LOCUS       gnlProkkaBMGDPBIK_39   13929 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BMGDPBIK_39.
ACCESSION   gnlProkkaBMGDPBIK_39
VERSION     gnlProkkaBMGDPBIK_39
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 22:27:30
            Original ID  :: gnl|Prokka|BMGDPBIK_39
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13929
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13929
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2555:3929]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2556..3929
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13929
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13929
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             55..447
                     /locus_tag="ctg39_1"
                     /transl_table=11
                     /translation="MNIQSKMKTRDAKNNPVTAVLVSVLVMFLLSCLFLLLLAALLYKF
                     DLSESAVKVGIVVIYIVSGVIGGFFMGKIMKTQKFLWGFAAGAIYFCILFLISVLVKQG
                     VSMELPKVATTFILCAASGMAGGMIS"
     CDS             590..1981
                     /locus_tag="ctg39_2"
                     /transl_table=11
                     /translation="MERQKRQGAEYEFYGKLPLKKAIPLGLQHVLAMFVGNLTPILIIS
                     GACGIAGEEFGSLQVDLLQNAMLIAGIVTLIQLFAIGPVGGKVPIIMGTSSGFIGVFNS
                     VVQVMGGGILAYGAIMCASVIGGLFEGILGFLLKPLRRFFPAVVTGTVVLSIGLSLIAV
                     GVNSFGGGNTANDFGSVENLLLGAAVLLIIVAVKHWMKGMASASSILIGIVAGYIIAAI
                     MGLVLPTTAVNADGVEYTKAWVLNWDKVANAAWFSVPKLMPVKLVFDWRAIIPVLIMFV
                     VTAVETVGDISGVMEGGMGREATDKELSGGVICDGIGSSLAALFGVLPNTSFSQNVGLV
                     TMTKIVNRMALASGAVFLILCGLFPKLAALISIMPQSVLGGAAVMMFSSIVISGIQLIT
                     KEPMTMRNITIVSVALGLGYGIGSSSGILAHLPQGIQLIFGGSGIVPAAIVAIIFNIIL
                     PKDAE"
     CDS             2556..3929
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Quinohemoprotein_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_3"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.5e-34,
                     bitscore: 108.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Quinohemoprotein_rSAM_RRE (E-value:
                     1.6e-10, bitscore: 31.4, seeds: 15, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 8.1e-17, bitscore: 52.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1e-13, bitscore: 42.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-18, bitscore:
                     57.6, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHQYKNNGYDIVLDVNSGAIHVVDDVTYDVIEMIDQSQPESYAR
                     DEIVSALSGKYGKEEVEEAVDEVQTLIDEESLFTKDTYENYIMDFKKRPTVVKALCLHI
                     AHDCNLACQYCFAEEGEYHGRRALMSFEVGKKALDFLIANSGNRRNLEVDFFGGEPLMN
                     WQVVKDLVAYGREQEKLHDKNFRFTLTTNGVLLNDEIMEFCNKEMANVVLSIDGRKEVH
                     DKMRPFRKGAGSYDLIVPKFQKFAESRHQDKYYVRGTFTHYNPDFAADVLHLADLGFKQ
                     ISVEPVVAEPSEPYAITEEDLPQLFEEYDKLAAEMVRRHKEGDDFNFFHFMIDLEGGPC
                     VAKRLSGCGSGTEYLAVTPWGDFYPCHQFVGNEKFLLGNVDEGIKNTEIRDEFKCCNVY
                     AKEKCRKCFARFYCSGGCAANAYNFSGDICGAYDIGCELQKKRIECAIMIKAAEADCE"
     CDS             3955..6114
                     /locus_tag="ctg39_4"
                     /transl_table=11
                     /translation="MKKSKAAVILVAILAAFAGLAYYASIILSSTGIGEEMSIPLGLDL
                     SGGVSITYQVMDENPSAEDMSDTIYKLQKRVESYSTEASVYQVGDDRIAVEIPGVTDAS
