LOCUS       gnlProkkaHAPGPGAE_47   13715 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HAPGPGAE_47.
ACCESSION   gnlProkkaHAPGPGAE_47
VERSION     gnlProkkaHAPGPGAE_47
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 17:32:09
            Original ID  :: gnl|Prokka|HAPGPGAE_47
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13715
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13715
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4934:5192]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4935..5192
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13715
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13715
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             22..192
                     /locus_tag="ctg47_1"
                     /transl_table=11
                     /translation="MLRNLARNTQADWYDQMFYFVRAEMECYTNMLLLMQDIEEDKEWR
                     KEDFVEPDDNV"
     CDS             185..391
                     /locus_tag="ctg47_2"
                     /transl_table=11
                     /translation="MFKLETMIYASEDGTSSVFTLNPALQKQLAALATQHPEVCQRKAR
                     GEAGGVTYQVRDAALAIQPVRAS"
     CDS             complement(665..1828)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg47_3"
                     /sec_met_domain="NTP_transf_5 (E-value: 9.5e-48, bitscore:
                     153.1, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKTSELLIYLMACSLQEIKPEETLLANIDMEALLRLAKAHSVSA
                     MVCMALEQTDAFRCAEESIRLKWLDSKNKAIRKNMLLDAERHRLEKEFAEHGIWYMPLK
                     GSILKDWYPKFGMREMADNDILFDATRRQQVRDIFVNRGYSIESYNKSNHDAYEKQPIY
                     NFEMHVALFHEDRSTPQKKYENVVDRLVQDEKLPFRYHFTPEDFYVFVVAHAYKHYSHG
                     GTGIRTLADFYVMNRKLGKTLDWEYVESELRSLGILDYERDSRKLSQKLFGNTKTVLRS
                     ELTEEENQMFAYYLGATTYGNLFNQTLHRMQEFQPDGEPLTTKTKGKYIISRMFPNMEW
                     CKCYAPVVYKFPVLLPFYWVWRLIYKGITKRKKVTQEIKALKAVSRR"
     CDS             complement(1840..2784)
                     /locus_tag="ctg47_4"
                     /transl_table=11
                     /translation="MKSKALSIVVILLAVVLFGLLFVNHSQEQRQTAYMQQLQKEAMPY
                     EQEINDIRSKLAQKQRAINTKEDTSGILFGFVPASADDFTEIDKLAAEHSITPVILLDC
                     SQEKEQLTRILKKAVAKDYEIVLAGLQFDESILQTADEMKDLLVQMDDTKSPAFLLRNK
                     VNTEETRNLLNERGYTELILYDASLQAGMQENGKPYICYGFFKQPVYYADYISQVVTAH
                     TMMLASFDFSTIQNGTLQISDVERFMTLTDDRKAANELRYVDLNSAFQAVADQNATQQE
                     RQESYEKYEAEQEKRIQELKEKISAIYSRWDEY"
     CDS             complement(2781..4502)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 261.8; E-value:
                     2.2e-79)"
                     /gene_kind="transport"
                     /locus_tag="ctg47_5"
                     /transl_table=11
                     /translation="MKQKNTLQWLSIVAGKTKLLVGVLVAIQAVLSVSSIAFAFVLRRI
                     INMAVDGVQGGFWASLALLVGILLGQIMLSAASRFLNEYTSAAVENRFKHRLFSALLTG
                     DYASVAAVHSGEWMNRLTSDTTVVAGGVTQIVPGLVGMLVRLLGAVAAILWLEPRFLYI
                     LLPGGAAMMLLTYAFRKILKRLHKRIQETDGALRVFLQERLESLVIVRTFAKEEQMAQQ
                     ADALMDAHKAARMKRSNFSNLCNIGFAGAMDGAYLLGIGFCGYGILTGTMSYGNLIAII
                     QLVGQVQSPFANLTGYLPRYYSMLASAERLMEAEAFASDSTETVPEEQTLNFYQTELQS
                     LQLEHVCFTYQPPVQTEGEPPAMPVVLQDVSLTVRKGEYVVFTGPSGCGKSTLLKLLMC
