LOCUS       c00078_gnlPro..        13412 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PIJKPNMN_78.
ACCESSION   c00078_gnlPro..
VERSION     c00078_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 03:05:30
            Original ID  :: gnl|Prokka|PIJKPNMN_78
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13412
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13412
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1598:6886]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1599..6886
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13412
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13412
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(3..110)
                     /locus_tag="ctg78_1"
                     /transl_table=11
                     /translation="MKMQMEIRFKKCGISNQPDVCIFDDPCLSKFGALRG"
     CDS             295..1470
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_2"
                     /sec_met_domain="Peptidase_S11 (E-value: 2e-51, bitscore:
                     164.5, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLIFSPVRVRAQDVPAESELYAKSAVLMDADSGRILYEKNGHE
                     AMANASTTKILTCIVALENCDPASVVTVSKNAASQPKVHLGMHEGQQFYLRDLLYGLML
                     ESYNDCAVAIAEFAAGEVQGFAALMNAKAEELGCEDSYFITPNGLDAKDDAGFHHTTAA
                     DLAKIMKYCIKESLKSDEFLEITRTAQYSFSDAEGKCTYQCTNHNAFLQMMEGALSGKT
                     GFTGTAGYCYVGALQREDKTLIVALLACGWPNNKTYKWSDTRKLMNYGLEQFKKIDLLQ
                     IEPDEAELAPIEVRDGQGGKIGETVYLKPVVRNYAGEESILAPLSSEVTLKYEIADRLY
                     APVKSGEYIGKIRYMLGEETLAERCVVAGETIGKIDYPWCLGQVLRLLWIE"
     CDS             1599..3092
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_3"
                     /sec_met_domain="CT_Vparvula (E-value: 3.9e-125, bitscore:
                     408.0, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPHPKWMWTTIYRWRAKRMNSSNDSLAMQRITRLVDENSFIEIG
                     SLVTARSTDFNLAATDTPSDGVITGHGLIDGNLVFIYSQDASVLNGTIGEMHAKKIAAV
                     YDMAMKMGAPVIGFIDCAGVRLQESVDALDGFGLIYAKEVAASGVVPQISAVFGSCGGG
                     LAVVPALSDFAFIEESKGKMFVNSPNAIDGNRIEKCDTSSAAFQADENGCIDATGTEDE
                     ILTDIRELVGMLPLNNEGDVYTDECADDLNRACESMDAMKGDPRYLLSEISDSHTFFET
                     KAGYARDMVTGFIKLNGMTVGAVANCTTVYDEEGKESEKFDNVLSAKGCEKAAEFVSFC
                     DAFEIPVLTLTNVKGYKACKCSEKRLAKALAHLTSAFAGATCPKVNLITGEAYGTAYVA
                     MNSKSIGADFVYAWPDAKVGMMDADLAVKIMYADASADELAEKAKEYDALQGSVMTAAR
                     RGYVDLIVDPADTRKYLVDAFELLYTKCAYTPDKKHGTK"
     CDS             3079..3831
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_4"
                     /sec_met_domain="OAD_gamma (E-value: 5.3e-26, bitscore:
                     81.0, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQNRKVKFMKKKLSLILCLCFMALGLAACGTDPTTVDYFGMTYD
                     ELQSSMEQEVSALVGLTDDNRTYIQSYGSDTAMKLVESWDEATSDVGAYQGLGEFNITK
                     AQKTLTVDQYVEYQNREVIVSYIYTYNYETEQPELTDATADKVYTLGEKMEKAALNTLM
                     GMGTVFVVLILISLIIYCFRFISVIQNKAAGKGKKNEAEAGAVVEQIGQREEQLTDDLE
                     LVAVISAAVAASTGASADSFVVRSIRRR"
     CDS             3873..4238
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 61.7; E-value:
                     1.5e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_5"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.1e-20, bitscore:
                     61.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGNVYDVTVEENGAVSAPAAAPRRAAAPAAAPAAKPA
                     AAAGAGSVKIEAGAAGKVFKLEKSVGDAVKKGDSIMVLEIMKMETPVVATQDGTVASIN
                     VSVGDMVEAGALLATLN"
     CDS             4254..5402
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_6"
                     /sec_met_domain="OAD_beta (E-value: 2.9e-157, bitscore:
                     512.8, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYFSETMGNLLHQTAFFNLTWGNFVMIIVACFFLYLAIAKGFEP
                     LLLVPIAFGMLLVNIYPDIFADPEQMSNGVGGLFHYFYVLDEWSILPSLIFLGVGAMTD
                     FGPLIANPISFLLGAAAQFGIFGAYFLAIMMGFNDKAAAAVSIIGGADGPTSIFLAGKL
                     GQSGLMGPIAVAAYSYMALVPIIQPPIMKLFTTKKERAIKMENLRPVSKLEKILFPIVV
                     TVVVCTILPTTAPLVGMLMLGNLFRESGVVRQLTDTASNALMYIVVILLGTSVGASTSA
                     EAFLNTTTLKIVALGLIAFMFGTAAGVLFGKLLCFLTKGKINPLIGSAGVSAVPMAARV
                     SQKVGAEEDPTNFLLMHAMGPNVAGVIGTAVAAGVFMAIFGI"
     CDS             5468..6886
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_7"
                     /sec_met_domain="HMGL-like (E-value: 1e-45, bitscore:
                     146.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.3e-59, bitscore:
                     191.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVVKKPLKITETVLRDAHQSLIATRMTTEQMLPIVDKMDKVGY
                     NAVECWGGATFDACLRFLKEDPWDRLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSIANGIDIIRIFDCLNDVRNLQTAVTACNKEKGHAQVALSYTLGDAYTLDYWME
                     MAKKVEDMGADSLCIKDMAGLLVPTKATELIQALKSATNLPIELHTHYTSGVASMTYMK
                     AVEAGCDIIDTAMSPFSMGTSQPATEVMVEAFKGTEFDTGLDQNLLAEIADYFRPMREE
                     ALESGLMNPKVLGVNIKTLLYQVPGGMLSNLLSQLKEQGKEDKFEEVLAEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKVATKETKDVLLGKYGQTVKPFNPEIVDKVLGE
                     EKKNAITCRPADLLEPELDKIEAEMKQWKQQDEDVLSYALFPQVATEFFKYREAQQKKV
                     DASVADTKNGAYPV"
     CDS             7089..8765
                     /locus_tag="ctg78_8"
                     /transl_table=11
                     /translation="MRKKEDRLKTAAFVLSAGVFFGVCPSIVLADEPGEWREENGSLYW
                     YENGIKQGTEGRGKEIYDPASDGWYWLDAIDGGKKAVGKDVYQESWAGSYADHEDGTGK
                     WVRYDTSGKMVKGWDVTERGAYYFDQMTGAMAKGETEIDGIPCIFDRETGIGWNLQWQE
                     REGARYWYEGGKRQGLEGRGKEIYDPASDAWYWLDSDVQGKMAVNKDVYQPYTIQGQDE
                     TGKWVRYDADGHMVKGWDRQNESTYYFDQTTGAMAKGVAKIDGVSYYFNETTGVCEGEY
                     TPSDSSEPTNVTTYTANDQVSEYTENELDASGNVVKSTTYSASGVKKTERTDAFDQYGN
                     QIRGTYVIYRGGEVYSTATDETVYEYNADGQPLSMTCYNDSQMFSRVLYTYDNGKTAKV
                     EYYVPLDGEEELSNYEQYFYENGRCVRKENYVLSYTDGAWNISLDTSDYYAYNSNGNLI
                     RETNKSARGNVNYYYTYDYDASGNLIAKGCYAKDDSQQWKEVWAYEGTLLVSDYYYSEE
                     ALEYYIIYVNRQRSGHLYQKIEKSYAGDGTYSGKRVYTYEG"
     CDS             9043..9975
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_9"
                     /sec_met_domain="SIS (E-value: 1.5e-24, bitscore: 76.1,
                     seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTNDLSNRINDAYSKLSKGQKRLATYITDNYDKAVFLTAAKLG
                     EVVGVSESTVVRFATHLGYKGYPEFQSALEELVRNKLNSIQRMEVTYGRISQSKILETV
