LOCUS       c00034_gnlPro..        15157 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OAABFJBE_34.
ACCESSION   c00034_gnlPro..
VERSION     c00034_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:50:42
            Original ID  :: gnl|Prokka|OAABFJBE_34
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1385
            Orig. end    :: 16542
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15157
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[11385:14634]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13249
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..15157
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15157
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(116..1207)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:Periplasmic binding protein-like domain (Score:
                     107.3; E-value: 3.4e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_2"
                     /sec_met_domain="Peripla_BP_3 (E-value: 6e-34, bitscore:
                     107.3, seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDNGKPKYFSLMEQLRSDIMSGAIRPGEKLPSENELSQKYSLSR
                     HTVRKALGILEQDGYVEAFHGRGTYCSENMRHIKNSKNIAVVTTYISDYIFPRLIQGMD
                     NVLSESGYSIILKNTANSRQKEARCLEELLKKDIDGLIIEPSKSEMICKHRNLYQNLDK
                     FEIPYVFIQGIYSEMRDKPHILMDDAQGGYLVTKYLLELGHKKIKGFFKADDMQGLERH
                     KGYVKALQESGIAYDPDDVVWFHTEDRKVKPALMAKEMVQSGQLPDGIVCYNDQIAVQV
                     MEELEKMGVRIPDDISITGYDNSLYAQRGSGITTIAHPQEKLGEMAAELILEKINGVPE
                     EESKVERLIYPELIIRGSCRKIL"
     CDS             complement(1399..2286)
                     /locus_tag="ctg34_3"
                     /transl_table=11
                     /translation="MKKLRTFAVSMIIAAIGLLIYCAGFYIKSYEQNLAARQEYAELSQ
                     MAGVKNREGAGLLADGKKTDEDSSTKNSEKKRRKKQRRSSESKNKNCTDEIRESFGISW
                     ENLRKINSQTVAWITVPGADISYPVVQAADDEYYLKHNFRGEEDLFGCIFLEHDIKKNF
                     TDSHSILYGHNIEGNMMFANLNRYEQPEFLKKCPEIEITTPKRKFLYKIFSVEQASSQS
                     PAFEYGYKLSSPAYRRQLSILKNNSMYDTGVEPDERERMVTLITCNSRLDKEIRMAVHG
                     ICHECYGIEKAESK"
     CDS             complement(2283..6992)
                     /locus_tag="ctg34_4"
                     /transl_table=11
                     /translation="MKHNFKLKERLGALLLAMLFILQAILGLVPVCVTQAAPLTVETWD
                     SDKVVDYGYRFNMKFQPGITTYESFGCDNLDREAFSDNGKSERDTECVRVGADYKAGSA
                     GMRYNNVGKDGNGNIVDVRLILVGVENAEPRYDLRTAESIVQNKGGATFAWKDNEAYPM
                     VGFSKNSIGVFIYSVGYAKVKFQFLKHGTEETLPISGHGTIRDIDAGQGVRIPSDSSLD
                     NAYVLKNNDYLTVDGNSVSSPLGSVEPDDPRGWLNLFYNTDNFTVEFCHQFRLDKWDKS
                     REDAIAKAGSQERWAEITRNKYLDPSGNSYCPNFKGQKYCKAYAYFDFTSYCFGDVEMK
                     KAPEKRVGEANCTWEQAAAASKEKPFGIRQGQEFQYMIRAEVTPNRLKSFVVQDILEDC
                     LTIEDASKVSIVNDAGQTVTDWFDVAVEGQKVTCRAKAESLQDEAFTDNQTYTFTLKVR
                     QRPESEINISKYLAEDGYSILVPNHASMSYERTNGSGDTMDTETVWVKGVIPPELEVKK
                     NTSQYEWKTGDIIDYEILVSQIKQDVKAVNVVITDELPSCLQLLEGQYAVETSQGGENC
                     TLTGQGENGWKAECPSLKYGETITIRFKCQASADSNGQEWENIVTATADNLINPETGEQ
                     ESRKDMAEVWPNSPQLEIDKTADKYEWQAGEQVAYRIVVNNVTAGTIAKDVTITDIGLP
                     QGLVLAGGAQSMEVLGVQQQVNYPVPDKKTGQAYEARPVDSQLNADENGFSFYCSYVPY
                     SQPVTIIFHCIAQEEANGHESVNAATVKAANTDERSDDAEVYVNSGEFWIEKSADHYEW
                     QVGEQVQYNVVVENKKAGTVARNVTVWDTGMPAGLALSSAEDVSVSGIPQNITQLTAGS
