LOCUS       c00100_gnlPro..        11373 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GHDGKICM_100.
ACCESSION   c00100_gnlPro..
VERSION     c00100_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 02:47:14
            Original ID  :: gnl|Prokka|GHDGKICM_100
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11373
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11373
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:3759]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..3759
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..11373
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11373
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..211
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_1"
                     /sec_met_domain="CT_Btheta (E-value: 3.8e-18, bitscore:
                     55.1, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="INTDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRK
                     RLIAAYEMLYGKKVTPVTKKHTAV"
     CDS             224..568
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_2"
                     /sec_met_domain="OAD_gamma (E-value: 6.3e-28, bitscore:
                     87.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSADKLV
                     VRSIKRVKRR"
     CDS             663..1031
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.6; E-value:
                     4.3e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 9.7e-22, bitscore:
                     66.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEASAAPVSTPAAVPAPAKKAAP
                     KTSGSAGAVKITAPMPGKIVAVKAQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             1065..2189
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_4"
                     /sec_met_domain="OAD_beta (E-value: 1.3e-157, bitscore:
                     514.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVST
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGAEA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             2347..3759
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_5"
                     /sec_met_domain="HMGL-like (E-value: 8.4e-44, bitscore:
                     139.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 4.3e-59, bitscore:
                     189.5, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDACLRFLKEDPWERLRKLRDGFKNTKLQMLFRGQNILGYKPYPDDVVE
                     YFVQKSIANGIDVIRIFDCLNDLRNLQTAVDATKKEGGHAQIALSYTIGDAYTLDYWKK
                     TAKNIEEMGADSICIKDMAGLLVPNEATRLVTALKQATDIPIELHTHYTSGVGGMTYLK
                     AVEAGVDIIDTAISPFAMGTSQPATEVMAETFRGTEFDTGFDQKLLGEIADYFRPIREK
                     YIANGLMSPKVLGVNIKTLMYQVPGGMLSNLVSQLEQQGASDKFYEVLEEVPKVRKDFG
                     EPPLVTPSSQIVGTQAVLNVLTGERYKMITNESKALLRGEYGQTVKPMNKEVQKKAIGD
                     EKPITCRPADLLEPELSKIEAEMSQWKEQDEDVLTYALFPQVATEFFKYRAAQENKIDP
                     AKADVKNGAYPV"
     CDS             complement(4020..4409)
                     /locus_tag="ctg100_6"
                     /transl_table=11
                     /translation="MKKLFYPAVFHIAEEGGYWVTFPDFPECLTQGENMQEAYDMAIDA
