LOCUS       gnlProkkaPLNCFLGH_3    11573 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PLNCFLGH_3.
ACCESSION   gnlProkkaPLNCFLGH_3
VERSION     gnlProkkaPLNCFLGH_3
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 18:14:31
            Original ID  :: gnl|Prokka|PLNCFLGH_3
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 25526
            Orig. end    :: 37099
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11573
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11452]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11452
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..11573
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11573
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(266..553)
                     /locus_tag="ctg3_29"
                     /transl_table=11
                     /translation="MKLEFRQTVTCNHLTLARVCKTIDWQQPLPRCGEYVTGLDTLDGE
                     QELPVRKLLHRAQDGSCLAELPGFNIAQLRFSYRELELLAAQKGWTLQKL"
     CDS             692..916
                     /locus_tag="ctg3_30"
                     /transl_table=11
                     /translation="MYQRIRDLREDRDLLQKDVAAYLKCTQVCYSNYETGKRDIPTEVL
                     IQLAHLYHTSTDYILGLTDNSAPPVPRKA"
     CDS             967..1203
                     /locus_tag="ctg3_31"
                     /transl_table=11
                     /translation="MPPTGVEPVLCLQKGILSPSCLPISPQRRNPGLQSPAALWLEREP
                     GITGVRKNYYNHTAIRNLVVLTFLLKSAAFMIQ"
     CDS             complement(1245..2762)
                     /locus_tag="ctg3_32"
                     /transl_table=11
                     /translation="MNEIKVEPYIPDEDYDNPAMVVDFYEFTMANCLFLHGFKDTTLVF
                     DMFFRKNPDNQGYSISAGQRKLTRFLLDYHFNEQDIHWLRTKGMSEEFCEYLRTYKWKG
                     DMYALPEGTVCYPHVQMVRIECDLVGAILIETYLLQTMNFHSLIATKATRVTGLNTHTP
                     RSVMEFGTRRAQGESAGNDGAYAAVLGGCIGTANCLAEMKFGAEVKAVGTVAHSFIEFF
                     PTEFDAFKAFADTYPDSVSLLLDTYNIMESGLPNLIKLDDYLIEKYPNDPNRRVKSARI
                     DSGDLARGSKRLRKALDAAGKPYIKLVASNGLDEKKIANMELYEHAHFDSYGVGENLIT
                     SASDPVFGGVYKLVAVKKPDGSYTPKMKCSDSASKAIIPGKKMPWRLYDENGQAQCDLI
                     AMDGEVIEAGKPVTMVNLDSDAIERTITFIPTAVRPLLVPHILGGELAIDLPSIAEKKA
                     YIAKQLTEETWESELRLECPHKHYVNMTPAVAECRSRMYAELHGGKV"
     CDS             complement(2985..4499)
                     /locus_tag="ctg3_33"
                     /transl_table=11
                     /translation="MAYFYEEPSRTFGEYLLVPGYSSAENVPTAVSLKTPLVKYRKGQE
                     ECPLQMNIPMISAIMQSVSGDKLAIALARQGGVSFIYGSQSIENEAAMVRRVKSFKAGY
                     VVSDSNLAPTATLHDVLELKARTGHSTIAITADGTPGGKLLGIVASRDYRINHTPDDAC
                     VTTFMTPVEKLVTAPANTSLHDCNNIIWDNKINTLPLVDAEGNLVYMVFRKDYDSHKAN
