LOCUS       gnlProkkaMLCGPKPE_9    15565 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MLCGPKPE_9.
ACCESSION   gnlProkkaMLCGPKPE_9
VERSION     gnlProkkaMLCGPKPE_9
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 22:40:36
            Original ID  :: gnl|Prokka|MLCGPKPE_9
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15565
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15565
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4200:5565]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4201..5565
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..15565
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15565
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             3..197
                     /locus_tag="ctg9_1"
                     /transl_table=11
                     /translation="MVETVKDKKSLGIYIGPEGGFPEEEVSFAMKAGAEPVTLGHRILR
                     TETAGMTLLSILMFMLEED"
     CDS             476..1393
                     /locus_tag="ctg9_2"
                     /transl_table=11
                     /translation="MEILSGVFEGKTTGTPISMAVFNKDQHSKDYSAIKDIYRPGHADY
                     TFDKKYGFRDYRGGGRSSGRETTARVAAGAVAAKVLKELGIEVFAYTKAIGPVQIDENR
                     FSKEERDKNALYMPDAQAAAQAEEYLQEKMKELDSCGGIVECVITGMPVGVGEPVFDKL
                     SANLGKAILSIGAVKGFEIGDGFAAAASAGSENNDDFYNDNGTVKKKTNHAGGVLGGMS
                     DGSVITFRAAFKPTPSIAQPQQTVNRDGKDTEIVIHGRHDPIIVPRAVVVVETMAAVTV
                     LDLLLQNMGSRLDSVKNFYENEKK"
     CDS             1462..2604
                     /locus_tag="ctg9_3"
                     /transl_table=11
                     /translation="MYKLLTKDGMAKRGEFETVHGTIQTPVFMNVGTVGAIKGAVSTDD
                     LRTIGTQVELSNTYHLHVRTGDKLIKQFGGLHKFMGWDKPILTDSGGFQVFSLSGLRKI
                     KEEGVYFQSHIDGHHIFMGPEESMQIQSNLGSTIAMAFDECPSSRADRTYIQNSVDRTT
                     RWLERCKKKMQELNSLPDTVNPHQMLFGINQGGVFADIRIEHAKRISELDLDGYAVGGL
                     AVGETHDEMYYILDEVVPYLPENKPTYLMGVGTPANIIEAVDRGIDFFDCVYPSRNGRH
                     GHVYTHHGKLNLFNKKFELDPRPIEEGCQCPSCRTYSRAYIRHLLKAKEMLGMRLCVLH
                     NLYFYNHLMEEIRGAIDEHRYKEFKKTTLEGFLTPEEEYR"
     CDS             2638..2958
                     /locus_tag="ctg9_4"
                     /transl_table=11
                     /translation="MLLAQSASASSSITMIIAYVILFGAIIYFMTIRPQKKQQKAADEM
                     HAGMQAGDSVLTTSGFYGVIIDIMDDTVIVEFGNNRNCRIPMQKDAIAAVEKPNLTKTE
                     EE"
     CDS             3314..3694
                     /locus_tag="ctg9_5"
                     /transl_table=11
                     /translation="MDGISYKKWMERAAGLFLSALIAVLLTMLFLAVFAFAMLKGNLSA
                     SVEKIGLIVMSVMACFVGGFLCGKKNMKKRYLWGLGVGVLYCLFFGVIRVGMGQAFVTD
                     TTAFFTMMLYCAAGGMLGGMLS"
     CDS             4201..5565
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_6"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3.3e-33,
                     bitscore: 104.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 7.5e-16, bitscore: 49.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 6.5e-14, bitscore: 43.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.4e-20, bitscore:
                     63.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYKNNGYNIVMDVCSGAIHVVDDVTYDVIALYEEKSLEEIEN
                     ELSYSKEDIEEAYKEVTSLKEEGLLFTEDIYEDYIKEVKSRKTVVKALCLHIAHDCNLA
                     CRYCFAEEGEYKGHRELMSAKVGKAALDFLVANSGNRHNLEVDFFGGEPTMNFGVVKEV
                     VEYGRSLEEKHNKHFRFTLTTNGVLLNDEIMEFANKEMDNVVLSVDGRKEIHDYMRPTR
                     NGKPSYDLIMPKFIRFAESRHQQKYYVRGTFTNRNLDFSKDVLHLADLGFEQISMEPVV
                     GQPEEPYAIQEKDLPQIFDEYDRLAKEMIKREKAGKGFNFFHFMIDLTGGPCVAKRLSG
