LOCUS       c00035_gnlPro..        16465 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LBFBKAEH_35.
ACCESSION   c00035_gnlPro..
VERSION     c00035_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 22:40:37
            Original ID  :: gnl|Prokka|LBFBKAEH_35
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16465
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16465
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3000:6465]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3001..6465
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..16465
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16465
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(151..1290)
                     /locus_tag="ctg35_1"
                     /transl_table=11
                     /translation="MKSVKLASILFYLNSVFVVSCFVSCGSSPTEASFLLTADIRGGMD
                     KPGLLGLGDEIKGVTFVPLEVTTDDASLIDGVYDYAVTDRYIYVLPVKEPRIVLFDRQG
                     RFIRTLVKEGQGPGEFSGILPCIQVDERNDRLFLFSNNRVWEYTLEGEFIGQSTHEYSV
                     IYMRHIGKDRFAAISFPFQPFNGGGFGLGLFSRKGDTIAIKNDFYSFLLPHEKSGFTTS
                     IAPAYSDAQNSVLFKTGSNDTVFSISADRISATCVLDLKNSDAEVIRSLDVTDMSNLRI
                     EKKDPKDIFVQDMIEFPEHYYFRLLYNQGYYIASVDKKTGKTLVEKCEMPGSIYELADA
                     NLQHGMQGTRSYRNFPVWGRVIKDELVQVVTPYELNLYN"
     CDS             complement(1400..2878)
                     /locus_tag="ctg35_2"
                     /transl_table=11
                     /translation="MGEVRACAPTHEIMRKEKAFLMNNLYTFAYMRKDLNGAWHFSIGI
                     KFTILLFTIAILVLVLFSYRSDKHGNLFWQVEKLIPHHPDSALVLLEKVTDINGLSLRE
                     KARYCLLWTESRDEAGLRHTSDSIISIATDYYRTTRGCYWPPKAWFYRGKVYEDMDQPS
                     LALECYLRALEYEGGNWDYEFWGRLYNQIGRLYAEQELYGKAMSFLRKASAQYQLLNDT
                     AGQGRILEEVKKYEALRDSIGSLSARESIYQITSRYDVRPVREDLYRKELMLSQRGQER
                     YLYAFIIGIILFICFLLYRRWRNTQENALRREEALRRSIASQQQRMREEKEENERQIAL
                     LEKRITKIKEEKDQELMLVSLQLEKQRLEICNESIHNKESKHLLSVAILRKSEVYEKFH
                     DRDAGKIVSEDWELLEVLLNKAYDDFTLRLKKLYPAISDTELKVCMLTKIGVPANQITR
                     VLKYNSSVLRPRLFRKIFKKEGSTETFVEFISSF"
     CDS             3001..3693
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_3"
                     /sec_met_domain="SucD_FumR (E-value: 6.9e-75, bitscore:
                     240.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLLNSSIGKKLIMSISGLFLVLFLLFHLSMNVAAVFSGEAYNMV
                     CSLLGSNWYAVAATLVLAAGVVIHFVYAIILTLQNRKARGNDRYAINARPKGVEWASQN
                     MFVLGLIVILFMLLHFSQFWYKMMFAELIGHHEVALGTAMVSPQDGAAFINYYFQGNAV
                     ITVLYLIWYVALWFHLTHGFWSAIQTIGWNNTIWMNRWECISKIVATVICGLFAIITII
                     FFLNGVGA"
     CDS             3742..5685
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 197.2; E-value:
                     1.7e-60)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_4"
                     /sec_met_domain="FAD_binding_2 (E-value: 3.6e-61, bitscore:
                     197.2, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 9.3e-39,
                     bitscore: 122.2, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEINSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDVIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERYAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVHGDYQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNNTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFNEAEKNIQARINKLMSIKGKESVDSIHKRLGHI
                     MWEHIGMARNAESLKEAIQMLKDLKKEFWSNVFIPGNADDLNVELEKALRLADFIEIGT
                     LMAHDALDRAESCGGHFREEHQTEEGEALRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     EFVVPQTRNYKK"