                     LYPLDSGKRFLSTKTGNQPLTPAWKSLFAYVPQGNQLLSGSIRSIVAFGDEDRAQDENA
                     IYNALKIACADDFVRRLESGLDTVLGERGAGLSEGQMQRIAIARAVYSNHPILLLDEAT
                     SALDEATALRLLNNLRKMTDKTVILVTHRMNQAGFFDAELAFSKDGICVRERKTCK"
     CDS             complement(4499..4942)
                     /locus_tag="ctg47_6"
                     /transl_table=11
                     /translation="MRKSTFEEEITHNGFLLYRNVGDSMLPLIRQGKDLLLIARKPQGR
                     LNKYDVPLYRRDSGQYVLHRILKVRKNDYVLCGDNRWRREIGITDRHIIGVLTAVIRDG
                     QKLPVTDQRYRLYVHLWCDLFYLRAAVLWCRDLPGRIKRKLCQ"
     CDS             complement(4935..5192)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thurincin_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_7"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.4e-11,
                     bitscore: 34.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-14, bitscore: 44.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Thurincin_rSAM_RRE (E-value: 7.2e-09,
                     bitscore: 25.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLKDTFVTQEMDGEQVMVEADGGFAGMVRSNATAAFIIDQLKTE
                     TTKEAILDAMCKKYDAPRAVMAEDVDMVLANLKKIGALDA"
     CDS             complement(5274..5420)
                     /locus_tag="ctg47_8"
                     /transl_table=11
                     /translation="MEKYTKAQMEVIEFEAEDVITTSSIKICTSTDYDTITPDPSDKCI
                     WGD"
     CDS             complement(5488..6297)
                     /locus_tag="ctg47_9"
                     /transl_table=11
                     /translation="MMISNGYLFDGATVEQAVSHWKLKSVQITLDGTEEIYNRSKAFIY
                     KNGKSPYQVVLANIRRLLDAGVAVLIRLNMDEHNADNLMELADELHEQFGENKKLTVYS
                     HVLYEFLGCKEGIPADSRNKLYQKQQALYHKLVTLGYVKKLGLRKDLPLRRCIADHGGA
                     LTILPNGELGLCEQYSENNFIGHIDSEKLDESVRQSFRESWPALDACRKCFFYPECIRL
                     KKCIEQQKCYEQMQIKVREDTLSAMRNTYEAWLKKEQISEEEPHSDC"
     CDS             complement(6294..6842)
                     /locus_tag="ctg47_10"
                     /transl_table=11
                     /translation="MQTILPPSGNTIKILGKPKLAEHGLRWMTYVLAQPVEGGVLVFHT
                     LTRALLLLTQEEYTAPDVVAELRSSWFRVPQEMDDMKYADQVRFIRRTMQKEPEHTTTY
                     TIFTTTDCNARCFYCYEMGRSRIPMSNETAHKAAAYIAAHCGGEKVHLHWFGGEPLLIS
                     RSLTSSAPTLRKRALCTNP"
     CDS             complement(6854..7588)
                     /locus_tag="ctg47_11"
                     /transl_table=11
                     /translation="MHNTYRLAGHTVEIESVYPQVHTLCADYRTDDPPEYVITTTEADI
                     AYERQRSARADELEGAAVREHAEPYLETLAVYRKLAQLLVQDDILLMHGAVVAVDGQAY
                     LFTAKSGTGKTTHTRLWMQQFGDRAVMVNGDKPLLHITNEGVTVYGTPWDGKEHLSTNT
                     SCPLKALCILTRSETNHIERISKKEALSMLCQQVYRPEDPTTLAKMLALVDRLGSSVPL
                     YRLGCNMEPEAALVAYHGMNHE"
     CDS             7817..8038
                     /locus_tag="ctg47_12"
                     /transl_table=11
                     /translation="MTDLNTYFQKHGLCAENILYIHRKDRKTVIQRTDGEEFALFIPVH
                     SILSALPESEFFEHQQGNCRMPQPHCRY"
     CDS             7986..8510
                     /locus_tag="ctg47_13"
                     /transl_table=11
                     /translation="MSISKGIVVCRSHIVDISKDGVYTMSDGRTFQGRKRGLSSHRRLR
                     TEIGLAGTKPQPLSMLEKCSLLDNMPLAFCVIELVFNAEGHGVDFIFRYCNAEMANVEG