                     LGLILTDDINDHKELPEPSNITHVDDGVVVIIPYDYLEYNRKYHNKSIKKTLTIPEWLN
                     NEALRLNLNFSQILQDALLNKIQSR"
     CDS             complement(4455..4643)
                     /locus_tag="ctg100_7"
                     /transl_table=11
                     /translation="MPMKPKEMIRLLKKNGFIKISQNGSHVKMKNFKTGKQTTVPLHSK
                     DLKKRLEDAILKQAGLK"
     CDS             4868..5011
                     /locus_tag="ctg100_8"
                     /transl_table=11
                     /translation="MNNAVSYAMDSQVIFQMFFSIVCIAAAIGVSILVLRFMRKFIDFL
                     LQ"
     CDS             complement(5060..6088)
                     /locus_tag="ctg100_9"
                     /transl_table=11
                     /translation="MIPIQNIYYMLSYAFQTLQAENYKDLATENFHNTAELCAAILDKG
                     IGIQLKHGLRRDYVSKSESLSTLQGKLNISESIKTQTMLKKQMICTYDEFSTNIQFNQI
                     IKSTVLLLLKANITNSRKKSLRKLLLFFSDVNEIDLHFVNWNQQYNRSNQNYQMLIGMC
                     YLVYKGLLTTQNNGTTKLMDFFDGQRMCRLYEKFLLEYYRKEHPELTANASQIAWQLDD
                     TENQMLPRMQTDIMLSKNNNILIIDAKYYSHMTQQQYGIHTLHSNNLYQIFTYVKNKEF
                     ELRNYEHTVSGMLLYAQTDEDIIPNNTYHMSGNQISVLALDLNQDFSKISRTLDDIAKN
                     FL"
     CDS             complement(6085..7953)
                     /locus_tag="ctg100_10"
                     /transl_table=11
                     /translation="MREIFGSIAGGAAYKFGLFFHKKTQSWTCGSPAKPVKLTENEAIQ
                     KAEEIRNDLVEGAEIISSFGPLNSTADYEQLYKQLEHISGINTVWRMKYYQMLFPILFA
                     PFYGQDIQLDVLHFLNQTPSEIPFIRMGQIALFSKKCNIPGIVFGHIWGRSTNHNNKSN
                     DSETNTLSDKKHKLHYWMYTVFDDTSWMECQQKEIMVLGMNDIGDYSQYDSKESLRQEL
                     ISTYDNSTSRKNQALMAWNFANKLAINDVIFAKRSNTLVGKGIVTGDYIFDDSRQEYKN
                     IRTVKWLQIGEWEHPGKSVAKRLTDITSYTDYIEKLITIFTPDELDDVDTQPEVDYPEY
                     SSADFLSDVYMSEQDYETLVNVLKMKKNIILQGAPGVGKTFTAKRLAYSIIGAKNPDRV
                     QMIQFHQSYSYEDFIEGYRPTENGFTIKKGSFYKFCKLAEDDDENDYFFIIDEINRGNL
                     SKIFGELFMLIEKDKRGIELQLLYSDENFSVPPNVYIIGMMNTADRSLAMLDYALRRRF
                     SFFTMKPGFNTIGFQTYQDSLKSDAFKKLISCIKQLNSKIAADISLGEGFCIGHSYFCG
                     LTAKTATVRTLTSIIEYELIPLLKEYWFDEPEKIIDWSDRLRSTVK"
     CDS             8166..9314
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg100_11"
                     /sec_met_domain="Aminotran_5 (E-value: 6.5e-79, bitscore:
                     255.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIYFDNGATTRALPQVREIMDEVLEKEYGNPSSMHMKGFDAEK
                     YVNHAKEIIAKSLKVDPKEIYFTSGGTEANNLALIGTAFANKRERKHIITSCIEHASVY
                     NPLSFLEDEGFEVTYLPVDEHGIVDLEALKKALRKDTLMVSIMCVNNEIGAIEPVEEIG
                     KIVKSFDPKILFHTDCIQAYGKLNCYPKKWKADMISVSGHKIHGPKGIGFIYIKNGTKI
                     KPIIWGGNQQKGMRSGTENVPGIAGLGKAAELIYENHEEKIAHIREIKDHFIKRVMEEI
                     PDVKDNSGDAPHVASISFLGVRSEVLLHALEEREIYVSAGSACSSNKPEVSGTLKGIGL
                     TKEYYESTLRFSFSIFNTVEEADICVEALKELLPMLRRFTRR"
     CDS             9330..10595
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:Thiamine biosynthesis protein (Score: 226.4;