                     CGSGTEYLAVTPWGDLYPCHQFVGEEKFLLGNVFDGIKRTDICDEFRSCNVYTKKKCKD
                     CFARFYCSGGCPANSYNFHGTIDDSYDLSCDMERKRVECAIMIKAALADTEGEEE"
     CDS             5566..6303
                     /locus_tag="ctg9_7"
                     /transl_table=11
                     /translation="MEKWFIASKRADFNKIGEIFHISPVTARLMRNRSLTTVREMQRYL
                     YGSLSDLYDSHLLKDADKGAEIIKEKIETGKKIRIISDYDVDGVSSNYILYQGLKRCGA
                     DVDYKIPDRVEDGYGINEHLIEKAAGDGIDTIITCDNGIAAAEQIAYGNSLGLTLIVTD
                     HHDIPFQRQEDGSISYNLPSAAAVINPKQKDCPYPFENICGAVVVYKFIQVLYDLFGID
                     RRESEAFLEIAAMATVCDXXXXM"
     CDS             6281..7360
                     /locus_tag="ctg9_8"
                     /transl_table=11
                     /translation="MTXXXVCDVMPLCDENRIIVKEGLQRIQHTNITGLQALIEANHLE
                     EKKISSYHFGFILGPCINASGRLTSAKDALELLLCEDKELCRQKAEALTQLNAERKEMT
                     ANGVKAAKEYLESTGHGNDKVLVVYLPNCHESIAGIIAGRMKEHYHKPVFVITRTKEGL
                     KGSGRSIEAYHMYKEMNKIKECFDKFGGHPMAAGFSMQEDRLEEFREKLNANATLTEDD
                     FAEKVHIDVALPISYLSESLINEFELLEPFGNENTKPLFAQKDLYIKGMRVLGTTGRCL
                     KLFLSDANGTSIDAMYFGESDGFLEELISFCGKEEAQRIQKGLSHHIWMDVTYYPQVNE
                     WRGQKNIQIVIQNYRFKNL"
     CDS             7530..7985
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179:hydrolase (Score: 82; E-value: 8.7e-25)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_9"
                     /transl_table=11
                     /translation="MEQEKKQPDVRLIGLDLDGTTLTSDKVLTPHTKEVLEKCLAEGIQ
                     VLPATGRVKSGIPEYLTQIEGMRYVILSNGASVLDLKEDKVLYQNCIPWERALELFDVL
                     ETYDTFYDIYALGAGWCEARFYDNVENYGIEKHIEXXXXGSYITQSY"
     CDS             7924..8382
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179:hydrolase (Score: 85.1; E-value: 9.4e-26)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_10"
                     /transl_table=11
                     /translation="MELRNISRXXXXVRTSRNRIDDLREWMKENKAPVEKINMFFAKEE
                     DRQRAFRELGKIEDLAVTCSLGNNLEINGATCNKGDAMLNLGKILDIPIESIMACGDGN
                     NDFEMVKMAGVGVAMKNGEESLKEVADFVTKTNDEEGVAYAIEHFCNV"
     CDS             8485..9042
                     /locus_tag="ctg9_11"
                     /transl_table=11
                     /translation="MPDLGAERVDKVKKLEDYVINIPDFPKPGIIFRDITSILRDPEGL
                     KLSVHELMHCLEGTEFDVVVGAESRGFLFGMPLAYNKSKGFVPVRKKGKLPRETVSKEY
                     ALEYGTAEIEIHKEDIRPGQRIVFVDDLLATGGTAKAAIDLIEELGGVVVKVLFVMELE
                     GLHGRDVLKGYDVESVITYPGK"
     CDS             9240..10109
                     /locus_tag="ctg9_12"
                     /transl_table=11
                     /translation="MEHLNLLQRIEKKSSEFSKGQRRLAQYITENYDIAAYLTASKLGK
                     EAGVSESTVVRFAYQLDYEGYPELQKAIQVIVKTNSNSIQRMSLSSKRYQEKGVLKSIL
                     YTDAERLRDTIQSGVDEEEFNRSVMLINDARRLYILGARSAAYLAGLMGYYFKMMFDNV
                     IIVDANSTSETLEQIYDISDKDVMMGITFPRYSKRTICALQYAKNHGAKTIALTDNMQS
                     PIVEYADCKLIAKSDVMTIVDSLVCPLSVVNAMVTAIALLRKDDVEKRLMALEELWNEY
                     DVYNRSLL"
     CDS             10109..11350
                     /locus_tag="ctg9_13"
                     /transl_table=11
                     /translation="MNKVIIVGGGAAGMMAAISASKEGKKVCILEKNEKLGKKLFITGK
                     GRCNITNACPADEFLTHVVTNPRFLYSTFSQFNNEDMMDYLEEIGLPIKTERGQRVFPQ
                     SDRSSDVIDALKKQCKKGGVQIYYHTEVKELLFDEEKENCVGVLLSDGKKMMGDSVILA
                     CGGFSYASTGSNGSGYTLAKQAGHKIKSIEPSLVPFEMKEMWCKDLMGLTLKNIGVRIK
                     AKKKTVYEGFGEFLFTHFGVSGPLVLTASTCLGKYQKELEAGELKLILDLKASLTPEQL
