LOCUS       gnlProkkaJKLCBNIB_40   14529 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JKLCBNIB_40.
ACCESSION   gnlProkkaJKLCBNIB_40
VERSION     gnlProkkaJKLCBNIB_40
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 16:27:56
            Original ID  :: gnl|Prokka|JKLCBNIB_40
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14529
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..312
                     /locus_tag="ctg40_1"
                     /transl_table=11
                     /translation="MKSSPQIKELLSVCQNFRDMINGNTYDKDIRKWIEKAKATRNMAL
                     TNFAYGIEKDWEAVQAAIDIPFSNGLLEGTVNKIKAVKRQMYNRAGIKLLRAKIIYSQ"
     protocluster    1..14529
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4178:4529]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4179..4529
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14529
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14529
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             1188..2699
                     /locus_tag="ctg40_2"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             2772..3839
                     /locus_tag="ctg40_3"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVSKKVAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVCLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             3876..4160
                     /locus_tag="ctg40_4"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(4179..4529)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_5"
                     /sec_met_domain="PqqD_RRE (E-value: 5.6e-11, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(4627..6015)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 89.8; E-value: 2.3e-27)"
                     /gene_kind="transport"
                     /locus_tag="ctg40_6"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIISEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(6266..6661)
                     /locus_tag="ctg40_7"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPAAETPAPAAE"
     CDS             complement(6668..7441)
                     /locus_tag="ctg40_8"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDGFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(7447..7974)
                     /locus_tag="ctg40_9"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(7961..9193)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.5; E-value:
                     1.8e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg40_10"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQMGTVVTTPVVTAHQPSVPAIIH
                     TMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNISERT
                     LYRKIKEYELD"
     CDS             complement(9203..10297)
                     /locus_tag="ctg40_11"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(10302..11342)
                     /locus_tag="ctg40_12"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             complement(11361..12395)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_13"
