LOCUS       c00008_gnlPro..        14442 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KHGGBEAB_8.
ACCESSION   c00008_gnlPro..
VERSION     c00008_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 04:39:19
            Original ID  :: gnl|Prokka|KHGGBEAB_8
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14442
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14442
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[158:4442](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(159..4442)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14442
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14442
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(159..4442)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_1"
                     /sec_met_domain="HGD-D (E-value: 1.1e-59, bitscore: 194.8,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1.2e-37, bitscore:
                     121.9, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENNTLHKLGIDIGSTTVKVAILDQEDHLLFSDYERHFANIQETL
                     SSLLQKAYDALGDFAVAPMITGSGGLTLAKHLGVPFVQEVIAVSTALQHYAPQTDVAIE
                     LGGEDAKIIYFEGGNVEQRMNGICAGGTGSFIDQMASLIQTDATGLNEYAKNYKAIYPI
                     AARCGVFAKTDIQPLINEGATREDLSASIFQAVVNQTISGLACGKPIRGHVAFLGGPLH
                     FLSELKAAFIRTLNLDDEHAITPENSHLFAAIGSALNYKPGETTTLVSLRDRLSDGIKM
                     EFEVARMDPLFASQEEYDAFRARHDGHNVRSADFSTYEGNCYLGIDAGSTTTKIALVGE
                     DGSLLYSFYSNNNGSPLATAIRSIKEIYTLLPPKAKIVHSCSTGYGEALLKAALMLDDG
                     EVETVAHFYAAAFFDPEVDCILDIGGQDMKCIKIKNQTVDSVQLNEACSSGCGSFIETF
                     AKSLNYSVQDFAKEALFAKNPIDLGTRCTVFMNSKVKQAQKEGASVADISAGLAYSVIK
                     NALFKVIKLSDASQLGKNIVVQGGTFYNDAVLRSFEKIAGVECVRPDIAGIMGAFGAAL
                     IARERHEAGYQTSMLSIEQINALTFDTKLARCQGCTNHCLLTINRFSGNRQYITGNRCE
                     RGLGKEKNKDNIPNLYEYKNKRLFDYPPLSAEEAARGTVGIPRVLNMYENYPFWATFFK
                     KLGFSVVLSPQSTRKIYELGIDSIPSESECYPAKLAHGHVTWLIHQNVDFIFYPCIPYE
                     RNEFPDSNNHYNCPIVTSYAENIKNNVDEITSGQVKFLNPFMSFASEETLSSQLIKTFG
                     QSEFGIPESEIRDAVAEGWKELAVCRMEMQKKGEEVLQYLKETGRRGIVLAGRPYHVDP
                     EINHGIPELITSYGIAVLTEDSISHLQPVERPLIVMDQWMYHSRLYAAANYVKTRDDLD
                     LIQLNSFGCGLDAVTTDAVNDILTKSGKIYTCLKIDEVNNLGAARIRIRSLISAIRVRE
                     KKQTKRTIVPANYNRVVFTEEMRKNYTILCPQMSPIHFELLEPAFQTAGYNLVVPDVDS
                     RTCVDVGLKYVNNDACYPSLIVVGQLMAAVMSGDYDMSRTAILISQTGGGCRASNYIGF
                     IRRALEKAGYPDVPVISINLSGLEKNPGFKLTLPLIQHGLYALEFGDIFMRCVYATRPY
                     EAVAGSTDELHEKWKKEVIAFITQKKMLSHGKFKKMCREIIRDFDNLPRKDIKKPRVGV
                     VGEILVKFHPAANNHLVELLESEGAEAVVPDLTDFLLYCFYNTGFKADNLGMSQKSKKI
                     GRLGINFFEWLRSAARDEFTKSRHFTAPAHIDDLARYARDIVSEGNQTGEGWFLTGEML
                     ELIHTGTPNIVCTQPFACLPNHVVGKGVIKELRHRYPGSNIVAIDYDPGASEVNQLNRI
                     KLMLSTANKNLAKQNAPEQKDQAAG"
     CDS             4704..5561
                     /locus_tag="ctg8_2"
                     /transl_table=11
                     /translation="MNWLNKLERKFGNWAVPNLIVWLIGAYTIGFVLYQVNPSIIGLLM
                     LSPYHILHGQVWRLITWVFMPTDTNLVYLLIMALFYYQLGTTLERTWGTFRFNVYIFGG
                     MLFTVIGAFLLYGIMYLMNGGVTTEMLLIGTSFSTSYINMSIFLAFACMYPDMQVLLMF
