LOCUS       c00022_gnlPro..        16169 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PJNHMONN_22.
ACCESSION   c00022_gnlPro..
VERSION     c00022_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 00:08:29
            Original ID  :: gnl|Prokka|PJNHMONN_22
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16169
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16169
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1196:6169]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1197..6169
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16169
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16169
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(2..88)
                     /locus_tag="ctg22_1"
                     /transl_table=11
                     /translation="MNNAVSYAMDSQVIFQMFFSIVCIAAAIG"
     CDS             547..936
                     /locus_tag="ctg22_2"
                     /transl_table=11
                     /translation="MKKLFYPAVFHIAEEGGYWVTFPDFPECLTQGENMQEAYDMAIDA
                     LGLILTDDINDHKELPEPSNITHVDDGVVVIIPYDYLEYNRKYHNKSIKKTLTIPEWLN
                     NEALRLNLNFSQILQDALLNKIQSR"
     CDS             complement(1197..2609)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_3"
                     /sec_met_domain="HMGL-like (E-value: 1.1e-43, bitscore:
                     139.8, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 5.2e-59, bitscore:
                     189.5, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDACLRFLKEDPWERLRKLRDGFKNTKLQMLFRGQNILGYKPYPDDVVE
                     YFVQKSIANGIDVIRIFDCLNDLRNLQTAVNATKKEGGHAQVALSYTIGDAYTLDYWKN
                     TAKNIEEMGADSLCIKDMAGLLVPNEATRLVTALKQATDIPIELHTHYTSGVGGMTYLK
                     AVEAGVDIIDTAISPFAMGTSQPATEVMAETFRGTEFDTGFDQKLLGEIADYFRPIREK
                     YLANGLMSPKVLGVNIKTLMYQVPGGMLSNLVSQLEQQGASDKFYEVLEEVPKVRKDFG
                     EPPLVTPSSQIVGTQAVLNVLTGERYKMITNESKALLRGEYGQTVKPMNKEVQKKAIGD
                     EKPITCRPADLLEPELSKIEAEMSQWKEQDEDVLTYALFPQVATEFFKYRAAQENKIDP
                     AKADVKNGAYPV"
     CDS             complement(2767..3891)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_4"
                     /sec_met_domain="OAD_beta (E-value: 1.5e-157, bitscore:
                     514.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVST
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGAEA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             complement(3925..4293)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.6; E-value:
                     4.3e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_5"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.2e-21, bitscore:
                     66.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEASAAPVSTPAAVPAPAKKAAP
                     KTSGSAGAVKITAPMPGKIVAVKAQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             complement(4388..4732)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_6"
                     /sec_met_domain="OAD_gamma (E-value: 7.7e-28, bitscore:
                     87.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSADKLV
                     VRSIKRVKRR"
     CDS             complement(4745..6169)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_7"
                     /sec_met_domain="CT_Vparvula (E-value: 7.4e-138, bitscore:
                     450.3, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNSKMNARERIDYLFDDHSFVEVGGYVSARNTDYNLGAKKVEGD
                     GVITGYGVINDRMVYVYSQDASALGGSVGEMHAKKIASLYDLAMKTGAPIIGMLDCAGL