                     LKSDADKIHSTLEKIDQNAFELAVDTILHAKHIYIIGIRSCAPLASFMAFYFTLMFPNV
                     HLIQTSSSSEIFEQMVRIGKEDVIIGISFPRYSMRTLKAMEFANNRSAKVITLTDSVHS
                     PMNLYSSCNLIADSDMASIVDSLVAPLSVINALIVALCMKKQNEVAKTLEMLEDIWDEY
                     QVYENDEINYIDDSIKMRYGKVGDAELYE"
     CDS             9968..11197
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 58.2; E-value:
                     2.6e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_10"
                     /sec_met_domain="HI0933_like (E-value: 7.2e-137, bitscore:
                     446.1, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVIVVGGGPAGMFAAIAAAERGHEVVLLEKNEKLGKKLYITGK
                     GRCNITNAGDMDTLFANVMTNPKFLYSAFYDYDNQRVIDFFEENGLATKVERGNRVFPV
                     SDHSSDVIATLQRVLKRTGVMVQLHAEVRQILTGEGAVRGVKLADGSVLEAERVILATG
                     GFSYQTTGSTGDGYRFARELGHTVTQITPSLVPFYVKETCAARMQGLALKNVQVRIRDG
                     KKLLYDEFGEMLFTHFGVSGPLILSASAAIKPGRVEKELAMEIDLKPALTEDQLDARLL
                     REFEEAKNKQFKNAVVHLFPAKMIPVMLEAGAIDPEKKVNEITREERMGFVHLIKAFPL
                     TLCGVRDFNEAIITRGGVSVKEVNPSTMESKLVPGLYFCGELLDLDAMTGGFNLQIAWS
                     TGHLAGESIE"
     CDS             11216..11878
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_11"
                     /sec_met_domain="Cytidylate_kin (E-value: 5.5e-81,
                     bitscore: 261.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMNIAIDGPAGAGKSTIAKKLAKKLAFVYVDTGAMYRAMAYYFL
                     QNGIAPDDEQAIAAACPKVDVTIVYENGEQQVLLNGENVNGVIRTEEVGNMASATSVYP
                     VVRTKLVELQRQLATKTDVIMDGRDIGTCVLPDAQVKIYLTASVATRAKRRYDELTAKG
                     TQCNLEEIEKDIEDRDYRDMHRETSPLKQAKDAVLVDSSEMNIDEVVDAIYQIYARV"
     CDS             11884..12735
                     /locus_tag="ctg78_12"
                     /transl_table=11
                     /translation="MNVILAKSAGFCFGVKRAVDTVYERILEKEPLYTFGPIIHNEEVV
                     RDLEEKGVVVVNDVDELAGKPQGTVIIRAHGVERGVCEKIQALGFSIVDATCPFVLKIH
                     RLVERYSGEDCHIVIVGNASHPEVKGIKSWSNAEDTRVIGTREEAEKYDASHGKKVCIV
                     SQTTFNYNKFQELVEIIKEKGYDIIVLNTICNATEERQTEARAIAEQVDAMIVIGGRNS
                     SNTQKLFEICKNECKNTYYIQTVKDLDLAEVRSVDNVGITAGASTPNNIIEEVQKNVRN
                     EL"
     CDS             12740..13411
                     /locus_tag="ctg78_13"
                     /transl_table=11
                     /translation="MLEESFKTIRNGEVVEGTVIDVKPDEIVLNIGYKADGIITRNEYT
                     NEANVDLTTLVSVGDTMEAKVLKVNDGEGQVLLTYKRLAAEKGSKRLEEAFENKEVLTA
                     KVAQVLDGGLCVNVDETRVFIPASLVSDTYEKDLSKYKDQEIEFVISEFNPKRRRIIGD
                     RKQLLVAKKLEQQKELFARIKIGDVLEGTVKNVTDFGAFIDLGGADGLLHISEMSWGRV
                     ES"
ORIGIN
        1 gacccgcgga gtgctccaaa cttggaaaga cacggatcat cgaagatgca aacatccggc
       61 tggttagaaa tgccacattt tttgaaccga atttccatct gcattttcat ctgaaatccc
      121 acggtgtagt ctgcttataa tattacttat caaagcaaag cacgatatgc ttattgcggc
      181 agttcctttt tgcgtgccgt ttctgttctg caaaaaatga gggacgcata tacatcagtg
      241 aagtcatttt gggagaatgg catgtatcga cgctttcttt ctctattgtt aagtatgagt
      301 ttacttattt tttcgcctgt gcgtgtccgg gcgcaggatg tgccggcaga gtcggaactg
      361 tacgcaaaat ctgccgtttt gatggatgcg gattccggaa gaattctcta tgagaaaaac
