LOCUS       c00020_gnlPro..        13259 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AIGEPHNL_20.
ACCESSION   c00020_gnlPro..
VERSION     c00020_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 22:50:34
            Original ID  :: gnl|Prokka|AIGEPHNL_20
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13259
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13259
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:3259]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..3259
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13259
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13259
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..1408)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.4e-27, bitscore:
                     84.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTQQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRIFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNR
                     HTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQM
                     ISARYFKYTRERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKI"
     CDS             complement(1456..1800)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_2"
                     /sec_met_domain="ILVD_EDD (E-value: 7.7e-44, bitscore:
                     139.8, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAA
                     AGGNIGKIVDGDIIEIDIPARTINVRVTDEELAARPMTPVTRDRYVPKSLKAYASMVSS
                     ADKGAVRLID"
     CDS             complement(1877..3259)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_3"
                     /sec_met_domain="ILVD_EDD (E-value: 3.5e-150, bitscore:
                     490.7, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTKLFEDAAKLIVENAMKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILEELAKGG
                     LIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGGGGKNWKVYRPCQSIRLTRS
                     SL"
     CDS             3734..4309
                     /locus_tag="ctg20_4"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYTVEDGEKELFEETNAEHPFQFISGLGTTL
                     ESFENQITALSKGDKFDFTIPADEAYGAYDEQHVFDLPKNIFEIDGKFDSERVTEGSIV
                     PLMTGDGQRVNASVVEIKPDVVVVDLNHPLAGADLIFEGEVIESRPATNEEIQELVKMM
                     SGEGCGCGCDSCGSDCGDDCGCEGGHCH"
     CDS             complement(4441..5730)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_5"
                     /sec_met_domain="SDH_alpha (E-value: 1.1e-62, bitscore:
                     201.8, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIESERKQIIDLIKKEVIPAIGCTEPIAVALCVAKAAETLGMKPE
                     KIEVLLSANILKNAMGVGIPGTDMVGLPIAVALGALIGRSEYQLEVLRDCTPEAVEQGK
                     LFIAEKRICISLKEDITEKLYIEVICTAGSQKATAVIAGGHTTFVYIATDEKVLLDKQQ
                     TANEEEEDASLELNLRKVYDFALTSPLDEIRFILDTARLNKAAAEQAFKGNYGHSLGKM
                     LRGTYEHKVMGDSVFSHILSYTSAACDARMAGAMIPVMSNSGSGNQGISATLPVVVFAE