                     E-value: 8e-70)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg100_12"
                     /sec_met_domain="ThiI (E-value: 1.8e-70, bitscore: 226.4,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSRNLFELDFVTKKTTRVHHIKKEIFMKFKAFLIKYAEIGIKGN
                     NRRFFEDALVRQMKYALKPVGDFSIRKESGRIFVHANEEYDFDEAVESLSHVFGIAGIC
                     PIVVEEDKDFEKIAEVVEKYVDEDYADKHFSFKVHVRRADKKYPIPSMEAAARLGERLL
                     EKFEDLSVDVHNPDVMLTVEIRDKVYIYSREIPGPGGMPVGTNGRAMLLLSGGIDSPVA
                     GYMISKRGVSIDATYFHAPPYTSERAKQKVVDLAKEIAKYTGPITLHVVNFTDIQMAIY
                     EKCPHDELTIIMRRYMMKIAEHFANQDNCLSLVTGESIGQVASQTMHSLYVTNEVCQMP
                     VFRPCIGLDKNEIVKVAEKIGTYETSILPYEDCCTIFVAKHPVTKPRLDVIKRSERNLD
                     DCIDELMKTAIETTEEIKINAH"
     CDS             10603..10797
                     /locus_tag="ctg100_13"
                     /transl_table=11
                     /translation="MDESIFKADISILIMFIMLADKCLFKRWEEEISLKIFVLSEDSYK
                     KNLSVKKEPRKVIFPRLIS"
     CDS             complement(10855..11091)
                     /locus_tag="ctg100_14"
                     /transl_table=11
                     /translation="MKTIKISLNSIDKVKTFVNVINRFDAEFDLVSGRYVIDAKSIMGI
                     FSLDISKPIDLNIHNADNLDEIMEQLQPYLVTE"
ORIGIN
        1 aatcaataca gataagaata agacagcact tatcgcagag aaaactgcgg aatatgcaga
       61 aggacagagc agtgcattag cagctgcaaa gagaggatat atagatgaca tcatcgagcc
      121 ggacgcaaca agaaagcgtc ttatcgctgc ttatgaaatg ctttacggaa agaaagtaac
      181 tccagtgaca aagaagcata cggcagtata gtgaggtgag agtatgaacg tatttgaaca
      241 agccttatta aatactttga tgggtatggg aactgtattt gcagtactga ttttcatttc
      301 tttactgatt tctctttttg tatatatccc atctattgaa agagcgttaa agaatcgttc
      361 ttctaagaaa gagaaaaagg ctgcgcagga agaaagaccg gctccaaagc gtccgattct
      421 tgaagaagtt gtggaagaag aggaacttgt ggatgatggt gaacttgtcg cagtaatcac
      481 agcggcaatc atggcagcga atggaggagc agcagtcagt gcagataagt tggtcgttcg
      541 ttcaatcaag agagtgaaga gaagatagca aaaatgtatt cttggaatct ttttataaag
      601 ttttgaaaag ttagctatag aaagatttta gaagtacata aaatcattca ggaggattta
      661 aaatgaaaaa ttatagaatt acagttaatg gtgttgctta tgatgtagca gtagaagaat
      721 taggtgcagg agaagcaagt gcagcgccgg taagtacacc agcagccgtt ccggctccag
      781 ctaagaaagc tgccccaaag acttccggaa gtgccggtgc cgtaaagatt acagcaccaa
      841 tgccaggtaa gatcgtagca gtaaaggcac aggcaggtgc ttctgtaaag aagggcgacg
      901 ctgttcttgt attagaggct atgaagatgg agaatgaaat ctgtgcagca caggatggtg
      961 ttatcgcaag tgtggaagta gcagttggag atatggtaga aggcggagat gtactggcta
     1021 caatgaacta gagcatattt gcaaaataaa acggaggaag atttatgagt tatgttgtag
     1081 agacaatgac gaatctcgca gcacagaccg gatttgcatt cttaaagcca ggtaacttca
     1141 ttatgatact ggttgcttta gtcttcttat atctggccat cgccaaagga tatgagccac
     1201 ttttgttagt gccgatttct tttggtatgc tgctggttaa cttatatccg tccattatgg
     1261 aagaaggcgg attattacat tatttttact tattagatga atggagtatt ctcccttcac
     1321 tgattttctt aggtgttgga gcactaacag actttggtcc gctgattgcc aatccagcaa
     1381 gtttcttgct gggagctgcg gcgcagtttg gtatttacag cgcgtatttc cttgcaatgc
