LOCUS       c00028_gnlPro..        16760 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LHOKEKIH_28.
ACCESSION   c00028_gnlPro..
VERSION     c00028_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 02:24:59
            Original ID  :: gnl|Prokka|LHOKEKIH_28
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16760
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1326)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_1"
                     /sec_met_domain="HI0933_like (E-value: 1.9e-104, bitscore:
                     339.3, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPEVHIYIDRSEAKTWNHDEIDNLQGKINTGEYSMSKVIIIGGG
                     AAGMMAGVFAARNHHEVHILEKNEKLGKKVFITGKGRCNVTNACDTEELFPAMMSNPKF
                     LYSSFYSFTPQDVMEFFEKAGVPLKVERGNRVFPQSDHSSDIIRALERELKKAGAKIHL
                     HTAVQEIVKKPVTDSANTLESEAALTESGFAAGKGRKGKKSPDIPQEKITGVILTDGTF
                     MEGDAVIVATGGFSYQSTGSTGDGYRFARELGLKVTDIAPSLVPLKTKEDYIPKLQGLS
                     LKNTGLTIKNGKKVLYEDFGEMMFTHFGVTGPMILSASAHIGAKLAKAPNGELSAYLDL
                     KPALTREQLDARILREFEAGPNKQFKNVIGVLFPSSLTPVMLELGGIPAEKKIHDISRE
                     ERQHFIDLIKAFPLTITGMGEFKEAIITRGGVSVKEINPGTME"
     protocluster    1..16760
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1437:6760]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1438..6760
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16760
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16760
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(1438..2850)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_2"
                     /sec_met_domain="HMGL-like (E-value: 4.6e-47, bitscore:
                     150.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 5.2e-59, bitscore:
                     189.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELEKKPVKIVETILRDAHQSQIATRMTTEQMLPIVDKLDKVGY
                     HAVECWGGATFDASLRFLHEDPWERLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSAANGIDIIRIFDCLNDLRNLQTAVSAANKEKAHAQVALSYTLGDAYTLEYWTD
                     IAKRIEDMGADSICIKDMAGLLLPNKATELVTALKETVKIPIDLHTHYTSGVASMTYLK
                     AVEAGVDIIDTAMSPFALGTSQPATEVMVETFKDTPYDTGFDQKLLSEIADYFRPIRDE
                     ALDSGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYDVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKMVTKETKDILLGKYGATVKPFNPEVQKKCIGD
                     EKPITCRPADLLDNELEKLESEMAQYKEQDEDVLTYALFPQVAMDFFKYRQAQKTKVDE
                     KAADKKNGAYPV"
     CDS             complement(2993..4141)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_3"
                     /sec_met_domain="OAD_beta (E-value: 5.4e-157, bitscore:
                     511.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVTETLSNLIHQTAFFSLTWGNYLMIAVACVFLYLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMANPEDMSNGVGGLLHYFYILDEWSILPSLIFMGVGAMTD
                     FGPLIANPISFLMGAAAQLGIYAAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLAGKL
                     GQSALMGPIAVAAYSYMSLVPIIQPPIMKLCTTEKERKIKMDQLRPVSKLEKILFPIVI
                     TIVVCLILPTTAPLVGMLMLGNLFRECGVVKQLTETASNALMYIVVILLGTSVGASTSA
                     EAFLNADTLKIVVLGLVAFAIGTFGGCMLGKLLCKLTHGKINPLIGSAGVSAVPMAARV
                     SQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             complement(4158..4526)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63; E-value:
                     6e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.3e-20, bitscore:
                     63.0, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGTAYEVTVEETGSVSAPAAAPKAAPKAAPAAAPKAA
                     APAAGAGAVKVTASVPGKVVKVAASVGQAVKAGDSVVILESMKMEIPVVAPQDGTIASI
                     DVAEGASVENGDTLATMN"
     CDS             complement(4554..5276)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_5"