                     ENGKTEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGNYNQVA
                     FAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAMMAMEDRCVTSVEGIIDEDVDQ
                     SIRNLTRIGSQAMNETDKMVLDIMTHKGGC"
     CDS             5864..6949
                     /locus_tag="ctg20_6"
                     /transl_table=11
                     /translation="MKAKHGILYLLLAIFSSSCIREEAPNAEADILSCRLPGVVMTTSP
                     IITNNSINIFVGPGTDISSLAPEFTLTPGATIDPPSGTARDFHSPQQYTVTAADGFWKK
                     KYTVSVIDTELATIYNFEDTLGGQKYYIFVEREGEKVVMEWASGNAGYAMTGVPKTADD
                     YPTFQFANGKTGKCLSLVTRSTGFFGSIMGMPIAAGNLFIGSFDVGNAMSNPLKATKFG
                     LPFRHIPTYLAGYYKYKAGDQFTEGGKPVSGKRDICDIYAIMYETSESVPTLDGTNAFT
                     SPNLVSIARIDDAKETDEWTYFKLPFHMLSGKYIDKEKLTAGKYNVAIVFTSSLEGDHF
                     NGAIGSTLLIDEVELIYRSED"
     CDS             7040..7825
                     /locus_tag="ctg20_7"
                     /transl_table=11
                     /translation="MKIHSYIFSLLACLVIALPGYSQVDRNETLIRSALHGLEYEIKAG
                     FSIGGTAPLPLPVEIRSIDGYNPTLAISIGGEVTKWFAVQNKLGVIVGLRLENKAMTTE
                     ATVKNYNMEILGQGGERISGVWTGGVKTKVHTSGLTIPLMATYKLSNRWNIKAGPYFSY
                     LLSREFSGHVYEGYLREGDPVGPKVEFTDGKIATYDFSDDLRHFQWGLQIGAGWRAFKH
                     LNIYADLTWGLNDIFRNDFQTITFAMYPIYLNIGFGYAF"
     CDS             complement(7841..8404)
                     /locus_tag="ctg20_8"
                     /transl_table=11
                     /translation="MKKNLLYLWALICSVSLLTACSSDDDNTVNDETTPPEEEAVVTAP
                     DVVGTYWGNLDISMLPDGSDQEVVIADGLPKFITFSQVSDTEVKMELKEFELFINGNIL
                     KFGDIVIDKCAVKKETDASTFTGQQDLTFQGDAAALGTCATSIEGTVQSGNATMNIQVK
                     VPALKQTVKVTFSGVKQVEESGKD"
     CDS             8563..9639
                     /locus_tag="ctg20_9"
                     /transl_table=11
                     /translation="MFNSFGNIFRLTSFGESHGKGVGGVIDGFPSGITIDEEFVQQELN
                     RRRPGQSILTTPRKEADKVEFLSGIFEGKSTGCPIGFIVWNENQHSNDYNNLKEVYRPS
                     HADYTYKVKYGIRDHRGGGRSSARETISRVVAGALAKLALRQLGISITAYTSQVGAIKL
                     EGTYSDYDLDLIETNDVRCPDPEKAKEMADLIYKVKGEGDTIGGTLTCVIKGCPIGLGQ
                     PVFGKLHAALGNAMLSINAAKAFEYGEGFKGLKMKGSEQNDVFFNNNGRIETHTNHSGG
                     IQGGISNGQDIYFRVVFKPIATLLMEQETVNIDGVDTTLKARGRHDACVLPRAVPIVEA
                     MAAMTILDYYLLDKTTQL"
     CDS             9741..11105
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_10"
                     /sec_met_domain="Peptidase_M20 (E-value: 1e-38, bitscore:
                     122.9, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEIQKYIAANEPKIMEDLFSLIRIPSISALPEHHDDMLACAQRW
                     AQLLLEAGVDEALVMPSKGNPIVFAQKIVDPNAKTVLVYAHYDVMPAEPLELWKSQPFE
                     PEVRDGYIWARGADDDKGQSFIQVKAFEYLVKNELLKNNVKFIFEGEEEIGSPSLEAFC
                     EEHKELLKADVILVSDTSMLGAELPSLTTGLRGLAYWEIEVTGPNRDLHSGHFGGAVAN
