LOCUS       c00028_gnlPro..        14347 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GHDGKICM_28.
ACCESSION   c00028_gnlPro..
VERSION     c00028_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 02:47:14
            Original ID  :: gnl|Prokka|GHDGKICM_28
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 13532
            Orig. end    :: 27879
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14347
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[23532:27771](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14239
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14347
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14347
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(18..2069)
                     /locus_tag="ctg28_17"
                     /transl_table=11
                     /translation="MMHVEEGESQLGIPVREIKGIGEKTEKLLAKLAIETVDQLVHHYP
                     RCYTTYPEPISISEIKTGQRCSIEAEIASPIHLKTVRKLKLCTGLIADVSGQLFVRWFN
                     MPYLRNTLKQGERWIFTGTPIYKDGRLMLEQPEYCKREKYLQLMETFQPIYPLTTGLSN
                     KTVQKAQAAAFEMYREEEYLPETVRNYYDLEPVNTALREVHFPTGTEHLMEAKKRIIFD
                     EFFRFFSALELVKDREEQALNHYIIPMEEPVKRFVENLPYPLTGAQKKVLNEIRQDFSD
                     TMAMNRLLQGDVGSGKTIVAMTAMYAAVLAGYQAALMAPTEVLAEQHYQNFVKLLSPLG
                     ITVALLTGSTKAKEKREIKAACASGEIQILIGTHAVIQDDVAFDNLAFIVTDEQHRFGV
                     KQRDAFMKKGKDPHVLVMSATPIPRTLGIILYRDLDVSIMNEMPASRLPIKNSVVGTSY
                     RPAAWEFIRKQVALGHQAYVICPMIEENEKMDLENVEEYARMLSQALPPSITVEALNGH
                     MRPAEKNDIMERFSKNEIQILVSTIVVEVGIDVPNATVMLIENAERFGLAQLHQLRGRV
                     GRGKAQSYCVFISGSEKEEAMERLSIIGHSNDGFEIANEDLKLRGPGEFFGVKQSGTMN
                     FALGDIYSNADILKMASEAVDYLKKEGYNFQKLHQYSLEKNLNFAKNI"
     CDS             complement(2205..3914)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dak2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_18"
                     /sec_met_domain="Dak2 (E-value: 2.7e-40, bitscore: 128.9,
                     seeds: 138, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VNSHTIDAKTFQKLFLAGANRINSRKDYINELNVFPVPDGDTGTN
                     MSLTILAAAKEVGAVAEPTMATICKAISNGSLRGARGNSGVILSQLFRGFTKAVSKADS
                     LGKDEITAGFTRAVETAYKAVMKPKEGTILTVAKGMADKAEELVDEDMDVIAFCEAIVA
                     YGYEVLSKTPDMLPVLKEAGVVDSGGQGLMEVLQGIVDALTGKVTDIEVPAEAASMSSA
                     VISAPKADISTADIKFGYCTEFIILLDKPLTKEDEKGLKKFFLSIGDSLVLVADEEICK
                     VHVHTNHPGEAFEKALTFGALSNMKIDNMRLEHQEKLIKDSENEAARQRQQEAEEEELA
                     AKEAAAEKPAKEVGFIAVSVGEGLTDIFKGLGVDYLIEGGQTMNPSTEDMLNAIEQVNA
                     KNIFILPNNKNIILAAEQARDLIEDKKIIVLPTKTIPQGISAMIGYMPEAGVDENEENM
                     KEAYQDIASGQVTYAVRDTVIDGKEIHNGDIMGINDDGIAAVGKNLTETTLELLSTMAD
                     EDSELICLYYGADVTKDDADTLSDAIEDKFPECEVEVNFGGQPIYYYMISVE"
     CDS             complement(4083..4439)
                     /locus_tag="ctg28_19"
                     /transl_table=11
                     /translation="MKGQMHTDLGQVIIDEEVIATYAGINAIECFGIVGMASVNMKDGF
                     AQLLKRDNVSKGVHIKINDNKIYIDFHIIVVYGVSIATVTENLIQNVKYRVEKFTGMSV
                     EKINIYVEGVRIVD"
     CDS             complement(5281..5721)
                     /locus_tag="ctg28_20"
                     /transl_table=11
