LOCUS       c00023_gnlPro..        14310 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BMGDPBIK_23.
ACCESSION   c00023_gnlPro..
VERSION     c00023_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:59:15
            Original ID  :: gnl|Prokka|BMGDPBIK_23
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14310
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14310
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[53:4310](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(54..4310)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14310
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14310
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(54..4310)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_1"
                     /sec_met_domain="HGD-D (E-value: 6e-60, bitscore: 194.4,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 3.4e-38, bitscore:
                     122.4, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENNTLHKLGIDIGSTTVKVAVLDEHDNLLFSDYERHFANIRETL
                     SSLIQKAFDQLGDRKVAPMITGSGGLTLAKHLDVPFVQEVISVSTALQHYAPQTDVAIE
                     LGGEDAKIIYFEGGNVEQRMNGICAGGTGSFIDQMASLIQTDASGLNEYAKNYKAIYPI
                     AARCGVFAKTDIQPLINEGATREDLSASIFQAVVNQTISGLACGKPIRGHVAFLGGPLH
                     FLSELKVAFIRTLNLDDEHAITPDNSHLYAAIGSALNCKPEQNTTLSSMLEKLNSDIHM
                     EFEVARLDPLFKDQAEYDTFRARHDGHNVKTGDLSTYEGNCYLGIDAGSTTTKIALVGE
                     DGSLLYSFYSNNNGSPLSTAIRSIKEIYEKLPANAHIVHSCSTGYGEALLKAALMLDDG
                     EVETVAHYYAAAFFDPEVDCILDIGGQDMKCIKIKNQTVDSVQLNEACSSGCGSFIETF
                     AKSLNFSVQDFAKEALFAKNPIDLGTRCTVFMNSKVKQAQKEGASVADISAGLAYSVIK
                     NALFKVIKLSDASELGKNIVVQGGTFYNDAVLRSFEKISGCECVRPDIAGIMGAFGAAL
                     IARERHEADYQTTMLSIDEINALTFDTKLARCQGCTNHCLLTINRFSGNRQYITGNRCE
                     RGVGGVKNKENIPNLFEYKNKRLFDYPSLKPEEALRGTVGIPRVLNMYENFPFWATFFK
                     KLGFSVVLSPQSTRKIYELGIDSIPSESECYPAKLAHGHVTWLIHQNVDFIFYPCVPYE
                     RNEFPDSNNHYNCPIVTSYAENIKNNVEDITSGKVRFYNPFMAFTSEETLSSQLVKTFG
                     APEFAIPESEIRDAVSEGYKELAVVRMEMQKKGEEVLAYMEKTGKRGIVLAGRPYHVDP
                     EINHGIPELINSYGIAVLTEDSVSHLHQVERPLIVMDQWMYHSRLYAAANFVKTRDDLD
                     LIQLNSFGCGLDAVTTDAVNDILTKSGKIYTCLKIDEVNNLGAARIRIRSLLSAIRVRE
                     KKQTKRTIIPSNYNRVVFTEEMRKNYTILCPQMSPIHFELLEPAFCAAGYNLVVPDVPS
                     RTCVDVGLKYVNNDACYPSLIVVGQLMSAVMSGNYDMNKTAILISQTGGGCRASNYIGF
                     IRRALEKAGYPNVPVISINLSGLESNPGFKLTPSLIQHGLYALEFGDIFLRCLYRTRPY
                     EAVKGSANALHEKWKKEVISFITQDKLLSHRKFKQMCRQIIRDFDNLDRVDVKKPRVGV
                     VGEILVKFHPAANNDLVGLLESEGAEAVVPDLTDFLLYCFYNTGFKADNLGFSKKSKRI
                     GRLGINFFEWLRSAARDEFEKSKHFDPPAHIDDLANYARDIVSEGNQTGEGWFLTGEMM
                     ELIHSGTPNIVCTQPFACLPNHVVGKGVIKELRHRFPESNIVAIDYDPGASEVNQLNRI
                     KLMLSTANKNLAKQSL"
     CDS             4565..5446
                     /locus_tag="ctg23_2"
                     /transl_table=11
                     /translation="MNWLNKLERKIGRYAVPNLIIWLIGAYTIGYVFGTVSPGILSYLT
                     LSPYHILHGQIWRLVTWVFMPTESNLIFLLIMALFYYQLGMALERTWGTFRFNVYIFGG