                     RLQEATDALHAFGTIFNKQAQASGMIPQISAVFGMCGGGSAVMSAMSDFTLMEKENGSL
                     FINSPNALAGNEESRQNTAGAQFQSEQAGNVDFVCETEEALLDQLRILVDVLPSDYEAE
                     DVYFDNDDDLNRVIPELNDAAYDAAYILKSISDNNMYIETKAAYAKEMVTAFIRLNGET
                     VGAVANQPVDGESVLTRNGLEKAERFIKFCDAFSIPLLTVTNVTGLRANAHEERKQALA
                     LAKFTTTLAQVSVPRINLIAGEAYGTAAEVMNSKAIGADFVLAWPQASVGMMDAEQAVR
                     IMYAEEINTDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRKRLIAAYEM
                     LYGKKVTPVTKKHTAV"
     CDS             6893..7534
                     /locus_tag="ctg22_8"
                     /transl_table=11
                     /translation="MENRKIQFRSKACNLHLSAYPGHFATKHSHVNYFLDMTTLKVRQS
                     NAEEAARALVPLYKHNTVVDTIVCLDGTEVIGAFLAEKLTESGFFSYNQHKSIYIVTPE
                     IDSDGQMFFRKNIQPMIKDRNIIILMASVTTGITINRSWECIEYYGGKLQGISAIFSTL
                     SEYGNLPVNALFTPNDIPTYHTYDKHDCPYCKSGQKIDALVNGHGYSELL"
     CDS             complement(7668..8681)
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="MQKIPECRSMNFSIYEGMLNRYKDSEDIRKSYESRGLNGLEVIRA
                     GEPDEGKILPDMVNGVHLYFHIFWMDWWKGNYERLDQEFDSREQWLEYFGGMSRESYLN
                     SLRDDLAYAEQVGAKYVVFHVSEVTLRESYIYKYRYTDKEVIDASLEVINTLLDEKEYP
                     FDFLVENLWWSGLTLKNVRLTRRLIEGMHTQKKGIMLDTGHYMNTTTQLKTPEDAVAYL
                     NKMIDKYEKAQMLHWFKGMHLQLSLGGDYVRKQRKEWREHPIDFDKIPFYELFRLAYDH
                     ACHIDLHQPFIGEGVREFVERVAPKYITLEYQQNSREEYEQFVETQSKILKWITIH"
     CDS             complement(8818..9792)
                     /locus_tag="ctg22_10"
                     /transl_table=11
                     /translation="MADWKSSQEFLKEFYASPIVNEDTISAKIKRIFLPKSRKASALKE
                     LAGDLSGEGRAGDVILDNDMFEMDTEIWKKQEKRRLSVRTRVSLFLLLVAIPLTIAVGF
                     YVMDVAAVGTVFEKIFGPRKYYFISLVIIIYSLLPFFMVFEGRKPQVRELVVLATMVAL
                     ATAGRAAFFMIPSFKPIIAIVIISAIAFGGEAGFLVGAMTMVVSNFLFGQGPWTPWQMF
                     AMGFIGFLSGILYRIGLLPTKRLSLCIYGFLVTVFIYGGIMNPAALFMSVYDFTWEGLL
                     AIYISGIPVDLVHASSTFIFLWIGAKPLLEKLQRIKIKYDLMR"
     CDS             complement(9796..11589)
                     /locus_tag="ctg22_11"
                     /transl_table=11
                     /translation="VTANGLSEKKNSILEINDLCFAYPEEKKRALNHVSLHVEDGEFLV
                     LCGKSGCGKSTLLTHLKTPLTPHGKRKGEILFQGVPIGEMSNREQSQRIGYVLQNPDNQ
                     IVTDKVWHELAFGLESLGYSNADIRIRVAEMASYFGIQDWFYKNVSELSGGQKQLLNLA
                     SIMAMHPDMLILDEPTSQLDPIAASDFLETVKKINRDLGTTIILTEHRLEEVFPSADRV
                     VVMDEGQILCVGTPPEIGEELKKRNHEMFLAMPVPMQVYAKVESEQPCPITVRDGRKWL
                     DIVCKKKGISPANASSSYRKESDSQKGKSSFSKITEKFTEKFKEKKEDIILACDDLWFR
                     YDKELPDVVKGLSFSLKRGEFFALLGGNGTGKTTTLSLLSRLRKPYRGKVLLEGKDIRR
                     YSNKELFRNFLGVLPQNPQSLFVKKSVELELFEMVGGVKEKKDEEYQLAMDKKDAVEGI
                     IKVTHLEELLHRHPYDLSGGEQQRLALAKILLLRPKLLLMDEPTKGLDSYFKKEFAGIL
                     ALLKEQGVTVFMISHDIEFCASYADRCGLFFDGNIVACGTPGEFFAGNNFYTTAANRMA
                     RRYFPMAVTGEDVVECLKKGV"
     CDS             complement(11631..12506)
                     /locus_tag="ctg22_12"
                     /transl_table=11
                     /translation="VTMFVVHPVILAISFICAVAYSVVLKGWKKTVKFNLLFSLPMMII
                     VALINPMFNHYGVTIIGYLHNGNPFTLESCVYGLVMAVMLVCTLVWFSCYTVVMTSDKF
                     IYLFGRIIPALSLVLSMCLRFVPKFIKEASVISDGQKCVGRSVENGSLIKRAKHGITIF
                     SILVTWSLENAIETSDSMKCRGYGEKGRTAFSLYHFDKRDFLCLIFMIITFGAAMWGFS
