LOCUS       c00004_gnlPro..        15161 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BFFPJGAF_4.
ACCESSION   c00004_gnlPro..
VERSION     c00004_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:13:26
            Original ID  :: gnl|Prokka|BFFPJGAF_4
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 67601
            Orig. end    :: 82762
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15161
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[77601:81091]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13490
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..15161
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15161
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             157..285
                     /locus_tag="ctg4_73"
                     /transl_table=11
                     /translation="MKNIAILAIAGAACLVASCSQQQQQQQTTAPAPAPVVQAKGK"
     CDS             complement(495..1085)
                     /locus_tag="ctg4_74"
                     /transl_table=11
                     /translation="MSGLANAFLALLPPDQAALPAAGAEARWLADTAVVQSAAIARDNR
                     TVLFGWLNNILVNSNLRDRGLCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCV
                     YVNAAGKGLQGSIVLDAWKNCGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGME
                     HHLVWPGWARKRPMLVQRIFQSDQQNEAKAAAE"
     CDS             1325..2935
                     /locus_tag="ctg4_75"
                     /transl_table=11
                     /translation="MLTIKNLTKSHAGRTLFRETEMTINWGERVALVGPNGAGKSTLFR
                     MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITPEMEQAIHTIRTAEN
                     ANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRPAREMSGGWIMRAYL
                     AKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHDRDFMDELVESVYDI
                     DNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFIDRFRSINSKAGQVQS
                     RIKQLEKMKIIQKPVACRKVFKFNFPQPPRSTQKVIELEKVCQSYGDRRVYENLDLLVE
                     RGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFSQARTENLNPENTVL
                     EEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLSLVKFLVDPPNLLLM
                     DEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLHVNRGTITAYAGGYD
                     YYLEKSGILDDEKGGITAE"
     CDS             2998..3516
                     /locus_tag="ctg4_76"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LMEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLAEPDEDGAPPGA
                     LRENEEAGQ"
     CDS             3643..4389
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_77"
                     /sec_met_domain="adh_short_C2 (E-value: 3.3e-75, bitscore:
                     245.1, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILISRSPSSCGG
                     AAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGITRDSLMLRMK
                     EEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQANYAASKAGL
                     IGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKEQGSVEDIAA
                     LTAFLASDDARYITGQVIACDGGMTM"
     CDS             4413..5618
                     /locus_tag="ctg4_78"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSVLLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPAA
                     GASLRMVAIPGGTFLMGSTAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPGAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDVMTMHRLWNFSKG
                     EP"
     CDS             5632..5805
                     /locus_tag="ctg4_79"
                     /transl_table=11
                     /translation="MIIALRTEHVTREALWNYFVPGCNEHYLLHIMRVSPSFIPELDTV
                     AVHGSRIVGKHR"
     CDS             5917..6051
                     /locus_tag="ctg4_80"
                     /transl_table=11
                     /translation="MYAAALQVCELQRGSLSGLKGRYVKATVYHMDEKRAAEFDGIFR"
     CDS             complement(6269..7009)
                     /locus_tag="ctg4_81"
                     /transl_table=11
                     /translation="MKKTLTFLIAMGSFAVSSEAATVFNYYTPGTDNYNSTIHGFYLGL
                     GSSSLAPSDSSSPSSLSGEIRLDSFTLRGAANGLGANVTYGFLVLNGSDNSVIGWSTNT
                     GTTAAGINLTFSFSSLDGSPLLLDAALTYRFLAVSQSVMDLMQDTSKTYLYAAGGTAAP
                     TANTEGDTVTISGGLTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEM
                     VPEPATVSLGLLGLAALMMRRRRA"
     CDS             7304..8011
                     /locus_tag="ctg4_82"
                     /transl_table=11
                     /translation="MNKLLSTLILSAGMSLSATAATSLLDSSIVGYSDFASQTADFGTL
                     KDSVSITSDDSNLTLSGITFNGYGANNRDVMSVTMVLDLTKINTPDAYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYNGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQIDQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             8443..8676
                     /locus_tag="ctg4_83"
                     /transl_table=11
                     /translation="MNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPD
                     EFLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(8710..9495)
                     /locus_tag="ctg4_84"
                     /transl_table=11
                     /translation="MVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSADGFRDYFVQLT
                     ECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLGIGEIGLNRNT
                     SHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLDPCRVLVDHCE
                     EHTFPLVKEAGYWAGLTLYPTSKLNPKRAGDILELYGMDRVWANSAADWGDSDPLALTA
                     LACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(9528..9800)
                     /locus_tag="ctg4_85"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             10001..10702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_86"
                     /sec_met_domain="SucD_FumR (E-value: 3.7e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             10724..12682
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_87"
                     /sec_met_domain="FAD_binding_2 (E-value: 6e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.7e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             12723..13490
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.5; E-value: 8.6)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_88"
                     /sec_met_domain="Fer2_3 (E-value: 3.2e-23, bitscore: 74.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 1.1e-10, bitscore: 34.5,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 6.1e-06, bitscore: 19.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTLNLTLKVWRQENREAKGRIETYAAKDIPVDASFLEMLDIVN