                     /sec_met_domain="OAD_gamma (E-value: 8.2e-28, bitscore:
                     86.8, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFLVMAALVIGSTSVVFAADKVDDTVKSTLVTTAEGLTDAIVQL
                     KDEEIENYMSSGDDFTTSAMQSWQTSKDELGAKKDSNGETTVTFKDDQYTVTVPLKFEK
                     AEANFVYVFDSQGTPTSMSVDVQYGMGKTLQRAGLNTLMGIGTVFVMLILLSLLISLFR
                     FIPNPEAKKAAEAKAAKAAKEAEAAAIAQTAPAQAEENLADDGELVAVIAAAIAAAEGT
                     TTDGFVVRSIRKVKRNRR"
     CDS             complement(5324..6760)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_6"
                     /sec_met_domain="CT_Vparvula (E-value: 1.3e-136, bitscore:
                     445.9, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNATQSLAGTRITSLLDANSFVEIGQGVTARSTDFNMTANKAPS
                     DGVITGYGVIDDKLVYVYSQDASVLNGTVGEMHAKKITRLYDLAMKTGAPVIGLVDCAG
                     IRLQEATDALEAFGQIYLKQTLASGVIPQITAIFGTCGGGMAVIPSLTDFTFMESKKGK
                     MFVNTPNALEGNNTDKCDTAAADFQSKETGVIDGVGTEDEILGQIRSLVSLLPSNNEDT
                     DNYTECTDDLNRVCADLANCAGDTAIALSQIADNGEFFETKADYAKDMVTGFIRLNGAT
                     VGAVANRSEVYDAEGKKAETFDGSISARGARKAADFVKFCDAFDIPVLTLTNATGFMAT
                     LCSEKMMAKSVGELVAAFADATVPKVNVIIGKAYGTAYVAMNSKSIGADLVYAWDNAEI
                     GMMDASLAAKIMYADADAAELNEKAAQYRELQNGVASAAARGYVDTVISPADTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
     CDS             7627..9576
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) baiH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_7"
                     /sec_met_domain="baiH (E-value: 1.4e-141, bitscore: 462.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIKNRIVMMPMGTNYGEQNGEMSFLHINYYKERAKGGTGLIIVE
                     NASVDSPQGSNGTTQLRIDHDNYLPRLYKFCEEIHKYGTCIAIQINHAGASAVSARTNM
                     QPVSASDVPSKEGGEIPRPLSVEEIHHIVKKYGEAAKRAQAAGFDAVEIHAGHSYLISQ
                     FLSPLTNKRTDEFGGSVENRTRFCRMVIEEVRKQVGPFFPIMLRLSADELMEGGNTLED
                     TLEYLEYIQDEVDIFDVSCGLNGSIQYQIDANYMKDGWRSYMPKAVREKFGKPCISMGN
                     IRNPKVAEQILADGDADLIGMGRGLIAEPAWVNKVATGRECDLRKCISCNIGCAGNRIG
                     FNRPIRCTVNPAVLEGDVYKNQKVNKNCNVVVIGGGTAGLEAACTAAEVGCNTFLLEKG
                     ETLGGLASVISKIPAKKRLADFPNYLIHRAEQLENLYIFTNTEGTPENIRKFHPNLIVS
                     STGSAPLLPPIRGLHDRIDKEGSKVASILGMINHINDYPEDMTGKKVVVVGGGAVGLDV
                     VEFFAARNAEISIVEMMDQIGRDLDPVTKNDMKDQMKKHHVAQLTKTALQEVKDSSFLV
                     KDAEGERELPFDYGFVCLGMRAQGQLFAELSDAFVSDDVEILNIGDSKRARRIIDGTLE
                     GRNILNTLTQMGYL"
     CDS             9616..10494
                     /locus_tag="ctg28_8"
                     /transl_table=11
                     /translation="MAERITGHTELIGLMAYPIRHSSSPAMQNEAFAKLGYDYAYLAFE
                     VGADEIEDAVKAIRTLKMRGSNVSMPNKTLVGKYLDELSPAAELCGAVNTIVNDNGHLT
                     GHITDGIGFMSALKDNDIDVIGKKMTIVGAGGAATAIEIQAALDGVAEITIFNRKDEFW
                     DRAVSTVEKINTKTSCHAVLYDLADLDKLKAEMDDSFIFVNATGVGMKPLEGQSVVPDK
                     SYFRPELIVIDVPYSPLETKMRSMAKEVGCKTMNGLGMMLFQGSAAFELWTGEPMPIEH
                     MKEILHISYDD"
     CDS             11007..11291
                     /locus_tag="ctg28_9"
                     /transl_table=11
                     /translation="MMQDFGADIPKMAVMPTCKQDVLTLLSATLEMSEKYADRPIITMS
                     MAGTGVVSRLTGETFGSALTFGAASKASAPGQVGVHELKQVLDIIHSSL"
     CDS             complement(11472..14117)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_10"
                     /sec_met_domain="MFS_1 (E-value: 3.2e-16, bitscore: 48.9,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQKTNKMLIFTSLAAYFTYFIHGIGASILGQYKPEFAAAWGAKP
                     LADGTLDVSMVVSVIAALGLGRLISLPFSGPLSDKYGRKLSGIIGVLCYVAYFFGMANS