                     /translation="MDKQNFDTTVNSLFSGMDHVLSSKTVVGEPQVIGDTIILPLVDIS
                     FGMGAGAFNKEKGSSAGGGIGGKMSPSAILVIHNGQTKLVNIRDQDAVTKVLDMVPDAV
                     NKVVSIIKGEDAEDKVDPEVESAVNKAAQAEASVVDVDGAGI"
     CDS             complement(5737..6666)
                     /locus_tag="ctg28_21"
                     /transl_table=11
                     /translation="VLYVLLLLLKILGILLLLFIGLVLLVLLTPIQYSFELEKEEQREP
                     KFMVRVTWLFWLFYFKTSYIEKVFDYRIRILGYQIAGNQPEFLEKQKERQKKKSQKEKA
                     KEERKTAETPAEGKSRSIDSVSKQKAEKAVPKEKSSDVSEGREKTKEKDSGDDKNSKDK
                     KKNKEKKQKDGKKPKKESSLKKIKSKIKSLKETKVNLDKMPWREWLELGKDVLIRFLKH
                     ALPGKLEGNIAFGTGNPEYTGYITGIAAVFYPKYGEHFSLYPDFERKMFEAKCRGRGRI
                     RLGYMLVLAVSILKEKSVRTMIKNIILG"
     CDS             complement(6682..6858)
                     /locus_tag="ctg28_22"
                     /transl_table=11
                     /translation="MYILSSREMRQKFYQNNDLKLLGLAGSMKEAYEIVLKLVQMGYNS
                     DCIYEMNDYLEKF"
     CDS             complement(7108..7923)
                     /locus_tag="ctg28_23"
                     /transl_table=11
                     /translation="MNWLDKLERKFGRYAIRNLPLYIVMLYAIGAVLNILTKGSYYYYV
                     ALNPYMILHGQIWRLLGFLIVPPNASLIFIIFVLMFYYSIGESLVQVWGAFRFNMYILI
                     GVLATIVASFIVYFIYPSTMIFMDTFYLNLSMFLAYATIFPEMRVYLYGILPLKVKWMA
                     WFDVALLVWQFVVGGLGARIAIVVSLLNFLLFYFSSRNYKKVSPKEIHRKRAYRKASSV
                     ASNKPYRHKCAVCGKTELDDPNLEFRYCSKCNGNYEYCNEHLFTHTHVK"
     CDS             complement(8070..9008)
                     /locus_tag="ctg28_24"
                     /transl_table=11
                     /translation="MIRIFKTTDSGIRKVAVAEEGCWIALTNPTAEELSTTADQFNIDV
                     DDLKSPLDEEERSRIQVEENYTLIILDIPTIEERKGREYFYTIPFGIIFTDKYIFTVCL
                     VDSPVLTVFMDGRVRDFYTYKRTRFIYQMLYRNATMFLQYLKIIDKKSDEVEKKLHISQ
                     RNQELIEMLDLEKSLVYFTTSLRGNEVVLEKLMRNTSIPRYEDDEELLEDVIIENKQAI
                     EMAKIYSDILSGTMDAFASVISNNLNIAMKFLSVITIVLTVPTIVTSALGMNVAGIPFA
                     NNPYGFWIVVGISLLLTLIAGAIIAKNKHFK"
     CDS             complement(9204..9575)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_25"
                     /sec_met_domain="LysM (E-value: 2.5e-14, bitscore: 44.0,
                     seeds: 155, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEKVYVNICDTKKCPGPVYAVKTGDTLYSIAQRHHCRVRTLLDL
                     NPFVDIYNLQPGEEICVPDCRGQGKVDFRPYVVKEGDTLKIILKNVSMTFEELAKVNRI
                     LYNLTVPAGTILLVPAKKE"
     CDS             10001..14239
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_26"
                     /sec_met_domain="HGD-D (E-value: 7.4e-64, bitscore: 207.2,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 4.8e-37, bitscore:
                     118.6, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHALGIDIGSTTVKVTVINESHDILFSDYKRHFANIKGTLQTLL
                     SEAREKLGNLTIHPTVTGSGGMAISEYLHIPFCQEVVCVANALQDYEPKTDVAIELGGE
                     DAKIIYFNNGIEQRMNGVCAGGTGSFIDQMASLLQTDATGLNEYARDYDTLYPIAARCG
                     VFAKSDIQPLINEGATKENLAASIFQAVVNQTISGLACGKPIKGYVAFLGGPLHFMPEL
                     KNAFIRTLNLDEEHIIDPPYSHLFAAKGAALNAKEECSFTLDDLLKEFESDIQLAVEVE