                     VNELLDKNKSYVVGAGINTRDYAQRVPALVEAGVDVLCIDSSEGYSEWQSRTIGWIREH
                     YGDTVKVGAGNVVDAEGFRFLAEAGADFVKIGIGGGSICITRETKGIGRGQATAVIEVA
                     KARDEYYKETGIYVPICSDGGIVHDYHITLALAMGADFVMLGRYFARFDESPTNKVRIN
                     GQYMKEYWGEGSNRARNWQRYDLGGSTKLSFEEGVDSYVPYAGPLADGVQTTLYKVKST
                     MCNCGALSIPELQQKAKLTVVSSTSIVEGGSHDVVLKNATPSIMNG"
     CDS             5071..5916
                     /locus_tag="ctg3_34"
                     /transl_table=11
                     /translation="MNMLPQAEKRSLGYGMKTKLGIVGCGFLGNIVADAWKKGLLPDYE
                     LVGVTSRTRASAEKTAANVGCAVCEDVDALLALEPEYIVEAASVESVRAMAIPVLKRGV
                     NLVILSIGAFADLDFYAQVKAAAVEGGAKVHLASGAIGGFDVLQTVTLMAQAQGLPETA
                     GIETHTGAKGFRNTPVWAEHLLTDTEKTTVFTGNAKQAIATFPRRVNVAVATSLATTGP
                     EITGVTMHSVPGWVGDDHCITAEIEGVKAVVDICSSTSAIAGWSAVSLLRNLASPVCFY
                     "
     CDS             5935..6831
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 95.9; E-value: 3.1e-29)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_35"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 3e-17, bitscore:
                     53.8, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEKLVAIEPVSLIPSAEEELHRYAKEVVLYRDVPGSDAEMVRRI
                     GDADAVLLSYTSRMGKEVIAQCPNIRYIGMCCSLYSEESANVDIAYARTRGIKVLGIRD
                     YGDRGVVEYVLHELTGLLHGFGMPMLRDEPVEITGLKVGIVGLGVSGRMIADALQFMGA
                     EISYFARSAKPDAEAAGMTFKPLPQLLADSEVVFTCLNKNVLLLGENEFAQLGAGKVLF
                     NTSIGPGFDSAALEKWLDLPGTRFFCDTRAAAGPVAEDFFSRENVRCANVSAGRTKQAF
                     VLLSKKVLDNIRTALGE"
     CDS             7054..7854
                     /locus_tag="ctg3_36"
                     /transl_table=11
                     /translation="MKTALTIAGSDSSGGAGIQADIKTMTANGVFAMSAITALTAQNTT
                     GVTAIFDTTPQFLAQQIDAVFTDIYPDAVKIGMVSSAPLIDTIAERLRFYGAKHIVVDP
                     VMVATSGAKLLQDDAVQALTEKLLPLAEVLTPNIPEAEILSGMTITNAADMEAAARTIS
                     ERYGCAVLCKGGHQINDADDLLWRGGTGKWFKGKRIANPNTHGTGCTLSSAIASNLAKG
                     YDLDTAVERAKAYISGCLSAMLDLGHGSGPMDHTFNLKGDFVRD"
     CDS             7847..8524
                     /locus_tag="ctg3_37"
                     /transl_table=11
                     /translation="MTDLPFVSALVQADLPVWEQCLQTEFLQKMENGTLSEDCFKSYLV
                     EDSLYLREYAKIFAWGMTKATTMAAMRTYYSLLSFVQENEDLTRLRYLEQYGLREADIQ
                     SLPLRPESRAYLDCMIDAARTGEGEAECLMACLPCMLSYGWLFQKLLQRSPAVKDTYYG
                     ALVLDYAGPGYDAACRAWAERAEAACTGLSPERAARCRAIFRACSEHELHFWEMCATPR
                     TDI"
     CDS             complement(8586..10004)
                     /locus_tag="ctg3_38"
                     /transl_table=11