                     EGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPERQVTTCQLHMRKFKDGDTVWIE
                     PFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAPNANNIAVEKVKADAAFDAAAC
                     IGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSKRVLAMMKQMEAEGFGNCTNQY
                     ECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             14048..15160
                     /locus_tag="ctg4_89"
                     /transl_table=11
                     /translation="MNPPHRSSSAHRSAVPAYRKWYFGSGASQSGSTRRVRLSGQPDPD
                     PLPFEAIRIHEERKVGPPSTSADGHSAHGTFTIPEGAEGKKLYGTCSLFLGVDDWGILE
                     VKDSGGNVVAQVDLKENPQTAGEQGGHKYHTGTGGAQLPSGTYSWEVSQTNIDYNPASG
                     NTSICNYSIDVVPTEPGGRKEPEPCPCEGDTCDNSGGTPPSPPQARSCPEAGMESGALG
                     NYSSAGCSVTAESTATLMYWSCNFGAFRGLGGLPAGRVELRAEQNVSGLESPSSLAYNH
                     PLNSRLDVPEGGIAPGVRFNLVQGDRVIAMRCYTDGSVLPIGVDTSGGGRAALATVEGQ
                     SCLRWVVEDGSQYLFSAETGTLLSYTTTDRQ"
ORIGIN
        1 cttcagaaac cgggggtcct gctcttttct gtaatgccgt gacatggaac aagaaaatct
       61 cttgatttct acttgccacc atttacattg gtgccagcaa acctccgtgg atgcggaggt
      121 tccagtagtt aacaaacact gtatttaatt cgaattatga agaacatcgc tatcctcgcc
      181 atcgccggcg ccgcttgcct ggtcgcttct tgctcccagc agcagcagca acagcaaacc
      241 accgctcctg ctcccgctcc ggttgtgcag gccaagggca agtaagtttg cagcggggtt
      301 ttgccctgca acactagcaa attatccaat taatccgcac tcggtgtacg cactgagtgc
      361 gtttttattt gccctgagtc cggattccct ccgccatttg ccgattcgcc gggattttcc
      421 ttaaaaacgg cggataccgc aaaccgccgc ggtgcagcac cgtgtgccga ttcctgccgg
      481 atcaggcttc ccctttattc agcggccgcc ttcgcctcat tctgctgatc ggactggaat
      541 atccgctgaa ccagcatggg gcgtttcctg gcccacccgg gccagaccag gtgatgttcc
      601 atgccgtagg aatggccctc cggaaaggcc ttggaaacaa atggttcccg ccagtcctcc
      661 tcccatttgc cgccttcccg gtccttctgg gtcagcgtca ccagatgccc gcagttcttc
      721 caggcatcca gaacaatgga gccctgcaat cccttccccg cggcattgac atacacgcaa
      781 ctgtgctccc tgcccgttcc acggtctcga atcgtcagcc ctatgcggaa atacttcacg
      841 gggcggcggc gcaggtcccg gtacaaatcc tgctggacct gccagcacag ccccctgtcg
      901 cgcaggttgg aattgaccag aatattgttc agccagccaa acagcacagt cctgttgtcc
      961 cgggcaatcg cggcggactg gaccacggcc gtgtccgcca gccacctggc ctccgctccg
     1021 gcagcgggaa gagcggcctg atccggcggc agcagcgcca ggaaggcatt agccagcccg
     1081 gacatttgct gctgcacgta aggtttttgt atataatcct ccgccggagg agtacagcag
     1141 gaactccatc cgcacaaaag ggcggcagca agcaaaagcc tgaatgtctg cgtggtcggc
     1201 atggcgcgcc aaggctagca gactacgcgt aaaaatccag taaagctttc aaaaatgcct
     1261 gcctccgccc tgacggctct tgccttcccc tttccatccc ggtagaatac atcctctctt
     1321 caccatgctg acgatcaaaa atctcacaaa atcccacgcc ggacggacct tgttcaggga
     1381 aacggaaatg accattaact ggggggaacg ggtggctctg gttggcccca acggagcagg
     1441 caaatccacc ctgttccgca tgattctggg agaagacacg ccggacgaag gctccatcag
     1501 catggatgaa tacgccatcg tgggctatct tccccaggaa gccagcgaac cgaaggatga
     1561 aaccgtcctg gaaatcgccc tgggcatcac gccggaaatg gaacaggcca tccacaccat
     1621 ccggacggcg gaaaacgcca acaaaacgga tacgccggaa tacgcggaag ccattgacac
     1681 cttcaacgcc gccaacggtt accagctgga gcccaaagcc aagaaaattc tcaaagggct
     1741 ggcctttcgg gaaagcgact tccaccgccc cgcccgggaa atgtccggcg gctggattat
     1801 gcgcgcgtac ctggccaagc tccttgtcct ggagccggac ctcctgatgc tggacgaacc