                     KDVLNQLNPEFYNETSEKPVNYEFLQEGSGWRLNISDLPANTPVMISFLCTVTEAANGM
                     ESINVANVQAQNAPVSQDDAEVYVNTAVLSIEKSFQNPYLAAGDGRAENEFRVGEQVNY
                     QVTVNNLQKGSIARNLVISDLSLPEGLALDGAEDAVTVSGVPAVVQNPVAGTDDAGNQL
                     NPENYKETVEKPVSCQVTRQGTGWIVTISDLPYQTPVTVNFRCTAQESVNGMEIVNTAQ
                     AYADNAQKVKDSSKIWVNSPVLKVEKTTDKPFYKYGDIITYRIVLTQEQTGCVARNVTL
                     QDVIDTQGVRLLKDSVILMDEKGNVADADVQINDDNTFLMSTGRTLVRDSRYSICDNDK
                     GGLFEQVMYNPLDCQEQKSMIVEYQAAVIDAALAGQKVHNTAVADSSEKIPATGETETE
                     VHSPILEIVKESDKKEYASGEKGYYKLTVRQLREDVTDQNIVIEDKLETQGASIVKDSI
                     FVKKNGIELKDAKIEADDTGFVIQTGASLSDMDKIEVCYEVVFKTESTEPEKIVNTAKA
                     RGDISPEIAAQQEVYVKTKAEPTATPTPSATPKPTETPKPTETPKPTEVPKPTEQPKAT
                     PTPSVPGTCPKMTPVPTKAPLASYNGGNNGGTTSGRGGSSYANSGGYSGGYGSYQGGSM
                     AGSSKTGDVRPFKMMAVLGLIGMGLLTGGVVIYRRTVSGKRNIKGMPRK"
     CDS             complement(7195..7656)
                     /locus_tag="ctg34_5"
                     /transl_table=11
                     /translation="MNRKEFLEILRSQLAGQMQEGKAAAHIRYYEDYIQSQVRGGRSEQ
                     EVLQELGDPHLIAKTLIDTDDGSTQEDYGEYSSYGSSYGNETELPHQQEKRWKKVIDLS
                     TWHGRAVVIAAAAVIIILLILIIGVALPFFIILAIILYFLSWLKKRNDQ"
     CDS             complement(7884..8762)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_6"
                     /sec_met_domain="CN_hydrolase (E-value: 1.1e-56, bitscore:
                     181.6, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELF
                     ERPYFCQERRYEYYEYAQTAEENPAVRHFSRVATELGIVIPVSFYEKEVNNTYNSVAVL
                     DADGKNLGVYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGTIGVGICWDQWFPETAR
                     CMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPC
                     PENGMQKSALNFYGSSFITDNTGALCAELPGGEEGVLVSTFDLDALKADRLNWGLFRDR
                     RPEMYAKIVGK"
     CDS             complement(8863..10053)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_7"
                     /sec_met_domain="PAD_porph (E-value: 8.1e-129, bitscore:
                     418.9, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRLSDISDTKTLRAGFPDICRAIKEKETDMEVTEKNRTKYRMPGE
                     FEPHEGCVMIWPERPGSWNYGAREAQKAFVKVAEAIGESEKVYMLVSKAQMENAKNQLG
                     NVSGVTLLECETDDAWARDVGATMVLDEKGAVCGVDWQFNAWGGTFDGLYRNWEKDDRV
                     AAFICRTLGCPCLDARPFVLEGGSIHSDGEGTLIVTEACLLSQGRNPQMSREQIEEQLK
                     YWLGVHKIIWLPCGIYQDETNEHVDNVCAFVRPGEVVLAWTEDETDPQYAMSLADLKVL
                     EQETDAKGRKFKIHKLPIPQKPVCLTREDVDGFVFEEGEDEREAGERMAASYVNFYISN
                     GGIILPQFGDENDKRAVEILQKCFPERRIYPIDARAIIVGGGNIHCITQQIPGKNI"
     CDS             complement(10001..11122)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_8"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 2.1e-15,
                     bitscore: 46.4, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNS
                     TAQLKKFKEVCTGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENEIRTLILDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMHEDGECEVIRHFGYEDFKSRLS"
     CDS             complement(11112..12392)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_9"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 4.2e-44, bitscore:
                     141.1, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 2.1e-36,
