LOCUS       c00031_gnlPro..        15162 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MLCGPKPE_31.
ACCESSION   c00031_gnlPro..
VERSION     c00031_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:57:13
            Original ID  :: gnl|Prokka|MLCGPKPE_31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15162
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15162
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[412:12135]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      413..12135
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15162
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /kind="single"
                     /product="OD_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15162
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="OD_AA_metabolism"
                     /region_number="1"
                     /rules="(minimum(1, [PFOR_II, POR, POR_N]) and minimum(2,
                     [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG,
                     Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /tool="gutsmash"
     CDS             complement(2..400)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_20"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:Dihydroprymidine dehydrogenase domain II, 4Fe-4S
                     cluster (Score: 71.7; E-value: 1.3e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg31_1"
                     /sec_met_domain="Fer4_20 (E-value: 1.5e-23, bitscore: 71.7,
                     seeds: 204, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKPTGFLEYERKESVGEAPLKRIKHFNEFHTPLSKKEQERQGAR
                     CMNCGVPFCQSGILIKGMVTGCPLNNLIPEWNDATYTGNWDEAYNRLRKTNPFPEFTGR
                     VCPHPCEVGCTCNLGGDPVNIKEKELSII"
     CDS             complement(413..4948)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: Glu_synthase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: Glu_syn_central"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg31_2"
                     /sec_met_domain="GATase_2 (E-value: 5.9e-173, bitscore:
                     564.2, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Glu_syn_central (E-value: 1.4e-112,
                     bitscore: 364.6, seeds: 570, tool: rule-based-clusters)"
                     /sec_met_domain="Glu_synthase (E-value: 1e-153, bitscore:
                     500.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYQDNMRQGLYDPSLEHDNCGIGAVVNIKGLKSHETVSNALKIVE
                     NLEHRAGKDAEGKTGDGVGILVQISHKFFEKTCSTLGFSIGKERDYGIGMFFMPQDELQ
                     RNRAKKMFEIIVEKEGLNFLGWREVPVQPGILGKKAADCMPCIMQGFVKRPFDVPRGLD
                     FDRRLYIVRRVFEQSNDSAYVVSLSSRTIVYKGMFLVGQLRLFYNDLQDKDYESAIALV
                     HSRFSTNTVPSWEKAHPYRYIVHNGEINTIRGNADKMLAREENMESDYLKDEMIKLTPV
                     VDPNGSDSARLDNTLEFLLMSGMPLPLAMMITIPEPWENNEGMSREKRDFYQYYATMME
                     PWDGPASILFTDGDIMGAVLDRNGLRPSRYYITDDDQLILSSEVGVLDFDTTHIVKKER
                     LHPGKMLLVDTVKGELIDDEILKDSYVKNQPYGEWLSDNLVFLKDLKIPNVAVEEYSYE
                     ESNRLMKAFGYSYEEVKDSVLPMALNGSEAIGAMGVDTPLAVLSKRHHPLFDYFKQLFA
                     QVTNPPIDAIREEIVTSTSIYVGGEGNVLEEKAENCHVLKIHNPILTNTDLLKIRYAKV
                     KNINVKDVPITYYKGTPLDKAINHLYVAVDQAHKNGANVVILTDRGVDENHVAIPSLLA
                     VSAVHHHLIETKKSTSVSIILESGEPREVHHFATLLGYGACAINPYLAQFSIKKLIQDG
                     LLKKDYYAAVNDYNNAVLHGIVKIASKMGISTLQSYQGSQIFEAVGISKKVIDEYFTNT
                     VSRVEGITIEDIAEDVDYHHSKAFDMLGLKNDLSLDSEGDHKYRSGKEEHLYNPLTIHT
                     LQTAAWTNNYELFKQYTSMINKETSPVSLRGLMDFNYPSKGVPIEEVESVDSIVKRFKT