     1861 tactaaccac ctggacctcc tgtccctgct gtggctccag cgatacctga aaaactaccc
     1921 cggagccatc ctgatgattt cccacgaccg ggatttcatg gatgagctgg tggaaagcgt
     1981 gtacgacatc gacaacgaag aactggtgga ataccgcggc aattactcgg acttcctcca
     2041 acaaaaggac gtgcgcttcg agcagcttca ggcggcctac cgcaaccagc agaaggaaat
     2101 agcgcacatt caggaattta ttgaccgttt ccgctccatc aattccaaag ccgggcaagt
     2161 ccagagccgc atcaagcagc tggaaaagat gaaaatcatt caaaaaccgg tagcctgcag
     2221 gaaagtattt aaattcaact tcccccagcc tccgcgcagc acccagaaag tcattgagct
     2281 ggaaaaagtc tgccaatcct atggcgaccg cagggtttat gaaaatttgg acctgctggt
     2341 ggaacgcggg gagcgcactg ttcttgtagg cccgaacggc gcgggcaaat ccactcttct
     2401 caaaatcctg gcgggcatca tccccattga ctccggacaa cgcactcccg gtaccacgac
     2461 gcgcatcggc tacttctccc aggcgcgaac ggaaaacctg aacccggaaa ataccgtgct
     2521 ggaggaaatc atgaaatgca gcgctgaaat ccgggaggaa gaagcgcgtt ccatcctggg
     2581 ttccttcctg ttccggaggc tggatgtgga aaaacgcgtc agcgttcttt ccggcgggga
     2641 aaaatcgcgg ctcagcctgg tcaaattcct ggtggatccg cccaacctcc tgctgatgga
     2701 cgagccgacc acccacctgg accttttgtc cgtagaagcc ctggtgcagg ctctgaagca
     2761 ttatgaagga acactggtct tcatctccca cgatgtgcac ttcatccgtt ccctggcaca
     2821 aaaaaccctg catgtgaacc gggggaccat caccgcctac gcaggcggat atgactacta
     2881 tctggaaaag tcaggcattc tggacgatga aaaaggcggc atcacggcgg aataaggctc
     2941 tttttcagtt tccccttttt ccttgccgtg gatttcatcc tgccttaaaa gaacaggatg
     3001 aaggcttttc ttgttcctct cttatattct gcgcttctgt ccggagcctc tcttgcattt
     3061 ggtgaaacgg ccgccggaac ggcttccccc gcagcagcgg ctccggcgga aaaaattcct
     3121 tccgcggaat ccctgatcaa ccaggccttt tcctttgcca tcaatatcca gcagacgttg
     3181 gcaggcgttc aggacaagga aagcgcggac aacgccgtca aaacgctgca ggacattcag
     3241 aaggacatcc ggcatttcct ccagcttcag gataaattga acgatgcgga aaaggagaaa
     3301 gaagacgccc tgatggaaaa aatggaaaaa cgaatggaaa tgctggacaa ccgctgcagg
     3361 caggaaggca aacgcctgtt tgaggcccgc tattacggtt ccgccgcctt aaaggacatt
     3421 ttggaaaatt cggatgaatt cagcgacctg gcagaaccgg atgaagacgg tgcgcccccc
     3481 ggtgcactcc gggaaaatga agaggccgga cagtagcccc ccgccccgtt tctccccccc
     3541 ttttttcatt cccggcacgc cctttccccg tatgggttcc tgcgcggcca agtccatttc
     3601 aagcttgccg gaaccgtgaa aaacgggttt actgtgggca gcatgcaaaa gttagcaggt
     3661 aaaacagcca tcgttaccgg cgcgggccgc ggaatcggca atgccgtcgc gcgccgcttc
     3721 gcttcggaag gagccagggt catcctgatc agccgcagtc catccagctg cgggggggcc
     3781 gcagaagaaa tcaacaagga atttccggat tcctgcaagg cctacccctg cgacgtagcg
     3841 gattacgcgg ccgttcagga aaccatggcc gccattttga aagacttccc gcagattgac
     3901 atcctggtga acaacgccgg catcacgcgg gactccctga tgctccgcat gaaagaggaa
     3961 gactgggatg ccgttctgga caccaacctg aaaagcgcgt tcaatacggt caaggccctc
     4021 cagcgcgttc tcatgaaatc cccggccggg cgcatcatca acatgagctc cgtcatcggt
     4081 ctcgtcggca acatcggcca ggccaattac gccgcttcca aggcgggcct catcggtttc
     4141 accaaatcac tggctcagga attcgctccg cgcaaagtca cgtgcaacgc cattgctccc
     4201 ggcttcatct ccacggaaat gtccaatgcc attcccgaca atctcaagga agaaatcgtt
     4261 aagaaaatac ctttgaaaga acaaggttcc gtggaagata tcgccgccct gacggccttc
     4321 cttgcctctg acgatgcccg ttacatcacc gggcaggtca ttgcctgcga cggaggcatg
     4381 acgatgtagg gcattccggt tttcaccatt ccatgcgcgg cattttcctt gtttcctgct
     4441 ttctgggagg aagcgtcctg ctggccgggt gccgggaaga aaataattcc ccccgcccgg
