LOCUS       gnlProkkaPJNHMONN_63   12271 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PJNHMONN_63.
ACCESSION   gnlProkkaPJNHMONN_63
VERSION     gnlProkkaPJNHMONN_63
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 22:35:01
            Original ID  :: gnl|Prokka|PJNHMONN_63
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12271
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12271
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[8397:9723]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8398..9723
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..12271
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12271
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(551..2503)
                     /gene_functions="other (smcogs) SMCOG1162:threonyl-tRNA
                     synthetase (Score: 759.9; E-value: 3e-230)"
                     /gene_kind="other"
                     /locus_tag="ctg63_1"
                     /transl_table=11
                     /translation="MIIRLKDGSEKEYAQPMSVLDIAKDISEGLARNACAGQVNGETVD
                     LRTVVSEDSDLNILTFNDEEGKLAFRHTASHVLAQAVKRLYPEAKLAIGPAIEDGFYYD
                     FDMAPLTREDLDAIEKEMKKVIKENPPIERYELPREEAIAYMKEKDEPYKVELIEDLPE
                     DATISFYKQGDFTDLCAGPHLMSVKPIKAFKLTASSGAYWRGNENNKMLTRIYGTAYTK
                     KADLEERLKYLEEIKLRDHNRLGREMELFTTVDVIGQGLPLLLPKGAKIIQTLQRWIED
                     LEDNEWGYVRTKTPLMAKSDLYKISGHWDHYKEGMFVLGDEENDKEVLALRPMTCPFQY
                     YCYKNTQKSYRDLPYRMSETSTLFRNEDSGEMHGLTRVRQFTISEGHLIIRPDQTNDEL
                     KGCLHLAQYCLGVLGVQDDVTYRLSKWDPNNKEKYLGDDEYWETTQDAIRNILVDQGVP
                     FVEAEGEAAFYGPKIDIQAKNVYGKEDTMITIQLDCAIAENFDMYYIDQNGDKQRPYVI
                     HRTSMGCYERTLAWLIEKYAGKFPTWLCPEQVRVLPISEKFADYAEEVNKELKRNGILS
                     TVDNRSEKIGYKIREARLQKLPYMLVVGAQEQETGKVSVRSRFAGDEGQKDLKDFISAI
                     CEEIRTKEIRQEVEE"
     CDS             3609..4355
                     /locus_tag="ctg63_2"
                     /transl_table=11
                     /translation="MYQFFIQPDSIKEEEIWIADPQDVNHIRNVLRMKKGEKVSLCCEA
                     KGKEYICSIEEIESDIVKAAIIDINGESRELPVKITLFQGLPKSDKMELIIQKAVELGV
                     AEIVPMATKRAVVKLDAKKAAKKVQRWNEIAKSAAKQSKRGLIPEVKPVMSFKEAVEYG
                     KSMDMLLIPYEDAKGIAHSREVVETVKDKKSLGIYIGPEGGFPEEEVSLAMKAGAEPVT
                     LGHRILRTETAGMTLLSILMFMLEED"
     CDS             4442..5551
                     /locus_tag="ctg63_3"
                     /transl_table=11
                     /translation="MAGSSFGTLFCMTTWGETHGKGVGVVVDGCPAGLSLCEEDIQKYL
                     NRRKPGQSKYTTKRKEDDKVEILSGVFEGKTTGTPISMAVFNKDQHSKDYSAIKDIYRP
                     GHADYTFDKKYGFRDYRGGGRSSGRETTARVAAGAVAAKVLKELGIEVFAYTKAIGPVQ
                     IDENRFSKEERDKNALYMPDAQAAAQAEEYLQEKMKELDSCGGIVECVITGMPVGVGEP
