LOCUS       c00041_gnlPro..        15477 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LHOKEKIH_41.
ACCESSION   c00041_gnlPro..
VERSION     c00041_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 02:24:59
            Original ID  :: gnl|Prokka|LHOKEKIH_41
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15477
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15477
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2228:5477]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2229..5477
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..15477
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15477
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(111..989)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_1"
                     /sec_met_domain="CN_hydrolase (E-value: 1.3e-56, bitscore:
                     181.4, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELF
                     ERPYFCQERRYEYYEYAQTAEENPAVRHFSRVAAELGIVIPVSFYEKEVNNTYNSVAVL
                     DADGKNLGIYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGTIGVGICWDQWFPETAR
                     CMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPC
                     PENGMQKSALNFYGSSFITDNTGALCAELPGGEEGVLVSTFDLDALKADRLNWGLFRDR
                     RPEMYAKISGK"
     CDS             complement(946..1149)
                     /locus_tag="ctg41_2"
                     /transl_table=11
                     /translation="LLAVEIFTVSPSRFPEKISDLDAENFESHVFEGYYLKVMKKLTYV
                     NRSRRNRQDEKCNSGSSSDEMQ"
     CDS             complement(1091..2281)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_3"
                     /sec_met_domain="PAD_porph (E-value: 8.8e-129, bitscore:
                     418.9, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRLSDISDTKTLRAGFPDICRAIKEKETDMEVTEKNRTKYRMPGE
                     FEPHEGCVMIWPERPGSWNYGAREAQKAFVKVAEAIGESEKVYMLVSKAQMENAKNQLG
                     NVSGVTLLECETDDAWARDVGATMVLDEKGAVCGVDWQFNAWGGTFDGLYRNWEKDDRV
                     AAFICRTLGCPCLDARPFVLEGGSIHSDGEGTLIVTEACLLSQGRNPQMSREQIEEQLK
                     YWLGVHKIIWLPCGIYQDETNEHVDNVCAFVRPGEVVLAWTEDETDPQYAMSLADLKVL
                     EQETDAKGRKFKIHKLPIPQKPVCLTQEDVDGFVFEEGEDEREAGERMAASYVNFYISN
                     GGIILPQFGDENDKRAVEILQKCFPERRIYPIDARAIIVGGGNIHCITQQIPGKNI"
     CDS             complement(2229..3350)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_4"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 2.3e-15,
                     bitscore: 46.4, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNS
                     TAQLKKFKEVCTGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENEIRTLILDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMHEDGECEVIRHFGYEDFKSRLS"
     CDS             complement(3340..4620)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_5"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 4.6e-44, bitscore:
                     141.1, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 2.2e-36,
                     bitscore: 114.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKE
                     KIESTTKTKIETAKVDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDPTWRAIYEKRCKEKGFTAYFDYSWQWAYDEKFKEAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             complement(4617..5477)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_6"