                     KILEELGNPGSLEFQLSDGTVFMTGDQVADAQAATTTDQYGNKQYVVQLTLTDEGAKTF
                     GEVTSENVGKALPIVYDGEVISYPTVQEAITGGTAQISGQSTFEEAQTLATQIRIGSLS
                     LQLSELESSVVGAQLGSQAISSSLKAAAIGLVIVMVFMIIVYAVPGVAAALALAIYTAL
                     VIATLYLFEITLTLPGIAGIILSIGMAVDANVIIFARIREEIASGKSVITAMKNGFHKA
                     MSAILDGNITTLIAAIVLMGLGSGTVKGFAYTLMIGIILSMFTALVVTRWILYSFYWLG
                     MRDEKFYGRAKERKTINFLQKRYVFFAISIAVIAAGFIGMGVHKASGQNSLNYGLDFMG
                     GTSTTADFGEEYTIEDIENDIIPVVKEVTGDSNIQANKVEGTTQITIKTRTLSKEERDD
                     LNNKLADSFDVDESTITFQSISSTISGEMRADAVKAVIISTICMLIYIWFRFKDIRFGA
                     SAIIALIHDVLVVLTVYALMRISVGNTFIACMLTIIGYSVNDTIVIFDRIRENLALKHG
                     KQTREDLMEVANRSLTQTLSRSINTSITTFIMVFMLFLLGVASIREFALPLMAGMICGA
                     YSSICIATELWYVMKVHLGKNKITE"
     CDS             6404..6601
                     /locus_tag="ctg39_5"
                     /transl_table=11
                     /translation="MADLRKNVVFSQHFRRQYRNVGGNVCVPPQDETLVFCYGNAADPH
                     FTDRRCHLALSSGLISFIII"
     CDS             6733..7974
                     /NRPS_PKS="Domain: Aminotran_1_2 (77-368). E-value:
                     1.2e-15. Score: 49.4. Matches aSDomain:
                     nrpspksdomains_ctg39_6_Aminotran_1_2.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg39_6"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4e-16, bitscore:
                     49.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTLEDIQAVDMEVANAITDEFERQNSHIELIASENWVSKAVMSA
                     MGSVLTNKYAEGYPGKRYYGGCECVDVVEELARERAKELFGCEYANVQPHSGAQANMAV
                     QFAILKPGDTVMGMNLDHGGHLTHGSPVNFSGTYFHIVPYGVNDEGFIDYDKVEEIAME
                     CKPKMIIAGASAYARTIDFKRFREIADACGAVLMVDMAHIAGLVAAGLHPSPIPYAHVV
                     TTTTHKTLRGPRGGMILSSQEIADKYNFNKAIFPGIQGGPLMHVIAAKAVCFKEALQPE
                     FKVYQQNIIDNAQALCKGLLSRDIKIVSGGTDNHLMLVDLTNYDQTGKAVEKLLDSVNI
                     TCNKNTIPNDPKSPFVTSGVRLGTPAVTSRGLNTEDMDQIAEAIAMMIKEGEPAADKAC
                     AIVKSLTEKYPLER"
     aSDomain        6964..7836
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg39_6_Aminotran_1_2.1"
                     /evalue="1.20E-15"
                     /label="ctg39_6_Aminotran_1_2.1"
                     /locus_tag="ctg39_6"
                     /protein_end="368"
                     /protein_start="77"
                     /score="49.4"
                     /tool="antismash"
                     /translation="RERAKELFGCEYANVQPHSGAQANMAVQFAILKPGDTVMGMNLDH
                     GGHLTHGSPVNFSGTYFHIVPYGVNDEGFIDYDKVEEIAMECKPKMIIAGASAYARTID
                     FKRFREIADACGAVLMVDMAHIAGLVAAGLHPSPIPYAHVVTTTTHKTLRGPRGGMILS
                     SQEIADKYNFNKAIFPGIQGGPLMHVIAAKAVCFKEALQPEFKVYQQNIIDNAQALCKG
                     LLSRDIKIVSGGTDNHLMLVDLTNYDQTGKAVEKLLDSVNITCNKNTIPNDPKSPFVTS
                     GVRLGTPAVT"
     CDS             complement(8063..8887)
                     /locus_tag="ctg39_7"
                     /transl_table=11
                     /translation="MKLFKQITCAVLTLCLCAGLLLIPSAPVSAATGPSAPKAVDVSYY
                     KNYPMVNDSAISVQLGTNGKNIKNIKTSSKNLKAKVTRLSLSSSSNSGYVGVYAKKTGK
                     YTVSFDVYNAQNKKIKKFTVKVNVTEPTFSNNSPFKSVTFNNKEYDYAKAVYNKNSVKV