                     /translation="MSMTTPIVDFVRSYAKSGTARLHMPGHKGQSLLGFEPLDITEICG
                     ADELYAPEGIIAESEANATRLFGTAHSYYSTEGSSQCIRAMLFLALQGAPQNGKRPVLL
                     AARNAHKALLYAAALLDFDIRWLWPSAQAEGALCSCPVTAEALTGALHAMAQQGNTPFG
                     VYVTSPDYLGGVQELPALAAVCRAQDVPLLVDNAHGAYLRFLPQNCHPIAQGAAMCCDS
                     AHKTLPVVTGGAYLHLAHDAPVQDEAAVRGALALFGSTSPSYLILQSLDACNAVLAGDY
                     PRRLVQCCAALEGLRRSLNKAAAARQCPVPLAVAGAQQEPMKLTLDAAALGCTGTALAD
                     ALRRAQLECEYADPRYVVLMFTPENPPQDFERLQTALEQLLAAVPAGLSRPENRAGEFA
                     ALQQQAVQRCTIRQAVLGAQVRVPVHKALGRVCAMPTVSCPPAIPVAVSGEEITPAAIA
                     LMQRYGIKELSVLR"
     CDS             complement(10001..11452)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_39"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.3e-30,
                     bitscore: 97.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.9e-15, bitscore: 48.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.1e-16, bitscore: 51.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.5e-20, bitscore:
                     63.6, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHQYQLNGYNIVLDTCSGSVHVVDEVAYDVIAMYPEHTADEIVA
                     AMLAKYGSRPDVTEEDLRQCIDDVTSLKENGKLWSPDVYKDMAFDFKNRNTVVKALCLH
                     VAHSCNLSCSYCFASQGRYHGDRALMSFEVGKRAMDFLIENSGTRRNLEVDFFGGEPLM
                     NFEMVKKLVAYCREQEKIYNKNFRFTMTTNGVLIDDDVIDFCNKECHNVVLSLDGRKEV
                     NDRFRVDCAGNGSYDRIVPKFQEFVKKRGDKNYYMRGTYTHFNTDFTNDIFHMADLGFT
                     ELSMEPVVCDPSDPSALTEADLPILKEQYEILAKEMIKRDREGRGFTFYHYMIDLTGGP
                     CIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDPKYLLGDIWKGVTNTAVRDEFKHCNA
                     YARKECQDCWAKLYCSGGCAANSYHATGSITGVYEYGCELFKKRMECAIMIKVAENQEL
                     AAKGIEVPIELGSTCNACADGEACE"
ORIGIN
        1 aacttcgacg tggatctcgg gcttggtgga acgagtcttg atcacgttgc cgcatgcgca
       61 ggtgatggtg cagtcaacgt agttcggatg gataccctgt ttcattcttt tcacctcaat
      121 tctggttctg acgtattggg gccatattta atgtatgtgc ccatcacaac cttcaatatc
      181 ggctaccccg tcgagcggcc ttggaaacga ttgccttact attatagcac gaattggcca
      241 gaatgcaaga gggaaattta agtttttaca gcttttgcag cgtccagccc ttttgtgctg
      301 ccaacagctc cagctcccgg taagaaaacc gcagctgcgc gatgttaaag cccggcagct
      361 ccgcaaggca gctgccgtcc tgtgcccggt gcagcagctt gcgcaccggc agttcctgct
      421 cgccgtccag cgtatccagc ccggtcacat attctccgca ccggggcagc ggctgctgcc
      481 agtcgatcgt tttgcagacc cttgcaagtg taagatggtt gcaggtcacc gtctgccgga
      541 attccagttt catgatgctc tccccttttg cgccggagat tcacagctgt tcccggcgcg
      601 atactatgat ataacatttt gttttatatg tcaatataac atttcgttat gcctatactt
      661 taccttaaat aaagcctttg aggtaaacac catgtatcaa cgtatccggg atctgcggga