      421 gggcatgaag cgatggcgaa tgcgagcacg acaaagattt taacctgtat cgtggcactg
      481 gaaaactgtg atccggcgag cgtggttacg gtgtcaaaaa atgcggcgtc ccagccgaag
      541 gtacatctgg ggatgcacga gggacaacag ttttatctga gggatctttt atatggcctg
      601 atgctggaat cctacaatga ctgtgcggtg gccatcgcgg aatttgcggc gggggaggtg
      661 cagggatttg ccgcgctgat gaatgcgaag gcagaggaac tcggctgtga ggacagctac
      721 tttattacac cgaacggact ggatgcgaag gatgatgccg ggtttcatca cacgacggcg
      781 gcagaccttg ctaagattat gaaatattgt attaaggaat cgttaaaaag cgacgaattt
      841 ctcgagatta cacggacggc gcagtattct ttttctgatg cagaggggaa atgcacgtac
      901 cagtgcacga accacaatgc atttttgcag atgatggaag gggcgctttc cggaaaaacg
      961 ggatttaccg gaaccgccgg atactgctat gtaggagcgc tgcagcggga ggacaaaacg
     1021 ctgatcgtgg cgctgctcgc ctgtggatgg ccgaacaaca agacctataa gtggtccgac
     1081 accagaaaac tcatgaatta cggattggag cagttcaaaa agatcgacct gctgcagatt
     1141 gagccggacg aagcggagct tgcgcccata gaggtgcggg acggacaggg cggaaaaatc
     1201 ggcgaaacgg tgtatttaaa accggttgtc aggaactatg caggggagga gagtatcctg
     1261 gcgccgctaa gcagtgaggt tacgcttaag tatgagattg cagaccggct gtatgcaccg
     1321 gtgaagagcg gcgagtacat cgggaagatt cgttatatgc tgggggagga gacgctcgcg
     1381 gagcgatgtg tggtagccgg ggagacaatc ggaaagatcg attatccgtg gtgtctgggg
     1441 caggtgcttc ggcttctctg gatcgaataa aaaacacaaa caaaaagcgt caaaaaatta
     1501 acaatttact tgaaatattg cagaaaagca attataattt aacatagcgt aatttgttga
     1561 atttttatac aaagacgcat ggatttacat cattcactat gaagccgcat cccaaatgga
     1621 tgtggacaac aatttataga tggagggcaa aaagaatgaa tagtagcaat gatagcctgg
     1681 ctatgcagcg catcaccagg ttagtcgacg agaacagttt cattgagatc ggttctctcg
     1741 taaccgcaag aagcacagat tttaatcttg cagcaacgga tactccttcc gacggagtca
     1801 tcacaggaca cggcctgatt gacggcaatc tggtgttcat ttacagccag gatgcttctg
     1861 ttttaaacgg aacaatcggc gagatgcatg cgaagaagat cgctgcagtg tatgacatgg
     1921 cgatgaagat gggagcaccg gtgatcggct ttatcgattg cgcgggagtc cgtttacagg
     1981 agtctgtaga tgcgcttgac ggcttcggac tgatctatgc aaaagaagtt gcagcatccg
     2041 gcgtggttcc gcagatttca gccgtattcg gcagctgcgg cggtggactg gcagtggtac
     2101 cggcactttc tgattttgct tttatcgaag aatccaaagg aaagatgttt gtgaattctc
     2161 cgaacgcaat tgacggaaac cgcatcgaga agtgcgacac atcatctgcg gcattccagg
     2221 cagatgagaa cggctgcatc gacgcgacgg gaacagagga tgagattctt acagacatcc
     2281 gtgagctggt cggcatgctt ccgctcaaca acgagggaga tgtctacaca gacgagtgtg
     2341 cggatgacct gaaccgtgca tgcgagagca tggatgccat gaagggtgat ccgagatatc
     2401 ttctcagtga gatttcggac agccatacat tcttcgagac aaaggcaggc tatgccagag
     2461 atatggtgac cggatttatc aagttaaacg gtatgacggt cggcgcagtt gcaaactgca
     2521 caacggtata cgacgaagag ggcaaagaga gcgagaagtt tgacaatgtt ctttctgcaa
     2581 agggatgtga gaaggcagca gagttcgtat ctttctgcga cgcattcgag attccggtac
     2641 tgactctgac aaatgtcaag ggctacaagg catgcaagtg ctctgaaaag cgtcttgcaa
     2701 aggcacttgc tcatctgacc tccgcatttg cgggagctac atgtccgaag gtgaacctga
     2761 tcacgggaga ggcatacggt accgcttatg ttgctatgaa ttccaagtct atcggtgcgg
     2821 atttcgtata tgcatggccg gacgcaaagg tcggcatgat ggatgcggat cttgcagtaa
     2881 agatcatgta cgcggatgca tctgcggatg agcttgcaga gaaggcaaag gaatatgatg
     2941 cactgcaggg cagcgttatg acagcagcca gaagaggcta tgtggatctg atcgttgatc