                     VFDKLSANLGKAILSIGAVKGFEIGDGFAAAASAGSENNDDFYNDNGTVKKKTNHAGGV
                     LGGMSDGSVITFRAAFKPTPSIAQPQQTVNRDGKDTEIVIHGRHDPIIVPRAVVVVETM
                     AAVTVLDLLLQNMGSRLDSVKNFYENEKK"
     CDS             5620..6762
                     /locus_tag="ctg63_4"
                     /transl_table=11
                     /translation="MYKLLTKDGMAKRGEFETVHGTIQTPVFMNVGTVGAIKGAVSTDD
                     LRTIGTQVELSNTYHLHVRTGDKLIKQFGGLHKFMGWDKPILTDSGGFQVFSLSGLRKI
                     KEEGVYFQSHIDGHHIFMGPEESMQIQSNLGSTIAMAFDECPSSRADRTYIQNSVDRTT
                     RWLERCKKKMQELNSLPDTVNPHQMLFGINQGGVFADIRIEHAKRISELDLDGYAVGGL
                     AVGETHDEMYYILDEVVPYLPENKPTYLMGVGTPANIIEAVDRGIDFFDCVYPSRNGRH
                     GHVYTHHGKLNLFNKKFELDPRPIEEGCQCPSCRTYSRAYIRHLLKAKEMLGMRLCVLH
                     NLYFYNHLMEEIRGAIDEHRYKEFKKTTLEGFLTPEEEYR"
     CDS             6796..7116
                     /locus_tag="ctg63_5"
                     /transl_table=11
                     /translation="MLLAQSASASSSITMIIAYVILFGAIIYFMTIRPQKKQQKAADEM
                     HAGMQAGDSVLTTSGFYGVIIDIMDDTVIVEFGNNRNCRIPMQKDAIAAVEKPNLTKTE
                     EE"
     CDS             7463..7852
                     /locus_tag="ctg63_6"
                     /transl_table=11
                     /translation="MQPMDGISYKKWMERAAGLFLSALIAVLLTMLFLAVFAFAMLKGN
                     LSASVEKIGLIVMSVMACFVGGFLCGKKNMKKRYLWGLGVGVLYCLFFGVIRVGMGQAF
                     VTDTTAFFTMMLYCAAGGMLGGMLS"
     CDS             8398..9723
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_7"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 6.5e-25,
                     bitscore: 76.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2e-16, bitscore: 49.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.8e-14, bitscore: 43.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 9.9e-21, bitscore:
                     63.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVCSGAIHVVDDVTYDVIALYEEKSLEEIENELSYSKEDIEEAY
                     KEVTSLKEEGLLFTEDIYEDYIKEVKSRKTVVKALCLHIAHDCNLACRYCFAEEGEYKG
                     HRELMSAKVGKAALDFLVANSGNRHNLEVDFFGGEPTMNFGVVKEVVEYGRSLEEKHNK
                     HFRFTLTTNGVLLNDEIMEFANKEMDNVVLSVDGRKEIHDYMRPTRNGKPSYDLIMPKF
                     IRFAESRHQQKYYVRGTFTNRNLDFSKDVLHLADLGFEQISMEPVVGQPEEPYAIQEKD
                     LPQIFDEYDRLAKEMIKREKAGKGFNFFHFMIDLTGGPCVAKRLSGCGSGTEYLAVTPW
                     GDLYPCHQFVGEEKFLLGNVFDGIKRTDICDEFRSCNVYTKKKCKDCFARFYCSGGCPA
                     NSYNFHGTIDDSYDLSCDMERKRVECAIMIKAALADTEGEEE"
     CDS             9724..11499
                     /locus_tag="ctg63_8"
                     /transl_table=11
                     /translation="MEKWFIASKRADFNKIGEIFHISPVTARLMRNRSLTTVKEMQRYL