                     VPVEEMLNRSFYEVFRNGDKKWLVAYADVALNGTKRILHDYSPEIDKYLTIHCYQPEPG
                     YCACVLQVTDR"
     CDS             8636..8953
                     /locus_tag="ctg47_14"
                     /transl_table=11
                     /translation="MTQPKTDLAYLRNEKAKAEQKLRACQHREKILERQMSELNRRERV
                     HRLCTRAGMLESFLVCPGELTDDQVMELLKISFRQPEVVLALAKMVHDVHERSNVQNPL
                     E"
     CDS             9217..10794
                     /locus_tag="ctg47_15"
                     /transl_table=11
                     /translation="MPIPCPHFKITIVKRSQGQSAVAGAAYQSGERLFSEYDQKTKFYN
                     KKKELVHAEIMLPSHAPPGYADRATLWNAVEAVENQWNSQLARRIVLAFPVEVPKEQYL
                     SMIKEFCQEQFVSKGMIADFAIHDKGDGNPHAHILLTLRAMDAHGKWLPKARKVYDLDE
                     NGERIQLPSGNWRCHKENTVDWNDQKYAEIWRHSWETITNRYLEAAGRPERVDLRSFER
                     QGIQQIPTVHLGPAAHQMEKRGVETFLGNLNRDIRAANSLMQSIRSAIRGLQRWIADLN
                     EKKQLLLDALEKAKEPTLSDLLVDYFNLCNEQRSDWSGKAKLKCTVRDFEEVKRAVDYL
                     KAHSLNAIEDLDTAISNLNQTAAPLRRQLKQYENRMRAIAQIKDAAAVHAKLKPIHDAF
                     MKKNFKLTKDAYAAQHKEELDTFNKAVRTLMKLNGSTAVDFSALDAEFSALQSSSAELR
                     TQLETLQPDISALKNIRKYIDMVLNKQQLSAPGGKMPEKESVLKKLEEAKAAQSQKKTE
                     QKNHAQEL"
     CDS             10807..12672
                     /locus_tag="ctg47_16"
                     /transl_table=11
                     /translation="MTYTQAQIDKANAVDLEKFLRAQGETLVRSGKEYRWKAHDSLTVC
                     GNKWFRHSQSKGGFPVDFVMEFYGKSFPEAVQMLTGEPGEVQPEADPAPSPAFRLPLRN
                     VTNANILNYLTQEWKLSPSLVNFFIAARDIYEDAAHHNVVFVGRDADGHPRYASSRGIR
                     EKFRQDAAGAEKAFGFAHRGTDKQLLVFEAPIDLLSFIELFPKNWQQHNYLSLGGVSGK
                     ALRQFLSERPDVERVFLCLDADKAGEDACKRLAALLPDTVSVTRIQPCMKDWNDVLVHR
                     AEIPNRNYFKSIVLKEPSKPETVKIIRMSDVELTPVDWLWKPYLPFGKLSVLQGNPGEG
                     KTYFAMHLAAACTNGKLLPNMERMEPFNVIYQTAEDGLGDTVKPRLIEAGADLDRVLVI
                     DDSDVQLTLSDERIEKAIIENNARLVIIDPIQAYLGADVDMNRANEVRPIFMRLGQVAR
                     RTGCAILLIGHLNKAAGMQSLQRGLGSIDIAAAVRSVMFIGKLKHDPTMRILTHEKSSL
                     APPGLSLAFSLGDEGGFRWVGEYDITADEMLSGIEPQRETKTQQAKDLICTLIAGGKQV
                     LSEDIDKAALERGIPGRTVRDAKRELGDALKSKIVEGRKKVFGME"
     CDS             12779..12934
                     /locus_tag="ctg47_17"
                     /transl_table=11
                     /translation="MENQNSSYSVQIGKTTFIVCVKQSETAKKPIEKMFKDMCRHEITR
                     ASLRTT"
     CDS             13040..13678
                     /locus_tag="ctg47_18"
                     /transl_table=11
                     /translation="MNLFKEVADIKTADQLNLPRPTAHYETVVVKPSAYQQEMVQALSE
                     RAAAVHSGAVEPSVDNMLRITSDGRKLGLDQRLMNPLLPDDPGSKVNACVQNIVRIWRE
                     GAAEKLTQLVFCDLSTPRGKAASEKEAADVEKLLADETGSKNFNVYDDIRAKLIAQGIP
                     QEQIAFIHEANTEARKKELFAKVRSGQVRVLMGSTAKMGAGTNVRATRL"
ORIGIN
        1 ggatgctcaa tttgagcggt cgtgctgcgc aatctcgcgc ggaatactca ggcagactgg
       61 tatgaccaga tgttctattt cgtccgtgct gagatggagt gctacaccaa catgctgctc
      121 ctgatgcagg acatcgagga ggacaaggaa tggaggaagg aagattttgt cgagcccgat
      181 gacaatgttt aagctggaaa ccatgatcta cgccagcgag gacgggacaa gcagcgtatt
      241 tacgctgaat cccgccttgc agaaacagct tgccgctctt gctacacagc acccggaggt
      301 gtgccagaga aaggcaaggg gcgaagccgg tggggtgacg tatcaggtca gggatgctgc