     3001 cggcagatac gagaaagtat ctggtagatg cgtttgaact gttatacaca aagtgtgcat
     3061 atacaccgga caagaaacat ggaacaaaat agaaaggtga agtttatgaa gaaaaaatta
     3121 tctcttatac tttgtctttg ctttatggct ctgggacttg cagcatgcgg aacagatccg
     3181 acaacggttg actatttcgg aatgacttac gatgaactgc agagcagcat ggaacaggaa
     3241 gtttccgcgc tggttggtct tacggacgac aacagaacct atatccagtc ctacggcagc
     3301 gatacggcaa tgaaacttgt cgagagctgg gatgaggcga caagtgatgt cggcgcatat
     3361 cagggacttg gagaattcaa tatcacaaag gcacagaaaa ccttaacagt agatcagtat
     3421 gtagagtatc agaatcgtga agtcatcgtt tcttacatct atacatacaa ttacgagacc
     3481 gagcagccgg agcttaccga tgcaaccgcg gacaaggtat atacgctggg tgagaagatg
     3541 gagaaggctg cgttaaatac cctgatggga atgggaaccg tattcgtggt tctgatcctg
     3601 atcagcctta ttatttactg tttccgcttt atctctgtaa tacagaacaa ggcggccggc
     3661 aagggcaaga agaacgaggc agaggcaggc gctgtggtag agcagatcgg acagcgtgaa
     3721 gagcagctta ccgatgatct tgaacttgtg gcagttattt ccgcagcggt tgcggcaagc
     3781 accggtgcat ccgcggattc tttcgttgtg agatcgatcc gcagacgcta attcgtataa
     3841 atgaaaagaa atcatattag gaggatattt caatgaaaag ctatacaatt acagtaaacg
     3901 gaaatgtata tgatgtaacc gtagaagaga acggcgcagt gagcgcaccg gcagcagcac
     3961 cgagacgtgc agcagcaccg gcggcagcac ctgcagcaaa gccggctgct gcagcaggcg
     4021 caggcagcgt taagattgag gcaggcgcag caggaaaggt attcaaactt gagaagtctg
     4081 tcggcgacgc tgttaagaag ggagacagca tcatggttct tgagatcatg aagatggaga
     4141 ctccggtcgt tgcaacgcag gacggtacgg tagcaagtat caacgtaagt gttggagata
     4201 tggtagaagc gggcgcatta cttgcaacat taaactaatt taggaggaag acaatgagct
     4261 attttagtga gacaatgggg aacctcctgc atcagaccgc tttctttaac cttacctggg
     4321 gaaattttgt gatgatcatt gtcgcatgct ttttcctgta tctggctatc gcgaaggggt
     4381 ttgagccatt gcttcttgtt ccgattgcat tcggtatgct gcttgtaaat atctatccgg
     4441 atatttttgc agacccggag cagatgagca atggtgtagg tggtttattc cactactttt
     4501 atgtgttaga cgagtggtca atcttaccgt ctctgatttt ccttggagtc ggtgctatga
     4561 cagatttcgg accgctgatt gcaaacccga tcagtttcct gcttggagct gcagctcagt
     4621 tcggtatttt cggagcgtac ttccttgcaa tcatgatggg ctttaatgat aaggcagcag
     4681 ctgctgtttc catcatcggt ggagccgatg gaccgacctc cattttcctt gccggaaagt
     4741 taggacagtc gggactgatg ggaccgatcg ctgtggcggc atattcctat atggcgcttg
     4801 tgccgatcat ccagccgcca attatgaagc tgtttacaac caaaaaagag cgcgccatca
     4861 agatggagaa cttaagaccg gtttccaagc tggagaagat tctcttcccg atcgtggtta
     4921 cggtggttgt atgtacgatt cttccgacga cagcgccgct ggttggtatg ctgatgctcg
     4981 gtaacctgtt ccgcgagagc ggtgtggtcc gccagctgac cgataccgca tccaacgcat
     5041 tgatgtacat cgtagttatc ctgctcggta cttccgtagg tgcatctacg agtgcggagg
     5101 cgttcttaaa tacaacgaca ttaaagatcg ttgcacttgg actgattgca tttatgttcg
     5161 gtacagcagc cggtgtcctg tttggtaagc tgttatgctt cctcacaaag ggcaagatca
     5221 atcctctgat cggatctgcc ggtgtatctg ccgttcctat ggcagcccgt gtatcccaga
     5281 aagtcggcgc ggaggaagat ccgacgaact tcctgctgat gcatgcgatg ggaccgaacg
     5341 ttgccggcgt tatcggtact gcagtagcag ccggtgtatt catggcaatt ttcggaattt
     5401 agtgaaagag taaatgccgt catagacgga tagcggtatc aaagtatccg ctgataagga
     5461 ggaaaaaatg tcagaagttg ttaaaaaacc tttaaaaata acagagacgg tgctgcgtga
     5521 tgcgcaccag tctctgattg cgacaagaat gacaaccgag cagatgcttc cgatcgtaga
     5581 caagatggat aaggtcggat acaatgcggt tgagtgctgg ggcggtgcta ccttcgatgc