      721 ggatcgtgat ctgctgcaaa aggatgttgc ggcgtatctg aaatgcacac aggtctgcta
      781 ctccaattac gagaccggca agcgggatat ccccaccgag gtgctgatcc agcttgctca
      841 cctttaccat accagtaccg attatatcct tggtctgacg gacaacagcg ccccgcccgt
      901 tccccgcaaa gcataaaaga aaaagcccag aatcattcgg atcaacgaac gattctgggc
      961 tttcacatgc cgccgacggg ggtcgaaccc gtactctgtc tccagaaagg gattttaagt
     1021 ccctcgtgtc tgccaatttc accacagcgg cgcaaccccg gcttacaaag ccctgctgcc
     1081 ctctggcttg agagggagcc gggaataaca ggtgtgagga aaaattatta caaccacact
     1141 gctattcgca atctggtggt attaacattt ttattaaaat cagcggcttt tatgatacaa
     1201 tagtttccct gttttgtcaa gaaaaaccgc ttattcggtg ccgcttacac cttgcctccg
     1261 tgcagctcgg cgtacatccg ggagcggcac tcggccactg cgggggtcat gttgacgtag
     1321 tgtttgtggg ggcactccag acgcagctcg ctctcccaag tctcctcggt gagctgcttt
     1381 gcaatatagg ccttcttttc tgcaatagag ggcaggtcaa tggccagctc gccgcccaga
     1441 atatgcggca ccaacagcgg gcgcacagcg gtggggataa aggtgatggt gcgctcgatg
     1501 gcgtccgaat ccagattgac catggtgacc ggcttaccgg cctcgatgac ctcgccgtcc
     1561 atggcgatca ggtcgcactg tgcctgaccg ttttcatcgt acaggcgcca cggcatcttc
     1621 ttgcccggga tgatggcctt gctggcagaa tcggagcatt tcatcttggg ggtgtagctg
     1681 ccgtccggct tcttcactgc caccaacttg tacacgccgc cgaacacggg gtcggaggcg
     1741 gaggtgatga ggttttcgcc cacgccgtag gagtcgaagt gtgcgtgctc gtacagctcc
     1801 atgttggcga ttttcttctc atccagaccg ttggaggcca ccagcttgat gtagggctta
     1861 ccggcggcat ccagtgcctt gcgcagccgc ttggagccgc gggcaaggtc gccggagtcg
     1921 atgcgggcgc tcttgacacg gcggttggga tcgttggggt atttctcaat gagataatcg
     1981 tccagcttga tcaggttggg caggccgctt tccataatat tataggtatc cagcagcagg
     2041 ctgaccgaat ccgggtaggt atcggcaaag gccttgaagg catcgaattc ggtggggaag
     2101 aactcgataa agctgtgtgc cacggtgccc acggccttga cctctgcacc gaacttcatc
     2161 tctgccagac agttggccgt gccgatgcag ccgcccagca ctgctgcgta agcgccatcg
     2221 ttaccggcgc tctcgccctg tgcgcggcgg gtgccgaact ccatgacgct gcggggggtg
     2281 tgggtgttca gaccggtaac gcgggttgcc ttggtggcga tcaggctatg gaagttcatg
     2341 gtctgcagca ggtaggtctc gatcaggatc gcgcccacca gatcgcactc gatgcgcacc
     2401 atctgcacat gggggtagca gaccgtgccc tcgggcaggg cgtacatatc acccttccac
     2461 ttgtaggtgc gcagatactc gcagaattcc tcgctcatgc ccttggtgcg cagccagtgg
     2521 atgtcctgct cattgaagtg atagtccagc aaaaagcggg tcagcttgcg ctggcctgcg
     2581 ctgatggaat agccctgatt gtccgggttc ttgcggaaga acatatcaaa caccagcgtg
     2641 gtatccttaa aaccatgcag gaacaggcag tttgccatgg tgaattcgta aaagtccacc
     2701 accatcgcgg ggttatcgta gtcctcgtca gggatataag gctcgacctt gatctcgttc
     2761 atgaacgttt tcctctctat ttatgcccgg cgcgggggtc ttccccgctg cgccgcctgc
     2821 cgcttgcccg gcagggggat tctctgccct gtcaagacaa agcgtttcta ccatgatagc