     CDS             5710..6465
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_5"
                     /sec_met_domain="Fer2_3 (E-value: 8.2e-26, bitscore: 80.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 2.9e-12, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.1e-06, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDINITLKVWRQKGPNVKGQFETYQLKNINQGTSFLEMLDILN
                     EQLISEGKEPVVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFTSVNTGGVPDANAIPIPKPDAEMAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFICAKLQD"
     CDS             6888..8099
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg35_6"
                     /sec_met_domain="Radical_SAM (E-value: 1.2e-16, bitscore:
                     51.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKRTTSSFRAMSTERKLESIFLFVTGRCNAKCAMCFYAQEMDK
                     KQPDLTFDEIKKISETAGQFNRLWISGGEPTLREDLPEILELFYKNNHIKDVNIPTNGL
                     KPDRIVEWVKRFRQNCPDCNINVSLSLDGFGTTHDTQRGVPGNFYKALETLRKIQENFG
                     DDGKVLKNIATVITKYNIDQVEDFMTWVYGRFRTSTHTIEAARGMTRDDGVKILTESTL
                     RKIQDDISPIYSAYADRMVADTTGLRKPITRFFYLGLIRTLYNIRASNIDHPTPWGMDC
                     TAGETTLVIDYDGRFRACELREPLGNIKEYGCDISKVMNSEAMKQEIAAIGHGYKANCW
                     CTHGCWITSSVIFNPRKMIRSVYKGYRETKRLNHPLAINEQKLQTMEAKYHLDIERLRQ
                     LNIR"
     CDS             8133..9365
                     /locus_tag="ctg35_7"
                     /transl_table=11
                     /translation="MKILLVTRGSQGDVLPYLAIAAELERRGHEVTINLPQIFEETVKP
                     YGFKYVLQQFDDIGGMIDSAAQNSHKFRPFLKWMRNVIDKQFDQLIPLLKEHDILVSTN
                     SEFAVASIAEYCKKPLIRTAYAPFLPGKKIPPAVLPFPKPNPIITPAILWKLMNRMTNF
                     MVKDTINKNRAKYGLAPIRNFGYHAGERSYNYLLFSQHLGNVDPDWTFEWSIGGYCFND
                     TFQYDEKAYEEMISFVDSAQSPIIFFTLGSCSSKDGNRFSKALVDICKKHDYRLIIGSG
                     WAKTGITLQADKHLFLMKQPVPHNLIFPHCDGVIHHGGCGTTHSVGRAGKPQLITPLII
                     DQPYWSYRIHQLGLGPEGVKIAKASEQEIERKVCDLVTNPLYKKNAAHIGEMIQKEGGI
                     KNICDSIERFQ"
     CDS             complement(9571..12708)
                     /locus_tag="ctg35_8"
                     /transl_table=11
                     /translation="MIRNIINLKAIILYFGLILCLIAGMPTPAYGSFSYPVKDESYVLV
                     INSYVDGERWSGNLLNIISKFATPEEYTLRIDHMSVMLVDTPEKLKEKQEAFFEVNKKK
                     PDGIIYLGVNGWAFMRDKIREKWGDIPTLVCSETGEMAEDECYFNQRHSSDRVIPLQEA
                     VKGYNATGLVIPYYVKGSIDLVKELIPGLKRLIFISDRRYVSTWLRDEMEKHMETSFPE
                     GKVDFYTEGSCSMDSLMAVLSEKDPHRATAVMYYSWITEKPFLNHSLLYSTLYQGINGI
                     SRHPVFSLYDMGVEEGYTIGGYYNSAKTIETALIPLLQQVYNGEDMGKIPVSTVNDPHK
                     YLNYASLISAISNEDNFPRDAIYLNAPPSFLEKYWMQLLGFLIFFLVVVFLAGYYVYRS
                     KQKMKEVELRLLSRYRDLFNNMPLPYIRQRLIREGTQIDVQVLDVNHAFEEKIAPKDFV
                     VNKRGKEIANLIGGSYPLLLSAVPTVLESGKSFTYEYYFEPTGLYYTIIIMPTSEENVV
                     DAFFIDITDIHKFQTHLKAMNHKLAMALEAADLLPWRYNLAEGKIIYESKVHPEDNIET
                     AEIHTHEVSLEEYFSKIHPSFRACVEKAFDDLCNGKIKKVRKEYCLERLIPGEDRHEWE
                     EIQVMAEYDASGKPKALIGSTISITERKQLEHDLRMARDKAEESNKLKSAFLANMSHEI
                     RTPLNAIVGFSNILASTDNLEDKKEFADIIENNNSLLLQLINDILDLSKIEAGTLEFTY
                     DYVDINAVLRDLEQSAHLKNKNPDVQISFKDYLEPCVIYTDRNRLSQLMINLLNNAMKF
                     TQAGSISFGYKLRDDNTLWFYVEDTGCGIPENKRKDIFGRFVKLNTFAQGTGLGLSICE
                     MIVTQMKGTIGVDSVEGKGSRFWFTLPFQPKKELLPNEEQKPVTLEKIARSEVTILIAE
                     DNSSNYRLFESILKPEYKLIHAWNGKEAVELFHQHKPQLILMDIKMPVMDGYEATAEIR
                     KVSASVPIIAVTAYAFAQDEQRIIKSGFDAYTAKPINGKVLKDKISTLLTHRIILM"
     CDS             12939..13715
                     /locus_tag="ctg35_9"