     4501 ccacggaaga tgccgcgcgc attaccagcg cacgccagtg gggagaaagc cgatccgcgc
     4561 tgcaaaaacg ggaactggac cgcgctgccg gtcctgccct tcccattccg gatgacctgc
     4621 cgtcccggga gctggtcggc acgacgcgcc aaatccatca gctcattgaa gcttccggaa
     4681 atccggcacg ttttgaatcc tacacggaaa cggttcccgc ggcgggagct tccctgcgca
     4741 tggtcgccat accgggagga acgttcctca tggggagtac cgcggaagag ccgcaccgga
     4801 aaccggacga aggaccgcag cataaagtga gcatctctcc cttctggatc tcggaaacgg
     4861 aaatcccctg ggaactttat acggccttca tggaaaacgg gcgtccgcgc gccaaggacg
     4921 gtcagcttct ggaggaacag ccggatgacg aactgtggga ctccgttacg cagcctaccg
     4981 ccccctacac cgccatgaac ctgggcatgg gtcacggcta tgaacacggt ctgcccgcca
     5041 tctccatgtc ccaccacgcc gccagcaaat tctgcgaatg gctgagcgcc cagaccgggc
     5101 attactaccg cctgcccacg gaggcggaat gggaatacgc ctgccgggcc ggctcccccg
     5161 gcgcctattc ttacggaaac ggggaagcct ctctggacca gtacgcctgg tactggaaca
     5221 actccaatga ccgctaccag aaaacaggct ctaaaaaacc aaataagtgg ggactccggg
     5281 acatgcacgg aaatgtggcg gaatgggttt tggactctta cgttccggat gcctacggca
     5341 aacggagcgg cttgcccgcg aaagaccccc tggtcatcat ccccggcgcc cctcacatcg
     5401 ttcgcggcgg ttcgtgggaa gacgacccgg acagcctgag aagcgctgcg cgccgcgcca
     5461 gcacccctgc ctggaaccgt caggatcctc aaaaccctaa aagcatctgg tacctgacgg
     5521 acggaggcat gatcgggttc cgcgtggtgc gccccatgaa cattccggac gttatgacga
     5581 tgcaccgcct ctggaatttc tccaaggggg agccgtaaag aacaaccctt catgatcatt
     5641 gcattaagaa cggaacatgt cacgagagaa gcgctctgga actatttcgt ccccggctgc
     5701 aatgaacatt acctgctcca tatcatgcgc gtcagtcctt ccttcatccc ggagctggat
     5761 acagtcgccg tccacggcag ccgcatcgtc gggaaacatc gttgatgcaa cgtccgtcat
     5821 cagggcagac gatggaaaag aatatgaagt gctgggcatg gggcccattg ccgttcttcc
     5881 gaaataccag cgccggggaa taggacggcg aataatatgt atgcggcggc cctccaggtc
     5941 tgtgagctgc aaagggggtc cctatccggc ctgaaaggcc gctatgtgaa agctactgtg
     6001 taccatatgg acgaaaagcg cgctgccgaa tttgacggca ttttccggta aagaaaaagc
     6061 tttccggtac tgcgtctcaa aaacgtttcc agcaaattgc cgccatgcgg aaaaaaccgg
     6121 atacggcccc ctgcccccgg aaattccgta ccttccggag ggcatgaatc ccgcatacgg
     6181 ataagcaatt cttcctctct ggatataaaa aacaagagct gttccgcaag aacagctctc
     6241 atccgccgat ttttcgccat caggaagctc aagccctgcg gcggcgcatc atcagcgcgg
     6301 ccagtcccag caggcccagg gaaaccgtgg ctggttccgg caccatttcc cctcggattt
     6361 ccgtgaaaat cggggataat aagctgaaag tattggttcc gttggctccc gtaataacga
     6421 cagaatcacc aggcgctccc tcggcgtcat aatggccgcg gatgccggga gcagtcaatc
     6481 cgccgctgat cgttacggta tctccttccg tgttagcagt aggggcggct gttccccccg
     6541 cagcatataa atacgtttta gacgtatcct gcatcaagtc catcacggac tggctcacgg
     6601 ccaggaaacg gtatgtcaat gccgcgtcaa gaagcagggg agaaccatcc agggaagaaa
     6661 aactgaacgt cagattaatc cctgctgcag tagttcccgt attggtgctc cagccgatga
     6721 ccgaattgtc ggagccattc agcaccagga agccgtaagt gacattagcg cccaaaccgt
     6781 tggcggctcc gcgcagcgta aaactgtcca gtctgatctc tccggacagg gaggagggag
     6841 aagaggaatc ggaaggagcc agggaagaag accccaggcc aagataaaac ccatggatgg
     6901 tactattgta attatccgta ccgggagtgt aataattaaa aacggtcgct gcctccgagg
     6961 aaacagcaaa gcttcccatc gcgattaaaa atgtcagtgt tttcttcata tttattattc
     7021 cttttggatg gcaacttgta gcgaatttgg aattccccaa tcggatttgg aatccgtcaa
     7081 gtaatgaaaa agaggccaaa tcaatcatga aaccaatgaa taacaaagac tgacccgtca
     7141 tcttagcaaa aggaccagag atattaaaaa atcattattt tcaatgaatt ataaatacaa
