtcaacc
      361 aggcggaaac cgtcaaagct aatactaaga attgggatgt taaggttgac tgtcaaacag
      421 tcacttatac cgctaaggcg gacttattaa aggcgatgaa tgccgataag agcaaggcct
      481 atgcggtacc agaagctaag ttattcacaa ccgtcaatgc cgacaatgtg accattaaga
      541 atcaattcaa tacgaagatc aatgatgtga ccacggattc aaacacgcca agtaacccag
      601 ttgagaagct ttcaccatca ttagtggtca agcgcgtgga agatgcccaa ggcaagctcg
      661 caacaacgag tgacaacgtt aatatcttga cgggtaagga cgtttacttt gatattttca
      721 atcagtacga taacaactca catactgacg atttaacaga taccgatcaa ttgccgaaag
      781 atgcgaaagt tgataccagt aagatcaagg tgatgatgag cgatgggaag gccgacgtct
      841 ttagcatgac ggctgataag ctcacggggc tgagttatac gaaagacgtg accagcgatg
      901 ttacgattgc ttataaggac ggtaagttaa ccgtgacgcc gaaagctggt aaggaagctg
      961 agtttaaaaa tcaacaaacg aaagtgcggt ttgcggcgag tctacctaag gaaaaagctg
     1021 atagtcaact aacgaagcaa gatggcgact acgtttggaa taacacggcg actaaaggtg
     1081 ggacgacgtc caacaaggtt aactacaatg ccgaaaaaga cccagatttg atcactaaaa
     1141 aggtcgaaac caaggacggc aagttagccg ataacgtggc caatgccaat attatcaacg
     1201 ccaaaaccgt gcctttcaac attttcaatc agtataacaa tctaggcgaa actcagtata
     1261 tgaccgatac tgatcaactg ccgaaagatg cgaaagttga tttgaaagcg gtgaaagtct
     1321 atctagctga taccacaaca accgatacca attcatcagc taaggccgat gaccagtctt
     1381 caaccacaac gagcgctagt tcgtcagcta agactgatga ccaatcctca actgcaatga
     1441 gcactagttc gtcatctaag gctgatgacc aatcctcaac cgcaacgagt gctagttcgt
     1501 cagctaaaac tgatgatcag tcaacatcaa agactagcaa gattgatgct aaaacaatga
     1561 ctaaggaaaa actaacgaca ttgacttaca ctaaagatgt gaccgctgat ttcacagtca
     1621 aatttgagaa cggtaagcta accgtgacgc ccaaagctga taaaatcgct gagtatgctg
     1681 gtaagcaaac caaaacacgc tttgtcgcca gtctcccaac tgacaaagct gatagtgagt
     1741 tgaccaagca aggccagacc tatacttgga ataaccaagc gtctaatggt aaagataaga
     1801 ccagtacggt taagtatcat accgataagc cggtaacccc ggccaaacca acgactccag
     1861 cgcctaagcc aacggttact aaagtagtta agatggccca gactggtcat caccaaactt
     1921 ggtttgatcg attggtggct tggttcaaat aattgctagt ctgagggttc agcacgtata
     1981 ctaaagatat taaggaatga ccgatggcca aaataggagg aatcaacatg gctgataatg
     2041 tgttaatggc ctatcatatt gtgcatgatc ctgatgagcg ggcaaaacat gttttgaata
     2101 cgaaaaagtt gtataagtgg cggattaccg aaaagacgaa gggcaccccg gtagttggta
     2161 atgtggcgtt agtccaaacc cagtttgcga agcgcacgcc agtgatgatt tatgcgacaa
     2221 aggaagttgc caatgattta agtgacttac aaccagttaa agtctttacc aacaatcgtg
     2281 atcaagagac ggttaatcaa acgtttgatg acctgatgaa ataacttaac ggcccatacc
     2341 aacgtgaaat aaatcatgtt ggtatgggcc attttttaat gatcaagctt tatatctaat
     2401 ttgtacataa atggaaaagc tccaagtcag ttactatcta tgaactgagt cgagtttaat
     2461 cgcacaatct agaatttgcc taagttaaaa tgaaaatttt cgcactataa cctcataaac
     2521 cccaaattaa tcattcttaa atggttagat ttcgtattac tatttaggaa aaactacttt