                     DKRFLREFDTYRNKNISNVMERLLPKKMIPVFLEEAQIPEDKKIRDISKKERRHMIELM
                     KNFEMHITGVRGFNEAIVTRGGVNVKEINPSTMESKKVKHLFFAGEMMDLDAVTGGYNL
                     QIAWTTGYVAGKNA"
     CDS             11486..12151
                     /locus_tag="ctg9_14"
                     /transl_table=11
                     /translation="MYSIAIDGPAGAGKSTIAKAIAEDIGFIYVDTGAMYRAIALYFLR
                     KGIDGHDRKLVAAECPNIHVTLEYDEEGKQQVILNGENVTGYIRKEEVGKMASVTSAVP
                     EVRAALLDLQRDMAKTSDILMDGRDIGTNVLPDASLKIYLTASADVRAKRRYDELKEKG
                     ADCDIEQIKTDIIARDKQDMEREIAPLCQAEDAILVDSSDMSIPQVIDTIISEFKKIK"
     CDS             12166..14052
                     /locus_tag="ctg9_15"
                     /transl_table=11
                     /translation="MMKINIAKSAGFCFGVKRAVDTVYKESSKKNVYTFGPIIHNDEVV
                     ADLERQGVHVINDSEDFKSLSEGTIIIRSHGVSKAIYDEILNAGLDLVDATCPFVRKIH
                     KIVERESGDGRVIIIIGNNHHPEVEGIMGWCHTHPIVIENREQAEGIELDADTKISIVS
                     QTTFNYNKFQELVEIISEKGYDINVFNTICNATEERQTEVRELAKKSDAMIVIGGRHSS
                     NTQKLFEISKKECSNTFYIQTKNDLNMEDFSNIGMLGITAGASTPNNIIKEVHESMAEM
                     SFDQMLEESFKTIRNGEVVQGTIIDVKEDEIILNIGYKADGIISRNEYSNDQNLDLTTV
                     AKVGDEMEAKVLKVNDGEGQVLLTYKRLKAEKGNKRLEEAFNNHEVLKAPVAKVLDGGL
                     SVVVEETRVFIPASLVSDTYEKNLKKYDGQEIEFVITEFNPRKRRIIGDRKQLLVAEKK
                     AKQEALFAKIEAGMTVEGTVKNVTDFGAFIDLGGADGLLHISEMSWGRVENPKKVFTVG
                     EKLNVLIKDIQGEKIALSLKFPETNPWLHADEKYAVGNEVTGKVARMTDFGAFVELEPG
                     VDALLHVSQIAKEHIEKPSDVLKVGQEVTAKVVDFKKDDRKISLSIKALDNE"
     CDS             complement(14588..15007)
                     /locus_tag="ctg9_16"
                     /transl_table=11
                     /translation="MTACGFLLYPLLLLCLLTKKNIAMLISFIAIPALCFLAVTIFRKV
                     VNKKRPYEKLPIQSLIKKDKKGQSFPSRHVFSIFLIATLWFCFWKPVGIFLFIAGVFLA
                     IVRVIGGVHFVTDVCAGALLGVLAGLISNYVFLIC"
     CDS             complement(15091..15240)
                     /locus_tag="ctg9_17"
                     /transl_table=11
                     /translation="MIPSFFDFVNKKFNVLKRFSFKQQKHYNNSLDSLFMLYLIYLFDN
                     EVYL"
ORIGIN
        1 aagtggtaga aacagtaaag gataaaaaga gtctgggaat ttatatcgga ccggaaggtg
       61 gttttccgga agaagaggtt tcttttgcga tgaaagcagg agcagaaccg gttacacttg
      121 ggcaccgcat tttgcggacg gaaacggcgg gaatgacatt actttctata ttaatgttta
      181 tgttagaaga agattgattt ggtgtagata gtagaaattt aattgataaa aagtcaaaca
      241 gaggatactc tgtttgacga tagaatttta acaggaggac aaaatggcag gttcatcatt
      301 tgggacattg ttttgtatga caacatgggg agaaacacac ggaaaaggtg tgggtgttgt
      361 agtggacggt tgtccggcag gcctttctct ttgtgaggag gatatacaga agtatttgaa
      421 tagaagaaag ccgggacagt caaagtacac aacaaagcga aaagaagatg ataaggtgga
      481 gattttatcg ggagtttttg agggaaagac aacaggaact ccaatttcta tggcggtatt
      541 taataaagac cagcattcaa aagattactc tgcaatcaag gatatttacc gtccgggcca
      601 tgcagattat acatttgata agaagtatgg tttccgtgat tatcgcggtg gcggccgttc
      661 ttcaggaaga gagacaacag caagagtagc agcaggtgca gtagcagcaa aagtattaaa
      721 agaacttggc attgaagtat ttgcttatac aaaagcaatt gggccagttc aaattgatga
      781 aaatagattt tcaaaagaag aacgagataa gaacgcatta tatatgccgg atgcacaggc
      841 agcagcacag gcggaagagt atcttcagga gaaaatgaaa gagttagatt cctgtggtgg
      901 cattgtggaa tgtgtaatta caggaatgcc cgtcggtgtt ggtgagccgg tatttgataa
      961 attaagtgcg aatcttggaa aagcaatttt atctatcgga gcagtaaaag gcttcgaaat
     1021 cggagatgga tttgcggcgg cagcaagtgc tggttctgag aataatgatg atttttataa
     1081 tgataatggt acggtgaaaa agaaaacgaa tcatgcaggt ggtgtgcttg gtggaatgag