                     NVKMNKGYKLKKIEYSTYSKPVAKTNSSYSTTYSNSEITKKVKNGKSIQLGHYGYYYGH
                     DYSYAYGTYSYESYSRDGDIMAPTIVKITYLDKNKNTISTSYTLYRIADDVK"
     CDS             complement(8909..9655)
                     /locus_tag="ctg39_8"
                     /transl_table=11
                     /translation="MKIFKRTVSLFLAFCLCAGMLLLQPQSTVSAAVRNKPTTTVLRMS
                     SNSFDSSAIYVNLPKAKVCYIKNIKTSSKNLIAKNTHYYTTSSDDTYTDTFASIGLYAK
                     KTGKYKVTYNICDKSGNKLSSGKVTVYVKNDLPVKSVKFAGKEVNYALTSKKSGKLSVK
                     MNKGYTLKKITVTTYNKAGKEVVKTMKNNSTLKLGEYAYIFDNSYSSGRNYSTSLAART
                     KITITYIDKYTKQECESIYSISRLAK"
     CDS             10324..11229
                     /locus_tag="ctg39_9"
                     /transl_table=11
                     /translation="MGGINFLKELTYQYLRLAHKDLQEKLGDSLSVDTSLNREDSFLKN
                     YKKSSAKGYQTKKAYLIRGEKLRPGEFGVMHGYMKIPELKRVCHAMEISINEYLVSVYI
                     WSVYTECLHGMPSKCPIRVAVPVNLRPYFNSITTKNFFVMVSAEFHPTKETYTFAEVAA
                     IVKESLRSQINRENLEKLFSYNVSNEKLLIARVVPLFLKNLAMKYVYTTSALANTATIT
                     NIGNISVTEEYRPYVEMFHAFLAMSKGQHLKGTICSYGDTLVFSFSYDLVDASVQRGFF
                     RKIASDGIAVEIKSNGVNYE"
     CDS             11222..11887
                     /locus_tag="ctg39_10"
                     /transl_table=11
                     /translation="MSKCRNCNVEISDETERCPLCGSVLEYTGEVENMYPDVRVHTRKM
                     TMISKIYLFCALLVEVLLIYINVVTESQIAWSAITGLGFFYGYMLIRFAILGKTGYRAK
                     ITVLTLMAILIVIAIDFLVGYRGWSVNYALPSAIILVDVGIIICMIVNRRNWQSYMMWQ
                     IFMILCSIVPVILIFTGIVTAQLFALIAFAFSLFLFLGTLIIGDRRARVELKRRFHVR"
     CDS             11923..12849
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066:alpha/beta hydrolase domain-containing protein
                     (Score: 222.6; E-value: 1.1e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg39_11"
                     /transl_table=11
                     /translation="MRESEASIRGRVMRDLIAHVTNDHLIGKKIKNGELRKKIGDSEPP
                     WKCPDCFSLDVIEMDNFSMEYLQAKENPNTEKVILQLHGGGYVGAMRNAYRMFAGLYCE
                     VSHGMSVLTPDYRVAPEHPYPAALEDAYAAYCYLLEQGWFSEQIIIAGDSAGGGLAMAL
                     CHYLKDHGKQLPCGIVAMSPWTDLAASGESYETNFERDPLFGKTRDSLIYNKDYIGDND
                     PYNAYISPLYGDFRGFPPMLIQVGSYEMLLSDSVDVAAKAREQGVKVRISIYEGMFHIF
                     QMAAKMLPESKRAWVEIGKFIDVLLND"
ORIGIN
        1 acgaaaggtg cattttttcc ttccggtgac catactgcaa atagtggagt gtcaatgaat
       61 atacagtcaa aaatgaaaac aagagatgca aaaaacaatc cggtcactgc ggtattggtg
      121 tccgtgctgg tcatgttcct tttaagctgc ctgttcctgt tactgttggc tgcactgtta
      181 tataagtttg atctgagtga atcggcagta aaggtgggaa tcgttgtcat ttatatcgtc
      241 tccggagtga tcggtggatt tttcatggga aagatcatga aaacacagaa atttttatgg
      301 ggatttgcag cgggagccat ttatttttgc attttattcc tgatatcagt gctggttaaa
      361 cagggagtct ccatggaact gccgaaagtg gcgacaacat ttattctatg tgcggcatcc
      421 gggatggcgg gcggaatgat aagttagtgg ttactgtcag ggtgccaatt agcatataga
      481 caggacttgc gcagaatatc agcggcgtgc tatactcaaa gaaaatgtgc atgaatgaaa
      541 aaaattatca atgtttcatg cagaaaaaga tacgcacgag gaggaagaca tggaaagaca
      601 gaagagacag ggagcagagt acgagtttta cggaaaactc ccgctgaaaa aggcaatccc
      661 gctgggatta cagcatgtgc tggcaatgtt tgtgggaaac ctgacaccga tcctgatcat