                     /sec_met_domain="Spermine_synth (E-value: 3.7e-54,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 5.5e-16,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             complement(5480..6937)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_7"
                     /sec_met_domain="OKR_DC_1_C (E-value: 3e-14, bitscore:
                     43.2, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 6.6e-127,
                     bitscore: 413.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLG
                     EKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVC
                     KAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDA
                     VAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMA
                     AVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRG
                     EESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEV
                     YDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEY
                     IAPAVVASPQQAFYAEKESLPMEQAAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYIL
                     YARDKGCSMQGMEDPKVEYLQVLKGGI"
     CDS             8226..9911
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTHFS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_8"
                     /sec_met_domain="FTHFS (E-value: 5.3e-276, bitscore: 905.7,
                     seeds: 408, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFKSDIEIAQECEMLPITQIAEKAGIDDKYLEQYGKYKAKIDYN
                     LLKESDKKDGKLILVTAINPTPAGEGKTTTTVGLADGMQRLGKSVMVALREPSLGPVFG
                     VKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMIDNHIFQGNALNIDPRKIT
                     WRRCVDMNDRQLRNVVDGLGGKTNGMPREDGYDITVASEIMAVLCLASDIKDLKERLSK
                     IIIGYTYGKVSEQKPVTAGDLHAEGAMTALLKDALKPNLVQTLEHVPAIVHGGPFANIA
                     HGCNSVTATKMAMKLADYAITEAGFGADLGAEKFLDIKCRMAGLKPSAVVIVATVRALK
                     YNGGVAKADLNNENLEALEKGIPNLLKHVSNIKNVYKLPCVVAINAFPTDTKAELDFVE
                     AKCKELGVNVALSEVWAKGGEGGIKLAEEVIRLVEEPNDFSYAYELEGSIEDKLNQIVQ
                     KVYGGKKVVLTANAQKQAKQLEALGFGNCPICVAKTQYSLTDDQTKLGAPTDFEVTVRN
                     LKISAGAGFIVALTGEIMTMPGLPKVPAAERIDVDETGKITGLF"
     CDS             complement(10020..11444)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FumaraseC_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_9"
                     /sec_met_domain="Lyase_1 (E-value: 2.8e-95, bitscore:
                     308.9, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="FumaraseC_C (E-value: 1.1e-22, bitscore:
                     70.1, seeds: 737, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTDYRVERDSIGVKDIPEDVYYGVQSLRAAENFHITGLNMHPE
                     IINSLAYIKKAAAITNCEVGLLEKKKAQAIVQACDEIVSGKFHNEFIVDPVQGGAGTSL
                     NMNANEVIANRAIEILGGKKGDYTIINPNDDVNCGQSTNDVIPTAGKMTSLRLLQNLKK
                     QLLRLYDALNEKATEFDHIIKMGRTQMQDAVPIRLGQEFKAYSVAIMRDIHRMDKAMDE
                     MRTLNMGGTAIGTGINADEGYLRRIVPNLTEISGMDFIQAFDLIDSTQNLDPFVAVSGA
                     VKACAVTLSKMSNDLRLMSSGPRTGFGEINLPAKQNGSSIMPGKVNPVIPEVVNQVAFN
                     IIGNDVTITMAAEAGQLELNAFEPIIFYCMFQSIDTLGYAVQTLVDNCIVGITANEERC
                     RYLVENSVGIITAISPHLGYQKAADIAKKAIKTGESVRSLILKEKLMDEDELNRILDPI
                     HMTEPGISGKDYLIKK"
     CDS             11560..12495
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     58; E-value: 2.3e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg41_10"
                     /sec_met_domain="LysR_substrate (E-value: 3.9e-34,