     1141 cgatggttca gtaattacat ttcgtgcagc atttaagcca actccatcga ttgcacagcc
     1201 acagcagaca gtaaatagag atggcaaaga tacagaaatt gtaattcacg gaagacatga
     1261 cccgattatt gtgccaagag cagtcgttgt tgtagagaca atggcagcgg taactgttct
     1321 tgatctgctg cttcagaata tggggagccg cttagatagc gtaaaaaact tctacgaaaa
     1381 tgagaaaaaa taaggataga ggttgtacat ttgctttgtt tatgataaaa tcaaatttat
     1441 gtgtaaagtt aaggagagta tatgtataag ttattaacga aagatggcat ggccaaacga
     1501 ggagagtttg agacagtcca tggtacgata cagactcctg tttttatgaa tgtaggaaca
     1561 gtaggagcaa tcaaaggtgc tgtaagcacg gatgaccttc gtacaatcgg aacgcaggtg
     1621 gagctgtcta atacctatca tcttcatgta agaacaggtg ataaactaat caaacagttt
     1681 ggcgggcttc ataaatttat gggatgggat aaaccaatcc ttaccgattc tggcggattt
     1741 caggtgtttt ctctgtcagg tcttcgaaag ataaaggaag aaggcgtata tttccagtca
     1801 catattgatg gacatcatat ttttatggga ccggaagaaa gtatgcagat tcagtctaat
     1861 cttggttcta cgattgcgat ggcatttgat gaatgtcctt caagtcgggc agacagaacc
     1921 tacattcaga attctgttga cagaacaaca agatggttag aacgctgtaa aaaaaagatg
     1981 caggaattaa acagcctgcc agataccgta aatccacacc agatgttatt tggtattaat
     2041 cagggtggtg tttttgcgga tatccgtatc gagcacgcta aaagaatcag tgagcttgat
     2101 ttagatggtt atgcagttgg cggacttgca gtaggagaga cacatgatga gatgtactat
     2161 atccttgatg aagttgttcc gtatctgccg gaaaataaac caacttacct tatgggtgta
     2221 ggaaccccag caaatattat tgaggcagtt gacagaggaa tcgacttctt tgactgtgta
     2281 tatccttcca gaaatggaag acacggacat gtgtatacgc atcatggaaa gttaaatctt
     2341 tttaataaga agtttgaatt agacccccgc ccaatcgagg aaggatgcca gtgtccgtca
     2401 tgtcggacat acagcagagc ctatatcaga cacctgctca aggcaaaaga gatgcttgga
     2461 atgcgtcttt gtgttcttca taacctgtat ttctataatc atttaatgga agaaatacgt
     2521 ggagcaattg atgaacaccg ctacaaagag ttcaaaaaaa ccacattaga aggttttttg
     2581 acaccggaag aagaataccg gtaatatatt atatagaaga ataacggagg taaggacatg
     2641 ttattagcac agagtgcgag cgcaagctca tctattacaa tgatcattgc atatgtcatt
     2701 ctttttggag cgattatcta ctttatgaca atccgtccac agaagaagca gcagaaagca
     2761 gcagacgaga tgcatgcagg aatgcaggct ggagacagcg tattgactac aagcggattc
     2821 tatggcgtaa tcatcgacat catggatgac actgtaatcg tagaatttgg taacaaccgt
     2881 aactgcagaa tcccaatgca gaaagatgct attgcagcag tggagaagcc aaatcttaca
     2941 aagacagaag aagagtagtt tcggttagcg ggacagacga aaaatgaaaa agcagatatc
     3001 ctatatttgt gactctatca ctgcgggttg aatgttcgcc tccgggttca cattcaatcc
     3061 tcgctaaggc cacaaatata ggatatctgt tttttgctaa attgaaagta ctctccagtt
     3121 taacaaagac agaaattaag agaccgccaa tatataaaaa atgcgcctta gagcaagctc
     3181 ttaatgcgga cgagcattaa gagcgcagtg atacgaagca ttttttatat attggcggtc
     3241 tcttaatttc gtctcgcttg ttctaaacag agaacccttt tcataggcta taaaaaagcc
     3301 tttggtgcag cctatggatg gaatttcgta taaaaaatgg atggagcgtg cagcaggcct
     3361 gtttctttct gcattaattg cagtattact cacaatgcta tttttagcag tgtttgcatt
     3421 tgccatgttg aaaggtaatc tttccgcttc cgtagaaaaa attggtttaa ttgttatgag
     3481 tgtgatggct tgttttgtcg ggggattttt gtgtgggaaa aagaatatga aaaaacggta
     3541 tttatggggg cttggcgtag gtgttttata ttgcttgttt tttggagtaa tacgcgtcgg
     3601 gatggggcag gcatttgtga cagatacgac agcatttttt acaatgatgc tttattgtgc
     3661 ggcaggagga atgcttggag gaatgttaag ctaaaaagtt cttttcttac gggagggttt
     3721 gtgttataat aacctacaaa gtgtcatctt agatgcttta catactagat catgaagtga
     3781 ggaggcgtta ttaatgaaac gtgtaaagac actgaccgga aacaaaactt acggtactac
     3841 aatgtgtaaa ggtggatgtg gcgagtgcca gacatcctgc cagtctgcct gcaagacatc
     3901 ttgtacagta ggtaaccaga cttgcgagag taataaataa ttagagagca caacaggaag
     3961 aatgcttcct gatatatgct tgaagtaggg tgaactgtct tttttgtcag ttcaccttat