     7201 tatactaact cttaatattt ttaattgctt gcggattcca aattcgttat tcaagcacaa
     7261 gtacatacat tgaatcttgc atcattttat taagatactg accatgaata aattattatc
     7321 caccctgatt ctttcggccg gcatgagcct aagcgctacc gcggctacct ctctgctgga
     7381 tagctccatc gtgggatatt cggactttgc ctcccaaacg gcggatttcg gcaccctgaa
     7441 agattccgtt tccatcacgt ctgacgacag caatctgacg ttatccggga taaccttcaa
     7501 cggatacggt gccaacaacc gcgacgttat gtctgtgacg atggttcttg acctgaccaa
     7561 aatcaacact ccggacgcct ataccgctct gtttaacgcc aaaaacagca gtgtaagctg
     7621 gggcgtgggc ctgaacacgg accggaaact ccagggatta tggaacaaca cctcatacaa
     7681 cgggcccgtc gttgacaccc cgctgggcac ggaaggttcc ctgaccattt ccgtagtcac
     7741 cggagatctt ggcacccgca tctattttgg agacagcgct acgtactatt ccaacagcgg
     7801 cctgaaattc ggcaaccagc aaattgatca gattctcatg gacgcaggac tggctgaatc
     7861 catcgaacag ctctacatcc acgactccct cctttcccag gaacaagttg gtcaactgat
     7921 gagtgaaatc gccagcatcc cggaacccgc cacggcttcc ctgggcctgc tgggactggc
     7981 cgcgctgatg atgcgccgcc gcagggcata agcctgtacc gtccgcctcc ctatattcaa
     8041 aggccggctc acaaaatcgt gagccggcct tttccttatc cgttcaaaca tctgccggaa
     8101 aaaacagggg ggaagaagct tccatttgct gcggtaccct cacggccagc acttgacggg
     8161 gaaatggcat tcaggctccc ccgggagggt catttcaaga gcttccggcc ccgccccact
     8221 tccgtacacg cccctttttc ccatgccggg acagccggaa ccggagcatg caaagcccgg
     8281 cttccctcag catccggaac agcccatcct ttcagcaatc catttccccg cacggtccgg
     8341 atcgctgcgg tttccgtccg tcggcaacag actccttccc cgaaacaggg aaaaggagtg
     8401 ggaaaatggc cgagcttgaa cctttatccc ccgttcccgt ccatgaacct tcaaaaacag
     8461 cagctgctac tgcgcctgtt ccggtatttc aaaagcagaa aaggagaacc gcgttttttc
     8521 aacaaacgga atatatgcct tctggccgcc gccggcgcct acatcctgac tcccgacgaa
     8581 ttcctgtttg acggaatcgg caggctgggc cttctggatg acgcggcggt catcctgggc
     8641 gccgtcctca ccgtcttttt cccggacggg gactagaggg ccgtaccctc cgccgcgcct
     8701 cgggcggaat tagcgggacg acactttccg gaacttcggg gactgtccca tgaatgtctc
     8761 cggattttcc aggagaagac gttccgtttc ctgccgggaa aaaccgcgcc tgcgcagctc
     8821 gcaggccagg gccgtcagcg ccaggggatc ggaatccccc cagtccgccg cggaattggc
     8881 ccagacacgg tccattccgt acaattccag aatatccccc gcccgcttgg gattcagctt
     8941 actggtggga taaagggtca gcccggccca gtaaccggcc tccttcacca gcgggaaggt
     9001 atgttcctca cagtgatcca ccagcacgcg gcaagggtcc agatccggac ggtttttcag
     9061 ggcggaaaga atcattacgg tccccttaag cttgtcttcc agatggggag tgtgaatcag
     9121 cacaagctgg ttgaggcgca ccgccagatc cagatgctct tcaaaaatag tcatttcatg
     9181 ggaagtattc cggttcagcc ctatttcccc gatgccgagg acattgggcc ggtcaatgaa
     9241 ctccggaatc agtttcatca catcccgcgc gaaagccacg tcctgcgcct ccttgggatt
     9301 gatgcacagc catgtgtaat ggtccatgcc gaacttggcc gccctggcgg gttcgcattc
     9361 cgtaagctgt acgaaataat cccggaaacc gtccgcggac gaacggtcgt aaccggccca
     9421 gaacgccggt tcccctaccg ccaggcagcc ggcctgcgcc atggcccggt attcgtccgt
     9481 ggtgcggcac accatatgta tatgaggttc tatgaaagcc atcattctta tttgctgagg
     9541 ttcggggctc cgcaggccgc tttggctgcg gcggtttccg gcacggtgtc atccctgtag
     9601 gaaagggctt ccagaatggc ccggacgcgt ccggggccgg atgcggacaa gaggggaaga
     9661 acatccatca gggcatggta gcggaaatcc gcctcccctt ccccgcggtc cacccggtcc
     9721 agaaatgcgg ccacatccag aacgccggcg cgcgccgctg cgaaatccgc gtccagcacc
     9781 tcctttttac ttcttttcat gcacagacga tacgcctatg cggaaagcct cgtcaagccg
