GCA_902505535.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaPBECPFDC_1 (original name was: gnl|Prokka|PBECPFDC_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	lanthipeptide-class-ii,RiPP-like	2,864	35,569	microvionin	RiPP	8%

gnlProkkaPBECPFDC_2 (original name was: gnl|Prokka|PBECPFDC_2)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	nucleoside	19,640	40,938

gnlProkkaPBECPFDC_12 (original name was: gnl|Prokka|PBECPFDC_12)

Region	Type	From	To	Most similar known cluster		Similarity
Region 11.1	NRPS-like	274,059	317,070	nosiheptide	RiPP:Thiopeptide	7%

gnlProkkaPBECPFDC_23 (original name was: gnl|Prokka|PBECPFDC_23)

Region	Type	From	To	Most similar known cluster		Similarity
Region 12.1	RiPP-like	32,337	42,729

No secondary metabolite regions were found in these records:: gnlProkkaPBECPFDC_3 (original name was: gnl|Prokka|PBECPFDC_3); gnlProkkaPBECPFDC_4 (original name was: gnl|Prokka|PBECPFDC_4); gnlProkkaPBECPFDC_5 (original name was: gnl|Prokka|PBECPFDC_5); gnlProkkaPBECPFDC_6 (original name was: gnl|Prokka|PBECPFDC_6); gnlProkkaPBECPFDC_7 (original name was: gnl|Prokka|PBECPFDC_7); gnlProkkaPBECPFDC_8 (original name was: gnl|Prokka|PBECPFDC_8); gnlProkkaPBECPFDC_9 (original name was: gnl|Prokka|PBECPFDC_9); gnlProkkaPBECPFDC_10 (original name was: gnl|Prokka|PBECPFDC_10); gnlProkkaPBECPFDC_25 (original name was: gnl|Prokka|PBECPFDC_25); gnlProkkaPBECPFDC_26 (original name was: gnl|Prokka|PBECPFDC_26); gnlProkkaPBECPFDC_27 (original name was: gnl|Prokka|PBECPFDC_27); gnlProkkaPBECPFDC_28 (original name was: gnl|Prokka|PBECPFDC_28); gnlProkkaPBECPFDC_29 (original name was: gnl|Prokka|PBECPFDC_29); gnlProkkaPBECPFDC_30 (original name was: gnl|Prokka|PBECPFDC_30)

Compact view

gnlProkkaPBECPFDC_1 - Region 1 - RiPP-like,lanthipeptide-class-ii

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Location: 2,864 - 35,569 nt. (total: 32,706 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_13

ctg1_21

Leader:

MVTLKNDNVVGDRGDGAAAA

Core:

VGSARELVDGLVSSGRWIPCSSG

Core with dehydrations:

VGDhaARELVDGLVDhaDhaGRWIPCysDhaDhaG

antiSMASH-DB 4.0 matches for ctg1_21

100.0% NZ_CABWKH010000001.1and 1 other:

NZ_CP010411.1 Lanthipeptides: RY67_RS05310_lanthipeptide

Lanthipeptides: BIFLH14_RS13125_lanthipeptide

VGSARELVDGLVSSGRWIPCSSG

18.8% NZ_CP031746.1: Lanthipeptides: allorf_1813979_1814164_lanthipeptide

LVSSGRWIPCS

+V RW+PCS

VVGCARWVPCS

allorf_004703_004852

Leader:

MACSALVVPAA

Core:

RAGMLVSFFLLLAYRLTCRREANVFGDRRYFLVLGRAA

Core with dehydrations:

RAGMLVDhaFFLLLAYRLDhbCysRREANVFGDRRYFLVLGRAA

antiSMASH-DB 4.0 matches for allorf_004703_004852

100.0% NZ_CABWKH010000001.1: Lanthipeptides: allorf_004703_004852_lanthipeptide

RAGMLVSFFLLLAYRLTCRREANVFGDRRYFLVLGRAA

21.1% NZ_SGWQ01000010.1: Lassopeptides: EV193_RS25540_lassopeptide

ANVFGDRRYFLVLGRAA

+GD R FL GRA

CTPWGDCRDFLGCGRAP

16.7% NZ_CP077072.1: Lanthipeptides: allorf_2556081_2556245_lanthipeptide

VFGDRRYFLVLGRAA

V G+R+ +V GRA

VSGERKLSVVPGRAG

with 1 more sequence matches

15.1% NZ_CP023466.1: Lanthipeptides: allorf_0909586_0909777_lanthipeptide

RAGMLVSFFLLL

RAG+ S FLLL

RAGVACSIFLLL

allorf_011277_011396

Leader:

MRPAFRVGEPGA

Core:

ITTTSRPTPATKSSSHCSRARICLQPQ

Core with dehydrations:

IDhbDhbDhbDhaRPDhbPADhbKDhaDhaDhaHCysDhaRARICysLQPQ

MIBiG 3.1 matches for allorf_011277_011396

18.5% BGC0002110 (QKV49894.1): Lanthipeptide: birimositide

PATKSSSHC

P TK +S C

PTTKCTSKC

13.5% BGC0001229 (SBI_06989): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