     2881 acgatttccc tgcctgtgca agtatttttg tgcaaaaaga gaccgctgca caaacgctgt
     2941 gcagcggtct ctttgttcaa agtaatcgct tgctcagaac aggcttagcc gttcatgatg
     3001 ctaggggtgg cgttcttcag cacaacgtcg tggctgccgc cctccacgat ggaggtagag
     3061 gaaacaacgg tcagcttggc cttctgctgc agctcgggga tggacagagc gccgcagttg
     3121 cacatggtgc tcttcacctt gtacagggtg gtctgcacgc cgtccgccag aggaccggcg
     3181 taaggcacat agctgtccac gccctcctca aagctcagct tggtggagcc gcccagatcg
     3241 tagcgctgcc agttgcgggc acggttggag ccttcgcccc agtactcctt catatactgg
     3301 ccattgatgc gcaccttgtt cgtggggctc tcgtcaaagc gggcaaagta acggcccagc
     3361 atcacaaagt ctgcgcccat agccagcgcg agggtgatgt ggtagtcgtg gacgatgccg
     3421 ccgtcggagc agataggcac atagatgccg gtctccttgt agtactcgtc acgagccttg
     3481 gcaacctcga tgacagcagt agcctgacca cggccgatgc ccttggtctc acgggtgatg
     3541 cagatggagc cgccgccgat gccgatcttc acaaagtctg caccagcctc agcgaggaag
     3601 cggaagccct cggcgtccac cacgttgccg gcacccacct tgacggtatc gccgtagtgc
     3661 tcgcggatcc agccgatggt gcggctctgc cactcggagt agccctcgga ggagtcgatg
     3721 cacagcacat ccacaccggc ctctaccagt gcgggcacgc gctgggcgta gtcgcgggta
     3781 ttgataccgg cacccacaac atagctcttg ttcttgtcca gcagctcgtt gacgtttgcc
     3841 ttgtgggaat cgtagtcctt gcggaatacc atatacacca gattgccctc ggcatccacc
     3901 agcggcaggg tgttgatctt gttgtcccag atgatgttgt tgcagtcgtg cagagaggtg
     3961 ttggccggag cggtgaccag cttttcaacg ggagtcataa aagtggtaac gcaggcatcg
     4021 tccggggtgt ggttgatgcg gtaatcgcgg gaggccacga tgcccagcag cttgccgccc
     4081 ggagtgccgt cggcagtgat ggcgatggtg gagtgaccgg tgcgcgcttt cagttccagc
     4141 acatcatgca gggtggcggt gggagccaga ttggaatcgg acaccacata accggccttg
     4201 aagctcttga cgcggcgcac catggcagcc tcgttctcga tgctctgaga gccatagata
     4261 aaggaaacgc cgccctgacg agccagtgca atggccagct tatcgccgga gaccgactgc
     4321 atgatggcgc tgatcatggg gatattcatc tgcagcgggc actcctcctg tcccttgcgg
     4381 tacttgacca gcggggtctt caggctgacc gccgtgggca cattctccgc agaggaatag
     4441 ccggggacca gcaggtactc gccaaaggtg cgggaaggtt cttcgtagaa ataagccata
     4501 atcaaactcc ttttctctta acgcatccga tacaaatcag catcaaaatc attcatgttt
     4561 gctgcctata aattgattgt atatacttta ccacaaagcc cgcaagaata caaacccctg
     4621 ccgcgccaaa ctttataatt gtcctttgcg gaaaaacaga caaattgcca agcgttttca
     4681 ggcattggtc atactttgat ttttgaagta tcacttttgc aggcaaaaca gggcttgcag
     4741 aacgcaaaaa agctcgtcca gaataccgga cgagcccttt tgcacacgaa gcgggacact
     4801 gcctgtgcgg cgcatggatc atagctgtga aggagaacag ccggaggagg aggatccgcg
     4861 cccagtatcc caaaaacaag aagaaaaaga tttcacacac agccttgggg ctttgccctt
     4921 gctgtaacca tattgtaact cttttgaaac cattttgcaa tagggttttg taattttttt
     4981 gtaatttatt ttgttaactt tttatgtcct gccccgccgg gctgctgcaa acatcatttt