                     bitscore: 107.5, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 4.4e-19, bitscore: 58.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQGMEYIYEVYKEKSFSKAAAALFISQPSLSANVKRVENRIGYP
                     IFDRSTKPLQLTEVGKHYIQAVEKVMDIENNLENYLLDLGNLKTGTLNVGGSNFFSSWI
                     LPPLIADFSQKFPHVQISLVEESTAKLSQFLQAGKLDLVIDNCILDNQIFERYIYQKEQ
                     LLLAVPKNYSVNTRLQKYQIPIEEIRNGQFRSSHIPSVPLNKFENEPFIILRSDNDTGK
                     RALTICQENHFSPSVVFRLDQQMTAYNIACLGMGITFIGDLLLSRVPTNSELVFYKLPG
                     QSSKRTVFFYWKKGRYISRAMEEFLKLPFS"
     CDS             complement(12607..14064)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_11"
                     /sec_met_domain="FGGY_C (E-value: 8.1e-39, bitscore: 123.0,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 5.1e-81, bitscore: 261.4,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYYIGIDLGTSAVKLLLMEESGKICNIVSREYPLFFPHPGWSEQK
                     PEDWFAQSMEGMKELTKDIDRAQVAGIGFGGQMHGLVTLDKDDNVIRPAILWNDGRTGE
                     ETEYLNTVIGKDKLSQYTANIAFAGFTAPKILWMQKNEPENFKKVVKIMLPKDYLAYRL
                     SGSFCTDVSDASGMLLLDVKNRCWSKEMLEICGITEEQLPKLYESWEVVGTLKPEIAKE
                     LGFSENVKVVAGAGDNAAAAVGTGTVGDGQCNISLGTSGTVFISSKNFGVDENNALHSF
                     CHADGSYHLMGCMLSAASCNKWWAEEILQTKDFAAEQAPIQKLGENHVFFLPYLMGERS
                     PHNNPDARGVFFGMSMDSTRADMTQAVLEGVAFGLRDSLEVARNLGIKIERTKICGGGA
                     KSPLWKKIIANVMNLKVDVLENEEGPSMGGAMLAAVGCGAYPDVETIGKKFAKVVDTVE
                     PDPELVAKYEERYQKFRTLYPAMKPLF"
ORIGIN
        1 ataccgcagg tagcaactaa tataatcata aactttttat gaaattctta taaacacata
       61 tatcgttttg gaaataacac tgcaaatcca ctcggattct cctgctttcg tcattttccg
      121 gaaatttttg catacatctc cggtctgcgg tctctgaaaa gtccccagtt cagtctgtct
      181 gcctttaatg catccaggtc aaaagtgctt acaagcaccc cctcttcccc tccgggcagt
      241 tctgcacaga gagcacctgt gttgtctgtg ataaaagaag agccgtaaaa attaagagca
      301 gatttctgca ttccgttttc cggacatggc tctactgttt cctcaccgat tctgttggca
      361 gcgatcacag ggatcaggtt ggaggcagcg tgtccctgca tacatcttct ccagtgttcc
      421 atgctgtcac attccaggat gggttcactg ccgatggcag tgggataaaa gagaagctct
      481 gctccctgca gtgccataca tcttgccgtt tccgggaacc actgatccca gcagattcca
      541 actccaatgg ttccaaatct ggtatcaaaa accttaaagc cggtatctcc cggtgtgaaa
      601 tagaattttt cctgataata atggtcatcc ggaatatgtg ttttccgata aatgccgaga
      661 ttctttccat ctgcatccag aaccgcaacg ctgttataag tattattgac ctctttttca
      721 taaaagctga ccggaatcac aatccccaac tctgccgcta ccctgctgaa atgacgcact
      781 gcagggtttt cctctgcagt ctgcgcatat tcataatact catatctgcg ctcctggcag
      841 aaatagggcc gttcaaaaag ctccggcaga agaacaatct cagctccctt tgctgctgcc
      901 tgacgcacca gttcctctgc atgggcaata tttttctcca cacttttact gcatttcatc
      961 tgaactgctg ccactgttac atttctcatc ctgtctgttc ctcctgctcc tgtttacata
     1021 agtaagtttt ttcataactt tcaggtaata accctcaaac acatgactct caaagttttc
     1081 tgcatcaagg tcagatattt tttccgggaa tctgctgggt gatacagtga atatttccac
     1141 cgccaacaat gatggctctg gcatcaatgg gataaatcct tctttcagga aaacacttct
     1201 gcagaatctc cactgccctt ttgtcatttt catccccaaa ttgtggaagg atgatccctc
     1261 cattggaaat atagaaattc acgtaactgg cagccatccg ttctcctgct tcccgttcgt
     1321 cttctccctc ttcaaacaca aagccatcca catcttcctg ggtaaggcag accggtttct
     1381 gaggaatcgg aagcttatga atcttaaatt ttctgccttt tgcatctgtt tcctgttcca
     1441 gcaccttcag atcagccaga gacatggcat actgcggatc tgtctcatcc tctgtccatg
     1501 caagcacaac ctctccgggc cttacaaaag cgcacacgtt atccacatgc tcattggttt