                     bitscore: 114.6, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKE
                     KIESTTKTKIETAKVDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDSTWRAIYEKRCKEKGFTAYFDYSWQWAYDEKFKEAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             complement(12389..13249)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_10"
                     /sec_met_domain="Spermine_synth (E-value: 3.4e-54,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 5.1e-16,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             complement(13252..14709)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_11"
                     /sec_met_domain="OKR_DC_1_C (E-value: 2.8e-14, bitscore:
                     43.2, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 6.1e-127,
                     bitscore: 413.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLG
                     EKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVC
                     KAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDA
                     VAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMA
                     AVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRG
                     EESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEV
                     YDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEY
                     IAPAVVASPQQAFYAEKESLPMEQAAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYIL
                     YARDKGCSMQGMEDPKVEHLQVLKGGI"
ORIGIN
        1 taagcactca tctccgtaaa gatcctgtga acctgtacaa aaccagaact tatagtttct
       61 tcctgttttc atgataaaat tcctcctgga tttatttttt atttatttca tttgtttaca
      121 atatttttct gcatgatccc cgtatgatca gttccggata aatcagtctt tcaaccttac
      181 tttcttcttc aggaactccg ttgatcttct caagtataag ctctgctgcc atttctccca
      241 gcttttcctg cggatgagct atcgttgtga ttccgcttcc tcgctgagca tacagtgaat
      301 tgtcataacc ggtaatggaa atatcatccg gtatcctgac tcccattttc tccagttctt
      361 ccataacctg aacagcaatc tgatcattgt aacaaacgat tccatccgga agctgtccgc
      421 tctgtaccat ttcttttgcc atcagtgcag gttttacttt cctgtcctct gtatgaaacc
      481 agacaacatc atcaggatca taggcaatcc ctgactcctg taaggccttc acatatccct
      541 tgtggcgctc cagtccctgc atatcgtctg ccttaaagaa acccttgatc tttttatgtc
      601 ccagttccag cagatatttt gttacaagat agcctccctg tgcatcatcc ataagaatat
      661 gaggtttatc cctcatttct gaatagattc cctgaataaa cacatacgga atttcaaatt
      721 tatccagatt ctgataaaga tttctgtgtt tacagatcat ctcacttttg cttggttcaa
      781 tgatcagtcc atcaatatct ttcttcagaa gttcctccag acatctggcc tctttctgtc
      841 tgctgtttgc tgtgtttttc aggataatac tgtaaccgct ttctgaaagg acattatcca
      901 ttccctgtat cagtctcgga aaaatataat cagaaatata tgtggtcact accgcaatat
      961 tctttgaatt ctttatatgg cgcatattct cagagcaata agtacctctt ccgtgaaatg
     1021 cctctacata tccgtcctgc tccaggattc ccagtgcttt acgaactgta tgtctactca
     1081 gggaatattt ctgtgaaagc tcgttttctg aaggaagctt ctctcccggt cggatagctc
     1141 ctgacataat atcacttctg agctgttcca tcagtgagaa atatttcggc tttccattat
     1201 ctgtcatgtc ttcttccctc ctgtatttag gatacaactt gtacgcacgt acgaacaagt
     1261 tgttttttat gcataaatta tacaaaatat cgagagattt ttcattagtt tttcccaaaa
     1321 cacctcgagg gatagtgatg tgtgaacagt aacagttcat cctttacgaa agttaccaat
     1381 atccgattga tttcaacatc acttcgactc agctttttct ataccataac attcatggca
     1441 aatcccatgt accgccatac gtatttcttt atccagacgt gaattacagg tgatcagagt