      361 gctagctatc cagcctgtgc gggcatcctg aaagcgatac ccgatctgct atggtagaat
      421 aaagaacaac gggcaaagcg tcaggaggga tgctttgccc gttttacata cctgtatgca
      481 attatgcgga acttttagag cagtgatggc tgctcatcca gacaaagagc attgaagcgg
      541 cgaaaaaaca cgggcatccg tcttggttgc ccgcgcataa aaagaatgat acacagaagg
      601 aggatgcacg ggtgttcttt atatcatgcc tatgctactg ccgacaacga tactctatac
      661 agaattatct tctgctgacc gctttcaaag cttttatctc ctgtgtgacc ttctttcgtt
      721 tcgtaatgcc cttgtatatc aaacgccata cccagtagaa aggcagcaga actggaaact
      781 tatataccac aggagcataa cacttgcacc actccatatt tggaaacata cgggatatga
      841 tatatttacc cttggttttc gtagtgagcg gttccccatc tggctgaaat tcctgcatcc
      901 tatgaagtgt ctggttgaac agattcccgt aggtcgtcgc tcccagataa taggcaaaca
      961 tctggttctc ctcctcagtc aactcggacc tcaacacggt tttggtattt ccaaacagct
     1021 tctgtgataa cttacgactg tccctttcat aatcaaggat gcccagactc ctcaactcag
     1081 actctacata ctcccagtct aaggtcttcc ccagtttccg attcataaca taaaaatctg
     1141 ccagagtccg gatgccagtt cctccatgac tgtaatgttt gtaagcatgt gccacaacaa
     1201 acacatagaa atcctctggg gtgaagtgat accggaaagg tagcttctcg tcctgcacca
     1261 gcctgtctac gacattctca tacttctttt gaggagttga gcggtcttcg tgaaacagcg
     1321 caacatgcat ctcaaagtta tagatgggtt gcttttcata agcatcatgg ttactcttgt
     1381 tataggactc aatgctgtag cccctgttta caaaaatatc tcttacctgc tgccgtcttg
     1441 tcgcatcaaa cagaatatcg ttatctgcca tttcccgcat cccgaattta ggataccagt
     1501 ctttcagaat gctgcctttc agcggcatat accagatacc atgctctgca aattcttttt
     1561 ccagtcggtg tcgttcggca tccagcagca tatttttgcg gatcgcctta tttttgctat
     1621 ccagccattt cagccggatg ctttcctcgg cacaacgaaa cgcatcggtc tgttccagcg
     1681 ccatgcacac cattgcagaa acggaatgcg ctttcgccag ccgaagcagt gcctccatgt
     1741 caatatttgc aagcagtgtt tcttccggct ttatctcttg cagtgaacag gccatgagat
     1801 aaatcaaaag ttccgaagtc ttttccatat catgctcctt caatactcat cccaacggct
     1861 gtagattgca ctgatttttt ccttgagttc ctgaatgcgt ttttcctgct ccgcttcata
     1921 tttttcatag gattcctgcc gctcttgctg ggtggcattc tggtcggcca ctgcttgaaa
     1981 agcactgttc aggtcaacat aacgcaactc attggccgct ttccggtcgt ctgtcagcgt
     2041 cataaatctt tcaacatctg aaatctggag cgttccgttt tgaatcgttg aaaaatcaaa
     2101 cgacgcaagc atcatggtat gtgctgtaac aacttgagaa atatagtctg cgtagtagac
     2161 gggttgcttg aaaaagccat agcaaatgta tggtttccca ttttcctgca taccagcctg
     2221 caaggaagca tcatacaaga tcaattctgt atagccacgt tcattcaaaa gattccgggt
     2281 ctcttctgtg ttcaccttgt tccgaagcag gaacgcagga cttttggtat cgtccatctg
     2341 caccaacagg tctttcatct cgtccgccgt ctgcaaaatg gattcgtcaa attgcaggcc
     2401 cgccaacaca atttcatagt cttttgcaac ggcttttttc aaaatccggg tcagctgttc
     2461 tttttcctgc gaacagtcca gaaggatcac cggggtgatg gaatgttctg cagccagttt
     2521 atcgatctcg gtaaaatcgt ctgccgatgc aggaacaaaa ccaaaaagga tgccggaagt
     2581 atcttcttta gtgttgatgg cgcgttgctt ttgtgcaagc ttcgaacgaa tatcgttgat
     2641 ctcttgctca tatggcattg cttccttttg aagctgctgc atatacgctg tctgccgctg
     2701 ttcctgactg tggtttacaa agagcagtcc aaacagcacg acagcaagaa gaatgactac
     2761 gatcgataat gctttgcttt tcatttgcac gttttccttt ccctcacgca aatgccatcc
     2821 ttcgagaacg ccagttctgc atcaaagaac ccggcctgat tcatccggtg cgtgaccaga
     2881 atcaccgttt tgtccgtcat ctttcgcaaa ttattcagca gtcgaagggc tgttgcttcg
     2941 tccaatgcgc tggtcgcctc gtccaacaaa agaattggat ggttggaata taccgcccgg
     3001 gcaatggcga tgcgctgcat ctgcccttcg gacagacctg cgccgcgctc acccagcacg