     1561 catcctgata gattccacat ggaagccaga taatcttgtg gacaccgagc cagtacttca
     1621 actgttcctc tatctgttcc ctgctcatct gaggattgcg tccctgactc agaagacagg
     1681 cctctgtaac gatcagagtc ccctctccgt cagaatggat ggaaccgccc tccagcacaa
     1741 aaggtctggc atccagacat ggacaaccga gagtcctgca gataaaggca gccaccctgt
     1801 catccttttc ccagttccgg taaagcccgt caaaggtacc tccccaggca ttaaactgcc
     1861 agtcaactcc acagaccgcc cctttctcat ccagaaccat ggttgctccc acatctctgg
     1921 cccaggcgtc atctgtctcg cattccagca aagtcacacc ggaaacattc ccaagctgat
     1981 tctttgcatt ctccatctga gctttggaaa ccagcatata caccttttcg ctctctccaa
     2041 tagcctctgc aactttcaca aatgctttct gtgcttccct tgccccataa ttccaggaac
     2101 cgggacgttc cggccagatc atcacacatc cctcatgagg ctcaaattct ccgggcatac
     2161 gatattttgt tctgttcttc tctgtaactt ccatgtctgt ctccttttct ttgatagccc
     2221 ggcagatatc aggaaagccg gctcttaaag tcttcgtatc cgaaatgtct gataacctca
     2281 cactctccgt cctcatgcat aaccgcaata tccggcagcg gcataccgtt aaatgtatta
     2341 ttcttcacca tagaataaat cgccatatcc ataaaataca gcttgtcccc gatccggatc
     2401 tctctgtcaa aggaataatc tccgatcaca tctcctgcca ggcaggtgca ggaagataag
     2461 cggtaggtat atgccttctc ccctgcttcc ccgctgtcct taagaggcgg acgatagggc
     2521 atctccagca catccggcat atggcaggct gcagaagcat ccaaaatcag cgttctgatc
     2581 tcattttcca caatgtccat aacctctgtc accagatatc cggcattcag ggcaacagcc
     2641 tccccgggct ccagataaat atccagatca taggtttcct tcatatgctg aatacatttt
     2701 tccaggagct ttacatcata atcctctctg gtaatatgat gtccgccgcc catattcagc
     2761 caggaaacct cagacagaaa ttctccaaac ttctcctcta ccgcctgcaa tgttttctcc
     2821 aggtcatccg cattctgttc gcagagcgta tgaaaatgca gtccgtcgat ccatttcaga
     2881 cattccccgt caaagttctc tctggtaacc cccagccttg aacccggcgc acagggatca
     2941 tagatcgcat gatccccctg agtggagcat tccggattaa tacggagtcc cagactggct
     3001 ccggtacaca cttctttaaa tttcttcagc tgtgctgtgg aattaaagat aatatggtca
     3061 cagatccgat ccagttcctc tatatcttct gtacggtaag caggggaaaa aacatgattc
     3121 tctttcccca tctcttcata tccaagcctt gcctcaaaca gaccgctggc agtggtacct
     3181 gccagatatt ttccgatcat gggatacaga gcaaaaccgg aaaacgcttt ctgcgccaga
     3241 aggatcttac acccggtatc ctcctggact tttttcaaaa tctccagatt ctcccgcatc
     3301 ttcttctcat cgatcacata gcagggagtt tgcagttgat caatcttcat tggctttcca
     3361 gacctttacc agttcaggat cttcgcagac tttccatgga agtccccatt tgttcagtgc
     3421 ttccatatat ggatccggat caaattcttc cacattaaat acacccggct tcttccactg
     3481 tccggtcact accatcatgg aaccgatcat agccggaaca cctgttgtat aggagattgc
     3541 ctgggattcc acctctttat agcattcctg atgatcacat acattataaa tataaatact
     3601 tttctctttt ccgtccttaa cacctgtgaa aatacagccg atatttgttt tacccactgt
     3661 tctcggaccc agagatgcag gatccggcag aagagctttc aaaaactgga tcggcacgat
     3721 ctcctgtcca ttaaattcca caggtgcggt ggaaagcatt cctacatttt ccagacattt
     3781 catatgtgtc agatagctct gtccgaatgt cataaagaaa cggatcctct gtactcccgg
     3841 aatatttttt gccagtgatt caatctcttc atgatgaaga agatacatat ccttctttcc
     3901 tacctcagga aaatcgtaga cagatttaaa ttccataggc tctgtttcta cccaatgtcc
     3961 gtcttcccag taggaaccat ttgcggaaac ctctcgaaga ttgatctccg ggttaaagtt
     4021 tgtggcaaaa ggatatccat gatcaccgcc gttacagtcc agaatatcaa tggtatggat
     4081 ttcatcaaaa taatgcttca aggcataggc actgaataca ctggtaacac ccggatcaaa
     4141 accggttccc agaagagcag tcagtcctgc ttccttaaat ttctcatcat aagcccactg
     4201 ccaggaataa tcgaaatatg cagtaaagcc tttttcttta catctctttt cgtagattgc
     4261 acgccatgtg ggatcttctg tatcctctgc ttcataattg gcagtatcaa tataatccgc
     4321 accggcttcc agacatgcat ccatgatggt aagatcctga tatggaagtg ccacattcag