                     PINVLCEIISKVTDKDGRITVPGFYDDVEEVPQAEREMIAHIPFDEKKYKEAIGVKELF
                     GEKGYSTLERNSCRPSFDVCGIWGGYTGEGSKTVLPSKAYAKVSCRLVAHQDHHKISQM
                     FADYILQMAPDTVQVKVTPMHGGQGYVCPISLPAYQAAEKGFEIAFGKKPLAVRRGGSI
                     PIISTFEQVLGTKTVLMGFGLESDAIHSPNENFSLDIFRKGIEAVIEFHQEYAKR"
     CDS             complement(11231..12289)
                     /locus_tag="ctg20_11"
                     /transl_table=11
                     /translation="MKKKLTGVALVLAAVSLMGIQPAGACTRAVYLGPDRMVVTGRTMD
                     WKEDIMSNIYVFPRGMQRAGHNKEKTVNWTSKYGSVIATGYDIGTCDGMNEKGLVASLL
                     FLPESVYSLPGDTRPAMGISIWTQYVLDNFATVREAVDEMKKETFRIDAPRMPNGGPES
                     TLHMAITDETGNTAVIEYLDGKLSIHEGQEYQVMTNSPRYELQLAVNDYWKEVGGLQML
                     PGTNRSSDRFVRASFYIHAIPQTADAKIAVPSVLSVMRNVSVPFGINTPEKPHISSTRW
                     RSVSDQKNKVYYFESTLTPNLFWLDLKKIDFSPKAGVKKLSLTKGEIYAGDAVKDLKDS
                     QSFTFLFETPVM"
ORIGIN
        1 taatcttcac cggagctttc tgttccatga tcgtacccag ctcctgaatg ttcatttgca
       61 gtccgccgtc acccataaat acacatacag tgcggtcggg acggccgaaa gtagctccga
      121 tagctgccgg aaggccaaaa cccattgtgc cgagtccacc cgaagtaacg atactacgtt
      181 ccctggtata tttaaagtag cgggcagaga tcatctgatt ctgacctaca tctgtcacca
      241 atatggcttc gtgacgggtc gcttcgctta ccgcacgcac cacttcgccc atactcagtg
      301 aatccgttgc aggatgaagt tcaggacgaa tgactttttc ttcctctacc gcttcatatt
      361 ccttgaaact atcgacccac tcggtgtgcc ggttcttttt caacagtccg gtcacagcag
      421 ccagcgtctt tttgcagtcg cccaaaacgg caatatctac ctttacattc ttatttactt
      481 ccgccggatc aatgtcaaaa tggatcactt tcgcttgttt ggcgtaagta gccagattac
      541 cggtcacacg gtcgtcgaaa cgcataccga cagcaatcag tacatcacat ttgttagtat
      601 tgatattcgg tcccagattt ccgtgcatac ccagcattcc tttattcaac ggatggtcgg
      661 taggcaatgc ggaaagtccg agcaaggtac aacctgcggg catatccgcc ttttcgataa
      721 agatacgcag ttcttcctga gcgcttccca gttccactcc ctgtcctacc aagacaagcg
      781 ggcgttcggc gttattgatc agttcggcgg cagcctttac cgattcttcg tctgtatcgg
      841 gaaccggaac atagctgcgg ataaactcct gctgcgtcgg ctcgtatttt gttttttcaa
      901 cctgcgcatt cttggcaaag tcgagtacca ccggaccagg acgaccacta ctggcaatgt
      961 agaaagcacg tgctatcgcc caggctacgt cttcggcacg gcgaatctga taactccatt
     1021 tagcgattgg ctgagtgata cctacgagat cgacttcctg aaaagcgtct gttccaagga
     1081 agcctgttcc cacctgtcct gcaatgacaa cgataggcgt actgtctatc atcgcatctg
     1141 caatacctgt gatcgtattg gttgctccgg ggccgcttgt caccaagcaa acaccgactt
     1201 tacccgatac acgggcgtag ccttgtgccg catgggcagc tccctgttca tggcgaacca
     1261 agatatggtt caatgtattt tgatggtcgt acagggcatc gaacgtaggc atgatggaac
     1321 cgccgggata accgaaaatg gtagtcactc cctgatgttc cagagagcgc atcattgcct
     1381 ctgcgcctgt tattaagtcc ttactcatag ttctttaatg gataatggat gattcataat
     1441 ggataatgaa gtggatcagt ctattaatct cactgctccc ttatcggcag agcttaccat
     1501 gctggcgtat gctttcaggc tcttcggcac gtaacggtca cgggtgacgg gagtcatcgg