                     /sec_met_domain="PF04055 (E-value: 1.1e-17, bitscore: 57.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
ORIGIN
        1 tataagtcct caccgcagat taaagaactt ttaagcgtgt gtcagaattt cagagatatg
       61 attaatggga acacttatga taaggatatt agaaagtgga ttgaaaaagc gaaggcaaca
      121 cggaatatgg cactgacgaa ctttgcatat ggtattgaaa aagactggga ggcagtacag
      181 gcagctattg atatcccctt cagtaacgga ttactggagg ggacagtgaa taaaattaaa
      241 gcggtaaaaa gacagatgta caatagggca ggaattaaac tactgagagc gaagattatt
      301 tattcacaat agaagaagta ccaccaaatt tgacgaagaa ccagaaaaag atttttcatt
      361 tctcatattc tcataaataa gaaacaagtg gcagtaaact aataagatag actatgagaa
      421 atgatttaaa aacaggcatt tctcatagtt tcttcgcaaa ataacccgga ttttgcttca
      481 tttctcatag tgtagtgtgc cggaagctga cattgaataa ataaaactat gtattccttt
      541 tgcttgcttc catacacagt gtcttagttc cacatattgt gggaaaagat tccctaaggc
      601 ttgggaaagt attcccgtat tttgtgggaa agtattcccg tatattgaag gaaaactttc
      661 ccacaatata tgggacaatc gagaccaatg agcatcttca agcaaaaagc cactatttta
      721 tctaaatagt agcttcattt cctgataaaa ataaggcagg ctgaaagaaa aaaggaagaa
      781 caaatggctt ttgactatga gaaataccct gaaatactat gagaataagg tggcttttga
      841 gccaaaatat gggagaactt atgagaaata ccgtttcgaa aaagtgtttc tcataagata
      901 tctatttgat tagctttcgt ttatcgaaaa acaatgagaa tatgagaaat gaaatgaaga
      961 aatctttttc aggagaaata aaagtaagtt cataatggtg ctgcattgaa ttattttttg
     1021 gcggagttat tctaacactt aatagttcaa aagcagatat ttctctgacc caaagataga
     1081 actaatgatg aattaaaagt tgcaattatg gttttcttcc cacaacaaac gggaaaagtc
     1141 agaagaatca tgtacatttg taatccgaaa actaaaagaa catcgcaatg aaaatatttc
     1201 caagcagcag tatcaagaaa ttggacgctt ataccattga gaacgaacct attgcatcaa
     1261 tcgatctgat ggaacgtgca gcaaccgtat taacaaaagc catcacagac agatggaata
     1321 cagaaacgcc ggtcactatc tttgccggac cggggaataa tggcggagac gctctcgccg
     1381 tagcccgcat gatggctgaa aaaggatata aaatcgaggt atttctcttc aacacgaaag
     1441 gagaactttc acccgactgc cagaccaata aagaactggt agaaatgatg gaagaagtaa
     1501 aattccacga gatcagtacc caattcgtac ctcccgccct gacgcccgac catctggtaa
     1561 tcgacggatt attcggttca ggcctgaaca aaccgttgag cggcggattc gctgccgtag
     1621 tgaaatacat caattcctcc cctgccatgg tagtagccat cgacattcct tccggactga
     1681 tgggagaaga aaacacattc aacgtaaaag ctaatattat ccgtgccgac gtaactttca
     1741 gtcttcaact gccgaagctc gcctttcttt tcgcagagaa cacggaattt gtcggagaat
     1801 gggaagtgct ggatatccaa ttgagcgaag acggtattga agaaatggag actaactacg
     1861 aaatgttgga aatagagcaa atccgttcac tcatcaagcc acgcaaacag tttgcccaca
     1921 aggggaactt cggccatgca ctattgattg ccggttcaaa aggaatggca ggagcctctg
     1981 ttctcgctgc ccgcgcctgc ctccgttcgg gagtaggatt actgactgtt catgcaccaa
     2041 tgtgcaacaa cgacatcttg caaacctcca tacccgaagc aatcgtagaa accgacatca
     2101 acgaaacctg ttttgccgta cctaccgaca cggacgacta tcaagcagtc ggcatcggtc
     2161 cgggactggg acgaaacgag gaaacggaag ctgccttgtt ggaacaactg gaacactgcc
     2221 agactcctgt tgtggtagat gccgacgcac ttaatatcct tgccaaccac cgccatgccc
     2281 ttacccacct gccgaagggt tccatcctca ccccgcatcc gaaagaactg gaacgtctga