                     YGSLSDLYDSHLLKDADKGAEIIKEKIETGKKIRIISDYDVDGVSSNYILYQGLKRCGA
                     DVDYKIPDRVEDGYGINEHLIEKAAGDGIDTIITCDNGIAAAEQIAYGNSLGLTLIVTD
                     HHDIPFQRQEDGSISYNLPSAAAVINPKQKDCPYPFENICGAVVVYKFIQVLYDLFGID
                     RRESEAFLEIAAMATVCDVMPLCDENRIIVKEGLRRIQHTNITGLQALIEANHLEEKKI
                     SSYHFGFILGPCINASGRLTSAKDALELLLCEDKELCRQKAEALTQLNTERKEMTANGV
                     KAAKEYLESTGHANDKVLVVYLPNCHESIAGIIAGRMKEHYHKPVFVITRTKEGLKGSG
                     RSIEAYHMYKEMNKIKECFDKFGGHPMAAGFSMQEDRLEEFREKLNANATLTEDDFAEK
                     VHIDVALPISYLSESLINEFELLEPFGNENTKPLFAQKDLYIKGMRVLGTTGRCLKLFL
                     SDANGTSIDAMYFGESDVFLEELISFCGKEEAQRIQKGLSHHIWMDVTYYPQVNEWRGQ
                     KNIQIVIQNYRFKNL"
     CDS             11670..12269
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179:hydrolase (Score: 93.6; E-value: 2.5e-28)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_9"
                     /transl_table=11
                     /translation="MEQEKKQPDVRLIGLDLDGTTLTSDKVLTPHTKEVLEKCLAEGIQ
                     VLPATGRVKSGIPEYLTQIEGMRYVILSNGASVLDLKEDKVLYQNCIPWERALELFDVL
                     ETYDTFYDIYALGAGWCEARFYDNVENYGIEKHIEKLVRTSRNRIDDLREWMKENKAPV
                     EKINMFFAKEEDRQRAFRELGKIEDLAVTCSLGNNLE"
ORIGIN
        1 gtgcaacgca tattatatta tcataacagt agagttgcgt caagcatttt ttgaagattt
       61 ttttatttta tcaacaagca ctagatattg tacttttttt gtatttttat catttacacc
      121 acatatgcgg tttgttaaat tgttattttt ttatcaattc cacaaacttt ctaactcata
      181 ttttcctaat aaattccaat ttatcgttac catagtcaca agggataccc tcaaccaaac
      241 acacccaaag gaagtcataa acaacacagc tccatagaaa ccaaatactc ccttatttgc
      301 aacctcaaag ctacgaggct tttcatagag gatacctcta ccgcaacctc aaatctcctc
      361 aaaagaatac ttgattacct gaagttatca cagcacagtc tcatagaaga taaataatcc
      421 ctatttgtaa cctgggaaca agtgttggat gcgagcgcta aagcgaacat tcaacacgcc
      481 gcgacgaaag tcacaaatag ggattattta tcttctataa ggcgtctatt ctatcagagc
      541 acaagtattt ttactcctct acttcctgac ggatttcttt tgtacgaatt tcttcacaga
      601 ttgcagagat aaaatctttt aagtctttct gaccttcatc tcctgcgaaa cggcttctta
      661 cagatacctt acctgtttcc tgttcctgcg cgcctactac taacatatat ggaagcttct
      721 gaagacgtgc ttcacgaatc ttgtagccga ttttttcgga acggttatct acagtactta
      781 aaataccatt tctcttaagt tctttgttta cttcttctgc gtagtcagcg aacttctcag
      841 aaattggcag cacacgcacc tgttctgggc aaagccatgt agggaactta cctgcatatt
      901 tctcgatgag ccatgcaagt gttctctcgt agcatcccat agatgttctg tgaataacgt
      961 atggacgctg tttatctcca ttctggtcaa tgtagtacat atcaaagttc tctgcgatag
     1021 cacagtcaag ctgaattgta atcatcgtat cttctttgcc atatacattc ttcgcctgga
     1081 tatcgatctt tggtccgtag aatgcagctt ctccttctgc ctcaacaaaa ggtacaccct
     1141 gatctactaa aatattacgg atagcatcct gtgttgtctc ccaatattca tcatccccta