     1561 gcgggcagcc agttcttcat ctgttactcg cacgttaatc gttcgggcgg gaatgtcgat
     1621 ttcgatgata tctccatcta ctatttttcc tatattacct ccggcagcgg cttcgggaga
     1681 aacgtgtccg atactcaatc cggaagttcc accactgaaa cgtccgtcgg taatcaaggc
     1741 acattctttg ccgaggtgac gggatttgat ataagaagtc gggtaaagca tttcctgcat
     1801 accgggaccg cccttcggac cttcgtgcgt gatgacgaca acgtcgccgc tgacgactcg
     1861 gcctccgagg atgccttcac aggctgcttc ttgtgagtcg aatactttgg cagggccggt
     1921 aaaccttcca gttttttccg cccccccccg ccgtttttac tacgcaaccg tcctgagcga
     1981 tatttccttt cagtaccgcc aggcctccgt ccttgctata ggcgtgctcc agatcacgga
     2041 tacatccgtt cgcgcgatct ttatctaatt cctgataata agctccctga gaaccaagta
     2101 cgagattgaa tctgtttcct gccgcacttg aatatttgct cattgctttt tccgtaacgt
     2161 tcgggctggt aattgaatat tgatcgatcg cttccgccag cgacatgcca tccacacgga
     2221 gaacggaagt atcaatcaga ccgccttttg ccaactcttc caggatagca atgatgccac
     2281 ccgcacggtt aacgtcctga atatgatatt tttgagtatt cggagcgact ttacacaggc
     2341 agggtgtctt gcgtgacagc atatcgatgt cgtccatctt gaaatcgact cctgcctcat
     2401 gtgccacggc caacaggtga agcaccgtat tggtagaacc gcccatcgca atatccagcg
     2461 tcatggcatt gaggaatgcc tgacgggtag ctatgctgcg gggaagtaca ctttcgtcac
     2521 cttcttcata atatttcatt gcattttcca caatcagttt ggcagcatct tcaaacagtt
     2581 tcgtacgatt ttcgtgcgta gccacgattg tgccgtttcc cggaagagcc aagccgatag
     2641 cttcattcag acagttcatc gagtttgccg taaacattcc ggaacaacat ccgcaggtag
     2701 gacaggcatt ctgttcgata ttcgctactt cctgatcgct tacactgtcg tccgctgatt
     2761 taatcatggc atcgatcaag tccagatgct gaccgttcca ctctccggct tccatcggtc
     2821 cgccggatac aaatacggta gggatattca ggcgcatggc agccatcagc atccctgggg
     2881 taatcttatc gcagttgctg atacatacca ttgcatccgc cttgtgcgca ttgaccatat
     2941 attctacgct gtccgctatg atatcacggg aaggaagcga gtaaagcatt ccgtcatgtc
     3001 ccatagcgat accgtcatca atagcaatcg tattaaattc cgcagcgaag catcccagct
     3061 tctcaatttc cgccttcacc aactgcccga tttcatgcag gtgcacgtgt cccggaacaa
     3121 attgtgtaaa cgaattgacg atagcgataa tgggttttcc catctgattt ttcttcatgc
     3181 cgttggctgc ccataatgcg cgggctcccg ccatgcgacg gccttgtgta ctaaacgaac
     3241 tgcgtaattg ctttttcatt tcaatctatc ttttaattaa agagcctccc tcacatcagt
     3301 gagaaaggct ccaaattcta tcttttatgg tacgaataca tacacaaaac ctttctcacg
     3361 ctcttgatgg caccaccacg acgcgaataa tatgcagaac tgctaggtta atagatgtat
     3421 gtaatatatt catatcttct tttctttatt ttcgtgctgc aaaggtaagg gcttttttat
     3481 tatctccaaa caaatcgaag aaaaaaatca ctaaaaagcg aataatcgta agaaaagaac
     3541 ggtaataaac ctaaatttta tcacttaaag gttgaatttg caactatcag ttagtagaga
     3601 atgactgtcc atttctgaca aaagcgctta ataatctgaa atttactccg tatgcacccg
     3661 gtagcaagca aattattcgt atctttgtcc accctaaata agggatttat taattagaaa
     3721 ctataaatat cagatggaaa cagtagaaaa caagtacatc accgttgcat ataagctata
     3781 tacagtggaa gatggtgaaa aagaattgtt cgaagaaaca aatgcagaac atccttttca
     3841 gttcatttca ggattaggca caacgctcga aagcttcgag aaccagataa cagctctttc