     2581 aggggatcta atttttgttc ggataaaata tagaatttgc cattacgatt gatttactat
     2641 aacgacatgg gaaagaactc tgttttatga tgtgagtatt aaattttaca gtgcaaaaaa
     2701 attgtgataa aacgatgata ggttgtgatt gtatttgatt tcagcactat attgagggga
     2761 ggaaaaatga tgaacaaaaa aattttgagt ttacaaaagt tagaaacccg aagcagaatt
     2821 ggtaaaaaaa actcattcat cagtattgca tgtgttgatg gtagtacggt aagtttattt
     2881 gcttgtcctg gaaacccaat taaaccataa ggactgataa gttaattatg agaaaaatta
     2941 cagaactgca acgtttaaat gaaagtgaaa acggaccggc cttagcaaga atgtctaccg
     3001 taagtgtggc actctgtgct ccaaaaggcc attcaatatg gagcttggct tcatactttc
     3061 tttgctaaca ggaggagatt tattatgaaa aagttcattg ggttacaagc acttaagctt
     3121 tcacatacag aagatacggt agctcgatat tcaacgataa gtattggatg tgcgcatcgc
     3181 agtaacgtta gcgcatatct atgttgatta aagagttttg agattgatta aaataatatt
     3241 caaagattct aatgatacac atgaacattt tgcttctgct aattttattg tggcaggtgg
     3301 tagacaatat ttggcaacgg cggcgcactg tttttttaat ccggtaagtc acgaaatggc
     3361 caaagatatt cgtattgaga caacaataga tggaaaacct gtttatggta atgtgacagc
     3421 cgtaaaaata gactctcatt ggaaaaatgg gggggcactt caatatgaca atgctttttg
     3481 ttctttcagt ttcgtagaag aaattgaccc taactgttct gattctttat ttgattatct
     3541 accaaaagag aatgattttc ttagcgttga aggaatatca tcagggttat tcttcaataa
     3601 gagaaaaaaa tctgttgggc atcccgattt atctctatta aatagtaatt ggataattgg
     3661 tatacctgca aaaatgaagc aaggggtctc tggggggcca gtatttgcga aagtgaatgg
     3721 tattgataag caggttggag tgattagtgc atctttcaag gaaactccaa attatgtttg
     3781 gtgtacggtc tggaatagag atacatataa tctcataaca agcctgtaaa taaaagtaat
     3841 tgaaggtaaa ttaaataatg gatattagat atacggaatt tcttaaaaag ggaacaattt
     3901 tctatgcccc aacagtgaaa gaacaaaaac cttataaaaa gccggcagtc aatccaaatg
     3961 attggatttt atctgaggac aaaaattgga gctattatat caaccaaacg aatactcttg
     4021 ctaagcaagg gtggaagata cacgtaacaa caacgataaa agatagtcaa aaatgccttg
     4081 atgttgtgag tgaatatcta attgagagtc aaatctcatt taagtttgtt cctaatatag
     4141 aaatgctctt agaaaaaaat tcaaaatatg gtgatcgtgc ttctgcagga aaattcataa
     4201 ctgtttatcc taaaaatact attgagtttg taaatactct aaagaggcta tctcagatta
     4261 caaacaattt cagttctggg ccttacattt tgaatgataa acaatggtat gattcgaata
     4321 ttttctttcg ctatggtgct tttagagaaa tgtatgcaaa tgttgatgga aaaagggttt
     4381 tagggattga aaattctgaa ggcttaatga ttccagacat tcgtgcacca tattatgtag
     4441 tgccagaatt tgttcaagag ccagaagaag ttatttccat gacgcttact caaaatgaaa
     4501 aatacaacca gctagatact tcacattttg ataaatatga agtcaagtct gcactacatt
     4561 ttagcaatgc tggtggtgtt tataaggtga cccatgacgg aaaacaattt gtaatgaaag
     4621 aaggcagaaa agagtcgggg ttagatcgtt taaataaaga cggattcaaa cgtttaaaaa
     4681 atgaagttag tgttttaaaa aggttacaaa cgaaagaata cgttgtaaat gttcatgact
     4741 attttgaaat ttggaaaaac aactatttaa ttgaagatta tttaccaggt agaaatttgt
     4801 ctgactttgt tgcagaagag tttccatttt caaactttca aaataaaaat gaatacactt