     1201 aatatttttc tttattatta ggatcccatt tagaaagacg gtatgttacg tcatcctgca
     1261 caccaagtac tccaagacag tactgtgcta aatgaaggca tccttttaac tcatcatttg
     1321 tctggtctgg acggataatt aaatgtcctt ctgaaatagt gaactgacgt acacgagtta
     1381 atccatgcat ttctccggaa tcttcgttac ggaaaagtgt agatgtctca ctcattctat
     1441 aaggaagatc acggtaagat ttctgtgtgt tcttgtagca gtaatactgg aatggacatg
     1501 tcattggacg aagcgctaat acttctttat cattttcctc gtcaccaagt acgaacattc
     1561 cttctttgta atgatcccaa tgtccggaaa tcttgtaaag atcactcttt gccattaatg
     1621 gagtctttgt tcttacataa ccccattcgt tatcctctaa atcctcaatc catctctgta
     1681 atgtctggat aatctttgct ccctttggaa gaagaagtgg aaggccctgt ccgataacgt
     1741 caactgttgt aaataattcc atttcacgtc caagacggtt atggtcacga agcttgatct
     1801 cttctaaata tttcagacgt tcttctaagt ctgccttctt tgtgtaagct gttccgtaaa
     1861 tacgagtgag catcttgttg ttctcattac ctcgccagta agctcctgaa gaagcagtaa
     1921 gcttaaatgc tttgattggc tttacactca ttaaatgagg tcctgcacaa agatctgtga
     1981 aatcaccctg tttataaaag ctgattgtag catcttctgg taaatcttcg ataagctcta
     2041 ctttgtaagg ctcgtctttt tctttcatgt aagcgatagc ttcctctctt ggaagttcat
     2101 atctctcaat tggaggattc tccttaatta ccttcttcat ctctttttcg atggcatcta
     2161 aatcttctct tgtaagtggt gccatgtcaa agtcatagta aaatccatct tcaatcgctg
     2221 gtccgattgc aagctttgct tctgggtaaa gacgctttac agcctgtgca agtacatgag
     2281 aagctgtgtg acggaacgca agcttacctt cctcatcatt aaatgtaaga atatttaagt
     2341 cgctgtcttc ggaaactaca gtacgaagat caactgtctc tccgtttacc tgtcctgcac
     2401 atgcatttct tgcaagacct tcgctgatat cctttgcaat gtcaagtacg gacattggct
     2461 gtgcatattc tttttcagaa ccatccttta aacgaataat catttttgtt ctttctcctt
     2521 ctatctattg tggtgtatct gtgcgttaat gcatttgcaa ctatataaaa atgcacacac
     2581 tgactcatta tgctataacc ataaatattc tatcaaacaa cgggtagcaa ttcaactata
     2641 tttctattta attcattaag aacagacgcc cgagaagaga accgataccc tatatttgcg
     2701 actttagtcg ctgcgagaaa tcgtcttcta tgaaaaggcc gacattttac tacagtctcg
     2761 tagctccgag gccacaaata tagggtattg gttctcttct cgggctgtct ttggctggat
     2821 tttgatcgaa ttaagatagt ggttgtgggg atttgaggga gcaggtagaa gttttctgct
     2881 tgctctcaga atattgtgaa tagatatttt gtatttaaat gaaaatggta atgagttgag
     2941 attaataaca acagtctgct ttttgttctg aaattattga atattgctgt gataatcatt
     3001 gaaaaagagg gatttctata ttttttaagt tccgttttta tgagttatat atacatacct
     3061 atggttattc cataaaaatt agataaagaa ctagatttta accaagtctg gcatgattat
     3121 cttatgttat ccgcattatt tataaaatca aatttaaaat atcaattttt tgtctctata
     3181 tctatatcta gtcaaatcat atcttccata tcccagtctt tcaagtagtc taagcatcta
     3241 agcattagat agattactct atctgccaaa tcataccctc catatcccaa tcattctcga
     3301 gtaagtagaa gacttggcat ctcatcccca aatcctccca ccttctctta attcatcctc
     3361 tccagccaca gcacagaagc cattgccccc aataaggcat atttgtggtc tcggagcaag