      721 ctcaggggca tgtggtattg caggtgagga gttcggcagt ctgcaggtcg atctgctgca
      781 gaatgcgatg ctgatcgccg ggatcgtgac actgatccag ttatttgcga tcggaccggt
      841 tggtggaaag gtaccgatca tcatgggaac gagttccgga tttatcggtg tgtttaacag
      901 tgtggttcag gtaatgggag gaggaatcct tgcatatgga gcaattatgt gtgcatccgt
      961 cattggtggt ctgtttgagg gaatccttgg atttctgtta aagccgctcc gcagattttt
     1021 ccctgcggtt gtaacgggaa ccgttgtact gtcgatcgga ttgtcactga tcgcggtcgg
     1081 cgtcaattct tttggcggcg gcaatacggc aaacgacttt ggttcagtag aaaatttact
     1141 gctcggagca gctgttttac tgatcattgt agcagtgaaa cactggatga aaggtatggc
     1201 gagtgcatca tcgatcctga tcggtattgt ggcaggctat atcattgctg cgatcatggg
     1261 actggtactg ccgacaacag cagtcaatgc ggatggtgtg gaatacacaa aagcctgggt
     1321 gttaaactgg gataaggttg caaatgcagc ctggttttcc gttccgaaat taatgccggt
     1381 caaactggta tttgactgga gagcaatcat tccggttctg atcatgtttg ttgttaccgc
     1441 ggttgaaaca gtcggagata tctccggtgt tatggaaggt ggaatgggca gagaagctac
     1501 cgacaaagaa ctttccggcg gtgtcatctg tgatggaatc ggttcttcgc ttgcagcact
     1561 ttttggtgtt ctgccgaata cttctttcag tcagaatgta ggacttgtca caatgacgaa
     1621 aatcgtaaac cgtatggcgc ttgcatccgg agccgtattc ctgattttat gtggtttatt
     1681 cccgaaactt gcagcactga tttcaatcat gccgcagagt gtacttggag gagctgccgt
     1741 tatgatgttt tcatccatcg tgatcagcgg aatccagctt attaccaaag aaccgatgac
     1801 gatgcgcaat atcacgatcg tctccgtcgc attgggactt ggctatggaa tcggatccag
     1861 cagcggcatc cttgcacatc tgccgcaggg catccagctg atctttggcg gttccggtat
     1921 tgttccggca gccattgtgg cgatcatctt taatattatc ctgccgaagg atgcggaata
     1981 aaaaaaactt cccatatgaa aaaagttatg ttatactgta taagttaaca gaactccgcg
     2041 cgaaagcgaa taaatacata gtattacggg gagcgggcaa atggcgtatc ccatgtgtgc
     2101 ggaaattaca aaaaaggaga gaagcatcat gaaacatgta aagacattaa ataccaagag
     2161 attacagaac acaatcaaaa aaggcggctg cggcgagtgc cagacatcct gccagtctgc
     2221 atgcaaaaca tcctgtacag taggaaacca gagctgcgag cacaaataag atttgagctg
     2281 gtacggccgg gcatgcatag catggtaaaa attgtgcata tgagtgccgg atatgccatt
     2341 atggcatcat acaaaatgac tgtgtgatac aacgatgaaa atcatacggt cggatataag
     2401 tgaaatctgc aaacgaccgt tcgcatagcg tgcggtcatt tgtacgtttt atcggcaaca
     2461 ttaaaatgcc gtaatacttg aaaaaaatat attgatttgc agaaaacttt aaatgttttg
     2521 ctgtaaaatc agatagaaag agaggaaata ttatagtggt tcatcagtat aagaacaacg
     2581 gctatgatat tgttttagat gtaaacagcg gagcgattca tgtggtggat gacgtgactt
     2641 atgatgtcat tgagatgatc gatcagagcc agccggaatc gtatgcaagg gatgagatcg
     2701 tatctgcact gtccggaaaa tacggcaaag aggaagtgga ggaagcagtc gatgaagtcc
     2761 agacattgat cgatgaggag tcacttttta caaaggacac ttacgaaaac tatatcatgg
     2821 atttcaaaaa acgcccgacg gttgtcaagg cactctgcct gcatatagca catgactgca
     2881 acctggcatg tcagtactgc tttgctgagg agggagagta ccatggaaga agggcactga
     2941 tgtcctttga agttggaaag aaagcactgg atttcttaat tgccaattca ggtaacagac
     3001 gaaatcttga ggtggatttc tttggcggcg agccgcttat gaactggcag gtcgtaaaag
     3061 acttagttgc ctatggaaga gagcaggaaa agctgcatga caagaatttc cgttttacac
     3121 tgaccacaaa tggtgtgctt ttaaatgacg agatcatgga attctgcaac aaagagatgg
     3181 caaatgtggt cttaagtatc gatggaagaa aggaagttca tgataagatg cgtccgttcc
     3241 gcaaaggggc aggaagttat gatctgatcg ttccaaagtt ccagaaattt gcagagagca
     3301 gacatcagga caaatattat gtgcgtggta cattcacaca ctacaatcct gattttgcag
