LOCUS       gnlProkkaLPIPGHJE_12   21589 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LPIPGHJE_12.
ACCESSION   gnlProkkaLPIPGHJE_12
VERSION     gnlProkkaLPIPGHJE_12
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 21:48:15
            Original ID  :: gnl|Prokka|LPIPGHJE_12
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 113
            Orig. end    :: 21702
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21589
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11589]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11589
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..21589
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21589
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             617..1567
                     /locus_tag="ctg12_2"
                     /transl_table=11
                     /translation="MQKDYETFVEKLEIGIYEATGIPRENISFEKEGGRFAPVGDRLLV
                     KFAEHDDAWEVCGLYTQELFKSYQNGSPFEEIIKEITDDLNRIKKADIYEKTRVIRDYE
                     KTKPRLFIRLLNADKYSADLQDAVYKTLGDIALVLYMKVTEYEGCATSTKIRQGMLEQW
                     GKECDEVFQEAILNTYFMSPPRIYRWEQMIFNPEYEGESFMNLGDKCELKKDAMGNCLS
                     TTKKTNGAVAVFLPGVAEQLAYMLDSDFYMVFTSVHEVMIHNDKFVEPEDLQCVLRDTI
                     REATPKEDYLTSRIYQYNRETHKFICVTPLEKDEK"
     CDS             complement(1642..2436)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 168.4; E-value:
                     3.5e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_3"
                     /transl_table=11
                     /translation="MLELKNIYKTFNPGTINEKRALNGLNLKLNEGDFVTVIGGNGAGK
                     STMLNAVAGTWPVDEGQILIDNIDVTKLSEHKRATYLGRVFQDPMTGTAATMGIEENLA
                     LAKRRGKSRLLRSGITKAEREEYKELLKILGLGLEDRLTSKVGLLSGGQRQALTLLMAT
                     LQKPKLLLLDEHTAALDPKTAAKVLEITDMIVNRDHLTTLMITHNMKDAIAHGNRLIMM
                     MEGKIILDIQGEEKKKLTVKNLLDQFEKASGEEFSNDSALLG"
     CDS             complement(2439..3356)
                     /gene_functions="transport (smcogs)
                     SMCOG1113:inner-membrane translocator (Score: 66.8;
                     E-value: 2.7e-20)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_4"
                     /transl_table=11
                     /translation="MQIITLITALPGAVAQGLIWGIMAIGVYITFRILDIADLTVDGTM
                     CTGGAVCIMMMLSGHNVWISMLAATLAGMLAGLATGIFHTFMGIPAILAGILTQLSLYS
                     VNLKIMGKANQAINVDKYNLLVSLRHIKNASLSKNTIFIVAVMCILLIAILYWFFGTEL
                     GCSLRATGCNPNMSRAQGINTNRNKVLGLMISNGLVGLSSALLAQYQGFADVNMGRGSI
                     VIGLAAVIIGEAIFGRIFRNFALRLLAVIFGSILYYLVLQIVIWMGIDTDLLKMLSAIV
                     VALFLAFPYWKGKYFNKPAKRGGK"
     CDS             complement(3507..4493)
                     /locus_tag="ctg12_5"
                     /transl_table=11
                     /translation="MKRKALAITLAAAMAMGTCAVTASAADGDKYTIGICQLVQHEALD
                     AATQGFKDEVTKELGEDAVTFDEQNAQGDSNTCSTIINSFVSNNVDLILANATPALQAA
                     AAGTSDIPILGTSVTEYGVALGLDDFDGTVGGNISGTADLAPLDQQAAMLNELFPDAKN
                     VGLLYCSAEANSQYQVDTVKAELEKLGYTCEYYAFSDSNDLSSVATTATDASDVIYVPT
                     DNTVASNTEIINNICLPAKVPVITGEEGICSGCGVATLSISYYDLGVTTGKMAVKILKD
                     GEDISTMPIEYAPNFTKEYNKDICEELGIEVPDDYVAIGEAAEETAK"
     CDS             4757..5521
                     /locus_tag="ctg12_6"
                     /transl_table=11
                     /translation="MAYSIMLDAGHGGQDPGAVYKGRQEKNDNLKLALAVGEILKNKGI
                     DISYTRTGDVYQTPFEKAQLANQAGVDYFISFHRNSSPKENQYNGAEVLIYDKSGIKYQ
                     MAENILGALGEVGFREIGVKERPGLVVLRRTRMPALLIETGFINSEEDNKLFDNKFSDI
                     AQGIADAILGSLDEETVQEPLYYRVQTGAFRKKENADRMLYQLLEKGYPSFMLHENGLY
                     KVQTGAYQQIGNAVNMEQRLRDDGYSTVIVTK"
     CDS             5792..6391
                     /locus_tag="ctg12_7"
                     /transl_table=11
                     /translation="MNDVYEKFLKSSEEFIFAENKPEKSDIIFVPGNGYPQMAEKAAEL
                     FKKGMADWILPSGKYSVVNGKFSGVLEKSNVYDKEYGTEWEFLRDVLIKNGVPDQKILK
                     EDQATFTYENAIYSRQVTDHAELEIERAILCCKSYHARRCLMYYQLLYPKTEFYVVPVN
                     ADGITRENWRKNEEGIDAVTGELSRIVKQFSLMLER"
     CDS             complement(6395..7678)
                     /gene_functions="other (smcogs) SMCOG1273:hypothetical
                     protein (Score: 354.6; E-value: 1.3e-107)"
                     /gene_kind="other"
                     /locus_tag="ctg12_8"
                     /transl_table=11
                     /translation="MDSSIAFQAVAILILIALSSFFSSAETAMTTVNKIRIQSLAEQGN
                     KRAVILEKIISNSPKMLSTVLIGNNIVNMSVSSLMTTLTIKILGNAYVGITTGILTLLI
                     LIFGEITPKNLATIHAEKLSLAYSRIIYGLMILLTPVVFIVNKITEGVLVILHVNPDEK
                     ANAMTEHELRTLVNVGEKDGVIENEEKQMIYNVFDFGDSTAKDVMIPRIDMTFIDINFS
                     YDELMAVFSEDMHTRFPVYEDNTDNVIGIINMKDLLVYPKDKPFSIRNILREPYFTYEY
                     KATADLMIEMRKASVNLAIVLDEYGATAGLVTLEDLLEEIVGEIRDEYDEDEVEDIKEI
                     QPEREYVVQGSAKLDDINEALHINLESEDYDSIGGYIIEQLDCLPKEGQSVTLESGIRL