     4381 gacagcatcc ggcttatagg ctctgatcaa ttctgcgacc tctgctgcat tatccgcatc
     4441 tacctttgct gtctcaattt ttgtcttcgt tgtactttca atcttctctt tgagtgcatc
     4501 gcatttttcc tttgtcctgc ttgcgatcat aatctctgta aaaacatcgc tgttctgaca
     4561 gcatttgcga attgccactg aagctacccc accacatccg attaccaata atctgctcat
     4621 aaactgtttt cctcctcttc cagtaaatct tctacatatt ttggaagcat aaatgctcct
     4681 ctgtgaagat ttgttgtata ataccatgtt tctatattaa gattatcaaa cctctccggc
     4741 ctgaaatctt ccagtggatg atatttcttt gatgcaaatc caaaaagcca gtatcccgag
     4801 ggacaggtag ggatatgtgc ctgataaacc ctgctcaccg gaaatgaccg gaaaaccttt
     4861 ctgtgcatct ttctgcattc cacctcatcc tcatcataaa aaggacttcc atgctgataa
     4921 accatgattc cgtcatctct gagagcctta taacagcttc cgtagaattc ctttgtaaaa
     4981 agtccctctg tatgtcccag cggatctgtg gaatcattga tgatcaggtc atatctggcc
     5041 tttttattcc gcaggaaccg aaggccgtct tcataataaa tgttgactct ctcatccttc
     5101 agtccctggg caatatccgg aaacatctcc gcacatacat ccacaaacat tttatcggat
     5161 tccaccacat caatgctctc aatctgtgga taatggatca gttctctggc aactccaccg
     5221 tcaccgccgc cgatgatcag aacatttttt acattgggat gtactgtcat tggcacatgc
     5281 gtgaccattt catcataaat aaattcatct ttatcagaga atacgatctc accgtccaga
     5341 gccacaaatc ttccaaattc ttcagactca aacacatcga ttctctgaaa ttcactttcc
     5401 cctgaaaata actgtcggtt aatccggaca gaaagcttta catttcctgt atggaactcg
     5461 gaataccata attccatgat cagatacccc ctttcagaac ctgaagatat tctaccttcg
     5521 gatcctccat tccctgcatg gaacagcctt tgtctcttgc ataaagaatg tattctacaa
     5581 tttcctgtgt caccatttcc ccaggagcaa gaatcgggat tcccggagga taacacataa
     5641 caaattcacc gctgatcctg cctgccgcct gttccatggg cagagattct ttctccgcat
     5701 aaaatgcctg ctgtggagac gccaccactg caggtgcgat atattccccg gaaagcatac
     5761 ctgtgctgtc cttcttatac agacgttcaa tatcagccaa tgcccctacc agtctctcaa
     5821 tatcctgaag cctgtctcca atggaaatgt aagccagaat attacagata tctccaaact
     5881 cgatctgaat atcatattca tctctgagaa gatcataaac ttcaatacct gccagcccat
     5941 ttcccagtgt ataaatggag agttttgtaa catcaaaatc aaaaacactg gttccattga
     6001 tcagatccat accatatgca taataaccgc cgatctcatt gatctcctct ctggcatact
     6061 gcgccatccc tgcaaccttt tcaaaggatt cctctcccct gagtgccaga tttcttctgg
     6121 agatatccag actggacaac agaagataag aagcgcttgt ggtctgagtc agattgatga
     6181 tctggcgcac tttctctgca ttcatactct tattcaaaag cagcagcgaa ctctgtgtca
     6241 gacttccgcc ggatttgtgc atggaaactg ccgccatgtc agcacctgcc gccattccgg
     6301 atacaggaag gtttctgccg aaataaagat gggttccatg agcctcatct gccagcacct
     6361 tcattcctct tgcatgagcc ttctttacga tagtccgcag atccgaacag attccataat
     6421 aggtagggtt atttacaaga actgccaccg catccggatt ctcatccata gccttctcca
     6481 cctgactgac ttccatgcca agggaaatgc ccagctgcgc attcacctcc gggtttacat
     6541 aaaccggaat tgcaccgcac agtaccaggg cattgatggc acttttatgt acatttcgcg
     6601 gcagaatgat cttatcccct gccttgcaga cagacaggat catgctctgc actgcagatg
     6661 tggttcctcc taccataagg aatgcatgcg ctgcgccaaa agcatctgct gcaagctcct
     6721 ccgcttctct gatcaccgaa accgggtggc agagattgtc cagcggcttc atagaattaa
     6781 catccagccc cacacatttc tctcccagca actgtgcaag ctccggattt cctcttcctc
     6841 ttttatgtcc cggcacatca aagggaacga ctctcttctt tcggaaacgt tccagtgctt
     6901 catatatggg cgcatgctgt tgtctttcat aatccatttg acatgttcct cttttcctgt
     6961 cgtcatgtac cggcaaatac agttctatca ttcagcaatt gtatactgcc tcaaaccggc
     7021 acaatgattc aattatttct ctatatattc aagtcgaacg catgtgagac acatcctcgc
     7081 aaagcgttta tctccaacca tatcctttat atttgctata tctgcacaaa aaaagaagca