                     /transl_table=11
                     /translation="MELMDMKDYDIDFKEKRTNGYLIATLFIIVGILFLLRNLGMIDPS
                     LFDLLVSWPMLLVVSGIFMIFHRNPVGGMLLVGVGVYFLFPQLNWITNDFLRVYWPLGL
                     ILLGLVIMLKRKDSIRTKKHKRPFNHPPFGHRKPNDEINYETDNGFVSVDTTFNSVRHI
                     VLDPVFKGADIDVSFGNVILDLKKTTLEADETIINIDSSFSGVVIYVPKGWLVRLKVDS
                     FLAGCQDMRDLTETTDMTHTLYICGDLSFSGLELRD"
     CDS             13723..14517
                     /locus_tag="ctg35_10"
                     /transl_table=11
                     /translation="MQEHPITTSILHKGLGSLLLLLAIAIQCALLTLYGDLPLSITLVD
                     SLLSIALFAVAGYYLWYVQCTLHIMQARVAFAVLVQIACIAGCSILLQIFGLEDWEEFS
                     ITIPFRFLFGLMAWIILSQWYASRERKSEVELIVRQMEEKTAPPPTTVPEEILDRISVK
                     DGTRIHIIPIKEIFYLQACGDYVTLFTTSGQHVKEQTMKYFERSLPSPEFVRIHRSYIV
                     NTEQILRVELFGKETYQVRLKDGTYLRASSAGYKLLKERLSL"
     CDS             complement(14857..15381)
                     /locus_tag="ctg35_11"
                     /transl_table=11
                     /translation="MKKYWHIALMLFCVLMITSCGDDDEALEVDEVWKIQNEEAFQAQM
                     LVPGFEQLSSQSNAGFILYKVLKTGESKEPIYYTSKVECYYKGSFINGEVFDDRSFEAG
                     EPAVMEVYKMTDGFATALQNMHPGDKWEIWVPSQLGYGEAGYKNPNTGAVVVKPCTTMI
                     FEMEVVGIVEE"
ORIGIN
        1 ccttgtaatg gctgaagcgt tggaaaaatg ggacgaagta tgtggatagt ctgcataact
       61 tctgttaggc atgtgttaac agtcaatgga tatgggggaa gacagacaaa ggaaaatgag
      121 aaaagttggt gttttaaggg gtgggaaact ttagttatat aagtttagct catacggggt
      181 cactacttgt accagctcat cttttatgac cctcccccag accgggaaat tccgataact
      241 tctcgtaccc tgcatgccat gttgaaggtt cgcatccgcc agttcataga tagaacccgg
      301 catctcacat ttttccacaa gtgtctttcc cgtcttttta tctacagagg ctatataata
      361 gccttggtta tacaataaac ggaaataata atgttccgga aactcaatca tatcttgcac
      421 aaagatatcc ttgggatcct ttttttcaat tcgcaaatta ctcatgtccg taacatccaa
      481 cgaacgaatc acttccgcat ccgagttttt cagatcaagg acacaagtcg cacttattcg
      541 atccgccgag atactgaaga ccgtatcatt gctaccggtc ttaaacaaca cggagttttg
      601 cgcatcagaa taagcggggg cgatacttgt cgtgaacccg ctcttctcat gaggtaataa
      661 aaaggaataa aaatcattct tgatcgctat cgtatcccct ttcctcgaaa ataggcctaa
      721 tccgaatccc cctccgttga aaggctgaaa agggaatgat atggcggcga aacgatcctt
      781 tccgatatga cgcatataga ttaccgaata ctcatgggtg gattgtccga taaattcacc
      841 ttccaacgta tattcccaaa ctcgattatt actaaataaa aaaaggcggt cattacgttc
      901 gtccacttgg atacatggca gaataccgct aaattcaccc ggcccctgcc cttcttttac
      961 caacgtccgg ataaaacgcc cttgccgatc gaacaggacg atacggggct cttttacggg
     1021 aagcacatag atatatcgat ctgtcacggc ataatcataa actccgtcta tcaacgaggc
     1081 atcatccgtg gtcacctcta aagggacaaa agtaaccccc ttgatctcat cgcctaaccc
     1141 caatagaccc ggtttatcca tccctcctct tatatccgca gttaaaagaa aggacgcttc
     1201 cgttggcgaa gaaccgcatg acacgaaaca agaaacgaca aaaacactat ttaaataaaa
     1261 caagatagag gctaacttta cacttttcat aaccatgctt ttttgcctcc aaaaatatcc
     1321 cgcatatctc acaaatcaca tgataaatga gaacaaaaat gagaacaaac ctgccaatac
     1381 cgctataaat acataataat caaaaacttg agataaactc cacaaatgtc tccgtagaac
     1441 cttctttctt aaaaatcttc cggaatagac gaggacgaag taccgaacta ttatatttca
     1501 atacccgtgt gatctggttg gcgggaacgc cgatcttcgt aagcatacag accttcaact
     1561 ccgtatcgga aatagcagga tatagttttt tcagccgtaa ggtaaagtca tcataagcct
     1621 tattcaacag cacctccaaa agctcccaat cctcagagac aatcttgccg gcatcccgat
     1681 cgtgaaactt ctcatagacc tccgatttcc gcaagatcgc aacagataat aaatgcttac
     1741 tctccttatt atgaatcgac tcgttacaaa tctccagccg ttgtttttcc aattgtaagg
     1801 aaaccaacat caactcttga tccttttctt cctttatttt cgtaattctc ttttccaaaa