                     VVDRLDKNRIELVHIWLPEKKTETEEQP"
     CDS             8022..9527
                     /locus_tag="ctg12_9"
                     /transl_table=11
                     /translation="MSNNIRIRKKKLKGTGIFAAAALTAALIAGNNIPGVTRQVSAAES
                     QENTVSSLIPDNITLDKPVELADVELPATEYGTFEWADGSFVPAQRVQSCEVLLIPAEG
                     QDLSHVDGWDPESGAVVGYINVIVNSITDGDNVDKTEGSGKTDPTENADPTETPETSSE
                     KPAADENADTDNKEDKESKSDQDNKTDTDNEESKIEEDKTDNKNNKDNNSNADKTDKDT
                     ETTGKLEPADDMTQDKEDTKKDDEDGADDNIFDNPVLPDDKDDRPTDAEDSLSDEEKEE
                     RAALNHTCDGITVSGVNLPWYVQFRVSSGDSYQFTNESDAMIFQSYEFELWDLKNNTEY
                     EIPNGDYISVTVPVKSGYQYTIEHLLDNGATETIIPSVENGIMVFSTHSFSPFGIAGSR
                     QLVGPDAGNDTDDTDAVTPAPASSDSQSSDSGKNNTVSMNDSSDSNNGSSSDQNDNSTE
                     NKAVKNNNTVNTGDTTSIMPFVILFVAAAVIAGVVVFIKKRKK"
     CDS             9577..9927
                     /locus_tag="ctg12_10"
                     /transl_table=11
                     /translation="MKVRAILKSLLFAYALTGVALLLLALVLFAFDLGETAVDAGIIII
                     YVLACFMGGFMAGKIVRKDKYLWGVITGLAYYVLLLTVSIMAKGGWDMSAAHAVTTFFM
                     CTGGGTLGGMLS"
     CDS             10001..10141
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_11"
                     /sec_met_domain="TIGR03973 (E-value: 1.3e-27, bitscore:
                     87.3, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1.7e-27, bitscore: 87.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKNLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEQ
                     K"
     CDS             10222..11589
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_12"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 6.5e-29,
                     bitscore: 92.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.5e-16, bitscore: 51.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.9e-14, bitscore: 45.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 9.9e-20, bitscore:
                     62.7, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIHRYKSNGFNIVLDINSGCIHLVDEVTYEVLPYLEEGLGTEA
                     IAEKLENKYNREDIETSVRECNKLKEDGMLFTKDVYENVIEEFSNNRQTVVKALCLHIA
                     HDCNLACRYCFAEEGEYHGRRALMSYEVGKKALDFLIANSGSRKNLEVDFFGGEPLMNW
                     QVVKDLVKYGREQEKLHNKKFRFTLTTNGVLLNDEVMEFCNKEMGNVVLSVDGRKEVHD
                     YMRPFRKGAGSYDLIMPKFQKFAESRNQDKYYVRGTFTHHNLDFSKDVLHLADLGFKQI
                     SVEPVVAADTEEYAIREEDIPQIMEEYDTLAKEMIKREKEGKGFNFFHFMIDLTGGPCV
                     YKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEQYLMGNVDEGITKPEIQKEFGGCNVYT
                     KKDCKDCFARFYCSGGCAANAFHFQGDIKGNYEIGCELQRKRVECAIMIKAALACD"
     CDS             11701..14109
                     /locus_tag="ctg12_13"
                     /transl_table=11
                     /translation="MKKSKGIVVLLLTLILTVFFCFTAAVGIGPTGTGAAKHINTGLDL
                     AGGVSITYQAKESNPTSEEMSDTIYKLQKRVEQYSTEAQVYQEGSDRITVEIPGVTDAD
                     TILNDLGKPGSLYFITKEDADGNQNFTTGQDGYVLSRTMDEIKESGSVVLEGSDVADAQ
                     GGAIQNQNTSAKEYVVSLTLTSDGENSGKTKFAEATKNNVGKQIAIVYDNNIISAPNVN
                     EEISGGKAQISGMSDLEEAQNLASYIRIGSLGLELEELRSSVVAAQLGEEAISTSVLAG
                     AIGLIIVIIFMIIAYRVPGVVAGIALILYTSLMLITLNAFDITLTLPGIAGIILGIGMA
                     VDANVIIYARIREEIGAGVSVRNSIKSGFSKAFSAIFDGNITTLIAAFVLMWLGSGTVK
                     GFAYTLALGIVISMFTALVVSRLIVNALYAVGVRDPKFYGSAKERKAVDFLGKKKVFFA
                     ISIILILCGPAAMFANSHAGNKALNYSLEFSGGTSTTVTFNEDMDIKTIDSEVTPVVEE
                     VTGDKNVQPTKVVGTNQVVIKTRSLNQSEREALQSALVEKFGVDDSTISTESISSTVSS
                     EMRRDAIVAVIVATICMLLYIWFRFKDIRFASSAVLALLHDVLVVLAFYAIARVSVGNT
                     FIACMLTIVGYSINATIVIFDRIRENLHSGSREKLAEIVNTSITQTLTRSIYTSFTTFV
                     MVAVLYIMGVSSIREFAAPLMVGVLVGAYSSVCITGALWYVMKKKFAGKGQPAIAAASA
                     SAKSSSKPKKARDVSQKDPTQPKKKNRKRVAERLAAEEAAKKQQNDDAE"
     CDS             14191..15903
                     /locus_tag="ctg12_14"
                     /transl_table=11
                     /translation="MEKWVIAAKRADFNQIGQQFHIDPVIARLIRNRDVIGEDKIREYL
                     SGTVQELPSPWLMKDMEKAVDILEKKISQKAKVRIIGDYDIDGVTSTYILMKGLARIGA
                     DVDTYIPDRVADGYGIHAHLIERAETDRIDTIVTCDNGIAAAAEIQMAKDKGMTVIITD
                     HHEVPYREEKGERQMVLPPADAILNPKQYDCPYPNKNLCGAVVAFKYIAALYERFGVPA
                     EELEDYYELAAIATVGDVMDLQGENRILVKEGLYRLRNTKNQGLQELIRANSLEDAKIT
                     AYHIGFVLGPCINASGRLDTAARSLALLNAKTKEEAARLAGDLTALNQSRKALTEKGKE
                     EAIRIIETTELKNDRVLVVYLPDCHESLAGIIAGRIREKYHRPAFVLTGGETSAKGSGR
                     SIESYSMYEELVKCADLMIQFGGHPMAAGLSIEEKNIEEFRRRLNVNCTLTDEELRPKI
                     VIDVPMPVSYITKELVEQISLLEPFGKGNTKPVFAQKNLRVLDYSIIGKNKNVLKLKLL
                     DPQGISVEGIYFGEAEDFVNFIREKDSISVTYYPEINRFRGRESLQIIIQNYC"
     CDS             16051..16575
                     /locus_tag="ctg12_15"
                     /transl_table=11
                     /translation="MKKIEDYVLSIPDFPEPGIIFRDITSVLQDADGLQLAIDSMQDCL