                     KGYAFCSYNPRIVVKGVPFTAGSLLVFAAFLLFSIMPAAMEILDRRMWKARRGQVESAA
                     PAGYRLWEVE"
     CDS             complement(12649..13830)
                     /locus_tag="ctg22_13"
                     /transl_table=11
                     /translation="MNEIPEDGIITKEQFKTVAGDNKKVQFKGTTDDGITYIWTYDCSK
                     IQNPADQNLKIDFSEKGLDDLKKQANNANDALKMTMYGKGLICVPDLEVQLPEAWQSNS
                     AYLVKEQAGKLARMSDVVVTAQAEEDSSKKKDTSASQKDSSDKVKEATTAAKKDTKPQK
                     GTTSLKMSVTSLDGDCYIIGGITEQQNKGASAANKAENGTTNSESEGSDESGNSGENSY
                     NEEGSSGSGDVSDGGASSSGSSGKQDVANDEEVSGSSHTCTISISCATILNNMSDLKSG
                     KEEFVPSDGWILAASEVEFTEGESVHDVLQRVCKDAGIQMESSFTPAYNSAYVEGINNL
                     YEFDCGQLSGWMYNVNGWFPNYGCSKYTVQDGDVINWVYTCNLGKDVGDNSMY"
ORIGIN
        1 cacctatagc tgccgctata catacaattg aaaaaaacat ctgaaaaatc acctgactat
       61 ccatagcata tgaaactgcg ttattcattg tatctccccc tgactatctt ttgatacttc
      121 attttaccat atctctgtat ttttatcaaa aatttttcat tttcaaaatt acatttttta
      181 tgttatttta catttattag ttgtttttct tcttaaatat gatatactat tcctcaccag
      241 ttgtatcacc gagttcttga cacacgtata ttatacgtat tataatataa ttatagaaag
      301 gggtggcata ctatgccaat gaaaccaaaa gaaatgataa gattattaaa aaagaatggt
      361 ttcataaaaa taagtcaaaa tggttcccat gtgaaaatga agaattttaa aactggcaaa
      421 caaacaacag ttcctcttca tagcaaagat ttaaaaaaag gactagaaga tgccatccta
      481 aaacaagcgg gcttaaaata gccttatttc atctataata actcacatac attggaggta
      541 tccattatga aaaaattatt ttatcctgct gtatttcata ttgcagaaga aggcggttat
      601 tgggtgactt ttcctgactt tcccgaatgt ctaactcagg gagaaaatat gcaagaagcc
      661 tatgatatgg ctatagatgc tttaggactt atcttaactg atgacattaa cgaccataaa
      721 gaacttccag aaccgtctaa catcacacat gttgatgatg gagttgtcgt aatcatccca
      781 tatgattatt tggaatataa tcgaaagtat cataataaat ctatcaaaaa aactttaaca
      841 atccctgaat ggttgaataa cgaagcattg cgattgaatt taaacttttc acagattttg
      901 caggatgctc ttttaaacaa aattcaatct cgttaatggc tataattctt tcatttggta
      961 atactgcaat catagattat aatatactta acaaggcagc taatacgata gcttcaccta
     1021 tccatttccg gcaagtttag gttaaaaaac agaaccccca caactttata gatagcaaat
     1081 gtgatgtcgg agcaagtaaa aatgcggctg agcattttct acgcagcgaa atcttcacat
     1141 gtgctatcta taaagttgcg ggggttcgtc tgtttttaat ctaaatcaat ccaatcctac
     1201 accggatatg ctccattctt tacatcggct tttgcaggat caatcttatt ctcctgtgcc
     1261 gctctgtatt taaagaattc ggttgctacc tgtgggaaca atgcgtatgt aagcacatct
     1321 tcgtcctgtt ctttccactg gctcatctct gcctcgatct tagataattc cggttcaaga
     1381 aggtcggctg gacgacaggt aattggcttt tcatcgccga ttgccttttt ctgtacttct
     1441 ttattcattg gttttacggt ctggccgtat tctccacgaa gaagggcttt tgactcgttt
     1501 gtaatcattt tataacgctc tccggtaagt acatttaata cagcctgcgt tccgacaatc
     1561 tgactggacg gtgtaactaa tggtggttca ccgaaatctt tacgtacctt tggcacttcc
     1621 tctaatacct catagaactt atcagatgcg ccctgctgct ctaactgaga tacgaggttg
     1681 gaaagcattc ctcccggtac ctgatacatt aacgtcttga tatttacgcc aagtaccttt
     1741 ggactcatta aaccatttgc cagatatttc tcacgtattg ggcggaaata gtctgcaatc
     1801 tcgcctaaaa gcttctggtc aaatcctgta tcaaattctg taccgcggaa tgtttcagcc
     1861 ataacttctg ttgccggctg gcttgttccc attgcaaatg gagatatggc tgtatcaatg
     1921 atatcgactc ctgcttctac tgcttttaag taagtcattc caccgacacc acttgtatag
     1981 tgtgtatgaa gttcgatagg aatgtctgtt gcctgcttta atgcagttac aaggcgagtt
     2041 gcttcattcg gcactaaaag acctgccata tctttgatac aaagggaatc tgcacccatt
     2101 tcttcgatat ttttcgctgt atttttccag taatctaatg tataggcatc accaattgta