     3421 gtttggatgc gagcgggtaa gcgaacattc aaaccgccgc gactaaaatc acaaatatgc
     3481 cttattgggg gcaatggctt cgtctgtagt tcgcttaatg aattaaatag taaattgaca
     3541 tattttttga aagcggttat gatatattat gtctgcctta tagggcaaag aatgaagtgg
     3601 aggagtttat gtatcagttt tttatacagc ctgatagtat taaagaagag gagatttgga
     3661 ttgcagaccc gcaggatgta aatcacattc gtaatgttct ccgtatgaaa aagggagaaa
     3721 aagtttctct ttgttgcgaa gcaaagggaa aggagtacat ttgtagtata gaagagatag
     3781 aatcagatat cgtcaaggcg gcaattattg atattaacgg agagtcgaga gaactgccgg
     3841 taaagattac gctttttcaa ggacttccaa agagtgacaa gatggaactt atcattcaaa
     3901 aagcggtaga actcggggtg gcagagattg tgccgatggc aacaaaaaga gcggttgtaa
     3961 agcttgatgc gaagaaggcg gcaaagaaag tacagcgatg gaatgagatt gcaaaaagtg
     4021 cggctaagca gtcaaagaga ggtctgattc cagaagtaaa gcccgtaatg tcttttaaag
     4081 aagctgtgga atatggaaag agtatggata tgctactcat tccgtatgag gatgccaagg
     4141 gaatcgcaca ttccagagaa gtggtagaaa cagtaaaaga taaaaagagt ctgggaattt
     4201 atatcggacc ggaaggtggt tttccggaag aagaggtttc tcttgcgatg aaagcaggag
     4261 cagaaccggt tacacttggg caccgcattt tgcggacgga aacggcagga atgacattac
     4321 tttctatatt aatgtttatg ttagaagaag attgatttgg tgtagatagt agaaatttaa
     4381 ttgatgaaaa gtcaaacaga ggatactctg tttgacgata gaattttaac aggaggacaa
     4441 aatggcaggt tcatcatttg ggacattgtt ttgtatgaca acatggggag aaacacacgg
     4501 aaaaggtgtg ggtgttgtag tggacggttg tccggcaggc ctttctcttt gtgaggagga
     4561 tatacagaag tatttgaata gaagaaagcc gggacagtca aagtacacaa caaagcgaaa
     4621 agaagatgat aaggtggaga ttttatcggg agtttttgag ggaaagacaa caggaactcc
     4681 aatttctatg gcggtattta ataaagacca gcattcaaaa gattactctg caatcaagga
     4741 tatttaccgt ccgggccatg cagattatac atttgataag aagtatggtt tccgtgatta
     4801 tcgcggtggc ggccgttctt caggaagaga gacaacagca agagtagcag caggtgcagt
     4861 agcagcaaaa gtattaaaag aacttggcat tgaagtattt gcttatacaa aagcaattgg
     4921 gccagttcaa attgatgaaa atagattttc aaaagaagaa cgagataaga acgcattata
     4981 tatgccggat gcacaggcag cagcacaggc ggaagagtat cttcaggaga aaatgaaaga
     5041 gttagactcc tgtggtggca ttgtggaatg tgtaattaca ggaatgcccg tcggtgttgg
     5101 tgagccggta tttgataaat taagtgcgaa tcttggaaaa gcaattttat ctatcggagc
     5161 agtaaaaggc ttcgaaatcg gagatggatt tgcggcggca gcaagtgctg gttctgagaa
     5221 taatgatgat ttttataatg ataatggtac ggtgaaaaag aaaacgaatc atgcaggtgg
     5281 tgtgcttggt ggaatgagcg atggttcagt aattacattt cgtgcagcat ttaagccaac
     5341 tccatcgatt gcacagccac agcagacagt aaatagagat ggcaaagata cagaaattgt
     5401 aattcacgga agacatgacc cgattattgt gccaagagca gtcgttgttg tagagacaat
     5461 ggcagcggta actgttcttg atctgctgct tcagaatatg gggagccgct tagatagcgt
     5521 aaaaaacttc tacgaaaatg agaaaaaata aggatagagg ttgtacattt gctttgttta
     5581 tgataaaatt aaatttatgt gtaaagttaa ggagagtata tgtataagtt attaacgaaa