                     GAMSYGSISKEAHETLAIAMNMIHGKSNTGEGGEDLERLTVGPDGLNKCSAIKQVASGR
                     FGVTSRYLVSAQEIQIKMAQGAKPGEGGHLPAGKVYPWIAKTRHSTPGVGLISPPPHHD
                     IYSIEDLAQLIYDLKNANRDARISVKLVSEAGVGTVAAGVAKAGAQVILISGHDGGTGA
                     APRNSSIHNAGLPWELGLAETHQTLIKNDLRNKVIIETDGKLMSGRDVAMAAALGAEEF
                     GFATGPLITMGCVMMRVCNLDTCPVGIATQNPELRKRFKGKPEYVVNYMKFVAQEMREY
                     MAKLGVRTVDELVGRTDLLKELPEAKEYHLDLSAILNNPYVDKKHPICYNKKNEYNFEL
                     EKTLDEKVLLTKLKTALDKKQKRSISIDVGNTDRSFGTIFGSEITKKYYNTLEDDTFTV
                     QCTGAGGQSFGAFIPNGLTLELVGDSNDYFGKGLSGGKLIVYPPKGIRFKAEENIIVGN
                     VALYGATSGQAYINGVAGERFCVRNSGATAVVEGVGDHGCEYMTGGKVLIIGKTGKNFA
                     AGMSGGVAYVLDEDNDLYLSLNKEMVSSEPVVSKYDVMEIKDMITAHVAYTNSEKGKEI
                     LNDFSKYLPKFKKIIPHDYKKMLKKISEMEGKGLSAEQAQIEAFYEIKRG"
     CDS             5855..6457
                     /locus_tag="ctg31_3"
                     /transl_table=11
                     /translation="MIINKFYEKLYKELINKLESDYILIPNTPENRKAINTTLTTVPCT
                     VKSLEKDSKIFKALSNKKAKAKQLSIVPKISKTLSLIIIATLICMPFNTINTLPTPTYH
                     PTVQVSILDISDGSSHQKGKNKLSEIQEQYTNKNQEQRNPKNYKKKVATNTYNTYKKQN
                     KFHLTLSTKKQLNFYQLLKSFFLKQKIHTIIYLMLMM"
     CDS             complement(6626..8380)
                     /locus_tag="ctg31_4"
                     /transl_table=11
                     /translation="MLYKEDFGEGKNIEFKREIPKRHEKLLKDVIAFSNSTGGKIFIGI
                     EDKTNEVIGIGEKNPFRLADDISNMIFDSCTPIIDPEITIQTLEGRTVVVVEVFPGRMR
                     PYYLKSFGKEQGSYIRINGTSRPADDRKLKELELEGQKISYDTLPEIDMEYSEREAKIL
                     CNAMEKVAYDVQTTCVTRAIQETSLDPKQNTEKTEIINKMTIEKLEDLGLLCRIGKDLQ
                     PTHAFRLMTKNKIRYAKIQCALFKGTERDIFIDKREFDGPLYVQLENAYQFVLKHINLG
                     AKIEGLHRKEAYELPVRTIRELITNAVVHRSYLDESCIQVCVYDDRIEVTSPGMLYGGL
                     DIQSAKSGKSKCRNTAIAEAFRYMGLIEAWGTGIPRMIKECREYGLREPVFEELGDGIR
                     VTIFRENEELEMRKRAENIQNAENKYQYMNNINSENLASVVKEQTVEYREQNHCFNTEK
                     SLFNALDSQGNEKKYCLNDEKTLFETTSQDKTHCFETSVLTAENKYMLYKKLKELQVNK
                     SIGSVTALNIKEIIESFSGEEVFGRKEIKQKLGYKDSKAGFLIQTMREFELIKAVKGRG
                     KGKYCFDI"
     CDS             complement(8578..12135)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: POR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) EKR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg31_5"
                     /sec_met_domain="PFOR_II (E-value: 1.8e-17, bitscore: 52.6,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 8.7e-78, bitscore: 250.1,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 8.4e-36, bitscore: 112.6,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.1e-13, bitscore:
                     37.8, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_7 (E-value: 3e-11, bitscore: 32.8,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00014, bitscore: 11.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.5e-19, bitscore: 58.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRAKQSMDGNTAAAHVAYAYTDVAAIYPITPSSPMADSVDQWAA
                     AGQENIFGNQVVVSEMQSEAGAAGTVHGSLAAGAITTTFTASQGLLLMIPNMYKIAAEQ
                     LPCVFDVSARTVATQSLNIFGDHSDVYACRQTGFAMLAETNPQEVMDLSPVAHLAAIEG
                     KVPFINFFDGFRTSHEIQKIEKWDYADLKEMCNMDAVKAFREHALNPEHPAMRGSHENG
                     DVFFQHREACNSVYEALPAVVKKYMGKINEKLGTNYDLFNYYGAEDADRVIIAMGSICD
                     VAEEVIDYLTAKGEKVGLIKVRLYRPWVSSALLDVIPKTAKKIAVLDRTKEPGALGDPL