     4861 tagaagcact tgaaatcatt aaaaagctta aagctatttt gagtgatctt cataaagaag
     4921 gtatttctct tggcgatcta caaccaaata acgtcatggt attaaacaat catgacgtca
     4981 tgttgattga cttagaaacg gccacttcaa caaacaaagt gtattatcca ggattgcaga
     5041 ctcctggttt tgttttgcaa aatgccgatt catttgaaga agctgattgg tttgcaatgt
     5101 ggcgaattgc tagattctta tttttaccaa ttgagcccgt tggagatcta gcagatgata
     5161 ttgaagaaag ccaagatata tccattgaag aaaactttgg tgaggaggtt ttagatcaat
     5221 taaaagattt gaaagcattc attaaaaagt ttggatgtaa aaagaatagt aattcatttc
     5281 tgtctgccgc gaatattcaa ttcaaaaatt ttaatctttt aaaaataaaa gagcatgtaa
     5341 gacaaggact attagataat attgacgtta atagtgagtc atttattcca ggtgatattc
     5401 gtcaatttac cgattccatg ggagctatgt cagttgccta tggcggattc ggtagcgtaa
     5461 tggccttaaa acgaactggt gaattgccat tagaagcaag aacatgggct actcattctg
     5521 ctagaaaaat attaaaattg ccatactcta gcttaccaaa gggattattt aatggcttgg
     5581 cgggtatttc agaagtgttg tttgaaattg gtgagtttga ccttgctctg gaaattttta
     5641 aggagtgtgc tatcgacttt aattctgatg atttaagtgt gttttcaggt gcttccggtg
     5701 ttggcttaat tgctttatct ttatatgaag aaacaggaaa cgttgatttg ttaaacaaag
     5761 cattatcaat cggaaaacaa acaaagcaaa aatttaatca tggattaaaa ctcaagtcac
     5821 aagatccctt tggtattcct aatggtcttt taggaggatg gtcagggatt ggattattca
     5881 tgttagagct ttctattgca actgataatg aagaatttaa gaaaattgca attcaaatgg
     5941 ttcgaaagga attagacaac aatgtttcag ttgacgataa tttgcggctt gcacaagtat
     6001 ctgattattc actaggaaaa gagcgtttaa ttccttatct aggtgaagga tctgtaggaa
     6061 ttgcgttagt attattggaa ttttctaaat tcaccaagtc attcaacaat tcgaaagatc
     6121 aaaagatgat cgagtatttg tgcaatgttg atgaaacata ttgctcatat acttctgggt
     6181 taacacgtgg aattaccggg tttattgttc ttgaaaatgc caaaaaaaaa ttgggcttca
     6241 tcaatgacta tagtatttct acactacgta attacttatt agaagatgat aagcatcata
     6301 ttatttgccc tggcgactat ggatatcgat gctcaatgga cttatttact ggaaattcag
     6361 gcttgttgtt aaccctcaat gatttgaata acgacggctg gggtaattgg tttccagttg
     6421 tacccggaag tttgtcgaat ttatttggaa tgaagctcaa ataagtatag ttttaaaatg
     6481 gattatatta tcttttgatt gtttatttta taaatttgca tctgaatttt ggggataaag
     6541 gaggtgataa gatgaataaa ctgattagtt tacaaaagac agcaattgac aatgatgtaa
     6601 ctttgttaaa aggtggatct tcaaaaatca gtcttggttg tcacaatatc agtacaatta
     6661 gtctttattt ttgtgcctga aattggtcat aaaggagagg gtggaaatat gaacaaattg
     6721 attaagttgc aaaagacggc tattgaccac aatgttacct tgttaaaggg tggatcctca
     6781 aaaattagtc ttggttgtca caatatcagc acaattagtc tttacttttg tgcttagagt
     6841 aatattttct aggagagaga ttatatatct ctccctttta catagtatat gggaggcaag
     6901 catatatgta ttttattaaa aaattaattt taaaacataa atttgggatg ctttgttctc
     6961 tcttattaat gattgtgtat tcatttaatg gggttttaat ttcgtcatta gtttactatg
     7021 caggaaagtt caattccaaa acttcagcta ggtcaataat catttatcta gtcctttcgt