     1861 gggcgatttg ccgttcattc tcttcttttt cttctcgcat acgttgttgc tggctagcaa
     1921 tcgagcgtcg caaggcttct tcccttcgaa gagcgttttc ctgcgtattt ctccatcgcc
     1981 gataaaggag gaagcaaata aatagaatta tgccgataat aaacgcgtac agataacgct
     2041 cctgtcccct ttgcgatagc atcaattctt tcctatacaa gtcctcacga accggcctta
     2101 catcataccg ggaagtgatc tgataaatcg attctctcgc tgacagcgat ccgatagaat
     2161 cccgtaacgc ctcgtatttc ttgacttcct ccagtatccg gccttgtccg gccgtatcat
     2221 tcaagagctg atattgggca ctcgcttttc tcaaaaaaga catagccttg ccatataatt
     2281 cctgctcggc gtacagcctc cctatctggt tatataaccg tccccaaaat tcgtaatccc
     2341 aattccctcc ctcatattcc aacgcacgta aatagcattc caaagctagg gacggttgat
     2401 ccatatcctc atagactttc ccccggtaaa accacgcttt gggaggccag taacagcctc
     2461 gtgtcgtcct ataataatcc gtagcgatag agattatgga atccgatgta tgcctcaatc
     2521 ccgcctcatc ccgtgattcg gtccataaca gacaataacg ggctttctct cgaagcgata
     2581 atccattgat atccgtcact ttctctaata acaccaaagc gctgtccgga tgatgcggaa
     2641 tcaatttctc tacctgccag aacaggttgc catgcttgtc gctcctatac gaaaaaagca
     2701 caagaaccaa gatcgcgatc gtaaacaata agatcgtaaa cttgatccct atagaaaaat
     2761 gccatgcccc attcaaatcc ttacgcatat aggcaaatgt atataaatta ttcataagga
     2821 aagccttttc cttccgcatt atttcatgtg tcggggcaca tgccctgacc tctcccatta
     2881 atgcagaaat atttctttaa tcgtttgcgc gatatatgga tttagcatac ctttgcgtga
     2941 taattacata gtttaagtag aaatttctaa atacaattaa ataacttaaa ttattatctt
     3001 atgtggttac ttaattcttc tatcgggaag aagctgataa tgagtatatc aggcctcttt
     3061 cttgttctgt tcttattgtt ccacctgtcg atgaacgtgg cggccgtttt ctccggagag
     3121 gcttataaca tggtttgttc gctgttgggc tctaattggt acgctgtggc agctactctc
     3181 gtattggccg caggcgttgt gatccacttc gtgtacgcta tcattcttac cttgcaaaac
     3241 cgtaaggcac gtggtaacga ccgttacgct atcaacgctc gtccgaaagg cgtggaatgg
     3301 gcatctcaga acatgttcgt tttgggtttg atcgttatct tgttcatgct gttgcacttc
     3361 agccagttct ggtataagat gatgttcgcc gagctgatag gtcatcatga ggtagcgctg
     3421 ggaacggcta tggtatctcc gcaagatgga gccgctttta tcaactatta cttccaaggt
     3481 aatgccgtga tcaccgttct ttatttgatc tggtacgtgg ctttgtggtt ccacttgact
     3541 cacggtttct ggagcgctat ccaaacaatc ggttggaata acacgatctg gatgaaccgt
     3601 tgggaatgta tctctaagat cgtagctacg gttatttgcg gacttttcgc gatcattact
     3661 atcatcttct tcctaaacgg agtaggtgct taattgcaag ctacaggttt tataattaag
     3721 aacttttgaa attaaatcat tatgtctgaa ataaattcta aaatacctca aggcccgttg
     3781 gctgagaagt ggactaatta taaaaatcac cagaaattgg tgaaccccgc taacaagcgt
     3841 cgtttggatg ttatcgtagt cggtacaggt ttggctggag cttccgctgc cgcatctttg
     3901 gcagagatgg gattcaacgt attgaacttc tgtatccaag attctccccg ccgtgcgcac
     3961 tctatcgccg ctcaaggtgg tatcaacgcc gctaagaact accagaatga tggtgactct
     4021 gtttaccgtt tgttctacga tacgatcaaa ggtggtgact accgtgctcg tgaggctaac
     4081 gtttatcgtt tggctgaggt ttctaactca atcatcgacc agtgcgtggc tcaaggcgtt
     4141 cctttcgctc gcgaatatgg tggtttgttg gataaccgtt cattcggtgg cgctcaggta
     4201 tcgcgtacgt tctacgcccg tggccagacg ggtcagcagc ttttgttagg cgcttattca
     4261 gcgttgagcc gtcagatcgg tttgggtaag gttaagatgt acactcgtca tgagatgttg
     4321 gatgtagtta aggtagacgg tcgtgctcgt ggtatcatcg cccgcaactt gattacaggt
     4381 aagatcgagc gttacgccgc tcacgctgta gttgtagcta cgggtggtta cgttaatacg
     4441 ttcttcttgt caaccaacgc tatggcatct aacggttccg ccgcatggca atgctacaag
     4501 aaaggcgctt acttcgctaa tccttgtatg gttcagatcc acccgacttg cgttccggta
     4561 cacggtgatt atcagtctaa attgactttg atgtccgagt ctttgcgtaa tgatggtcgt
     4621 atctgggttc cgaagaaact ggaagacgct aaggctttac aggcaggaac aaagaaaggt
     4681 aaagatatac ctgaggcaga tcgcgattat tatttggagc gtcgttatcc ggcattcgga
     4741 aacttggttc ctcgcgacgt ggcttctcgt gccgctaaag agcgttgcga cgctggcttc