     5041 cctttttgta cccgatatgg tatactggtt atgaatatgc tgccacaggc agaaaaaagg
     5101 agtttaggat acggtatgaa aacaaaattg ggtattgtgg gctgcggttt tctgggcaac
     5161 atcgtggctg acgcgtggaa gaagggtctg ctgccggact acgagctggt gggcgtgacc
     5221 agccgcaccc gcgcttcggc tgaaaagacc gccgccaacg tcggctgcgc cgtctgtgag
     5281 gacgtggacg cgctgctggc acttgagccg gagtacatcg tggaggctgc ctcggtggag
     5341 tcggtgcgcg ccatggccat ccccgtgctg aagcggggcg tgaatctggt cattctatcc
     5401 atcggtgcct ttgcggatct ggatttctac gcacaggtca aggcagccgc cgtggagggc
     5461 ggtgccaagg tgcatctggc cagcggtgcc atcggcggct ttgacgtgct gcagaccgtc
     5521 accctgatgg cacaggcaca gggtctgccg gagactgccg gcatcgagac ccataccggt
     5581 gcaaaaggct tccgcaatac gccggtgtgg gcagagcatc tgctgaccga caccgaaaag
     5641 accaccgtgt tcaccggcaa cgccaagcag gccattgcta ccttcccccg ccgggtaaac
     5701 gtggcggtgg ctacctctct ggccaccacc ggtcccgaga tcaccggtgt gaccatgcac
     5761 tccgtgcccg gctgggtggg cgacgaccac tgcatcaccg ccgagatcga gggcgtgaag
     5821 gctgtggtgg atatctgctc ttccaccagc gccattgcgg gctggagcgc cgtctccctg
     5881 ctgcgcaatc tggcctcgcc cgtttgcttc tattaatata aggaggagtc tgccatgttt
     5941 gaaaagcttg ttgccattga gcctgtcagc ctgatcccct ctgccgagga agagctgcac
     6001 cgctatgcca aagaggtggt gctgtaccgg gacgtgcccg gcagtgacgc cgaaatggtg
     6061 cgccgtatcg gagacgccga tgccgtgctg ctgagttata cctcccgcat gggcaaggaa
     6121 gtcattgcgc agtgccccaa catccgctat atcggcatgt gctgcagcct gtactctgag
     6181 gagagtgcca atgtggatat cgcctacgca cgcacccggg gcatcaaggt gttgggtatc
     6241 cgggactacg gcgaccgcgg cgttgtggag tacgttctgc acgagctgac cggcctgctg
     6301 cacggctttg ggatgcccat gctgcgggac gagccggtgg agatcaccgg tctgaaggtt
     6361 ggcattgtgg gtctaggcgt ttctggccgg atgatcgccg atgcgctgca atttatgggc
     6421 gcagagatca gctactttgc ccgcagcgca aagccggacg ccgaggctgc cggtatgacc
     6481 ttcaagcccc tgccccagct gctggcggac agcgaggtag tgttcacctg cctgaacaag
     6541 aacgtgctgc tgttgggcga aaatgagttt gcccagctgg gcgcaggcaa ggtgctgttc
     6601 aacacttcca tcggccccgg ctttgactcc gctgcactgg aaaagtggct tgacctgccc
     6661 ggcacccgct tcttctgcga cacccgcgcc gccgcaggcc ccgtggccga ggacttcttt
     6721 tcccgggaaa acgtgcgctg cgccaatgtg tcagcaggcc gcaccaagca ggcctttgtg
     6781 ctgctgagca aaaaggtgct ggacaacatc cgcaccgcac tgggcgaata agcggtgcat
     6841 tttgcgcagc ctgtttttct tgcatctttt ccccgattgt ggtatgcttt ctagtataaa
     6901 aagggagccc gtgcaagcgg gctgagagtg ggctgtattg ccctgacctg tgacctgatt
     6961 tggatcatgc caacgtaggg agatagcgct tttatctgcg gatatgtctt tgcgggcata
     7021 tccgcatttt tgctgcaaag gagcatttca cctatgaaaa ctgcattgac cattgccggc
     7081 agtgattcca gcggcggcgc cgggatccag gccgatatca agaccatgac cgccaacggc
     7141 gtgtttgcca tgagcgccat taccgccctg acggcacaga acaccaccgg tgtgaccgcc