     3061 gtatctagcc cgctttccag cctgcgtaca aaatcatccg cacaggcgat tttcagtgcg
     3121 ttataaattg cattctcatc ctgcgcccta tcttcatccc caaatgcaac aatgctgcgg
     3181 atggaaccgg acaaaagctg gttcccctgc ggcacatagg caaacagact tttccatgct
     3241 ggggtcagcg gttggttccc ggttttcgtg gaaaggaacc gcttgccgga atccagcgga
     3301 tacaggcaca tgagcagttt gaggagggtg cttttgccgc agccggacgg cccggtaaac
     3361 actacatact cgcccttgcg gacggtcaga ctgacatcct gcaaaaccac cggcatggcg
     3421 ggcggttcgc cctcggtctg caccgggggc tgataggtaa aacagacgtg ttccagctga
     3481 agggactgca attcggtctg ataaaaattc aaggtctgtt cttcaggcac cgtttcggtg
     3541 ctgtctgacg caaaggcttc cgcttccatc aggcgctcgg cgctggccag catggaataa
     3601 taccgcggca gatagcccgt caggttggca aacgggcttt gcacctgccc caccagctgt
     3661 ataatggcta tcaggttgcc gtagctcatg gtgccggtca ggatgccgta gccgcagaac
     3721 ccgatcccca gcagatacgc cccgtccatg gcaccggcaa agccgatgtt gcacaggttg
     3781 gaaaaattgc tgcgcttcat ccgggcggct ttgtgggcgt ccatcagggc gtctgcctgc
     3841 tgcgccatct gttcttcctt ggcaaaggtg cggacgatga caagactttc cagccgctcc
     3901 tgcaagaaca cccggagcgc gccgtctgtt tcttgaatcc tcttgtgcag tcgtttcaat
     3961 atcttgcgga acgcataggt cagcagcatc atggccgcgc cgccggggag aaggatgtac
     4021 aaaaaacgcg gctcgagcca caaaatagcg gcgactgcgc ccagcaagcg caccagcatt
     4081 ccgaccagac cgggcacgat ctgggtcacg ccgcccgcca ccacggtggt atccgaggtc
     4141 aggcggttca tccactcgcc ggagtgcacc gccgccactg acgcataatc gccggtaagc
     4201 agggcggaga agagccgatg cttaaagcgg ttttccacgg cggcgctggt gtactcgttt
     4261 aaaaagcgac tcgccgcgct caacatgatc tgccccagca ggatgcccac cagcagcgcc
     4321 agcgatgccc aaaaaccgcc ctgtaccccg tccacggcca tattgatgat gcgccgcagt
     4381 acaaacgcaa aggcgatgct ggaaacactc agcaccgcct gtattgcgac cagaacgcct
     4441 accagaagct tggtttttcc cgctacgatg ctgagccatt gtaaggtatt tttttgtttc
     4501 attggcacag cttccttttt attcttccgg gcaggtcacg gcaccacagc accgctgcgc
     4561 gcaggtagaa caaatcgcac cacagatgca catacagccg gtagcgctga tccgtgaccg
     4621 ggagcttttg cccatcccgg attactgccg tcagcacgcc gatgatatgt cggtcggtaa
     4681 tgcctatctc ccgccgccag cggttgtctc cgcagaggac gtaatcattt ttacgcactt
     4741 tcaaaatacg gtggagcaca tattgtccgc tgtctcggcg gtagagcggc acatcgtatt
     4801 tgttcagccg tccttgcggt ttgcgggcga taagcagcag gtctttgccc tgccggatca
     4861 gcggcagcat actgtcgcct acattgcggt aaagcaaaaa gccattgtgc gtgatctcct
     4921 cctcaaaggt cgatttacgc atccagcgca ccaatttttt tcaggttggc cagcaccatg
     4981 tccacatcct cagccatcac agcgcggggg gcatcgtact ttttgcacat ggcatccaga
     5041 atggcttcct tggtggtttc ggttttgagc tggtcgatga taaacgcggc ggtggcgttg
     5101 ctgcgcacca tgccggcaaa gccgccgtcc gcttccacca tcacctgctc gccgtccatc
     5161 tcctgcgtca caaaggtatc tttcagtttc atattcaaac gtcctttctt agaacggtgt
     5221 tttttcaaga gaaggcagac cgccgaagca gactgccttc ttctaacgtg tcatcagtcg
     5281 ccccaaatac atttatcgct gggatctggg gtaatagtat catagtctgt actggtgcag
     5341 atcttgatgc tagatgtcgt gatgacatcc tcggcctcaa actcgatgac ttccatctga
     5401 gccttggtgt acttttccat gtttacacac ctcctttcgc agaaaatctc tatgtgaaac
     5461 agctgctatg ctgcgtcacg caaagggtca gcagtccgag tgaggttctt cctcactgat
     5521 ctgctctttt ttcagccatg cctcgtaagt gttgcgcata gcggataatg tatcttcccg
     5581 aaccttaatc tgcatttgct cgtagcactt ttgctgctca atacattttt tcaaccggat
     5641 gcattccgga tagaaaaaac atttcctgca cgcatccaaa gccggccacg attcccggaa