                     MIFTVIGAFVLYGIYYAMNASVISQMPALAAQLSYSIASGFSTNYINMSIFLAFAVMYP
                     DMQVMLYFIIPIKMKWMAIVYAVLTLYEFIVSGWAGRVAIFMSLLNFIIFFFSTRNFKR
                     YSPHEIHRRQQFKSQMRQPRPGSGITRHKCAICGRTELDDPNLEFRFCSKCDGNYEYCQ
                     DHLFTHKHIKKG"
     CDS             5584..6456
                     /locus_tag="ctg23_3"
                     /transl_table=11
                     /translation="MIQDIFPMHLSNEYHKKVPQADSFLMIFKDNYILAKNDGQVCYLT
                     YKELSEICRWMGKEIPVCVYLFSIGEDDYFLTDPGEGIEVPGFVYYKMFETRTMQPKER
                     VLAAATAWHLYVWYRDNVYCGRCGHKLVHSEKLRMLSCPDCNNMVFPKIAPAVIVGVTN
                     GRKILMTKYANREYKRYALIAGFTEIGETAEETVAREVKEEVGLSVKNIRYYKSQPWGF
                     DSNLLLGYFCELDDEGDAMRLDEEELACAEWVDFEDVPDDSEGLSLTREMMLCFRDIMN
                     ASESTCLHD"
     CDS             6736..8154
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_4"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 1e-10, bitscore:
                     32.2, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDKTKPKKGKKKVVIIVLVVLVVVAAIIGSSVKKMTSQVATAVN
                     TVEVEPVQKRDLSDTISLKGTVSGITKNNATSKALAEITAVNVQVGDIVKEGDVLCTLD
                     SSTIQDQIADLEKNMSDTNATDSINSQQTAETVSRAKEDQQTQLAAAQKAIDDAKDAYN
                     AQSIMWDKSEDKSDAEFQSLLAAQKAVTTAEEDYQKVLETTNRAIADAQLAVELDKYKT
                     TDSTSKDKLTDLKEQLADCNITAPCGGVVTAVNVSVGDVNADSKTALVTIEDTSSLKMV
                     ATVEEADILKIEEGMKATVTADAMGDETINGTVTRVVRVKGQSTGSDGQTTSGGYSVEI
                     SLDNKELLVGMEVKAKVMIKEKGEVLAIPYDLVKTDDDGNTYVLVAEANADGSATAVKK
                     NITVGEEVDYYTEVTGGDLAEGDKLIYDYSGTVTEGQQFTPEQMYSEQDMGTGASTDET
                     SDAEGMSTSVEGNE"
     CDS             8154..8663
                     /locus_tag="ctg23_5"
                     /transl_table=11
                     /translation="VSEPVIRMENIVKTYYLGKPNELEILHGINLTVNKGEFVSIVGES
                     GSGKSTLMNIIGVLDRQTQGNYYLEGQDVNGMSDEVRSAIRNRRIGFVFQNFNLLPRAN
                     ALKNVMXXXXCYGSITIWRGTFQKRKRTCHGNAQNGRNGRPCGSQTKRTFRWSETACCD
                     RPCHDQ"
     CDS             8653..8871
                     /locus_tag="ctg23_6"
                     /transl_table=11
                     /translation="MINDPAIILADEPTGALDSKTGHMVMDLFHKLHEEQGKTIVLITH
                     SQELAQETERIVTLLDGQIVADNGGEH"
     CDS             8871..10199
                     /locus_tag="ctg23_7"
                     /transl_table=11
                     /translation="MFWENIKEAVTSISSNKMRSLLTMLGIIIGISSVIIITTIGGSIQ
                     STLTATMNSLGGNMVQAYVEARYPENDEDWATWEQPEMTDSDYVTQDMIDGLIEKYPDE
                     VTGVAAQNYLGSGTIKDDADSKNYANVNIDGITPEYLEYMKLEMHAGRNLTKADNQGKK
                     RVCLIADTMAERYFAGKDPIGETLSVATSDGGIFDFVVVGVYVYNQALFGKVDTSIPEK
                     DRVTELMIPLQTCFKLQGTDRTGYDYFNLMIDPLADVNQATTDVLSYFDEMYANNKNFH
                     VSAYNMASDLGMINTVLNVITIAVSGIAAISLIVGGVGVMNIMLVSITERTREIGVRMA
                     LGAKRRTIRMQFVIEAIMLCLIGGIIGILIGIGIGALLGKVAGFVIQNMYSQYANYIIM
                     TVHPSVTAIMLSLFFSMLTGVFFGYYPANKASKMEVIDALRYE"
     CDS             10321..10779
                     /locus_tag="ctg23_8"
                     /transl_table=11