     7201 atttttgaca ccacgccgca gtttctggca cagcagatcg acgccgtgtt taccgatatc
     7261 taccccgatg ctgtgaagat cggcatggta tcctctgccc cgctcatcga cactatcgcc
     7321 gagcggctgc gcttctacgg tgcaaagcac atcgtggtgg accctgtgat ggtggccacc
     7381 tccggcgcaa agctgctgca ggacgatgct gtacaggcgc tgaccgaaaa gctgctgccg
     7441 ctggctgagg tgcttacccc caacatcccg gaggccgaga tcttgtccgg catgaccatt
     7501 acaaacgccg ccgacatgga agccgctgcc cgcaccatca gcgagcgtta cggctgcgcc
     7561 gtgctgtgca agggcggcca ccagatcaac gatgccgacg accttttgtg gcgcggcggc
     7621 accggcaagt ggttcaaggg caagcgcatt gcaaacccca acacccacgg caccggctgc
     7681 accctgtcca gcgccatcgc ttccaatctg gccaaggggt acgacctcga caccgccgtg
     7741 gagcgtgcca aggcctacat ttccggctgt ctgtctgcca tgctggattt agggcatggc
     7801 tccgggccca tggatcacac cttcaacctg aagggagatt ttgtccgtga ctgacctgcc
     7861 cttcgtttcg gcgctggtgc aggcagacct gcctgtgtgg gagcagtgct tacagaccga
     7921 gtttctgcaa aagatggaaa acggcaccct gagcgaggac tgctttaaaa gctaccttgt
     7981 ggaggacagc ctgtatctgc gggagtacgc caaaattttt gcgtggggca tgaccaaggc
     8041 caccaccatg gcggccatgc gcacctacta ttccctgctg tcctttgtgc aggagaacga
     8101 ggacctgacc cggctgcggt atctggagca gtacggtctg cgggaagctg atatccagtc
     8161 cctgcccctg cgcccggaaa gccgcgccta tctggactgc atgatcgacg ctgcgcgcac
     8221 cggcgagggc gaggccgagt gcctgatggc ctgcctgccc tgtatgctga gctacgggtg
     8281 gctattccag aagcttttgc agcgctcccc cgccgtaaag gacacctact acggcgcgct
     8341 ggtgctggac tacgccggtc ccggctacga tgccgcctgc cgcgcatggg cagaacgcgc
     8401 tgaagcagcc tgcaccggcc tttcgccgga gcgtgccgcc cgttgccgcg cgatcttccg
     8461 cgcctgctcg gagcacgagc tgcacttctg ggagatgtgc gccacgcccc ggacggatat
     8521 ttaagaataa atatagagaa cccggaaggt ccgcagacct tccgggttct cttcttataa
     8581 aatctttatc gcagcaccga gagttctttg atgccgtagc gctgcatcag ggcgatggct
     8641 gccggggtga tctcctcgcc gctgaccgcc acagggatgg cgggcgggca ggacaccgta
     8701 ggcatggcac acacccgtcc cagtgccttg tgcaccggga cgcgcacctg tgcacccagc
     8761 accgcctgcc ggatggtaca gcgctgcacc gcctgctgct gcaaggcggc aaactctcct
     8821 gcccggttct cggggcggga cagtccggca ggcacagcag ccagaagctg ttccagcgcc
     8881 gtttgcaggc gttcaaagtc ctgcggcggg ttttccgggg tgaacatcag caccacatag
     8941 cgggggtcgg catactcgca ctccagctgt gcgcggcgca aagcatctgc cagcgctgtg
     9001 ccggtgcagc caagggcggc ggcgtccagc gtaagcttca tcggctcctg ctgtgccccg
     9061 gcaactgcca gcggcaccgg gcactgccgc gccgctgcgg ccttattcag gctgcggcgc
     9121 agaccttcca gcgccgcgca gcactgcacc agccgccggg ggtagtcccc tgccagcacc
     9181 gcattgcagg catccagcga ctgcaaaatg aggtaagagg ggctggtaga gccgaacagc
     9241 gccagcgccc cccgcacagc cgcttcgtcc tgcacagggg catcgtgcgc cagatgcaga
     9301 tacgcaccgc cggtgaccac cggcagagtc ttgtgggcag agtcgcagca catggccgcg
     9361 ccctgtgcga tggggtggca gttctgcggc agaaagcgca ggtaggcccc gtgggcgtta