     1501 caccattctc tccctttcat caggctctac tcctgtgtca tacatggaat tatttttcaa
     1561 tatagataat tgtctcctgt atgcaggact ggataacttg tatccatatt caaatgccgg
     1621 gctttgggaa gatgcctgtt ccacagaaaa aattttgtac agaaactttc tttttggtgt
     1681 tgtgatctca atttcaggac attttttcag aaattcaggc tgttcataac ggttcagatt
     1741 tgcaaacatc atattacctt ctatattatg cccgtaaaga atactgtggg aatctgtaaa
     1801 attctttttt atgtcatgtt ccagaaaaat acatccaaac agatcttcct ctcctctgaa
     1861 attatgtttc aggtaatatt catcatctgc cgcctgaact acaggataag aaatatcggc
     1921 tcccggaaca gtaatccagg caactgtctg agagttgatc tttcttaaat tttcccagga
     1981 aatcccgaag gattccctga tttcatctgt acagtttttg ttttttgatt cagaagatct
     2041 tctctgtttt ttcctgcgtt ttttttcact gttttttgta ctactgtctt catcagtttt
     2101 tttgccatct gccaataatc cggcaccttc tctgttcttc acccctgcca tttgggaaag
     2161 ctctgcatat tcctgccttg ctgcaagatt ctgttcataa ctttttatat agaagccggc
     2221 acaatatata agaagcccaa ttgctgctat gatcatactt actgcaaatg ttctgagttt
     2281 tttcatttcc gcggcatacc ctttatattt cttttcccgg aaacagttct tctgtagatc
     2341 accacacctc ctgtcagcag tcccattccg ataagtccaa gaacagccat cattttaaac
     2401 ggtctgacat ctcctgtttt agaacttcct gccatggaac caccctgata gcttccgtat
     2461 ccaccggaat atccacccga atttgcgtaa ctgctgcctc cgcgtccgga agttgtgcct
     2521 ccattatttc caccattgta agatgctaac ggtgctttcg tcggtacagg agtcattttc
     2581 gggcaggttc ccggtacaga tggtgttggt gtggcttttg gctgctccgt cggtttcggt
     2641 acttctgtag gttttggtgt ctctgtcggc tttggtgttt ctgttggttt cggtgttgca
     2701 gacggtgttg gtgtggcagt gggttctgct tttgttttca catatacctc ctgctgcgcc
     2761 gcaatttccg gtgaaatatc tcctcttgct ttcgctgtgt ttacaatttt ttcaggctct
     2821 gtgctttctg ttttaaatac cacttcatag cagacttcaa ttttatccat atctgacaac
     2881 gatgctcctg tctgaattac aaatcctgta tcatctgcct ctattttggc atctttcagc
     2941 tctatgccgt ttttcttcac aaaaatgctg tcttttacaa tagaagcccc ttgggtttcc
     3001 agtttatctt cgataacaat attctgatct gtgacatcct cacgcagttg tcttactgtc
     3061 agcttatagt atcctttctc accggacgca tactctttct tatctgattc cttcacaatt
     3121 tccagaatcg gactgtgtac ctctgtctct gtttccccgg ttgcaggtat cttttcactg
     3181 ctgtctgcaa ctgcagtatt gtgcactttc tgtcctgcca gggctgcatc aatcactgct
     3241 gcctgatatt ccacgatcat acttttctgt tcctgacagt ccagaggatt atacattacc
     3301 tgctcaaaaa gaccgccttt atcattatcg cagatactat atctgctgtc cctgaccagt
     3361 gtcctgcctg ttgacatcag gaaagtatta tcatcattga tctgtacatc agcatctgct
     3421 acatttcctt tctcatccat cagaatcacc gaatccttca gaagacgtac tccctgagta
     3481 tcgatcacat cctgcaaagt aacattacgc gccacacatc cggtctgctc ctgtgtcagg
     3541 acaatgcggt atgtaataat atcaccatat ttgtaaaatg gtttgtccgt cgtcttctct
     3601 actttaagaa caggcgagtt cacccagatt tttgaggagt cctttacttt ctgtgcatta
     3661 tctgcatacg cctgtgctgt atttacaatc tccatcccat ttacgctttc ctgcgcagta
     3721 cagcggaaat taacagtcac aggtgtctga tacggaagat ctgaaatcgt cacgatccat
     3781 ccggttccct ggcgtgtaac ctgacagctg accggttttt ccactgtttc tttataattt
     3841 tccggattca gctgatttcc tgcatcatca gttcctgcca ccggattctg aacaacagcc
     3901 ggaacaccgc ttacagtaac agcatcttca gctccgtcca gagccagccc ttcaggaagg
     3961 gaaagatcac tgatcacaag atttcttgcg atagatccct tctgaagatt attaaccgta
     4021 acctgataat tcacctgttc tcctacccga aattcatttt ccgcacgtcc gtccccggct
     4081 gccagatatg gattctgaaa acttttctca atagaaagaa ctgctgtatt tacatacact
     4141 tctgcgtcat cctgcgaaac aggggcattc tgcgcctgca cattggcaac attaatgctt
     4201 tccattccat ttgccgcttc cgtaactgtg caaaggaaag aaatcataac cggagtattt