                     IIPIKMKWMAAVYGVLIALSFFETGWAGRMAIFMSLLNFIIFFFSTRNLKRYTPHEVHR
                     RQKFKADMRRPQGYAGGAKHKCAVCGRTELDDPTLEFRFCSKCEGNYEYCQDHLFTHQH
                     IRMS"
     CDS             complement(5637..6737)
                     /locus_tag="ctg8_3"
                     /transl_table=11
                     /translation="MAGSTLGTLFKITTWGESHGKGVGVVIDGCPAGLSLCEADIQKFL
                     DRRKPGQSRYATPRKEDDAVEILSGVFEGKTTGTPISLVVFNRNQQSKDYSEIASYYRP
                     GHADYTFDQKYGFRDYRGGGRSSGRETIGRVAAGAVAVKILNELGITFITYTKSIGPIA
                     VSSDRFNFSEVTKNPLYMPDAEAAENAENYLDACMAELNSSGGIVECIIKGMPAGIGDP
                     VFEKLNANLAKAVMSIGAVKGFEIGDGFDVAKATGKNNNDAFVLGEDGRIAKATNHAGG
                     ILGGMSDGSDIILRAAIKPTPSIAATQRTVNQSGEEISVNIKGRHDPIIVPRAVVVVES
                     MAAITIVDALFSNMSARMDALKDFYS"
     CDS             6862..8187
                     /locus_tag="ctg8_4"
                     /transl_table=11
                     /translation="MIEKYLVKKITEPVDWKVTVPGSKSMTNRALLMAVLSAGTVRVEG
                     VLFSDDSRHFLACLVALGFTVEIEEEKKCVTVTGCGGRIPRGEAVIDVGSAGTAARFLA
                     AMLGFSDGCYEIRCSAQMKRRPMAELFDLLSGAGAKIIFLEEEGHLPVRITGCRYARAD
                     KTAGETPREFSLDITKSTQFLSALLLIAPMVPEGMKIHITSEKTDGSYIRITRKMMQEF
                     GVSVAFDGRDYEVPCRSSYRKETYMVEPDMSAACYFYAAAAVTGGRALVRHVHMDNTQG
                     DLRFLEVLEHMGCTADDTPEGVLVTGPADGALRGITVNMNDFSDQALTLAAIAPFADAP
                     VRIEGIGHIRGQECDRIHAIQTNLTALGIRCEEKETAATIYPGSPHGGSVETYDDHRVA
                     MAFSLVGLRTDGIVIENPACCRKTFENYFTVLNELTGKTVES"
     CDS             8292..9443
                     /locus_tag="ctg8_5"
                     /transl_table=11
                     /translation="MYELLKQEGRAKRGVFHTVHGDIQTPVFMNVGTVAAIKGAVSTED
                     LEQIKCQVELSNTYHLHVRTGDKLIKEVGGLHKFMSWNRPILTDSGGFQVFSLAGLRKI
                     KEEGVYFHSHIDGAKIFMGPEESMQIQSNLGSTIAMAFDECPPALAERKYVEDSVARTT
                     RWLERCKNEMQRLNGLEDTVNRHQMLFGINQGAIYTDIRIDHAKRISELDLDGYAVGGL
                     AVGETHEEMYHVLDETVPYLPVNKPTYLMGVGTPANILEGVERGIDFFDCVYPSRNGRH
                     GHVYTNQGKINLFNQKYEKDMRPIEEGCGCPTCRRYSRAYIRHLLKAKEMLGMRLCVLH
                     NLYFYNTMMEEIRDALDAGNFASYKEEKLYGMGQINREKEMAK"
     CDS             9554..9871
                     /locus_tag="ctg8_6"
                     /transl_table=11
                     /translation="MFSILATESASSAGWISMVVWLVILFAFMYFFMVRPQKKEQQKKN
                     SMLAELAVGDTVLTTSGFYGTVIDITDDTVIVEFGSNKNCRIPMQKAAISAVEKPEDVT
                     E"
     CDS             9960..12455
                     /locus_tag="ctg8_7"
                     /transl_table=11
                     /translation="MKSKKNTFVSRAAVGCVTTAIFLLLCIIKGIYPFGIATLDTVDFQ
                     SQWIPAYYHVWDVLHGDGSAFFDWRVGGGNNFAGVSAQFSLFSPFNLFFLFVKRSWIEK
                     SMIVFLLIKLLAMGYGMRWFLKEQILKEERYGIYILAGSVGYAVNGYTLLYYGMGWLDV
                     AAILPLLCYFFCRMAEREGDWCLGKNTLGYIVCLTLVFLINIPQAYMMCFFLIVFAGGY
                     FFLKRQDQPLKKNGILKFGLTSLLSLGIAAVIFLPAARAMLGSYRLSGEEYRGISGYFL
                     LLRQDGMDAVWKWVILGSVAVPLLFFVISGRRKREHIWQWYLVAAMVLPVFFEAVNLIW
                     HRGTYVCFPMRYGYMLVFAVICMAAARVPDFVGDSRVRRNILYAFLGIWCVQMVALGIS
                     LIQPETHTDETDFVGDATEIGRPLAGKTDVFHKAKLADGAIDNNYPLIAESTSYSNYLH