     3361 cagatgtact tcatcttgcg gatcttggtt tcaaacagat ctccgtggag ccggtagttg
     3421 cagaaccgag tgaaccgtat gcgatcacag aggaagatct tccacagctg tttgaggaat
     3481 atgacaaact tgcagcggag atggtaagac gtcacaaaga gggagatgat tttaatttct
     3541 tccattttat gatcgatctt gagggcggtc catgtgtggc aaaacgtctg tccggctgtg
     3601 gttcaggaac cgagtacctt gcagtgacac catggggaga tttttatcca tgtcaccagt
     3661 ttgtcggcaa tgaaaagttt ttacttggca atgtggatga aggtataaaa aatacagaga
     3721 tccgtgatga gtttaagtgc tgtaatgtct atgcaaaaga aaaatgcaga aaatgtttcg
     3781 caagattcta ctgcagcggc ggatgtgcag caaatgcgta taatttcagc ggtgacatct
     3841 gtggggcata tgatatcgga tgtgaattgc agaaaaaacg tattgagtgc gcgatcatga
     3901 tcaaggctgc cgaggccgat tgtgaataaa taagaaacag gaaggaaaaa gaaaatgaaa
     3961 aagagtaaag cagcagtcat attagttgcg attctcgctg catttgcggg acttgcctat
     4021 tatgcatcta ttattctttc atcgactggt attggggaag aaatgagtat tccgcttgga
     4081 cttgatctgt ccggtggtgt atcgatcacc tatcaggtca tggatgaaaa tccgagcgca
     4141 gaggatatga gtgatacgat ttacaaactc cagaagcgtg tggaaagtta cagtacagag
     4201 gcatccgtat atcaggttgg agatgatcgt atcgccgttg agatcccggg tgttacggac
     4261 gcaagcaaga ttttggaaga acttggtaat ccgggttcct tagagttcca gctttcagat
     4321 ggtaccgtat ttatgacggg tgaccaggtg gcagatgcac aggctgcaac aaccacagat
     4381 cagtatggaa acaagcagta tgtggtacag cttacactga cagatgaggg agcaaagact
     4441 ttcggagaag ttacttctga aaacgtcgga aaagcacttc caatcgtata cgatggagaa
     4501 gttatcagtt atccgactgt tcaggaggca attaccggag gtactgcaca gatttccggt
     4561 cagagcacct ttgaagaggc acagacttta gcaacacaga tcagaatcgg ttctctttcc
     4621 ctgcagttat cagagttaga gtccagtgtg gtaggagcac agcttggaag ccaggcaatc
     4681 tcctccagtt taaaagcggc agcaatcggt cttgtgatcg taatggtatt tatgatcatt
     4741 gtatatgcag ttccgggtgt cgcagcagct ttagcacttg caatttatac agcacttgtg
     4801 attgcaactt tatacttatt cgagatcaca ttaacattac ctggtattgc cggtattatc
     4861 ttaagtattg gtatggcagt ggatgcgaac gttatcatct ttgcacgtat ccgtgaagaa
     4921 attgcatcag gaaaatccgt gattactgca atgaagaatg gtttccacaa agcgatgtct
     4981 gcaatcttag atggtaatat cacaacattg attgcagcga ttgttcttat gggattaggt
     5041 tccggtactg taaaaggatt tgcatataca ctgatgatcg gtattatcct ttccatgttt
     5101 acagcacttg ttgtcacaag atggatcctt tattctttct actggttagg aatgagagat
     5161 gaaaaattct acggacgtgc aaaagagaga aagacgatca atttcctgca gaagagatat
     5221 gtattctttg caatttctat tgcagttata gctgccggat ttatcggtat gggagtacat
     5281 aaggcatctg gtcagaattc cctgaattat ggacttgatt ttatgggagg aacttccact
     5341 accgctgatt ttggcgaaga atatacgatc gaagatattg aaaatgatat tatcccggtt
     5401 gtaaaagaag taactggaga cagcaatatt caggcaaaca aagtagaggg aacaactcag
     5461 attacgatca agacacgtac tttatccaaa gaagagcgtg atgatctgaa taataagctg
     5521 gcagacagtt ttgatgtaga tgaatccacc attacattcc agagtatcag ttccacgatc
     5581 agtggtgaga tgcgtgcgga tgcagtcaag gcggttatta tctccacaat ctgtatgctg
     5641 atctatatct ggttccgttt taaagatatc cgtttcggtg ccagtgcgat cattgccctg
     5701 atccacgacg tactggttgt acttaccgta tatgcgctga tgcgtatttc agtcggcaat
     5761 acatttatcg catgtatgct gacgatcatt ggttattctg tcaacgatac gatcgttatc
     5821 tttgaccgta tccgtgagaa ccttgcatta aagcatggaa aacagacaag ggaagatctg
     5881 atggaagtag caaaccgaag cctgacacag accttatcac gaagcatcaa cacatccata
     5941 acaacattta ttatggtatt tatgctgttc cttcttggtg tagcaagtat tcgtgaattt