     2341 ccggcaaatg ccaggactct tacgaacgtc tgatgaaggc ttgcgaactg gcccgtgccg
     2401 cccatgttca cattatttta aaaggagcct actccgccat tatcaccccc gaaggtaaat
     2461 gtttcttcaa cccaaccgga aatccgggaa tggcaaccgg aggtagcggt gacgtactga
     2521 ccggagtaat cctggcactg cttgcccaag gttaccccac cgaggaagcc gctaaaatcg
     2581 gcacttacat tcacggactg gcgggcgatg tcgctcaaaa gaagcaagga atgatcggaa
     2641 tgatcgcaag cgatattatc acctgtctgc cgacagcatg gcgacttgta agcgaataaa
     2701 agttaagaac ttaccctttt ttcaataact tcattaactt tgttttcaaa accagttaaa
     2761 aagaaccgaa tatgaaaaag ttgattatag cagcaggact acttatgaca acgtccgcct
     2821 atgcacaaac cgaagtactg acgggggtta cccgaggaaa agactatgga gtggtttaca
     2881 gtcttcccaa aacccaaata gaacttgaaa taaaagccaa caaagtcaac tatactcccg
     2941 gagaattcag caaatatgct gatcgttacc tacgactgac caacgtctcc gccgaccctg
     3001 aagagtactg ggaactggct agcgtaaaag tgaaatccgt aggtgtgccc aacagcgaaa
     3061 ctacgtattt cgtaaaattg aaggataaga cagtagcacc gctcatggaa ctgacagagg
     3121 atggcattgt gaaaacgatc aatgttcctt acagcaacag cagtgtaagc aaaaaagttg
     3181 ctcccgctcc cgcagtcctc caaaagaaag cgaatcctcg cgaattcctg accgaagaga
     3241 ttctgatggc tagttctacc gccaagatgg ccgagctggt ggctaaagag atctataaca
     3301 tccgcgaaag caaaaatgcc ttattgcgcg gacaagctga taatatgcct tcagatgggg
     3361 cacagcttaa aattatgctc gacaatctga atgcacagga agaagccatg acacaaatgt
     3421 tctccggcac ctgcaacaaa gaagagagaa cattcactgt ctgccttacc cctgacaagg
     3481 aattcaacaa tgaagttgcc ttccgcttct cgaagaagtt aggtgtagtt gccaacaatg
     3541 atttggcagg aactccgttt tatatcagtc tgaaagacct gaaatcggtc aagatgccac
     3601 aggaagacgg taagaagaag aaagatttag atggaatcgc ctacaacgta cccggacaag
     3661 ctatggttac actgaccgac ggtaaaaaga aactttacga aggtgagctt cctattactc
     3721 aatttggtgt gatagaatat ctagctccgg ttttgttcaa caagaattct accatcaaag
     3781 tttattttga tccgaatacg ggaggattgc tcaaagtgga cagagaagaa gggaaataga
     3841 aaaacgagga agtaaacttc taaaaaacaa agaatatggt tggtgaagga catgcattcg
     3901 acatgatacg ccgaataaaa gagggacggg aagcttcccg cctacgtcgt gaacgtgcta
     3961 acgataagtt gaagcatcta aaccgtgcaa acgaacctta tccactaccc aacaccaccc
     4021 ccgaagaaat ggaacgtatc atccacgact cggagaaaaa gaaagagaaa gacagcaatt
     4081 attttgtttg gggaacgctt attatcatgg gagtcctgat agcaattgcc gtcatacttt
     4141 gggctgtatt tatcaaataa ataataataa gttcctattt atacgactgg tatcaccagt
     4201 tttataaatc catctttctg catttgagaa agataagccg atacacgcga ctcgtagccc
     4261 tcttcatttt gaaagtggtc tgcgagtttt tctataatct cacgaacatt gcgttttcca
     4321 tctatcagtt cccatacagc cgtaccgtgt tcttccaatt tcacatgaag ttctttcgac
     4381 attcctttcg gcacaaggaa gcgttgcatc cacggatatt taaaacgggg aaaggagagc
     4441 acaattgtct ccccttccct ttctgctgta atatgttcac tgcgacaggg aatgacctct
     4501 aacaggttga ttttctcttt ggcagccata cttcttattt tttatttcag agtattcata
     4561 ctgatactct tctgtttaca ccttgataca aaattccttt gtcactttag gtattgaatt
     4621 tcctagttac ttttggatat tcgcctcttc caaaccgtat cccttcttct tgttctctgc
     4681 cttcaacatc aaagccacaa tcagagcaag cacaccaaaa agagcaaaaa tagtcatcgg
     4741 caacgtgtag tcataagtct gtgcaccgtc tactaccgga cctttgcaat aagtattcaa