     9841 gaacaggcaa caaaatgata accattccaa actgataaac agcaacctct ttccccggtt
     9901 tttcaaaaat ccgaaaagcg ccggaaattc aagaagaggc ttgccatccg ggcttgaacc
     9961 gggcatcctg tgaagacgca tttatttcat tagagcgcct atgaatgcac tagtaaaaac
    10021 catatgtaca ttcgtgacat cctccatcgg ccgcaaaatc attgtggctc tgacggggtt
    10081 atgtttggtc ttgttccttg cgggacacct ggcaggcaac cttctcatct tcggaggccc
    10141 tgaatggatc aacacctacg cccacggcct gcactccatg ccggaagcag ccctctgggg
    10201 aatccgcgcg gggcttgcgg tgatcttcat catccacgtc tggctgacca tccagctgaa
    10261 gctggaaaac catgcggccc gcgaacccta cgtgttcaag aacaccatta aggcaacgct
    10321 ctcctcccgc tacatgatct ataccggttt gaccgtcctg gtgttcctga tctaccacct
    10381 gtaccagtac accctgcgcg tgggatacga ccccgcccag ttcaccacct tcatttccga
    10441 cggtacggtg gaaacctttg acgtgtacaa gatgatcgtg accggattct ccaacgtatg
    10501 gtgctccgcc ttctacatcc tggccgttct gatgctgttc agccatctgc gccacggggt
    10561 acagtccatc ttccagactg tgggcgtcga ttcccgcaaa atccggccct tctacaactt
    10621 tatcgccatc gcctacggcg cgattatctg cctgggcttc atctccgtgc cggtctcggt
    10681 tcttctgggt atcatcaaat aaccatcaac tcctctcaaa gtcatgatta attttcccgt
    10741 aagcgactgg atgccggatg ccaaaattcc ctccggccct attcaggaca aatggtccaa
    10801 atacaaactt gagtccaaac tgatcaatcc gaacaacaag cgcaagtaca cggtacttgt
    10861 ggtaggttcc ggcctggctg gcgcctccgc tgccgccacg cttgccgaac ttggctacaa
    10921 cgtcaaatgc ttctgctacc aggacagccc ccgccgcgcc cactccattg cggcccaggg
    10981 cggcattaac gcggccaaga actaccagaa cgacggcgac tccgtttacc gcctgtttta
    11041 cgacaccgtt aaaggcggcg acttccgcgc ccgtgaagcc aatgtctacc gtctggcgga
    11101 agtctcctcc aacatcattg accagtgtgt ggcccagggc gttcccttcg gccgtgaata
    11161 cggcggcctg ctggacaacc gctccttcgg cggcgcccag ctcaagcgaa ccttctacgc
    11221 acgcggacag acgggccagc agctcctgct gggtgcctac caggccctgg aaaaggaagt
    11281 ggccaaggga cacattgaaa tgttctcccg ccatgaaatg atggatctgg tgctggtgga
    11341 cggcgaagcc aagggcatcg tcacccgcaa tctggttacc ggcgaaatca aatcctacgc
    11401 aggggatacc gtcctgctct gcacgggcgg ctacggcaac gtgttcttcc tgtccaccaa
    11461 cgcgatgggt tgcaacgtca ctgccgccta caaagcctac aagcgtggtg ccttcttcgc
    11521 caacccctgc ttcacgcaaa tccaccccac ctgcattccg gtcaaaggcg actaccagtc
    11581 caaactgacg ctgatgtcgg aatccctccg caacagcggc cgcatctggg tgcccaagtc
    11641 ccgtgaaacc gcagaaaaaa tccgtaagaa ggaaatcaag ccttccgatg ttcccgaaga
    11701 agaacgggac tactacctgg aacgcaagta tccctccttc ggcaacctgg ctccgcgcga
    11761 catttcctcc cgcgccgcca aggaagcctg cgacgacggc cgcggcgtgg ccgtcaccgg
    11821 caagggcgtc ttcctggatt ttgcggatga aatcaagcgc atgggccgcg aatggattga
    11881 cggccaatac ggcaatctgt ttgacatgta cgaagaaatc acggacgacg acccccatga
    11941 aacgcccatg atgatctacc ccgcctccca ctacaccatg ggcggcctgt gggtggacta
    12001 caacctcatg tccaacgtga aggggttgca cgtcctcggt gaagccaact tctccgacca
    12061 cggcgccaac cgcctgggag cctccgccct gatgcagggc ctgtctgacg gctacttcgt
    12121 cattcccgcc acgctgcccg cttacctgac gaccaccaag cccggtgccg tcaccaccgc
    12181 cgccccggaa ttcaaggctg cggaagacga agtgaaggaa cgcatcaaca agctcctgaa
    12241 tgtgaagggc accaagacgg tggactcctt ccaccgggaa ctgggcctca tcatgtggga
    12301 agactgcggc atggcccgca cggaagaaag cctgacccac gccattgaac gcattcccca
    12361 gctccgcaag gaattctggg aaaacgtgcg cgtaaccggc acggcggacg gcatcaacgc
    12421 ggaactggaa aaagcctgcc gcgtggccga cttcctggaa ttcgcccagc tgctctgcta