     4801 ggtgttaata acacaggttt ggctgtattc ttggacttct ccgacgctat caaccgtctg
     4861 ggtaaagagg ttgtaaaaca gaaatatggt aacttgttcg atatgtacga agaaatcacc
     4921 aacgacgatc catacgaaac tccgatgatg atctacccgg cattgcacta ttcaatgggt
     4981 ggtctgtggg ttgattatga attgatgact tctatcccgg gtctgttcgc tatcggtgag
     5041 gcaaacttct ccgatcacgg cgcaaaccgt ttgggtgctt ccgcattgat gcaaggtttg
     5101 gccgatggtt acttcgtatt accttataca atccagaact acttgtcaga ccagattcag
     5161 gttccacgtt tcagcaccga tctgcctgag ttcaacgagg cagagaagaa tatccaagcc
     5221 cgtatcaata aattgatgag catcaagggt aaagagtctg ttgattctat ccacaaacgt
     5281 ttgggacaca tcatgtggga acacatcggt atggctcgta acgcagagag cttgaaagag
     5341 gctatccaga tgttgaaaga cttgaagaag gaattctgga gcaacgtatt cattccgggt
     5401 aacgcagatg acttgaacgt agagttggag aaagcattac gtttggcaga ctttatcgag
     5461 atcggtacct tgatggcaca tgacgcttta gaccgtgctg aatcttgtgg tggtcacttc
     5521 cgtgaggagc accagactga ggaaggcgag gcattacgtc acgatgacaa attcatgtat
     5581 gtctcttgct gggaatatca gggtgaggat aaagaccctg ttatgctgaa ggaagatttg
     5641 aactatgaat tcgtagttcc tcagacacgt aactataaga agtaatcaat cattgcaaaa
     5701 attagaatca tggataaaga tataaatatc acactcaaag tttggcgtca gaaaggtccg
     5761 aatgtaaaag gacaattcga aacttaccaa cttaaaaaca tcaaccaagg cacttctttc
     5821 ttggaaatgt tggatatcct gaacgagcaa ttaatcagcg aaggtaaaga acctgttgtt
     5881 tttgaccatg actgtcgtga aggaatctgc ggtatgtgtt cattgtatgt aaacggacat
     5941 ccgcatggac cggcaactgg ggctacgact tgccagttat acatgcgccg tttcaacgat
     6001 ggtgagacca tcacgatcga accgtggcgt tccgccggtt tcccggtaat ccgcgacttg
     6061 atggtagacc gttacgctta cgataaaatc attcaggcgg gtggtttcac atccgtaaat
     6121 accggtggtg tacccgacgc aaacgcaatt cctattccta agccagacgc agagatggca
     6181 atggatgccg ctgcttgtat cggttgtggt gcttgtgccg ccgcttgtaa gaacggttca
     6241 gctatgttgt tcgtatccgc taaggttagc cagttggctt tgttacctca aggtaaagtc
     6301 gaggctgctc gtcgtgcgaa agcaatggtc gctaaaatgg atgaacttgg cttcggtaac
     6361 tgtacgaaca cacgcgcttg cgagatggag tgtccgaaga atatctccgt tagtaacatc
     6421 gctcgtttga accgtgagtt catttgcgct aagctacaag actaatattt gattagtata
     6481 tcatggaaaa ggcgtctttc tctaaaagaa aggcgccttt ttatttttgt tatatgttga
     6541 aaaacataat ttagcactac agatcttgac aggaattgaa aagtccgtat atttgcatcg
     6601 tggttttttc ataatagtat tagatttaag gttaacaaag tttggttagg gcttgtcgtg
     6661 agacaggctt taattgttta tagacctacc ttttaaacat ggaccacaaa atactgcaaa
     6721 tagagattgt ttagcgtcat tttatcgtcg atctttgcct ttaaagatca tatagtatat
     6781 gctaataagt attttatttg gcttcttatg ttattttctc cgggtgttga tcaaacacaa
     6841 ggaaaaaatc atgcgccaga taagacaaat ggtaaaacaa aaataaaatg gacaaaaaac
     6901 gaaccaccag ttctttcagg gcaatgagca cggaaagaaa actcgagtcg atcttccttt
     6961 tcgtaacagg ccgatgcaac gccaaatgcg cgatgtgctt ctatgcccaa gaaatggata
     7021 agaagcaacc cgacctcact ttcgatgaaa tcaagaaaat atcagaaacc gctgggcaat
     7081 tcaaccgatt atggatatcc gggggtgagc ctaccctgcg tgaggatcta ccggaaatat
     7141 tggagttatt ctacaaaaac aaccatatca aagatgtgaa catccctacg aacggcttaa
     7201 aaccagaccg gatcgtcgaa tgggtaaaac ggttccgcca gaactgcccg gattgtaata
     7261 ttaacgtaag cctttccttg gatggtttcg gtacgaccca cgatacacag agaggtgtac
     7321 cgggaaactt ctataaggca ctggaaaccc tgcgtaagat acaggagaat ttcggagacg
     7381 acggcaaggt cctgaaaaat atagcaaccg ttatcacgaa atacaatata gaccaggtag
     7441 aagacttcat gacttgggta tacggacgtt tccgtacctc cacacatacg attgaggccg
     7501 ccagaggcat gacccgtgac gatggcgtga aaatcctaac cgagtcaacg ctacgcaaaa
     7561 tacaagatga catatcccct atctattcag cttatgcgga tcggatggta gcggatacca
     7621 ccggcttaag gaaaccgatc acacgcttct tctatctcgg ccttatacgt accttatata