                     KDIDVDVIAGTESRGFIFGVPIAYNLHKPFVPIRKKGKLPRETVSVSYDLEYGSAEIEM
                     HKDSIKPGQKVVIVDDLIATGGTIEAAIKLVEQLGGEVVKVVFLMELAGLKGRERLNGY
                     DVASVICYDGK"
     CDS             16613..18943
                     /locus_tag="ctg12_16"
                     /transl_table=11
                     /translation="MTEITKSTEAKKDEMQVEKEKLESVKRADAAVKTMHDFTSPEVLY
                     KELINSVLKYHPSTDISMIEKAYKVASEAHEGQKRKSGEPYIIHPLCVAIILADLELDK
                     ETIVAGLLHDAVEDTWMTYEEVEKEFGSEVALLVDGVTKLGQLSYSADKVEVQAENLRK
                     MFLAMAKDIRVILIKLADRLHNMRTLQYMRPEKQQEKARETMDIYAPIAMRLGISKIKV
                     ELDDLSLKYLKPDVYYDLVHKVALRKSEREQFVGAIVKEVKKHMDDANIKAQVDGRVKH
                     FFSIYKKMVNQDKTIDQIYDLFAVRILVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMP
                     KPNMYQSLHTTLIGPNGQPFEIQIRTYEMHRTAEYGIAAHWKYKESSDGKAPVGKSEEE
                     KLNWLRQILEWQRDMSDNKEFMSLLKNDLDLFADSVYCFTPQGDVKTLPSGSTPVDFAY
                     SVHSAVGNKMVGARVNGKLVPIEYEIKNGDRIEIITSQNSQGPSRDWLKLVKSTQAKNK
                     INQWFKKELKEDNILKGKEMLAQYARAKGFKITNYTKTQYLEAVLRKYGFRDWDSVLAA
                     IGHGGLKEGQVFNKLVEAYDKENKKNLTDEQVLEAASETQEKLHIAKSKSGIVVKGIHD
                     VAVRFSKCCNPIPGDEIVGFVTRGRGITIHRTDCVNVLNMSETDRTRLIEAEWQQPDTK
                     EKEKYMAEIQVYANNRTGLLVDLSKIFTERKIDLRSINSRTSKQEKATISMSFEIGSKE
                     ELRSLIEKIRQVESVIDVERTTG"
     CDS             19008..19637
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     163.1; E-value: 9.6e-50)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_17"
                     /transl_table=11
                     /translation="MKNLELQKCILGPVYTNCYLLKNKETGELIIVDPADCPEKIEMKI
                     SRMNGKPVAILLTHGHFDHILAAQAVKEKYNIPIYACRQEEEMLREPSINMTVHYGQGC
                     SIVPDVFLEDLDVIRLAGFSVQMIHTPGHTKGSCCYYLKDEGVLFSGDTVFYGSVGRTD
                     FPGGSTAEIVRSLHKLVDSLPEETEVFPGHDASTTIGYEKRYNPFV"
     CDS             19630..21144
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_18"
                     /sec_met_domain="PF04055 (E-value: 2.3e-24, bitscore: 78.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCKIGILFENRDFEHDVYELIKAFYPEAEIHTLYENAEAEYDLRF
                     SVEWDNDSYIIKYERTENLSKQETEQKGVISADILSKENAGCGIQDAHALRKENKDTIK
                     YALYQLLVKLTGRTLPWGNLTGIRPAKLAMGMIESGMKNTEAAREMRERYLVSPQKTAL
                     AITIANREREILKDIDYENGYSLYIGIPFCPSICLYCSFSSYPLKVWEKRTDEYVEALC
                     REVRETALMMKGRKLDTIYIGGGTPTTLLPHQIRKLLDTVGEAFGYEGLAEFTVEAGRP
                     DSITREKLMAIREYPVTRISVNPQTMNQETLDIIGRRHTVEQTKEAFHLARELGYDNIN
                     MDLIVGLPGEDIHMVERTLEQVRELAPDSITVHSLAVKRAARLNIFKEKYQEMSFENNQ
                     EIMDLTMKTAYEMGMGPYYLYRQKNMKGNFENVGYAKVDKAGIYNILIMEEKQPIIALG
                     AGGSSKLVFDHGQRIERVENVKDVSNYISRIDEMIERKRTAIATWL"
ORIGIN
        1 gccgctcacc aatggcagaa ttcattttta aagacatggt ttctaaacaa ggtctttcag
       61 accggtttta tatcgcatct gctgcaacca gcactgagga gatatggaat ggaatcggga
      121 atccggtata tcctccggcg cgagaggagc ttgctaagca tgggattgat tgtaagggta
      181 agcgcgcagt tcaactaacg aaggcagatt atgataaata tgattatatt ctcggtatgg
      241 accactggaa tctgaagaat atgttaagaa tattgaaatc agatccagag gacaaggtta
      301 aacttcttct ggattacagt gatgatccga gggatatcgc agatccgtgg tatacaggtg
      361 gatttgatgt cacatattcg gatgtggtgg agggctgtga ggcttttctg gaatatctga
      421 aagataaaaa gaaactgtaa taaatattgt cgatgaaatt tactttacaa atagctgtgg
      481 ctattttata ctatgtctac agcgactctt aagggggctt tcgctccctt attttctttt
      541 ttccgaaaac ggaaagtcaa cattcaaatc agggcatcct gcccgtatta ttttcaaagc
      601 aagaaaggaa ctgaatatgc agaaagacta tgaaacattc gtagagaaac tggagattgg
      661 tatttacgag gctacaggga ttccgaggga aaatatttct tttgagaaag aaggcgggag
      721 gtttgcacct gtaggagaca gactgctggt gaagtttgca gagcatgatg atgcctggga
      781 ggtctgtgga ctttatacac aggaactttt taaatcttat cagaatggca gtccgtttga
      841 ggaaattata aaagaaatca cagatgatct caatcggata aaaaaggcgg atatttatga
      901 gaaaacaaga gtgatcaggg attatgagaa gacaaaaccc cgcctgttta taagattgct
      961 gaatgcagat aaatattccg cggatcttca ggatgcggtg tataaaactc ttggtgatat
     1021 tgcacttgtg ctttatatga aagttacgga atatgaagga tgtgcgacaa gtacaaaaat
     1081 ccggcaggga atgctggagc agtggggaaa agaatgtgat gaggtgtttc aggaggcgat
     1141 tctcaatacg tattttatga gtccacccag aatttacaga tgggaacaga tgatttttaa
     1201 tccggaatat gaaggtgaaa gttttatgaa tctgggtgat aagtgtgaat tgaagaaaga
     1261 tgcaatggga aattgtctca gtacaacgaa gaaaacaaat ggtgcagttg cagtgttcct
     1321 gccgggagtg gcagaacaat tggcatatat gctggattcc gatttctata tggtgtttac
     1381 cagtgtacat gaggtaatga tccataatga taaatttgta gaacctgaag atttgcagtg
     1441 tgttttgcgg gatacgatca gggaggctac accgaaagag gactatctga cgtcgagaat
     1501 ctaccagtac aatagggaaa cacataaatt tatctgtgta actccgctgg aaaaagatga
     1561 gaaataaaaa tatgagagta ctccataaaa aagtactctc atataaagga tatttagaaa
     1621 cgttatgagt aatttatacg gttatccgag cagtgcagag tcattactga actcttctcc