                     RMEPLFKDEKEYDEFIEEHNQFKVKKADLATYSGKCYLGIDAGSTTTKLALVGEDGSLL
                     YRFYDNNNGSPLNTTIRAMKELKELLPPAAKISGSCSTGYGEALIKAALQLDHGEVETM
                     AHYYAAAFFEPDVDCILDIGGQDMKCIKIRNHAVDNVLLNEACSSGCGSFIETFAKSLN
                     YSVADFAKVALFAPSPIDLGSRCTVFMNSKVKQAQKEGASVGDISAGLAYSVIRNALLK
                     VIKLTDPKQLGKKIVVQGGTFYNDAVLRSFERISGCHAVRPDIAGIMGAFGAALIARER
                     EEETGDTQMLSIDEIINLEYSTSMSRCQGCNNHCILTINKFNNDRQFISGNRCERGLGL
                     EKNHEHVPNLYEYKYKRIFGYKALKPDEAKRGVIGIPRVLNMYENYPFWYTFFTNLSFR
                     VLLSPKSSRKIYELGIESIPSESECYPAKIAHGHVMWLLKKGINTIFYPCVPYEEDQME
                     GANNHYNCPIVTSYAENIKNNMEELRDPNVLFMNPFLALDNADALKVRLYDELSKHFDV
                     TKEEIDHAVDEAYKEAAQVRKDVQAKGEETLAYLAETGKMGIVLCGRPYHIDPEINHGI
                     PELINSFGIAVLSEDSICHLGHVERPLIVSDQWMYHSRLYAAANYAKKNKQLEVIQLNS
                     FGCGLDAVTTDQVNDIMTNSGRIYTVLKIDEVNNLGAARIRIRSLIAAVKIRNRKHIEP
                     HPVPANIEKVEFTKEMKKDYTILIPQMSPIHFDLLTPAFRHCGYNVEILPEMGKQAVDT
                     GLKYVNNDACYPSLIVVGQIMTALTSGKYDLNKTAVIISQTGGGCRATNYIGFIRRALA
                     KNGYGQIPVISLSVQGIEKNEGFKFTPALLVRALQGVIYGDLFMRVLYRVRPYEKVKGS
                     ANHLHEVWKKRCIKSLEKARYGEFKKNIRGIIRDFDRLPITDEKKPRVGIVGEILVKFL
                     PDANNHLIELLEEEGAEAVMPDLLDFMFYSFYNSNFKAEYLGKSTKAAKLCNMAISALE
                     AYRGFLRKELERSDRFTAPPHIEELAEYAKPIVSLGNQTGEGWFLTGEMVELIKQGAPN
                     IVCTQPFACLPNHVVGKGVIKELRRKYPESNIVAIDYDPGASEVNQVNRIKLMLATAEK
                     KLKSDLPQAR"
ORIGIN
        1 caatttccat tcggttttta aatatttttt gcaaaattca aattcttctc cagagaatac
       61 tgatgcaatt tctggaaatt atatccttct ttctttaagt aatccactgc ctcagaagcc
      121 atttttaaaa tatctgcatt cgagtaaata tcgccaagtg caaaattcat cgttccactt
      181 tgttttacac caaaaaactc tcccggacca cgaagtttta aatcttcatt ggcaatctca
      241 aatccatcat tagaatgtcc gataatggaa agacgttcca tcgcttcttc tttttctgaa
      301 ccagaaataa agacacagta tgactgtgct tttcctcttc caacacgtcc gcggagctga
      361 tggagctgag caaggccaaa ccgttccgca ttctctatga gcataacggt tgcatttgga
      421 acatcgatac cgacttctac aacgatagta gaaactaaaa tctgaatttc attcttcgaa
      481 aagcgttcca taatatcatt cttttctgcc gggcgcatat gtccatttaa agcttcaacg
      541 gtaatagaag gcggtaatgc ctgcgaaagc attcttgcat actcttccac attttccaaa
      601 tccatttttt cattttcctc aatcatcgga cagatcacat atgcctgatg tccaagtgct
      661 acctgctttc ttataaattc ccatgcagcc ggacgatagg aagttcccac aacagaattt
      721 ttaatcggca gtctggaagc cggcatttca ttcataatgc taacatctaa atctctgtac
      781 aaaataattc ccagtgtacg tggaatcggc gtcgcactca ttacaagaac atgggggtct
      841 ttcccttttt tcataaaggc atctctttgt tttactccaa aacgatgctg ctcatcggta
      901 acaataaatg caagattgtc aaaagctaca tcgtcctgta tcactgcatg cgttccaatt
      961 aaaatttgaa tctcaccaga ggcacaggct gcctttatct ctcttttttc ctttgctttt
     1021 gtggaaccgg taagcagggc aacggtaatc ccaagtgggg aaaggagttt cacaaagttc
     1081 tggtaatgct gttctgcaag tacctctgtc ggagccatca acgccgcttg gtaaccggca
     1141 agaacagcag catacatcgc tgtcattgct acaatcgtct ttcccgaacc aacgtctccc
     1201 tgtaaaaggc ggttcattgc cattgtatcg gaaaagtcct ggcgaatttc atttaacacc
     1261 tttttttgtg cccctgtaag aggatacggt aaattttcta caaacctctt tacgggttct
     1321 tccattggaa taatatagtg attgagtgct tgttcctccc tgtctttgac aagttctaac