     5641 atgccttcgt ttcctgaagg aagatccgtg ggatcgtctc cgcaagttaa gagacggatt
     5701 taagaacacc aagcttcaga tgctgtttcg tggacagaac atcttaggat atcgtccgta
     5761 tgcagatgat gtggtagagt attttgtaca gaaatctatc gcaaacggta ttgatatcat
     5821 tcgtattttc gactgcttaa acgatgtccg caacctgcag acagccgtta ccgcatgtaa
     5881 caaagagaaa ggacatgcac aggtcgcatt atcctataca cttggcgatg cctacactct
     5941 ggattactgg atggagatgg cgaagaaggt agaggatatg ggtgctgatt ccttatgtat
     6001 caaggatatg gcaggtcttt tggttccgac gaaggcaacc gagctgattc aggcattaaa
     6061 gtctgcaacc aaccttccga tcgagctcca tacacactat acttccggtg tcgcttccat
     6121 gacatacatg aaggcggttg aggcaggctg tgacattatc gatacagcaa tgtctccgtt
     6181 ctccatggga accagccagc cggcaaccga ggttatggtt gaggcattca agggcacaga
     6241 gttcgatacc ggtctggatc agaacctgtt agctgagatc gctgactact tccgtccgat
     6301 gcgtgaggaa gcgttagaga gcggtctgat gaacccgaag gttctcggcg ttaacatcaa
     6361 gactctgtta tatcaggtac cgggtggtat gttatccaac cttctgtctc agttaaaaga
     6421 gcagggcaag gaagacaagt tcgaggaggt tcttgcagag gttccgcgtg tgcgtaaaga
     6481 cctcggtgag ccgccacttg ttacaccgtc ctcacagatc gttggtacac aggctgtgtt
     6541 caacgtactg atgggagagc gctacaaagt ggcaaccaag gagaccaaag acgtactgct
     6601 tggaaagtac ggtcagactg taaaaccgtt caacccggag atcgtagaca aggtacttgg
     6661 cgaggagaag aagaacgcca ttacctgccg tccggcagat ctgcttgagc cggagctgga
     6721 taagatcgag gctgagatga agcagtggaa gcagcaggat gaggatgtac tgtcctacgc
     6781 actgttcccg caggttgcaa ccgaattctt caagtaccgt gaggcacagc agaagaaggt
     6841 cgatgcaagc gtcgcagata ccaagaacgg agcatatccg gtataatcaa aaacagttaa
     6901 aacaaaaagc gggtgagcag tcacctgctt tttgttttaa aaatgggaaa attatgaatg
     6961 cagggtattt gcagtaacat tttattgaaa aaaagagagt gtttcagtat cataggaata
     7021 tgaatcgcag gatgatttga gatgcagtat cgaatgcaaa acagtaaaac aacaaaaaag
     7081 aggatgacat gagaaaaaaa gaggataggt tgaaaacagc agcatttgtt ttgagcgcag
     7141 gggtgttttt tggtgtatgc ccgtcgattg tgctggcaga tgagccggga gaatggcggg
     7201 aagaaaatgg cagtctctat tggtatgaaa atggcataaa gcagggaaca gaaggaaggg
     7261 gcaaggagat ttatgatccg gcgagcgatg gctggtattg gctggatgcc attgatgggg
     7321 ggaaaaaggc ggtcggaaag gatgtgtatc aggaatcatg ggcaggatct tatgcagacc
     7381 atgaggacgg caccgggaaa tgggtgcgct atgataccag tgggaaaatg gtaaaaggct
     7441 gggatgtgac ggagagaggt gcatactatt ttgaccagat gaccggagcg atggcaaaag
     7501 gagaaacgga gatagatgga ataccatgta tttttgaccg ggagacgggc attggctgga
     7561 atctgcaatg gcaggagaga gagggggcac gatactggta tgaaggagga aaacgtcagg
     7621 gactcgaagg cagagggaag gaaatctatg atccggcaag tgatgcatgg tactggctgg
     7681 acagcgatgt gcaggggaaa atggcggtaa acaaggatgt ttatcagccc tatacaattc
     7741 agggacagga tgagactgga aaatgggtac gctatgatgc agatggacat atggtaaaag
     7801 gctgggacag acaaaatgaa agtacctatt attttgatca gacaactgga gcgatggcaa
     7861 agggcgtggc gaagattgat ggtgtcagct attattttaa tgaaacgacc ggtgtttgtg
     7921 aaggggagta tacaccatca gacagcagtg agccaacaaa tgtgacaacc tacacggcaa
     7981 acgatcaggt cagtgaatat acagaaaatg agttggacgc gtcaggcaat gtggtaaaaa
     8041 gtacaactta cagtgcatca ggagtaaaaa aaacagaacg taccgatgca tttgatcagt
     8101 acggaaatca gatccgggga acttatgtta tatatcgggg aggagaagtt tattcgacag
     8161 caacggatga gacagtgtat gagtataatg ccgacggtca gccattatcc atgacatgtt