     7681 atatacgtgc cagcaacata gatcacccga ccccttgggg gatggattgt acggccggag
     7741 aaactacctt ggtaatcgac tacgacggac gttttcgtgc ctgcgagcta cgggaaccgc
     7801 tcggaaatat aaaagagtat ggttgcgata taagtaaagt gatgaatagc gaagcgatga
     7861 aacaggaaat agccgctatc ggacatgggt ataaagccaa ctgttggtgt acgcacggct
     7921 gctggatcac ctcatccgtc attttcaatc cacgtaagat gattcgctcc gtatataaag
     7981 gataccggga aacgaaacga ttgaatcatc ccctagccat caatgagcag aaactacaaa
     8041 cgatggaagc caaataccat ctggatatcg agcgtttgcg tcaactgaat atccggtaaa
     8101 caagaccctc atagcccata aataaacgta gcatgaaaat actattagta accagaggct
     8161 cacaaggcga cgttcttcct tatttggcca tagcggccga attggaaaga cgtggccatg
     8221 aggtgaccat caatctccct caaatattcg aggagaccgt taaaccctac ggatttaaat
     8281 acgtattgca gcagtttgac gatatcggcg gcatgatcga tagcgcagcg caaaactcac
     8341 ataaattccg gccattcctt aaatggatga ggaacgtgat cgataaacag ttcgatcaat
     8401 tgattcccct actaaaagag catgatattt tagtatcgac caactcggaa tttgctgtcg
     8461 caagtatcgc cgagtattgc aagaagccct tgatacgtac cgcctacgcc ccgttcttgc
     8521 cgggtaagaa gattcccccg gccgtattgc catttcccaa acccaacccg atcatcactc
     8581 ccgctatcct atggaagttg atgaaccgga tgaccaattt catggtcaaa gacacgatca
     8641 ataagaaccg ggctaaatac ggactcgcgc cgattcgcaa ttttggctat cacgcgggag
     8701 agcgttcata taattacttg cttttcagcc agcacctagg aaacgtagat ccggactgga
     8761 cgttcgaatg gtcgatcgga ggctattgct tcaatgacac ttttcaatat gatgagaagg
     8821 cttacgagga aatgatatca ttcgtcgaca gcgctcaaag ccctattatc ttttttaccc
     8881 tcgggagttg tagttccaag gatggtaacc gtttcagcaa agccttggtc gatatttgca
     8941 agaaacatga ttatcggctc atcatcggtt ccggttgggc aaagacagga atcaccttac
     9001 aagcggataa acatttattc ttaatgaagc agccggttcc gcataatttg atattcccgc
     9061 actgcgacgg cgttatccat catggaggtt gcggcacgac ccatagcgta ggaagggcgg
     9121 gaaagcccca attaatcact ccgttgatta tcgatcaacc ctattggtcc tatcgaatcc
     9181 accaattagg gttagggccg gaaggagtta agatagcgaa agcgagcgag caggagatcg
     9241 aacgcaaggt ttgtgatctg gtcaccaatc cgctttataa gaaaaatgcc gctcatatag
     9301 gcgagatgat ccaaaaagag ggaggtataa agaatatatg cgactctatc gaaagatttc
     9361 aatgaggcat aagttcctat tagattttat tacatgttac aaaacacaat ttagcactta
     9421 atctattgac aaatagcggt aactccgtat atttgcatcg tggttttttc ataatagtat
     9481 tagatttaag gttaacaaag tttggttagg gcttgtcgtg agacaggctt taattgtttt
     9541 atgaggtctg cttcccgcaa agcccttcga ttacatcaga ataatccgat gcgtcaataa
     9601 agtcgatatc ttgtccttta agaccttccc attaatcggt ttcgccgtat aggcatcaaa
     9661 tccactttta ataatccgct gctcatcttg ggcgaaagcg taagccgtca ccgcgataat
     9721 aggcacgcta gcagaaacct tacgaatctc tgcggtagcc tcgtatccat ccatgaccgg
     9781 catctttata tccatcaaga tcaactgcgg tttgtgctga tgaaatagct ccacagcctc
     9841 ctttccattc catgcatgaa tcaatttata ttcaggtttc aatatagact caaacaggcg
     9901 ataattactg gaattatcct cagcgatcaa gatcgtaacc tcacttcggg cgatcttctc
     9961 caaagtaaca ggcttctgct cttcattagg caataattct ttcttcggct gaaaaggcaa
    10021 tgtaaaccag aacctagagc ctttcccttc cacggaatca acccctatcg ttcctttcat
    10081 ctgggtaaca atcatctcac agatgcttaa acccaatcct gttccttgag cgaaagtatt
    10141 cagtttcaca aaacgtccga aaatatcttt ccgtttattc tccgggattc cgcagcccgt
    10201 atcctctaca tagaaccaca acgtattatc atcccgcagt ttatagccaa atgagatcga
    10261 tcctgcctgc gtaaatttca tggcattgtt caacagattg atcatcagtt gggacagacg
    10321 atttcgatcc gtataaatca cgcaaggctc cagataatcc ttaaatgaga tctgtacatc
    10381 cggattctta ttcttcaaat gagccgattg ctccaaatcc ctcaatacag cgttaatatc
    10441 cacatagtca taagtaaact ccaaggtacc cgcctcgatc tttgataaat ccaagatatc
    10501 gtttatcaac tgcaacaata gggaattatt attctcgata atatcagcga attccttctt
    10561 atcctcaagg ttatcggtcg aggcgaggat attagagaaa cctacgatcg cattcaacgg