                     TSMAMGYAFAVIGGIANSFLDTCVSPTCMEIYVNNPSVANLFTKFSICLSQFLLPFLIG
                     IVASANMSYKTIFIVAGIAILIDGILILVLPFPAREKAVQAKADKKKSGHKISPAAIAA
                     ILIGFTSSSTFMLWLNCNQELARSYGMADPSKIQSLYALGTATAILATAAFIKKGLKEI
                     NVLIIYPLISTIMLVLCYFIQAPFICLIGGFVIGYAGAGGVLQLAVSTTAEFFPENKGT
                     ATSLVMIASSIANYTILSLAGYITKVGGSSAPRMILLLNMAVTIVGILLALFVKKNRNX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTRTQRRENELPYIPFGPFQIRLPFIH
                     YKIESVEFIQGLILGVTALAAVPYLEQYLGLPYELAWSCVIIETFLYLLHSLLGDPVVP
                     GWITPTLPLTIVFLEGFPMGKERIQAMIALQMLVGLVFIFMGVTRLADKFVHAVPNSVK
                     GGILLAAPVTVMAGQLGENGNMHKYPLAIVAGVGLLILISFSDKYQEKRKTNKFLDLVA
                     RYGNLFPYLIAMVVGLLVGELDAPGLEIGTFIKIPQFKDIIDQVSIFGVGIPPASMFIK
                     ALPLALVCYVIAFGDFVTTETLVSEARQARDDEYIDFNSSRSNLVSGLRNLILSIIAPF
                     PPLSGPLWVGMTVSVSMRYKEGKKAMKSLLGGMASFRLATFLSVLIIPVVSFFRPIFGV
                     GSSITLMFQAFVCARIGMDYCKSDRDKMIAGVMAAVLATQGTAWASAWALAVGFGLNIF
                     LSNWNPLEKK"
     CDS             complement(14138..15088)
                     /locus_tag="ctg28_11"
                     /transl_table=11
                     /translation="MILSADSSLKMILQKNSGGKQEMEQRIKGTTGLMALIGSPVGHSG
                     SPAMYNFSFRYHNLDYAYMAFDIKEDQVPAALDAIRLFKMRGANVTMPCKNEVAKHMDE
                     LSPAARIIGAVNTIVNENGKLVGHITDGIGFVRNLKEHGVDVKGKKMVVLGAGGAATAI
                     QVQCALDGAESISIFNPKDPFFARAESTAEKLSKETPDCKVSVFDLADEAKLKEEVANA
                     DILVNATLAGMKPHEELTLIKDKSMFRPDLVVADVVYNPAETRMVKEAKEAGCKLAIGG
                     KGMLLWQGAAAYKLYTGLEMPTAEYQKFQEENENK"
ORIGIN
        1 ttccattgtt ccggggttga tctctttgac agagacgccg cctctggtga tgatggcttc
       61 tttgaactca cccattcctg tgattgtgag ggggaaggct ttgataaggt caatgaagtg
      121 ctggcgttct tctctggaga tgtcgtggat tttcttctct gcggggattc cacccagttc
      181 cagcattacc ggagtcagag atgacgggaa aagtacgcca atcacattct tgaactgttt
      241 gtttggtcct gcttcaaatt cacgcaggat cctggcatcc aactgttctc tggtgagtgc
      301 aggcttcaga tccagatatg cggacagttc gccgtttggt gcttttgcca gttttgcacc
      361 gatgtgggca ctggcggaga ggatcattgg acctgtgact ccgaaatggg tgaacatcat
      421 ctctccgaaa tcctcgtaaa gtactttttt tccattcttt atggtaagtc ctgtattctt
      481 aagggaaagt ccctgaagct tagggatata gtcttctttt gtctttaatg ggacaaggga
      541 aggagcaatg tctgtgactt tcagtcccag ttctcttgca aaacggtatc cgtcacctgt
      601 ggagcctgta ctctgataag agaatccgcc ggttgccacg atgactgcat cgccttccat
      661 gaaggttccg tctgtaagga tgactcctgt gatcttctcc tgcggtatgt caggtgattt
      721 ttttcctttt ctgccttttc ctgcagcaaa tcctgattct gttaatgcgg cttctgattc
      781 caaggtattt gctgaatctg ttacaggttt ctttacaatt tcctgtacag cagtgtgaag
      841 atgaatcttt gctcctgctt tcttcagctc acgctccaga gcgcggatga tgtctgaaga
      901 atggtcagac tgtgggaata ctctgtttcc acgctctacc ttcagaggga cacctgcttt
      961 ctcaaagaac tccattacat cctgaggggt aaatgaatag aaactgctgt agaggaactt
     1021 gggattgctc atcattgcag gaaagagttc ttctgtgtcg caggcatttg tcacattgca
     1081 tctgcctttt cctgtgatga agactttctt tcccagtttc tcgttcttct ctaatatatg
     1141 aacttcatga tggttacggg ctgcaaaaac ccctgccatc attccggcgg ctccgccgcc
     1201 gattattata actttgctca tggaatattc tcctgtattt attttaccct gcagattgtc
     1261 tatttcatca tggttccacg tcttcgcttc gctacgatca atatagatat gtacctctgg
     1321 cagcatatac ccattggcac attatattcc cgggtatcat attctttcat aataacgcaa
     1381 aggagcctgc ttgcgcaagc tccttttttc atttggacat atttaattac tgatcaatta
     1441 tacaggatat gctccgttct ttttgtcagc tgctttctcg tcaacttttg ttttctgagc
     1501 ctgacggtat ttgaagaagt ccatagctac ctgtgggaac agtgcgtatg ttaatacgtc
     1561 ttcatcctgt tccttgtact gagccatttc gctctcaagt ttctcaagct cgttgtcaag
     1621 aaggtctgcc ggacggcatg tgatcggttt ctcatcgccg atgcacttct tctgtacttc