     1441 ttatgggatt taacggaaag gcagcagcag caatttccat tattggtgga gccgatggtc
     1501 ctacttctat tttccttgcc ggaaagcttg ggcagacaga cttaatggga ccaattgcgg
     1561 tagcggcata ttcttatatg tcacttgtac caattattca gccaccgatc atgaagctcc
     1621 ttactacaga aaaggaacgt cagattaaga tggaacagtt aagaaccgtt acaaaaacag
     1681 agaaaattat gttccctatc gttgtaacag ttgttgtatg tctgattctt cctacaacag
     1741 caccattagt tggtatgctg atgctcggta acctttttag agagtccggc gtagtaaaac
     1801 agctttcaga gacagcgtct aacgctctta tgtacatcgt agttattatt cttggtacat
     1861 ccgttggtgc gacaacaagt gcagaggcat tcttaaatgt cagcacaatc aagattgtag
     1921 tattaggtct tgtagctttt gctgttggta ctgcagcagg tgtcctgttt ggtaaactta
     1981 tgtgtaaggt tacaggtggt aaggtaaatc cattaattgg ttctgccggg gtatctgccg
     2041 ttcctatggc agcccgtgta tcccagaaag ttggtgcgga agcagatcca tcaaacttct
     2101 tactgatgca tgcgatggga ccaaatgttg ccggagttat cggtacagcg gtagccgccg
     2161 gaacatttat ggcaattttt ggagtataat ttagaattat ttgattattt aaaattcatt
     2221 atttataggg ctacaatctg taaaaaatgt tacaggggat atttataaat agtttacaag
     2281 ttgaatttta gataataaca gttgtaagcg caaatagtta cgtgatttga aataaaagga
     2341 gatattatgg ccgaaattaa gaaaaaaccg gttaaaatag tagaaaccgt tctccgtgac
     2401 gcacatcagt ctctgattgc tacaagaatg acaacagagg agatgctgcc aatcgtagat
     2461 aagatggatc aggttggtta tcatgcagta gaatgctggg gaggtgcaac atttgatgcc
     2521 tgcctgcgtt tcttaaagga agacccatgg gagagacttc gtaaattaag agatggcttt
     2581 aagaatacaa agttacagat gttattccgt ggacagaaca tcttaggata taagccatat
     2641 ccagacgatg ttgtagaata tttcgtacag aaatctattg caaacggaat tgatgttatt
     2701 cgtatttttg actgtttaaa tgaccttaga aacttacaga ctgctgtaga tgcaacaaag
     2761 aaagagggag gacacgcgca gatcgccctc tcctatacaa tcggtgatgc atatacatta
     2821 gactactgga aaaagactgc taagaatatt gaagagatgg gagcagattc tatctgtatc
     2881 aaagatatgg caggactttt agtgccgaat gaagcaactc gccttgtaac tgcattaaag
     2941 caggcaacag acattcctat cgaacttcat acacactata caagtggtgt cggtggaatg
     3001 acttacttaa aagcagtaga agcaggagtc gatatcattg atacagccat atctccattt
     3061 gcaatgggaa caagccagcc ggcaacagaa gttatggcgg agacattccg tggtacagaa
     3121 tttgacacag gatttgacca gaagctttta ggtgaaatcg cagattactt ccgtccgatc
     3181 cgtgagaaat acattgcaaa tggcttaatg agtccaaagg tacttggtgt aaacatcaag
     3241 actttaatgt atcaggttcc aggtggaatg ctttctaacc ttgtatctca gttagagcag
     3301 cagggagcat ccgataagtt ctatgaagta ttagaggaag ttccaaaagt acgtaaagac
     3361 ttcggtgaac caccattagt tacaccgtcc agtcagattg tcggaacaca ggctgtatta
     3421 aatgtactta ccggagagcg ttataaaatg attacaaacg agtcaaaagc ccttcttcgt
     3481 ggagaatacg gtcaaaccgt aaaaccaatg aataaagaag tacagaaaaa ggcaatcggc
     3541 gatgaaaagc caattacctg tcgtccagcc gaccttcttg aaccggaatt atctaagatc
     3601 gaggcagaga tgagccagtg gaaagaacag gacgaagatg tgcttacata cgcattgttc
     3661 ccacaggtag caaccgaatt ctttaaatac agagcggcac aggagaataa gattgatcct
     3721 gcaaaagccg atgtaaagaa tggagcatat ccggtgtagg attggattga tttagattaa
     3781 aaacagacga acccccgcaa ctttatagat agcacatgtg aagatttcgc tgcgtagaaa
     3841 atgctcagcc gcatttttac ttgctccgac atcacatttg ctatctataa agttgtgggg
     3901 gttctgtttt ttaacctaaa cttgccggaa atggataggt gaagctatcg tattagctgc