     1681 gcttgctttt tcaaactgat ccagaaggtt tttaactgtc agttttttct tttcttctcc
     1741 ctggatatcc agaatgattt ttccttccat catcatgatc agacgattgc catgtgcaat
     1801 agcgtccttc atgttgtggg tgatcatcaa tgtcgtaagg tgatcgcggt ttacgatcat
     1861 atctgtaatt tccagaactt tggcagctgt tttcggatca agagctgcgg tatgttcatc
     1921 cagaagcaga agctttggtt tctgaagcgt tgccatcaga agagtaagag cctgtctctg
     1981 accacccgag agaagtccta ctttagaagt cagtctgtct tccagaccaa gaccaagaat
     2041 tttcaggagc tctttgtatt cttcgcgctc agctttagtg attccggagc ggagaagacg
     2101 ggattttccg cggcgttttg caagtgcaag gttttcctcg atacccattg ttgcagcggt
     2161 tcctgtcatt ggatcctgaa acacacgtcc aaggtatgta gcacgtttat gttcagaaag
     2221 ttttgtaaca tcaatattgt cgataaggat ctgtccttca tcaaccggcc aggttcctgc
     2281 aacagcattt agcatagtag atttgccggc gccgtttcct ccgataacag ttacaaaatc
     2341 gccttcgttc agcttcaggt tcagaccatt taatgcacgt ttctcattaa tggttccggg
     2401 attaaaggtt ttatagatat ttttaagttc aagcattttt atttacctcc ccttttggct
     2461 ggtttattaa agtatttgcc tttccagtat gggaatgcaa ggaagagagc aactacgatt
     2521 gcggacagca tcttcagcag gtcagtgtcg atacccatcc agataacaat ctgaagtacc
     2581 agataataca gaatggaacc gaagataact gctaacaggc gaagggcaaa gttgcggaaa
     2641 atacgtccaa agattgcctc gccaataata actgctgcca gaccgataac gatggaacca
     2701 cgtcccatgt tgacatctgc aaatccctga tactgtgcaa ggagtgcact ggaaagtcct
     2761 accagaccgt tggaaatcat aagtccgaga actttattcc tgtttgtgtt gataccctgg
     2821 gcgcgtgaca tatttgggtt acatccggtt gcgcgaaggg aacagccaag ctctgttcca
     2881 aaaaaccagt agagaatggc aatcaggaga atacacataa ctgctacaat aaaaattgtg
     2941 tttttggaaa gagatgcatt ttttatatgt cgcagggaaa ccagaagatt atatttatca
     3001 acgttgattg cctgatttgc ttttcccatg attttcaggt ttacggaata cagagataac
     3061 tgtgtcagga ttccggcaag gattgcggga attcccataa aggtgtgaaa aattccggtc
     3121 gcaaggcctg ccagcattcc ggcgagagta gcggccaaca tagaaatcca gacattatga
     3181 ccggaaagca tcatcataat acacactgca ccaccggtgc acatagtgcc atcaactgta
     3241 aggtctgcaa tatcaagaat acggaaagtg atataaacac cgattgccat aattccccag
     3301 atcagaccct gggctactgc acccggaagt gcagtgatta atgttataat ttgcatttgt
     3361 aatttcctcc tgttgagatg cgaaaagcga gagaggcgtc aaacctttcc cgctgatcgc
     3421 atataaattg aattttttat aactgtttga taggctgtta tttaaaatcc tgttggtgtg
     3481 agtatttttc aactgtctga ccggatttat ttggcagttt cttcagcagc ctcgccgatt
     3541 gcaacataat cgtccggaac ttcgatgccc agctcttcgc agatatcttt gttatattct
     3601 tttgtgaagt ttggtgcata ttcgatcggc attgtggaaa tatcttcacc gtcctttaaa
     3661 atcttaacag ccatcttacc ggttgtaaca ccaaggtcat aatagctgat ggaaagtgtc
     3721 gcaacaccgc atccgctgca gataccttct tcgcctgtga ttaccggaac ttttgccgga
     3781 aggcagatgt tgttgatgat ctctgtgttg gaagcaactg tattatctgt cggtacataa
     3841 attacatcac ttgcgtcagt tgctgttgta gcaacagaag agagatcatt agagtcagag
     3901 aatgcataat attcacatgt atatccgagt ttttcaagtt cagcttttac tgtatctacc
     3961 tgatactgag agtttgcttc ggcagaacag tagagaagac ctacattttt tgcatctggg
     4021 aaaagttcat tgagcattgc tgcctgctga tcaaggggag caaggtctgc agttccggaa
     4081 atatttccgc ccacagtccc gtcgaaatca tccagtccaa gtgcaacacc gtattcagta
     4141 acagaagtac caagaatcgg aatatcgctt gtccctgctg cagctgcctg aagagcagga
     4201 gttgcatttg caagaatcag atcaacatta ttggaaacga agctgttaat gattgtagaa
     4261 caggtgttgg aatctccctg tgcgttctgc tcgtcaaagg taactgcgtc ttctcccagt
     4321 tctttggtga cttcatcctt gaatccctgt gtcgcagcgt cgagagcttc gtgctgtaca
     4381 agctgacaga taccgattgt atatttgtct ccgtcagcag cacttgccgt tactgcgcag
     4441 gttcccatag ccatggctgc tgcaagagtg attgctaatg cttttctttt cataatgata
     4501 tatcctccta atataatgtt taaattaagt caggtaagaa ttgcgtttat tatttgataa
     4561 tataaaactt acctgaatcc gaaagatttt ctgcagggaa agcagtactg gtaaatgatt
     4621 cggataatgt catcgggcta ttcgactatg acgttttaaa gtataacgct ttagtgtgaa
     4681 aaagtcaagc gacctgcaca attatatttt taattcatat agtataaaga gtatatgaag
     4741 aaagcagagt gtcgtcatgg catattcgat catgctggat gccggacatg gaggtcagga
     4801 tccgggagcc gtatataagg gaagacagga aaagaatgac aatcttaaac ttgctcttgc
     4861 ggtaggtgag attttaaaaa ataaagggat tgatatctct tatacccgta ccggtgatgt
     4921 ctatcagaca ccttttgaga aggcacagct tgcaaatcag gcaggagtag attactttat
     4981 ttcatttcat cgaaacagca gcccaaagga aaatcagtat aatggagcgg aagttttgat
     5041 ttatgataaa agcgggatta aatatcagat ggctgagaat attctgggag ctctgggaga
     5101 agtgggattc cgcgaaatcg gtgtaaaaga gcggccggga cttgtggtcc tcagacgaac
     5161 caggatgccg gctcttttaa tagaaaccgg atttatcaat tccgaagaag ataataaact
     5221 gtttgataac aagtttagcg atatagctca gggaattgca gatgcgattc ttggaagcct
     5281 ggatgaggaa acagtgcagg aaccgcttta ttacagagtg cagactggag cgttcagaaa
     5341 aaaagagaat gcggaccgta tgttatatca gttactggaa aaaggttatc cctcttttat
     5401 gttacatgaa aacggattgt ataaagttca gacaggtgcc tatcagcaga ttggtaatgc
     5461 agtaaatatg gagcagagac tgagggatga tggttacagt acggttattg tgacaaaata
     5521 gccttctgga aatattggaa gtctgtgcat cgcgaagcgt gttgctgtga acagagtgaa
     5581 cagtaacata agcagtgggg gacatagttt taagaattaa cttggttgta cgttaataga