     1681 cggattaaac ggttttacag ttgcgccgta ttttcctaac aggatatctt ttgtttcttt
     1741 tgtaaccatt ttgtatctct cgcccataag tacgttgaat acagcctgtg taccaacgat
     1801 ctgagaagac ggagtaacaa gcggcggttc accaaggtct ttacgtacac gcggaacttc
     1861 ctcgagaaca tcgtagaatt tgtcttctgc gtgctgttct tttaactggg aagtcaggtt
     1921 ggagagcata ccgcccggta cctggtacag taaagttttg atgttaacac caaggttctt
     1981 cggattgagc agtccgctgt caagagcttc gtcacggatc ggacggaagt agtcagcgat
     2041 ctcggagaga agcttctgat caaatcctgt gtcgtatggt gtatccttga atgtctcaac
     2101 cataacctct gttgcaggct gggatgttcc cagtgcaaat ggagacattg ctgtatcgat
     2161 gatatccaca cctgcttcta ctgcttttaa gtaagtcatg gaagctacac ctgaggtgta
     2221 atgtgtatga aggtcgatcg ggatcttaac tgtttctttt aatgctgtaa caagctctgt
     2281 agctttgttt ggaaggagaa gacctgccat atctttgata cagatggaat cagcgcccat
     2341 atcttcaata cgttttgcaa tgtctgtcca gtattccagt gtgtaagcat ctcctaatgt
     2401 gtaggaaaga gctacctgtg catgagcctt ctctttgttt gcagcgctta ctgctgtctg
     2461 caggttacga aggtcattga ggcagtcaaa aatacggatg atgtcgattc cgtttgcagc
     2521 agatttctgt acgaagtatt ctacaacgtc atctgcgtat ggacggtatc caaggatgtt
     2581 ctgtccacgg aaaagcatct gaagttttgt gtttttgaag ccgtcacgta atttacgaag
     2641 tctttcccat ggatcttcgt ggaggaaacg aagggatgca tcgaatgttg caccacccca
     2701 gcactctact gcgtgatagc cgactttatc aagtttatct acgatcggaa gcatctgttc
     2761 tgtggtcata cgtgttgcga tctgggactg atgagcatca cggagaatgg tttccacaat
     2821 tttaacaggt tttttctcta attctgccat tattaaatct cctttatagt tctgtttaat
     2881 cggatattcg caatccgctt cgctacttgc tcataaccaa atagctgctc cgcagcttat
     2941 cagaaggagt tgcactcctc ctgatacaag caagatagct tgcttgattt ggttatactc
     3001 cgaaaatagc catgaatgtt ccggctgcta cggctgtacc gataacaccg gcaacgttcg
     3061 ggcccattgc gtgcatcaga aggaagtttg taggatctgc ctctgcaccc actttctggg
     3121 atacacgggc tgccataggt actgcggata cacctgcgga accgatcagc gggttgatct
     3181 ttccatgagt cagtttgcag agcagtttac caagcataca tccgccgaat gtaccgattg
     3241 cgaatgcaac aagacctaaa actacgatct tcagagtatc tgcgtttaag aatgcttctg
     3301 cacttgtgga agcacctacg gatgtaccca gaaggataac tacgatatac atcagggcat
     3361 tggatgctgt ttctgtcagc tgttttacaa caccgcactc tctgaacagg ttaccaagca
     3421 tgagcatacc aaccagcgga gctgttgtag gcaggatcag gcagacaacg attgtgataa
     3481 cgatcgggaa caggatcttc tccagtttgg aaaccgggcg aagctgatcc attttgatct
     3541 tacgttcttt ctctgttgtg cagagtttca tgataggcgg ctggatgatc ggaaccagtg
     3601 acatatagga atatgctgcc actgcgatcg gtcccatcag tgcagactgt ccaagtttac
     3661 ctgcaaggaa aatggaagtc gggccgtcag caccaccgat gatggagata gctgccgctg
     3721 cttttccgtt gaatccaagg aagattgcaa ggaagtaagc tgcatagata ccaagctgtg
     3781 ctgcagcacc catcaggaag ctgatcgggt ttgcgatcag cggaccgaag tctgtcatgg
     3841 cacctacacc catgaagatc agggatggta agatactcca ctcatcaagg atgtagaaat
     3901 aatgaagaag tccacctaca ccattagaca tatcttccgg gtttgccata atgtccggat
     3961 agatatttac aagcagcata ccgaatgcga taggaacaag cagaagcggc tcgaatccct
     4021 tcttgatagc aaggtaaagg aatacgcagg ctactgcgat catcaggtaa ttgccccatg
     4081 tcaaactgaa gaatgctgtc tgatgaatca ggttggacaa tgtttctgtt acataagaca
     4141 tttgactacc tcccgtctta gttcattgtt gctaaagtat ctccgttttc tacagaggca
     4201 ccttctgcaa catcaatgct tgcgatagta ccatcctgag gagctactac agggatttcc
     4261 attttcatgg attcaagaat aactacgctg tctccggctt ttactgcctg tccaacgctt
     4321 gctgctactt tgacaacttt accaggtacg gaagcagtta cttttactgc gccggcgcct
     4381 gctgcaggag ctgctgcttt cggagctgct gcaggtgcag ccttaggtgc tgcttttgga
     4441 gctgctgcag gagcggatac gcttcctgtt tcttcaacag ttacttcata tgctgtacca
     4501 tttactgtaa ttgtatagct tttcatttta aaatcctcct aaataaatga caattatctt
     4561 ctatttcttt ttactttacg gatggaacga actacgaagc cgtctgttgt agttccttct
     4621 gctgctgcga tggctgctgc gataacagct accagctctc cgtcatctgc aaggttctct