                     YLDVATTLREAGLNDIVLTAGRYGLGSKDTPPSSVFAIYKELEKDAPKSRFTIGIVDDV
                     TNLSLPEVKPAPITSAPGTVECKFWGLGGDGTVGANKNSTKIIGDHTDKYIQAYFQYDS
                     KKTGGITISHLRFGDNPIRSPYYINQADFVACHNPSYVVKGYKMVQDVKPGGIFMINCQ
                     WSDEELDHHMPAAAKKYIADNNIQLYTINAIDKAIEIGMGKRTNTILQSAFFKLANIMP
                     IDEAVEFMKAAAKKSYSKKGDAVVEMNYKAIDAGVDAVHKVEIPASWSNPAADAPAKEL
                     TGRPETVKMVKKMMEPIGIMDGDSLPVSTFVDNADGQFELGASAYEKRGTAVSVPEWNP
                     EACIQCNQCAFVCSHATIRPFLVSEDEIKAAPDNMKVADTKPKASEYKFTMSVSPLDCM
                     GCGECITVCPAAAKGALKMVPQESQAAEQPVFDYLVATVGRKPGAPADTTVKGSQFNQP
                     LLEFSGSCAGCAETSYARLITQLFGEHMYISNATGCSSIWGGPAATAPYTVNKDSKQGP
                     AWANSLFEDNAEHGFGMYLGQKTLRDQAIAKLEKMAASDKASDEFKAAFAKFMETKDNT
                     KENTPDAQALIAEVEKAAAAGCPDAAEVLEKKQYLAKKSVWIFGGDGWAYDIGFGGLDH
                     VLASGENVNVMVFDTEMYSNTGGQASKASNIGEVCQFAAAGKEISKKSLAEIAMSYGYV
                     YVAQIALGANPNQAVKCLAEAEAYNGPSLIIGYAPCELHGIAKGGMNHCQDEMKKAVKA
                     GYWNLFSFDPAKKAEGKNPFTLTSKEGDGSYQEFLNNESRYTRLIKPFPERAERLFNES
                     EKVAKARYEHLQRLVELYK"
     CDS             complement(12785..13213)
                     /locus_tag="ctg31_6"
                     /transl_table=11
                     /translation="MIVIVSILLVISIIDFKIKIIPNQLNVLLFISGIWSGFVFQEVTF
                     LSRFLGVFSVSIPMFILAILCSGGLGGGDVKLMAASGVLLGIKWNIFAACAGLLLGGLY
                     GFFLLITKRAKRKDCFALGPFLCIGIAVVFFRYIFMKV"
     CDS             13579..14964
                     /locus_tag="ctg31_7"
                     /transl_table=11
                     /translation="MVKLIETVYNFLWGDLLTAPLPGGGTLPLSLLVILLIPTGVYFTI
                     RTKFLPIRLFKDMVGALFEKKDEEQSALSVIQTLIVSTATRVGMGNLVGVVAAISAGGA
                     GAVFWMWVTALIGSSTAFIEATLSQIYKEKDPLYGGYRGGPAYYIHRYFEEKSGKKKRY
                     VLLSVLFAISGLICWCGISQVVSNSVASAFKNAFHIPPIYTTVILVILAAIIVLRKNAT
                     VKVLDIIVPIMAGFYLLITLFIIITNITQLPGVFERIFSEAFGFRQVAAGGFGAVLMNG
                     IKRGLFSNEAGSGSAPCAAAAAVADNPVKVGLTQALGVFIDTLMICSCTAMIMLLTPTK
                     LTEGLVGMDLLQKAMEYHLGSFGVIFIAITLWLFSFSTFIGILFYARSNVAYLFGDNWF
                     SQTAYKVLALAMLFVGGLAAYTIVWDLGDVGIGLMTIFNIIMLYPLSKKALNALKEYEK
                     KKF"
ORIGIN
        1 ctataatact taactctttt tctttgatgt taaccggatc cccgcctaag ttacaggtac
       61 atccgacttc acaaggatgt ggacatacac gacctgtaaa ttctggaaat ggatttgtct
      121 ttctaagacg gttataagct tcatcccagt tacctgtgta agttgcatca ttccattcag
      181 gaatcagatt attaagcggg catccggtaa ccattccttt aatcaaaata ccggactggc
      241 aaaatggaac tccacagttc atacatcttg ctccctgtct ctcctgttct tttttggaca
      301 ggggagtgtg aaattcgtta aaatgtttga ttctctttaa cggcgcttct cccacgcttt
      361 cttttcgttc atattctaaa aatccagttg gttttcccat agcgctctcc tcctatcctc
      421 ttttaatttc gtaaaatgct tcaatctgtg cctgctctgc gctaagacct tttccttcca
      481 tttcggaaat cttcttgagc attttcttgt aatcgtgtgg aatgattttc ttaaacttcg
      541 gtaaatattt gctaaaatca tttaaaattt ctttaccttt ttcagagttt gtatatgcca
      601 catgggcggt aatcatatcc ttaatttcca taacatcata tttagaaaca actggttcgg
      661 aagaaaccat ttccttgttg aggcttaagt ataagtcgtt atcctcatca agaacgtagg
      721 caacaccgcc gctcattccg gctgcgaagt tctttccagt cttaccgata attaagactt
      781 taccaccagt catgtactcg catccgtgat cgccgacacc ttctacaaca gctgttgcac
      841 cggagttacg aacacagaaa cgttcaccag ccacaccatt aatataagcc tgaccgcttg
      901 ttgcaccgta aagtgctacg ttaccaacga taatattttc ctcggctttg aagcggattc
      961 cttttggagg gtaaacgatt aatttaccac cggataatcc ttttccgaag tagtcattac