                     LMTSEQIRMNTLLGYSQVWTRLSDTGGTLASDIMLGYRYYVASKAGSWGKDTAADSLWP
                     LAETEKFTLWENAPVGDRAFFITKADYEAYAVTEAYTENVFENQNRLSELLFHTVPIDW
                     KKETYLDDQTGAELSCRFYADGKQILYLYGKDLQQAEITVNGERIYVPDYNDLYNESYP
                     ATGNQGILSLGCFSDEDITVEIRQSVGDSGAERAVFFGFLDPQELLEAVEAAGRAVTYE
                     LDRDSCKLTVESAGAEYLMLPVNADSGWHCTVNGEERAISRLAGNLMLVPLDEGTNEIT
                     LCYVPRGMKKGAAVTGMALMLLAGWGVLSRLLRRKSVLDKIYAGLGCAAADIFAVVYAG
                     FLLVVYVIPVVYTIYLRWI"
     CDS             12465..13949
                     /locus_tag="ctg8_8"
                     /transl_table=11
                     /translation="MEKLQARKKVYLWLLILLSLCALIPLAVLSKYNHQSGDDYGYAYR
                     TFQIWRETHSFWNVIKEAFATSAEFYQKWQGLYASAVLLALEPGIFGDKYYALTGILLL
                     AIIVGANCAGTVYIFHRKCGCPRLEGFAAGCVMSFLMIEWMPSALQGLYWYNGAMNYVF
                     FHAVLLLLLCVLLSLAGEHPRRKAGRTVLAVLLAVLLAGGNHVTAFMGILLIVGFGIFA
                     AVKKRRQNLICCVITLAAMVAGFLFNVTSPGTRIRQSYFSDRPGVAGTIVTAVKTGIAC
                     INSWMGLAVIVTAVLLLPVLLPLVKKIRGQYGFSFRYPLLVFVLSVAWLCAMFCPPIYA
                     MGTPGDVRLTNVVYFSFVWLFVLNEAYLCGWAVTRLEASGAAALSGAAGEFPGSFLITA
                     AVLAVGMIIGCGENMTAWQAYLLIRSGEAQEYSAEADERYAVLCDSAGEDVVLKAYTAK
                     PWMLFLDDITEEKSDWRNEYMRVYFGLNSVVLEQTE"
ORIGIN
        1 gaagatgcaa acatccggct ggttagaaat gccacatttt ttgaaccaaa tttccctctg
       61 tatctccatc tgaaatccca cggtgtgatc ttctgataat attacttatc acgaaaaggg
      121 gctgcacatt tgatgcgcag cccctttctc tgtatctgtc agcctgcagc ctgatccttc
      181 tgctccggtg cgttctgctt tgccagattt ttgtttgcgg tggagagcat cagcttgata
      241 cggttgagct ggtttacctc gctggcaccc ggatcgtaat cgatggccac gatattggaa
      301 ccaggatagc ggtgacgcag ttccttgatg acgcccttgc cgaccacatg gttcggcagg
      361 caggcgaacg gctgcgtgca gacgatgttc ggtgttccgg tgtggatcag ctctaacatc
      421 tcaccggtta agaaccagcc ctcgccggtc tggttgccct cggatacaat gtctcttgca
      481 tatctggcaa gatcatcgat gtgcgcaggt gcagtaaagt gcctgctctt tgtgaattca
      541 tctcttgcag cgctgcgcag ccactcaaag aaattgatgc ccagacggcc gatcttcttg
      601 gacttctggc tcatgccgag attgtctgct ttaaagcccg tattgtagaa gcagtagagc
      661 aggaaatcgg tcagatccgg tacaacggcc tctgcaccct cggattcgag aagctccacc
      721 agatgattgt tggcagccgg atggaacttg acaagaatct cgccgacaac gccgacgcgc
      781 ggtttcttga tgtctttgcg cggaaggttg tcaaaatcgc ggatgatctc gcggcacatt
      841 ttcttgaact tgccgtggga gagcatcttt ttctgggtaa taaaggcgat aacctctttt
      901 ttccatttct catgcaactc gtccgttgat ccggcaaccg cctcgtaagg gcgcgttgcg
      961 tagacgcagc gcatgaagat atcgccaaac tccagcgcgt agagtccgtg ctggatcagt
     1021 ggcagtgtca gcttaaagcc cgggttcttc tccagaccgc tcagattgat cgagatgacc
     1081 ggaacgtccg gatagccggc tttttccagt gcacgccgga tgaagccgat gtaattgctg
     1141 gcgcggcagc cgcctccggt ctgggagatt aagatcgcgg tgcgcgacat atcataatcg
     1201 ccggacatca cagcagccat cagctggccg accacgatca gggacgggta gcaggcgtcg
     1261 ttgttgacgt actttaagcc gacatccacg caggtgcggc tgtccacatc cgggacaaca
     1321 aggttgtacc cggccgtctg gaacgccggc tccaacagct caaaatggat cggcgacatc
     1381 tgcggacaga gaatggtgta gttcttgcgc atctcctccg tgaagacgac gcggttgtaa
     1441 tttgccggaa cgatggtgcg cttcgtctgt ttcttctcac ggacacggat cgccgagatc