                     /translation="MMSNKNITKSNCFIFHDVGVKTINNFVIIRNIKFCDDSVGIIDTY
                     ISEKYDNIIEKNAVVHGKKIKHGDFLIEFLRDCGYNGQIYASYSNLKNSIDYPAMYQNV
                     IGCGYAKGELNKAIDNMYKSNRIIVWNNGLAYYKGNSYLSLYTMLKKV"
     CDS             10820..11065
                     /locus_tag="ctg23_9"
                     /transl_table=11
                     /translation="LQEYQEQFDIWINQPEQEKKYQATIMETGEKALSNHLFLRWIYPE
                     GLTEMSGSLFFIQGSIFPGMVHAPSHIEYKKKYCKV"
     CDS             11075..11956
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_deac_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_10"
                     /sec_met_domain="Polysacc_deac_1 (E-value: 1e-35, bitscore:
                     113.2, seeds: 80, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAMRRCYAISIIGMEGKNMNHNKKKILKVTALFVFMFFLGWGAG
                     SLQKQQMKKTVETVSVQNQADNWGLGFGAEGTQPTGNVTADELKKYNAWYVGDKSKNVI
                     YLTFDCGYENGNTEPILDALKKHNAKATFFVVGHFLESAPDIVKRMEAEGHAVGNHTYH
                     HPDMSSISDMTSFQKEMDDVASLYQTVTGKEMIKYYRPPQGKYSTKNLEMAKELGYHTF
                     FWSLAYVDWNVDDQPTKEEAFDKLLTRIHPGAIVLLHSTSKTNGEILDELLTKWEEMGY
                     TFAPLSELIEES"
ORIGIN
        1 ctataagcgc ggctgtgaaa acggtaatgc atgatgataa atctgtgtgt gatttataaa
       61 gattgctttg caagattttt gtttgcagtt gagagcatca gtttgatacg gttcaactgg
      121 tttacttcac ttgcacccgg atcgtagtca atggcaacga tatttgattc cgggaaacgg
      181 tggcgcagct ctttgataac accttttcct acaacgtggt tcggcaggca ggcaaatggc
      241 tgtgtacaga cgatgtttgg tgtaccactg tggatcagct ccatcatctc gccggttaag
      301 aaccatcctt caccggtctg gttaccttcg gatacgatat ctcttgcata atttgcaaga
      361 tcgtcgatat gagcaggcgg atcaaaatgc ttactctttt caaattcatc tctggcagcg
      421 cttcttaacc attcaaagaa attgatgcca agtcgtccaa tgcgtttgga ctttttgctg
      481 aaaccgaggt tgtcagcctt aaatccggtg ttatagaagc agtagagcag gaagtcggtc
      541 agatccggca cgacagcttc tgcgccttcg gattctaaca atccgactaa atcgttgttt
      601 gcagcaggat ggaattttac taagatctct ccaacgacgc cgacacgcgg ttttttcaca
      661 tctacacggt caaggttgtc aaaatcgcgg atgatctgac ggcacatctg cttaaatttg
      721 cggtgggaca acagtttatc ttgtgtgata aaggagatta cttctttttt ccatttctca
      781 tgcagtgcat tcgcagatcc ttttactgct tcataaggac gtgtgcggta cagacagcga
      841 aggaaaatat cgccaaactc taatgcatat agtccgtgct ggatcagtga aggcgttagt
      901 ttaaagccag gattgctttc aagtccgctt aagttgatgg agattaccgg tacattcgga
      961 tatcctgctt tttcaagagc acgacggata aaaccgatgt agttgctggc acgacagcct
     1021 ccgccggtct gcgagatcag gatcgcggtt ttgttcatgt cataatttcc ggacataaca
     1081 gcactcataa gctgtccgac cacaatcagt gacggatagc aggcatcatt atttacatat
     1141 tttaatccga catccacaca ggtgcggctt ggaacatccg gtaccaccag gttataaccg
     1201 gctgcacaga atgcaggttc taacagctca aagtggatcg gtgacatctg cggacagaga
     1261 attgtataat ttttacgcat ttcttccgtg aaaacaactc tgttatagtt ggaaggaata
     1321 attgtccgtt ttgtctgttt cttctcacgg acacggatgg cggagagcag ggaacggata
     1381 cgaatccttg cagcacctaa gttgttaacc tcatcaatct ttaagcatgt gtagatcttg
     1441 cctgattttg tcaggatgtc gttgactgcg tcggtggtaa ctgcgtctaa gccacaaccg
     1501 aaggagttca actggatcag atcaaggtca tccctggttt ttacaaagtt tgcagccgca
     1561 tacagacggg aatgatacat ccactgatcc ataacgatca gagggcgttc cacttgatga