     3961 cttgttaagt atattataat ctatgattgc agtattacca aatgaaagaa ttatagccat
     4021 taacgagatt gaattttgtt taaaagagca tcctgcaaaa tctgtgaaaa gtttaaattc
     4081 aatcgcaatg cttcgttatt caaccattca gggattgtta aagttttttt gatagattta
     4141 ttatgatact ttcgattata ttccaaataa tcatatggga tgattacgac aactccatca
     4201 tcaacatgtg tgatgttaga cggttctgga agttctttat ggtcgttaat gtcatcagtt
     4261 aagataagtc ctaaagcatc tatagccata tcataggctt cttgcatatt ttctccctga
     4321 gttagacatt cgggaaagtc aggaaaagtc acccaataac cgccttcttc tgcaatatga
     4381 aatacagcag gataaaataa ttttttcata atggatacct ccaatgtatg tgagttatta
     4441 tagatgaaat aaggctattt taagcccgct tgttttagga tggcatcttc tagtcttttt
     4501 tttaaatctt tgctatgaag aggaactgtt gtttgtttgc cagttttaaa attcttcatt
     4561 ttcacatggg aaccattttg acttattttt atgaaaccat ttttttttaa taatcttatc
     4621 atttcttttg gtttcattgg catagtatgc cacccctttc tataattata ttataatacg
     4681 tatagtatac gtgtgtcaag aactcggtga tacaactggt gaggaatagt atatcatatt
     4741 taagaagaaa aacaactaat aaatgtaaaa aaatataaaa aatgtaattt ttaaaatgaa
     4801 aaatttttga taaaaataca gagatatggt aaaatgaagt atcaaaagat agtcaggggg
     4861 agatacaatg aataacgcag tttcatatgc tatggatagt caggtgattt ttcagatgtt
     4921 tttttcaatt gtatgtatag cggcagctat aggtgtatcc attttggttc ttcgctttat
     4981 gaggaagttt atagattttt tgttacaata ggggtaatag aagtaaggaa gggatattag
     5041 gtcccttcct ttaaaaattt taaagaaaat ttttggcgat gtcatctaaa gttctggaga
     5101 tttttgaaaa atcctggttt aaatctaatg caagaacaga aatctgattt ccgctcatat
     5161 ggtaggtgtt attaggaata atatcttcat cggtttgtgc ataaagaagc attcctgata
     5221 cagtatgttc atagtttctc aattcaaatt ccttattttt tacataggta aaaatctgat
     5281 aaagattatt ggaatgcaga gtatgtattc cgtattgttg ctgggtcata tgcgaataat
     5341 atttggcatc aataataagt atgttattgt ttttggataa cataatatct gtctgcatcc
     5401 taggaagcat ttgattttca gtatcatcaa gctgccatgc aatttgtgat gcattggcgg
     5461 tgagttctgg atgttctttc cgataatatt caagcaagaa tttttcatat aagcgacaca
     5521 ttcgttgtcc gtcaaaaaaa tccatgagtt tagtagtgcc gttattttgt gttgtcagaa
     5581 gacccttata gactagatag cacataccga ttaacatttg atagttttga ttagagcgat
     5641 tatactgttg attccaattt acaaaatgca ggtcaatttc attaacgtca gaaaaaaata
     5701 gcaatagttt tcttagactc ttttttcggc tgtttgtaat attcgcttta agaagcagta
     5761 atacagtgga tttaataatt tggttaaatt gtatattggt tgagaattca tcataggtac
     5821 aaatcatttg ttttttgagc attgtctggg tcttgatgga ttctgaaatg ttaagttttc
     5881 cctgtagtgt agaaagagat tcggattttg atacataatc tcttcttaaa ccatgtttta
     5941 attgaatacc aattccttta tcaagaatcg ctgcacataa ttctgcagta ttatgaaagt
     6001 tttctgttgc taagtctttg taattctctg cctgtaatgt ttgaaaagca taggacagca
     6061 tatagtaaat attttgaatg ggaatcattt gacggtactc cttaatctat cagaccagtc
     6121 gatgattttt tcaggttcat caaaccaata ttcttttaaa agaggaatca attcatattc
     6181 tataatggat gtaagtgttc ggacagtagc tgttttggca gttagtccac aaaaatagct
     6241 atgcccgata caaaatcctt ctccaagaga aatatctgct gctatttttg aatttaattg
     6301 ttttatgcaa gaaatcaatt ttttaaaagc atcacttttt aaagaatctt ggtaagtctg
     6361 aaaaccaata gtattaaatc ccggtttcat agtaaaaaat gaaaaacgtc gtcttaaagc