     4681 tctgcctgtg caggtgctgt ctgtgcgatg gctgctgcct ctgcctcttt tgcagctttg
     4741 gctgcttttg cttctgctgc tttctttgct tccggattcg gaataaatct gaacagagaa
     4801 atcagaaggc ttaataaaat cagcattacg aatacagttc caatacccat cagagtatta
     4861 agacctgctc tctgaagagt cttgcccata ccatactgta catctacaga catggaagtc
     4921 ggtgttccct gtgagtcaaa gacatataca aagtttgctt ctgctttctc aaatttaaga
     4981 ggaacagtaa ctgtgtactg atcatctttg aaagttacag tggtttcacc attgctgtcc
     5041 ttctttgcgc caagttcatc cttggatgtc tgccaggact gcatggcact tgttgtaaag
     5101 tcatctcctg aactcatgta attctcgatt tcttcatctt taagctggac aatggcatct
     5161 gtcagtcctt ctgctgtagt taccagtgtg gacttaacag tatcatcaac cttatctgcg
     5221 gcaaatacca cagaggtgct gccgatcacc agcgcagcca ttacgagaaa tgtcatgaat
     5281 acagaagtta tttttttgat cattttcata tgcgtcaccc cgcttagacc gttccatgtt
     5341 tcttagacgg acgatcttct ctctttgtga acagcatctc aaatgcaccg attacatatt
     5401 ttcttgtgtc agccgggctg atcacagtgt caacatagcc tcttgctgct gcggaagcaa
     5461 caccattctg aagctctctg tactgagcag ctttttcatt cagttcagca gcatctgcat
     5521 ctgcatacat gatcttggct gccagggaag catccatcat accgatttct gcgttatccc
     5581 atgcatatac aaggtctgca ccgatagatt tgctgttcat tgccacgtaa gctgtaccgt
     5641 aagctttgcc gatgatcaca tttaccttcg gaacagttgc atctgcgaat gcagctacca
     5701 gttcacctac ggatttcgcc atcatcttct cgctgcataa ggttgccatg aagcctgttg
     5761 cgtttgtaag tgtaagtacc ggaatatcaa aagcgtcgca gaatttcacg aaatctgctg
     5821 cttttcttgc gcctcttgca gagatgcttc cgtcaaatgt ttctgctttc ttaccttctg
     5881 cgtcatatac ttcgcttctg tttgcaacag cacctactgt agcgccgttt aaacggataa
     5941 agcctgtaac catgtctttt gcatagtctg cttttgtctc gaagaattca ccgttgtcag
     6001 cgatctggga aagtgcgatt gctgtgtcac ctgcacagtt tgcaagatct gcgcatacgc
     6061 ggttaagatc atctgtacac tctgtgtaat tgtctgtgtc ttcattatta gaaggaagaa
     6121 gtgatactaa agaacggatc tggccaagaa tctcatcctc tgtaccaacg ccatcgatca
     6181 cacctgtctc tttgctctgg aaatcagctg ctgctgtgtc acatttgtct gtgttgtttc
     6241 cttccagtgc gtttggtgtg ttgacgaaca tttttccttt tttggattcc atgaatgtga
     6301 aatctgtcag ggacgggata actgccatac caccgccgca tgttccgaag attgctgtga
     6361 tctgcgggat cacaccggat gccagtgtct gtttcagata gatctgtccg aaagcttcca
     6421 gtgcgtctgt tgcttcctga agacggatac ctgcacagtc aacaagtccg ataaccggag
     6481 cgcctgtttt catggcaaga tcataaagtc ttgtgatctt ctttgcatgc atttcaccaa
     6541 cagtaccgtt taatacagat gcatcctggc tgtatacata aaccagtttg tcatcgatca
     6601 caccatatcc ggtgataaca ccgtcagatg gtgccttgtt tgcagtcatg ttgaaatctg
     6661 tggatctggc tgttacaccc tgtccgattt cgacaaaact gtttgcgtca agcaaagaag
     6721 taattcttgt gcctgctaag ctttgtgttg cattactcat tcttgtttgc cctccatctt
     6781 tatgagaata tttaaaagtt aacccaaaaa tttagccgat tttaatttta ccttttccgg
     6841 cagaaaattt caacatttat ttgtcatttt cgttaaaaat atagcagaaa aatttgtcag
     6901 gtttctccaa attttgtttt tttgagcatt tcttcctatt taatagaggg tattacggtt
     6961 attttgtatt gtcccgtatt tcaccctctc ccgcaaacca gtgtatcgac aagttgattt
     7021 ctcgaacaat cctgcgtctg aatttcttat ttctatcctg caagattgtt tcaagaatca
     7081 acttgccggc acaccagagc gtgtttgagg tgactatacc actcacttgt ctgagaatcc
     7141 gactgcacaa gtataaaagt ctcagcgcag ctcggtgaaa aaatgctata gtcatacagg
     7201 ttcagcagga ttttcccatg ctgtggatgc agttgcgaat gctttcattc agtacgcgga
     7261 cagtgcacgg aaaaccatag atgtttttta ttatatagca cgaattatca attagattta
     7321 cggattatcc cgttatataa ttaacacatc aaagaaattc aggccacagc taaagcactg
     7381 aacagctata gatacaacag aaaatttcag gaggaaagac gtaatgaaaa gcaattacca
     7441 gcatattttn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc aacagaaaat
     7561 ttcaggagga aagacgtaat gaaaagcaat taccagcata ttttcacacc actcacagta
     7621 aaaaatatga ctatcaaaaa ccgtatcgtt atgatgccta tgggaaccaa ttacggggaa
     7681 cagaacggcg aaatgagttt tcttcacatt aattattata aagagcgtgc caaaggcggc