     6001 gcgctgccac tgatggcagg tatgatctgc ggtgcatatt catctatctg cattgcaacc
     6061 gagttgtggt atgtgatgaa agttcatctt ggtaaaaata aaataacaga ataagatctg
     6121 ttgaagaaaa gtgaaagtcc tggcagttat ttgccgggac ttttaagatt cataggaaat
     6181 tacgtcctat gaatcttaaa gccctccggg cgggatcaca ctgcgtcgga gatgaattat
     6241 gtcgcggagg cgacaccgcc gcaggcggtg aatcctgtag gacaggattc tattttagaa
     6301 aaaaggagaa acatatggat acgatcgcag cttatctgat ctttttaaat ctggtgggct
     6361 tccttattat gggagaggat aaaagaaggg cgaaaatgca tcgatggcgg atctcagaaa
     6421 gaatgttgtt tttagtcagc attttaggcg gcagtatcgg aacgtgggcg ggaatgtatg
     6481 tgttccgcca caagacgaga cactggtatt ttgttatggg aatgccgctg atcctcattt
     6541 tacagatcgc aggtgccatc tggctttatc gtcagggctt atatcattta taataatttg
     6601 atataactat tctggcattt ggaattgcca aaaaaaggaa agtcatatat aatgataaac
     6661 atagcaaaaa acaagtgttt ttcgtagaaa gacacattga tcaaacagca aagaaaggga
     6721 gaattacgga ttatgtatac actggaagat attcaggcag ttgatatgga agtggcaaat
     6781 gccatcaccg atgaatttga acgtcagaac agtcatattg agctgattgc atccgaaaac
     6841 tgggtaagca aggcagtgat gtcggcgatg ggcagtgttc ttacaaataa atatgcagaa
     6901 ggttatccgg ggaaaagata ttacggcgga tgtgagtgtg tggatgttgt agaggaactt
     6961 gcaagagagc gtgcgaaaga gctgtttggc tgtgagtatg cgaacgtaca gccacattcc
     7021 ggtgcacagg cgaatatggc tgtacagttt gccatcttaa aaccgggtga cacggtcatg
     7081 ggaatgaact tagatcacgg cggacatttg acacacggaa gccctgtaaa cttttccggt
     7141 acttattttc acattgtacc ttacggtgtc aatgacgagg gatttattga ttatgacaaa
     7201 gtagaagaga tcgcgatgga gtgcaagccg aagatgatca tcgcaggtgc aagtgcttat
     7261 gcgagaacca ttgatttcaa gagattccgt gagatcgcag atgcatgcgg agcagttctg
     7321 atggtcgata tggcacatat cgcaggactt gtcgctgcag gacttcatcc aagcccaatc
     7381 ccgtatgcac acgttgtcac aaccacaaca cacaagacac tgcgtggacc gcgtggaggt
     7441 atgatcttat ccagtcagga aatcgcagac aaatataact ttaacaaagc tattttccct
     7501 ggaatccagg gcggaccttt gatgcatgtg atcgcagcga aagcagtctg ctttaaggag
     7561 gcacttcagc cggagtttaa agtataccag cagaatatca ttgacaatgc acaggcactc
     7621 tgcaagggac tgttaagccg tgatattaaa atcgtatccg gcggtacaga caatcacctg
     7681 atgcttgttg atctgacaaa ttatgatcag accggaaagg cagtggagaa acttctcgat
     7741 tctgtcaata ttacctgcaa caagaatacg atcccgaacg atccgaaatc cccattcgta
     7801 acaagcggtg tacgtcttgg aacgccggca gttacttccc gtggactaaa cacagaggat
     7861 atggatcaga ttgcagaggc aatcgccatg atgatcaagg agggtgaacc ggcagctgat
     7921 aaagcgtgtg caatcgtaaa atcgctgaca gagaaatatc cgctggagag ataaaagaga
     7981 atagaatata atttaataat gaataaaaaa tgaggaacct gtttcgtgac aggttcctct
     8041 ttttttgtga cctttgagtt tgttatttta catcatctgc aatacggtac agtgtgtacg
     8101 aggtagaaat cgtattttta tttttatcga gatatgtgat tttcacgatt gtcggtgcca
     8161 taatatcacc atcacggctg tatgactcat aagagtaagt accatatgcg taagagtagt
     8221 catgtccgta atagtatcca taatgtccta actggatact ctttccattt tttacctttt
     8281 ttgttatctc ggagtttgaa taagtggttg aataggaaga atttgttttt gcaactggct
     8341 tgctgtaagt agagtattcg atcttcttta atttataacc cttgttcatt ttgacattga
     8401 ctttgacaga atttttattg tagactgcct ttgcgtaatc atattctttg ttgttaaaag
     8461 ttacactctt aaaaggacta ttgttagaga atgtcggctc ggttacattg actttgacag
     8521 taaatttttt aatcttttta ttctgtgcat tatatacatc aaaagatact gtgtatttac
     8581 cggttttctt ggcatagaca ccaacgtatc cggaattact ggagctggaa agtgaaagtc