     3901 taagggtgat aaattcgatt ttaccattcc ggcagatgaa gcttatggag cctacgatga
     3961 gcaacatgta tttgatcttc ctaaaaatat ctttgaaata gatggcaagt tcgacagcga
     4021 acgcgtaaca gaaggcagca ttgtaccttt gatgaccgga gacggtcaac gcgtaaacgc
     4081 cagcgtcgta gaaatcaaac cggatgtagt agtagttgac cttaaccacc cattggcagg
     4141 cgctgacctg atctttgaag gtgaagtaat cgaaagccgt cctgctacca acgaagaaat
     4201 tcaggaactg gtgaagatga tgagcggtga aggttgcggt tgcggatgcg acagctgcgg
     4261 cagcgactgt ggcgatgact gcggttgcga aggcggacac tgccactaat tttaagtaat
     4321 aggtaataag tattaagtat taattccatg cggatatagg cggaagttaa tacttaatac
     4381 tttttttatg ccgttattcc agctattacc tattacttat tacttgttac ttattacttg
     4441 ttaacatcct cctttgtgcg tcatgatatc aagcaccatc ttatccgttt cgttcatcgc
     4501 ctgcgagccg attcttgtca agttacgaat gctttgatcg acatcttcgt caataatgcc
     4561 ttctacagaa gtcacacaac ggtcctccat tgccatcata gcagataata cggctgttga
     4621 gactccggtt gttactttga gtgcgcagct cggttttgca ccgtcgcaaa tcattcccgt
     4681 caggttggca atcatgtttt gaacggcaaa ggctacctga ttatagtttc cacccatcag
     4741 ccaggtgatt ccgcaactgg aacccgtggc agctactaca cagccacaca aggcagagag
     4801 acgtcccaaa ctttgtttaa tatagattac agtgagatga ctcagcatta aggcgcggat
     4861 cagttcctct tcggttttac cattttcttc ggcaaatacg acaacgggaa gtgtggcgga
     4921 tatgccctga ttgccactgc cggagttact catgacggga atcattgcac cggccattct
     4981 ggcgtcgcaa gcggcggaag tataagatag tatatgagag aatacgctgt cacccatcac
     5041 tttatgttca tacgttccac ggagcatctt acctaaagaa tgcccataat tgcctttaaa
     5101 ggcttgctcg gcggctgctt tgttcagacg tgccgtatcg agaataaaac ggatttcatc
     5161 cagaggggat gtcagggcaa aatcatagac tttgcgcaga ttcagttcca gtgaagcgtc
     5221 ttcttcctct tcattggcag tctgttgctt gtcaagcagt actttttcat ccgtagctat
     5281 atagacaaag gtagtatgtc cgccggcaat cacagccgtc gctttttggc tgccggctgt
     5341 gcagattact tcgatgtaca gtttttccgt aatatcttct ttgagagaaa tacagattcg
     5401 cttctctgcg ataaacagtt tgccttgttc tactgcctcc ggtgtgcagt ctctcaacac
     5461 ttccaattga tattccgatc ggccgatcaa cgctcccaag gctacagcta taggaagtcc
     5521 gaccatatct gtgccgggga taccgactcc cattgcattc tttaatatat tggcactcaa
     5581 taacacttca atcttttccg gtttcattcc taatgtttcg gcagctttag ctacacaaag
     5641 cgctaccgca atgggttccg tacaccctat cgccggaatc acctcttttt tgatcaagtc
     5701 tattatctgt tttctttccg attcaatcat accctataag gctttagttt ccacaaaagt
     5761 agaaaattct tttttatcaa acatccatta gtgaacaaat aaaattgcag attgttataa
     5821 aatcttccaa gaaccgaact ttaacagtta gaatagtaga aaaatgaaag caaaacacgg
     5881 tattctttat ttgctgctag ccattttctc ttcttcttgc attcgcgaag aagctcccaa
     5941 tgcagaggca gacatactca gttgcagatt gccgggagta gtcatgacaa cgagtccgat
     6001 tatcactaat aattccatca atatatttgt aggaccggga acggacattt catcccttgc
     6061 acccgaattt acattgactc cgggagccac tatcgatcct cccagtggga cggctagaga
     6121 tttccattcg cctcagcaat ataccgttac ggctgccgat ggcttttgga agaagaagta
     6181 caccgtatcc gttattgata cggaacttgc tactatttac aattttgagg atacgctcgg