     7081 tgatagcatg ggtgataata tatcttgcac aatatttact ttctatagta caaagtaaga
     7141 tattaaggga cgtaaacatt aacttaaagg ggaaagtaat taataataca tggttttcaa
     7201 acggcaaaca tgaaaattcg gcagatgtca tctcactgtt aatgaatgac tttaaattgt
     7261 tagaaacgaa ttatttagca gaagtcttcg aaatgattga gaaccttctt ttgttaatag
     7321 tttcgctaac atacatgctt atactcaata gactggtttc gtttatattc attgcatttt
     7381 cttttcttcc tttagtaacc ccgatgatat tttccaaaag tttgagttta gcagcgacat
     7441 cttggacaaa aaataacgat gaattaatag caaaagtaaa agatttttat caggggtttt
     7501 caacgttcag aacatacgga gctcaggatc gaatctattc ccttctccac aaaaaggttg
     7561 ttggcgtaga aaatggacaa tattatctct ctgtaaaaca atcgggtgca caatttgctg
     7621 gttccgttgt tgcagggatt ggtttcatag tccctttttc aattggttgc atgctgataa
     7681 tttcaactaa atctttcact tttactacat tactagctat tttcctggca aatgaccgtg
     7741 taataagtcc agtcatgaac atggtttcta gttttaacca gatgggttcg actaaaacta
     7801 tcagggaaaa cattctcaaa attattaaaa acaaaccaat acttccaaaa aataaagctc
     7861 ctgaaaatag ttgtcaatca acccatagtt ccaaagtatt tgaagcaaaa aatatgtatt
     7921 ttaaaataaa caaaagtaag tctatatcct ttgatttgag agtagaggtt aatgataaaa
     7981 tactgatttt tggagaatct ggcattggca aaagcacact attgaaaatt ttgaatggcg
     8041 atatcagcgc agacactggt aactatatag agagggacag aagtggtaac attttgaaaa
     8101 atccaagtga cgaagtggcc tatataagcc aaattcctta tatatataaa gcaagtatgg
     8161 cagataacat atctcttttt gattctgaaa agcaagtgaa aaagctggag ctttctgtca
     8221 taaaagctcg tttaacagca gactatacgc tgtcagatat ttttgaaatg aatttaggag
     8281 aaaatggatc ttccctgtca gggggacaaa ggcaaaaaat tgaaatagct agggcattat
     8341 ttgcaaataa gtctttaata ttagctgatg aggtaacagc caatctagat aatgaaagcg
     8401 caaatgaaat tagaaaattg ctatttgaac tacctcaacc agttgttgag gtggcccatc
     8461 attacaatat gaatgataca aggtatacaa aagtgtttaa tcttcagaac aatggtgttt
     8521 tagttcaaat tagataatcc aaaacgtcga gggcagaaag cctatatcag ttaatcaaag
     8581 ttaatgatag ttattgttat gtggcaatca aaatacaaaa atttaacaag atccatagga
     8641 gtagtttata gaatgtgagg agaaggtttt tatgaaaaaa agtgtgttgg aggtttcttc
     8701 tctgacaaaa tcattcaacg agaaaaatat attatgcaat atcaatttat gtgcaatgaa
     8761 aggagacgtg gtcggactgg ttggcccaaa cggagttggt aagacaactt tgatgaagtg
     8821 tattctagga cttacgaatt tttataaagg taccattatt ttcaatggaa aagaaatatc
     8881 ttcaaaatcc actggaattg gagggcttat agaaaatccg ggcctatatc catttctttc
     8941 tggtatggag aatatcagga tgtttgctaa tgatgttgat gacgatctat tgaagagatt
     9001 aattgctata tttaaaatgg aaccatatat tatgaaaagg gtctctacct actccctagg
     9061 aatgaagcaa aagattggaa taatacaagc aatttctatt gggaaaaaaa ttgttttttt
     9121 ggacgaacca ctcaacggac tggatccgca gtcagttgtt gaatttcgtg atatagtacg
     9181 agagttatct gcaatgggag taactttctt tatttccagc catttaatag gtgaattaga
     9241 gagattagca gataaaattt atattcttaa aaggggtggt gaacttgaga tatttaatat
     9301 aaatgagcga gatggaaaca attggtttga aatgctaaca acaaataatg aaatgtttac