PATKSSSHC

P TK +S C

PTTKCTSRC

antiSMASH-DB 4.0 matches for allorf_011277_011396

100.0% NZ_CABWKH010000001.1: Lanthipeptides: allorf_011277_011396_lanthipeptide

ITTTSRPTPATKSSSHCSRARICLQPQ

25.9% NC_018750.1and 1 other:

NZ_CP029196.1 Lanthipeptides: allorf_0617083_0617295_lanthipeptide

Lanthipeptides: allorf_0633794_0634006_lanthipeptide

TTTSRPTPATKSSSHCSRA

RPTP S C R+

DDADRPTPGRNEGSWCPRS

14.0% NZ_LT607411.1: Lanthipeptides: allorf_4738370_4738597_lanthipeptide

RPTPATKSSSHCS

RPT T+S HC

RPTTVTRSRHHCG

allorf_021961_022158

Leader:

MHGPIRVIRRDGVTLGG

Core:

PQHAQHEQRGRGGKPVDQHAARFPQFQRSIAHISYPRLRSAYIACVSV

Core with dehydrations:

PQHAQHEQRGRGGKPVDQHAARFPQFQRDhaIAHIDhaYPRLRDhaAYIACysVDhaV

antiSMASH-DB 4.0 matches for allorf_021961_022158

100.0% NZ_CABWKH010000001.1and 1 other:

NZ_CP010411.1 Lanthipeptides: allorf_1259774_1259971_lanthipeptide

Lanthipeptides: allorf_021961_022158_lanthipeptide

PQHAQHEQRGRGGKPVDQHAARFPQFQRSIAHISYPRLRSAYIACVSV

17.9% NZ_AP018172.1: Lanthipeptides: allorf_1980623_1980829_lanthipeptide

EQRGRGGKPVDQHAARFPQFQRSIAHISYPRLRSA

+Q G GG P +Q FP + ++ PR +

KQCGLGGLPHEQLPKGFPGLKEAVRCGGSPRCSNC

14.6% NZ_JAAZQN010000004.1: Lassopeptides: FHW94_RS14590_lassopeptide

GRGGKPVDQHAARF

G GG PVD++ +F

GAGGIPVDENLGQF

with 1 more sequence matches

13.6% NZ_CP025394.1and 1 other:

NZ_CP025394.1 Lanthipeptides: allorf_1695292_1695519_lanthipeptide

Lanthipeptides: allorf_1695292_1695519_lanthipeptide

QHEQRGRGGKPVDQHAARFPQFQRSIAHISYP

+ + RG G P Q A R P + ++ P

EGDGRGTAGTPTRQSAVRHPPQPPNCGPLAAP

allorf_022137_022208

Leader:

MPPARTAAASGM

Core:

STIGVCMAQYE

Core with dehydrations:

DhaDhbIGVCysMAQYE

antiSMASH-DB 4.0 matches for allorf_022137_022208

100.0% NZ_CABWKH010000001.1and 1 other:

NZ_CP010411.1 Lanthipeptides: allorf_1259724_1259795_lanthipeptide

Lanthipeptides: allorf_022137_022208_lanthipeptide

STIGVCMAQYE

allorf_022146_022298

Leader:

MGHAHTNRAHAAGG

Core:

GRPCRWHRAGLAVRETRMGDGRSACPRVAAGSCRRG

Core with dehydrations:

GRPCysRWHRAGLAVREDhbRMGDGRDhaACysPRVAAGDhaCysRRG

antiSMASH-DB 4.0 matches for allorf_022146_022298

100.0% NZ_CABWKH010000001.1and 1 other:

NZ_CP010411.1 Lanthipeptides: allorf_1259634_1259786_lanthipeptide

Lanthipeptides: allorf_022146_022298_lanthipeptide

GRPCRWHRAGLAVRETRMGDGRSACPRVAAGSCRRG

30.6% NZ_RYYV01000004.1: Lanthipeptides: allorf_104369_104572_lanthipeptide

WHRAGLAVRETRMGDGRSACPRVAAGSC

W+R L R T G GR+ C R +C

WYRNTLRSRST-AGKGRNTCLRRQVHAC

26.3% NZ_CP119804.1: Lanthipeptides: P2T57_RS09790_lanthipeptide

GRPCRWHRAGLAVRETRMGDGRSACPR

G C W AG RE GD C

GDDCSWCSAGTLAREEFKGDDAVVCDE

with 2 more sequence matches

25.0% NZ_JALBFU010000008.1: Lanthipeptides: allorf_86167_86340_lanthipeptide

CRWHRAGLAVRETRMGDG

CR R GLA+ TR+ G

CRPARHGLALPPTRIASG

16.7% NZ_CP077072.1: Lanthipeptides: allorf_2556044_2556175_lanthipeptide

PCRWHRAG

PC W RAG

PCSWSRAG

allorf_024255_024410

Leader:

MGKLPPHGIFTASWMYGS

Core:

RRPNCLVPPITMFGRLRWSGPGRRFGMTFLPCR

Core with dehydrations:

RRPNCysLVPPIDhbMFGRLRWDhaGPGRRFGMDhbFLPCysR

antiSMASH-DB 4.0 matches for allorf_024255_024410

100.0% NZ_CABWKH010000001.1: Lanthipeptides: allorf_024255_024410_lanthipeptide

RRPNCLVPPITMFGRLRWSGPGRRFGMTFLPCR

18.2% NZ_FMUR01000003.1: Lanthipeptides: allorf_188176_188259_lanthipeptide

RPNCLVPPITMFGRL

R +C++P I GR+

RISCILPLIIFMGRI

15.2% NZ_CP033875.1: Lassopeptides: allorf_0475837_0476004_lassopeptide

FGRLRWSGPGRRFGM

FG++ P R+G+

FGQIEAEDPSDRYGV

allorf_025661_025900

Leader:

MHTSFSSLKDHRLTYFRTTWHHFRAISGLQGA

Core:

DLRLSGHLPPFQGALHPRKRKYKRLCFNAIKPFWGRVYFGNSPLKRR

Core with dehydrations:

DLRLDhaGHLPPFQGALHPRKRKYKRLCysFNAIKPFWGRVYFGNDhaPLKRR

antiSMASH-DB 4.0 matches for allorf_025661_025900

19.1% NZ_CP017316.1: Lanthipeptides: allorf_6268660_6268842_lanthipeptide

RLSGHLPPFQGALHPRKRKYKRL

R +GH P QG H R+ + R

RGAGHAP-CQGVCHQREERADRA

17.0% NZ_CAJHJS010000009.1: Lanthipeptides: allorf_72861_73019_lanthipeptide

PRKRKYKRLCFNAIKPFWGRVYFGN

+ K++ C N IK V F N

DKTAKHRNFCVNLIKSELFLVTFSN

17.0% NZ_CP069396.1: Lanthipeptides: allorf_00880550_00880726_lanthipeptide

LCFNAIKPFWGRVYFGNS

+CFN+ + GR + GNS

VCFNSHRAGNGRAHEGNS

with 2 more sequence matches

14.9% NZ_KV815277.1: Lanthipeptides: allorf_240790_240948_lanthipeptide

CFNAIKPFWGRVYFGNSPLK

C N++ WG N LK

CLNSVIKIWGDTINFNLSLK

12.8% NZ_JAHXMW010000012.1and 1 other:

NZ_JAHXMW010000012.1 Lanthipeptides: allorf_053850_054050_lanthipeptide

Lanthipeptides: allorf_053850_054050_lanthipeptide

WGRVYFGNSPLK

W + Y GNS L

WNKAYVGNSLLN

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg1_21 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 2241.2 Da

Molecular weight: 2242.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2260.5 Da N = 1; 2278.5 Da N = 2; 2296.6 Da N = 3; 2314.6 Da N = 4

allorf_004703_004852 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 4384.4 Da

Molecular weight: 4387.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4405.2 Da N = 1

allorf_011277_011396 - Class II

Cleavage pHMM score: -3.50

RODEO score: 0

Monoisotopic mass: 2746.5 Da

Molecular weight: 2748.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2766.1 Da N = 1; 2784.1 Da N = 2; 2802.2 Da N = 3; 2820.2 Da N = 4; 2838.2 Da N = 5; 2856.2 Da N = 6; 2874.2 Da N = 7; 2892.3 Da N = 8

allorf_021961_022158 - Class II

Cleavage pHMM score: -3.70

RODEO score: 0

Monoisotopic mass: 5377.8 Da

Molecular weight: 5381.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5399.0 Da N = 1; 5417.0 Da N = 2; 5435.1 Da N = 3

allorf_022137_022208 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 1164.5 Da

Molecular weight: 1165.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1183.3 Da N = 1

allorf_022146_022298 - Class II

Cleavage pHMM score: -4.40

RODEO score: 0

Monoisotopic mass: 3853.9 Da

Molecular weight: 3856.4 Da

Number of bridges: 3

allorf_024255_024410 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 3820.0 Da

Molecular weight: 3822.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3840.6 Da N = 1

allorf_025661_025900 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 5584.1 Da

Molecular weight: 5587.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5605.6 Da N = 1

gnlProkkaPBECPFDC_2 - Region 1 - nucleoside

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Location: 19,640 - 40,938 nt. (total: 21,299 nt) Show pHMM detection rules used

nucleoside: (LipM or LipV or LipU or ToyB or TunD or pur6 or pur10 or nikJ or nikO or truD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaPBECPFDC_12 - Region 1 - NRPS-like

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Location: 274,059 - 317,070 nt. (total: 43,012 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 274058 - 317070:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg11_266

AMP-binding (14..381): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFFTIGIIYK
Nearest Stachelhaus code(s):: Ile DFWNIGIIYK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

gnlProkkaPBECPFDC_23 - Region 1 - RiPP-like

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Location: 32,337 - 42,729 nt. (total: 10,393 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.