     6241 cggacagaaa tactacatct tcgtagaacg ggaaggagaa aaagtggtga tggaatgggc
     6301 cagcggaaac gcaggttatg caatgaccgg agttcccaag acagccgacg actatccgac
     6361 ttttcagttt gcaaacggaa aaaccggaaa atgcctgtcc ttagtaaccc gcagtaccgg
     6421 attcttcggt agcattatgg gaatgcctat cgcagccggg aacctgttta tcggctcttt
     6481 tgatgtagga aatgcaatga gcaatccact gaaagcgacc aaattcggtc tgcctttccg
     6541 gcatatacca acttatctgg caggctatta caagtataaa gccggagatc agtttacaga
     6601 aggcggcaaa cccgtcagtg gcaaacggga tatatgcgat atttatgcca tcatgtatga
     6661 aaccagtgaa tctgtgccga ctcttgacgg aacgaatgct ttcaccagtc ccaacctggt
     6721 ttcaatagca cgcattgacg acgccaaaga gacggacgag tggacatact ttaaacttcc
     6781 ctttcatatg ttatccggaa aatacataga taaagagaag ctaacagcag gaaagtataa
     6841 tgtagctatc gtattcactt ccagcctgga aggagatcat tttaacggag ctatcggaag
     6901 tacattgttg attgatgaag tcgaactaat ctatcgctcg gaagactgat tccattcgac
     6961 caacgatctg atagcagcta tggaaggcag aacagagcaa ctataatgaa ataactaatg
     7021 atttaataat aatgaaaaga tgaaaatcca ttcctatata ttcagtttac tcgcctgtct
     7081 ggtgatagcc ctccccggct attcacaggt tgacagaaac gaaacactta ttcgctccgc
     7141 tcttcacgga ctggaatatg aaatcaaagc agggttcagc atcggcggta cagccccgct
     7201 cccgctgcct gtcgaaatcc gttcgattga cggctacaac ccaacgctgg ctatcagcat
     7261 cggaggagaa gtaaccaaat ggtttgccgt tcaaaacaag ctcggagtca ttgtagggct
     7321 gcggctggag aataaagcca tgacaacgga agccaccgtc aaaaactata atatggaaat
     7381 cctcggacag ggaggagaaa gaatcagcgg tgtctggaca ggaggagtca aaaccaaagt
     7441 ccacacttcc ggactgacaa ttcctctaat ggctacttac aagttgagca accgttggaa
     7501 tattaaagcc ggaccttatt tttcgtatct gctttcaaga gaattttcgg ggcacgtata
     7561 tgaaggatac ctgcgtgaag gcgaccccgt aggccccaaa gtcgaattta cggatggtaa
     7621 aatcgctact tatgacttct cggacgacct gagacatttt cagtggggcc tgcaaatagg
     7681 agccggatgg agagcattca aacacctcaa tatatatgca gacctcacct ggggattgaa
     7741 tgatatcttc agaaatgact ttcagaccat tacttttgct atgtatccga tctacttgaa
     7801 tatcggattc ggatatgctt tctagctgac caaagacgga ttaatcctta ccggattcct
     7861 ccacctgctt cacaccggag aaagtaactt tcacggtctg cttcaatgca ggtactttta
     7921 cctgaatatt catcgtagca tttccacttt gcactgttcc ttctatactg gtggcacagg
     7981 tacccagagc agcggcatcc ccctgaaaag taaggtcttg ctgtccggtg aaagtcgaag
     8041 cgtccgtttc ctttttcacc gcacacttgt ctatcacaat atcgccgaac tttaatatgt
     8101 ttccgtttat aaacagttca aattccttca gttccatctt tacttccgta tcgctgacct
     8161 gagagaaagt aataaacttc ggaagtccgt cggcaatcac aacttcctgg tcggagccat
     8221 cgggcagcat tgaaatatcg agatttcccc aatacgttcc caccacatcg ggagcagtca
     8281 ccacagcctc ttcttccgga ggagtcgttt catcattgac cgtattatcg tcatcactgc
     8341 tacaagccgt caaaagagag acagagcata tcaatgccca caaatacaat agattctttt
     8401 tcataatttt cgggtttagt tattaaataa tcgtcattta taaactaaaa agaggaaaaa
     8461 aggttcaatt tgcttccttt tccgaagata ttttgaattc acaaccttct tatcgaaaac
     8521 tttgttatat ttgcatagag taattttaaa aaagccacaa ctatgtttaa ttcatttggc