     4021 ctcttgtatg gaaaagtatg tttgcagaga ttactttatt gtaagttgaa aatattgtat
     4081 acaggaatgt tctgtattat atatctattt taaagttagc aggacatatc ttcaaattaa
     4141 aaatatattt tagaaaatta agtataaaaa ctataaaaga aatagaaagg gatatttaac
     4201 gtgattcacc agtataaaaa taatggatat aatattgtca tggatgtgtg cagtggtgcc
     4261 attcatgttg ttgatgatgt gacttatgat gtcattgctt tatatgaaga aaaaagcttg
     4321 gaagaaatag aaaatgaact ttcttacagc aaggaagata ttgaggaagc atataaagag
     4381 gtaacttctt taaaagaaga gggactttta tttacagaag atatttacga agattatatt
     4441 aaagaggtaa agagcagaaa gacagtagta aaggcacttt gcctgcatat tgcacatgat
     4501 tgtaatcttg cctgccgcta ctgttttgca gaagaaggag agtataaagg acaccgtgaa
     4561 cttatgagtg caaaggttgg aaaggctgcc cttgatttcc ttgtagccaa ttctggaaac
     4621 cgtcataatc ttgaagttga cttctttggc ggtgagccaa caatgaactt cggtgttgta
     4681 aaggaagttg tagaatatgg acgttctctt gaagaaaaac ataacaaaca tttccgtttc
     4741 actttgacaa ccaatggtgt gctgttaaat gacgagatta tggaatttgc caataaagaa
     4801 atggacaacg ttgttttaag tgtcgatgga cgtaaagaaa tccatgatta catgcgtcct
     4861 acaagaaatg gtaagccaag ctatgacctt atcatgccga agtttattcg ttttgcagag
     4921 tccagacatc agcagaaata ctatgtaaga ggaacattta ccaatagaaa tcttgatttc
     4981 tccaaagatg ttcttcatct tgcagactta ggatttgaac agatttccat ggaaccagtt
     5041 gttggacagc cagaagagcc atacgcaatt caggaaaaag accttccaca gatttttgat
     5101 gagtatgaca gacttgcaaa agaaatgatt aagagagaaa aagcaggaaa aggctttaat
     5161 ttcttccact ttatgattga ccttacaggt ggtccatgtg tagcaaaaag actttccggc
     5221 tgtggaagcg gaacagagta tttagcagta acaccgtggg gagatttata tccttgccac
     5281 cagtttgtag gagaagagaa attccttctt ggtaacgttt ttgatggaat caagcgtacc
     5341 gatatttgtg acgaattccg ttcctgcaac gtatacacaa agaaaaaatg taaagactgt
     5401 tttgcgagat tctactgtag cggcggctgt cctgcaaact cttataattt ccatggaaca
     5461 attgatgatt cttatgattt aagttgcgat atggagcgta agagagtaga atgcgcaatt
     5521 atgattaagg ctgcattagc agatacagaa ggcgaagaag aatagatgga aaagtggttt
     5581 atcgcttcaa aaagagcaga ttttaataaa attggtgaga tatttcatat cagcccggta
     5641 acggcgcgtc tgatgagaaa taggagctta acaacagtta gggaaatgca gcgttatctt
     5701 tatggctctc tgtctgattt atatgattct catcttttga aagatgccga taagggagcg
     5761 gaaatcataa aagagaagat agaaacaggc aaaaagattc ggattatttc ggattatgat
     5821 gtagatggtg tttcatcaaa ctatatttta tatcagggat taaaacgctg tggtgcggat
     5881 gttgattata agattcctga ccgtgtggaa gacggttatg gaattaatga acatctgata
     5941 gaaaaggcag caggggacgg aattgatacg attatcacct gtgacaatgg aattgcggca
     6001 gcagaacaga ttgcttatgg aaattcttta ggactcaccc tgattgtgac agatcatcat
     6061 gatattccgt ttcaaaggca agaagatgga agcatttctt ataatttgcc gtcagccgct
     6121 gccgttatta atccgaagca aaaagattgt ccgtatccat ttgaaaatat atgcggagcg
     6181 gttgttgtct acaagtttat tcaggtgctt tacgatttgt ttggaattga ccgtagagaa
     6241 agtgaagcat ttcttgagat tgcggcgatg gcaacagtat gtgacnnnnn nnnnngtatg
     6301 tgacgttatg ccattgtgtg atgagaaccg tattatcgta aaggaaggcc tgcaacggat
     6361 acagcatacg aatattaccg ggctgcaagc tttaattgag gcaaatcatc ttgaagaaaa
     6421 aaagatatct tcttatcact ttggatttat tctcggtccg tgtattaatg cttccggtcg
     6481 tttgacctct gcaaaagatg cgttagaact tcttctatgc gaagataaag aactttgcag
     6541 gcagaaagca gaagcactca cacagctaaa tgcagagcga aaagaaatga cagctaacgg
     6601 ggtaaaagct gcaaaagaat atctcgaaag caccggacat ggaaacgata aggtacttgt
     6661 tgtatatctt ccaaactgtc acgaaagtat cgccggaatt attgccggaa gaatgaaaga
     6721 acattaccat aagccagtat ttgtcatcac aagaacaaaa gaaggattaa aaggctctgg
     6781 ccgttctatc gaagcctatc atatgtataa ggaaatgaac aaaatcaagg aatgtttcga
     6841 taaattcggt gggcacccga tggcagcagg attttctatg caggaagacc gcttagaaga