     5701 actttgccgc acggattcgt ccagcttttc gctgtctata tgcccgataa agttgttctc
     5761 gctatattgc tcacacaagc ccaattcgcc gtttggcaag atggtaagtg caccaccatg
     5821 gtctgcaata caacgccgaa gcggaaggtc ttttcgtaaa cccaatttct ttacatatcc
     5881 aagggtcacc agcttatgat acaacgcctg ctgtttctga tagagcttat ttcggctgtc
     5941 cgctggaata ccctctttgc aacccagaaa ctcatataac acatggctgt aaaccgtcag
     6001 ctttttgttt tcaccaaact gttcatgcaa ttcatccgcc agttccatca gattatcggc
     6061 gttgtgctcg tccatgttca gccggataag aaccgcaacc cctgcatcca gcaaacgccg
     6121 gatatttgcc agtaccacct gataggggct tttgccattc ttataaataa atgccttgct
     6181 gcggttataa atctcttccg tgccgtccag cgtgatctgc acgctcttca acttccaatg
     6241 ggaaaccgct tgttctacgg tagcgccgtc aaacagatac ccattagaga tcatcatgga
     6301 ttcgtacaca atgccctttt ccgtaaggtt ggtgcagatg atgtcaatga cctgcttatt
     6361 aaaagcggct caccgccaaa ccagtgcaga tgaacctttt cgccgccgca atgcgctgca
     6421 atataagccg ccgccttatg ggcggtttcg ttgctcatgg gaatccggga acgtcccatc
     6481 tcatagcagt aaaagcaccg ggcgttgcag tctgtggtgg taaagatggt ataagtagtt
     6541 gtatgctccg gttccttctg catcgtgcgg cggataaacc gtacctggtc ggcatatttc
     6601 atgtcgtcca tctcctgcgg tacgcgaaac cagctgctgc gcagttcagc aaccacatcc
     6661 ggtgcggtat actcttcctg cgtgagcaga agcagcgccc gtgtgagggt atggaacacc
     6721 agcaccccgc cctcgactgg ctgggcaaga acgtatgtca tccagcgcag accgtgctct
     6781 gccagtttcg gcttgccaag gatcttgatt gtattgccag acggcggcaa aatggtttgc
     6841 atatgcgttt cctctattcg tggttcattc cgtggtaggc cacaagtgcg gcctccggtt
     6901 ccatattgca gcccagccgg tacagcggca cgctgctgcc caaccggtct accagagcca
     6961 gcatttttgc cagcgtcgtc gggtcttccg gacggtagac ctgctggcag agcatggaca
     7021 gcgcttcctt ttttgagatg cgctcgatgt ggtttgtctc gctccgggtc aggatgcaga
     7081 gtgctttgag cggacaggaa gtgttggtgc tcaggtgctc cttgccgtcc cacggagtac
     7141 cgtagacggt cacgccctcg ttcgtaatgt gaagcagggg cttgtccccg ttgaccatca
     7201 cggcgcggtc gccaaactgc tgcatccaca accgggtgtg ggtggttttg cctgtgccgc
     7261 ttttggccgt gaacagatac gcctgcccgt ctaccgccac cacggcaccg tgcatcagca
     7321 ggatatcgtc ctgcaccagc agctgcgcca gcttgcggta gaccgccagc gtttccagat
     7381 agggttctgc gtgctcccgc accgccgcgc cttccaactc gtctgcccgc gcagagcgct
     7441 gccgctcgta ggcaatgtcg gcttctgttg tcgtaataac atattctggg ggatcgtctg
     7501 tccgatagtc cgcgcacagc gtatgtacct gcggatagac cgattcaatt tctacggtat
     7561 gccccgccag ccggtaagta ttatgcattg tgcgctcctt ataggatatc aagtcgatca
     7621 atatgcttat tatacacgaa cagcatttaa aagtcaagaa tatatcgaaa aaatgcacaa
     7681 cgcaagaatg actttttaga agaacttgct caacaggttg aataaacgtc atgataaaac
     7741 gaactttagc gaacttattg cgcctccagc catggtgtgg tatactggac acatcaactg
     7801 aaaaaggggt gcctctatga ccgatctgaa cacatacttt caaaagcatg gcctttgtgc
     7861 ggagaacatc ctgtacattc accgcaaaga ccgcaaaaca gtcattcagc gcacggacgg
     7921 tgaggagttt gcactgttca taccggtaca tagtattctg tccgctttgc cggaaagcga
     7981 gttttttgag catcagcaag ggaattgtcg tatgccgcag ccacattgta gatattagta
     8041 aggacggcgt ttataccatg tcggatggcc gcacttttca aggacgcaaa cgcggcttga
     8101 gcagtcatcg ccgcctgcgc acagaaatag ggctggcagg cacgaagccc cagcccctga
     8161 gtatgctgga aaaatgcagc ctgctggaca atatgccgct ggcattctgt gtgatcgagc
     8221 ttgttttcaa tgcggaggga catggcgtgg atttcatctt ccggtactgc aatgcggaaa
     8281 tggcgaatgt ggaaggcgtt cccgtggaag aaatgctgaa ccgctcgttc tacgaggtct
     8341 tccgtaatgg cgacaaaaag tggctggtgg cttatgcgga tgttgcactc aatggcacaa