     9361 tgaaaaacta tatgaagcaa gcatcttttc ttactctttg aacacgtatg ttgttgtaaa
     9421 tttaactacc gaagaagtga ccagaaaagt ctttgatata attactactc agcggataga
     9481 ggttaaaaag atacagcaag taaacagcga tattgaagca caaatattaa aaaaaatgaa
     9541 atgagataaa aatgataact agtattagat tggaactata taaatttaaa aagcaaaaac
     9601 atgtgaatgt tgttctatgt gggactatag tgttttattt tttaatggta gcattaacta
     9661 tttttaaacc gggttatttt gaaaaaaaat taatggttga aaattccttc tcaacattac
     9721 agtttcttcc actaataata atgatatttg catcagagtt gatgtccgca gagttccggc
     9781 taggaacaat taaaaattta attgttacat caaaatcccg cttgcaaatc atagcatcaa
     9841 aatttatttt tcttttaatt attatactat cgctattttt aggaattctt ttgcttgata
     9901 ttttcattag cttttttatc tttcaagaaa gcatccaatc tacaataatg aaatatacac
     9961 ttctttgggt ttttggaaca gctattgaaa cacttttact aggatctttg gtcttctttt
    10021 tatcgataat ttttaagaat cctgcaatac cagttactat tggcgtattg gtctatctgc
    10081 tggtgggatt ggtggatgga atgaattttc acttgatttc taagcttaaa tttttgcgat
    10141 ggaatgttct taatttacta aattttaaag cgcagttaat tgaccattca ttgcagaatt
    10201 atactaaatt aagtcttacc gatttctcta ttggaataag cttgtatata atcttttttc
    10261 taatgacaag ttatgttgtc tttcgggaca aaactatttg agaggtgctt taatcatgaa
    10321 acacggattt tctttattga atgttttttt attgattatg ttcattgtgc tttctactat
    10381 aatttggcta cgaaggacag atggttcagg tgccattcaa acaacaaact tacgttgggt
    10441 gaactttatc atattattgg ttttttttat ggttttagta gtaattgagt taatagttta
    10501 tattatttca ctcaaaacca gaaagtagat taatttttaa tggttatagt acgaaaatcc
    10561 ttagctgtca aattgagtca gtatttcttt tatcggttat ctgtaatctg attaatgaat
    10621 accattggtg atgtctgcca gattacaagt ttaacccgaa taatctgtca attatttagc
    10681 aagatttgat gcagtgtgtg ccaacttgaa ccttgaaaca gtaattaatt cctagtaatg
    10741 ttcttctgag ttctttagca ctcaagtgct aaagatgcat ttttaaattc ttacgttaca
    10801 gacaattagt gttcttattc aattttgact tgaatataag caattttagc agtgattaag
    10861 tgaattgttt tatgaccata atgttgctta tgaatgcaag catgggtcat ctgtaatcag
    10921 cctttctttt gattttgata gtcaaaggct atcaaaattt ccttatttat aacttaattt
    10981 cacaaactga aacaaaaaat tattgtgtgt aaaaaagcag gtcacaactt aacactttgc
    11041 ccaaggttca tcattaaagt aatagagaca ttgacctcat ctatgctcaa aatccgcaag
    11101 cgacccaagt cgcaggcttt aaacaatggt agactgattt taaccgcacc gttaataaag
    11161 gtgctaaggc cattcgaatt gtagtcccaa ttattaagaa attaacaacc cctgatcaaa
    11221 agcaacttga tatcaccgac gaacgcgcca ttgtcggtta ggttatcgtt atctgcccat
    11281 cttcgacgtg gcacaaaata gtggtgaccc agtcctaagt gctaaagatt ttgtcaaaga
    11341 aaacttggcc gatcatcaga atgtgacgag cttgtataac gcgttcaaag attatttaaa
    11401 ccaacaaccc gatcttcaag tcagcaaagc gtctttagtg gcattaaacg gggctaaggg
    11461 atactttcaa cctaataaaa tcgtcattgg tggtgattta aagacgttgt atcacgaaca
    11521 tgcgcatagt cagctacatg gtttaaaagc agcttttaag gatcgcccac gagcctatca