     1021 tgtcaccgac aagctctaat gtaagaccat ttggaataaa tgctccaaag ctctgtccgc
     1081 cggctcctgt acactgtaca gtaaatgtat catcttccag tgtgttgtaa tatttctttg
     1141 taatttcaga accaaagatt gtaccaaagg aacggtctgt atttccaaca tcgatagaaa
     1201 tgcttctctt ctgcttttta tcaagcgctg tcttcaactt agtaagaaga actttttcat
     1261 ctaatgtctt ttctaattca aagttgtatt cattcttctt gttgtagcag attggatgct
     1321 tcttatctac atatggatta tttaaaatag cagataaatc taagtggtac tcttttgctt
     1381 ctggaagttc tttcagaagg tctgtacgtc ctactagttc atctacagtg cggacaccaa
     1441 gttttgccat gtattcacgc atttcctgtg caacgaactt catgtagttt acaacgtatt
     1501 ccggtttacc tttaaaacgt tttctaagtt ccggattctg tgttgcgata cctactggac
     1561 aagtatctaa gttacaaact ctcatcataa cgcagcccat tgtaatcagc ggaccagtag
     1621 caaatccaaa ttcttctgct ccaagtgctg ctgccattgc tacgtcgcgg ccgctcataa
     1681 gcttaccgtc cgtctcgatg ataactttat tacgaaggtc atttttaatt aatgtctggt
     1741 gtgtctcagc aagtccaagc tcccacggaa gtccggcatt atggatagaa gaattacgag
     1801 gtgctgcacc tgtaccaccg tcatgtccgg aaataaggat tacttgtgcg ccagcttttg
     1861 ctacacctgc tgcgactgtt ccgacacctg cttcggatac cagttttaca gaaatacgag
     1921 catccctgtt cgcatttttc aagtcataaa ttaactgtgc taaatcttcg atactgtaaa
     1981 tatcgtgatg aggtggtggt gaaataagtc ctacaccagg tgttgaatgt cttgtctttg
     2041 caatccaagg atatactttt cctgctggta aatgtccacc ttcaccaggt tttgctccct
     2101 gtgccatctt aatctgaatt tcctgtgcac ttacaaggta acggcttgtt acaccgaaac
     2161 gaccggaagc tacctgcttg attgcagagc atttattcag tccatctgga ccaactgtca
     2221 gacgctctaa atcttctcca ccttcaccag tgtttgattt accgtgaatc atgttcatcg
     2281 cgattgccag agtctcatgt gcttccttgg aaatagaacc ataactcata gcacctgtct
     2341 taaatcgttt cacgatagaa tctacagatt caacttcctc gataggaact cctttggatg
     2401 gataattgaa atccattaat ccacgaagac ttactggaga agtttcttta ttaatcatgg
     2461 aagtatactg tttaaacagt tcataattat ttgtccatgc tgctgtctgt aatgtatgga
     2521 tggtcagtgg attgtaaaga tgttcttctt taccacttct atatttgtga tcaccttcac
     2581 tgtcaagact aagatcattt ttcagtccta acatatcaaa tgctttggag tgatggtaat
     2641 ctacatcttc tgcgatatct tcaattgtga taccttctac acggcttact gtgtttgtaa
     2701 agtactcatc aatgactttc ttgctgatac caactgcctc aaaaatctga gaaccctgat
     2761 aggactgcag tgtggaaata cccatcttag atgcgatctt tacgataccg tgaagtactg
     2821 cgttattgta atcatttact gctgcatagt aatctttctt taataaacca tcctgaatca
     2881 gcttcttaat actgaactgt gccagatatg ggttgatagc acatgcgccg taacctaaca
     2941 gtgtggcgaa atgatgtact tctcttggtt caccactctc taagataata cttacagaag
     3001 tactcttctt tgtctcaatg agatgatgat gtacagcaga tactgctaac agagatggaa
     3061 ttgccacatg gttctcatca acacctctat ctgtcaaaat aacaacattt gcaccatttt
     3121 tatgcgcctg gtcaacagca acatataaat gattgatagc cttatcaagc ggtgttcctt
     3181 tgtaataagt aatcggcaca tcttttacat tgatattctt tacctttgca taacgaatct
     3241 ttaataagtc tgtatttgtt aaaatagggt tgtgaatctt taatacatgg cagttttctg
     3301 ccttttcttc caacacattc ccctctccgc caacatagat ggaagtagat gtaacgattt
     3361 cctcacgaat cgcatcaata ggagggtttg ttacctgtgc aaaaagctgt ttaaagtaat
     3421 caaataatgg atgatgtctc ttagaaagta ctgctaatgg agtatcaacc cccatcgctc
     3481 cgattgcttc acttccgttt aatgccatcg gtaatacaga atctttcact tcttcataag
     3541 agtaaccaaa tgctttcatc aggcggttgc tctcttcata gctgtattct tctactgcaa
     3601 cattcggaat ctttaagtct tttaagaata caaggttatc ggataaccat tcaccgtaag
     3661 gctgattctt tacataagaa tcttttaaga tttcatcgtc aatcagctca ccttttacag
     3721 tatctacgag aagcatttta cctgggtgaa gtctctcttt ctttacgata tgtgttgtgt
     3781 caaagtctaa cacaccaacc tcagaagaaa gaattaactg gtcatcatct gtaatatagt