     8641 ttgttacttt ggctttcagg tttttgctcg atgttttgat atttttgatg ttttttccgt
     8701 ttgtaccgag ctgtacggag atagccgaat cattgaccat cggataattt ttgtaataag
     8761 aaacatctac agcctttggg gcgcttggac ctgttgcagc agataccggc gcagaaggga
     8821 tcagtaataa tccggcgcac aggcaaagtg taagaacagc gcaagtaatt tgcttaaata
     8881 atttcatatc agatatcctc ctgttggatt attttgcaag acgggaaatg gaataaatac
     8941 tctcacattc ctgcttggta tatttgtcga tataagtaat agtgatcttg gtacgcgcag
     9001 caagtgaggt agaatagttt ctgccgctgg aatatgaatt atcaaatata tatgcgtact
     9061 cgccaagctt taaggtgctg ttgtttttca ttgtttttac aacttcttta cctgccttat
     9121 tgtaagtggt gacagtgatt tttttcagcg tgtaaccttt gttcatttta acagataatt
     9181 tgccggattt tttgctcgta agggcataat taacttcttt acctgcaaat ttgacagatt
     9241 tgactggcag gtcatttttt acatatactg ttactttacc cgaagaaagt ttgtttcctg
     9301 atttatcgca gatattatag gtgactttgt atttaccggt ttttttggca tagaggccga
     9361 tagacgcaaa ggtatccgtg tatgtatcgt ctgaactggt agtataatag tgggtgtttt
     9421 ttgcaatcag atttttactg ctggttttga tgtttttgat ataacatact ttggcttttg
     9481 gcagattgac atagattgca gaactgtcga aagaattact ggacatgcga agtacagtgg
     9541 tggtcggttt gttcctgacg gctgcggata ccgttgactg cggctgcagt aaaagcatcc
     9601 cggcacagag acagaaagct aaaaataagc tgactgttcg tttgaaaatt ttcataagtg
     9661 aatccttctt gtttataaat attttataga tgttacaaaa acattataat atgaaggaaa
     9721 attttataca atcataaatt aaaaaataaa taagggaatt ttaagaaaat ttatagcatt
     9781 atatcaggta attttgatat gcccaaactt gtattttatg tcaggttatt ttataattgc
     9841 atacaataga ttgtgtattt tatgagcggg gggagagaag aaaaaacaga aacccagcct
     9901 gcctgtaaaa tatgcagaaa cgaggaatat atgaaaaaac agaataaagg agttccgaca
     9961 aaccgtgata tccgttggga cagacttgat aatacagcac acctttttcc ggtcattgcc
    10021 ggggagagca tgagcaatgt gtacaggatc agtgttacac tgaaagagga gatcaatccg
    10081 gaattactgc agagggcact tgatatggtg cttccgaagt ttgacgggtt taacttaaga
    10141 ctgcggcagg gggtgttctg gtattatttt gaggaaaacg gaaaagcggc gccaaaggtt
    10201 cgcatggaga acaattttcc atgtagatat atccagcaga ataaaaaccg cagttatatg
    10261 ttccgtgtga cctattataa atgcaggatc aatctggaag tattccatgt tttgacggat
    10321 ggaatgggag gaatcaattt cttaaaagag ctgacttacc agtatctgcg tctggcacat
    10381 aaagacctgc aggaaaagct gggagattca ttaagtgttg atacgtcttt gaaccgggaa
    10441 gacagtttct taaaaaatta caaaaaaagt tccgcaaaag gataccagac aaaaaaggca
    10501 tatctgatcc gtggagaaaa gttaagaccg ggcgagttcg gcgtgatgca cggttatatg
    10561 aaaataccgg agttgaaacg ggtctgtcat gcgatggaaa tcagtatcaa cgaatatctg
    10621 gtaagtgtgt acatctggag cgtttataca gaatgtctgc acggcatgcc gtcaaagtgt
    10681 ccgatccgtg ttgcggtgcc ggttaatctg cggccgtatt ttaattctat taccacgaaa
    10741 aacttttttg tcatggtgtc cgcagaattt catccgacca aagagaccta tacgtttgca
    10801 gaggtggctg caatcgtgaa ggaaagcctg cgaagccaga tcaaccggga aaatcttgaa
    10861 aagctgtttt cctataacgt ttccaatgaa aaactgctga ttgcaagagt tgtgccgctt
    10921 ttcctgaaaa accttgcaat gaagtatgta tatacaactt ctgcacttgc caatactgcg
    10981 acgatcacaa atatcggcaa tatttccgtg acagaagagt accgccctta tgtggaaatg
    11041 tttcatgcat ttcttgccat gtcaaagggg cagcatctga aaggaacgat ctgctcttac
    11101 ggggatacac ttgtattcag tttcagttat gatcttgtcg atgcgtctgt gcagcgtgga
    11161 tttttccgga aaatagcctc ggacgggatt gcggtagaaa taaagagtaa tggagtaaat
    11221 tatgagtaaa tgcagaaatt gtaatgtgga gatatcagat gaaacagagc gctgtccact