     5641 gatggcatgg ccaaacgagg agagtttgag acagtccatg gtacgataca gactcctgtt
     5701 tttatgaatg taggaacagt aggagcaatc aaaggtgctg taagcacgga tgaccttcgt
     5761 acaatcggaa cgcaggtgga gctgtctaat acctatcatc ttcatgtaag aacaggtgat
     5821 aaactaatca aacagtttgg cgggcttcat aaatttatgg gatgggataa accaatcctt
     5881 accgattctg gcggatttca ggtgttttct ctgtcaggtc ttcgaaagat aaaggaagaa
     5941 ggcgtatatt tccagtcaca tattgatgga catcatattt ttatgggacc ggaagaaagt
     6001 atgcagattc agtctaatct tggttctacg attgcgatgg catttgatga atgtccttca
     6061 agtcgggcag acagaaccta cattcagaat tctgttgaca gaacaacaag atggttagaa
     6121 cgctgtaaaa aaaagatgca ggaattaaac agcctgccag ataccgtaaa tccacaccag
     6181 atgttatttg gtattaatca gggtggtgtt tttgcggata tccgtatcga gcacgctaaa
     6241 agaatcagtg agcttgattt agatggttat gcagttggcg gacttgcagt aggagagaca
     6301 catgatgaga tgtactatat ccttgatgaa gttgttccgt atctgccgga aaataaacca
     6361 acttacctta tgggtgtagg aaccccagca aatattattg aggcagttga cagaggaatc
     6421 gacttctttg actgtgtata tccttccaga aatggaagac acggacatgt gtatacgcat
     6481 catggaaagt taaatctttt taataagaag tttgaattag acccccgccc aatcgaggaa
     6541 ggatgccagt gtccgtcatg tcggacatac agcagagcct atatcagaca cctgctcaag
     6601 gcaaaagaga tgcttggaat gcgtctttgt gttcttcata acctgtattt ctataatcat
     6661 ttaatggaag aaatacgtgg agcaattgat gaacaccgct acaaagagtt caaaaaaacc
     6721 acattagaag gttttttgac accggaagaa gaataccggt aatatattat atagaagaat
     6781 aacggaggta aggacatgtt attagcacag agtgcgagcg caagctcatc tattacaatg
     6841 atcattgcat atgtcattct ttttggagcg attatctact ttatgacaat ccgtccacag
     6901 aagaagcagc agaaagcagc agacgagatg catgcaggaa tgcaggctgg agacagcgta
     6961 ttgactacaa gcggattcta tggcgtaatc atcgacatca tggatgacac tgtaatcgta
     7021 gaatttggta acaaccgtaa ctgcagaatc ccaatgcaga aagatgctat tgcagcagtg
     7081 gagaagccaa atcttacaaa gacagaagaa gagtagtttc ggttagcggg acagacgaaa
     7141 aatgaaaaag cagatatcct atatttgtga ctctatcact gcgggttgaa tgttcgcctc
     7201 cgggttcaca ttcaatcctc gctaaggcca caaatatagg atatctgttt tttgctaaat
     7261 tgaaagtact ctccagttta acaaagacag aaattaagag accgccaata tataaaaaat
     7321 gcgccttaga gcaagctctt aatgcggacg agcattaaga gcgcagtgat acgaagcatt
     7381 ttttatatat tggcggtctc ttaatttcgt ctcgcttgtt ctaaacagag aacccttttc
     7441 ataggctata aaaaagcctt tggtgcagcc tatggatgga atttcgtata aaaaatggat
     7501 ggagcgtgca gcaggcctgt ttctttctgc attaattgca gtattactca caatgctatt
     7561 tttagcagtg tttgcatttg ccatgttgaa aggtaatctt tccgcttccg tagaaaaaat
     7621 tggtttaatt gttatgagtg tgatggcttg ttttgtcggg ggatttttgt gtgggaaaaa
     7681 gaatatgaaa aaacggtatt tatgggggct tggcgtaggt gttttatatt gcttgttttt
     7741 tggagtaata cgcgtcggga tggggcaggc atttgtgaca gatacgacag cattttttac
     7801 aatgatgctt tattgtgcgg caggaggaat gcttggagga atgttaagct aaaaagttct