     8221 ataatgattc acagatgttt tcgcgggtac tttatacata tgacaatgga aagactgcaa
     8281 aagtagagta ttatgttccg ctggatgggg aagaagaatt aagtaattat gaacagtatt
     8341 tttacgaaaa cggaagatgt gttcgaaagg aaaattatgt gctcagctat acagatggtg
     8401 cgtggaatat tagcttggat acatcggatt attatgcata taacagtaat ggaaatctga
     8461 tccgtgagac caataagagc gccagaggga atgtgaacta ctattataca tatgattatg
     8521 atgcgagtgg caatctgatt gccaagggct gttatgcaaa agatgacagt cagcagtgga
     8581 aggaagtctg ggcttatgag ggaacgcttc tggtaagcga ttattattac agtgaagaag
     8641 ccctggaata ttatattatc tatgtaaaca gacagcgcag cggtcattta tatcagaaaa
     8701 tagaaaaatc ttatgcggga gatggaacgt attccggtaa aagggtctac acttatgaag
     8761 gttagaggga aacggacaac ccggtttcct tcccttaccg tatgacaccg ccggtaatct
     8821 gttttctgga gcagccggca ggcttcgttg caaagttatc cggcatccgg tgaatgatga
     8881 aaaatcttcc gatgataaca atgctgttgg tttaatatat gcagcgttgg aaaatgcgct
     8941 gcatgtgagg aaagttccat gtacaatttc ttgcaaaaca caatgtattt gatataataa
     9001 aaacattggg cggatcacaa ttccgcagaa gtgaggagaa gcatgagcaa tacaaatgac
     9061 ctgagtaacc gcatcaatga tgcttacagc aagctgagca aagggcagaa acgtctggca
     9121 acctacatta cggacaatta tgacaaggcg gtatttctga ccgccgcaaa gctgggtgag
     9181 gttgtgggcg tgagcgagtc cacggtggta cgctttgcga cacatctggg atataagggc
     9241 tatccggaat tccagagtgc gctggaggaa ctggtgcgca ataagctgaa ttctattcag
     9301 cgcatggagg ttacttacgg caggatcagc cagtcgaaga ttctggagac ggtgctgaaa
     9361 tccgacgcgg acaagatcca ttccacactg gaaaagattg atcagaatgc atttgaactc
     9421 gcggttgaca cgatcctgca cgccaaacat atctatatca tcggaatccg gagctgtgcg
     9481 ccgcttgcca gcttcatggc tttttatttt accctgatgt ttccgaacgt tcatctgatt
     9541 cagacaagca gttcgagcga gatttttgaa cagatggtgc gcatcggcaa ggaggatgtg
     9601 atcatcggaa tcagttttcc gcgttattcc atgcgtactt taaaggcgat ggaatttgca
     9661 aataaccgga gtgcgaaggt aatcacactc accgacagcg tacattcccc gatgaacctc
     9721 tattcttcct gcaatctgat tgcggacagc gatatggctt ccattgtgga ttccttggtt
     9781 gccccgctgt cggtgatcaa tgcgctgatt gtggcgctct gcatgaaaaa gcagaacgag
     9841 gtggcgaaaa cgcttgagat gttagaggat atctgggacg aataccaggt ttatgagaac
     9901 gatgagatca attatatcga tgattccatc aagatgcggt atggaaaagt aggagatgcg
     9961 gaactgtatg agtaaggtga tcgtagtcgg cggcgggccg gcgggaatgt ttgctgccat
    10021 tgcggcggcg gagcggggac atgaggtcgt tttgctcgag aaaaatgaaa agctagggaa
    10081 aaagctctac atcaccggca aagggcggtg caacatcacg aatgcggggg atatggacac
    10141 cctgtttgcc aatgtgatga cgaacccgaa gtttttatac agcgcttttt acgattatga
    10201 caatcagaga gtgattgatt tttttgagga gaatggtctg gcgacgaagg tggagcgcgg
    10261 caaccgtgta ttcccggtat cggatcattc ttcggatgtg atcgccacgc tgcagcgggt
    10321 actaaagcgc acgggtgtta tggtgcagct tcatgcggaa gtgcggcaga tcctcaccgg
    10381 ggaaggcgcg gtgcgcggcg tgaagcttgc cgacggaagc gttcttgaag cagagcgcgt
    10441 gattcttgca accggaggat tttcttatca gacgaccggt tcgactggag acggctaccg
    10501 ttttgcgagg gaactcggac atacggtgac acagattacg ccgtcactgg ttccgttcta
    10561 cgtgaaggag acctgcgcgg cgaggatgca ggggctggcg ctgaaaaatg tgcaggtgcg
    10621 catccgggac ggaaaaaagc tgttgtatga cgaattcggc gagatgctct ttacccattt
    10681 cggggtaagc ggaccgctga ttttaagcgc cagtgcggca atcaagccgg gccgcgtgga
    10741 gaaggaactg gcgatggaga tcgacttaaa gccggcactc acggaggacc agctggatgc