     4261 gccggaagat ctgaaatgtt cagtctccat ccgcttccct cctgaagaaa ttcataattc
     4321 actggtttct ctgatgtctc attataaaat tccggattga gctggttcaa aacatctttg
     4381 ctccctgctg tcagctgcgt aatattctgt gggattccgc ttaccgatac atcctctgcc
     4441 gatgaaagtg caagtcctgc tggcataccg gtatcccaga cagttacgtt ccgggccact
     4501 gtacctgctt ttttattctc caccaccaca ttgtactgta cctgttctcc gacctgccat
     4561 tcataatgat ctgcagattt ctcaatccag aattctcctg aatttacata tacttctgca
     4621 tcatcagatc tctcatctgt attagcagct tttacagttg ctgcatttac gctttcgtgt
     4681 ccatttgcct cttcctgtgc gatacaatgg aaaataatcg ttacaggctg actgtatggc
     4741 acataagaac aataaaagga aaatccgttc tcatctgcat tcaactgaga atccacaggt
     4801 ctcgcttcat atgcctgtcc tgttttctta tccggtacgg gatagtttac ctgttgctga
     4861 actcccagta cttccatgct ctgtgcacca cctgccagaa ccagtccctg cggcagacca
     4921 atatcagtaa tagttacatc ttttgcgatt gttcctgccg ttacattatt caccacgatc
     4981 cggtaagcta cctgctctcc tgcctgccat tcatatttgt ctgctgtttt atcaatttca
     5041 agctgtggac tgttcggcca tacttctgcc atatcctttc tggattcctg ttctcccgtc
     5101 tcaggattga tcagattatc cgctgttgca gtcacaatat tttcccattc ctgtccattg
     5161 gaatccgcag atgcctgaca tttaaaacgg attgtgatcg tctccccata cttcagggac
     5221 ggacactctg ctttccatcc attttctccc tgtccggtaa gcgtacagtt ctcacctccc
     5281 tgacttgtct ctacagcata ctgcccttcc agaagctgca gacatgatgg aagctcgtct
     5341 gtaataacaa catttactgc ttttacatcc tgttttatct gagaaaccag aatctcataa
     5401 tctatgatat ctcccgtttt ccattcatac tgagaagtat ttttctttac ttccagttcc
     5461 ggtggaatca caccctttac ccacactgtt tccgtatcca ttgtatctcc gcttccgttt
     5521 gtacgttcat aactcatgga tgcatggttt ggtacaagaa tactgtatcc atcctctgca
     5581 aggtattttg aaatgttaat ttctgattcc ggtctctggc gtacttttaa agtaaatgtg
     5641 taagtctgat tatctgtaaa tgcttcatcc tgaaggctct ctgctttggc cctgcaggtc
     5701 actttctgtc cttcaacagc aacatcaaac cagtctgtca ctgtctgccc tgcatcattc
     5761 acaatactga cttttgatgc atcctctata gtaagacaat cctcaagtat atcctgtacc
     5821 acaaaggatt tcagtctatt gggtgtcacc tccgcccgga tcatatactg aaattcctgt
     5881 ccctgacgaa tgccaaaagg tttttctttt gatgcggcag ctgcctgttc ccatgtacag
     5941 tttgcctctc ccacacgttt ctcaggcgct tttttcatct caacatcacc gaaacaatag
     6001 gatgtaaaat caaaatatgc atatgctttg cagtatttct gtcctttaaa gttcggacaa
     6061 taactgttgc ctgatggatc cagatattta tttcttgtaa tctctgccca tctttcctga
     6121 gaaccggctt ttgcaatggc atcttcacga cttttatccc atttatccag tctgaactga
     6181 tgacagaatt ctaccgtaaa attatctgta ttataaaaaa gattcagcca tcctctcgga
     6241 tcatccggct caacggaacc aaggggtgag cttacagaat ttccatctac cgtcagataa
     6301 tcattgtttt tcagaacata tgcattatcc agactgctgt ctgacggaat acggactccc
     6361 tgtcccgcat caatatcacg tatggttcca tggccactga tcggcagtgt ttcttctgtt
     6421 ccatgcttca gaaactgaaa cttaaccttt gcgtatccta cagaataaat aaatacaccg
     6481 atactgtttt tggaaaagcc aaccattgga taagcttcat tatctttcca tgcaaacgta
     6541 gctccgcctt tattctgaac aatcgattct gcagtgcgca gatcataacg gggttctgca
     6601 ttctctactc ccacaagaat gagtctgaca tcaacaatat ttccatttcc atcttttcct
     6661 acattgttat aacgcatccc tgcgcttccg gctttatagt ccgctcctac acgaacacac
     6721 tctgtatcac gttcgctttt tccattgtct gaaaaagctt ccctgtccag attatcacac
     6781 ccaaaagatt catatgtggt aattccgggc tgaaacttca tgttaaagcg ataaccataa
     6841 tctaccacct tgtcactgtc ccatgtttct acagttaacg gtgccgcctg agttacgcag
     6901 acaggcacaa gccccagaat tgcctgcaga ataaaaagca ttgcaagcag caaagctcca