    12481 tgacgccctg aaccgccagg aatcctgcgg cgcccacttc cgcgtggaat accagctgcc
    12541 ggacggcgaa gccaagcgca acgacgatga atacgcctat gtagccgcct gggaatacac
    12601 tggcgtggac agcctgcctg ttctccacaa ggaaccgctg accttcgaga acgtgcacct
    12661 tgccatccgc agctacaagt aaagatagcc aatacattaa cactcaaaag aaagattata
    12721 acatggctaa aacactcaat ctcactctca aggtctggcg ccaggaaaac cgggaagcca
    12781 agggccgcat tgagacctat gccgccaagg acattccggt ggacgcctcc ttcctggaaa
    12841 tgctggacat cgtcaatgaa ggcctggtca aggaaggcaa ggaacccatc cattttgacc
    12901 acgactgccg ggaaggcatc tgcggcatgt gctccctgac catcaacggc attccccacg
    12961 ggccggaacg ccaggtgacc acttgccagc ttcacatgcg caagttcaag gacggcgata
    13021 ccgtctggat tgaacccttc cgcgcgaagg ctttcccaat cctgcgggac ctgatggtgg
    13081 accgctccgc cctggaccgc atcatcgccg ccggaggcta tattgacgtg cgtaccggtt
    13141 ccgcgccgaa cgccaacaac atcgccgtgg aaaaagtgaa ggcggacgcc gcctttgacg
    13201 cggccgcctg catcggctgc ggcgcctgcg tggcctcctg taaaaacgcc tccgccatgc
    13261 tgttcacctc cgccaagatc gcccatctca atctgctgcc gcagggccag ccggaacgtt
    13321 ccaagcgcgt cctggccatg atgaagcaaa tggaagcgga aggcttcggc aactgcacga
    13381 accagtatga atgtgaagct gcttgcccga aaggcatcag cgtggacaac atcgcccgcc
    13441 tcaaccgcga cttcatgcga gccaacgcca aggaaggtct ctgtttctaa agaagattcc
    13501 ttcttaagac gctctgtaaa aactcccggc ggcatcggct gtcgggagtt tttttcatta
    13561 tcaggtttcc ttgaaccagg aataaaatat cagacagttg cttcctcatc gtcgcgcagc
    13621 gtaaaaaata aatgttacac tggaaggttc ccagtaatcc aggagactgt acttggaaat
    13681 gccggacgaa acctaagcaa gcccccttcc gacagcgacg gcccccatct ttcttcgaga
    13741 gaaagaaaca ttgattacag gaattagact gatgcccgga agggatggca tcctgtcaag
    13801 ggctcagcat gagagggaaa cattttctaa caaacagaca acattgatgt ctattaaggg
    13861 aatgcactga acgtaagaat tataatatta tcttttcgtg taaaataatg accatctttt
    13921 ataaaaaatc aaaaacatac aaataaaatt ctatcgacac cgacttcgga tcatactatt
    13981 gataaaacga tcaggaaagg gcggccaccc ctcgcttcat tcattactcc caactcttga
    14041 atacctgatg aatccgcctc atcgttcctc ctccgcccat cgttctgccg ttcccgctta
    14101 ccggaaatgg tactttggtt ccggtgccag ccaatccggc tctactcgcc gcgtgcgctt
    14161 atccggccag ccggatcccg atccgctgcc gtttgaagcg atccggatcc atgaggaaag
    14221 gaaagtgggg ccgccgagca cgtcggcgga cgggcacagc gcgcacggga cattcaccat
    14281 cccggaagga gcggagggca aaaaactcta cggcacctgc tcgctcttcc ttggggtgga
    14341 cgactgggga atcctggagg tgaaggactc cggcggcaac gtggtggcgc aggtggatct
    14401 gaaagaaaac ccgcagacgg cgggcgaaca gggcgggcac aaataccaca cggggactgg
    14461 cggggcgcag ctcccctccg gcacctacag ctgggaagtc agccagacca acatcgacta
    14521 caatccggca agcggcaaca cctccatctg caactacagc atcgacgtgg tgccgacgga
    14581 accggggggc aggaaagaac ccgaaccgtg tccctgcgag ggagacacgt gcgacaacag
    14641 cggcggaacg ccgccctccc cgccgcaggc ccggtcgtgc cctgaggcgg gcatggaaag
    14701 cggcgccctg ggaaactaca gctcggcggg gtgcagcgtg acggcggaaa gcacggccac
    14761 gctgatgtac tggtcctgca acttcggagc gttccgtgga cttgggggcc ttccggccgg
    14821 aagggtggaa ctgagggctg aacaaaacgt ctccggcctg gaaagcccct cctcgctggc
    14881 ctacaaccat cccctgaaca gccgtctgga cgtgccggaa gggggcattg cgccgggagt
    14941 gcggttcaac ctggtgcagg gagaccgggt gattgccatg cgctgctaca cggacgggtc
    15001 cgtgctgccc atcggggtgg acacgtcggg cggagggcgt gcggcgctgg ccacggtgga
    15061 aggacaatcc tgcctgcgct gggtggtgga agacggcagc caatacctct tctcggcgga
    15121 aacgggaacg ctcctctcct acaccaccac ggacaggcag g
//