     2161 taagaaaggg caacctgcgc atgtcctccc tctttctttg ttgcatttac cgctgtctgt
     2221 aagtttctaa ggtcatttaa acagtcaaag atacgaatga catcaattcc gtttgcgata
     2281 gacttctgta cgaaatattc tacaacatca tccggatatg gcttatatcc taaaatgttc
     2341 tgtccgcgga ataacatctg taactttgta tttttgaagc cgtctcttaa tttacgaagt
     2401 ctctcccatg ggtcttcctt taagaaacgc aggcaggcat caaatgttgc gcctccccag
     2461 cattctactg catgataacc aacctgatcc atcttatcta cgattggcag catctcctct
     2521 gttgtcattc ttgtagcaat cagagactga tgtgcgtcac ggagaacagt ttcaacgatt
     2581 ttaactggtt ttttcttaat ttcggccata atatctcctt ttatttcaaa tcacgtaact
     2641 atttgcgctt acaactgtta ttatctaaaa ttcaacttgt aaactattta taaatatccc
     2701 ctgtaacatt ttttacagat tatagcccta taaataatga attttaaata atcaaataat
     2761 tctaaattat actccaaaaa ttgccataaa tgttccggct gctactgcag taccgataac
     2821 tccggcaacg tttggtccca tcgcatgcat cagtaagaag tttgatggat ctgcttccgc
     2881 accaactttc tgggatacac gggctgccat aggaacggca gataccccag cagaaccaat
     2941 taatggattt accttaccac ctgtaacctt acacataagt ttaccaaaca ggacacctgc
     3001 tgcagtacca acagcaaaag ctacaagacc taatactaca atcttgattg tgctgacatt
     3061 taagaatgcc tctgcacttg ttgtcgcacc aacggatgta ccaagaataa taactacgat
     3121 gtacataaga gcgttagacg ctgtctctga aagctgtttt actacaccag attctctgaa
     3181 aagattaccg agcatcagca taccaactaa tggcgctgtt gtaggaagaa tcaaacatac
     3241 aacaactgtt acgacaatcg gaaacataat tttctctgtt tttgtaacgg ttcttaactg
     3301 ttccatctta atctgacgtt ccttttctgt agtaaggagc ttcatgatcg gtggctgaat
     3361 aattggtaca agtgacatat aagaatatgc cgctaccgca attggtccca ttaagtctgt
     3421 ctgcccaagc tttccggcaa ggaaaataga agtaggacca tcggctccac caataatgga
     3481 aattgctgct gctgcctttc cgttaaatcc cataagcatt gcaaggaaat acgcactgta
     3541 aataccaaac tgcgccgcag ctcccagcaa gaaacttgct ggattggcaa tcagcggacc
     3601 gaagtctgtt agtgctccaa cacctaagaa aatcagtgaa gggagaatac tccattcatc
     3661 taataagtaa aaataatgta ataatccgcc ttcttccata atggacggat ataagttaac
     3721 cagcagcata ccaaaagaaa tcggcactaa caaaagtggc tcatatcctt tggcgatggc
     3781 cagatataag aagactaaag caaccagtat cataatgaag ttacctggct ttaagaatgc
     3841 aaatccggtc tgtgctgcga gattcgtcat tgtctctaca acataactca taaatcttcc
     3901 tccgttttat tttgcaaata tgctctagtt cattgtagcc agtacatctc cgccttctac
     3961 catatctcca actgctactt ccacacttgc gataacacca tcctgtgctg cacagatttc
     4021 attctccatc ttcatagcct ctaatacaag aacagcgtcg cccttcttta cagaagcacc
     4081 tgcctgtgcc tttactgcta cgatcttacc tggcattggt gctgtaatct ttacggcacc
     4141 ggcacttccg gaagtctttg gggcagcttt cttagctgga gccggaacgg ctgctggtgt
     4201 acttaccggc gctgcacttg cttctcctgc acctaattct tctactgcta catcataagc
     4261 aacaccatta actgtaattc tataattttt cattgtaaat cctcctgaat gattttatgt
     4321 acttctaaaa tctttctata gctaactttt caaaacttta taaaaagatt ccaagaatac
     4381 atttttgcta tcttctcttc actctcttga ttgaacgaac gaccaactta tctgcactga
     4441 ctgctgctcc tccattcgct gccatgattg ccgctgtgat tactgcgaca agttcaccat
     4501 catccacaag ttcctcttct tccacaactt cttcaagaat cggacgcttt ggagccggtc
     4561 tttcttcctg cgcagccttt ttctctttct tagaagaacg attctttaac gctctttcaa
     4621 tagatgggat atatacaaaa agagaaatca ataaagaaat gaaaatcagt actgcaaata
     4681 cagttcccat acccatcaaa gtatttaata aggcttgttc aaatacgttc atactctcac
     4741 ctcactatac tgccgtatgc ttctttgtca ctggagttac tttctttccg taaagcattt
     4801 cataagcagc gataagacgc tttcttgttg cgtccggctc gatgatgtca tctatatatc
     4861 ctctctttgc agctgctaat gcactgctct gtccttctgc atattccgca gttttctctg
     4921 cgataagtgc tgtcttattc ttatctgtat tgatttcctc tgcatacatg atacgaactg