    11281 ctgcggatcc gtgttagaat acacaggtga agtggagaat atgtacccgg atgtgagagt
    11341 gcacacccgg aaaatgacaa tgatcagtaa aatctatctg ttttgtgcac ttttggttga
    11401 ggtgctgctc atttatatca atgtggtcac cgagtcacag attgcatgga gtgcgatcac
    11461 ggggcttgga ttcttttacg gatatatgct gatccgtttt gcaattcttg gaaagacagg
    11521 ttaccgcgcc aaaatcacgg tactcacgct gatggcgata ctgatcgtga tcgcaatcga
    11581 ttttctggtc ggctaccgcg gatggtctgt caattatgca ttgccgtcgg cgatcatttt
    11641 agtcgatgtt ggtattatca tctgtatgat cgtaaaccgc agaaactggc agagctatat
    11701 gatgtggcag atttttatga ttttatgcag cattgttccg gtaatactga tttttaccgg
    11761 tatcgtgacg gcacagcttt ttgcactgat cgcatttgcg ttttccctgt ttctgtttct
    11821 tggaacactg atcatcggag accgcagggc aagggtggaa ctgaaacgaa gatttcatgt
    11881 ccgctgagtt atatttagaa taaaaagaac aggagcaatc ggatgagaga gagcgaagcg
    11941 agtatcaggg gaagagtcat gagggacctg atcgcccatg tgacaaatga tcacctgatt
    12001 gggaaaaaga taaaaaatgg agaactgagg aaaaaaatcg gggattcgga gccgccgtgg
    12061 aaatgtccgg actgtttttc attagatgtg atcgagatgg ataatttctc catggagtat
    12121 ttacaggcaa aagaaaatcc gaatacggaa aaagtaatct tacagcttca cgggggcgga
    12181 tatgtcggag cgatgcggaa tgcataccgt atgtttgccg gactttactg tgaagtcagc
    12241 catggaatga gtgttctgac acccgattac cgtgtggcac cggaacatcc gtatccggcg
    12301 gctttagaag atgcctatgc cgcatactgt tatctgttgg aacaggggtg gttttccgag
    12361 cagatcatca tcgcaggaga ttccgcagga ggcggtcttg cgatggcatt atgccattat
    12421 ctgaaagatc acggaaagca gcttccgtgt gggatcgtag ccatgtcacc gtggacagac
    12481 cttgcggcga gcggggaatc ttacgagaca aactttgagc gcgacccgtt atttggaaaa
    12541 acaagggaca gccttattta taataaagat tatattgggg ataacgatcc gtataatgct
    12601 tatatttcgc ctttatatgg ggatttcagg ggatttccgc cgatgctgat acaggttggt
    12661 tcctatgaga tgctgctctc ggattctgtg gatgtggctg caaaagccag agaacaggga
    12721 gtaaaagtaa gaatcagtat ttatgaagga atgttccaca tctttcagat ggcagcaaaa
    12781 atgctgccgg aatctaaaag agcgtgggtt gagatcggta aatttattga tgttttgcta
    12841 aatgactgac atccatatag acagggatac cgttttcgta ttttaccgga acttcaccga
    12901 gtatgagagg tgaaaggtaa tcgatcagtg gctgtgtgac atcattgcct gcatcgttga
    12961 tccattctct cggaattgat tttgcctcat ttgcaatgtg gcggatctcg gcatgctcat
    13021 aggcgatttc gtacggagca tcggagatac ggcgcattgt taccatggaa gcggtaacac
    13081 cttcctcgga gagagcaacc gctttctgac cgagagtaaa agcctcatca agatcagtct
    13141 ttgaagcaag gtgtgcagcg cagcgctgta atacgttgac ttccacggaa cggactttaa
    13201 cgcctagttt ttctttgact aaaaattcaa gtgtttttcc ggctccgctt aactggctgt
    13261 gaccaaaggt gtcaacagaa ctttcggaag cactgatata gttgccggaa gcatcgcgga
    13321 taccttcgga tacggcaacg atcacgttat tgcgctcgaa aagcatacgc tttacatcca
    13381 gtaaaaagtc ctctttgtca aatggaacct ccgggagata gatcagatgt ggtgctgtat
    13441 tataaccgtt tcttgccagt gcagaagcag cggtcagcca tccggcatca cgtcccatga
    13501 tttccacgat cgtcacactt ttgactgcat agataaatgt gtcatgtgcg atttctaaaa
    13561 gagaagatgc gatatatttt gcggcagaac cgaatcctgg tgtatggtct gtctcacaga
    13621 gatcattgtc gatggtcttt ggaataccga caatacgcac cggactgccg atttttttgc
    13681 catattcgga gagctttaag acggtgtcca tagaatcgtt gccgccgata taaaagaaag
    13741 catcaatatg gtaagtttca aactgtttga aaatgaatac ataggaagaa tcatcatcta
    13801 aataatttgg cagtttgtaa cggcaggagc caagatacat tgccggagtg acctttaagc
    13861 ggtcgagata ttccgaattc tgctgcatta attcagaaag attcgtcaga tcgttgttta
    13921 aaatacctg
//