     4801 cacccatccg atcaacaaag gaacccccat caatccccag ttctgtaccc agaaaatcaa
     4861 tgcgtatgct gtacccaact gtttttccga aataatcttc ggaacagacg gccacatagc
     4921 tgaaggcact aacgagaagg caaatcccaa tataatcatg ataatagtag caaaccacca
     4981 tatattcagt ataggcagag caaacatcgt atgcacaaaa ataagcatca ctgatccgat
     5041 tatcattaac gtggctccct taccgatacg gtcataaagc gagccgaaca acggagtcag
     5101 gataatcgca ccaatcggca acaatccggg aatcgttccc gccaacttcg gatctacatt
     5161 atacttctgc accatcaagt cggcagcata cttgataaag gggaatacag ccgagtagaa
     5221 caatacacat agtaatgcaa tcagccagaa tcctttattg gtaatgatat acacaatatc
     5281 tttcatacgg aacggctctt ccggttccaa tccctctgca tccaaagaag catccaactt
     5341 cttatcatag aaagtataaa ggaagaaagc aatcgtaccc acgcacaaca taatcagaca
     5401 aaacagaatc ggagcaggaa tattggtatg gaatgtgcca ctctcatccg tagatccgaa
     5461 aaagtcggcc aaaggaaccg taagcaccat tgccagagtt gttccgatac gtgccgtagc
     5521 catttcaagc cccatagcca atgccatctc cttacccttg aaccatttca cgataatttt
     5581 ggaaactgtg ataccggcaa tttccacacc tacaccgaag atagcatacc ccaatgcagc
     5641 cagggttacc tgtgttttga atccgaagag catggcacct tccggaaaag tagtagaaat
     5701 cgcatagtat ttcaatccac aaccaaacac catcaataag caagccccca ttccggtgaa
     5761 acgaactccc atcttatcca aaatgatacc accgaaaatc agcatcaata ggaatacatt
     5821 aaaccacccg taagcgcttg tgaagaaacc ataatcaaga ctgtcccata gtagttcttt
     5881 ctcaagcatg ggttttagag gagacattac gtcggtgagg aaatagccgc atagcatagt
     5941 aaatgcgact aatgctagaa cactccatcg gagtacggcg gagtcattca atttctgttt
     6001 caaatgttct gtcattgtta tatttaaaaa tagtagttaa taatcttcat acgaccaaca
     6061 aaggtagtta aatctcgttt gtttctatca aaaagagatt gtttttacaa gaaaaagtta
     6121 agtgcggatt acactgacca cacggaagat tgaaaatccg tgtaatctgc gtaatccgca
     6181 cttaaatatc aaagaaatgc agcatccgtc tgcaccttcc cattaatggt tttaccccca
     6241 aagtcttacc tgacgacaga gtgaattact ctgctgcagg agcaggagtt tcagcagccg
     6301 gtgccggagt ttctgtagca ggtgcattgg tagcaggagc ttcagtttgc ggcgcagccg
     6361 tacctgcggg taagttatac gggttagtct gttgttcttt ctgtgcctgt tccaacactg
     6421 cgtctttagc aacagcagag cgaggaacta cataagcagt agcaatgctc attaccacca
     6481 tgaagatagc taagccccat gttgcttttt ccagaaaatc tgtagtcttg cgcacgccca
     6541 tgatggcgtt agatgaagag aaaccagaag caagtccgcc tccttttgag ttctgaatca
     6601 gcacgatgaa acacatcaac aaggctgcaa taaccattaa gataacgaat aataagtaca
     6661 tttttagtta ttttgaatta gcgttaataa tcaatttctc caaaaatctg atttggtctg
     6721 caaagtaagc attttttttt ggatatttca agcttaattt tttaattatt tcaagagctt
     6781 ttgaatatcg ttgctgttta acatagattt ttgccaaagt ttccgtaaaa cagctgtcat
     6841 cttcctcttc ttccttcatc gtttcttctt cggtaagttc gtccgaagag gttggcgaag
     6901 atggcatttc ttctcttaaa ggtttcttgc agaggggaga gtcgctctcg ctcttttcta
     6961 taaagccgtc aatcagttcg tagcctttga gtttgggcgt ttcttcggcc gactgttccg
     7021 tggccggagt ctcctccaaa agataagagg tgtaatccat cgaatagtcg aagctggtgc
     7081 gggcagtcac ctcttcgggt actgtggaca agaaagcgtc aatcaatgct aatgtgcggt
     7141 ctacggacgg ttcgtctttc aacacctccg tgagaggtac tccctttttc cgtgcctgca
     7201 catcatagcg gtcaccttca atcaaccgga acaactgccg tctgtctgca atgtaaagaa