     1501 agggaacgga tacggatgcg cgccgcaccg aggttgttga cctcatcgat ctttaagcag
     1561 gtgtagatct tgccggactt tgtcagaata tcgttgacag cgtctgtcgt gacggcgtcc
     1621 agaccgcagc cgaaggaatt cagctggatg aggtcgagat cgtctcttgt cttgacatag
     1681 ttcgccgcag cgtacagtct ggagtgatac atccactgat ccatgacgat gagcgggcgt
     1741 tccaccggct gtaagtggga gatggaatcc tccgtgagca cggcgatgcc gtaggaggta
     1801 atcagctccg gaatgccgtg gttgatctca gggtctacat ggtacggacg gcctgcgagg
     1861 acgataccgc gtcttccggt ctcctttaaa tactgtaaga cttcctcgcc ttttttctgc
     1921 atctccatcc ggcagacggc gagctccttc cagccttcgg caaccgcgtc gcggatctcg
     1981 gattccggaa tcccgaactc cgactggcca aaggtcttaa tcagctggga ggaaagcgtc
     2041 tcctcgctgg cgaaagacat aaacggattt aagaacttca cctgaccgga ggtgatctcg
     2101 tccacgttat ttttgatatt ttccgcgtag gaggtaacga tcggacagtt gtagtgattg
     2161 ttggaatccg ggaattcgtt gcgctcataa ggaatacacg ggtagaaaat aaaatcgacg
     2221 ttctggtgga tcagccatgt cacatgaccg tgtgccagct ttgccgggta gcactcggac
     2281 tcgctcggga tggaatcaat tccaagctcg tagatcttgc gcgtcgactg cggggagagt
     2341 accacggaaa aaccgagctt cttaaagaaa gttgcccaga acgggtagtt ctcgtacata
     2401 tttaaaacgc gcggaatacc gactgtgccg cgtgctgctt cctcggcgga aagcgggggg
     2461 tagtcaaaca ggcgcttgtt cttgtattcg tagaggtttg gaatgttgtc tttatttttc
     2521 tccttgccga ggccgcgctc acagcggttg ccggtgatat actggcggtt gccggaaaag
     2581 cggttgattg tgaggagaca gtggttggta catccctgac atcttgccag ctttgtgtcg
     2641 aaggtcagcg cattgatctg ttcgatggaa agcatggagg tctggtagcc tgcctcgtga
     2701 cgctctctgg cgatcagtgc ggcaccgaaa gcacccatga tgccggcaat atccggacgg
     2761 acacattcga cacccgcgat tttctcaaaa ctgcgcagta cggcatcgtt gtaaaacgta
     2821 ccgccctgta cgacgatatt tttcccgagc tggcttgcat cggaaagctt gattacctta
     2881 aataaagcat tcttgatgac agagtacgca agacccgcag aaatatctgc aacggatgcg
     2941 ccctctttct gcgcctgctt taccttggaa ttcataaata cggtgcagcg ggttccaaga
     3001 tcgatcggat ttttggcaaa aagagcctcc tttgcaaaat cctgtacaga gtagttgagg
     3061 gattttgcaa acgtctcgat gaaagaaccg cagccggagg aacaagcctc attgagctgt
     3121 acggaatcca ccgtctgatt cttgatcttg atacatttca tatcctgacc gccgatgtct
     3181 aagatacagt cgacttccgg gtcgaagaac gcggccgcat agaaatgagc caccgtctca
     3241 acctcgccgt catcgagcat caaagcggct tttaacagcg cttcgccgta tccggtggag
     3301 caggagtgga cgatctttgc cttcggtgga aggagcgtat agatctcctt gatggaacgg
     3361 attgccgttg caagcggact tccgttgttg ttgctgtaga aagaatacaa aagggaaccg
     3421 tcctcgccga ctaaggcaat cttggtcgtg gtggaacctg catcgatgcc cagatagcag
     3481 ttgccctcat aagtggagaa atctgcggat ctgacattgt gtccgtcgtg gcgcgcacgg
     3541 aaagcgtcgt actcttcctg gctggcaaac agaggatcca tacgggcaac ctcaaattcc
     3601 atcttgatgc cgtctgagag ccggtcgcgg agagagacga gcgtggtcgt ctcacccggc
     3661 ttgtaattta aagcggaacc gatcgcagca aacagatggg aattctccgg tgtgatggcg
     3721 tgttcgtcgt ccagattcaa ggtgcggata aaagcagcct tgagctcgga aagaaagtga
     3781 agcggacctc cgagaaaggc aacatgaccg cggatcggct taccgcaggc aagaccgctg
     3841 atcgtctgat tgaccactgc ctggaaaatg gaggcagaga gatcctctct ggtagcaccc
     3901 tcgttgatta acggctggat atcggtcttg gcaaagacac cgcagcgcgc agcgatcggg
     3961 tagatggcct tgtaattctt ggcgtattca ttcagaccgg tcgcatccgt ctggatgagg
     4021 gatgccatct ggtcgataaa agaaccggta ccgccggcac agatgccgtt catacgctgc