     6421 ataatctaac atggcaaggc tacgatcagc agtattcatc atgccgataa tatatacatt
     6481 gggtggtaca gaaaaattct catcagaata taataactgg agttcaatac cacgtttgtc
     6541 tttttcaatc aacataaata attcaccgaa tattttactt aaattaccgc gattgatttc
     6601 atcaataata aagaaataat cattttcatc gtcatcctca gcaagtttgc agaatttgta
     6661 aaaagacccc tttttgattg taaacccatt ttctgtcgga cgatatccct caataaaatc
     6721 ttcataggaa tagctctggt ggaactgaat catttgaaca cggtcaggat tttttgcacc
     6781 aataatagaa taggcaagac gtttggcagt aaatgttttt ccaacaccag gtgcaccctg
     6841 taaaatgata tttttcttca tttttaagac atttaccaat gtttcataat cttgctcact
     6901 catatataca tcggaaagaa aatcagcaga agaatattct ggatagtcta cttcaggttg
     6961 tgtatctaca tcatccaatt catcaggagt aaagatagta ataagttttt cgatatagtc
     7021 agtatatgag gtaatatcag ttaagcgttt ggcaacagac ttaccgggat gttcccattc
     7081 gccaatttga agccacttta cggtacggat atttttatat tcctggcgag aatcatcaaa
     7141 aatataatct ccggtgacaa tacctttacc aacaagagta ttacttcgct ttgcaaaaat
     7201 gacatcattg atcgccagct tgtttgcaaa attccatgcc attaaagcct gattctttcg
     7261 agaggtactg ttgtcataag tgcttatcaa ttcctgacga agagattcct tagaatcata
     7321 ttgagaataa tctcctatgt cattcatgcc gagaaccata atttcttttt gctggcattc
     7381 catccaactg gtatcgtcaa agaccgtgta catccagtag tgaagtttat gttttttgtc
     7441 ggaaagcgta ttagtttcag aatcattaga tttattattg tgattagtgg atcttcccca
     7501 aatatgacca aaaacaatac caggaatatt acattttttt gaaaacagtg cgatttgtcc
     7561 catgcgtata aaaggaatct cgcttggtgt ttgatttaga aaatgtaata catccaattg
     7621 tatatcttgt ccataaaatg gtgcaaacaa tattggaaat aacatttgat aatatttcat
     7681 tcgccatact gtattaattc cagaaatatg ttccagttgt ttgtagagtt gttcataatc
     7741 tgctgtggaa tttaaaggac caaaggaaga tattatttca gcaccttcta ccaaatcatt
     7801 acgtatttct tctgcctttt ggattgcctc attttcagta agctttacag gttttgcagg
     7861 tgagccacaa gtccagcttt gtgttttttt gtgaaagaaa agtccaaatt tataagctgc
     7921 tccaccggca atacttccaa atatttcgcg catatctttg tccatttcaa gtacataaca
     7981 aagattcaat ttatttcctt tttcattttc gcctgtttat ccgcaaaatc cattttactt
     8041 ctctctcatt ttatgttatg tttatatacg attatgccat tttttatggc tgttttttga
     8101 gtgtagagaa tggaacaaaa aaacaataag acataatata ttttttgaag gagttgtaaa
     8161 cgagaatgtc agagatttat tttgacaatg gcgcgaccac aagggcgctg ccgcaggtgc
     8221 gtgagattat ggatgaagta cttgagaagg agtacggcaa tccttcttct atgcatatga
     8281 aaggatttga tgcagagaag tatgtcaatc atgcgaaaga gattattgca aagagcctga
     8341 aagttgatcc aaaggagatt tattttactt ctggcggtac agaggcgaat aatcttgcat
     8401 tgatcggtac tgcatttgca aataaaagag agagaaagca cattattaca agctgtattg
     8461 aacatgcttc tgtatataat ccattatctt ttttggaaga tgagggattt gaagtgacct
     8521 atcttcctgt cgatgaacat ggaatcgtag atttagaggc attaaagaag gcgcttcgta
     8581 aagatacatt gatggtttct attatgtgcg tgaataatga gattggtgcc atcgaaccgg
     8641 ttgaggagat tggaaagatt gtaaagtctt ttgatccaaa gattttattt cataccgatt
     8701 gtattcaggc atatggtaag ttgaattgtt accctaagaa atggaaagca gatatgattt
     8761 ctgtaagtgg acataagatt cacggcccaa agggaatcgg atttatttat attaagaatg
     8821 gaacaaagat aaagccaatc atctggggtg gaaatcaaca gaagggaatg cgttccggaa