     7261 ctgctttccg cagttctcca ccgaaactaa tatcatggag aatatacaga ttcttcagat
     7321 acagcagacg aagtgactga aaatacggat acctcgcaag aagattgcgc agttcgtaca
     7381 aagtatccct attcagcgtc tcgggatgct gaatccattg ttgaaagtta acagaagtca
     7441 tttatattac cagtttgcta cagttgcatt aaaaatttgg tcggtgatct ctttagacat
     7501 ttcagcaatc aatccgtcct gtacggcagt cagcaactgg ctagagtcgt aggtacggaa
     7561 cgcagaaaac tgttgttcaa agtcttcggc atgattggta ttgttgacaa aacgcacatt
     7621 gacggtgata gtcaacttcg tctccgaaga ataaccgtcg gcagatactg cctggttgta
     7681 ctgattgtat cctgtgattt ctccgtcaat ctgcaagtcc gcattctgat tcggcttgag
     7741 cagttgcaga cgggtctgcc ggatgaagat atctttcagg tcctcattga atttggttgc
     7801 caacggagca tatacatact ccgacttgat cggaaagtcg gctatcgaaa tggtctttac
     7861 cttatcgtaa ttgatagacg atccgttaaa cttataggaa acagtgcacg caatgactac
     7921 caacggcaag ccgaacagta acaaagggcg tattattttc ttaatccaat tcatattctt
     7981 ttatttttct ataaagtgta cgctcggaaa tattcaagtc cttggccgca ctcttccgct
     8041 ttccatgatg cctctcaagt gccttgcgta tcatttcttt ctccacttcg tccagtgaca
     8101 aaggagattc ttctacatat tcttccgtgt cttgtatgtc atcatcatcc ttgcaaaccg
     8161 tgggctgcat ggtgtgaatg atagcaggta ccgaaggttg atgcgccgtc actaccggag
     8221 tagtaaccac cgttcccatt tgtcctacct gcccggcacg ttccgccatc agattgtgca
     8281 ccatcttctt cagctccgcc acttcctggc gcatatcgaa cagaacagaa taaagaatct
     8341 cccgttcgct ctcaaagcct ttactctcac gcgttcccat cagcgcggga agacgttgcg
     8401 tattttgtgc gggaagataa ttctgcaaga tagcagcaga gatctccctg ttggtttcaa
     8461 tgatagatat ttgctcggtg atgttcttca actggcgcac gtttccgggc cacgggtaag
     8521 ccaacaactc tttcttcgca tcctccgtca actgaatagc aggcatccgg tatttctctg
     8581 caaagtctgc ggaaaactta cggaacaaca aaagtacatc gtcaccacgt tcacgcaaag
     8641 gcggtatttg gataggcacc gtattcaacc ggtaatatag atcttcacgg aaacgtcctt
     8701 ctgcaatcgc ttgtgtaaga ttgacgttgg tagctgccac cacacgcaca tccgtttttt
     8761 gtactttgga cgaacctact ttcataaact cgccactctc cagtacacgg agcaaacgtg
     8821 cctgggtaga catcggcaac tcccctactt catcaagaaa aatagtaccg ccatcggctt
     8881 cgccaaagta ccctttccgt tcgccaatcg caccggtaaa cgcacctttc tcatgtccga
     8941 acagttcgga atcaatcgta ccctccggaa tagcaccaca gttgacagca atatactgtc
     9001 cgtgcttcct ccggctatat tgatgaataa tctgcggaaa actttctttt ccgactccac
     9061 tttctccggt aatcagcaca gacaaatcgg taggagctac ctgaatggca acatctatgg
     9121 cgcgcgacaa tgcttcagta tttccaataa taccgaaacg ctgtttcact tgttgtatct
     9181 ctgctctcgt catcactcgt ttttaatctt cgtctactgt atccagcttc agtttatcac
     9241 tatcgtcacg tttctcgtaa tactgtttac gcaacggatt ggcacgagcc actttttccc
     9301 gctgacgatt acggaacacg tcgatggcaa catagattgc ctgacggaaa gaatcttcac
     9361 aagccactcc cttacctgca atatcgtatg ccgttccatg agccggagaa gtacgtacta
     9421 ccggcagtcc tgccgtatag ttcaccccgt cttccatagc caaggcctta aacggagcca
     9481 gcccttgatc gtgatacatc gccaggatac cgtcaaaatg agtataattg cccgaaccca
     9541 taaagccatc ggccgcataa ggaccgtagc aaaggattcc tttttcttcc atttctttca
     9601 tggcagggat aatcacttcc tgctcttcca ttcccaacaa accaccgtct ccggcatgag