     6901 attccgggaa aaattaaatg ccaacgcaac ccttaccgag gatgatttcg cagaaaaagt
     6961 tcacattgat gtagccttgc cgatatctta tttatccgaa agtctcatca atgaatttga
     7021 attactagaa ccatttggaa atgaaaacac aaaaccgctc tttgcacaaa aagaccttta
     7081 cataaaagga atgcgggtac tcggaacaac aggcagatgt ttaaaactct tcctgtcgga
     7141 tgccaatgga acaagcatag atgccatgta ttttggagaa tccgatggat ttttagaaga
     7201 actcatctct ttttgtggaa aagaagaggc acagagaatt caaaaaggcc tgtcacatca
     7261 tatatggatg gatgtgactt attatccaca ggtaaatgaa tggcgagggc agaagaatat
     7321 ccaaatcgtc atccagaatt atcgttttaa aaatttatga gataaatttt ttagtgcttc
     7381 tttcgcatat tttttcgtct atttagattc ccaattaata aaaactatcc taatttgaca
     7441 aataaggcga gaatcaatag aataatatga ggatgaaaag agagatacat caaaatcgct
     7501 atgaattaag agatagataa ggagaaaata tggaacagga gaaaaaacag ccagatgtca
     7561 gattgatagg attagattta gatggaacaa cgctcacttc agataaggtg ttaactccac
     7621 atacaaagga agtacttgag aaatgtcttg cggaagggat tcaggtttta ccggcaacag
     7681 gaagagtaaa atcgggtatt ccagagtatt taacacagat tgaagggatg agatatgtta
     7741 ttttatccaa tggtgcaagt gtattagatt taaaagagga taaagttctt tatcagaatt
     7801 gtattccgtg ggagagagca ttggagttat tcgatgtgtt agaaacatat gatacatttt
     7861 atgatattta tgcattagga gctggctggt gtgaggctcg cttttatgat aatgtagaaa
     7921 actatggaat tgagaaacat atcgagaann nnnnnnnngg ttcgtacatc acgcaatcgt
     7981 attgatgatt taagagagtg gatgaaagaa aataaagctc cagtggagaa gataaatatg
     8041 ttctttgcaa aggaagaaga cagacagaga gctttccgtg aacttggaaa gatagaagat
     8101 ttggcggtta cctgttctct tggtaataat cttgagatta atggggcaac ttgtaataaa
     8161 ggagatgcga tgctcaatct tggaaaaatt cttgatattc cgatagaaag tattatggcg
     8221 tgcggcgatg gcaataacga ttttgagatg gttaagatgg ctggtgtcgg tgttgctatg
     8281 aaaaacggag aagagtcttt gaaagaggtt gcagattttg tgacaaagac aaatgatgag
     8341 gaaggcgtag catacgctat cgagcatttt tgtaatgtgt aagtagaaat aaacgttttt
     8401 ctgttgtttt ttacataaaa aatctgttat aattaatcat aagaagaaaa agcgcgaaga
     8461 taaaagtctg tgcttaatag ttttatgcct gatttggggg cagaaagggt ggacaaagtg
     8521 aaaaaacttg aagattatgt cattaatatt ccagatttcc caaagccggg aattattttc
     8581 agagatatta cctctatttt acgtgatccg gagggactga aacttagcgt acatgaattg
     8641 atgcattgct tagagggaac agagtttgac gtagttgttg gagcggaatc ccgtggattt
     8701 ttatttggta tgcctcttgc ttacaataaa agcaagggat ttgttcctgt ccgtaagaaa
     8761 ggaaagctgc caagagagac tgtaagcaaa gaatatgctt tagagtatgg aacagcagag
     8821 attgaaatcc ataaagagga cattcgtcca ggacaaagaa tcgtatttgt ggatgacctt
     8881 ttagcaactg gtggaacagc aaaggctgcg attgatctga tcgaagaact tggtggcgtt
     8941 gtcgtaaagg ttctgtttgt tatggaactt gagggattgc atggccgtga tgtattaaaa
     9001 ggctatgatg tagagtctgt tattacttat cctggaaagt aattttgaag gaaaagaaac
     9061 tgtgtggatg gaattttttg gaagcacagt ttctctttgt gtaaaaattg ttctgtagtt
     9121 ataaagttga atttctattt gcaatttctt cctttaaatc ctgcattttg ctttacaaaa
     9181 agaagaaaat ggagtattat gaaatatact taattttaca gaataggtgg aagaatagag
     9241 tggaacattt aaatttatta cagagaatag agaagaagtc ttccgagttc agtaaaggac
     9301 agagaagact ggctcagtat attacagaga actatgatat tgcggcatat cttaccgctt
     9361 caaagcttgg aaaggaagca ggagtcagtg agtctacagt ggttcgtttt gcttatcagc
     9421 ttgattacga gggatatcca gagctacaga aggcaattca ggttattgta aagacaaatt
     9481 caaactccat tcagagaatg tccctttcct caaaaagata tcaggaaaaa ggtgtattaa
     9541 agagtatttt gtatacagat gcagagcggc ttcgcgatac gattcagagc ggtgtagatg
     9601 aggaagaatt taacagatcc gttatgctta tcaatgatgc aagaagatta tatattttag
     9661 gtgcgagaag tgcagcttat cttgccggtc tgatgggata ttattttaag atgatgtttg
     9721 acaatgtaat tatcgtagat gccaacagca cgtccgagac attagagcag atttacgata