     1381 gcactgaaaa aacggaaaaa ttcatcaaaa atgattcgct ttttcgcctc catcaaatgt
     1441 tcggtccctg taggaaaatg tacttctcta agtgctgtat tcactggttc taaatcataa
     1501 taatttcgaa cggtttccgg aagatactct tcttctctgt acatttcaaa tgcagctgcc
     1561 tgtgcttttt gtactgtctt attcgacaat cctgttgtga gagggtaaat cggctgaaat
     1621 gtttccatta actgcaaata tttttccctc ttacagtact ccggctgttc taacataaga
     1681 cgtccatctt tataaatcgg agttcctgta aaaatccacc gttctccctg ttttaatgta
     1741 tttcgaagat atggcatatt aaaccagcgc acaaaaagct gtccgctgac atctgcgata
     1801 agcccggtac aaagttttaa cttccgaaca gtctttagat gaatcgggga agcgatttct
     1861 gcctcaatcg aacatctttg tcctgtcttt atctctgata tggaaattgg ctctggataa
     1921 gtcgtgtagc aacgaggata gtgatgcacc aactgatcca cggtctctat ggcaagcttt
     1981 gcaagtaact tttccgtctt ttctccaatt cctttaattt cccttactgg tattcccaac
     2041 tgagattctc cttcctccac atgcatcatg tggtaatatt attttatctt aatcaaaaca
     2101 ctcttatata aaaatagcag cgattccatg tcaatacacg gaattgctgc cacaaaggag
     2161 tgatttattc cctctttttt cattatatca ttatttcatt tatcttactc gacagaaatc
     2221 atataataat agattggctg tccgccaaag ttgacctcta cttcgcattc tgggaactta
     2281 tcctcaattg catcggaaag tgtatctgca tcatctttgg ttacatcggc tccatagtaa
     2341 aggcaaataa gttccgaatc ttcatctgcc attgtagaaa gtaattctaa tgttgtctca
     2401 gtaagattct ttcctactgc agcgattcca tcatcattga ttcccatgat gtctccatta
     2461 tgaatttcct ttccatcaat tactgtgtct cgtaccgcgt aagtaacctg accgcttgca
     2521 atatcctgat aagcctcttt catattctct tcgttctcat ccacacctgc ttctggcata
     2581 tatccaatca ttgcggatat tccctgtgga attgtctttg ttggaagaac gataatcttc
     2641 ttgtcttcta ttaaatctct ggcctgctct gctgcaagaa taatattctt attatttggc
     2701 aggataaaga tattctttgc attgacctgc tcgattgcgt taagcatatc ctctgtgcta
     2761 ggattcatcg tctggccgcc ttcaataagg taatctacac caagaccttt gaaaatatcg
     2821 gtaagtccct caccaacaga tactgcaata aatccaactt ctttggctgg tttttctgca
     2881 gctgcttctt tagcagcaag ttcctcttct tctgcttcct gctgtctctg acgggctgcc
     2941 tcattctctg aatctttgat gagcttctcc tgatgctcta agcgcatatt gtcaatcttc
     3001 atattagaaa gcgcaccaaa tgttaaggcc ttttcaaagg cttctcctgg atgatttgtg
     3061 tgtacatgta ctttacaaat ctcttcatcc gcaactaata ctaaagaatc acctatagaa
     3121 aggaagaact tctttaatcc cttctcatct tcttttgtga gcggcttatc taacaaaata
     3181 ataaattctg tacagtagcc aaatttgata tctgctgtag aaatatctgc ttttggtgca
     3241 ctgattactg cagatgacat agacgctgcc tctgccggaa cttcaatgtc tgttaccttg
     3301 ccggtaagag catcaacgat tccctgtaac acttccataa gaccctgtcc gccagaatct
     3361 actacacctg cctcttttaa taccggaagc atatctggtg tcttagaaag gacttcgtag
     3421 ccataggcaa cgattgcctc gcagaatgcg ataacatcca tatcctcatc gactaactct
     3481 tctgccttat ctgccattcc ttttgcaacc gtaaggatag ttccttcttt tggcttcata
     3541 actgccttat acgctgtctc tactgctctt gtaaatccgg ctgtaatctc atccttacca
     3601 agagaatccg ctttagaaac tgcctttgtg aatcctcgga ataactggga aaggattaca
     3661 ccagagttac cacgggctcc acgaagagaa ccattgctga tagctttaca tattgtagcc
     3721 attgtaggtt cagcaactgc tccaacttcc ttagctgctg ctaaaattgt cagggacata
     3781 tttgttccgg tatctccatc gggaaccgga aatacattca gttcgttgat ataatctttt
     3841 ctggaattaa tacggtttgc accggctaaa aacaatttct gaaaagtttt tgcgtctatg
     3901 gtgtgactgt tcacaacatt tcctccttat ttacctgttt tatctataat tcatagtagt