     7741 acaggtctga tcatcgtaga gaatgcaagc gtagattctc cgcagggttc caacggaact
     7801 actcagcttc gtattgacca cgacaactat ctgccgcgtc tgtacaaatt ctgtgaagag
     7861 atccacaaat atggtacctg tattgcgatc cagatcaacc acgcaggtgc ttccgctgtt
     7921 tccgcacgta caaatatgca gccggtttcc gcatctgatg ttccgtccaa agaaggcgga
     7981 gaaatcccgc gtccgttatc agtggaagaa atccatcaca ttgtaaagaa atacggcgag
     8041 gctgcaaaga gagcccaggc tgcaggtttt gacgcagtag aaatccatgc gggacattcc
     8101 tatctgatca gccagttcct ctctcctctt acaaacaaac gtacagatga gttcggcgga
     8161 tctgtggaaa acagaacacg tttctgccgt atggtcattg aggaagtaag aaaacaggtc
     8221 ggacctttct tcccgatcat gctccgtctc agcgcagatg agctgatgga aggcggcaac
     8281 actcttgagg atactcttga atatctggaa tatattcagg atgaagttga tatcttcgat
     8341 gtttcctgcg gtttaaacgg ttctatccag tatcagatcg atgccaacta catgaaagac
     8401 ggatggcgtt cctatatgcc taaagctgtc agagagaaat tcggcaaacc atgtatctcc
     8461 atgggaaata tccgtaaccc aaaggttgcc gagcagatcc tcgctgacgg cgatgcagac
     8521 ctgatcggta tgggacgtgg tcttatcgca gaacctgcat gggtaaacaa agtagctaca
     8581 ggcagagaat gtgaccttcg caaatgtatc tcctgtaaca tcggatgtgc aggaaacaga
     8641 atcggcttta accgtccgat ccgctgtact gtaaacccgg ctgttctgga aggtgatgtt
     8701 tataagaatc agaaagtgaa caaaaactgt aatgttgtag taatcggagg cggtactgcc
     8761 ggactggaag ctgcctgtac agccgcagaa gtaggctgta ataccttcct cctggaaaaa
     8821 ggtgagactc ttggcggtct tgcttctgtg atctctaaga ttcctgcaaa gaagcgtctg
     8881 gctgatttcc cgaactatct gattcacaga gcagagcagc ttgagaatct ttatatcttc
     8941 acaaacacag aaggaacacc ggaaaatatc cgcaagttcc atccgaacct gatcgtaagc
     9001 tccacaggtt ccgcaccact gcttcctccg atcaggggac ttcacgaccg cattgacaaa
     9061 gaaggcagta aggttgcttc tatcctggga atgatcaatc acatcaatga ctatccggaa
     9121 gatatgacag gcaagaaggt tgttgttgtg ggcggcggtg ctgttggtct tgatgttgtg
     9181 gaattctttg cagcaagaaa tgctgagatt tctattgtgg agatgatgga tcagatcgga
     9241 cgtgacctgg atcctgttac aaagaatgac atgaaggacc agatgaagaa acatcatgtg
     9301 gcccagctta caaagacagc tcttcaggaa gtaaaagaca gctctttcct tgtaaaagat
     9361 gcagaaggtg aacgtgagct tccatttgac tacggattcg tatgtcttgg tatgagagct
     9421 cagggacagc ttttcgcaga gctttccgat gcttttgttt ctgatgatgt tgagatcctg
     9481 aacatcggag acagcaaacg tgcaagaaga atcatcgacg gaactctgga aggaagaaat
     9541 atccttaata cactgactca gatgggatac ctttaataaa aacctttaca acaaaatacg
     9601 aaaggggata ttataatggc tgaaagaatt accggacata ctgaattaat cggtctgatg
     9661 gcttacccga tccgtcactc cagctctcct gcaatgcaga atgaggcttt tgcaaaactc
     9721 gggtatgact acgcttacct tgctttcgag gttggcgcag atgaaattga ggatgcagta
     9781 aaagcaatcc gtactctgaa aatgagagga tccaatgttt ccatgccaaa caaaactctg
     9841 gttggaaaat acctggatga gctttctcct gcagcagaat tatgcggtgc agttaacacg
     9901 attgtaaatg acaacggtca tcttacaggt catatcactg acggtatcgg atttatgtct
     9961 gccctgaaag ataatgatat tgatgtgatc ggaaagaaaa tgactatcgt cggtgcaggc
    10021 ggtgctgcca ctgctatcga gatccaggct gctttggacg gcgttgctga gatcacaatc
    10081 tttaaccgca aggatgaatt ctgggatcgt gcagtatcca cagtagagaa gatcaataca
    10141 aagacatcct gccatgcagt tctttatgat ctggcagatc ttgataaact gaaagctgag
    10201 atggatgaca gttttatctt tgtcaatgct acaggtgtgg gaatgaaacc actggaagga
    10261 cagtccgttg ttccggacaa atcttacttc cgtcctgagc tgatcgttat tgatgttcct
    10321 tactctccgc tggaaacaaa gatgcgttcc atggccaagg aagttggatg taagactatg
    10381 aatggtctgg gaatgatgtt attccagggt tccgctgcat ttgagttatg gacaggcgaa
    10441 ccaatgccta tcgaacatat gaaagagatt cttcacatct cctatgatga ctgataccnn
    10501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    10561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnngg aaaaacaaaa acagacattc
    10621 tcgaagaagc caaaaagatc actactcttc ctgttgatgt agttgagtgg cgtgtagact
    10681 ggtttgatga tgtctttgct actaagaaag tattagaaac cgctaaagag cttcaggaag