     3841 aacgggaagg tctaagacca ttacggtcaa gtacggctcc catgatatct ccatctgtaa
     3901 agaggataga tgcaggacca tcccaaggct ccatcattgt tgcgtagtac tgatagaagt
     3961 ctctcttctc tctgctcatg ccctcgttat tttcccaagg ttctggaatc gtgatcatca
     4021 ttgccagagg aagtggcatt ccactcatta agaggaattc taatgtatta tctaatcttg
     4081 cagagtcaga accgtttgga tctacaactg gtgtcagctt aatcatctca tccttcagat
     4141 aatcagattc catgttttcc tcacgggcta acatcttatc ggcattacca cgaatagtat
     4201 taatctcacc attatgaacg atgtaacgat aaggatgtgc tttctcccag cttggaactg
     4261 tgtttgtgga gaaacgggaa tgaactaatg cgattgcaga ttcataatcc ttatcctgaa
     4321 ggtcattata gaataatctt aactgtccaa ctaagaacat acctttatat acgattgttc
     4381 tgctgcttaa agaaacaaca taagcagaat cgttagactg ctcaaatact cgtcttacaa
     4441 tataaagtct tctatcgaag tcaagtcctc gtggaacatc aaacggtctc tttacaaatc
     4501 cctgcataat gcatggcata cagtccgctg ctttctttcc gaggatgccc ggctgaaccg
     4561 gaacctctct ccagcctaag aaatttaagc cttctttttc aacgataatc tcaaacatct
     4621 tcttagcacg gtttctctgt aactcatcct gtggcataaa gaacatacca ataccgtagt
     4681 cacgttcctt gccaatagaa aagccgagag tactacaggt tttttcgaag aacttatggg
     4741 atatctgcac taagatacct actccgtcac ccgttttacc ctcggcgtcc ttgccggctc
     4801 tatgttcaag attttcaaca attttcaagg cattcgatac tgtctcatgg ctcttaagac
     4861 ccttgatgtt tactacagca ccaataccac agttatcatg ctccagactt ggatcatata
     4921 gaccctgtcg catattgtcc tgatacatgg tctcaccctt tcttgcatca ctatgaaata
     4981 gtaaatattc atcagttgta aattatattt ttgtaattag taattatcag gaactcttaa
     5041 tcaaacctta tgattctcat gttctcatgc tcttgtaatc ttatgatttc ataatcctga
     5101 atgagtatct atagtctgaa taaaaatcta taaatctctg aataattaca tatttaaaaa
     5161 gtaacaaatt cattttcaga agtagttgta atgacttcct gcatttcttt ttgttgttat
     5221 catattacaa cattttaaat aggttgtaaa tataaacatt aaggtgagtt gtctaataat
     5281 ttgattattt attttttaat atattatttt ctgattatta ctcttgtttt aggggatatt
     5341 gtagttagtt tatttggttt ttatttcttt ttagattata ttgttcttat aaaagtacaa
     5401 ttttgtttgt gatttcacct ctttattcat cgttattttc agatttaaag acaattcata
     5461 caattataaa tgtaattttc aaatacaaat cctgcatttt attaacattg tatacaaaat
     5521 aacttaagaa aattaagtaa gtaattggtt gaattctaca attttattcc attgtctaaa
     5581 ctagcatact atttgtagtg aaaaagcaaa aaaagaatcg gattcttttt tcgtaaacta
     5641 tcttttcaaa aagaaaattt ccctaatctc tcatactaat gtaagaaagg agattttaat
     5701 tacacacatg gcaaatcaga gcaatacaaa aagaaaaaat tatacatatt aataataatc
     5761 aacaaaaaat gttgaaattc gatacagaaa ggagaggcca tttcgcaaaa aaatacgcat
     5821 ttattattat agaaaaaaga aagaagaaat cacaatgatt attaacaaat tttatgaaaa
     5881 actctacaag gaacttatca acaaactaga atctgattat attttaatcc ctaacacgcc
     5941 agaaaataga aaagcaatta atactactct cacgacagtc ccttgcactg taaaatcttt
     6001 agaaaaagat tcaaagattt ttaaagcttt atctaacaaa aaagctaaag ctaagcagct
     6061 ttcaattgta cccaaaattt ctaaaacttt atctcttatt ataatagcca ctttaatttg
     6121 tatgccattt aataccatta acactctccc aacgcctacc taccacccta ctgtacaagt
     6181 tagtatttta gatatttctg atggatcttc tcaccaaaaa gggaaaaata aattatccga
     6241 aatacaagaa caatacacaa acaaaaacca agagcaacgt aatcctaaaa actacaaaaa
     6301 gaaagttgct acaaatacat ataatacata taagaaacaa aataaattcc atttaacatt
     6361 atccacaaaa aagcaactca acttttatca acttttaaaa agttttttct taaaacaaaa
     6421 aatacatacg ataatttatc tgatgcttat gatgtaatta gtactttatt tgtattgatt
     6481 tccacagtaa aagaatctat acgctcaaaa aaattaaaat agtccttcta tataatttta
     6541 ttcaatacta ttttcaatta tacattaaag ccgttcttca cagaagtacg gctttaaatt
     6601 ttcttatgaa agccaagata gagttttaaa tatcaaaaca atactttccc ttgccccttc