     3961 tatcttgttc ttttattcta taaaaaggaa ttccttctaa agcgttatct tagagcgtgt
     4021 ttgaaaaatc attccagcaa cctgcacgcc ccaatttgca gaaagcattt ttcaaacacg
     4081 ttctaatcta cgatacggac tccctctaca taaatattaa ttttctctac actcataccg
     4141 gtaaacttct ccacgcggta ctttacattc tggattaaat tctctgtaac tgtagctatg
     4201 gagacaccat atactacaat aatatgaaaa tctatataaa tcttgttatc atttatcttg
     4261 atatgaacgc ccttgcttac attgtctctc tttaaaagct gggcaaaacc atctttcata
     4321 ttcacagatg ccattccaac gataccaaaa cactcaatcg cgttaattcc ggcataagtt
     4381 gcaataacct cttcatctat aataacctga cctaaatcgg tgtgcatttg tcccttcata
     4441 tactatccct ccgttttatt atcgttttct atagtataac ctcttttcgg tgaaattgga
     4501 accacaaaca taaaattctt ccattttaag tgctttctcc tgaaacaaaa gaagtatctt
     4561 cccatatatt attataagga acatattggg gagattttat gaaaaaatta tgcggattcg
     4621 ctcttttttg cttttccttt ggtctgttcc tgagctgctt tctcaccggc tttgcagtaa
     4681 agtttattat tctggtcatc agcatcctgc ttggatatct gctgttttgt gaccgatttt
     4741 aacagaaaag aaaaaagagg gaatcactga ttccctctta actcatatct gcatacattc
     4801 ctgtaaggac aaagattaga gtcttctctt atcctcagtg acagtaaaac tacgcacgtt
     4861 ctactttacc tgatcttaaa caagaagtac aaacatacat tttcttagaa gctccgttca
     4921 ctttcactct tacagactta atgttggatt tccacatttt gtttgatctt ctatgtgaat
     4981 gactcacttt gataccgaaa tgagcacctt tgtcacaaat agcgcatctt gccatgatag
     5041 cacctcctcg cgaatatact taagtctgac agacttacaa cgagtctata ctatcagaaa
     5101 tcaaaacaaa ttgcaaggaa aacttttaaa aatcttcact ttttttattt gattgatcta
     5161 aggcaaccca aagtgtgttt aaaaaccgct ttctatacga tatgcattac acttcgtgga
     5221 agatttttcc tgcacgaaaa taacgtggta atctcacgtt aactgaatac cgaatacctt
     5281 ttaaattcct gcgccatcta catctacaac agaagcctct gcctgtgctg ctttattcac
     5341 cgcagattct acttccgggt caactttgtc ctctgcgtcc tctcccttaa taatagaaac
     5401 aactttattt acggcatctg gaaccatatc aagtactttg gtaacggcat cctgatctct
     5461 gatattgaca agctttgtct gtccgttatg aataactaaa atagcacttg gggacatttt
     5521 acctccgatt ccaccgcctg cactgcttcc cttttcttta ttaaaggccc ctgctcccat
     5581 tccaaaggaa atgtcaacaa gtggcagaat aatcgtatct ccaataacct gtggttctcc
     5641 aacaactgtc tttgaagata atacgtggtc cattccacta aataaagaat tcactgttgt
     5701 atcaaagttt tgtttatcca ttgtacgccc tcctgtttaa cctaaaatga tgtttttaat
     5761 cattgttctt acacttttct cttttaatat agaaacagcc agaacaagca tatatcccag
     5821 ccggattctt cctcttcccc tgcacttggc ctcgaacatc tttctttcaa aatccggata
     5881 taaagaaaaa tgttctccat acttcggata aaaaacagcc gcaattcctg taatatatcc
     5941 tgtatattcc ggattaccag ttccaaatgc aatgtttcct tctagctttc ccggaagagc
     6001 atgctttaga aagcgaataa gaacgtcctt tcccagctct aaccattctc gccacggcat
     6061 tttatctaaa ttaacctttg tttcttttaa gctttttatt ttgcttttta ttttctttaa
     6121 agaagactct ttctttggtt tctttccatc tttttgcttt ttttctttat tctttttctt
     6181 atctttacta tttttatcat ctccagagtc tttctctttt gttttttctc tgccttctga
     6241 cacatctgag gatttctctt tagggactgc cttttccgct ttctgtttag aaacagaatc
     6301 tatgcttcga ctttttccct ctgccggtgt ctctgctgtt ttacgttctt cttttgcttt
     6361 ttccttttga gacttctttt tttgccgttc tttctgtttt tcaagaaatt ccggctgatt
     6421 cccggcaatc tgatacccca gtatacgtat ccggtaatca aagaccttct ctatgtaact
     6481 ggtcttaaaa taaaaaagcc agaacagcca ggtaactctt accataaact ttggttccct