     7141 gataagttca ttcaccatct gcttctctca tgatctatag aatttctcag gctctgtctc
     7201 tttatatact gaccggattt cccgtataaa tccgtctgta tcctgtgcct gttcccgtat
     7261 tctgaaatat tcatgactgc tgtcgtcttc aatcgctggc aaatatatgc tatgctctta
     7321 ttgaccgttt cacaagatga tgtgtgctta cgcactgatt attataaagt aatcaactta
     7381 taaaatttga gcttctaact caatcaataa tgtggtgtct cccacccggc aactgccccg
     7441 cctgtccgta tggcttaaca ttcagaaact gtctctgaat gtgagcaaat atttgcatga
     7501 aaacgatagt gtcttttcat actaaagatg agaataacat atcttctgaa ctgttgtcaa
     7561 ttccattttc catattttgc actagagcgt gtctgaaaaa ggctttctgc aagatgtgcg
     7621 tcacaatttg tgggatattt tgcccggatg agggcgccgt agcgggctac ggcaactgaa
     7681 ttcgggtgaa atatcccgca aagtgggggc gtgcagattg cgggaatgat ttttcagaca
     7741 cgctctagct ttacccgctt tttatatttt cttcatttat cagggaaaac tgtgtttatt
     7801 ttttaacaat ttctttcctt gagaaaacgt attttctttc atgaccaggg attacgattc
     7861 tcttctctta tcaatttgca caacttttat ccagtttact cacatttttt gacgtttcaa
     7921 caaaattttc ttgacatttt tttctcaaaa tgatatattg tattcatcaa ttgaaagaac
     7981 cttcgagtac tgacggaaag agtggagtgc aaaccacgtg gagtcggagg tttgtgggag
     8041 ccgaccgtct gggcagtatt tgaaatattc agatactggc ctttttttat aactttcagg
     8101 gcagaaatca ggaataccag gcagaccggc caatacttct ttcaattaat aattgttgct
     8161 gatcgcggag tgaacagcaa cagaagtttt tcatgttatg cggaaacgaa aggagaaaaa
     8221 caattatggg attcaaatca gacattgaaa ttgcacagga atgcgagatg cttccaatta
     8281 ctcagatcgc agagaaagca ggtattgacg acaaatatct ggagcagtac ggaaaataca
     8341 aagcaaaaat cgactacaat cttctgaaag aaagtgataa gaaggacgga aaattaatcc
     8401 tcgttacagc tatcaaccca actccagcag gagaaggtaa aactactact actgtaggtc
     8461 ttgcagatgg tatgcagaga cttggcaaga gtgttatggt agctcttcgt gagccatcct
     8521 taggaccggt attcggtgta aaaggtggtg cagcaggcgg cggatatgca caggttgttc
     8581 ctatggaaga tattaacctt cacttcacag gtgacttcca tgccattggc gcagctaaca
     8641 acttactggc agctatgatc gataaccata tcttccaggg caatgcatta aacatcgacc
     8701 cacgtaagat cacatggaga agatgtgtag atatgaacga ccgtcagctt cgtaacgtag
     8761 tagatggtct tggcggaaag acaaacggta tgcctcgtga agacggatac gacatcacag
     8821 ttgcatctga gatcatggca gttctctgtc ttgcaagcga catcaaagac ctgaaagaaa
     8881 gattatccaa gatcatcatc ggatatacat acggaaaagt ttccgagcag aaacctgtaa
     8941 cagcaggtga ccttcacgca gaaggcgcta tgacagccct gttaaaagat gctctgaaac
     9001 caaaccttgt acagactctg gaacacgttc ctgcaatcgt acatggcgga ccattcgcaa
     9061 acatcgctca tggatgtaac tctgtaacag ctacaaagat ggctatgaag cttgctgatt
     9121 atgcaatcac agaagctggt ttcggtgctg accttggtgc tgagaaattc cttgatatca
     9181 aatgccgtat ggctggttta aaaccaagcg cagttgtaat cgtagctaca gtacgtgccc
     9241 tgaaatacaa cggcggcgtt gctaaagctg accttaacaa tgaaaacctg gaagctcttg
     9301 aaaaaggtat cccgaacctg ttaaaacacg tttccaacat caaaaacgta tacaaacttc
     9361 catgtgttgt tgctatcaac gcattcccta cagatacaaa agcagagctt gactttgtag
     9421 aagctaaatg taaagaactg ggcgttaacg ttgctctttc tgaagtatgg gcaaaaggcg
     9481 gcgaaggcgg aatcaaactt gcagaagaag ttatccgtct tgttgaagaa ccaaacgact
     9541 tctcctatgc atatgaactg gaaggttcta tcgaagacaa actgaaccag atcgttcaga
     9601 aagtatatgg cggtaagaaa gtagttctga cagctaacgc tcagaaacag gcgaaacagt
     9661 tagaagctct tggctttggc aactgcccga tctgtgtagc taagacacag tacagcttaa
     9721 cagatgacca gactaaactg ggtgctccta ctgacttcga agttacagta cgtaacctga
     9781 agatttccgc tggtgcagga ttcatcgtag ctcttacagg cgagatcatg acaatgccag
     9841 gtcttcctaa agttccggct gctgagagaa tcgacgtaga cgagacaggt aagatcacag