     8401 aacgcatcct ccacgattac agcccggaaa tagataagta ccttaccatc cattgctatc
     8461 agcccgaacc cggctattgc gcctgtgtgc tgcaagtgac ggatcgataa atcgaataaa
     8521 aaagcaatat atgtccttgc cccgcgctgc cagtgccttt cttagatatg attggacgca
     8581 attgcttgtt tgtgacaagt tattttgaaa ttacaagaaa taaggagcga tgccattgac
     8641 ccaacccaaa accgatcttg cctacctccg caacgaaaaa gccaaagcag agcagaagct
     8701 gcgcgcttgt cagcaccggg agaagatcct tgaacgccag atgtcagagc tgaaccggag
     8761 agagcgtgtg catcgccttt gcacccgtgc cggaatgctg gaaagctttc tggtctgtcc
     8821 gggagaactg accgatgatc aggtgatgga actgctgaaa atctcgttcc gccagcctga
     8881 agtcgtgctg gcgcttgcaa agatggtgca tgatgttcac gaacgcagca acgtccaaaa
     8941 ccctttagaa taaagggcgc aattatacac cgttccggtg aaattgcggt cttgcagacg
     9001 gctcgatgaa atcgaagctg gcgtttgtgc gccagcccga ttccatccca aggaaaactg
     9061 cattttcctt gcgctgcttt gcagctatcc ttttgcggct cccgcctgag accgaagcgc
     9121 acagcactcc gctccaaggc ggcgagcaaa accgaatacg attccagacc gttcatcaag
     9181 agcaatcttg ctgggcggtc tttttgtttg ggggtgatgc ctattccgtg tccgcatttc
     9241 aaaattacca tcgtcaagcg cagccaaggg cagtccgctg ttgccggggc cgcttaccag
     9301 agcggcgaac ggctgttcag cgagtacgac cagaaaacaa aattctacaa caagaagaaa
     9361 gaacttgtcc acgctgagat catgctgccg tcccatgcgc cgcccggata tgcagaccgg
     9421 gcaaccctct ggaacgccgt ggaagccgtg gagaaccagt ggaactccca gcttgcccgg
     9481 cgcatcgtgc tggcgttccc ggtggaggtg ccgaaggagc agtatttgtc catgataaaa
     9541 gagttttgtc aggagcagtt tgtttccaaa gggatgattg ccgactttgc catccacgac
     9601 aagggagatg gaaacccaca cgcccacatt ctgctgacgc tccgggcaat ggacgcgcac
     9661 ggcaagtggc ttccaaaagc ccgaaaggtc tacgacctcg acgaaaacgg tgagcgcatt
     9721 cagcttcctt ctggcaactg gaggtgtcac aaggaaaaca cggtggactg gaacgaccag
     9781 aagtacgccg agatctggcg gcatagctgg gaaaccatca ccaaccgcta tttggaagcg
     9841 gctggccgcc cggaacgtgt tgacctgcgc tcctttgagc ggcagggcat ccagcagata
     9901 ccgaccgtgc atctcggtcc cgccgcacac cagatggaaa agcgcggggt ggaaaccttt
     9961 ctcggcaatc tgaaccggga cattcgagcc gccaacagcc tgatgcagtc catccgcagt
    10021 gcaattcgtg gactgcaacg ctggatcgca gacctgaacg aaaagaagca gcttcttctg
    10081 gacgctctgg aaaaggcgaa agaacccacg ctgtccgact tgctggtgga ttacttcaac
    10141 ctttgcaacg agcagcggag cgattggtct ggcaaggcaa aactgaaatg cactgtccgg
    10201 gactttgagg aagtcaaacg ggcggtggac tacctgaaag cccattctct gaacgccatc
    10261 gaggatttgg acaccgcaat ttctaacctg aaccagactg ccgcccctct ccgcaggcag
    10321 ttgaagcagt acgaaaaccg tatgcgggca atcgctcaga tcaaggacgc cgccgccgtc
    10381 catgccaagc tgaagcccat ccatgatgcc tttatgaaga agaacttcaa gctgaccaag
    10441 gacgcttacg ccgcccagca caaggaggaa ctggacacgt tcaacaaggc tgtccgcacc
    10501 ctgatgaagc tgaacggcag cacagcggtg gatttttcgg cattggatgc cgaattttct
    10561 gcgctgcaat ccagcagcgc agagctgcgc acccaactgg aaaccttgca gccggacatc
    10621 tctgccctga aaaatatccg caagtatatt gacatggtgc tgaataagca gcagctttct
    10681 gcaccgggcg gtaagatgcc ggagaaggaa tcggtgctga aaaaactgga agaagccaag
    10741 gcagcgcaat cccagaagaa aaccgaacag aagaatcacg cacaggagct ttaaggagga
    10801 agcagcatga cctacaccca agcccagatt gacaaagcca atgcggtgga tctggaaaaa
    10861 tttctccggg cacagggcga aacgctggtg cgcagcggaa aagaataccg ctggaaagcc
    10921 cacgacagcc tgaccgtctg cggaaacaaa tggttccggc acagccagag caagggcggc
    10981 tttccggtgg atttcgtgat ggaattttac ggcaagtcct tccctgaagc ggtgcagatg