    10621 tgtacgtatc tcatggctca tattagctaa aaacgcagat ttcaatttat tcgactcctc
    10681 cgccttatcc ctagccattc gaaggtcatg ttccaattgc ttacgctcgg taatagatat
    10741 cgtagacccg atcaacgctt tcggtttacc ggaagcatca tattcggcca ttacctgtat
    10801 ctcctcccac tcatggcgat cttctcccgg aatcaaccgc tccagacaat attcttttcg
    10861 tactttcttt attttcccat tacacaaatc atcgaaagcc ttttccacgc aagccctgaa
    10921 agacgggtgt atcttgctga aatattcctc caacgaaacc tcatgggtat gtatctcggc
    10981 agtctctata ttatcttccg gatgtacttt cgactcatag ataatcttcc cttcagccag
    11041 attatatcgc cacggcaaaa gatctgccgc ctctaacgcc atagccagct tatgattcat
    11101 ggctttcaaa tgcgtctgga atttatggat atccgtaata tcaataaaaa acgcgtcaac
    11161 tacattctct tccgaggtag gcatgatgat aatcgtatag taaagccctg tcggctcaaa
    11221 ataatactca taagtgaagg attttccact ctctaaaacc gtaggcactg ccgataggag
    11281 caaaggataa ctcccgccaa tcaaatttgc gatctctttt ccacgcttat ttaccacaaa
    11341 atctttagga gcgattttct cctcgaaagc atggttcaca tctaaaacct gcacatcgat
    11401 ttgcgtacct tcccgaatca gccgctgccg tatataaggt aacggcatat tattaaataa
    11461 atcacggtaa cgggacaaca acctcaactc tacttccttc atcttttgtt tagaacgata
    11521 cacataatac cccgctaaaa acactactac cagaaagaat atcagaaagc ctaacagctg
    11581 catccaatat ttttccaaga aagagggagg cgcattcaaa tagatcgcat cacgcgggaa
    11641 attatcttca ttagatatcg cacttatcaa cgaagcataa ttcaagtatt tatgaggatc
    11701 atttaccgtc gaaaccggga tcttgcccat atcttcaccg ttataaactt gttgtagtaa
    11761 ggggattaga gcagtctcaa tcgttttagc actattataa tatccaccaa tcgtatatcc
    11821 ttcttccacg cccatatcat ataaagaaaa aacaggatgc ctagaaatgc cgtttatacc
    11881 ttgatacaaa gtactatata ataacgagtg attcaagaaa ggcttctcgg taatccacga
    11941 gtaatacatc acggccgtcg ctcgatgtgg gtctttctcc gacagaaccg ccattaaact
    12001 atccatggag caagaaccct ccgtataaaa atccactttc ccctcaggga aagaagtttc
    12061 catatgtttc tccatctcat cccgaagcca tgtggagaca taacgtctgt cggatatgaa
    12121 aatcagacgt ttcaaacccg ggattaattc cttcaccaag tcgatcgaac ctttaacata
    12181 ataagggata accaagcccg tagcgttata ccccttaacc gcctcttgta aagggatcac
    12241 cctatcagag gaatgcctct gattaaaata acattcatct tctgccattt cacccgtttc
    12301 cgaacagacc agagtgggaa tatcccccca tttctcccgg atcttatccc gcataaaagc
    12361 ccatccattt acgcctaagt agataattcc atccggcttc ttcttattaa cttcaaagaa
    12421 ggcctcttgc ttctctttta atttctctgg cgtatcaacc aacatcacgc tcatatgatc
    12481 tatccggagg gtgtactcct ccggggtagc gaacttcgag attatgttta ataaattgcc
    12541 agaccagcgt tcgccatcca catatgaatt tatcaccaat acatacgatt catccttgac
    12601 cggatatgaa aaactcccat aagccggagt cggcataccg gctatcaagc ataaaatcaa
    12661 tccaaaataa agtattattg cctttaaatt tataatattt cgtatcattc cctacattcc
    12721 tctattgcag ttgtaaagac aaagatattc cttaattatc aactaatctt atcaaactag
    12781 tttttttatc aagttttggt gtcaaattca cgtttcttac aaactaaagg cttttttaat
    12841 cgggattatt cggttattta ccgatactcg tatagaaatc agcggtattt acttgtgtat
    12901 agaatgacga acccgtacat ttgataaaaa acaaaaaaat ggaacttatg gatatgaaag
    12961 attatgacat cgattttaaa gagaagagga caaacgggta tctgatcgct accttattta
    13021 tcattgtcgg tatattattt ttactgcgga atctaggaat gatagatcca tctttatttg
    13081 acttgcttgt atcttggccg atgctgcttg tcgtgtcggg catctttatg attttccacc
    13141 gtaatccggt aggaggtatg ctcctcgtgg gcgtgggagt ctatttcctt ttcccgcagt
    13201 taaattggat cacgaacgat ttcttacgtg tatattggcc gttaggatta atcctgttag
    13261 gattggtcat catgctgaag cggaaagatt ctatccgcac gaaaaagcat aaacgtccct
    13321 ttaaccatcc ccctttcggg caccgaaagc ctaacgatga gatcaactac gagacagata
    13381 acggtttcgt atcggttgac accactttca actcggtaag gcacatcgta ctggaccccg
    13441 tattcaaggg ggcggacata gacgtatctt tcggcaacgt gatcctcgat cttaaaaaaa
    13501 caacattaga ggctgatgaa accatcataa acatagatag ctccttcagc ggcgtagtaa