     1621 aggtgagaaa cggagtcctc agtcagtacg gcaataccat aggaattgat cagttccggg
     1681 ataccgtggt tgatctcagg gtcaacatgg tatggacgtc ctgctaatac aataccgcgt
     1741 ttgccggttt tctccatata agctaagact tcttcacctt ttttctgcat ttccatgcgg
     1801 acaacagcaa gttctttgta accttcggaa acagcgtcac ggatctctga ttccgggatg
     1861 gcaaattccg gtgcaccaaa ggtttttaca agctgggaag ataaagtttc ttcgctggta
     1921 aatgccatga atggattata aaaacgtacc ttgccggaag tgatatcttc cacgttattt
     1981 ttgatatttt ccgcgtagga ggttacgatc gggcagttgt aatggttgtt ggaatccgga
     2041 aattcattgc gctcataagg tacacatggg tagaaaataa agtctacatt ctgatggatc
     2101 agccaggtca catgtccatg tgcaagtttt gccggataac actcggattc acttggaatt
     2161 gagtcaatgc cgagctcata gatttttctg gtggactgtg gtgacagtac aacggaaaat
     2221 ccgagttttt tgaaaaaggt agcccagaac gggaaattct cgtacatatt taaaactctt
     2281 gggataccta ctgttccacg cagggcttct tccggcttta aggaagggta gtcgaataag
     2341 cgtttattct tgtattcaaa taagttcgga atattttctt tgttttttac gccgccgaca
     2401 ccgcgctcac agcggtttcc cgtgatatac tggcggtttc cggagaaacg gttgatcgtc
     2461 agcagacagt ggttggtaca accctgacat cttgcaagtt tggtatcaaa agttaatgca
     2521 ttgatctcgt cgatggaaag catcgttgtc tgatagtcag cttcatgtcg ttctcttgcg
     2581 atgagagcag ctccgaaagc acccatgata cctgcgatat ccggacggac acattcacag
     2641 ccggaaatct tttcaaaact gcggagcacg gcatcattgt aaaaagtacc accctgtacg
     2701 acgatatttt ttccgagctc acttgcatcg gagagtttga taaccttaaa taaagcattt
     2761 ttaatgacgg agtaggcaag tccggcagag atatctgcta cggaagctcc ttctttctgt
     2821 gcctgcttta ctttagagtt catgaataca gtacagcgtg ttccaagatc aatcgggttt
     2881 ttggcaaata aagcttcttt tgcgaagtcc tgtacagaaa agtttaagga ttttgcaaat
     2941 gtttcgataa aagaaccaca gccggaagaa caggcttcgt ttaactggac actgtctacc
     3001 gtctggttct tgatcttgat acatttcata tcctgaccac cgatgtctaa gatacagtct
     3061 acctcaggat caaaaaatgc cgctgcataa taatgtgcta ccgtttctac ttcaccatcg
     3121 tctaacatca gcgctgcttt taagagagct tcaccgtaac cggtagagca ggagtgtacg
     3181 atatgtgcat ttgccggaag tttttcatag atctccttga tggaacggat cgcagtggaa
     3241 agcgggcttc cgttgttgtt gctgtaaaat gaatacaaca gggaaccgtc ctcgccgacg
     3301 agagcgatct ttgttgttgt ggaaccggcg tcgataccga gataacagtt gccttcgtag
     3361 gtggaaagat cacctgtctt tacattgtgt ccgtcgtggc gggcacggaa ggtatcgtat
     3421 tctgcctgat ctttaaataa cggatcaaga cgtgctacct cgaattccat atgtatatca
     3481 gagtttaatt tctcaagcat ggaagagaga gtggtattct gttccggttt gcagtttaag
     3541 gcagaaccga tcgctgcata aaggtgcgaa ttgtccggcg tgatcgcatg ctcatcatct
     3601 aagtttaagg tgcggataaa tgcaactttt aactcagata aaaagtggag cggaccacct
     3661 aagaatgcaa cgtggccgcg gatcggctta ccacaggcaa gaccactgat cgtctggttt
     3721 accaccgcct ggaaaataga agcagagaga tcctctcttg tggcaccttc gttgatcaga
     3781 ggctggatgt ctgttttggc aaaaacaccg cagcgggctg caatcgggta gattgctttg
     3841 taatttttcg catattcatt cagaccggag gcatctgtct gaatcaggga agccatctgg
     3901 tcaataaaag aaccggtacc gcctgcgcag ataccgttca tacgctgttc aacgttaccg
     3961 ccctcaaaat aaataatttt tgcgtcttca ccgccgagct cgatcgcaac gtctgtctgt
     4021 ggagcatagt gctgtaaggc ggtagacaca gagataactt cctgtacgaa aggaacatct
     4081 aagtgctttg caagtgtaag tccgccggaa ccggtgatca ttggagcaac cttccggtca