    10741 ttttaaaaga tatccctgtt cttcttacat tccgtacttc caaagagggc ggggaaaaag
    10801 agatttctgt aagtgattac gctgctttaa atatcgcagc tgctcagagc ggttatgtag
    10861 atttaatcga tgtagaagca tttacaggcg atgatattgt aaaaacgatc attgacgctg
    10921 ctcacgaggc aggtgtgaag gtaattgctt ccaaccatga tttctttaag actcctgaga
    10981 aggaggagat tatcagacgt cttcgtatga tgcaggattt cggtgctgat attccgaaaa
    11041 tggctgttat gccgacctgc aaacaggatg ttcttacact cctctctgct actctggaaa
    11101 tgtctgagaa atatgcagac cgcccgatca ttaccatgtc catggcagga acaggcgttg
    11161 taagccgtct gacaggtgag acattcggct ccgctctcac tttcggtgct gcttccaaag
    11221 cttctgctcc gggacaggtc ggtgtgcatg aattaaaaca ggtgctggat atcattcaca
    11281 gcagtctgtg atctgttgat gaatgatgtg atatcagatg ttattcttgc ctatagctga
    11341 tatcactcat attcgtcaac agattgttac agaatttgaa tttaataatt atgactcctt
    11401 aaaataataa ttgatgaaaa ccaagaagaa cagccccgaa tcccggctgt tcttcttggt
    11461 ttttgcttat attatttttt ctcaagggga ttccagttgg acaggaagat attcagtccg
    11521 aagccaactg ccagtgccca tgcagatgcc catgcggttc cctgggttgc gaggactgct
    11581 gccattacgc ctgcgatcat cttgtctctg tcgctcttgc agtaatccat accgattctt
    11641 gcacatacaa acgcctggaa catcagagta atggaagatc ctactccgaa gatcggacgg
    11701 aagaagctta ctacaggaat gatcagcaca cttaagaatg tggccagtct gaaagaagcc
    11761 atccctccga gaagggactt catagctttc tttccttctt tgtaacgcat ggatacggat
    11821 acagtcattc caacccataa cggaccggaa aggggaggaa atggtgcaat gatggacagg
    11881 atcaggtttc tcagaccgct taccagattg gaacggctgg aattgaaatc aatatactca
    11941 tcatctcttg cctgacgtgc ctctgataca agggtctctg tagtgacaaa atcaccaaat
    12001 gcaataacat agcacaccag cgccagcggc aatgctttga taaacataga tgcaggagga
    12061 atccctacgc cgaaaatact cacctgatca atgatatctt tgaactgagg aatcttgata
    12121 aaggtaccaa tctccagtcc cggggcatcc agttcgccaa ccagaagtcc tactaccatt
    12181 gcgataagat aggggaaaag atttccgtat ctcgcaacaa gatcaagaaa cttatttgtt
    12241 tttctcttct cctgatattt gtcagagaag ctgatcagga tcaaaagacc tacacctgca
    12301 acaatagcca gaggatattt gtgcatattt ccgttctctc ccagctgtcc tgccataact
    12361 gtaactggtg ctgcaagaag aattccgcct ttgacagaat tgggaactgc atgaacaaat
    12421 ttatccgcca gtctggtcac acccataaag ataaatacca gacctaccag catctgcagt
    12481 gcgatcatag cctgtattcg ctcttttccc atagggaagc cttccagaaa tacaatagtc
    12541 aacggcaatg tgggtgtgat ccaccccggt actaccggat cgccgagcag gctgtgaagc
    12601 agataaagga aggtttcaat aattacacag ctccacgcca gctcataagg aagccccaga
    12661 tattgctcca gatagggaac agctgccagt gctgttacgc ccaggatcag accctgaatg
    12721 aactcaacag attctatctt gtagtgtatg aatggaagtc ttatctgaaa tggtccaaag
    12781 gggatgtagg gcagttcatt ttctcttctt tgtgttcttg tatnnnnnnn nnnnnnnnnn
    12841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12901 nnnnnnnnnn nnnnnnnnnn nnnatttctg ttcttcttta caaagagggc gagcaggata
    12961 ccgacgatgg tcactgccat gttcagaaga agaatcattc tcggagcact gcttccgcca
    13021 actttggtaa tgtaccctgc aaggcttaag attgtgtagt tcgcgatgct ggatgcgatc
    13081 attaccagtg atgttgctgt tcccttattc tcagggaaga actctgctgt ggtggaaact
    13141 gccagctgga gaacaccgcc tgcacctgca tatccgatca caaagccacc tatcaggcaa
    13201 ataaacggag cctggataaa gtagcagagg accagcatga ttgtggaaat taacggatag
    13261 atgatcagga cgttaatctc tttcagacct tttttgataa aagctgctgt tgcaaggatg
    13321 gcagttgcag ttcccagggc atacagggac tggatctttg aagggtctgc cataccatag
    13381 gaacgggcaa gttcctgatt acagttcagc cataacataa aggttgagga gctggtgaat
    13441 ccgatcagga ttgcagcaat cgctgcaggg gaaatcttgt gtccggattt cttcttatca
    13501 gctttagcct gtactgcctt ctctctcgcc ggaaagggga ggaccagaat taggattccg
    13561 tcaatgagga ttgcaatacc tgctacaata aagattgtct tatatgacat atttgcagat
    13621 gctacgattc cgatcaggaa tggaagcaga aactgactca ggcagatgga aaattttgta
    13681 aacaggttgg ctactgacgg gttgtttaca tagatttcca tacaggtagg gcttacgcag