     6961 aggcgttctt tcagtttgaa attgtgtttc attttccgtc tcctttccga acaaaaaata
     7021 taaaaatgaa tgtgggattt ttccctgcac ctggcaggat taaagaatag aaataagttg
     7081 agattgtatg attataaata ttcaagggga attaatatcg tgaaacaaga acgtttacac
     7141 ttaagatttt aagattctgc gcagggtttc ttttctgaaa ccctgcatag attttcattg
     7201 atcatttctt ttcttcagcc atgaaagaaa ataaagaata attgcaagaa ttataaaaaa
     7261 cggaagcgca actccgatta tcagtatcag taaaataatt ataacagccg ctgctgcaat
     7321 aacaacagcc ctgccatgcc aggtagaaag atcgattact tttttccatc ttttctcctg
     7381 ctgatgagga agctctgtct cattgccata actgcttccg taagaagaat actctccgta
     7441 atcttcctgt gtacttccat catctgtatc gatcagagtt tttgctatca gatgtggatc
     7501 tcccagttcc tgcagtacct cctgctctga acgtccgcca cgtacctgag actgtatata
     7561 atcttcataa tacctgatat gtgctgctgc tttgccctcc tgcatctgac cggcaagctg
     7621 gcttctcagg atttccaaaa attcttttct gttcatcttc tacactccat tttgccagaa
     7681 atacatatca aaactctact gctctctccg ttatcagtaa cgttcgtact cttattttac
     7741 catatatacc gcaggtagca actaatataa tcataaactt tttatgaaat tcttataaac
     7801 tcagttactg ttcactccgt tctcagtaac tgagccaaaa ttcattccag attgcctgcg
     7861 gcaatggaat tttggcttgt atgtcatttc ccgacaattt ttgcatacat ttcaggtctg
     7921 cggtctctga aaagtcccca gttcagtctg tctgccttta atgcatccag gtcaaaagtg
     7981 cttacaagca ccccctcttc ccctccgggc agttctgcac agagagcacc tgtgttgtct
     8041 gtgataaaag aagagccgta aaaattaaga gcagatttct gcattccgtt ttccggacat
     8101 ggctccactg tttcctcacc gattctgttg gcagcgatca cagggatcag gttggaggca
     8161 gcgtgtccct gcatacatct tctccagtgt tccatgctgt cacattccag aatgggttca
     8221 cttccgatgg cagtgggata aaagagaagc tctgcgccct gcagtgccat acatcttgcc
     8281 gtttccggga accactgatc ccagcagatt ccaactccaa tggttccaaa tctggtatca
     8341 aaaaccttaa agccggtatc tcccggtgtg aaatagaatt tttcctgata ataatggtca
     8401 tccggaatat gtgttttccg gtaaacgccg agattcttcc catctgcatc cagaaccgca
     8461 acgctgttat aggtattatt gacctctttt tcataaaaac tgaccgggat cacaatcccc
     8521 agctctgtcg ctaccctgct gaaatgacgc actgcagggt tttcctctgc agtctgcgca
     8581 tattcataat actcatatct gcgctcctgg cagaaatagg gccgttcaaa aagctccgga
     8641 agaagaacaa tctcagctcc ctttgctgct gcctgacgca ccagttcctc tgcatgggca
     8701 atatttttct ccacactttt actgcatttc atctgaactg ctgccactgt tacatttctc
     8761 atcctgtctg ttcctcctgc tcctgtttac ataagtaagt tttttcataa ctttcaggta
     8821 taaccctcaa acacatgact ctcaaagttt tctgcatcag ggtcagatat tcttcccggg
     8881 aatctgctgg gtgatacagt gaatatttcc accgccaaca atgatggctc tggcatcaat
     8941 gggataaatc cttctctctg gaaaacactt ctgcagaatc tccactgccc ttttgtcatt
     9001 ttcatcccca aactgtggaa ggatgatccc tccattggaa atataaaaat tcacgtaact
     9061 ggcggccatc cgttctcctg cttcccgttc gtcttctccc tcttcaaaca caaagccatc
     9121 cacatcttcc cgtgtaaggc agaccggttt ctgaggaatc ggaagcttat gaatcttaaa
     9181 ttttctgcct tttgcatctg tttcctgttc cagcaccttc agatcagcca gagacatggc
     9241 atactgcgga tctgtctcat cctctgtcca tgcaagcaca acctctccgg gccttacaaa
     9301 agcgcacacg ttatccacat gctcattggt ttcatcctga tagattccac atggaagcca
     9361 gataatcttg tggacaccga gccagtactt caactgttcc tctatctgtt ccctgctcat
     9421 ctgaggattg cgtccctgac tcagaagaca ggcctctgta acgatcagag tcccctctcc
     9481 gtcagaatgg atggaaccgc cctccagcac aaaaggtctg gcatccagac atggacaacc
     9541 gagagtcctg cagataaagg cagccaccct gtcatccttt tcccagttcc ggtaaagccc
     9601 gtcaaaggta cctccccagg cattaaactg ccagtcaact ccacagaccg cccctttctc
     9661 atccagaacc atggttgctc ccacatctct ggcccaggcg tcatctgtct cacattccag