     4141 ccgagctgat cgaatgcttt ctggatcaga gaagaaagcg tttcccgtat gttggcaaaa
     4201 tgcctttcat aatcggaaaa gagcagattg tcatgctcgt cgagcacagc aacctttacg
     4261 gtggtagaac cgatatcaat tccaagtttg tgaagcgtat tattttccat aatttcctcc
     4321 agtcagtaac tccggaaaat ccggataata tataaataaa gtggctgttt cttcttatta
     4381 aaaagaatgc cgggcaaaag ccaagcaaag tacattatac gacatgattt tacaaaagac
     4441 aatgtgcaaa tcggggaaaa atataaactt tttatgaata aaatcagcct ggattgacaa
     4501 agcacaggca tacggatata ctgaaaaaag tagtgttttc aaagaaaggt tagggtttta
     4561 tccgatgaac tggttaaata aattagaacg taaaattggt cgttacgctg ttccaaacct
     4621 tattatatgg ctgatcggag cctatacgat cggctatgta ttcggaaccg tatcgcctgg
     4681 tattttaagc tatctgacac tcagtcccta tcatatttta catggacaga tctggagact
     4741 ggtgacatgg gtgtttatgc cgacagagtc caatctgatc ttcttactga tcatggcatt
     4801 gttttattac cagcttggca tggcactgga acgtacctgg ggaaccttcc ggtttaatgt
     4861 ctatattttc ggtggaatga tatttaccgt gatcggtgca tttgttctgt acggtattta
     4921 ttatgcaatg aatgcatctg taatttcgca gatgcctgca ctggcggcac agttatctta
     4981 ttcgattgcg tcgggatttt ccacaaacta tatcaatatg tccatttttc ttgcatttgc
     5041 cgtgatgtat ccggatatgc aggtaatgct ttacttcatt atcccaatca agatgaaatg
     5101 gatggcgatt gtttatgcgg tactgacgct ttatgagttt attgtcagtg gatgggccgg
     5161 cagagtggca atctttatgt ccctgctcaa ttttatcatt ttcttctttt caacgcggaa
     5221 tttcaaacgt tattcgccgc atgaaataca caggagacag cagttcaagt cccagatgcg
     5281 tcaacccaga ccgggttccg gcattaccag gcacaaatgt gcgatttgtg gcaggacaga
     5341 acttgatgat ccgaatttag agttccgttt ctgttcaaag tgtgacggca attatgaata
     5401 ttgccaggat catctgttta cacataaaca tattaaaaaa ggttaaataa tatgacaggc
     5461 cggatggtat ttcaaagcga aatatcatcc gttttttgaa tgatggcaca aagaagatta
     5521 gattttaggt gtgatttgtt tcaggttctg tcagaataaa tgcagataaa ggagaaaaat
     5581 acaatgattc aggatatatt tccgatgcat cttagtaatg aatatcacaa aaaggtacca
     5641 caggcagaca gttttcttat gatctttaaa gataactata ttctggcaaa aaatgatggt
     5701 caggtgtgtt atctgaccta taaagaactt tctgaaatct gtcgttggat gggaaaggaa
     5761 atccctgtat gcgtttatct tttttccatc ggggaggatg attattttct gacagatccg
     5821 ggggaaggga tagaggtgcc gggatttgta tactataaaa tgtttgagac acgcaccatg
     5881 cagccgaaag agcgggtgct tgcagctgcg accgcatggc atctgtatgt ctggtaccgc
     5941 gataatgttt attgtgggag atgtgggcat aaactggtac atagtgaaaa actccggatg
     6001 ctttcatgtc cggactgtaa caacatggtt ttcccgaaaa tagcaccggc agtgatcgtg
     6061 ggcgtgacaa acggcagaaa aatcctcatg acaaaatatg caaaccgtga atataaaaga
     6121 tatgcactga ttgccggatt taccgaaatc ggtgaaactg cggaggaaac ggtggcgagg
     6181 gaagtgaagg aagaggttgg gctttccgta aaaaatatcc gttattacaa gagtcagcct
     6241 tggggatttg acagcaatct tcttcttggc tatttttgtg aactggatga tgagggagat
     6301 gcgatgagac tggatgagga ggaacttgcc tgcgcagaat gggttgattt tgaggatgtc
     6361 ccggatgatt cggagggact tagtctgaca cgggaaatga tgctctgttt ccgggatata
     6421 atgaacgcaa gtgagtcaac atgcttgcat gattgacgaa cggtgaattg gatcatgtga
     6481 cggttttgca catgatacga tgaaagaata cggtagattc taaaagacag ggaaaactgg
     6541 tatgcaaaat tataccaaat acgaaaaatg tcttgacact ccaacaaaac tactgtatta
     6601 ttacagtaat acaaaaaaga aagatttacg gatggaaaac ttaagatttc ttaatatttg
     6661 cttaagtgcc tttttttggc aaatggataa tgatacaatc accgtaaatc gaattaagaa