     6541 ctgttcctcc ttttcgagtt caaaagaata ctgaatcggc gttagcagaa caagcaaaac
     6601 aagtccgata aataacagga gcagtattcc aagtattttt aatagtaata ataatacata
     6661 cagcacattt ctcctcctgt tttaaaactt ctccagataa tcattcatct catagataca
     6721 atcactatta tatcccatct gcacaagttt taacacgatt tcataagcct ctttcataga
     6781 acctgcaagt cccaacagct ttaaatcatt gttctgataa aacttctgtc tcatctctcg
     6841 tgaagaaaga atatacatga tcacatcttt cccacaggaa gtcgtaatac cataccaaag
     6901 tcctttcttc catataaaag gatggcggac tccccgcaat atagccttcg catcgtggga
     6961 aatcgtctcc ccaatcatta tatgttctga tattgtcaac aaaagaccgc ctcctgtcat
     7021 gatttatttg caacttatat tatatcttta ttctatccat taatttttca gatttatttg
     7081 aaagaatata actcttttaa tattgcttta ttttacatgc gtatgtgtaa ataaatgttc
     7141 attgcaatat tcataatttc cattacactt tgagcagtaa cggaattcta aatttgggtc
     7201 atctaattct gtcttaccac agactgcaca cttatgacga tatggtttat ttgaagccac
     7261 agatgatgcc ttccggtatg ctctctttct gtgaatctct tttggagaaa cctttttata
     7321 attccttgat gagaagtaaa acagcagaaa gttcagtaaa cttactacaa tagcaattct
     7381 tgctccaagt cctccaacga caaactgcca aactaaaagc gccacatcaa accacgccat
     7441 ccactttact ttcagcggaa gaataccata aagatatacc cgcatctccg ggaatatcgt
     7501 ggcgtaggct aaaaacatgg ataagttcaa ataaaaagta tccatgaaaa tcattgttga
     7561 tggataaata aaatatacaa taaatgatgc cacaattgtc gcaagaactc ctataaggat
     7621 atacatatta aagcgaaatg ctccccatac ctgtactaaa gattctccaa tcgaatagta
     7681 aaacatcagt acaaaaataa taaaaatgag acttgcattc ggtggcacaa taaggaaacc
     7741 aagcagtctc caaatctgtc catgaagtat catatacggg tttaatgcga cataatagta
     7801 ataagaaccc tttgtcaaaa tattaagtac cgctcctatc gcatacagca taacgatata
     7861 cagcggcaga tttcgtatcg catatcttcc aaatttacgt tccagcttat ctagccagtt
     7921 catggtactc ctcctttaac tttcaatgta ctgacaagaa accttctgca aaaacaagtg
     7981 cagtaaaaat cccaagcgta cattcttaat aaaatatttt tgtttataaa tgaacagccg
     8041 gaaatcccgg ctgtctcata catattcaat tatttaaaat gtttattctt ggcaatgatt
     8101 gctccggcaa tcagagtcag taataaagag attcctacaa caatccaaaa tccatatgga
     8161 ttattcgcaa atggaattcc tgctacgttc ataccaagcg cacttgtaac aatcgttggt
     8221 acagtaagca caatggtaat aactgacaaa aacttcatcg caatatttaa gttattcgat
     8281 ataacagaag caaaggcatc cattgttcca cttaaaatat cactataaat cttcgccatc
     8341 tcaatcgcct gcttattctc gatgataaca tcttcaagta actcctcgtc atcttcataa
     8401 cgtggaatgg atgtattacg catcagtttc tcaagaacaa cctcgttgcc tcgcagagaa
     8461 gttgtaaaat atacaagact cttctctaaa tcaagcattt caatcaattc ctgatttctc
     8521 tgagaaatgt gaagcttctt ctccacttca tcactcttct tgtcaataat cttcagatac
     8581 tgcagaaaca tcgtcgcatt gcggtataac atctggtaga tgaaacgagt tctcttatac
     8641 gtataaaaat ccctcactct tccatccata aatacggtca gtaccggtga gtctacaaga
     8701 cagacggtaa atatatactt atcagtaaag ataattccaa acggtatcgt atagaagtat
     8761 tctcttccct tacgctcttc gattgttgga atatccagga taattaatgt gtaattttcc
     8821 tccacctgta tacgggaacg ttcctcctca tccaaggggc tttttaaatc gtcaacatca
     8881 atgttgaact ggtctgctgt ggtacttaat tcttctgccg taggattggt aagggctatc
     8941 cagcatcctt cctctgccac tgcaactttg cgaatccctg aatcggtcgt tttaaaaatt
     9001 cttatcatga gacttccctc tttcaacagt ttatcgtatc tcagtctgca tcttctctat
     9061 cttggcaaaa cgaaagaaag agtccgtttc gcggactctt acataactga aaccgtttaa
     9121 atttattata agaaatatct aatactttgt caaacgcatt tctgtgattt ttttactatt