     8581 aacatctttc ggctcaccag cttcggcgag tctcatggaa aaggagttgg gggagtaatt
     8641 gacggatttc cttccggaat cacaatcgac gaagaatttg tacaacaaga actaaatcga
     8701 cgccgtccgg gacaatccat cctcaccaca ccacgcaagg aagcggataa agtggagttt
     8761 ctttcaggca tcttcgaagg caaatcaacc ggatgtccta tcggatttat cgtttggaac
     8821 gagaatcaac attccaatga ctacaataac ctgaaagagg tataccgccc ttcacatgcg
     8881 gattacacct acaaagtgaa gtacggcatc cgtgatcatc gcggtggcgg acgttcttct
     8941 gcccgcgaga ctatttcacg cgtagtagcc ggcgcattgg ctaaattagc ccttcgccag
     9001 ttaggaatca gcatcacagc ttatacatcg caagtcggtg ccatcaaatt ggaaggcact
     9061 tattccgact atgatctcga cctgatcgaa acaaacgatg tacgttgtcc ggaccctgaa
     9121 aaggcgaagg aaatggcaga ccttatatat aaggtaaaag gcgaaggcga taccatcgga
     9181 ggtacgctga cctgtgtcat caaaggatgt cctatcggat tggggcaacc cgtattcggc
     9241 aagctgcacg ctgccttggg caacgccatg ctcagtatca atgccgccaa agccttcgaa
     9301 tatggagaag gattcaaggg actgaagatg aaaggctccg agcagaacga cgtattcttc
     9361 aacaacaacg gacggattga aacgcatacc aaccactccg gaggtattca gggaggaatc
     9421 agtaacggac aggatattta cttccgtgta gtattcaaac cgattgctac cctgctgatg
     9481 gagcaggaaa cggtgaacat cgacggcgta gatacgacat tgaaagcccg cggacgtcat
     9541 gacgcctgtg tactgccacg tgccgtacct atcgtagaag caatggctgc catgaccatc
     9601 cttgattatt atctgttgga taagacaacg cagctttaat aagtatcaat atgtcaatct
     9661 acccatgtgc caatacctgc actaaaaatc tgtcaggcta ttggcacata ggctaaataa
     9721 ccgccagtaa actattcatt atgaacgaaa ttcaaaaata tatcgcagcg aacgaaccga
     9781 agattatgga ggacctgttc agcctcatcc gtattcccag tatcagcgcc ctgccggaac
     9841 atcacgacga tatgctggct tgcgcccaac gctgggcaca actactgctc gaagccggag
     9901 tggatgaagc attggtgatg ccttccaagg gtaacccgat tgttttcgca caaaagatcg
     9961 ttgacccgaa tgccaaaaca gtattggtct acgcccacta cgacgtaatg cctgccgaac
    10021 cgctggaact gtggaaaagc cagcccttcg aacccgaagt acgggacgga tacatctggg
    10081 cacgcggagc ggatgatgac aaaggacaat cctttatcca ggtcaaagcc ttcgaatatc
    10141 tcgtcaagaa cgaactgctg aaaaataacg tcaagtttat cttcgaagga gaagaggaaa
    10201 tcggctctcc cagcctggaa gccttctgcg aagagcataa agagctgttg aaagcagacg
    10261 ttatcctggt ttcggatacc agcatgctgg gtgccgaact tccatccctc accaccggtc
    10321 tgcgcggact ggcttactgg gaaatagaag tgaccggacc gaaccgtgac ctgcattcgg
    10381 gacacttcgg aggtgcggta gctaatccga tcaatgtgct ttgcgaaata atcagcaaag
    10441 taacagataa agacggaaga atcaccgtcc ccggattcta cgatgacgta gaagaagtac
    10501 cgcaagcaga acgggaaatg atcgcccata ttccgttcga tgagaagaaa tacaaagaag
    10561 ccatcggagt gaaagaactc ttcggagaaa agggatacag cacactggaa cgcaacagtt
    10621 gccgcccgtc tttcgatgta tgcggcattt ggggaggata tacaggtgaa ggctccaaga
    10681 cagtccttcc ctcgaaagcg tatgcgaaag tttcctgccg actggttgcg catcaggatc
    10741 atcacaagat ttcgcagatg tttgcagatt atatcttaca aatggctccc gacaccgtac
    10801 aggtaaaagt aaccccgatg cacggaggac agggatatgt ctgcccgatt tcccttcctg
    10861 cctatcaggc tgcggaaaaa ggttttgaga tagctttcgg caaaaaaccg ctggcagtac