     6721 aagggagaaa taaaaatggg tgacaagaca aaaccgaaaa agggaaagaa aaaagtagtt
     6781 attattgtgc ttgtggttct ggtcgttgta gctgcgatca ttggaagttc agtaaagaaa
     6841 atgacaagcc aggtagcaac agcagtcaat acagtagagg tggagccggt acagaagaga
     6901 gatttatctg atacgatttc attaaaaggt actgtatcgg gtatcacgaa gaataatgca
     6961 acttcaaaag cgttagcaga aatcacagca gttaatgttc aggtcggaga tattgtaaaa
     7021 gagggagatg tattatgtac attagattcc tctacgattc aggatcagat tgcggatctc
     7081 gaaaaaaata tgtctgatac aaatgcgaca gacagtatta attcacagca gacagcagaa
     7141 acagtcagtc gtgcaaaaga agatcagcag acacagctag cagctgcaca gaaagcaatt
     7201 gatgatgcaa aggatgctta taacgcacag agtattatgt gggataagag tgaagataaa
     7261 tcggatgcag aatttcagtc tttgttagct gcacagaaag cagttactac tgctgaggaa
     7321 gattaccaga aagttcttga gactacaaac cgtgcgattg cggacgcaca gcttgccgta
     7381 gaactggaca aatataaaac aacagattcg acatccaaag ataaactgac agatttaaaa
     7441 gaacagttag cagattgtaa catcacagca ccttgcggcg gggttgtgac ggcggtcaat
     7501 gtttctgtcg gcgatgtcaa tgcagattct aaaacagcac ttgtaacaat tgaggatacc
     7561 agttctttaa aaatggttgc aactgtggaa gaagccgata ttttaaagat tgaagaggga
     7621 atgaaagcaa ctgtaacagc ggatgccatg ggagatgaga ccattaatgg aactgtgacc
     7681 agagtggtac gtgtcaaagg acagtccacg ggatctgacg gacagacaac atccggagga
     7741 tattccgtag agatatcttt agataacaaa gaattacttg tcggtatgga agtaaaagca
     7801 aaagtcatga tcaaggaaaa aggtgaagta ttagcgattc cttatgatct tgtcaagacg
     7861 gatgatgacg gaaatacata cgtacttgtt gcagaggcaa atgcagacgg ttctgctaca
     7921 gcggtgaaga agaatatcac agttggtgaa gaagtagatt actatacgga agtaaccggt
     7981 ggagatctgg cagaaggaga taaattaatt tatgattact ccggaacggt gacagaagga
     8041 cagcagttta caccggaaca gatgtattcc gagcaggata tgggaacagg cgcatctaca
     8101 gatgaaacct cagatgcaga aggtatgagc accagcgtgg agggaaatga gtagtgagtg
     8161 aaccagtaat ccgaatggaa aatatcgtta agacatatta tttgggaaaa ccaaatgaac
     8221 ttgaaatttt acatggaatc aaccttaccg taaataaagg ggaatttgtt tccatcgtcg
     8281 gtgaatccgg ttccggtaag agtacactta tgaatattat aggagtcctc gaccgccaga
     8341 cacagggaaa ttattatctg gagggacagg atgtcaatgg aatgtcggat gaagtacgga
     8401 gtgcgatcag aaaccgcagg attggttttg tatttcagaa ctttaatctc cttccgagag
     8461 ccaatgcatt aaaaaatgtt atggnnnnnn nnnnatgtta tggttccatt actatatgga
     8521 gaggaacatt ccaaaaacgg aaaagaacat gccatggaaa tgctcaaaat ggtaggaatg
     8581 gaagaccgtg cggatcacag accaaacgaa ctttccggtg gtcagaaaca gcgtgttgcg
     8641 atcgcccgtg ccatgatcaa tgatccggcg atcattcttg cggatgagcc gaccggagca
     8701 cttgattcta agacaggtca tatggtcatg gacttattcc ataagcttca tgaggagcag
     8761 ggaaaaacaa ttgttctgat cacacactcc caggaacttg cgcaggagac agagcgtatc
     8821 gttactctgt tagatggaca gatcgtggca gataatggag gtgagcatta atgttttggg
     8881 aaaatatcaa agaggcggtc acgagtattt ccagcaataa gatgcgttcc ctgttaacaa
     8941 tgctcggaat catcatcggt atcagctcag tgatcattat cacaacgatc ggtggttcca
     9001 tacagagtac actgacggca accatgaatt cccttggcgg aaatatggta caggcgtatg
     9061 tggaagcacg ttatccggaa aatgatgagg actgggctac ctgggaacag ccggagatga
     9121 cagacagtga ttatgttaca caggatatga tcgatggatt gattgaaaaa tatccggatg
     9181 aggtaacagg tgttgcagca cagaactatc ttggttcagg aaccattaaa gatgatgctg