     9721 caaagtcaca ccggaaacat tcccaagctg attctttgca ttctccatct gagctttgga
     9781 aaccagcata tacacctttt cgctctctcc aatagcctct gcaactttca caaatgcttt
     9841 ctgtgcttcc cttgccccat aattccagga accgggacgt tccggccaga tcatcacaca
     9901 tccctcatga ggctcaaatt ctccgggcat acgatatttt gttctgttct tctctgtaac
     9961 ttccatgtct gtctcctttt ctttgatagc ccggcagata tcaggaaagc cggctcttaa
    10021 agtcttcgta tccgaaatgt ctgataacct cacactctcc gtcctcatgc ataaccgcaa
    10081 tatccggcag cggcataccg ttaaatgtat tattcttcac catagaataa atcgccatat
    10141 ccataaaata tagcttgtcc ccgatccgga tctctctgtc aaaggaataa tctccgatta
    10201 catctcctgc caggcaggtg caagaagata agcggtaggt atatgccttc tcccctgctt
    10261 ccccgctgtc cttaagaggc ggacgatagg gcatctccag cacatccggc atatggcagg
    10321 ctgcagaagc atccaaaatc agcgttctga tctcattttc cacaatgtcc ataacctctg
    10381 tcaccagata tccggcattc agggcaacag cctccccggg ctccagataa atatccagat
    10441 cataggtttc cttcatatgc tgaatacatt tttccaggag ctttacatca taatcctctc
    10501 tggtaatatg atgtccgccg cccatattca gccaggaaac ctcagacaga aattctccaa
    10561 acttctcctc taccgcctgc aatgttttct ccaggtcatc cgcattctgt tcgcagagcg
    10621 tatgaaaatg cagtccgtcg atccatttca gacattcccc gtcaaagttc tctctggtaa
    10681 cccccagcct tgaacccggc gcacagggat catagatcgc atgatccccc tgagtggagc
    10741 attccggatt aatacggagt cccagactgg ctccggtaca cacttcttta aatttcttca
    10801 gctgtgctgt ggaattaaag ataatatggt cacagatccg atccagttcc tctatatctt
    10861 ctgtacggta agcaggggaa aaaacatgat tctctttccc catctcttca tatccaagcc
    10921 ttgcctcaaa cagaccgctg gcagtggtac ctgccagata ttttccgatc atgggataca
    10981 gagcaaagcc ggaaaacgct ttctgcgcca gaaggatctt acacccggta tcctcctgga
    11041 cttttttcaa aatctccaga ttctcccgca tcttcttctc atcgatcaca tagcagggag
    11101 tttgcagttg atcaatcttc attggctttc cagaccttta ccagttcagg atcttcgcag
    11161 actttccatg gaagtcccca tttgttcagt gcttccatat atggatccgg atcaaattct
    11221 tccacattaa atacacccgg cttcttccac tgtccggtca ctaccatcat ggaaccgatc
    11281 atagccggaa cacctgttgt ataggagatt gcctgggatt ccacctcttt atagcattcc
    11341 tgatgatcac atacattata aatataaata cttttctctt ttccgtcctt aacacctgtg
    11401 aaaatacagc cgatatttgt tttacccact gttctcggac ccagagatgc aggatccggc
    11461 agaagagctt tcaaaaactg gatcggcaca atctcctgtc cattaaattc cacaggtgcg
    11521 gtggaaagca ttcctacatt ttccagacat ttcatatgtg tcagatagct ctgtccgaat
    11581 gtcataaaga aacggatcct ctgtactccc ggaatatttt ttgccagtga ttcaatctct
    11641 tcatgatgaa gaagatacat atccttcttt cctacctcag ggaaatcgta gacagattta
    11701 aattccatag gctctgtttc tacccaatgt ccgtcttccc agtaggaacc atttgcggaa
    11761 acctctcgaa gattgatctc cggattaaag tttgtggcaa aaggatatcc atgatcaccg
    11821 ccattacagt ccagaatatc aatggtatgg atttcatcaa aataatgctt cagggcatag
    11881 gcactgaata cactggtaac acccggatca aaaccggttc ccagaagagc agtcagtcct
    11941 gcttccttaa atttctcatc ataagcccac tgccaggaat aatcgaaata tgcagtaaag
    12001 cctttttctt tacatctctt ttcgtagatt gcacgccatg tggaatcttc tgtatcctct
    12061 gcttcataat tggcagtatc aatataatcc gcaccggctt ccagacatgc atccatgatg
    12121 gtaagatcct gatatggaag tgccacattc aggacagcat ccggcttata ggctctgatc
    12181 aattctgcga cctctgctgc attatccgca tctacctttg ctgtctcaat ttttgtcttc
    12241 gttgtacttt caatcttctc tttgagtgca tcgcattttt cctttgtcct gcttgcgatc
    12301 ataatctctg taaaaacatc gctgttctga cagcatttgc gaattgccac tgaagctacc
    12361 ccaccacatc cgattaccaa taatctgctc ataaactgtt ttcctcctct tccagtaaat