     9781 tcagtgataa ggatgttatg atgggaatta cttttccaag atattcaaag agaaccatct
     9841 gtgcgcttca gtatgcgaag aatcatggag cgaagacaat cgcacttacc gacaatatgc
     9901 agtctccaat tgtagagtat gcagattgta aattaattgc aaagagtgat gtaatgacaa
     9961 tcgtggattc tttagtatgt ccgttaagtg tggtgaatgc gatggttaca gcgattgcat
    10021 tacttcgtaa ggatgatgta gagaagcgtc ttatggcact tgaagaactc tggaacgagt
    10081 atgatgttta taacaggagt ttactataat gaacaaagta attattgtag gcggaggggc
    10141 agccggtatg atggctgcca tttctgcgtc taaagagggg aaaaaggtct gcattcttga
    10201 aaagaacgaa aaacttggca agaagctttt tattacgggg aaaggcagat gcaatattac
    10261 aaatgcctgc ccggcagacg aatttcttac ccatgtggta acaaatccaa gatttttata
    10321 cagtacattt tcgcagttta ataatgagga tatgatggac tatttagaag aaatcggtct
    10381 tccgataaag acagagagag gacagagagt atttccacag tccgaccggt cttcggatgt
    10441 aattgatgca ttaaagaaac agtgtaaaaa aggcggggta cagatttact atcacacaga
    10501 agtaaaagaa ctactttttg atgaagaaaa agaaaactgt gtcggtgtac ttttgtctga
    10561 cggaaagaaa atgatgggag attctgttat ccttgcctgc ggcggctttt cctacgcttc
    10621 taccggttcc aatggatcgg gatacacact tgcaaagcaa gcaggacata agattaagtc
    10681 tatagaacca tctttagttc catttgagat gaaagaaatg tggtgcaaag atttgatggg
    10741 acttacttta aagaatatag gggtgcgtat caaagcaaag aaaaagacag tttatgaagg
    10801 atttggagaa tttctcttta cgcattttgg agtgagtggt ccgcttgttc ttacggcaag
    10861 tacctgtctt ggcaaatatc agaaagagtt agaggcaggc gaattaaaac tgattcttga
    10921 tttaaaagcc tctcttaccc cggaacagtt agataaacgg tttttaagag aatttgacac
    10981 ttatcgtaat aaaaatattt ctaatgtgat ggaacgtctt cttccaaaga aaatgattcc
    11041 tgttttctta gaagaagcac aaattccgga agataaaaag ataagagaca tcagcaaaaa
    11101 agaaagaagg catatgattg agctgatgaa gaatttcgag atgcatatca caggagtccg
    11161 tggctttaat gaggcaatcg tcacgagagg cggagtaaat gtaaaagaaa ttaatccgtc
    11221 tacaatggag tctaaaaaag taaaacattt attttttgcc ggagaaatga tggatttaga
    11281 tgctgtcaca ggcggctata acctgcagat tgcatggaca acaggctacg tagcaggcaa
    11341 aaatgcgtaa agaaaacgta aaatttaaaa aattataaaa aaatagtttt ttttttcgga
    11401 aaaatatgtt acactaatca agtgtaggta aaagtgaaat cactgtatac gcagtcaggt
    11461 ttcaaaagaa tgggaggaaa tgtccatgta tagtatagca attgatgggc cagcaggagc
    11521 tggaaagagc acgattgcaa aggcaatcgc agaagatata ggttttatat atgtagatac
    11581 cggagcaatg taccgggcaa tcgctttata ttttttgcgt aaaggtattg atggacatga
    11641 caggaagctc gttgcggcag aatgtcctaa cattcatgta actttagaat atgacgagga
    11701 agggaaacag caggttatct taaatggtga gaatgttacc ggatatatcc gtaaggaaga
    11761 agtcggtaag atggcatcag tgacatccgc tgttccagaa gtaagagctg cactgcttga
    11821 tctgcagcgc gatatggcga agacttcgga tatcctcatg gatggaagag acattggaac
    11881 gaatgtcctg ccagatgcat ctcttaagat ttatctgacg gcctctgctg atgtaagagc
    11941 gaagagacgt tatgacgaat tgaaagagaa aggtgcagac tgtgatatcg agcagattaa
    12001 gaccgatatt atagcaagag ataagcagga tatggagaga gagatcgctc cattatgcca
    12061 ggcagaagat gccatactgg tagattcttc tgatatgtca attccgcagg tgattgatac
    12121 gattatctcc gaatttaaaa aaataaaata atattgccgg agtaaatgat gaaaattaac
    12181 atagcaaaat ctgctggctt ttgttttgga gtaaagagag ctgtagatac cgtgtataaa
    12241 gaatcttcga agaagaatgt ttatacattc gggccgatca ttcacaatga tgaagttgtc
    12301 gcagatctgg aaagacaagg ggttcatgtc atcaatgaca gtgaagattt caagtctctt
    12361 tcagagggaa cgattattat tcgttctcac ggcgtgtcaa aagcaattta tgatgagatc
    12421 cttaatgcgg gtcttgattt agtggatgcg acctgccctt ttgtgagaaa gattcataaa
    12481 atcgtcgagc gggagagtgg ggatggcaga gtaatcatta ttataggcaa taaccatcat
    12541 cctgaagtag aagggattat gggttggtgc catacgcatc cgattgtaat tgagaatcga
    12601 gagcaggcag aaggaattga gttagatgct gatacgaaga tatctatcgt gtcccagacg