     4981 cctgttctgc atccatcatt cctacagatg cctgtggcca tgccagaaca aagtcagctc
     5041 cgatagcttt agaattcatt acttccgctg cagttccata agcctcgcct gcaatgagat
     5101 taatacgagg tacactaacc tgtgcaagtg ttgtcgtaaa cttcgctaat gcgagcgcct
     5161 gctttctctc ttcatgtgcg ttggcacgaa gtcctgtcac gttcgttaca gtaagaagag
     5221 gaatcgaaaa tgcatcacag aacttaataa atctttctgc tttttcaaga ccatttcttg
     5281 ttaaaacgga ctcaccatct actggctggt ttgcaaccgc acctactgtc tctccattca
     5341 gacggataaa tgcagttacc atctctttgg cataggctgc ctttgtctct atgtacatat
     5401 tgttgtcaga aatagatttt aaaatgtaag cggcatcata tgcggcatca tttaactcag
     5461 gaataaccct atttaaatca tcatcgttat caaagtaaac atcttctgct tcataatcag
     5521 aaggaagtac atcaacgaga atacgaagct ggtcaagaag tgcttcttct gtctcacata
     5581 caaaatctac gttaccagcc tgctcagact ggaactgtgc tcctgccgta ttctgacggg
     5641 attcttcatt ccccgctaat gcattcggac tgttgataaa gagactgccg ttctccttct
     5701 ccatcaatgt aaaatcagac atagcggaca ttacggcact tcctcctcca cacattccaa
     5761 atactgcaga aatctgtgga atcattccag atgcctgtgc ctgcttatta aaaatcgttc
     5821 caaaagcgtg aagggcatct gtcgcttcct gtaatctaag tcctgcacaa tccagcattc
     5881 caatgattgg cgcgcctgtt ttcatcgcca gatcataaag ggaagcaatt ttcttcgcat
     5941 gcatctcacc tacggaacct ccaagtgcgg aagcatcctg actgtaaaca taaaccatgc
     6001 ggtcattaat aactccgtat ccagtgataa caccatcacc ttctactttc tttgcaccga
     6061 gattataatc ggtattacga gcggaaacat atccaccaac ttccacaaaa ctgtggtcat
     6121 caaacagata atcaatgcgc tctctggcat tcatttttga attacccata ttctttcctc
     6181 cataaaaatg ctatattgta taccttgttg ctctttcatt ctatgtaata ataacaaatt
     6241 attatcatgt tagcaaccat tttctgttag ttatttaaca tttattttat tttgcccatt
     6301 ccactaaaca aaatgaacat tctgcctatt tgcaaatttt ttaacaattc tttcaatttt
     6361 ctttctgaat ctcctgtttt tttcaggaac gcttgtgtat ttttcctgtt tttctctatt
     6421 ttatctttaa aattctattt ttgttttata tgtccatttt tatttcgtta taattttaac
     6481 gtattttgac attcaattac tagttggttt ttctattttt ttcgtcattt tatacaaaat
     6541 attctcattc tatcaaatat cttccgtttt tcttcataat ttcactctta tttccatcat
     6601 tcttcttttc tcgcttatat tctcctcctg tcttttttaa atcaaagata tagtatccaa
     6661 aatcaatttt gaactatttt tgtcaaactt ttttcacaaa ctaatagcgc tccctttcat
     6721 tttatacaac tgtatatgca taccatgaag tattttcaaa aaatcagaaa gaaattataa
     6781 actgtcaaga aaagcctgta attttgcaca aatactcctt tattttttca cacaaaaaag
     6841 gtataataaa caaaataaac aattctttca caataaagga ggaggacatc ttatggaaaa
     6901 ccgcaaaatt caatttcgtt caaaagcctg taatctacat ctttctgcct atccgggaca
     6961 tttcgcaaca aagcattctc atgtcaacta ctttttagat atgacaacat taaaagtacg
     7021 tcagtctaat gcagaagaag ctgcaagagc gttagttcca ctttataaac ataataccgt
     7081 cgtcgatacc atcgtatgtc ttgacggaac agaagtaatc ggtgcatttt tagcagaaaa
     7141 gcttacagag agcggattct tctcttacaa ccagcataaa tctatctata ttgttactcc
     7201 agaaatagat tcagatggtc agatgttctt ccgcaaaaac atccagccaa tgattaaaga
     7261 tagaaatatc attattttaa tggcatctgt cacaactgga atcacaatca accgaagctg
     7321 ggaatgtatc gagtactatg gtggcaaact gcagggaatt tcagcaatat ttagtacgct
     7381 ttctgaatat ggtaatcttc ctgttaatgc gctgtttact ccaaatgata ttcctactta
     7441 ccatacatat gataagcatg actgcccata ttgtaagagt ggtcagaaaa tcgatgcttt
     7501 ggtaaacgga catggatatt ccgaattact ataactacta atttgtagat ttcgtataga
     7561 cgaaaaaaag aaaccatacc atatcccaga tgcggatgag cattttaaac acaacgacta
     7621 cagagcagat gggatatggt atggtttctt ttttcgtctg ttttctctta atgaatcgta
     7681 atccatttca aaattttact ttgggtttct acgaattgtt catattcttc ccggctgttt