     9421 tccaccagca aaggcacgtc ctgcgcccgg cagacagcgg ccagcgccgg gagttcctgc
     9481 accccgccca gataatccgg gctggtgacg tacacgccaa agggggtgtt gccctgctgt
     9541 gccatcgcgt gcaaagcccc tgtcagcgct tcggctgtga cggggcagct gcacagtgca
     9601 ccctctgcct gcgcagacgg ccagagccag cggatatcaa aatccagcag cgccgccgca
     9661 tacagcagcg ccttgtgggc gttgcgggcg gccagcagca ccgggcgctt accgttttgc
     9721 ggtgcgcctt gcagcgccag aaacagcatg gcacggatgc actgagacga cccctcggtg
     9781 ctgtaatagc tgtgcgccgt gccgaacagc cgggtggcgt tggcttcact ctcggcaata
     9841 atgccctccg gcgcgtaaag ctcgtccgca ccgcagatct cggtgatatc cagcggctca
     9901 aagcctaaaa ggctctgccc cttgtggccg ggcatatgca gccgggcggt accggacttt
     9961 gcatagctgc gcacaaaatc cacgatgggg gtggtcatgc tcattcgcag gcttcgccgt
    10021 cagcgcaggc gttgcaggta gagcccagct caataggcac ctcgatgccc ttggctgcca
    10081 gttcctgatt ctcggctacc ttgatcataa tggcgcactc catgcgcttt ttgaacagct
    10141 cgcagccgta ctcgtacacg ccggtaatgc tgccggtggc gtggtaggag ttggcagcgc
    10201 agccgccgga gcagtacaac tttgcccagc aatcctgaca ctccttgcgg gcgtaggcgt
    10261 tgcagtgctt gaactcatcc cgcacagcgg tgttggtaac gcccttccag atatcgccca
    10321 gcaggtactt ggggtcgccc acgaactggt ggcaggggta cagatcgccc cagggggtaa
    10381 cagccatgta ctcggtgccg gagccgcagc cggagatgcg cttatagatg caggggccgc
    10441 cggtcaggtc gatcatgtag tggtagaagg taaagcctct gccctcgcgg tcgcgcttga
    10501 tcatctcctt ggcaaggatc tcgtactgct ccttcaggat gggcaggtcg gcctcagtca
    10561 gggcgctggg gtcgctgggg tcgcagacca ccggctccat gctcagctcg gtaaagccga
    10621 ggtctgccat gtggaagata tcgttggtaa agtcggtgtt aaagtgggta taggtgccgc
    10681 gcatatagta gttcttgtcg ccgcgcttct tgacgaactc ctggaacttg ggcacgatgc
    10741 ggtcgtagct gccgttgcct gcacagtcca cgcggaagcg gtcgttgacc tccttgcggc
    10801 catccagact cagcaccaca ttgtggcact ccttgttgca gaagtcgata acgtcgtcat
    10861 caatgagcac accgttggtg gtcatggtaa agcggaagtt cttgttatag atcttctcct
    10921 gctcgcggca gtaggccacc agctttttga ccatctcaaa gttcatcagc ggctcaccgc
    10981 caaagaagtc cacttccaga ttgcggcggg tgccgctgtt ctcgatgagg aagtccatgg
    11041 cgcgcttgcc cacttcaaag ctcatcaggg cgcggtcgcc gtggtaacgt ccctgcgagg
    11101 caaagcagta agagcagctc aggttgcagc tatgggcaac gtgcaggcac agtgccttta
    11161 ccacagtgtt gcggttttta aagtcgaagg ccatgtcctt atagacatcc gggctccaca
    11221 gcttgccgtt ttccttcagg ctggtcacgt catcgatgca ctggcgcaga tcctcctcgg
    11281 tcacgtccgg gcggctgccg tattttgcca gcatggcggc aacgatctcg tctgcggtat
    11341 gctccgggta catggcgatg acatcgtagg ccacctcgtc cacaacgtgc accgagccgc
    11401 tgcaggtgtc cagcacgatg ttataaccgt tcaattgata ctgatgtacc attttacact
    11461 ccattccaga ttacacaaaa aaatgccgcc cggcaaaggc ggcatagggt ttgcaaaaat
    11521 tacttgttgc tgttctcgca ctgctggtta gccacgccgc aggaggtctt gca
//