     9181 ttttaactgc ttttcttttt catttattct ttttttgcag gaacgagcag aatcgttccc
     9241 gctggtacag taagattata caaaatacgg tttacctttg ctaattcttc aaaggtcatt
     9301 gaaacatttt tcaggataat ttttaatgta tccccttctt ttactacata aggccggaaa
     9361 tctactttcc cctgtcccct gcagtctggt acacagattt cctcacccgg ctgcaaatta
     9421 tatatatcta caaaagggtt tagatcaaga agtgttctta cccggcaatg atgcctttgt
     9481 gcaatgctat acagcgtatc tcctgtcttt actgcataca ccgggccggg gcattttttg
     9541 gtgtcacata tgtttacata aactttttca ctcatagatg ctcttccttt ttcttcctca
     9601 attataaaat atgacagtca gagaaaaagg tactttatcg tgaaaaactc ctcatacaaa
     9661 tactcccctc ttcttttgct ttttgtaaac attttccatt cattatatct ttttttcgaa
     9721 atttgttgta ttttacgttc aactcgttta taatggtttg gatattgaga aatttatcta
     9781 tatatagtga ttcagagcca tagtgtctgt ctcattgcct ttctgtcaaa taacgcagaa
     9841 tgctttttca tcaacaaagt gactgaacaa gacgatacgg tggcatcggc aagcgaagtg
     9901 tatcgcggac ggtgttataa atgtattctg aacattagat taccttattt taatacacaa
     9961 catgaataca cattttacta aaggagatga ttaattaatc atgaaacacg cattaggtat
    10021 tgatattggt tctactaccg ttaaggtaac agttatcaat gagagccatg atatcctttt
    10081 ttccgattac aaacgacatt ttgcaaatat taaaggaact ttacagacct tattatctga
    10141 ggcgagagaa aagctaggca atctcacaat ccatccaacc gtaactggtt ccggtgggat
    10201 ggcaatctca gaatacttac atattccatt ctgtcaggaa gtagtttgtg tggcgaatgc
    10261 cttacaggat tatgaaccaa aaacagacgt agcaatcgaa cttggcggtg aagacgccaa
    10321 gattatttat tttaataacg gaattgagca gcgtatgaac ggtgtatgtg ccggtggtac
    10381 tggttctttc atcgaccaga tggcaagtct tttacagaca gatgcaaccg gtcttaatga
    10441 atatgcccgt gattacgata ccctctatcc aatcgccgct cgttgcggtg ttttcgcaaa
    10501 gtctgatatt cagccattaa tcaatgaggg ggcaacaaaa gaaaatcttg ctgcttctat
    10561 cttccaggct gtagtaaacc agacaatcag tggtcttgcc tgtggtaaac caatcaaggg
    10621 atatgtcgct ttccttggtg gtcctcttca ctttatgcca gaattaaaga atgcatttat
    10681 ccgtacttta aatctggatg aagaacatat tatcgaccct ccatactctc atctttttgc
    10741 agcaaaaggt gccgcattaa acgcaaaaga agaatgttcc ttcacattag atgatctctt
    10801 aaaagagttt gaatccgaca ttcagcttgc tgtagaagta gaacgtatgg agcctctttt
    10861 taaagacgaa aaagaatatg atgaatttat cgaagagcac aaccaattca aggtgaaaaa
    10921 ggcagactta gctacctaca gtggcaaatg ctatctcggt attgatgccg gatctacgac
    10981 aacaaagctt gctttagttg gagaagatgg ttccctctta taccgtttct acgataataa
    11041 taacggaagt ccgttaaata caacaattcg tgctatgaaa gagttaaagg agttacttcc
    11101 tcctgctgcg aagatttccg gttcctgttc tactggttac ggtgaagcat taattaaggc
    11161 tgcactgcag cttgaccacg gcgaagtaga gacaatggca cattactatg ctgccgcttt
    11221 cttcgagcca gatgtagact gtattttaga tatcggcgga caagatatga aatgtatcaa
    11281 gattcgtaac cacgctgtag ataacgtact tttaaatgag gcctgttctt ctggatgtgg
    11341 ttctttcatc gaaactttcg caaaatctct gaactattct gtagctgatt ttgcaaaggt
    11401 tgcgctgttt gccccatctc caatcgactt aggttcccgc tgcactgtat ttatgaactc
    11461 caaagtaaaa caggcacaaa aagaaggcgc aagcgttggt gatatttctg ctggccttgc
    11521 ttattccgtt atccgtaatg ccttattaaa agttattaag ttaaccgacc ccaaacagct
    11581 tggtaaaaaa atcgttgttc agggtggtac attctataat gatgcggtac ttcgaagctt
    11641 tgaacgtatt tccggctgtc acgccgttcg tccagatatt gccggtatca tgggtgcttt
    11701 cggtgcagcc ttaattgcaa gagagcgtga ggaagaaact ggagatacac agatgctctc