     7741 tgctgatatt ccagcgtgat atactttggt gctacgcgct ctacaaattc ccggacacct
     7801 tctccgataa aaggctgatg cagatcaata tgacaggcat ggtcatatgc aaggcgaaat
     7861 agttcataaa atggaatctt atcaaagtct atcggatgtt ctctccattc ttttcgctgc
     7921 tttcttacat aatcccctcc cagtgacaac tgcaggtgca ttcctttgaa ccagtggagc
     7981 atctgtgctt tttcgtattt gtctatcatt ttattcagat atgctacggc atcttccgga
     8041 gtctttagct gtgttgttgt attcatataa tgcccggtat cgagcatgat tccctttttt
     8101 tgtgtatgca ttccttctat aagccggcgg gtaaggcgga catttttcaa ggtaagcccg
     8161 ctccaccaga gattctctac aagaaagtcg aatggatatt ctttttcatc aagtagggta
     8221 ttgatgacct ctaagcttgc atcaatcact tctttatctg tatagcggta tttataaata
     8281 tagctctccc ggagtgtcac ttctgaaaca tggaaaacta catactttgc tccaacttgt
     8341 tctgcatagg caagatcgtc ccgcaaactg ttcagataag attccctgct cattcctcca
     8401 aagtattcca gccactgctc tcttgaatca aattcctgat ctaggcgttc ataattcccc
     8461 ttccaccagt ccatccagaa aatatgaaaa tacagatgta ccccattcac catatccggc
     8521 agaatctttc cttcatctgg ctcgcctgcc cgaatcactt ccagtccatt taatcctcgt
     8581 gactcataag actttctaat atcttcacta tctttataac gatttagcat cccttcataa
     8641 attgaaaaat tcatggaacg acattctggt attttctgca tagtttcccc cttcaatctc
     8701 gtatactctc agaatctttc taagaataca ttttatctat acttatcatc catacttatt
     8761 tcaaaaatgc cccatcattc tggcaatctt tctaaagttc aaaaacgccc cggctattca
     8821 tctcatcaga tcatatttta tttttatccg ctgcagcttt tccaacaatg gctttgctcc
     8881 aatccacaga aaaataaatg tagaactggc atgaacaaga tctaccggaa tacctgaaat
     8941 atagattgca agcagtcctt cccatgtaaa atcatacaca ctcataaaga gagccgctgg
     9001 attcatgatt cctccataaa tgaacaccgt cacaaggaat ccatatatac aaaggctgag
     9061 ccgtttggtc ggaagcagtc ctattcggta aaggattcct gacaaaaatc cgataaaacc
     9121 catcgcaaac atctgccatg gggtccatgg tccctgccca aataagaaat tgctgactac
     9181 catcgtcatg gcaccaacta agaatcctgc ctcgccgcca aatgcgattg cactgatgat
     9241 cacgattgct ataatcggct taaagctcgg tatcataaaa aatgctgccc ggccggcggt
     9301 tgccaatgct accattgttg caagaacaac tagctctctc acctgaggtt ttcgtccctc
     9361 aaataccata aaaaacggta ataacgagta tataatgatt accaggctaa taaaataata
     9421 ctttcttgga ccaaaaatct tttcaaatac tgtgccaaca gcggcaacat ccataacata
     9481 aaatccgaca gcaattgtga ggggaatcgc tacaagcaag agaaagagac ttactctggt
     9541 acgaacagaa agcctgcgtt tttcctgctt tttccagatt tcggtatcca tctcaaacat
     9601 atcattatct aaaatgacat ctcccgccct gccttctcct gacaaatctc ctgctaattc
     9661 ttttaaagca gaagctttcc tgctttttgg taaaaagata cgctttatct ttgcagaaat
     9721 cgtatcttca ttcacgattg gagaagcgta aaattctttc aagaactcct gacttgattt
     9781 ccagtctgcc attgttcaca ctcctttttt aagacattcc acaacgtcct ccccggtaac
     9841 cgccatggga aaataccttc tagccattcg gtttgccgct gttgtataaa aattatttcc
     9901 ggcaaagaat tctcccggag ttccacatgc cacaatattt ccatcaaaaa ataaaccaca
     9961 tcggtctgca taagaagcgc agaactcaat atcatgagaa atcataaaaa cagttacgcc
    10021 ctgctctttg agtaatgcca gtattccggc aaattctttt ttaaaatagc tgtccagtcc
    10081 tttggtcggt tcatccatca acaaaagctt tggccgcaat aacaaaatct tagccagggc
    10141 aagcctctgc tgctctcccc cgcttaagtc atacggatga cgatgcagta attcttccaa
    10201 atgtgttact ttaatgattc cttccaccgc atccttttta tccatggcaa gctgatattc
    10261 ttcatccttt ttctctttta caccgcctac catttcaaac agttctaatt ccacactttt
    10321 ctttacaaaa agagactgcg ggttttgcgg cagtactcca agaaaattgc ggaatagttc
    10381 tttattgctg taacgacgga tatccttacc ttctaaaagt acttttccac gatatggctt
    10441 tctcaaacgg ctcaaaagtg aaagtgttgt tgtcttcccg gttccatttc ctccaagcaa
    10501 tgcaaagaat tctcctcttt ttaaggaaaa gcttagtccc tttacgacat ccggcagttc