     4081 tcgacattgc cgccctcaaa atagatgatc ttggcatcct caccaccgag ctcgatggca
     4141 acatcggtct gcggtgcata atgctgcagg gcagtggaca cggcgatcac ttcctggaca
     4201 aacggaacac cgagatgctt ggcgagtgtc agaccgccgg aaccggtaat catcggtgca
     4261 acagcaaagt cgccgagtgc atcgtaagct ttctggagaa gggaggataa ggtctcctgg
     4321 atattggcaa aatggcgctc ataatcagag aagagcagat gatcctcctg gtctaaaatt
     4381 gcgaccttga cggttgtgga accgatgtcg attcccaatt tatgaagtgt attgttttcc
     4441 ataattccct ccatggctgt ttctcgtaaa gtaaatactt tagcagagta aaatatgtaa
     4501 aagatttctt cttattataa atagtgccaa tctggcgata aacactctac attatacgac
     4561 aggatatgtc aaaagacaat gtgcattttg ccggaaaagt ataaactttt tgtaaagaag
     4621 aatccctctg attgacaaag atttccccga ccgatatact gaacaacgta atgtcatttt
     4681 tggaaaggtc aggaacagag tgtatgaact ggttaaataa attagaacgt aaattcggca
     4741 actgggcggt tcccaatctg atcgtgtggc tgatcggagc ttacacgatc gggtttgtgc
     4801 tctaccaggt gaatccgtcg atcataggac ttttgatgtt gagtccgtat cacatcctgc
     4861 acggacaggt ctggcgcttg attacctggg tgtttatgcc cacagacacg aatctggtgt
     4921 atcttctcat tatggcgctt ttctattatc agcttggaac gacactggag cgcacatggg
     4981 gaaccttccg gtttaacgtc tatattttcg gaggtatgct gtttaccgtc atcggagcgt
     5041 ttctgctgta cggtatcatg tatctgatga acggcggtgt gacgacggag atgcttctca
     5101 tcggaacgag tttcagcaca agttacatca acatgtccat cttccttgcg tttgcatgta
     5161 tgtatccgga tatgcaggtt cttctgatgt tcattatccc gattaagatg aagtggatgg
     5221 cggctgtgta cggcgttctg attgctttaa gcttttttga gaccggatgg gcgggaagaa
     5281 tggcgatttt tatgtcgctc ctcaacttta ttattttctt cttctccacc agaaacctca
     5341 agcgctatac gccgcacgag gtgcacagac gccagaagtt taaggcagac atgcgaagac
     5401 cgcagggata tgcgggcggt gcgaagcaca agtgtgctgt ctgcggcagg acggaacttg
     5461 acgatccgac gctggaattc cgtttctgct ccaagtgcga gggcaattac gaatactgtc
     5521 aggatcatct gtttacacat cagcatattc ggatgagcta gaaagtatga aaaagaaaaa
     5581 ggtgatactt cgattccgcc agccggcgga gaagaagtat cacctttttc tttcttttag
     5641 gagtagaaat cttttagcgc atccatccgt gcactcatat tggaaaaaag tgcgtcgacg
     5701 atcgtgatgg ctgccatgga ttccaccacg acaacggcgc gcggaacgat gatcggatcg
     5761 tggcgtccct tgatgttgac cgagatctcc tccccggact gattgacagt gcgctgtgtg
     5821 gcggcgatgg aaggggtcgg cttgatggca gcccgaagga tgatgtcgct tccgtcgctc
     5881 atgccgccta agataccgcc ggcatggttg gttgctttgg caatcctgcc gtcctcaccg
     5941 aggacaaagg catcgttgtt gttcttgccg gtcgcttttg ctacgtcaaa tccgtccccg
     6001 atctcaaaac ctttgacggc accgatggac atgaccgcct tggcaaggtt cgcattaagc
     6061 ttctcgaaga ccggatctcc gatgccggcg ggcatcccct ttatgataca ctccacaatg
     6121 ccgccggagg aattcagttc cgccatgcag gcatccagat agttttcggc gttctcggct
     6181 gcctcggcgt ccggcatata gagcggattc ttcgtgactt cggaaaaatt aaaacgatcg
     6241 gaagatacgg cgatcgggcc gatggatttt gtgtaggtta taaaggtaat gccgagctcg
     6301 tttagaatct tgacggcgac ggcgccggcg gcgacacgcc cgatggtttc tcgcccggag
     6361 gagcgcccgc ccccgcggta gtcgcggaag ccgtatttct ggtcgaacgt gtaatcggcg
     6421 tgaccgggac ggtaatagga ggcaatctcg ctgtagtctt tggactgctg gttgcggttg
     6481 aagacgacaa gcgagatcgg ggtgccggtc gtctttcctt caaacacgcc ggagagaatc
     6541 tctacggcgt cgtcctcttt gcgcggcgtt gcatatctgg actgaccggg cttgcgccgg
     6601 tcgagaaact tctggatatc cgcctcacag agagaaagtc ccgccggaca gccgtcgatg