     5641 aaaaatatgg tacactgtat ctatctatag aaatcttcgt aaataatgca tattgttccg
     5701 gttcatcaga gcgtgaattt ttgttggact gttacaaacg cattatttga gaggtgctgt
     5761 agaaaaaaca gataacgagg agttagtaat gatgaatgac gtatatgaaa aatttttaaa
     5821 aagttcagaa gagtttattt ttgcagaaaa caagccggaa aaatctgata ttatttttgt
     5881 ccctggaaat ggttatccgc agatggcgga aaaagcagca gaattgttta agaaagggat
     5941 ggcggactgg attctgccca gtggaaaata cagcgtagta aatggaaagt tttcaggcgt
     6001 tcttgaaaaa agcaatgtat atgataagga atatggaaca gaatgggaat ttctcaggga
     6061 tgttcttata aaaaacggag ttccggatca gaaaatcctg aaagaagatc aggcaacctt
     6121 tacttatgag aacgcaattt attccagaca ggtgacagat catgcagaac tggaaataga
     6181 aagagcgatt ttgtgctgca aatcttacca tgcaagaaga tgtctgatgt attatcagct
     6241 cttgtatccg aaaacagaat tttatgtggt gcctgtgaat gcagatggaa ttaccagaga
     6301 aaactggaga aagaacgaag aaggaattga tgcggttaca ggagaactct ccagaatcgt
     6361 gaaacaattt tcactgatgc tggagagatg acagttacgg ctgttcttct gtttcggttt
     6421 tcttctcggg aagccagatg tggacaagtt cgattctgtt tttgtccaga cggtcaacaa
     6481 ccaggcggat gccactttca agtgtgacag actgaccctc tttgggaagg cagtcaagct
     6541 gttcaataat atatccgcca atagaatcat aatcttcaga ttccagatta atatggaggg
     6601 cttcgttgat atcatccagt ttggcagaac cctgaacaac atattctctt tcaggctgga
     6661 tttctttaat atcttcgact tcatcctcat cgtattcgtc gcgaatctca cctacgatct
     6721 cttccaacag gtcttccaat gtgaccagac cggctgtggc accgtattcg tccagaacga
     6781 ttgccagatt gacggatgct ttacgcattt cgatcatcag gtctgctgta gctttgtatt
     6841 cataggtaaa ataaggctca cgcaggatgt tgcggattga aaaaggtttg tcctttggat
     6901 aaacaagaag atctttcata ttgataatac cgattacgtt atcagtgttg tcctcataaa
     6961 ccggaaaacg ggtatgcata tcttcactga agaccgccat aagttcatca taggaaaaat
     7021 tgatatctat aaaggtcatg tcgattctgg gaatcatgac atcttttgca gttgaatcgc
     7081 caaaatcaaa cacattgtag atcatctgtt tttcttcgtt ttcaatgacg ccgtcttttt
     7141 cacctacatt gacgagagta cgcagttcat gttcagtcat ggcatttgcc ttttcgtccg
     7201 ggttaacatg cagaatgacc agtacacctt ctgttatttt atttacaatg aaaacaacgg
     7261 gagtaaggag aatcataagt ccgtatatta ttcttgaata ggccagggac aatttttcag
     7321 catggattgt tgccaggttt ttgggggtta tctcaccgaa aatgagaatc agcagagtca
     7381 ggatgccggt tgtgattcct acatatgcgt ttcccagaat ctttatggtg agtgtagtca
     7441 tgagagaaga aacagacata tttacaatgt tgtttccgat taatacggta ctgagcatct
     7501 ttggggaatt ggaaattatt ttttccagaa taacagcacg tttgttgcct tgctcggcaa
     7561 gagactgtat ccgaatctta tttacggttg tcatagcggt ttccgcagaa gaaaaaaatg
     7621 aagaaagtgc gatcagtatc agaatcgcca ccgcctgaaa ggcaatactt gaatccaaga
     7681 tttattcact ccttttgatt atttttattg attgaatcat atcataaaac atttaagcaa
     7741 aatatacatg atttcatata aaaaatcaag aaaaagcttt tggttcaaag atagtataaa
     7801 aaaatttaaa agaggactgt cgaaaaagta agatttgtgt tataattcac tcgattaaaa
     7861 tgaaaaaaaa cattacagaa tatttacaaa atgataaaag tttgataata tacagatatg
     7921 taatattatt gtattacgta aaaagagaac tgatatttgg ctgaaagtaa aaaatgatta
     7981 tcaggaaaca taagaatcga atataaatat agaggtgcga tatgtccaat aatataagaa
     8041 taagaaaaaa gaaattaaaa ggaacgggta tttttgcggc agcggcttta acagcggctt
     8101 tgattgcagg aaataatata ccgggtgtaa caagacaggt cagtgcggct gagtcacagg
     8161 agaatactgt gtcttctctg attccggaca acatcacgct tgataagcca gtagaacttg
     8221 cggatgtaga acttccggca acggaatatg gaacttttga atgggcagat ggaagtttcg
     8281 ttcctgcaca gcgtgtacag agctgtgagg tacttcttat accggcagaa gggcaggatt
     8341 taagccatgt ggatggatgg gatccggaga gcggcgcggt tgtcggttac atcaatgtaa
     8401 tagtgaacag tattacggat ggtgataatg ttgataagac agaaggctca ggtaaaacag
     8461 atccaacaga aaatgcagat ccaacagaaa cgcctgaaac ttcgtcagaa aaacctgccg
     8521 cagatgaaaa cgctgataca gacaataaag aagataagga aagtaaatca gatcaggata
     8581 ataaaactga tacagacaat gaagagagta agattgaaga agataaaaca gataataaaa
     8641 acaacaaaga taataacagc aatgcagata agacggataa agatacagaa actaccggta
     8701 agctggaacc tgcagatgat atgacacagg ataaagaaga tacgaagaaa gatgatgaag
     8761 atggcgcaga tgataatatc tttgataatc ctgttctgcc ggacgataag gatgaccgtc
     8821 ctacagatgc agaggattct ctttctgatg aagaaaaaga agagagggcc gcacttaatc
     8881 atacctgcga cggtattaca gtaagcggag ttaatcttcc atggtatgta cagttcagag
     8941 tttcaagcgg tgacagctat cagtttacca atgaatcaga tgcaatgatt ttccagtctt
     9001 atgaatttga actctgggat cttaagaata atacagaata tgagatccct aatggagatt
     9061 atatcagtgt cactgtgccg gtaaaatccg gatatcagta tactatcgaa catctcctgg
     9121 acaacggggc aactgagacg attattccga gtgtagagaa tggtattatg gtattcagca
     9181 cacattcttt cagtccattt ggaattgcag gaagcagaca attagtagga cctgatgcgg
     9241 ggaatgatac ggacgacaca gatgcggtaa ctcctgcacc ggcttcctcc gacagtcaga
     9301 gctctgattc cggaaagaac aatacagtat ctatgaatga cagttctgac agcaataatg
     9361 gttcttcttc tgatcagaat gataattcaa cggaaaataa agctgtgaaa aataacaata
     9421 cagtaaatac cggagataca acatcaatta tgccgtttgt gatactgttt gtggcagctg
     9481 cagtgatcgc cggtgtggtt gtatttataa aaaagagaaa gaaataaaag aataacactg
     9541 attcctcccc catatagttt aacaggaggg gaagcaatga aagtcagagc aattttgaaa
     9601 tcactattat ttgcatatgc attaacagga gtggcattac tgcttttggc cctggtactg