     9901 gtctgttcta atccggttga aatcaatcga ataattcaaa aatataaaaa tcatatttat
     9961 atatgatatg tgtccagacg attttacagg cgggaagatt ttcccgcctg tttttttctt
    10021 tattttttta taagataatc ttttccggaa ataccaggtt ccgtcatatg gatcggatcc
    10081 agaatgcgat taagttcatc ctcgtccata agcttttctt tcagaatcag acttcttaca
    10141 gattcgcctg tcttaattgc cttttttgca atatccgcag ccttctgata tccaagatgg
    10201 gggctgattg cagtgataat acctacactg ttttctacca gataacggca tctttcttca
    10261 tttgccgtaa ttcctacaat acaattatct accaatgtct ggactgcata gccaagagta
    10321 tcgatagact gaaacatgca atagaaaata atcggctcaa acgcatttaa ttccagctga
    10381 ccagcctctg cagccatggt aatggtaaca tcattaccaa taatattaaa agcaacctga
    10441 ttcactactt caggaataac cggattaact ttacctggca taatagagga accattctgt
    10501 tttgccggaa gattaatctc cccaaaacca gtacgtggac cggaggacat cagacggaga
    10561 tcatttgaca ttttggaaag agttaccgca catgctttca cagcaccgga aacagctaca
    10621 aatggatcca gattctgagt ggaatcaatc agatcaaaag cctgtataaa gtccattccc
    10681 gatatttcag tgagatttgg aacaattctt ctcagatagc cctcatctgc attaattcct
    10741 gttccaatag cagtacctcc catattaaga gtccgcattt catccattgc tttatccatt
    10801 ctgtggatat cacgcatgat tgctaccgaa tatgccttaa attcctgtcc cagacgaatt
    10861 ggtactgcat cctgcatctg tgtacgcccc atttttatta tgtgatcaaa ctctgtagct
    10921 ttttcattaa gagcatcata gaggcgaaga agctgttttt tcagattctg caacaaacga
    10981 agagaagtca ttttaccggc agtaggaatc acgtcattgg tagactgtcc acaattcaca
    11041 tcatcgttag gatttataat tgtataatcg cccttttttc ctcccagtat ctcaatcgcg
    11101 cgatttgcaa ttacttcatt ggcattcata tttaaagatg tgccagctcc tccctgaaca
    11161 ggatccacaa taaattcatt atggaatttt cctgaaacaa tttcatcaca tgcctggaca
    11221 atcgcctgtg cttttttctt ctcaagaagc cccacctcac aattggttat cgctgctgct
    11281 ttttttatgt atgcaagact gttaataatt tccggatgca tattcagccc cgtaatgtgg
    11341 aaattttcag ccgcacgtaa ggattgtact ccataatata catcttccgg aatatccttt
    11401 acaccaatag aatccctttc tacacgatag tctgtttttt tcatagttat tcgccctccc
    11461 atgtatttgc cctcattata tatctctgct ataatataat caaatacata tatttttata
    11521 aaatatatag tgtttaaatt atatatcgga ggagtttata tgtttcaggg aatggaatac
    11581 atctatgagg tatacaagga aaaaagcttt tccaaagctg ctgctgctct tttcatttcg
    11641 cagccttctt taagcgccaa tgtaaaacgt gtggaaaacc gtattggcta tcctattttt
    11701 gatcgaagta ccaaaccttt acagttaact gaagtcggaa aacattatat acaggctgtt
    11761 gaaaaagtca tggatattga aaataatctc gaaaactacc tactggatct gggaaatctc
    11821 aaaacaggaa ctcttaatgt aggtggcagt aacttttttt cttcgtggat tctgcctccc
    11881 cttattgctg atttttccca aaaattcccc catgttcaaa tttctcttgt agaagaaagt
    11941 acagcaaagc tatcccagtt tctccaggcc ggaaagttag atctggtgat tgataactgt
    12001 attctggata accagatttt tgaacgttat atctaccaga aagaacaact tcttcttgca
    12061 gttcccaaaa attattcagt aaataccaga ctgcagaaat atcagattcc tattgaggaa
    12121 atccggaacg ggcagttccg ttcttctcat attccttctg ttccattaaa caaattcgag
    12181 aacgaaccat ttattattct tcgttcagat aatgataccg gtaagcgtgc acttaccatt
    12241 tgtcaggaaa atcacttttc gccttctgta gtatttcgcc tggatcagca gatgactgcc
    12301 tataatattg catgtttggg aatgggtatc actttcatcg gggatcttct gctctccaga
    12361 gttccaacaa attcagaact tgttttttat aagctgcccg gtcagagcag taaacgcact
    12421 gtgttttttt actggaagaa aggccgctat atcagcagag ccatggaaga attcctgaag
    12481 ctgccctttt cctgatatgt cataatcaaa taggctatgg tgattggtca tcatcagatg
    12541 tacgtcaaaa tggggttgtt gtgctaaata agcacaacaa ccccagtatg tcaggcagat
    12601 attcgattag aacagtggct tcatagccgg atacagagtt ctgaacttct gatatctctc
    12661 ttcatatttt gcaaccagtt caggatccgg ttctactgta tcaacaactt tggcaaattt