    10801 gagacttctg cgtgaattcg aggaggcaaa gaataagcag tttaaaaacg ccgtcgtgca
    10861 tctgttcccg gcgaagatga ttccggtgat gttagaagcc ggagcgattg atccggagaa
    10921 gaaggtcaac gagatcacga gagaggagcg gatgggattt gtgcatctga tcaaggcgtt
    10981 tccgctgacg ctctgcggtg tcagagattt caatgaagcg atcatcacac gcgggggtgt
    11041 cagcgtaaag gaagtgaacc cttccacgat ggaatcaaag cttgtgccgg gattgtattt
    11101 ctgcggggaa ctattggatc tggatgcgat gaccggcgga tttaatctgc agattgcctg
    11161 gtcgaccggg catctggcgg gtgagagtat cgaatagaag aggagagaag aagagatgag
    11221 tatgaatatt gcgattgacg gaccggcagg cgccgggaag agcacaattg cgaaaaaact
    11281 ggcgaaaaag ctggcgtttg tctatgtgga tacgggagcg atgtaccgtg cgatggcata
    11341 ctatttttta cagaacggca ttgcaccaga tgatgagcag gcgattgcgg cagcctgccc
    11401 gaaggttgac gtgacgattg tgtatgagaa cggcgaacag caggtgctct taaacggaga
    11461 gaatgtaaac ggcgtcattc ggacggagga agtcggcaat atggcatcag cgaccagtgt
    11521 ctatccggtt gtgcgcacaa agcttgtgga actgcaacgg cagcttgcga caaagacgga
    11581 cgtcatcatg gacggaaggg atatcggcac ctgtgtgctt ccggatgcgc aggtaaaaat
    11641 atatctcacg gcaagcgttg cgacgcgcgc aaagcgcaga tatgatgaac tgaccgccaa
    11701 gggaacccag tgcaatctgg aagagatcga gaaagatatt gaagaccgcg attaccgcga
    11761 tatgcaccgg gagacgtcgc cgttaaagca ggccaaggat gcggtgttag tggacagctc
    11821 cgagatgaac atcgacgaag tggtggacgc aatctatcag atttatgcga gggtatagag
    11881 aatatgaatg taatcttggc aaagagcgcg ggcttctgct tcggggtaaa acgtgccgtg
    11941 gatacggtat atgaacggat tctggaaaaa gaaccgctct acacgttcgg accgatcatc
    12001 cacaatgaag aagtggtgcg cgatctggag gaaaagggcg tcgtcgtggt aaacgatgtg
    12061 gacgaacttg cggggaagcc gcaggggacg gtaatcatcc gggcacacgg cgtggagaga
    12121 ggtgtctgcg agaaaataca ggcgctcggt ttttccatcg tggacgcgac ctgcccgttt
    12181 gtgttaaaga ttcaccggct ggtggagcgc tacagtgggg aggactgtca cattgtgatc
    12241 gtcgggaatg ccagccaccc ggaggtgaag ggcatcaaaa gctggtcgaa tgcagaggat
    12301 acgcgcgtga tcggaacccg cgaagaggcc gaaaaatacg atgcttccca tggaaaaaag
    12361 gtatgtattg tatcacaaac gacatttaat tacaataaat ttcaagaatt agttgaaatt
    12421 ataaaagaaa aaggttatga tataattgtt ttaaatacaa tctgcaatgc tacggaggaa
    12481 cgtcagacgg aagcccgggc aatcgcggag caggtggatg ccatgattgt gatcggtggc
    12541 aggaacagct ccaacacgca gaagctattt gaaatatgta aaaacgaatg caaaaatact
    12601 tactatatac aaactgtaaa ggatcttgac cttgccgaag tcaggtctgt cgataacgta
    12661 ggtattaccg caggggcttc taccccaaac aatattattg aggaggttca aaagaatgtc
    12721 agaaatgagc tttgaacaaa tgctggaaga atcatttaaa acaataagaa atggagaggt
    12781 agttgagggt accgttatcg atgtgaaacc tgatgagatc gttctgaata tcggctacaa
    12841 ggcagacgga atcattactc gtaatgaata cacaaacgaa gcaaacgtag accttaccac
    12901 attggtatcc gtcggcgaca ccatggaagc aaaggtttta aaggtaaatg acggtgaggg
    12961 tcaggtatta ctgacataca agcgtctggc tgccgagaag ggaagcaaga gattagagga
    13021 agcatttgag aacaaggaag tgctgaccgc taaggttgca caggtactgg atggaggatt
    13081 atgcgtaaac gtagatgaga caagagtatt tattccggca agtcttgtat cagataccta
    13141 cgagaaggat ctttccaaat acaaggatca ggagatcgag ttcgttatca gcgagttcaa
    13201 tccgaagaga agaagaatca tcggcgacag aaagcagctt ctggttgcta agaagttaga
    13261 gcagcagaaa gaactgttcg caagaatcaa gatcggtgat gtattagagg gaacagttaa
    13321 gaatgtaaca gatttcggtg cgtttattga tcttggcgga gcagacggtc tgcttcatat
    13381 ttccgagatg tcctggggca gagtagagag cc
//