     9241 attccaagaa ttatgcaaat gtcaatattg atggtatcac accggaatat ttagagtata
     9301 tgaaactgga aatgcatgcc ggaagaaatc tgacaaaggc agataatcag gggaaaaaga
     9361 gagtatgcct gattgcagat acgatggcag agagatattt tgcaggtaaa gatccgatcg
     9421 gtgaaacact ttctgttgca acatcggatg gcggaatttt tgattttgtt gtagttggcg
     9481 tttatgtata taaccaagca ttatttggaa aagtggacac gtccataccg gaaaaagacc
     9541 gtgtaacaga attgatgatc cctcttcaga cctgttttaa actgcagggg actgacagga
     9601 ctggttatga ttattttaat cttatgatcg atcctcttgc agatgtcaat caggcaacaa
     9661 cggatgtttt atcttatttt gatgagatgt atgcaaacaa caaaaatttc cacgtcagtg
     9721 catacaatat ggcatctgat cttggcatga tcaatacggt actcaacgtg atcacgatcg
     9781 cggtttccgg tattgcagcg atttcactga tcgtgggtgg tgtcggcgtt atgaatatca
     9841 tgctggtgtc catcacggag cgtacaagag agatcggtgt ccgtatggcg cttggtgcca
     9901 aaagacgtac catccgtatg cagtttgtca tagaggcgat catgctttgt ctgatcggag
     9961 gtatcatcgg tatactgatt ggtataggaa tcggggcact gcttggaaaa gtggcaggat
    10021 ttgtcattca gaatatgtac tctcaatatg caaattatat tattatgacg gtgcatcctt
    10081 ctgtaacggc gatcatgctt tcactgttct tctctatgct gaccggtgta tttttcggat
    10141 attacccggc gaacaaggct tcaaagatgg aagtcatcga tgcattgcgc tatgagtaag
    10201 ggcaaagaaa agatttgcat tgcagtctga gcagagaatt tttaaaagaa tacagataag
    10261 aaaagtattg tatgtgacaa aaataaaaat gtcagtatac aatacttttt tgtttatgtg
    10321 atgatgtcta ataaaaatat tactaaaagt aattgtttta tatttcatga tgttggggtc
    10381 aaaaccataa ataattttgt cataataaga aatataaaat tttgtgatga tagcgttggc
    10441 ataatagata catatataag tgaaaaatat gataatataa ttgaaaaaaa tgctgtggta
    10501 catggtaaga aaataaaaca tggagatttc ttaattgaat ttttaagaga ttgcggatat
    10561 aatgggcaaa tatatgcaag ttattcaaat ttaaaaaatt ctattgatta tccggctatg
    10621 tatcagaatg taataggttg tggatatgca aaaggtgaat tgaataaggc aattgataat
    10681 atgtataaaa gtaacaggat tatagtttgg aataatggat tagcttatta caaaggaaat
    10741 tcttatttat cgttgtatac aatgttaaaa aaggtgtaaa aacggtggat atttatgtcc
    10801 tgattatgta gcagaaaatt tgcaggaata tcaggaacaa ttcgatatat ggattaatca
    10861 gcctgaacag gaaaaaaaat atcaggctac aataatggaa accggagaaa aagcgttatc
    10921 caaccattta tttttaagat ggatttaccc ggagggcctg acagaaatgt caggctcttt
    10981 gttttttata cagggatcaa tatttccggg catggtacat gcgccttccc acatagaata
    11041 caaaaagaaa tattgtaaag tatagcattc atgcatgata gcgatgcgta gatgttatgc
    11101 aatatcaata atcgggatgg aagggaaaaa catgaaccat aacaaaaaga aaattttaaa
    11161 agtgacggca ctgtttgttt ttatgttctt tttaggctgg ggcgcaggtt cgctgcagaa
    11221 acagcagatg aaaaaaacag tggagacagt gtctgtccag aatcaggcag ataactgggg
    11281 actgggcttt ggagcggagg gaacccagcc gaccggcaat gtgacggcag atgaattaaa
    11341 aaaatacaac gcatggtatg tgggagataa aagtaaaaat gttatttatc tgacatttga
    11401 ctgcggctat gaaaatggaa atacagagcc gattttggat gctttaaaaa agcataatgc
    11461 aaaagcgaca ttttttgttg tgggacattt tcttgagagt gcaccggata ttgtaaaacg
    11521 tatggaggca gaagggcatg ctgtcggcaa tcatacttat catcatccag atatgtcatc
    11581 aatatcagac atgacctcgt ttcagaaaga gatggatgat gtcgcgtcat tgtaccagac
    11641 agtcacaggc aaagaaatga taaaatatta ccgcccgcca cagggaaaat acagtacaaa
    11701 aaaccttgag atggcaaaag aacttggata ccatacattt ttctggagcc ttgcctatgt