     9661 tttgcttttg atctgggaga aacagctgta gatgcgggta ttattataat ttatgtactt
     9721 gcatgtttca tgggaggctt tatggccggc aaaattgtgc gtaaagacaa atatctgtgg
     9781 ggtgttatca caggtctggc ttactatgta ttactgttga ctgtctctat tatggcaaaa
     9841 ggcggctggg atatgagtgc agcgcatgca gttacaacat tttttatgtg cacaggcggt
     9901 ggaacactgg gtggaatgct gtcgtaaaaa aaagctttta aaatgaaaag atatatgata
     9961 tactatgcca agaatataat tacataagga ggatagagtt atggaacata tcaaaaccct
    10021 gaatacaaag aatttacaga acactgtaaa aaaaggtgga tgtggcgagt gccagacttc
    10081 ctgccagtcc gcatgtaaaa cttcctgtac agtaggaaac cagagctgcg agcagaaata
    10141 agatcagcta tggagaaatg agataagcag cggaactttt attccgctgc ttatcttacg
    10201 cttagaaagg attttagtaa aatgagtctg attcaccgtt ataaaagcaa tggctttaat
    10261 attgtactgg atatcaacag tggatgcatc catctggtag atgaggttac atatgaggtt
    10321 cttccatatc tggaagaggg ccttggcaca gaagctattg cagagaaact ggaaaacaaa
    10381 tataacagag aagatattga gacatctgta agagaatgta ataagctgaa agaagatgga
    10441 atgcttttta caaaagatgt ttatgagaat gtaattgaag aattttcaaa taaccggcag
    10501 accgttgtaa aagcattgtg cctgcacatt gctcatgact gcaatctggc ctgccgttat
    10561 tgttttgccg aagaaggcga atatcatggc agaagagctc ttatgtccta tgaagtcggc
    10621 aaaaaagctc ttgatttcct gatcgcgaac tccggttcca gaaaaaacct ggaagtagat
    10681 ttctttggcg gcgagccgct gatgaactgg caggttgtaa aagatctggt aaaatatggc
    10741 agagagcagg aaaagcttca caataagaaa ttccgtttca ctttaacaac aaacggagtt
    10801 cttctgaatg atgaagtaat ggaattctgc aataaagaga tgggcaacgt tgtactcagt
    10861 gtggacggac gtaaggaagt acatgactac atgcgtccat tcagaaaagg tgcaggaagc
    10921 tatgacctga tcatgccgaa gttccagaag tttgcagaat ccagaaatca ggacaagtat
    10981 tatgtaagag gtacttttac tcaccataat cttgatttct ccaaggatgt gcttcatctg
    11041 gcagatcttg gattcaaaca gatttctgta gagcctgtag ttgcggctga tacggaggaa
    11101 tatgcgatcc gcgaggagga tatcccccag atcatggaag agtatgatac tcttgcaaaa
    11161 gaaatgatta aaagagagaa agagggaaaa ggatttaact tcttccattt tatgatcgac
    11221 cttacaggtg gcccttgcgt atacaagaga ctgtcaggct gcggttcagg aacagagtac
    11281 ctggctgtaa caccctgggg tgatttttac ccatgtcacc agtttgttgg tgaagaacag
    11341 tatctcatgg gaaatgtaga cgaaggcatc acaaagccgg aaatccagaa ggaattcggc
    11401 ggatgcaacg tttacacaaa gaaagactgc aaagactgct tcgcacgttt ctactgtagt
    11461 ggcggatgtg cggcaaatgc attccatttc cagggagata tcaaaggcaa ttatgaaatc
    11521 ggatgcgaac tccagagaaa acgtgtggag tgcgccatca tgataaaagc cgcactggca
    11581 tgtgattagt gggcagtaat ctgtctgact gataccgccg tcggctgtta tcataacaga
    11641 aaatggctgg caggcggatg aacatgaccg cggacaaaaa atcaagaagg gaaaagaact
    11701 atgaagaaaa gtaaaggaat cgtagtgctg cttttgacac tgatcctgac tgtgttcttt
    11761 tgctttactg cagccgtagg tatcggtcct accggaaccg gtgcagcaaa acatatcaac
    11821 acgggtcttg atcttgccgg tggtgtcagc attacctacc aggctaagga gagcaatccg
    11881 acaagcgaag agatgtcaga tacgatctac aagcttcaga agcgtgtaga gcagtacagt
    11941 actgaggctc aggtatacca ggaaggatca gaccgtatta cagttgaaat tcctggtgtt
    12001 acagatgcag atactatttt gaatgatctg ggtaaaccag gttccctgta tttcatcaca
    12061 aaagaagatg ctgacggaaa ccagaacttt actacaggac aggatggata tgttctctcc
    12121 agaactatgg atgagatcaa ggaatccgga agtgttgttc tggaaggttc tgatgtagca
    12181 gatgcccagg gtggtgcgat ccagaatcag aacacaagtg caaaggaata tgtggtaagt
    12241 cttactctta cttctgatgg agaaaacagt ggtaaaacaa aatttgcaga agctacaaag
    12301 aataatgtag gcaagcagat cgctatcgtc tatgacaata acattatcag tgctccgaat
    12361 gtaaatgaag agatttccgg cggaaaagca cagatcagcg gaatgtctga cctggaagaa
    12421 gcacagaacc ttgcttctta tatccgtatc ggttctctgg gactggaact ggaagaactt
    12481 cgttccagtg ttgtagctgc acagcttggt gaagaagcaa tctctacaag tgttcttgca
    12541 ggtgcgatcg gtctgatcat cgttattatc tttatgatca ttgcataccg cgtacctggt
    12601 gtagttgcag gtattgcact gattctttat acatcattaa tgctgatcac gctgaatgcc
    12661 tttgatatta ctcttactct tccgggtatt gcgggtatta tccttggtat cggtatggcg
    12721 gtggatgcca atgttattat ttatgcccga atcagagagg aaattggtgc aggagtttca
    12781 gtaaggaatt ctattaagtc cggtttcagc aaagctttct ctgcaatctt tgatggaaat
    12841 attacaacgc tgatcgcagc ctttgtgctg atgtggcttg gttcaggtac tgttaaggga
    12901 tttgcttata cacttgccct tggtatcgtg atctccatgt ttacagcact ggttgtatcc
    12961 agactgattg taaatgcact ttatgcagtt ggtgtacgtg atccgaaatt ctacggatct
    13021 gcaaaagaac gtaaggcagt tgatttcctt ggaaagaaga aagtattttt tgctatttcc
    13081 attatcctga tcctctgcgg tccggcagcg atgtttgcta attcgcatgc aggaaacaaa
    13141 gcgttaaatt acagccttga gttctcaggc ggtacttcta caactgttac atttaatgaa
    13201 gatatggata ttaagaccat tgattctgaa gtaactcctg ttgtagaaga ggtgacagga
    13261 gataaaaatg ttcagcctac aaaggtagtc ggaacaaatc aggttgtgat caagacacgt
    13321 tctctgaatc agagcgaacg tgaagctctg caaagtgcac tggttgagaa atttggtgta
    13381 gatgacagca cgatttccac agaaagtatt tcttctacag taagtagtga aatgcgtcgt
    13441 gatgcgatcg tagccgttat agtagctaca atctgtatgc ttctttatat ctggttcaga
    13501 tttaaagaca tccgttttgc aagcagtgcg gtattggcgc ttctgcatga tgttctggtt
    13561 gtacttgcat tctatgctat tgccagagta tctgtcggta atacatttat tgcctgcatg