    10561 tttatcatag cggaaccaca gatcatcaca cgctaagatg atatcttctt ttttctcttt
    10621 aaacttttct gtaaactttt ctgtaatctt agaaaaagaa gattttcctt tttgggaatc
    10681 actctctttt ctatatgaag aagatgcatt tgctggtgaa atgccttttt tcttacaaac
    10741 tatatccagc cactttcgcc cgtcacgaac agtaatcggg cagggctgct ctgactctac
    10801 tttggcataa acctgcatcg gtaccggcat agctaaaaac atctcatgat tgcgcttctt
    10861 taattcttct ccgatttccg gcggtgtgcc aacacataaa atctgccctt catccatgac
    10921 cactaccctg tcagcagaag gaaatacttc ctctaaacga tgttccgtaa gaataattgt
    10981 cgttccaaga tcacgattaa tcttctttac tgtttccaaa aaatcagaag ctgcaatcgg
    11041 atcaagctga gaggtcggct catcaagaat cagcatatcc ggatgcatgg ccatgataga
    11101 tgccagattc aaaagctgtt tctgtcctcc agaaagttcc gatacatttt tataaaacca
    11161 gtcctgaatc ccaaaataac ttgccatttc cgctacccgg atacggatat ctgcgttact
    11221 gtatccaagg ctttccaaac caaatgccag ctcatgccac actttatctg tcacaatctg
    11281 attatccgga ttctgtaata catagccaat cctctgactc tgctcccggt tactcatctc
    11341 cccgattggt actccctgaa aaagaatctc tccttttcgc tttccatgcg gcgttagggg
    11401 agtctttaaa tgtgtcagaa gtgtactctt tccacatcca ctctttccgc aaagaacaag
    11461 gaattccccg tcctccacat gcaaagaaac atgatttagc gccctctttt tttcttctgg
    11521 ataagcaaaa cacaaatcat tgatttctaa tatactattt ttcttttctg acaaaccatt
    11581 cgctgtcacc ctgcacctcc aaacttgctt tttatctcct gtatatacgg ctattcaact
    11641 tcccacaaac ggtacccagc cggtgctgca ctttctacct gtcctcttct cgccttccac
    11701 atccttcggt ctaaaatctc catcgctgct ggcatgatac taaacaataa aaaagcggca
    11761 aagacaagca ggctgcctgc tgtaaagggt actcccttta caacgatccg aggattataa
    11821 gaacaaaatg catacccctt tgaaaagccc cacatcgctg ctccgaatgt aatgatcata
    11881 aaaataaggc acaaaaaatc ccttttatcg aaatgatata aggaaaaggc ggttctgccc
    11941 ttctctccat atccccggca cttcattgaa tccgatgttt caatcgcatt ctccaaagac
    12001 caggtaacca gaatcgaaaa aattgtaatt ccatgctttg ctctcttaat aaggctccca
    12061 ttctctacac ttcgcccgac acacttttgc ccatcagaaa taacagatgc ttctttgata
    12121 aacttcggta caaagcgaag gcacatggaa agtactaaag aaagtgccgg gatgatcctt
    12181 ccaaaaagat aaataaactt atctgatgtc ataacaactg tgtagcagga aaaccataca
    12241 agagtacata ccagcatcac tgccatcaca agaccgtaca cacaactttc taatgtaaac
    12301 ggatttccat tatgaagata tcctataatc gttactccat aatgattaaa catcggattg
    12361 atcagggcaa caataatcat catcggtaat gagaagagca gattaaactt tactgtcttt
    12421 ttccatcctt ttaaaacaac ggaatacgca acagcgcata taaatgaaat tgccagaatc
    12481 acaggatgaa caacaaacat cgtcaccccg attgtcccgc aaaaatacag catatttaaa
    12541 acaggatgat atgtcgaaaa tgtatctttc atctaaatca aatctccatt acattaaatc
    12601 tttattatat caagtcttta ttatatcaaa tctctatttc atacatcctt aatacatcga
    12661 attatctcca acatccttac caagattaca tgtataaacc cagttgatca catcaccgtc
    12721 ctgtaccgta tacttactgc atccgtagtt aggaaaccag ccatttacgt tatacatcca
    12781 tccggaaagc tgtccgcagt cgaattcata cagattatta attccttcca cataagctga
    12841 attataagcc ggcgtaaaag aagactccat ctggattcct gcatccttac atacacgctg
    12901 taatacgtca tgtacagact ctccttccgt aaattctacc tcggaagctg ccagaatcca
    12961 tccatcagaa ggaacaaatt cttccttgcc actttttaaa tcactcatgt tattaagaat
    13021 cgtcgcgcag ctgattgaaa tcgtacacgt atgggaagaa cctgaaactt cttcatcatt
    13081 tgcaacatcc tgcttgccgg aagaaccaga agaagaagct cctccatcag aaacatctcc
    13141 acttcctgaa cttccttctt cgttataaga attctctcct gaattccccg attcatcact
    13201 tccttccgat tcactgttcg ttgttccgtt ttctgcctta ttcgctgcgc ttgctccttt
    13261 attttgctgt tctgtaatac ctccaataat ataacaatct ccgtccagag aagttacgct
    13321 catttttaaa gaagtggttc ctttctgtgg ctttgtatcc tttttggcag cagtcgttgc