    12661 acatttaact acaataaatt tcaagaatta gttgaaatta tctcagaaaa gggttatgat
    12721 ataaatgttt ttaacacgat ttgtaatgcg actgaggagc gtcagacgga agtcagggaa
    12781 ctggcgaaga agtccgatgc gatgatagta atcggtggca gacacagttc gaatactcaa
    12841 aagctttttg agataagtaa aaaagaatgt agtaatactt tttatataca aacaaaaaat
    12901 gatttgaata tggaggattt ttctaatatc gggatgctcg gtattactgc aggggcttca
    12961 accccaaata atattatcaa ggaggttcat gaaagcatgg cagaaatgag ttttgaccag
    13021 atgctggaag aaagttttaa gacaatcaga aatggagagg tagttcaggg tactattatc
    13081 gatgtaaaag aggatgaaat catcttaaat attggatata aagccgacgg tatcatttca
    13141 agaaacgaat attccaacga ccagaattta gacttaacaa cagttgctaa agttggtgac
    13201 gagatggaag ctaaagttct taaagtgaat gatggcgaag gacaggttct cttaacatat
    13261 aagagactta aagcagaaaa aggtaataag agattagagg aagcatttaa caaccacgaa
    13321 gtattaaaag ctcctgtagc taaagttctt gacggtggtt taagtgttgt agtggaagaa
    13381 acaagagtat tcatccctgc aagccttgta tccgatactt acgagaagaa cttaaagaaa
    13441 tatgacggac aggaaatcga gttcgttatc acagagttca accctcgcaa gagaagaatc
    13501 atcggtgacc gtaagcagct tttagtagca gagaagaaag caaaacagga agcactgttt
    13561 gcaaaaatcg aagctggtat gactgtagaa ggaactgtaa agaacgtaac agatttcggt
    13621 gcattcatcg atttaggtgg agcagacgga cttcttcaca tctccgaaat gagctgggga
    13681 cgtgttgaga atcctaagaa agttttcaca gtaggtgaaa aattaaacgt tcttatcaaa
    13741 gatatccagg gagaaaagat tgcattatcc ttaaaattcc ctgaaacaaa cccatggctt
    13801 cacgctgacg aaaaatacgc agtaggtaac gaagtaactg gtaaagttgc tcgtatgaca
    13861 gacttcggtg cattcgttga attagagcca ggcgtagatg cattacttca tgtttctcag
    13921 attgctaaag agcacatcga gaaaccatct gatgtattaa aagtaggtca ggaagttaca
    13981 gctaaagttg tagatttcaa gaaagatgat cgtaagatca gcttaagcat caaagcttta
    14041 gataacgaat aatatttagc ggaatttggc taggtagacg aaaataaaaa agacttataa
    14101 tagcacctgt gactttagtc gcggcatgtt gaatgttcgc ttaagggctc gcatccaaca
    14161 cttgctccga ggtcacatct gctattataa gtctttttca ttttctgact ttggcgcaaa
    14221 ttccgctgtg gaggatttga ggattctcca gaagaggatg ggagtgggtg gaaaattttc
    14281 ttcgttatag ttaatgtttc actggcattt tatataattt tgctataaat aaaacttctt
    14341 ataagtataa tatatattat gtgaaaattt atatagaaag catttttaag tccacattta
    14401 aaaaagcagg aattagattt ctgcaattct cactttaatt tatcaaaaaa cagaaaaaag
    14461 cccctattaa tcctcccaga tgtgacctcg gagcaagtgt tggatgcgag ccttttagcg
    14521 aacattcaac acgtagcgac taaagtcaca tctgggagga ttaatagggg cttttttcgt
    14581 ctgtttttta gcaaatcaaa aagacatagt tggaaatcaa tcctgccagc accccgagga
    14641 gtgccccggc gcatacatca gttacgaaat gtaccccgcc aattactctg acaatcgcaa
    14701 gaaagacacc agcaataaaa agaaagattc caacaggttt ccaaaagcaa aaccataatg
    14761 tagcgattaa aaagatagaa aacacatggc ggcttggaaa agactggcct tttttatctt
    14821 ttttaattag ggattgaatt ggaagttttt catatggacg ctttttattc actacttttc
    14881 taaaaatggt tactgccagg aaacagagtg ctgggatagc gataaaacta ataagcatag
    14941 caatgttctt ttttgttaaa agacatagta ataataatgg ataaaggaga aaaccacagg
    15001 cagtcaataa tcgatttgcc gtgagtaata atgaaaaagc agtggagtgt ctgatgaaaa
    15061 aattattgat ttttgtatac tgttctaaat tcataaataa acctcattat caaaaagata
    15121 gattaagtat agcataaaaa gcgagtcaag ggaattatta tagtgttttt gttgtttaaa
    15181 ggaaaatctc tttaacacat taaacttttt atttacgaaa tcaaaaaaag atggtatcat
    15241 aagattatat ttcgtaaagg aaggaacatc ttatgggaaa aaatattcca aaagaacgta
    15301 aagaaggcat gtataaggct attctggagt taaaaagttt agaagaatgt tttgattttt
    15361 ttgaagacat ttgtgcaatg actgaacttc ggtctatgga gcagcgcttt gaagttgcaa
    15421 gtatgttgaa gaaggaaaaa gtttatacgg agattatgag tgaaacaaac gcaagttctg
    15481 ctacaattag tcgtgtaaat cgtatgctta attatggaac aggctgtctt ggagaggtaa
    15541 ttgacagact gaaccaaaaa gaggg
//