     6661 acgacgccga cgccctttcc gtgagattcc ccccaggttg tgattttaaa aagagttccc
     6721 aaagtagacc ctgccatgtg attccctcct gcttacataa tgatctttct cgattataaa
     6781 agatttgact ttgcgccgca acagaaatat gttatgattt gacggagcag aagtaccagc
     6841 aggcgaggag aagaatattt catgatagag aaataccttg tgaaaaagat aacagagccg
     6901 gtggactgga aggtaaccgt gccgggatcg aagagcatga cgaaccgcgc gcttcttatg
     6961 gcagtgctgt ccgcagggac ggtgcgcgtg gaaggagtct tgttttccga tgattccaga
     7021 cactttctgg cgtgtcttgt ggcgctcggc tttacagtgg agatagagga agaaaaaaag
     7081 tgcgtgaccg tgacgggctg cggcggcagg attccccgcg gggaggcggt aatcgacgtc
     7141 ggaagcgccg ggacagcggc gcgttttctt gcggcgatgc tcggattttc ggacgggtgc
     7201 tatgagatcc gctgctcagc gcagatgaaa cggcggccga tggcggagct gttcgatctg
     7261 ctttctggtg cgggagcgaa gattatattc ctcgaggagg aagggcatct tccggtgcgc
     7321 atcacaggat gcagatacgc ccgggcggat aagacggcag gggagacgcc gcgggagttc
     7381 tctcttgaca ttacgaagag cacacagttt ttaagcgcgc tgctgttgat tgcgccgatg
     7441 gttccggaag ggatgaagat ccacatcacc agtgagaaga cggacggctc atacatccgc
     7501 atcacgcgga agatgatgca ggaattcggc gtgagtgtcg cttttgacgg aagagactac
     7561 gaggtgccgt gcagaagttc ctaccggaaa gagacttata tggtggaacc ggatatgtcg
     7621 gctgcctgct atttttatgc ggctgcggct gtgaccggcg gacgggcgct tgtgcggcat
     7681 gtgcatatgg acaacacaca gggagatctg cgtttcctgg aagtgttgga gcacatggga
     7741 tgtaccgcgg acgatacgcc ggagggcgtc ctggtaacgg gaccggcgga cggtgcgcta
     7801 cggggcatca cagtcaatat gaacgatttt tccgatcagg cgctgaccct ggcggcgatc
     7861 gcgccgtttg ccgacgcgcc ggtgcgcata gagggaatcg gacatatccg tgggcaggaa
     7921 tgcgaccgga ttcacgcgat acagacgaac ctgacagcgc ttggcatccg gtgtgaggag
     7981 aaagaaacgg ctgccacgat ctatcccggc agcccccacg gcggaagcgt ggagacatac
     8041 gacgatcacc gcgtggcgat ggcattttcc ctggtcggac ttagaaccga cgggattgtc
     8101 attgagaacc cggcgtgctg ccgcaagacg tttgaaaatt attttaccgt gttaaacgaa
     8161 ctgactggga aaacggtgga aagctgacaa gatgccggac tgcacaaggc tggtggaagt
     8221 gaaagcggaa aaagcgcaga accagagaaa ataaagaaga actacaggca ataaaaggag
     8281 acgaaaaaca gatgtatgaa ttattaaaac aggaaggacg cgcgaagaga ggcgttttcc
     8341 atacggtgca cggagatatc cagacgccgg tatttatgaa tgtgggtacg gtggctgcca
     8401 tcaagggagc tgtctccacg gaagatttag agcagatcaa atgtcaggtg gagctgtcaa
     8461 acacctacca tctgcatgtg cgcaccggag acaagctgat caaggaagtg ggaggactgc
     8521 acaagtttat gtcgtggaat cgtccgattc ttacggattc cggcggattt caggtgttct
     8581 ccctggctgg gctccgcaag atcaaggagg agggcgtcta tttccactcg catattgacg
     8641 gggcaaagat tttcatggga ccggaggaga gcatgcagat ccagtccaat ctcggttcca
     8701 ccatcgccat ggcattcgat gaatgtccgc cggcgcttgc cgagcggaaa tatgtggagg
     8761 attccgtggc acggacgacg cgctggctgg agcgctgcaa gaatgagatg cagcgactca
     8821 acgggctgga ggatactgtg aaccgtcacc agatgctgtt cggcatcaac cagggagcca
     8881 tctacacgga catccggatc gaccatgcaa agcggatttc cgagctagat ctggacggct
     8941 atgcggtcgg cggacttgcg gtcggcgaga cacatgagga gatgtaccat gtgctggatg
     9001 agaccgtgcc gtatcttccg gtgaacaagc cgacctatct catgggagtc ggaacgccgg
     9061 ccaatattct ggagggagtg gagcgcggca ttgacttttt tgactgtgtt tatccgtccc
     9121 gcaacggccg ccacggtcat gtatacacga atcagggcaa gatcaacctg ttcaaccaga
     9181 agtacgagaa agatatgcgc ccgatcgagg agggctgcgg gtgcccgacc tgccgccgct