    11761 ggactggaat gtggatgatc agccgacgaa ggaagaggca tttgataaat tgctgacgag
    11821 aatccatccg ggagcgatcg ttttattgca cagcacttca aagacgaatg gagagatttt
    11881 agatgagctg ctgacaaaat gggaagaaat gggatacaca tttgcgccgc tttcggagtt
    11941 gatcgaagaa tcctgacaga aaagattgtg gaaaaataca aaagatacaa gggataagac
    12001 ttgtttgatg acggagagga aggtataatg aacgtggagt gccagtgaga aagaagcggt
    12061 ttttagtctg ggtaaaatgc tgcatgataa actgggacgg tatgaaaaca atatttgata
    12121 cgagtaagaa tagggatgca tatgaaaaga acaaaattta aaacaggaat attggcggtg
    12181 gttttttgca gtctgacatt tttgttttcc ggggatggta acagcattta tgcggatgaa
    12241 attctgacag atacagaatt accggtcggt cgtttttcgt ttgaagaaaa aacagaagaa
    12301 gcagatgatg aggattatga gtctgtagag gaagatgacg ttgcggaaca gtcattgctt
    12361 cggatgacag gtatatctgc cgatgactgg gaaaagtatg gaagtgatta tttttatgaa
    12421 cagttatcgg atgaggaaaa aaaatactgg gatgatctgg atgccatatg tgcaaaatat
    12481 ctgacaacag aaacggatgc agtgacaacg aatacgggaa cgtaccggat gaaggcgata
    12541 tcgggaagca ctcttgaaaa agaaaagcaa aaaaaggtat tgcggatgtt tcggtattca
    12601 aaaccacaat attatttttt aaatgcgacg atttatacaa ttacatactc agacaaaaaa
    12661 gtttctatga tatttggtat ttatcctgca tttggcaagg gtgcagaccg gatggaggaa
    12721 actgaaaaag taaaagcgca ggttgacacc tggcagaaac agattgatga atgcagcaca
    12781 gaggacgaaa aagtacaaac catacatgat ctgatcattc aaaaggttga atataatcat
    12841 gatcttgtaa atagcgattt tgcaacagaa aatacagaat attcacagtc cgtatacagt
    12901 gttttatgta cgaataagac ggtatgtgca ggatatgccc agacatttga gatgatgtgc
    12961 aatggaaccg gtattgatac cgtggcagtg actagttttg aacatgagtg gaataagata
    13021 aagttggaaa atagctggta taatgtcgac tgtacctggg atgataacgg aagcgataac
    13081 gttggatata cctattttct gcggaatgat gattattatg acacatccag cagttattct
    13141 aaaaaacatc atgcggagga aagctattgg gaaggatatc tgcctgcaac agaaatggat
    13201 agtgttggca gtccatggat atctatgaac gaaaatgcaa gtggatcaaa gataggaatg
    13261 tcctgttata ataaggaggc agaaatctat tataccacgg ataaaagtaa tccggtgaca
    13321 tccggtacgc ggatgttata tcaatcggat tttttatgga acagctccga atatccggtg
    13381 ataaaagcag ctgccatgga agatggaaaa cacaacagtg ctgtggtcac aaaatgtctg
    13441 cataattaca atgcaagtat acttgcagat gcagcctgtg aaaaagccgg aacaagagag
    13501 tatacctgta cgatctgcgg aaatagttat atggaagaaa tcccagccac aggacataca
    13561 gttgagatag atcctgaggt ggcagctgct tgtgaaaccg ccggtattac ggaaggaagc
    13621 cattgccgtg tctgcggaaa agtactggtt gagcagactg tcatcccagc cacaggacat
    13681 acaccggtta cagatgacgc ggtagcggca gcttgtgaga caaccggact gacagaagga
    13741 agtcattgca gtgtctgtgg aaaagtactg acagaacaga ctgtcatccc ggctgcagga
    13801 catgtaccgg ttacggatgc tgcagtggag acagcttgtg agacaaccgg actgacagag
    13861 ggaaatcact gtagtgtttg tggaaaagtg ctgacggcac agaatgtgat ccccgcaacc
    13921 gggcatcaat ggaacgagta caaagaaagt ggaaaaataa aacgtaagtg cagtgtctgt
    13981 ggaaagacgg aaacggtggg cacttatttg gacgtaaaga aaatccagct ttcaaaaacc
    14041 acatatgctt atgatggaaa ggcacatatg ccgactataa aagtgacaaa tactgctgga
    14101 aagaagttaa aagagggaac ggattataaa ataaagaagc cgtccgggcg gaaaaatgcc
    14161 ggtatctata cggtcacgat tgaaatgaaa ggtgattaca ctggaaaata ccagaaaaca
    14221 tttcagatca taccgaaagg aaccgctatt tccggtgtaa aggcaaagaa aaaagcattt
    14281 tcggtgtcct ggaagaagca ggcaaaacag
//