    11041 ctgaccggag agccgggcga agtccagccg gaggctgacc ccgccccctc tccggcgttt
    11101 cgcttgccgc tgcggaacgt caccaacgcc aacatcctga actatctgac gcaggagtgg
    11161 aaactcagtc catcactggt gaacttcttc attgctgcca gagatattta tgaggacgcc
    11221 gcccaccaca acgtggtctt tgtggggcgg gatgcagacg ggcatccccg ctacgcaagc
    11281 agccgtggga ttcgggaaaa gtttcggcag gatgcagccg gtgcagaaaa ggcatttggc
    11341 tttgcccatc gtggcaccga caaacagttg ctggtctttg aagcacccat cgacctgctg
    11401 tccttcatcg aactgttccc gaaaaactgg cagcagcaca attatctgtc gctgggcggg
    11461 gtgtcgggca aggcgctgcg gcaattcctc tcggaacgcc cggacgtgga gcgggtgttc
    11521 ctctgtctgg atgccgacaa agccggagag gatgcctgca agcggctggc ggcgctgctg
    11581 ccggacaccg tgagcgtgac ccgcatccag ccctgcatga aggactggaa cgacgttctg
    11641 gtgcaccggg cagagattcc gaatcgcaat tatttcaaga gcatcgtgct gaaagagccg
    11701 tcaaaaccgg aaacggtgaa gatcatccgc atgagcgacg tagagctgac cccggtggac
    11761 tggctctgga aaccgtatct gccatttggg aaactaagcg tgctgcaggg caatccgggc
    11821 gagggcaaga cctactttgc tatgcatctt gccgccgcct gtaccaacgg aaaattgctg
    11881 cccaacatgg agcgcatgga acccttcaac gtgatctacc agaccgcaga ggacggtctg
    11941 ggcgatacgg tcaagccccg cctgatcgaa gcgggtgcag accttgaccg ggtgctggtc
    12001 attgatgaca gcgatgtgca gttgaccctc tctgacgaac gaattgaaaa agccattatc
    12061 gagaacaacg cccgactggt catcatcgac ccgatccagg cgtatctcgg tgccgatgtg
    12121 gacatgaacc gggcgaacga agtccggccc atcttcatgc ggttgggaca ggtagcgcgg
    12181 cgaacaggct gcgctatttt gctgattggg cacctgaaca aggccgctgg aatgcagagc
    12241 ttgcagcggg gcctcggctc catcgacatt gccgccgccg tccgcagcgt catgttcatc
    12301 ggcaagctga aacacgaccc caccatgcgc atcctgaccc atgaaaaaag ctcccttgcc
    12361 ccgccgggct tgtcgctggc gttctctctg ggggatgagg gcggtttccg ctgggtcggc
    12421 gagtacgaca ttaccgcaga cgagatgctg tccggcatcg aaccgcaacg tgaaaccaag
    12481 acccagcaag ccaaagacct gatctgcacc ctgattgccg gaggaaagca ggtgctcagc
    12541 gaggacatcg acaaggcggc tctggaaagg ggcatccctg gcagaactgt ccgggatgcc
    12601 aaacgggaac tgggcgatgc cctgaaaagc aaaatcgtgg aaggccgcaa gaaggtcttt
    12661 gggatggaat aagccatttg gctggcagaa aattttgtct ggcaagaaaa tcatggtaca
    12721 cccacagttg ccagtctgcc aggcaaattc agaaaatgac gataaaagga gaaattcaat
    12781 ggaaaatcag aattcgagtt attcggtgca gattggtaaa accaccttta ttgtgtgcgt
    12841 gaagcagtcc gaaactgcca aaaagccgat tgaaaagatg ttcaaggata tgtgtagaca
    12901 cgaaatcaca agggcttcct tgcggacaac ctgatgaatt tagaaaaatt accgaaaacc
    12961 tcttgacgaa gcctagcccg aagggacggg ctatcgggcg cggacgcgct ttgcaaagtt
    13021 tttcaacctc ccggagctga tgaacctttt caaggaagtt gcggacatca agacggctga
    13081 tcagctgaat ctgccccgac cgaccgcgca ctacgaaacg gtggtggtga agccgtctgc
    13141 ctatcagcag gaaatggtgc aggcgctttc ggagcgggcg gcagcggttc acagcggcgc
    13201 ggttgagccg agcgtggaca acatgctgcg catcacctcc gacgggcgga agttagggct
    13261 tgaccagcgg ctgatgaatc cgcttcttcc ggatgatccg ggcagcaagg tcaacgcctg
    13321 cgtccaaaac attgtccgca tctggcgcga aggcgcggcg gaaaagctga cacagctggt
    13381 tttctgcgac ctgtccaccc cgcgcggcaa ggcggcttcg gagaaggaag cagcggatgt
    13441 ggagaagctt ctggcggacg aaacgggcag caagaacttc aacgtgtatg atgacattcg
    13501 cgccaagctg attgcgcagg gcatcccgca ggagcagatt gcctttatcc acgaagcgaa
    13561 cacggaagcg cggaagaagg agcttttcgc gaaggtacgc agcgggcagg tgcgcgtcct
    13621 gatgggcagc acggcgaaaa tgggcgcggg aacaaacgtt cgtgcgactc gtttgtaact
    13681 gaaaaggtta cgctcaagtc aaaattctgc aagat
//