     9241 acagcagagc ctatatccgc catctgctca aggcaaaaga gatgcttggc atgcgcttat
     9301 gtgttctgca caatctgtac ttctacaaca cgatgatgga agagatccgg gatgcgctgg
     9361 atgccggaaa ttttgcctcc tacaaggaag aaaagttata cggcatggga cagatcaacc
     9421 gggaaaagga aatggcaaag taaaagtaaa agtaaagggg aaaaggcttg ccaaacggcg
     9481 aggttttgtg tacaatattt tctaatgggg tcagacgact tcggacaagt ttatgatttt
     9541 aggaggatat cagatgtttt caatcttagc aacagagagc gcgtcatccg caggctggat
     9601 cagcatggtg gtatggctgg ttattttatt tgcatttatg tatttcttca tggtgcgtcc
     9661 gcagaagaaa gagcagcaga agaagaactc catgcttgca gagctggcag ttggagatac
     9721 ggtcttaacg acaagcggtt tttacggaac cgtgatcgac atcacagacg atacggtgat
     9781 cgtggagttc ggaagcaaca agaactgccg catcccgatg cagaaggcgg ccatctccgc
     9841 agttgagaag ccggaagatg taactgaata agaagatttt taagagggat agtatataaa
     9901 atgtattatc ccttttcttt ttgagagagt atttcggaga gcgaggagag attgtccgga
     9961 tgaaaagtaa aaaaaatacg tttgtttcac gtgccgccgt cggctgcgtg acaactgcca
    10021 tttttctgct gttgtgcatc ataaagggca tctatccgtt tggaattgcc acgcttgaca
    10081 ctgtggattt tcagtcccag tggattccgg catattacca tgtatgggat gtgctgcacg
    10141 gagacggcag cgcctttttt gactggagag tcggcggcgg gaataatttt gcgggagtga
    10201 gcgcgcagtt ttctctgttc agcccgttta acctgttctt cctctttgtg aaaagaagct
    10261 ggattgaaaa atccatgatc gtgtttcttt taatcaagct gcttgccatg ggctatggca
    10321 tgcgctggtt tttaaaagag cagatcctta aggaagagcg ttacggaatc tacattctgg
    10381 cgggaagcgt ggggtatgcc gtaaacggct atacgctttt gtactatggc atgggctggc
    10441 tggatgtggc agcgatcctg ccgctattgt gttatttctt ctgcaggatg gcggagcggg
    10501 aaggggactg gtgtctcggg aaaaatacgc tcggctatat cgtctgcctg acgctggtat
    10561 tcctcatcaa tattccgcag gcgtacatga tgtgtttttt cctgatcgtg tttgcggggg
    10621 gatatttttt tctgaaacga caggaccagc cgctaaaaaa gaacggcatt ttaaaattcg
    10681 ggctgacttc tttactgtcg cttggaattg cggcggtaat atttctgccg gcagcgaggg
    10741 caatgcttgg ttcctaccgg ctgtcgggcg aggagtaccg gggaatctcc ggctattttc
    10801 tgctgcttcg gcaggacgga atggacgcgg tgtggaaatg ggtgattctt ggcagcgtgg
    10861 cggttccgct gctgttcttc gtcatttctg gcagacggaa gcgggagcac atctggcagt
    10921 ggtatctggt ggcggcgatg gtgctgccgg ttttcttcga ggcggtcaat ctcatctggc
    10981 accgcgggac gtatgtgtgc ttcccgatgc gatatggtta tatgctggtg tttgccgtga
    11041 tttgtatggc agcggcgcgc gtgccggatt ttgtgggaga tagccgcgtg cggcggaaca
    11101 ttttatatgc gttcctggga atctggtgcg tgcagatggt ggcgcttggc atttctttga
    11161 tacagccgga aacgcacacg gacgagacgg attttgttgg ggatgccacg gaaatcggtc
    11221 ggccgcttgc gggaaaaacc gatgttttcc acaaggcaaa gctggcggac ggagcgattg
    11281 acaacaacta tccgctgatc gcagagagca cctcctactc caattatctg catctgatga
    11341 cgtcggagca gatcaggatg aacacactgc tcgggtattc tcaggtgtgg accagattaa
    11401 gtgacacggg cggaacgctc gcgtccgaca tcatgctggg gtaccgttat tatgtggcgt
    11461 ctaaggcggg atcgtgggga aaagacacgg cggcggattc cctttggccg cttgctgaga
    11521 ccgaaaagtt tacgctgtgg gaaaatgcgc ccgtcgggga cagggcattt tttatcacaa
    11581 aagcggacta tgaagcgtat gcagtcacgg aagcgtacac ggaaaatgtg tttgagaacc
    11641 agaaccggct gtcggagctg ctttttcaca cagttcccat tgactggaaa aaagagacct
    11701 atctggatga tcagaccgga gcggaattat cgtgccggtt ttacgcggat ggaaagcaga
    11761 tcttatatct ctatggaaag gatctgcagc aggcagaaat tacggtaaac ggggagagga
    11821 tctacgtccc ggattacaat gatctgtaca atgagagcta cccggcaacc ggcaatcagg