    13741 gtatcgagga aagagttcgc gattccgccg atcactgcaa aggcatatcc cattgccatg
    13801 gatgtggaat ttgccattcc aaagaagtat gctacataac agagcacacc gataattccg
    13861 ctcagttttc ttccgtattt gtcagacaga ggaccggaga aaggaagaga aatcagacgc
    13921 cccagtccaa gtgctgcaat tacagatact accatactta catccagtgt gccatcggcc
    13981 aggggcttcg caccccaggc agctgcaaac tccggtttgt actgccccag gatagaagca
    14041 ccgattccat ggatgaaata ggtgaaatat gctgcaaggg aggtgaaaat gagcatttta
    14101 tttgttttct gtttcatttt ggtctcctag gttattatta cttgttttcg ttttcttcct
    14161 ggaatttctg gtattcagct gttggcattt ccagtcctgt gtagagtttg taagctgcag
    14221 ctccctgcca taacagcatt ccttttccgc cgattgcaag cttgcagcct gcttctttgg
    14281 cttcttttac cattcttgtt tcagcaggat tgtaaacaac gtctgctact acaaggtcag
    14341 ggcggaacat ggatttatct ttgatcagag taagctcttc gtgaggtttc attcctgcaa
    14401 gtgttgcgtt tacgaggatg tctgcgtttg caacctcttc tttcagtttt gcctcatctg
    14461 ccagatcaaa tacagaaact ttacaatccg gtgtttcttt gctcagtttc tctgctgtgg
    14521 actctgcacg tgcaaagaat gggtctttcg gattgaagat agaaatggat tctgcaccgt
    14581 ctaatgcaca ctgtacctgg attgctgttg cagcaccgcc tgcaccgaga actaccattt
    14641 ttttgccttt tacgtcaacg ccatgttctt ttaagttgcg gacaaatccg ataccgtctg
    14701 tgatatgtcc tactaatttg ccgttttcat taacgattgt gttaactgca ccgatgattc
    14761 ttgctgcagg tgaaagctca tccatgtgtt ttgcaacttc gttcttgcat ggcatagtta
    14821 cgtttgcgcc tctcattttg aaaagacgga ttgcatccag agcagccgga acctggtctt
    14881 ccttgatgtc aaacgccatg taagcataat caaggttgtg ataacggaag ctgaagttat
    14941 acattgccgg tgatcctgag tgtcctaccg ggcttccgat aagtgccatt aatcctgttg
    15001 ttcctttaat tctctgttcc atttcctgtt tgcctcctga atttttttgt aaaatcattt
    15061 tcaagctgct gtccgctgat aatatcatac agcgtctctt aactgcaact ataaaacgaa
    15121 taaattataa gattcgaaat tcgctgattt actgcgtaaa tcgctgcttt ctcatgtttg
    15181 gcgggtccca ggttcaaaaa tcttatcgtg caagcacgaa cgactttttg aacttttgac
    15241 cctgatatca tcacaatgtg gaagctacct catacgcttc tttcgtagca tcaagtgctc
    15301 ttcttgcgcg ggtggcatcg ccaatcacat aggtatccgg tacgatagct ttgatctctt
    15361 cgccgaatgg gttgtagttt ctgaatccca tggaaaggat gacagaatca tatcctctgg
    15421 attcatgtct ctgtccgtct gctgtctcgt actctacgcc gtcctcatag aatttgcata
    15481 cctttgcacc tgtgatctct ttgatcttgt aatcttcgaa atctttcatc aggtaaactc
    15541 tatgctcgtg gatcacgtcg gcacctacag tgtctctgaa ctcaatgact gttacatcat
    15601 ggttctgctc accgaggaat gctgctgtct cgcatcccac cattccgcca cctacaacca
    15661 gtactttctt tcctgctgct ctctttccgt caaggagatc agagccatgg ataattgcag
    15721 gattgtcgat accttcgatc ggaaggatca gtgttctgga accggaagca acaattacgc
    15781 tgtctggttt ctcttccctg ataagatcca gagttacttc ctgattcatt ttaattgtta
    15841 cgcctgcttt ctggcagcgt acgatatagc tgcggatcat gtttgtgatg tcgccttttc
    15901 ccggaggata agcagcaaga cgcatgtttc cgccaagttt atcacttgct tcataaagtg
    15961 ttacctgatg acctttttcc tgtgcgataa atgcagcgca aagacctgca acaccgccgc
    16021 cgattaccat tactttctta gctttttctg caggagcaat gccctcagct tcatgtccaa
    16081 ggaatgggtt tacaagacag catacagggt ttcctgcata catgtttgcc acgcagccct
    16141 gaagacatgc gatacatggg atcatatcct ccagtctttc ttcctgcgct tttaatggca
    16201 tataaggatc tgcaaggctc tgacgtccga atgcaaccag gtcacagcgt ccttctttta
    16261 ccattaattc cgcaaactgc ggttctgtat aacgtcctac tgtgatcacc gggatagata
    16321 cggcacgttt aatctcttct acctgagaag cggagaaacc gccgtgtgta actgtcggtg
    16381 cccacataaa ttcatcgcgg atgtgaacag ctctggatac atggatggca tccagtccgc
    16441 atccttccag atatgcagcg atcgcagcac tgtcatgcac atcaagaccg cccggtactt
    16501 catcacagct gttgattctt gcaagaactg cgatctttcc ttctgtcatc ttcttaactt
    16561 cttcgatgat cagacgggag aaacgcattc tgttctcaaa ggaaccacca aattcgtcca
    16621 gtctcttgtt tgttctcgga gaaaggaagg tgcttaccag atagccgtgt gccatatgga
    16681 tctcaactgc atctacgcct gcttccatgg ctctctttgc tgcgaggcca tagcctttta
    16741 ccagttcata aacttcttca
//