    13561 tatatgtccc taaaggatgg ctggttcgtc taaaggttga ttccttcttg gctggatgcc
    13621 aagatatgag ggacctgaca gaaacaaccg acatgacgca cacgttgtat atatgtggag
    13681 acttgtcgtt cagcggcctt gaactaagag actaaactca tcatgcaaga acatcctatt
    13741 acaacatcca tattacataa agggctggga agcctattat tacttttagc catagcgatc
    13801 caatgcgcat tattaactct ttatggcgat cttccgttga gcatcacttt ggtcgatagc
    13861 ttactttcca tcgcattgtt cgccgtagcg ggatattatc tttggtatgt acaatgtacg
    13921 ttacatatca tgcaagcacg agtggctttc gccgtactcg tacaaatcgc ttgcatagcc
    13981 ggatgctcga tcttgctaca aatattcgga ttggaagatt gggaggaatt ctcgatcacg
    14041 attccttttc gattcctgtt cggcctaatg gcatggatca ttctatccca atggtatgcc
    14101 agccgggaaa gaaagagtga ggtggagctt atcgtgagac aaatggagga aaagacggca
    14161 cctcccccga ctaccgttcc ggaggagatt ctagatcgta tatccgtaaa agacgggaca
    14221 cgtattcata tcatcccgat aaaagagata ttctatttac aagcatgtgg cgactatgtg
    14281 accttattca ccacttccgg tcagcacgta aaggagcaaa ccatgaagta tttcgagcga
    14341 agccttcctt ctccggagtt cgttcgtata catcgctctt atatcgttaa tacggaacag
    14401 atattgcgag tagaactatt cggaaaagaa acctatcaag tacgattaaa ggatggaacc
    14461 tatcttcgtg ccagtagcgc tggctataag ctactcaaag aacgtctttc cctttagcag
    14521 tcctataaaa gggacctaat catcgttaaa attagaagat tttgattgta atatatagag
    14581 ttttatgttg tgtaacactt tttggcaagc atcgatatgt tacttaacat atattagttg
    14641 caaaagactt gacaaatggt cttgacgaac gtatctttgc atcgtggttt tttcataata
    14701 gtattagatt taaggttaac aaagtttggt tagggcttgt cgtgagacag gctttaattg
    14761 tttataggga tttgcttccc tagatttaca tataactata aaaaaacggc cacccctaaa
    14821 aagaggcggc cgtaattata ccataagata ggatttctat tcctcaacaa tacctacgac
    14881 ttccatttca aaaatcatcg tagtgcaagg ttttacaaca acagccccgg tattaggatt
    14941 cttatatccc gcttctccat atccaagttg cgagggaacc caaatctccc atttatcacc
    15001 gggatgcata ttctgtaaag ccgtggcaaa gccatcagtc atcttgtaca cttccatcac
    15061 cgcaggctct ccagcctcga aagaacgatc atcaaaaact tcaccattta taaaagagcc
    15121 tttataataa cattccacct tgctcgtata ataaatcggc tccttactct ccccagtctt
    15181 caagaccttg taaaggataa atccggcatt actttgagaa ctcaattgct cgaaacccgg
    15241 aaccagcatc tgggcttgaa aagcctcctc attctggatc ttccaaacct catccacctc
    15301 tagtgcctca tcatcatccc cacaagaggt gatcatgagc acgcaaaaca acatcaacgc
    15361 aatatgccag tacttcttca ttcgtttact ctattacctt tttcaataaa ttcttcatgc
    15421 tcaccttctc cgtgataata tcgtgaagct tatcgatgct tacgcgctct tgctccatcg
    15481 tgtcacggaa acggatcgtt acgcaattat ccttcaaggt gtcatggtct accgtaatac
    15541 aatacggggt accgatcgca tcctgacgac gataacgctt accaatagaa tccttctcgt
    15601 cgtattggca acggaagtcg aaacgcaaca tatttataat ctcctcagct ttctcgggca
    15661 ggccatcttt cttcaccaat ggcaatacgg ccaatttgat cggagccaag gctgcgggca
    15721 acttcaatac cacacggctc tcgccattcg ccaacgtctc ctcgcagtaa gaacccgcca
    15781 tgatgctcaa gaacacacgg tctacaccga tcgaggtctc gattacatac ggagtgtaac
    15841 tctggttcaa ctccggatcg aaatattgga tctttttacc ggaaaacttc tcatgctgac
    15901 tcaagtcgaa gttcgtacgg ctatgtatac cctccacttc cttaaatccg aatggcatct
    15961 cgaactcgat atccgtagcc gcgttagcgt agtgagccaa tttctcatga tcgtgatagc
    16021 gatacttctc atcgcccaaa cctagggctt gatgccattt caaacgagta gacttccatt
    16081 tcttaaacca ctcgatctcc tcacccggac gaacgaagaa ttgcatctcc atttgctcga
    16141 actcacgcat acggaagata aactggcgag ccacgatctc attacggaac gccttaccga
    16201 tctgggcgat accgaacggg atcttcatac ggccagtctt ctgcacattc aagaagttca
    16261 cgaaaatacc ttgggccgtc tccggacgaa gataaacctt catcgctcca tcagcggtag
    16321 aacccatatc cgtagagaac atcaagttga actggcgaac ctccgtccag ttacgagttc
    16381 cggaaatcgg gcaaacgatc tcgcaatcca agatcaattg gcgaagatcc tcgaagttag
    16441 actcgttcat cgccttgcta taacg
//