    11881 gaatcctctc cctcgggtgt ttttcggacg aagacatcac ggtggaaatc cgccagtctg
    11941 ttggggacag cggcgcagag agagcggtgt tcttcggatt cctcgatccg caggaactgc
    12001 tggaggcggt ggaagcagcg ggaagggcgg ttacatatga actggatcgg gattcctgta
    12061 agcttaccgt ggaatcggcg ggagcggagt atctgatgct tccggtcaat gcggatagcg
    12121 gatggcattg tacggtaaac ggagaggagc gggccataag ccggctcgcg ggcaatctga
    12181 tgctcgtgcc gcttgacgag ggtacgaatg agattacgct ttgttatgtg ccgcggggaa
    12241 tgaaaaaggg cgcggcggtg acgggcatgg cactgatgct tctggctggc tggggcgttt
    12301 tatcacgtct gcttcggaga aaaagtgtcc tggataaaat ctacgccgga cttggctgtg
    12361 ccgccgcaga tatttttgcg gtggtctatg ccggatttct gctggtcgtc tatgtgattc
    12421 cggtggtgta tacgatatat ttaagatgga tctgaggtaa cagaatggaa aaattacaag
    12481 cgagaaaaaa agtatatttg tggctgctga ttttattgag cctttgcgcg ctgatcccgt
    12541 tagccgtact ctcgaagtac aatcatcagt cgggggatga ctatggttat gcctaccgca
    12601 ccttccagat ctggcgggag acacattctt tctggaatgt gataaaagaa gcgtttgcca
    12661 catcagcgga gttctatcag aagtggcagg ggctttatgc atcggcggtt ctgctggcgc
    12721 tggaaccggg aattttcggc gacaaatatt acgcgctgac cggaatcttg ctgctcgcaa
    12781 ttattgtggg ggcaaactgc gcgggtacgg tttatatctt tcaccgcaaa tgcggctgcc
    12841 cgagactgga gggatttgct gccggctgtg tcatgtcgtt tcttatgatc gaatggatgc
    12901 cctccgccct gcagggattg tactggtata acggcgcgat gaattatgta ttcttccatg
    12961 cggtgctatt attgttgttg tgtgtgctgc tcagccttgc cggggagcac ccgcggagaa
    13021 aagcaggcag gacggtgctt gcggtattgc ttgcggtgct gcttgccggc gggaatcacg
    13081 tgaccgcatt tatggggata ctgctgattg tcggatttgg aatatttgct gcggtaaaaa
    13141 agcggcggca gaacctgatc tgctgcgtca taacgcttgc ggctatggtg gcgggattcc
    13201 tttttaatgt gacgtcgccg ggcaccagaa tccggcagtc gtatttttcc gacagacccg
    13261 gtgtggcggg aacgattgtt accgcggtaa aaaccggaat tgcatgcatc aacagctgga
    13321 tgggacttgc agtcattgtc acggcggtcc tgctgcttcc ggtgcttctt cccctggtaa
    13381 agaagatacg cggacagtat ggattttcgt tccgctatcc gctgcttgtc tttgtgttgt
    13441 cggtcgcctg gctgtgcgca atgttctgtc cgcccatcta cgcgatggga acgccggggg
    13501 acgtccggct gaccaacgtg gtatattttt ccttcgtctg gctgtttgtg ttaaatgaag
    13561 cctatctgtg cggatgggcg gtcacaagac tggaggcgtc cggggcggca gcactgtccg
    13621 gggctgcagg agaatttccg ggcagttttt tgatcacggc tgctgtactt gcggtgggaa
    13681 tgataatcgg atgcggggaa aatatgaccg catggcaggc atacctgctg atccgcagcg
    13741 gcgaggcaca ggaatattcg gcggaggctg atgagcgcta cgccgttttg tgtgattctg
    13801 cgggggaaga cgtggtgtta aaggcgtata ccgcaaagcc gtggatgctt ttccttgacg
    13861 atattacaga ggagaaaagc gactggagaa atgaatatat gcgcgtctat tttggactga
    13921 acagcgttgt gttagagcag acggaatgag acggcagaag ggagcagcgg acacaaaagg
    13981 caggctgctc ctttttcata agacccggtt atagggagta tgaaaaagaa aaatggattc
    14041 agaggttgca ttgtttcccg agatacatta ttatagaatt tatatactgt ctgttagtaa
    14101 tgtactaaag tcaatacaag acggattcct gcatggcagg aagaaaagag ggattagaga
    14161 gatggaatat aaggtaggcg tgatttccgg cgacgggatc ggaccggaga tcgtaacaga
    14221 ggcaaagaaa gttctggatc agattggaaa gacctacgga catgtgttcc gctatgaaga
    14281 gattctgatg ggaggctgct ccattgacgc gacgggtgag ccgctcacgg atgcggcgat
    14341 cgcttccgcg aaggcttccg atgcggtgct gatgggatcg atcggcggca acacatcgac
    14401 ttcgccgtgg tatcagctgc cgccggagaa gagaccggag gc
//