     9661 gattgagaga gagcaccgca atacgcggag cgccgatacc gaaatcctgt ttcagacaac
     9721 gatggaatat catcagtttc tcctgaatca gttctttggt aatcgtagtc gcgatctctc
     9781 tgacagggat atgtgtcgtc accaaagcca cccggaaatc attcttcatc aaaatcatca
     9841 atgacttatc accattgccc agacgttctt cgatatattc cgtatgtccg gggaaagaga
     9901 actcttccga ctgaatcgta tgtttgttga tcggagctgt tacgataacg tctatcaacc
     9961 cttcgcgata ttcttcgatg gcacgttcca aagcccccaa cgcagcttta ccggcttcgg
    10021 gatcgggttt ggaaaattcc actttcacct catcatccgt acagttcacc acgctcaaac
    10081 ggttgtaccc cgcttcggta gcagagttga caatgctgaa attggtctgt atatccagcg
    10141 ctttgcgatg ataagccgct actttcggtg agccataaat gatcggagta catagttcca
    10201 acatcgtagg gtcggaaaat gtcttaagaa tcacctcata gcccaccccg ttaatatctc
    10261 cttgggtgat acctatcctt atcttgttat cttccatgtt tttatttatt agtttgttcc
    10321 gcttccttag atgcctctcc caatggaatc tgcttctgct gaacttcatt cggaagtttc
    10381 agtgtataca gagatgcttc catctggcgt accaggttgc gtttcatttt atcaggtgaa
    10441 taaacaaata tttctgctgt aataattcgt tggtttttct cgtccagacg agtatgagat
    10501 acatacggac cacccataaa gtcgcccttc atacgccaca ggccacgtgc ttccattgtg
    10561 tagctgttct gtacattgat cggacggaca tcggtcagta aactatcggt cgacatataa
    10621 acgccttcct tgaatccggg gatattggct ttcatcacgg agtcacgttt gtgcacaaaa
    10681 tattctttgg taaacgtatc cttgtcagtg tacggataag agtacatcac aaagttacgg
    10741 tcggcagtac ctgtgttggt agaagcccag aagaaatcat ccccggtctt tgaattagcc
    10801 agttcggcat ccacccagat gtcgcatccg aacaaactgt ccactttctg cgaaatgaaa
    10861 ttactgtgtt tcccttccag gaacgtaatc tgacggttca tttccgcacg ggtaaagaag
    10921 tcgacaatcg tctttttgtt ctcttccaca aacttctcaa actcttcttc gttcggagcc
    10981 tggatagtca atatcatctg cggattggca tacacgtcct tcgcatattt gaacgaggct
    11041 ttcgtatata tatcctgtat atctacaata ataatgttac gtatcaactt cagcgtagaa
    11101 tcataatctt tcggtgaagt atacataatc cggaaagaag gttccgactg cggcaaaccg
    11161 ggcatatcag catcgagcgc atcatgtaaa gcccttccgg cagcacgatc ccaaacaccg
    11221 tgatctacta caaccaaaag ctcgtaagca cgaccactag aggtgtgatt tcctttcaga
    11281 ccacaagatg caacaacaaa ggctaccaaa gcgatgcata aaataaaaga gtactttttc
    11341 atgatgttcg gttttatata ttaactttca ttatttttct cctgtttcgc tgtcgacagc
    11401 ataccgcaag cggcaaaaat atcttcgccc ctggatgaac ggatagtggt gaaaagtccg
    11461 tgtgacgtca gataatcacg aaaacgggtc atcgtatcca tgtccgcccc ctcgaggtct
    11521 acccccggta tggcatgaaa acgaatcaga ttcaccctgc aatccagccc gcgaagaagt
    11581 ttcagcaact ctttggcata gacctgcgaa tcattgagcc ctttaaaaac aatatattca
    11641 aacgaaagtc gacgttgttt actaaaatca tagtttttta acagttccac catttcggtg
    11701 attgaaaacg ccttttccgc cggcattaat tcagcacgct gaacggtcag cggagagtga
    11761 aggctgatgg caaggtggca gtcattttct tcgataaagc gctgcaatcc tttccgtagc
    11821 ccgacagtag aaagcgtgat acgcttcgga ctccatgcgt aaccgtaggt agcggtcagt
    11881 agttccaatg ccttcaatac ctcatccagg ttatcgagcg gctcgcccat tcccatcatt
    11941 acgacattag tcagtttgtc ccgttccggc agcgaatgaa tctggtttat gatctggctg
    12001 gcggtcaggt tagcggtata cccctgtttg ccggtcatac agaacttaca gttcatcttg
    12061 cagcccactt gtgacgacac gcacaacgtt gcccggtcat catccggtat ataaaccgac