    12721 cttaccgatg gtttctacat ccgggtaagc accacagcct actgctgcca gcatagctcc
    12781 acccatggac ggtccttctt cgttctccag aacatcaacc ttcaggttca taacgtttgc
    12841 aatgatcttc ttccacagtg ggctcttagc tccgccaccg cagatcttgg ttctctcaat
    12901 cttgattcca aggtttcttg caacttccag ggaatcacga agaccaaagg caacaccttc
    12961 cagaacagcc tgtgtcatgt ctgctcttgt gctgtccatg gacattccga agaatacacc
    13021 tcttgcatca ggattattat gaggtgaacg ttctcccatc aaatatggaa ggaagaatac
    13081 atgattctct cccagcttct gaattggagc ctgctctgct gcgaaatcct ttgtctgaag
    13141 aatctcctct gcccaccatt tgttacagga agctgcgctg agcatgcatc ccatcagatg
    13201 atagcttcca tctgcatgac agaaagaatg aagtgcgtta ttttcgtcca caccaaagtt
    13261 tttactggaa ataaacacag ttccggatgt tccaagagaa atattacact gaccgtcacc
    13321 aactgtacct gttcctacag cagctgccgc attgtcacct gcacctgcaa caacttttac
    13381 attctcactg aatccaagtt ctttcgcaat ctcaggtttc agagttccta ctacttccca
    13441 actctcatac agtttcggaa gctgctcttc tgtgattcca cagatctcca gcatttcttt
    13501 tgaccagcag cggttcttca catcaagaag aagcataccg gaagcatcag aaacatctgt
    13561 acaaaaagaa ccggacagac gatatgccag ataatcctta ggaagcataa tctttactac
    13621 cttcttaaag ttctcaggct catttttctg catccagagg atcttcggtg ctgtgaagcc
    13681 tgcgaaagca atatttgctg tatactgtga aagtttgtct tttccgatca ctgtattcag
    13741 atattctgtc tcttcgcctg tacgtccgtc attccagagg attgcaggac ggatcacatt
    13801 atcatccttg tcaagtgtta ccagaccatg catctggccg ccaaaaccaa ttcctgctac
    13861 ctgcgctctg tcgatatcct ttgtcagctc tttcatacct tccatactct gtgcaaacca
    13921 gtcttccggt ttctgctcag accagcccgg atgtgggaag aataaaggat attctctgga
    13981 tacgatgtta cagatttttc ctgattcttc cataagaaga agttttacag cggaagtacc
    14041 aagatcaata ccgatataat acataagtgc gctccttttc tatttctaat ctaatacatc
    14101 ccagagcaaa gccccgggat gcctttaata tagtgtcagt ttatttattc tgtattcaga
    14161 ttcattcact tcacatgaac attaataacc cgttttactg atttctcatt aaccccatgg
    14221 attctctgtc ggatatctta cacctgccgg ctggttgtat ccaatcttct taacatccag
    14281 tccaaggaat ttcactacct catagaatgc ttttccgtaa tgtccaaaca taactgctcc
    14341 atgatgcgga tagttgccct cgatcagtac gtgacggtag aatcttccca tttctttgat
    14401 tgcgaaaata ccgataccac cgaatgatct tgtaggtaca tccagtactt caccttctgc
    14461 aacataagaa accagctcgc cctcggaatt gcactgtaaa cgatagaatg taatgtcaga
    14521 tgcagcaata tcaccttcaa gagttcctct tgtaaagtct ggttcagatc ctgccggctc
    14581 aagaagtctg tgctggatca gctgatattt aacagctctg gaatcacaca tcttgcatgc
    14641 aggagtattt ccacaatgga atcccataaa tgtatcagta agcttataat cgtattttcc
    14701 tttaatatct tcatcataga tatactgtgg aacagagttg ttgatatcaa gcagtgtaac
    14761 tgcatcattg gaaatgcaaa gtccgatgta ctcgctgagt gctccgtaga tatcaacctc
    14821 acaggatacc ggaattcctc tggaaaccag acggctattt acatagcaag gttcaaatcc
    14881 aaactgtgac gggaatgcag gccaacattt gtcagcaaat gcaacgtatt ttcttgctcc
    14941 cttatgagcc tctgcccagt caagaagtgt aagctcaaac tgtgccattt tcacattaag
    15001 gtcagcataa tatttgcctt cgcccatctc ttttgccata tctgcacaaa cttccgggat
    15061 acgaggatca ttttcatgct ctttgaaaga aacaagaaga tcaagctctg agttctcttc
    15121 aatctcaaca cccagctcat agaggccttt aataggtgcg ttgcatgcga agaagtcctg
    15181 tggacgtggt ccgaaagtaa tgatcttaag attgctgaca ccgatgactg cacgtgcaac
    15241 cggtacgaaa tcagcgatca tctttgcaat atcatctgct gttccaacag gatattccgg
    15301 aatatatgct ttcagatgac gcatttttaa gttgtaggag cagttaagca taccacagta
    15361 agcatcacct ctgccgttga tcatatcacc gtcaccttct gctgctgcta catacataca
    15421 aggtccgtca aatctctctg cgatcagagt ttcaggagtt tcaggtccga agtttcc
//