     8881 cagaaaatgt accgggaatt gcagggcttg gtaaggcggc agagttgatt tatgagaatc
     8941 atgaggaaaa gatcgcacat atcagagaga taaaagatca ttttataaaa agagtgatgg
     9001 aagagattcc agatgtgaag gataattccg gagatgctcc gcatgtggcg agtatcagct
     9061 ttttaggagt aagaagtgaa gtgcttcttc acgcattaga agaacgtgag atttatgtat
     9121 cagcaggttc tgcctgttca tctaataaac cggaagtcag cggtactttg aagggcattg
     9181 gtcttacaaa ggaatactat gaatcgacgc ttcgtttttc attctctatt tttaatacgg
     9241 tagaagaagc agatatttgt gtggaagcgt taaaagaact gttgccgatg cttcggagat
     9301 ttacaagacg ataaaacaat tagaacataa tgtactctag gaatcttttt gagcttgatt
     9361 ttgtgacaaa aaagactacg agagtacatc atataaaaaa ggagatattt atgaaattca
     9421 aagcattttt gattaaatat gcagaaattg gaatcaaggg aaacaatcgc cgtttctttg
     9481 aagatgccct tgtccgtcag atgaaatatg cattaaaacc agtaggagac ttttctatca
     9541 gaaaggaatc tggacgtatt tttgtacatg ccaatgaaga gtatgatttt gatgaggcgg
     9601 tggaaagctt aagccatgta tttggtattg caggtatttg tccaattgta gtagaagaag
     9661 ataaagattt tgaaaagatt gcggaagtcg tagaaaaata tgtagatgaa gattatgcag
     9721 ataagcattt ttctttcaaa gtacatgtaa gaagagcaga caagaagtat ccaattccgt
     9781 ctatggaagc agctgcccgt cttggagaga gattattaga gaagtttgag gacttaagtg
     9841 ttgacgtgca taatccagat gttatgctta cagtcgagat tcgtgataag gtttacattt
     9901 attccagaga gattccggga ccgggtggaa tgccggttgg tacaaacgga agagcaatgc
     9961 ttcttctttc cggtggtatc gacagcccgg tagctggtta catgatttcc aagcggggtg
    10021 taagtattga cgcaacttac ttccatgcac ctccttatac aagtgagaga gcgaaacaga
    10081 aagtagtaga tcttgcaaaa gagattgcaa aatatacagg tcctatcaca ttacatgttg
    10141 taaactttac agatattcag atggcaattt atgagaaatg tcctcatgat gaattgacaa
    10201 tcattatgcg tcgttacatg atgaagattg cagaacattt cgcaaatcag gataactgtc
    10261 tttccctcgt tacaggtgag agtatcggac aggttgccag tcagacgatg cacagtctgt
    10321 acgtaacgaa tgaagtctgt cagatgccgg tattccgtcc ttgtatcgga cttgataaga
    10381 atgaaatcgt aaaagttgca gaaaagattg gaacatatga gacatctatt ttaccatacg
    10441 aagactgctg tactattttt gtggcaaaac atccggtaac aaagccaaga ttagatgtaa
    10501 ttaagcgttc tgagagaaat cttgatgatt gtattgacga gctgatgaag acagcgattg
    10561 aaacaacaga agaaattaag attaacgctc actaaagtat taatggatga aagcattttc
    10621 aaggcagaca taagtatttt gataatgttt ataatgcttg cagataagtg cctttttaaa
    10681 aggtgggaag aagaaatatc actaaaaata tttgttttat ctgaagattc atataagaaa
    10741 aatttatctg taaagaaaga accgaggaaa gtaatatttc ctcggttgat ttcataaata
    10801 catcacaggt tatatataat atatccgtat accagaaaac ccgctcttat gtaattattc
    10861 agttactaag tatggctgta actgttccat aatctcatca agattatcag cgttatggat
    10921 atttaaatcg ataggtttag aaatatctaa actgaaaatt cccatgatag actttgcatc
    10981 aataacgtaa cgaccggaaa ctaaatcgaa ttctgcatcg aaacgattga tgacattaac
    11041 aaatgttttt accttatcga tggaatttaa agagatttta atcgttttca tatacgcgct
    11101 cctcctaaaa atgtctatat atattttaat aatatagtac ctttttagtg aaaaaaagtc
    11161 aatagatttg aggaagattt ggaaaatatt atctaaagat aaaggggaat tttttggcat
    11221 gaatctggag atgaatgagg ttagaaaaaa taggattgca ggtaggaaat aataaataac
    11281 agaaaaaacg aaaaggagaa acggaaaaag gagatttgtt tttatgagta aaagaagagc
    11341 ggcgttcctt acactgggct gtaaagtaaa tca
//