    11581 ggaaacccaa gccgaagcgg tcgcatatgt tgccatgaaa aatattggcg ttgataccag
    11641 taactattca cttggttata tggccacgtg ggctaaagat aaaggtgtga tccatagtgc
    11701 tttgagtgag atccagcaag tgagcaacaa agtgattgag cttagtgaca ggttaaccaa
    11761 acaattaggc ctacaagaag caccaaaaga gcctgagcat gatctaaaaa agcaatcaga
    11821 ccaggcactt aataagtcgt atcaaggctt acaacaacaa attaagcaag caactagtcc
    11881 acaacaaaaa gtgcaattta aaaatcggtt aaatgatgta cgccaggaaa gcagtaagtt
    11941 aactcaaaaa caactgcaag catttgctga acagaatccg gaaatcaaac aacctgatcc
    12001 tgaatctgat cgaagcatga aacgttagcc agtttttaag ggacatgcta taatggaaac
    12061 agaaaaagga agccccgccg aaaacagaac ttcccatgca agccgcttca aaggcggtgg
    12121 cattagttaa gaaatgatag ttgagtcacc ctgtaaccta gccaaagtta cgcagggcgg
    12181 ctttttattt gtggtgcttg tcgatatagc tgagtagcgc gattaaaaac gtgccaaaca
    12241 gcaacatcaa cgagagtgtc tggaagatgc tcattgactg tgaaaccttc ctgaagatta
    12301 ttccatgttc ccatgggcct cacctcgcaa gggaaaagac agccaccgcc cttaaaactt
    12361 tagagtccta atatacttga ctttacgtag aaaacttcct gcgtaatcta ttatacaggt
    12421 gaattaagta ttgaccaagc acagcaagaa ttaagtcatg gagtttcata ggatcctaaa
    12481 tttgatcaaa ttaagaatca gcaaaacatc ttttgtagat accctttttt aagttcttgg
    12541 agtttttcaa gcttacgctg atgaagagtg atagtgtcat caaggctttt gaaaaatgct
    12601 cccaatttga cttgttcacc tttgttcggc aaagttactt cgatagattc aatatctgaa
    12661 ccgttatagc taggcaaagc accaacttgt gcatatcgag gtaagttgat tgtttcaaac
    12721 aaagtctttc cgaaatcaat attccaagag ccataaaaga catacgccat ggtgttgtta
    12781 tcaattaaga atggacttgt cacaagacgt ttacgattga gcatgatcgc tgctccaact
    12841 ttcgcaaata tgactgctgg gaccgtctca attattttcc attttttgcg tgacaactgc
    12901 tcgtaattga cataattatt ggcgttaacc atttcatgct cgttaccagg cttattcata
    12961 tccgatacct tgtaaaatgg aacaccttct gttccacctt gttcagcatc tggaaaacca
    13021 attccagatt gtgttttacc aacttccccc aacttacgct gttcccaagc gtcagcaaac
    13081 cctgcaaatc gcaattcagg aacttttgca ccatttttag gaaacagttt ctgcaaatag
    13141 ccctgtttaa gtttcttgag cttagctaac ttacgctgat gaaaggagat gaggtcgtct
    13201 actccatcta aaacagacac tattgtttcc tgttctgctg gacttggaaa tttaattttc
    13261 atatcagcaa tcatttccat tcgaacacta tcaactgatg tttttgctgt cattgacatt
    13321 acacgacgat aaaaattctt tgaaaaatag tgataaaaat atttcgccga tactccatga
    13381 ttaaagttaa acatcctata tacacgttga tgcaagttat acttaccatt tacataatga
    13441 aaaacttttc ctgtaccaac accatctcca actgtcaaaa cagcttcttg gtcataaaga
    13501 tattcattac ttcgttcaat tgtcgcagaa cgaacataaa atggatattt accatcttca
    13561 actttatctt gagtattacc tttgccagta gaaatatcac ataattcttt tgtcttacgc
    13621 tgttcccaag gatcagtgaa accattaaat cttaattgcg gatatttagc ttggttatct
    13681 ttcattgtga gcctccggtt ttgactgatc attaacctgg gtggtcacta actggctagc
    13741 taattcatta aaggcttgtt cattctgact gatttcctcg tctagttgct tcagatcagc
    13801 tttaacttgg tccagatcaa tctcgggttc cggttcaaac g
//