    12121 tctacaaaat ggttctcacc cactttataa agatacttca ccgtaccatc tacagagcgc
    12181 atttcatcta ccggagcttc cgctcccacc tcatagttct gcttgagcaa ctcccggtgt
    12241 ttcaatgaca aattagtcat atcatcaatc gaggctacct tcttttcgta aagccaggat
    12301 gcaatctgct tggcagcaaa gccgggcata cccagtcttt ttgtcaatga ttgaagctct
    12361 acaagagtca ttcctaaaag gggatattta gacattcttc tttctgttga tagtttatat
    12421 ctgcaaatgt aaggaaataa agtcgatttc cgtatagcag gaatgtaaaa gttaacaaaa
    12481 aagggaagta tgcctccgtt atgattcaac cacgctgata tattgaagta gcttttgcgc
    12541 catttcagaa tcctcgccat tctttttcac ttcatgaccg tacgcctcac ggaaacaagc
    12601 cagcgcctct tcccgttcat tacaaaagct gtgcaaaacc cctaggttct gacaagccag
    12661 aatcgtatct tcatcctccc atcccagata tttctttcgc agttcaagct ctctgaagaa
    12721 agcctctttc gccattggat aattctccaa cttcacataa gcctgtgctt tgtaataata
    12781 taccagacag gaagcattag ggtcagtatc atcgtgaaaa tccaaagacg ttgcaatacg
    12841 aatcacgtta tcatagtctt tattcatgta atactgctgc ataatatcac atctcaatgc
    12901 ctcgtagcgg acagtcaatt ccgccagacg cggtttttcg ctgaaataca tttcatgcag
    12961 aagagactca cggaagaata aagtagacgc ctgctcatcg ccacgttcat tcatcatccg
    13021 tttgaattcc ctgcacagat aatacaactg tttatgacaa gcgacgatct gttttttgct
    13081 atctatctgt atagcaatgt ccaacgcctg attcatcagc atccatgctt catcgtatcg
    13141 tttgatataa taaagacatt taccctgcat acgcaaacat ttagccactc caccggacag
    13201 tctgccattc aatgactcgt gcatttcagc tactttccgg aatttctcgg cagcactctc
    13261 ttcctcatcc ttatagtaat cacaataagc cagatattcg gaaagttcaa tgacttctgc
    13321 ctgactcttc tcgtcagcag aagccgcatg ataatcaagc gccctattca aatagatcgc
    13381 cgcttcattg tattgctcat tgtagtaata tgccagagct agatttcggc aggtgttggc
    13441 aatctccagt tccggagtcg gtacaatgtt ttcctgcatc accaatgctt tcaagaaaca
    13501 gtcgcatgcc gtttcgtatt cttcattacg ggcataccgg catccctcat tcatcttcaa
    13561 taccgacttg gcaatgagtg gcatggcagc accttccata ctcttctcac tcacagcagc
    13621 tgccgccttc gtcagatgga aagaactgct caagaaagta gccatatcat tagcaatgac
    13681 aggaattaaa aaagaatcga tctcatcaaa gtccaattcg gcatagactt caggcgtaac
    13741 ttcaggattg tcgttcatga tcgccttcca gctatcttcc aacagagaac gattcgtgcg
    13801 atacagaatc tcgaaaatct ccacatcaca aatccaatcc ttcaatatat cccattcttg
    13861 catcttatag cattgatagg taatctccac tttataacga tacgaatcat ggtagcagaa
    13921 ctgtttcatg cgatagttat aatcggcaaa agtcaacgga tgggaaagga tttcttcctc
    13981 atccagcaga gcggaaataa tttcatggcg actatcatct atacattcgt catcttgagc
    14041 gaaatagcgt tcgattgcct ctaccatttg tgtgtcacca atgcaatatc gccctccttt
    14101 gttggtgagc cagctgctca tttccactct caactgcgac caaagtatct gattaatgtc
    14161 tgccatgctc ttcacttcat cttcggtaaa tccttctaaa gtaagtgaaa gcatcagaag
    14221 cgttcttcca atctcttcga aaccataatc agccgacaaa cgccgtaaca cactgtcata
    14281 gaattgccca acctcattga gccggcaata tccactcata tattcattga gagcatcgta
    14341 ctgaccgaac gaaaccagct cgttgagcaa tacacttaaa cagcgcggtt gtttagccag
    14401 cacccacgaa gcaagaatat cttcctgttg tgcagacaaa gccttggagt aagtagacaa
    14461 atattgcttt gagaacgact tggcatccgc ctgtgaaaag ccattcaact ggaaatgggc
    14521 gtagccatt
//