    13381 ttccttcacc ttatcagacg aatccttctg tgatgcagat gtatcctttt tcttggaaga
    13441 atcctcttct gcctgtgctg ttaccacaac atcgctcatc cttgcaagct ttccagcctg
    13501 ttcctttaca agataagcag aattcgactg ccacgcttcc ggaagctgta cctcaagatc
    13561 cggtacacag atcagccctt tcccgtacat tgtcatcttc aatgcatcat ttgcattgtt
    13621 tgcctgcttc tttaaatcat caagaccttt ctctgaaaaa tcaatcttca aattctgatc
    13681 tgctggattc tgaatctttg aacagtcata cgtccagata tatgtaattc catcatctgt
    13741 tgtcccttta aactgtacct ttttattgtc tcctgcaacg gtcttaaact gttccttcgt
    13801 aataattcca tcctccggaa tctcattcat atccgcaagt gttgctgtct tgccggactt
    13861 tttaccggaa gaacttcctc cattaccgga ctttccacaa ccggttgaaa caatcaataa
    13921 catactcata agcagtgcca gaacgacacg cataaatccc tttttcttca taaatacttt
    13981 ttccctttct ttgtatatcc ttagctttaa ctctgctcac tatacacctt atttttcttt
    14041 aaaaaacaga ttatcttttt aatctattcc ttatctccgc ctttttgaaa attgcgtaat
    14101 gcacttgcaa tcctatgacg ctttttatat aaaatgaaag caataatcac taccactgca
    14161 atagcgcaaa tccttttgac tatataaaat atccctaaac cagccacaat ctttgaggta
    14221 tcattatcct tttcggctgt ggtgtccgct tccgctgcat ctgtctcatc cgccgcataa
    14281 gtatccggta cgtaatcctc tccgctaaag ttccagcttc ctgtcgttgc ctctactgcc
    14341 gtatctttct tcttcgctgt cgttcctgtt gcactctttg acgcagtact tcccgtacct
    14401 gtaccggaag tgcttccgga agaaagtgtc tttgtcgttc ccgaagcagt tggtgttcca
    14461 cttcctgtac ttactgaacg attcgttgtt cccgatgtcg gtgttgtaat tctttttgtc
    14521 tgacttcttg ctgctgtagt tgttgttgtc tttttggcgg ttgtcgctgt tgccggtgca
    14581 gtcaccacga ccttacaggt tgctttcttt ccacttccgt cctttgcctt tactgtaatt
    14641 gtcgctgttc ctgccttctt tccagttacc tttccctttg catttactgt tgcaatcttt
    14701 ttattggaag aagaccattt cactgacttc ttcgtggcat ttgacggaga aaccgtcgct
    14761 tttaacgtct tactctttcc ttttgtaaga taaatcgtac tataatttaa tcccactttt
    14821 attaccttta ctttagaagc tgccggtttt gtttctgtct tttttgctgt cgttgaagaa
    14881 gaatttcctc cactattact ccccgtatca atcgtcggac tgactaccgg cttcgttcct
    14941 gccgaaatag ccacatcact catatcataa agaaatgtct ctccatccaa aaatctacgg
    15001 taagcaactg ttgcatacaa tccctgttcc gttgccattc catcgataat gccaccggca
    15061 ccgccaccat tattcccggc atcagcagct acatgcataa atcccccttc tggcatataa
    15121 tactggaata atcctgtcat cggccatttc ccattcttaa taaaacggac atcttcccca
    15181 caatctattc ccacgccaca aagagctgtg ataatctgtg ccacactttc cgaagtttct
    15241 gtattcatcg tgccaaaacc accactggaa agctgattct tttctatcca tgcaagtccc
    15301 ttgtcaattg ccgctgtaac atcctcatat ccatctttat tataataaga agccagcgcc
    15361 tgcatcgcca ttcctgtcat atcggaatct ccagttgttc ccatcaatgt ccagccacca
    15421 tcctgacact gcatccctac aaccttctta acaagtaact cctctgagtt ttgctgcact
    15481 gcagaagggt cttctggaat ctcatatgcc ggattactct ttaatgcaat caacgcccaa
    15541 atcgtgccat tattcccctg tctgcttaca ttctcataat ctgacagata cgctaacaga
    15601 ttatgtccca tcacatttct tgcatcgaca ccaatcgctg ttaatgcaag aataagcttt
    15661 gaataatccg aatactttgc tcttgtaatc tgccagtcct tactctcaca gtatgcgatc
    15721 acattactat aaaaaagatt tatataagat tccggcacat acagcccact cctttttaaa
    15781 ccaataacat tccatatgct actgtaatcc ggcttcgtat ctttacttaa gatatagctt
    15841 cttaccttag ataaaaccgt atcaatatcc ggacttaaga cttccgcctc tgcttccgtc
    15901 tgcactgcca ctcctgattc atcagactgt ccctgtgccg catcttcctc tgcaccccaa
    15961 gcataaaaac cataacttct tccaagctgc aaattcttac ggacaatctt tctctctttt
    16021 tttgttaatg tctgctcttg tgtactttcc tgtacatctg cctctgtact tgctgatgca
    16081 tctgcatctt ccctggtctg ctgctcctcc tcttccgaag actccgtctc ctccctttct
    16141 gatgtctcac tttctgacgt ctcactttc
//