     6661 ctttcacagc tttaatcaac tcaaattccc gcattgtttg aatcagaaat cccgccttac
     6721 tgtctttata tcccagtttt tgttttattt cttttcgccc aaagacttct tctcctgaaa
     6781 agctttcgat aatctccttt atatttaatg cagtgacgct acctatgctt ttattaactt
     6841 gtagttcttt cagcttttta tataacatat atttattctc tgcagtcaat acagacgttt
     6901 caaaacagtg ggttttatcc tgacttgttg tttcaaacag tgttttttca tcattcaaac
     6961 agtatttttt ttcatttcct tgtgaatcca gcgcattaaa cagtgatttt tctgtattga
     7021 aacagtgatt ttgctctcta tattccactg tttgttcttt tactacagat gctaagttct
     7081 cactatttat attattcata tactggtatt tattttcagc gttctgtata ttctccgccc
     7141 gttttcgcat ctccaattct tcattttccc ggaatatagt tactcgtata ccatctccca
     7201 gttcctcaaa cactggctct ctcaatccat attctctgca ttcttttatc attcttggga
     7261 ttcctgttcc ccacgcttct ataagtccca tataacgaaa tgcttcagca atcgctgtat
     7321 ttctgcactt tgatttacct gatttagctg actgtatatc cagtccccca taaagcattc
     7381 cgggagatgt tacttctatc ctgtcatcat agacacaaac ctgtatacaa gactcatcca
     7441 aataacttct atgaacaact gcattagtaa tcaattctct tattgttcga accgggagtt
     7501 catacgcttc ttttctatgt aacccttcta tctttgcacc aagattgata tgctttaata
     7561 caaattgata agcattttcc agctgtacat ataatggtcc atcaaattct cttttatcta
     7621 taaaaatatc tctttctgtt cctttaaata acgcacattg aattttggca taccgtattt
     7681 tattcttcgt cattagtcta aacgcatggg tgggttgaag gtcttttcct attcggcaca
     7741 ataaccctaa gtcttctagt ttctcgattg tcattttatt tataatttca gttttttctg
     7801 tattttgctt gggatctaat gacgtttcct gtattgctct tgttacacat gttgtctgca
     7861 catcatatgc cactttttcc attgcattac ataatatctt cgcctctcgt tccgagtact
     7921 ccatgtctat ttccggtaaa gtatcataag aaatcttttg accttctaat tctagttcct
     7981 ttaactttct atcatcagca ggacgacttg taccatttat tcttatataa gaaccttgtt
     8041 ccttcccaaa tgacttgaga taataaggac gcatacgtcc tggaaaaact tctacaacaa
     8101 caactgttct tccttctaat gtctgtattg taatttccgg atcaattatt ggagtgcagc
     8161 tgtcaaatat catatttgaa atatcatctg ctaatctaaa tggattcttc tctccaatcc
     8221 caataacttc attcgtctta tcctcaattc caataaaaat tttacccccc gtagaattgg
     8281 aaaaagcaat aacatctttt aataacttct catgtctttt cggtatctct cttttaaatt
     8341 ctatattttt tccttctcca aaatcttctt tatatagcat tcctgtccct cttcaaaacc
     8401 attgtcagta catctatcag tcattaattt gttatgattt attataatac aattcccttc
     8461 tttttttcaa cacacaagaa gaagccatgc accagcatag ctagcacacg gcttctcttt
     8521 tgtattttat aaagttttat cttttgtaac taatctgact gaccagttca ggctttatta
     8581 tttataaagc tcaacgagtc tctgcaggtg ctcgtaacga gccttagcaa ccttctcaga
     8641 ttcgttgaag agtctttcag ctctttctgg gaatggctta atcagacgag tgtaacggga
     8701 ttcgttattt aagaattcct gatatgatcc atcgccttct ttagatgtta atgtgaatgg
     8761 attctttcct tcagctttct tagctgggtc gaaggagaag aggttccagt aaccagcctt
     8821 aacggctttc ttcatctcat cctggcagtg gttcatacca cccttagcga taccgtgaag
     8881 ttcacatgga gcgtatccga tgatcaggga tggtccgttg taagcttctg cttctgcaag
     8941 acatttaact gcctggttag ggttagcacc aagagcaatc tgtgcaacgt atacgtatcc
     9001 gtagctcata gcgatctctg caaggctctt cttgctgatt tctttaccag ctgctgcgaa
     9061 ctgacaaacc tcaccgatgt tagaagcttt agaagcctgt ccacctgtgt tggagtacat
     9121 ctcagtatcg aataccatta cgtttacgtt ctcaccagaa gcaagtacat ggtctaatcc
     9181 accgaatccg atatcatatg cccatccgtc accaccgaag atccatacgg acttcttagc
     9241 gagatactgt ttcttctcta atacttctgc tgcatctggg catccagctg ctgctgcttt
     9301 ttctacctca gcgattaatg cctgagcatc aggtgtattt tcttttgtat tgtcttttgt
     9361 ttccatgaac ttagcaaatg ctgctttaaa ttcatcggat gctttatcgg atgctgccat
     9421 cttctctaat ttagcgatag cctggtcacg taaagtcttc tgtccaagat acataccaaa