     7861 tttcttacgg gagggtttgt gttataataa cctacaaagt gtcatcttag atgctttaca
     7921 tactagatca tgaagtgagg aggcgttatt aatgaaacgt gtaaagacac tgaccggaaa
     7981 caaaacttac ggtactacaa tgtgtaaagg tggatgtggc gagtgccaga catcctgcca
     8041 gtctgcctgc aagacatctt gtacagtagg taaccagact tgcgagagta ataaataatt
     8101 agagagcaca acaggaagaa tgcttcctga tatatgcttg aagtagggtg aactgtcttt
     8161 tttgtcagtt caccttatct cttgtatgga aaagtatgtt tgcagagatt actttattgt
     8221 aagttgaaaa tattgtatac aggaatgttc tgtattatat atctatttta aagttagcag
     8281 gacatatctt caaattaaaa atatatttta gaaaattaag tataaaaact ataaaagaaa
     8341 tagaaaggga tatttaacgt gattcaccag tataaaaata atggatataa tattgtcatg
     8401 gatgtgtgca gtggtgccat tcatgttgtt gatgatgtaa cttatgatgt cattgcttta
     8461 tatgaagaaa aaagcttaga agaaatagaa aatgaacttt cttacagcaa ggaagatatt
     8521 gaggaagcat ataaagaggt aacttcttta aaagaagagg gacttttatt tacagaagat
     8581 atttacgaag attatattaa agaggtaaag agcagaaaga cagtagtaaa ggcactttgc
     8641 ctgcatattg cgcatgattg taatcttgcc tgccgctact gttttgcaga agaaggagag
     8701 tataaaggac accgtgaact tatgagtgca aaggttggaa aggctgccct tgatttcctt
     8761 gtagccaatt ctggaaaccg tcataatctt gaagttgact tctttggcgg tgagccaaca
     8821 atgaacttcg gtgttgtaaa ggaagttgta gaatatggac gttctcttga agaaaaacat
     8881 aacaaacatt tccgtttcac tttgacaacc aatggtgtgc tgttaaatga cgagattatg
     8941 gaatttgcca ataaagaaat ggacaacgtt gttttaagtg tcgatggacg taaagaaatc
     9001 catgattaca tgcgtcctac aagaaatggt aagccaagct atgaccttat catgccgaag
     9061 tttattcgtt ttgcagagtc cagacatcag cagaaatact atgtaagagg aacatttacc
     9121 aatagaaatc ttgatttctc caaagatgtt cttcatcttg cagacttagg atttgaacag
     9181 atttccatgg aaccagttgt tggacagcca gaagagccat acgcaattca ggaaaaagac
     9241 cttccacaga tttttgatga gtatgacaga cttgcaaaag aaatgattaa gagagaaaaa
     9301 gcaggaaaag gctttaattt cttccacttt atgattgacc ttacaggtgg tccatgtgta
     9361 gcaaaaagac tttccggctg tggaagcgga acagagtatt tagcagtaac accatgggga
     9421 gatttatatc cttgccacca gtttgtagga gaagagaaat tccttcttgg taacgttttt
     9481 gatggaatca agcgtaccga tatttgtgac gaattccgtt cctgcaacgt atacacaaag
     9541 aaaaaatgta aagactgttt tgcgagattc tactgtagcg gcggctgtcc tgcaaactct
     9601 tataatttcc atggaacaat tgatgattct tatgatttaa gttgcgatat ggagcgtaag
     9661 agagtagaat gcgcaattat gattaaggct gcattagcag atacagaagg cgaagaagaa
     9721 tagatggaaa agtggtttat cgcttcaaaa agagcagatt ttaataaaat tggtgagata
     9781 tttcatatca gcccggtaac ggcgcgtctg atgagaaata ggagcttaac aacagttaag
     9841 gaaatgcagc gttatcttta tggctctctg tctgatttat atgattctca tcttttgaaa
     9901 gatgccgata agggagcgga aatcataaaa gagaagatag aaacaggcaa aaaaattcgg
     9961 attatttcgg attatgatgt agatggtgtt tcatcaaact atattttata tcagggatta
    10021 aaacgctgtg gtgcggatgt tgattataag attcctgacc gtgtggaaga cggttatgga