    12421 cttctacata ttttggaagc ataaatgctc ctctgtgaag atttgttgta taataccatg
    12481 tttctatatt aagattatca aacctctccg gcctgaaatc ttccagtgga tgatatttct
    12541 ttgatgcaaa tccaaaaagc cagtatcccg agggacaggt agggatatgt gcctgataaa
    12601 ccctgctcac cggaaatgac cggaaaacct ttctgtgcat ctttctgcat tccacctcat
    12661 cctcatcata aaaaggactt ccatgctgat aaaccatgat tccgtcatct ctgagagcct
    12721 tataacagct tccgtagaat tcctttgtaa aaagtccctc tgtatgtccc agcggatctg
    12781 tggaatcatt gatgatcagg tcatatctgg cctttttatt ccgcaggaac cgaaggccgt
    12841 cttcataata aatgttgact ctctcatcct tcaatccctg ggcaatatcc ggaaacatct
    12901 ccgcacatac atccacaaac attttatcgg attccaccac atcaatgctc tcaatctgtg
    12961 gataatggat cagttctctg gcaactccac cgtcaccgcc gccgatgatc agaacatttt
    13021 ttacattggg atgtactgtc attggcacat gcgtgaccat ttcatcataa ataaattcat
    13081 ctttatcaga gaatacgatc tcaccgtcca gagccacaaa tcttccaaat tcttcagact
    13141 caaacacatc gattctctga aattcacttt cccctgaaaa taactgtcgg ttaatccgga
    13201 cagaaagctt tacatttcct gtatggaact cagaatacca taattccatg atcagatacc
    13261 ccctttcagg acctgaagat gttctacctt cggatcctcc attccctgca tggaacagcc
    13321 tttgtctctt gcataaagaa tgtattctac aatttcctgt gtcaccattt ctccaggagc
    13381 aagaatcggg attcccggag gataacacat aacaaattca ccgctgatcc tgcctgccgc
    13441 ctgttccatg ggcagagatt ctttctccgc ataaaatgcc tgctgtggag acgccaccac
    13501 tgcaggtgcg atatattccc cggaaagcat acctgtgctg tccttcttat acagacgttc
    13561 aatatcagcc aatgccccta ccagcctctc aatatcctga agcctgtctc caatggaaat
    13621 gtaagccaga atattacaga tatctccaaa ctcgatctga atatcatatt catctctgag
    13681 aagatcataa acttcaatac ctgccagccc atttcccagt gtataaatgg agagttttgt
    13741 aacatcaaaa tcaaaaacac tggttccatt gatcagatcc ataccatatg cataataacc
    13801 gccgatctca ttgatctcct ctctggcata ctgcgccatc cctgcaacct tttcaaagga
    13861 ttcctctccc ctgagtgcca gatttcttct ggagatatcc agactggaca acagaagata
    13921 agaagcgctt gtggtctgag tcaaattgat gatctggcgc actttctctg cattcatact
    13981 cttattcaaa agcagcagcg aactctgtgt cagacttccg ccggatttgt gcatggaaac
    14041 tgccgccatg tcagcacctg ccgccattcc ggacacagga aggtttctgc cgaaataaag
    14101 atgggttcca tgagcctcat ctgccagcac cttcattcct cttgcatgag ccttctttac
    14161 gatagtccgc agatccgaac agattccata ataggtaggg ttatttacaa gaactgccac
    14221 cgcatccgga ttctcatcca tagccttctc cacctgactg acttccatgc caagggaaat
    14281 gcccagctgc gcattcacct ccgggtttac ataaaccgga attgcaccgc acagtaccag
    14341 ggcattgatg gcacttttat gtacatttcg cggcagaatg atcttatccc ctgccttgca
    14401 gacagacagg atcatgctct gcactgcaga tgtggttcct cctaccataa ggaatgcatg
    14461 cgctgcgcca aaagcatctg ctgcaagctc ctccgcttct ctgatcaccg aaaccgggtg
    14521 gcagagattg tccagcggct tcatagaatt aacatccagc cccacacatt tctctcccag
    14581 caactgtgca agctctggat ttcctcttcc tcttttatgt cccggcacat caaagggaac
    14641 gactctcttc tttcggaaac gttccagtgc ttcatatatg ggcgcatgct gttgtctttc
    14701 ataatccatt tgacatgttc ctcttttcct gtcgtcatgt accggcaaat acagttctat
    14761 cattcagcaa ttgtatactg cctcaaaccg gcacaatgat tcaattattt ctctatatat
    14821 tcaagtcgaa cgcatgtgag acacatcctc gcaaagcgtt tatctccaac catatccttt
    14881 atatttgcta tatctgcaca aaaaaagaag cagataagtt cattcaccat ctgcttctct
    14941 catgatctat agaatttctc aggctctgtc tctttatata ctgaccggat ttcccgtata
    15001 aatccgtctg tatcctgtgc ctgttcccgt attctgaaat attcatgact gctgtcgtct
    15061 tcaatcgctg gcaaatatat gctatgctct tattgaccgt ttcacaagat gatgtgtgct
    15121 tacgcactga ttattataaa gtaatcaact tataaaa
//