     9481 gccgtgctct gcgttatcct cgaataagga gtttgcccaa gctggtccct gtttggaatc
     9541 tttgtttact gtatatggag ctgttgctgc aggaccaccc cagatggatg aacatcctgt
     9601 tgcgttggag atgtacatat gctctccgaa taactgagta atcagacgag cgtaagatgt
     9661 ctctgcacat cctgcacaag atccggagaa ctcaagtaat ggctggttga actgagatcc
     9721 cttaactgta gtatctgcag gagcacctgg ttttcttcca acagttgcaa ctaagtaatc
     9781 gaatactggc tgttctgctg cctggctttc ctgtggaacc atctttaatg cgcccttagc
     9841 tgcagcagga caaactgtga tacactcacc acatcccata cagtctaatg gagatacgct
     9901 cattgtaaat ttgtattcgc ttgcctttgg ctttgtatct gcaactttca tgttgtcagg
     9961 agctgcctta atttcgtctt cgcttactaa gaaaggacga attgtagcat gggaacatac
    10021 aaacgcacac tggttacact ggatacaagc ttctggattc cattctggaa cagatacagc
    10081 agtaccacgt ttttcgtatg cggaagcacc aagttcgaac tgtccgtcag cgttgtctac
    10141 gaatgtagat actggcaggc tgtcaccatc catgattccg ataggttcca tcattttctt
    10201 aaccatctta actgtctctg gacgtcctgt aagttcttta gcaggagcat cagcagctgg
    10261 gttagaccag gaagctggaa tctctacttt atgaacagca tctacaccag cgtcgatagc
    10321 tttgtagttc atctctacaa cagcgtcacc cttcttgctg taggacttct tagctgctgc
    10381 tttcatgaat tctactgctt cgtcgatagg catgatgttc gctaatttga agaatgcgga
    10441 ctgtaagatt gtgttagtac gtttacccat accaatctcg atagccttat caatcgcgtt
    10501 gattgtgtat aactgaatgt tgttgtcagc aatatacttc ttagctgctg caggcatatg
    10561 atgatctaat tcttcatcag accactggca gttgatcatg aagattccgc ctggtttaac
    10621 atcctgaacc atcttgtaac ctttaactac ataagatggg ttgtgacatg ctacgaagtc
    10681 agcctgatta atgtagtatg ggcttctgat tggattgtca ccaaaacgaa ggtgagaaat
    10741 tgtaatacca cctgtcttct tggagtcata ctggaagtat gcctgaatgt atttatctgt
    10801 gtggtcaccg atgatctttg tagagttctt gttagcacct acagtaccgt ctccaccaag
    10861 accccagaac ttacactcta ctgtaccagg agcagatgta ataggagctg gtttaacttc
    10921 tggtaaagat aagtttgtaa catcatccac gataccaatt gtgaaacggc tctttggagc
    10981 gtctttttca agttctttat aaatagcaaa tacagatgaa ggaggagtat ctttagaacc
    11041 taatccgtaa cgtccagctg taagaacgat atcgttaaga cctgcttctc taagagttgt
    11101 agcaacatca agatataaag gatctcctaa tgctccaggc tcttttgtac ggtcaagaac
    11161 agcgatcttc ttagctgtct taggaataac gtctaataat gcagaagata cccaaggacg
    11221 atataaacga actttgatta aaccaacctt ttcacctttt gctgttaagt aatcaattac
    11281 ttcttctgct acgtcacaga tagatcccat agcgatgatt acgcggtctg catcttctgc
    11341 accatagtag ttgaataaat cgtagttagt tcccagtttt tcgttgattt tgcccatgta
    11401 tttcttaaca acagctggta aagcttcgta aacagagtta caagcttctc tgtgctggaa
    11461 gaaaacgtca ccgttttcgt gagaaccacg catagctggg tgttctgggt taagagcatg
    11521 ctcacggaaa gctttaactg catccatgtt gcacatttct tttaagtctg cataatccca
    11581 tttttcgatc ttctgaatct catgagatgt acggaaacca tcgaagaagt tgatgaatgg
    11641 aactttacct tcgattgcag caagatgtgc tacagggctt aagtccataa cttcctgtgg
    11701 gttagtttct gccagcatag caaatcctgt ctgacgacat gcatatacgt cactgtggtc
    11761 accgaaaatg ttcagagact gtgtagcaac tgtacgtgca gatacatcaa atacacatgg
    11821 aagctgctca gctgcgatct tatacatgtt agggatcata agaagaagac cctgggatgc
    11881 tgtaaatgtt gttgtgatag caccagctgc aagagaaccg tgaacagtac ctgctgcacc
    11941 tgcctcagac tgcatctcac taacaactac ctggttacca aaaatatttt cctgtcctgc
    12001 tgctgcccac tggtcaacgg aatcagccat tggactagat ggtgtaatag gatagatagc
    12061 tgcaacatct gtatacgcat atgctacgtg agctgctgcg gtatttccat ccatagactg
    12121 ttttgctcta ggcattgatt attcctcctt gtcaaaagtt gtggtttatt ttaaattcga
    12181 cataatatta tcattttttt gaggtaatgt aaagcttatt cggaactgtt ccttctaaaa
    12241 tacaaaatct tgcccgaaac agccttttta tgccaatttt tccccttgac aacgtatttt
    12301 tccgagaaca attttaggtt aaaattgcta taaagccaac agttttgtat acaatataca