    10081 attaatgaac atctgataga aaaggcagca ggggacggaa ttgatacgat tatcacctgt
    10141 gacaatggaa ttgcggcagc agaacagatt gcttatggaa attctttagg actcaccctg
    10201 attgtgacag atcatcatga tattccgttt caaaggcaag aagatggaag tatttcttat
    10261 aatttgccgt cagccgctgc cgttattaat ccgaagcaaa aagattgtcc gtatccattt
    10321 gaaaatatat gcggagcggt tgttgtctac aagtttattc aggtgcttta tgatttgttt
    10381 ggaattgacc gtagagaaag tgaagcattt cttgagattg cggcgatggc aacagtctgt
    10441 gacgttatgc cattgtgtga tgagaaccgt attatcgtaa aggaaggcct gcgacggata
    10501 cagcatacga atattaccgg gctgcaagct ttaattgagg caaatcatct tgaagaaaaa
    10561 aagatatctt cttatcactt tggatttatt ctcggtccgt gtattaatgc ttccggtcgt
    10621 ttgacctctg caaaagatgc gttagaactt cttctatgcg aagataaaga actttgcagg
    10681 cagaaagcag aagcactcac acagctaaat acagagcgaa aagaaatgac agctaacggg
    10741 gtaaaagctg caaaagaata tctcgaaagc accggacatg caaacgataa ggtacttgtt
    10801 gtatatcttc caaactgtca cgaaagtatc gccggaatta ttgccggaag aatgaaagaa
    10861 cattaccata agccagtatt tgtcatcaca agaacaaaag aaggattaaa aggctctggc
    10921 cgttctatcg aagcctatca tatgtataag gaaatgaaca aaatcaagga atgtttcgat
    10981 aaattcggtg ggcacccgat ggcagcagga ttttctatgc aggaagaccg cttagaagaa
    11041 ttccgggaaa aattaaatgc caacgcaacc cttaccgaag atgatttcgc agaaaaagtt
    11101 cacattgatg tagccttgcc gatatcttat ttatccgaaa gtctcatcaa tgaatttgaa
    11161 ttactagaac catttggaaa tgaaaacaca aaaccgctct ttgcacaaaa agacctttac
    11221 ataaaaggaa tgcgggtact cggaacaaca ggcagatgtt taaaactctt cctgtcggat
    11281 gccaatggaa caagcataga tgccatgtat tttggagaat ccgatgtatt tttagaagaa
    11341 ctcatctctt tttgtggaaa agaagaggca cagagaattc aaaaaggcct gtcacatcat
    11401 atatggatgg atgtgactta ttatccacag gtaaatgaat ggcgagggca gaagaatatc
    11461 caaatcgtca tccagaatta tcgttttaaa aatttatgag ataaattttt tagtgcttct
    11521 ttcgcatatt ttttcgtctg tttagattcc caattaataa aaaactatcc taatttgaca
    11581 aataaggcga gaatcaatag aataatatga ggatgaaaag agagatacat caaaatcgct
    11641 atgaattaag agatagataa ggagaaaata tggaacagga gaaaaaacag ccagatgtca
    11701 gattgatagg attagattta gatggaacaa cgctcacttc agataaggtg ttaactccac
    11761 atacaaagga agtacttgag aaatgtcttg cggaagggat tcaggtttta ccggcaacag
    11821 gaagagtaaa atcgggtatt ccagaatatt taacacagat tgaaggaatg agatatgtta
    11881 ttttatccaa tggtgcaagt gtattagatt taaaagagga taaagttctt tatcagaatt
    11941 gtattccgtg ggagagagca ttggagttat tcgatgtgtt agaaacatat gatacatttt
    12001 atgatattta tgcattagga gctggctggt gtgaggctcg cttttatgat aatgtagaaa
    12061 actatggaat tgagaaacat atcgagaagc tggttcgtac atcacgcaat cgtattgatg
    12121 atttaagaga gtggatgaaa gaaaataaag ctccagtgga gaagataaat atgttctttg
    12181 caaaggaaga agacagacag agagctttcc gtgaacttgg aaagatagaa gatttggcgg
    12241 ttacctgttc tcttggtaat aatcttgaga t
//