    10921 gtcgtggcgg aagtattcct atcatttcga cattcgaaca ggtattagga accaaaaccg
    10981 tattgatggg cttcggactt gaatcggatg cgatccattc acccaacgaa aacttctcgc
    11041 tggacatatt ccggaaagga atagaggcag tgattgagtt ccaccaggaa tatgcgaaaa
    11101 gataaaggct gcctatagcc gcacgcagga cacgaagata aaaggagaac ggtagacaag
    11161 cggataaatc ctttgcctac cgttcctttt tattcaaaaa aagacctctt accacataac
    11221 taactatcga ctacatcacc ggagtttcga aaaggaaagt aaatgattga ctatccttca
    11281 aatccttcac ggcatctcct gcgtaaattt ctcctttggt caaggacagt ttcttcaccc
    11341 cagccttcgg actaaaatca atcttcttca aatccagcca aaacaggttc ggagttaaag
    11401 tagactcaaa gtaatacact ttattcttct gatcggaaac ggaacgccag cgagtagaag
    11461 aaatgtgagg cttctccggt gtattgatac caaacggaac ggagacattg cgcatcacac
    11521 tcagcacact ggggacagct atctttgcat cggcagtctg cggaatggcg tgaatgtaga
    11581 aagaggcacg cacaaaacgg tcgctcgaac ggttcgttcc cggcaacatc tgcaatccac
    11641 ccacttcttt ccagtaatca ttgacagcca actgcaattc ataacgcgga gaattggtca
    11701 tcacctgata ttcttgtccc tcatggatac tcagtttgcc atccagatat tcgatcactg
    11761 ccgtgttgcc tgtttcatcg gtaatagcca tgtgtaaagt agattccggt cccccgttcg
    11821 gcatacgggg agcgtcaata cggaaagtct cttttttcat ttcatctacc gcctcacgca
    11881 ccgttgcaaa attgtcaagc acatattgag tccagatact gattcccatt gccggacggg
    11941 tatctccggg aagtgaataa acagattccg gcaagaagag caagcttgcc accagtcctt
    12001 tttcattcat tccgtcacaa gtacctatat catagcctgt tgcgattacg cttccatatt
    12061 tggaagtcca gtttactgtt ttttctttat tgtgtcccgc acgctgcatt ccacgtggaa
    12121 acacatagat atttgacata atgtcttctt tccagtccat cgtgcgacca gtgaccacca
    12181 ttcggtccgg ccccagatat acggcacgcg tacatgctcc cgccggctgt atgcccatca
    12241 aagagacggc agctaacacc aatgcaacac ccgtaagttt tttcttcata ttacttccaa
    12301 attaaatagt tgatactctt atatctataa taacaaatat acaacgtata ttgcctgaga
    12361 gagagaaaaa tttaagggaa aaaagggaat ttattcagaa aaaatcttat ccgctcttat
    12421 ttgagttaaa aaagcctgcg gatggaagga aacattacac attatttgct tttcaaatgg
    12481 gatttcatta tttttgtaca taacctatca taaaaactaa ggagggcaaa tgcgtatgag
    12541 acaaaaagtt agcatatcac agcttccaat tcgtttggga atctttcttt tgctgtattt
    12601 tgttccgcaa tcactctctg cgcaagaaaa caacgacagt acgcacatac ttcgtaacgg
    12661 tgcatccata acgccggacg acgtactaaa acaggccaac attaacttgt ttccagaaaa
    12721 gagcactaca tattctttat attcacccgg acagttggag catatacccc gcttttcact
    12781 caaaagggat atttccctgc cttatcagac caatccttcc ctactcttcc gaggtgatta
    12841 cagtacgggc ggggtattgc atcaattcga tcgtggagca ctgttcggtt ccggaagtca
    12901 gacaagtatg gcaggcatcg ggcgtttcaa cagtgcttca ctaggttatc agcatatttt
    12961 caatgagcaa ttcgagttac aagtccgtgc caatgcgctg aagctcaaca tgtcccacat
    13021 caccggacag gctttcagca cttcgggcgc cttcctttac catccttccg accgtgtcac
    13081 cttgaaagtc ttcggatcat acgacatcgg aaactcttac ggaatgagca cccatagcta
    13141 cggagctacg atgtccgtcg atatgtccga ccgctttggg atggaaatgg gagtacagcg
    13201 atactatgat gcgatgagcg gacgttggga aacggttccc gttatgattc cttactacc
//