    13621 cttacgatcg taggttattc tatcaatgct acaatcgtta tttttgaccg tatacgtgag
    13681 aaccttcaca gtggttccag agaaaaactg gcagaaattg taaacacaag tatcactcag
    13741 actcttacaa gaagtattta tacctctttt acaacttttg ttatggtagc tgttctttat
    13801 atcatgggtg tttcttctat ccgtgaattt gcagcacctc tgatggttgg tgttcttgtc
    13861 ggtgcatatt cttctgtatg tattacaggt gcgttgtggt atgtgatgaa aaagaaattt
    13921 gcaggaaaag gacagccggc aattgctgca gcctccgcat ctgcaaagtc ctcttcaaag
    13981 ccgaagaaag cacgtgatgt atcacagaaa gatccgactc agccaaagaa gaaaaacaga
    14041 aaaagagtag ctgaacgtct ggctgccgaa gaagcagcta aaaaacagca gaatgatgat
    14101 gctgaataaa acaataattg tctgaaaaac aggcagacag aaatatcccg gggtaaaact
    14161 ccgggatatt tttatgagga gagaaaatat atggagaaat gggtaatagc agcaaaaaga
    14221 gcagatttta accagatcgg tcaacagttt catattgatc cggtgattgc gagactgatc
    14281 aggaacagag atgtgatcgg agaagataag ataagagagt atctgtcagg aacagtacaa
    14341 gagcttcctt ctccctggct gatgaaggat atggaaaaag ctgtagatat cctggagaaa
    14401 aaaatatcgc agaaagcaaa agtccgtatt attggtgatt atgatattga tggtgtgacc
    14461 tctacataca ttttaatgaa aggtcttgcg aggatcggag cagatgtgga tacttatatt
    14521 ccggacagag ttgcagacgg atatgggatt catgcacatc ttatagaaag agcggaaacg
    14581 gaccggatcg atacgatcgt gacctgtgat aatggaattg ctgcggctgc tgaaatccag
    14641 atggcaaagg ataagggaat gacagtgatt attacagatc atcatgaggt tccttacagg
    14701 gaggaaaagg gagaacgcca gatggtgctt ccgccggcag atgcgatttt gaatccgaaa
    14761 caatatgatt gtccataccc gaataaaaac ctgtgtgggg cagtggtggc ctttaaatat
    14821 attgcagcac tttacgagag atttggtgtt ccggcagagg aactggaaga ttattatgaa
    14881 ctggcggcta ttgcaacagt aggagatgtt atggatcttc agggagagaa caggattctg
    14941 gtaaaagaag gactgtaccg tctgagaaat accaaaaatc aaggattgca ggaactgatc
    15001 cgagcaaatt ctctggaaga tgctaaaatc acagcttatc atatcggatt tgtgctggga
    15061 ccatgtatca atgccagtgg aagactggat acagctgccc gttctcttgc acttctcaat
    15121 gcaaaaacaa aggaagaagc agcaaggctt gccggagatc ttacagctct taatcagagc
    15181 cgaaaagctc tcactgagaa aggaaaagaa gaggcaatcc ggatcataga gactacagag
    15241 ctgaaaaatg acagagtact ggtagtttat cttccagatt gtcatgaaag tcttgccggt
    15301 attatagcag gcaggatcag ggaaaaatat cacaggcctg cctttgtatt gacgggcggt
    15361 gagacaagtg caaaaggaag tggaagatca atagaaagtt actctatgta tgaagaactg
    15421 gtaaaatgtg cagacctgat gatacagttt ggaggtcatc cgatggcagc aggtctttct
    15481 atagaagaaa aaaatataga agaattccgg agacgcctca atgtcaactg tacgttgacg
    15541 gacgaagaat tgcgtcctaa gatcgtgatt gatgtgccga tgcctgtgtc ttatattaca
    15601 aaagaactgg tagaacagat ttcgcttctg gaaccctttg gaaaagggaa tacaaaaccg
    15661 gtctttgcac agaaaaatct cagagtgctt gattacagta ttatcgggaa aaataaaaat
    15721 gtactaaaat taaaacttct cgatccgcag gggatttcag tggaaggcat ttatttcgga
    15781 gaagcagagg attttgtgaa cttcatcagg gaaaaagaca gtatttctgt tacttattat
    15841 ccggagatca acagattcag gggacgagag agtctccaga tcattattca gaattactgt
    15901 taatattacc gcctgttttg taaccgccgg taagcctgga aatacaaatg tcagggctta
    15961 acagtaactt gattctgaaa taaaaaggtg atatactata aaatatttat gagcgaacag
    16021 caatataaca cacactggag gagaaataaa atgaagaaaa ttgaagatta tgtattaagt
    16081 ataccggatt ttcctgaacc ggggattatt ttcagagata ttacaagtgt tctgcaggat
    16141 gcggatggcc tgcagctggc aatcgactcc atgcaggact gtcttaagga tatagatgtg
    16201 gacgtgattg caggaacaga gtccagaggc tttatctttg gtgtaccgat cgcatataat
    16261 cttcataaac catttgtacc gattcgtaaa aaaggcaaac ttccccgcga aacagtatct
    16321 gtaagctatg atctggaata tggcagtgca gagattgaaa tgcataaaga ttccataaaa
    16381 ccaggtcaga aagtggttat cgttgatgat ctgatcgcaa caggcggtac gatcgaagca
    16441 gcgatcaagc tggtggaaca gcttggcggt gaggttgtca aggttgtatt tctcatggaa
    16501 cttgcaggtt taaagggacg cgaaagactg aatgggtatg atgtagcgtc cgtaatttgt
    16561 tatgatggta aataagcaca gctgattgtg caggacaggc aggtgggagc atatgacaga
    16621 gataacaaaa agtacagaag caaaaaaaga tgaaatgcag gttgaaaaag agaagctgga
    16681 atctgtaaag agggcagatg cggcagtaaa gaccatgcat gattttacaa gtccggaggt
    16741 gctttataaa gaactgataa acagtgttct gaagtatcat ccatcaacag atatttccat
    16801 gatagagaag gcatataagg ttgcaagtga agctcatgaa ggacagaaga gaaagtctgg
    16861 agagccatat atcattcatc ctttgtgtgt tgccatcatt ctggcagatc tggaacttga
    16921 caaagaaacg atagttgcag gtcttcttca tgatgcagtt gaagatacct ggatgaccta
    16981 tgaggaagtg gagaaggaat ttggttcaga ggttgcactt cttgtggatg gtgttaccaa
    17041 gctgggacag ttatcttatt ctgcggataa agtagaagtt caggcagaga acctcagaaa
    17101 gatgtttctt gccatggcta aggatatcag agttattctg atcaagcttg cagaccgtct
    17161 tcataatatg cgtaccttac agtatatgcg tcctgaaaag cagcaggaaa aggccagaga
    17221 gaccatggat atttatgctc ctattgccat gcgtctgggt atttccaaga taaaggtaga
    17281 gctggatgac ctgtcgctga aataccttaa gccggatgta tattatgacc tggtgcataa
    17341 ggttgccctg cgtaaaagcg agagagaaca gtttgtaggt gcgattgtaa aagaagttaa
    17401 gaaacatatg gatgatgcca atattaaggc gcaggtggac ggacgtgtaa aacacttttt
    17461 cagcatctac aagaagatgg taaatcagga taagactatt gatcagattt atgatttatt
    17521 tgctgtccgt attcttgtag atacagtgaa ggattgttat gctgcccttg gtgtgatcca
    17581 tgagatgtat aagccaattc cgggacggtt taaagattat attgccatgc cgaaacccaa