    11761 catcgacgag attatcaact tggaatacag cacttccatg agccgctgtc agggatgtaa
    11821 caaccactgt atccttacca ttaataagtt taacaacgac cgtcagttta tttctggtaa
    11881 ccgttgtgaa cgtggtcttg gccttgaaaa gaatcatgag catgtaccaa acctttacga
    11941 atataaatat aaacgaattt ttggatataa agcattaaaa ccagacgagg caaaacgtgg
    12001 tgttatcggt attccacgag tactgaatat gtatgagaac tatccattct ggtatacatt
    12061 ctttacaaac ctttctttcc gggtattgct ttctccaaag tcttcccgaa agatttacga
    12121 gcttggtatt gagtccattc caagtgaatc cgaatgctat cctgcaaaga ttgcacacgg
    12181 acatgtaatg tggcttttaa agaagggtat caacaccatt ttctatcctt gtgttcctta
    12241 tgaggaagat cagatggaag gtgccaacaa ccattacaac tgcccgatcg taacatctta
    12301 tgcagaaaat attaaaaaca acatggaaga gctccgtgat ccgaatgtcc tttttatgaa
    12361 cccattctta gcactcgata atgcggatgc cttgaaggta cgtctttatg acgagttatc
    12421 taaacatttc gatgtaacaa aagaagagat tgaccatgcc gtagatgaag cttataaaga
    12481 agctgcacag gtaagaaaag atgtacaggc aaagggcgaa gaaactcttg cttatctcgc
    12541 agaaactgga aagatgggta ttgttctttg tggtcgccct taccatatcg acccagagat
    12601 taaccacggt attcctgaac tgattaactc tttcggcatc gccgtattaa gtgaagattc
    12661 catctgtcac ttaggtcatg ttgaacgtcc attaatcgtt tctgaccagt ggatgtatca
    12721 ttcccgtctg tacgctgccg caaactacgc aaagaagaac aagcagttag aagtcattca
    12781 gcttaactcc tttggctgtg gtcttgatgc ggtaactact gaccaggtaa atgatattat
    12841 gacgaattcc ggacgtattt ataccgtcct taagattgat gaggtaaata acttaggtgc
    12901 tgccagaatc cgtatccgtt ctctgattgc tgccgtaaag atcagaaacc gtaagcacat
    12961 tgagccacat ccggttccag caaatatcga aaaagtagaa tttacaaaag aaatgaaaaa
    13021 ggactacacc attctgattc ctcagatgtc cccaattcat ttcgacctgc tcacccctgc
    13081 cttccgtcac tgtggctata acgtagagat tttgccggaa atggggaaac aggcagtaga
    13141 tactggatta aaatatgtaa ataacgatgc ctgctatcca tctcttatcg ttgttggaca
    13201 gattatgact gccttaactt ccggcaaata cgatctgaac aaaacagccg ttatcatctc
    13261 ccagactggt ggtggctgtc gtgcgacaaa ctatatcgga ttcatccgcc gtgcattagc
    13321 taagaacggt tacggtcaga ttccagttat cagtttaagc gtacagggaa ttgagaagaa
    13381 tgaaggtttt aaattcactc cggcactttt agttcgtgct cttcagggag ttatttacgg
    13441 agatttattt atgcgtgttc tctaccgcgt ccgcccatac gaaaaagtaa aaggttctgc
    13501 aaatcattta catgaagtat ggaaaaagcg ttgtattaaa tctcttgaga aagcacgata
    13561 tggagaattt aagaaaaata tccgcggcat tatccgcgac tttgacagat taccaatcac
    13621 agatgagaag aaacctcgtg ttggtatcgt tggagaaatc ctcgtaaaat tccttccaga
    13681 cgcaaacaac catctgatag aacttttaga ggaagagggg gcagaggcag taatgccaga
    13741 tttattagac tttatgttct actccttcta caacagtaac tttaaagcag aatatctcgg
    13801 aaaatctaca aaagctgcta agttatgtaa tatggcaatc tccgcacttg aagcttaccg
    13861 aggcttcctt cgaaaagaat tagaaagaag cgatcgtttc actgcaccac ctcacattga
    13921 ggaacttgcc gagtacgcaa aaccaatcgt atccctcggt aaccagaccg gtgagggatg
    13981 gttcttaact ggtgaaatgg ttgaacttat caaacagggt gccccaaaca ttgtatgtac
    14041 acagccattt gcctgcctgc caaaccacgt tgtaggtaag ggtgttatca aggaactgcg
    14101 ccgtaagtat ccggaatcta atatcgtcgc aattgactac gatccgggag caagcgaagt
    14161 aaaccaggta aaccgaatta aattgatgct ggcaacagcg gagaagaagt tgaaatctga
    14221 tttgccgcag gcaagataga cgccaaacaa acgccctctg agaatgaaag tggtgtgcat
    14281 cccgtcaagt agacaattaa aaaaatataa aatttttgtg ttgcccggtg tatatcgggc
    14341 aacattt
//