    12361 tatggcttat tttagatttt ttctcaataa ttttttgttg taattttagg attattcagg
    12421 attaaaattc taatattttt tcttcatttt ttaattattt tatgagattc ctctttgttt
    12481 tcaccattta tctccatctt ttaaaaataa caatttcgta attttacata atttaatcga
    12541 ctagaacgtg tttgaaaaat gctttctgca agatgtgtgt cacaatttgc gggagattgt
    12601 gcatgaatga gggcagcata acgggcggct acgtcaactg aatgaagcca acacaactct
    12661 ataggaaaac aggcacgtta tttgacaaaa tgtcaatgag acaattcacg aaaaacgact
    12721 ttttactcag aagtgatgaa aagaaaatta agtgggaatc cacggtaatt ccatattatc
    12781 tccctcacac tttcataaaa atatatctaa aaaacacaac ggcaatccct atacacaaaa
    12841 aaggtcccag cgcaaagcaa tcctttcgct tcgcacgctt tgtaatcagt agaaaaaatc
    12901 catataatcc tcctaaaagt aatcccgcac aagcagcaaa tatattccac tttatcccta
    12961 gtaacactcc acttgccgcc attagcttaa catctcctcc acccagtccg cctgaacata
    13021 aaattgcaag tatgaacatc ggaatactaa ccgaaaacac tcccaaaaag cgacttaaga
    13081 atgtaacttc ctggaaaaca aaaccactcc agattcctga aataaacaaa agtacattta
    13141 actgattcgg aattatcttg attttaaaat caattataga aataaccagt aaaatactaa
    13201 ctataacaat cattgtaatt accctcatat actccccctg gctcctgcta attgcagaat
    13261 ttttattaag tttactattt tacagaccct gtaacccaaa tactataatt atgaaaatcc
    13321 ctgcaatgga gttattaaca tgtgtttaat ctataaacca ttccaactga cagatttaac
    13381 ttgactcaaa aataattttt taaataactt tcattatttt ctcttgaact tttaaaagta
    13441 ttaaatttct atttgagtta ttttatacca tttatgtgtt tgtttttcca ttttatacca
    13501 tttttcttct agagtcaact atttatttac aaaattaaaa agaaattata tactaccttc
    13561 aggaggatac aaattaatat ggtcaaatta atcgaaacag tatacaattt tttatgggga
    13621 gatttactca ccgcaccctt acccggcggc ggaacactcc ccctttcact tttagtcatt
    13681 ttactaattc ctaccggagt gtatttcaca atccgtacaa agtttctgcc aatacgtctc
    13741 tttaaagata tggttggcgc acttttcgaa aaaaaagacg aagaacaaag cgcactttcc
    13801 gtcatccaga ctttgattgt ttccacagca actcgtgttg gaatgggcaa tctggtcggt
    13861 gtagttgccg caatttccgc tggcggagct ggtgctgttt tctggatgtg ggttactgcc
    13921 cttatcggtt cttccaccgc ttttatcgaa gcaactttat cacagattta taaagaaaaa
    13981 gaccctctat atggaggata tcgaggagga cctgcttact acattcatcg atattttgaa
    14041 gaaaaatccg gcaagaaaaa acgttatgta cttctttccg tactctttgc catttccggc
    14101 cttatatgct ggtgcggcat cagtcaggta gtaagtaatt ccgtagcatc tgcttttaaa
    14161 aatgcttttc acattccacc gatttacact acagttattc ttgtaatact tgccgcaatt
    14221 atcgtacttc gaaaaaatgc aaccgtaaaa gttttggata ttatcgttcc catcatggct
    14281 ggattttatt tactgattac attgtttatt atcatcacaa atatcacaca gctccctggt
    14341 gtatttgaac gaatcttttc tgaagctttt ggtttccgtc aggtagccgc cgggggattc
    14401 ggtgccgtcc ttatgaatgg aatcaaacga ggcctttttt caaacgaagc cggttctggt
    14461 tctgcccctt gcgcagccgc agccgctgtt gcagataatc ctgttaaagt cggattaaca
    14521 caggcgttag gcgtttttat tgacacgctt atgatctgca gttgtactgc tatgatcatg
    14581 ctccttactc caacaaagct cactgaagga ctcgttggaa tggatttatt acaaaaagca
    14641 atggaatatc atctcggctc attcggagta atattcattg ccataacgtt atggttattc
    14701 agtttttcta catttatcgg aatcttgttt tatgcacgct ccaacgtagc ttacctcttt
    14761 ggagataact ggttctctca aacagcttac aaagttcttg ctttagcaat gctttttgtt
    14821 ggaggacttg ctgcgtatac aattgtatgg gatttgggag atgtcggaat tggattgatg
    14881 acgatcttta acatcattat gttatatccg ttgtcgaaaa aggctctgaa tgctctgaaa
    14941 gaatatgaga agaagaaatt ctaagttgta ggattgagat aaacagacga gtccccccaa
    15001 tatgaatcct gattttactt cagcgaccac agtcagcccg aaaagagagc cgaaaaccaa
    15061 aaattttggg cgcggggcca aggtttggtg ggagcgcgta aaccaacaat aaaaaccccc
    15121 ccacaaaagt aaaaaaaata tggggtatgg tatcggttag gg
//