    17641 tatgtatcag tcattgcata ccacattgat cggacccaac ggacagccct ttgaaatcca
    17701 gatccgtact tatgaaatgc atagaactgc agaatatggt atcgctgcac actggaaata
    17761 taaggagtcg tctgacggaa aggctcctgt aggtaagagt gaggaagaga aactgaactg
    17821 gctgcgtcag attctggaat ggcagagaga catgtctgat aacaaagaat tcatgagtct
    17881 tctgaagaat gacctggatc tttttgcgga cagtgtttac tgtttcactc cacagggaga
    17941 tgttaaaaca cttccaagcg gttctacacc ggtggatttt gcgtacagtg ttcacagtgc
    18001 agtcggaaat aagatggtag gtgccagagt taacggtaag ctggttccga ttgaatatga
    18061 gatcaaaaac ggtgaccgta ttgagatcat tacttcccag aactctcagg gaccaagccg
    18121 cgactggctg aaactggtta agagtacgca ggcaaagaac aagattaacc agtggttcaa
    18181 gaaggaatta aaagaagata atatccttaa gggcaaggag atgcttgcgc agtatgcgcg
    18241 tgcaaagggg tttaagatca caaattatac aaaaacccag tatctggagg ccgttttgcg
    18301 taaatatggt ttcagggact gggattcagt acttgctgca attggtcatg gcggattgaa
    18361 agaaggtcag gttttcaata agctggtaga ggcttatgat aaggaaaata agaagaatct
    18421 gacagatgag caggttcttg aggctgcttc tgagacacag gagaagcttc acattgccaa
    18481 gagcaagagc ggcattgtgg taaaaggaat ccatgatgtg gcagtccgtt tttccaagtg
    18541 ttgtaatcca atcccgggtg atgagattgt aggctttgtt acaagaggac gtggaatcac
    18601 aattcatcgt acagattgtg tcaatgtgct gaatatgtct gagacagaca ggacacgact
    18661 gattgaggca gagtggcagc agcctgatac caaggaaaaa gagaagtata tggctgagat
    18721 tcaggtttat gcaaataacc gtacagggct tcttgtggat ctttctaaaa tatttacaga
    18781 acgtaagatc gacctgcgaa gtattaacag ccgtacaagc aagcaggaga aggcaactat
    18841 ttccatgagt tttgagattg gaagcaaaga ggaactgcgt tccctgatcg agaagatccg
    18901 tcaggtagag agtgtcattg acgtagagag aactacaggc tgatcatgga aaaatctgct
    18961 ggaacattat tttatggaac tgctgcagat tgacagaaag gaataacatg aagaatttag
    19021 aattacagaa atgtatatta ggacctgtat atacaaattg ctatctcctt aagaataaag
    19081 aaaccggaga actgatcatt gttgatcccg cagattgtcc ggagaagatt gaaatgaaga
    19141 tttcccggat gaatggaaaa ccggtggcga ttcttcttac ccatggacat tttgaccaca
    19201 ttctggctgc acaggcagta aaggagaaat ataatattcc gatttatgcc tgtcgtcagg
    19261 aagaggagat gctccgcgaa ccttcgatca atatgactgt acattatgga cagggatgtt
    19321 ctattgtgcc ggatgtattt ctggaggatc tggatgttat cagactggcg ggattttccg
    19381 ttcagatgat ccatacaccg ggacatacca aaggaagctg ctgttattat ctgaaagatg
    19441 aaggtgtatt gttcagcggt gatacagtgt tctatggctc tgttggaaga acggattttc
    19501 cgggtggaag tacagcagaa atcgtgagaa gtctccataa actggtagat tcgcttcctg
    19561 aagagaccga ggttttcccc ggacatgatg catctaccac tattggttat gaaaagaggt
    19621 ataatccatt tgtgtaaaat aggcattctg tttgagaaca gagattttga acatgatgtt
    19681 tatgaactga tcaaagcgtt ttatcccgaa gcggagatac atactcttta tgaaaatgct
    19741 gaagcagagt atgacctccg cttcagtgtg gaatgggaca atgacagtta tatcataaaa
    19801 tacgaaagga cagagaatct gtcgaaacag gaaacagagc aaaaaggggt aatttccgca
    19861 gacatacttt ctaaagagaa tgcaggctgt ggaatacagg atgctcatgc tctgagaaaa
    19921 gagaataaag atactatcaa atatgctttg tatcagttgt tggtaaaact gacgggcaga
    19981 actcttccat ggggaaatct gacaggaata cgtcctgcca aactggcaat gggaatgatc
    20041 gaatccggaa tgaaaaatac ggaagcagcc cgggagatgc gtgagagata tctggtaagt
    20101 ccgcagaaaa cagcgcttgc catcactatt gcaaacaggg aaagagagat tctgaaggat
    20161 atcgactatg aaaatggata cagcctttat attggaatcc cgttttgccc aagtatctgt
    20221 ctgtattgtt ccttcagctc ctatccgctg aaagtgtggg agaagagaac agatgaatat
    20281 gtggaagctc tctgccggga ggtaagagag actgctctta tgatgaaggg aagaaaactg
    20341 gataccatct atattggcgg cggtaccccg actacactgc ttccacatca gatccgtaag
    20401 ctcctggata cagtgggaga agcttttggc tatgaaggac tggcagagtt tactgtggaa
    20461 gccggcagac cggacagtat tacacgtgaa aagctgatgg cgatcaggga gtatccggta
    20521 acaagaattt ccgtaaatcc acagactatg aatcaggaga ccctggatat tatcggccgc
    20581 agacatactg tggagcagac aaaagaagcg tttcatctgg cacgagagct gggatacgat
    20641 aacattaaca tggatctgat cgtaggtctt ccgggtgagg atattcacat ggtagagcgg
    20701 actcttgaac aggttcgtga actggcaccg gacagtatta ccgtacattc actggcagtg
    20761 aaacgtgcag caaggctgaa tatttttaaa gagaaatatc aggaaatgtc ttttgagaat
    20821 aatcaggaga ttatggatct gaccatgaaa actgcgtatg aaatgggaat gggtccttat
    20881 tatctgtaca gacagaagaa tatgaaggga aattttgaaa atgttggcta tgcaaaggtt
    20941 gacaaagcgg gaatttacaa tatactgatt atggaggaaa aacagcctat catcgcactg
    21001 ggggcaggcg gttcttccaa gctggtcttt gaccatggac agagaattga acgtgtggag
    21061 aatgtaaaag acgtttctaa ttatatttcc cgcattgatg agatgatcga gagaaaacgg
    21121 acagcaatag ctacctggct gtaggatgtg gaggtaacat tttggacaca gtacaaaaga
    21181 cagcagcagg ttcacagcag aggatcctgg aatttgacct tgcttctgaa ctgcatcatg
    21241 gaatgctggt aagtaatctg gcttatgcgg ttgcagagga gatgggactg ccgcatgaac
    21301 agtgttatga gcttgcaata gcaggaatgc tccatgatat aggaaagctg aagctgacaa
    21361 gttatattaa cggacaggag caggatcctc tggtgatcga ggaactgaag tatgtccgga
    21421 tgcattctgc attgggatat gaggaactta aagggcaggg atattcggat tttgtattgg
    21481 agagtatcct gtaccatcat gagaattatg atggtagtgg atatccgtcc aataaagcag
    21541 gtgatgatat acccataggt gcccggatac tcagagtctg cgatgtata
//
