GCA_934846195.1 - 3 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaMKCBKEGC_2 (original name was: gnl|Prokka|MKCBKEGC_2)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	ranthipeptide	1	19,764
Region 2.2	RRE-containing	120,988	141,251

gnlProkkaMKCBKEGC_4 (original name was: gnl|Prokka|MKCBKEGC_4)

Region	Type	From	To	Most similar known cluster		Similarity
Region 4.1	NRPS,HR-T2PKS	97,996	184,912	leucomycin	Polyketide	3%

Region	Type	From	To	Most similar known cluster	Similarity
Region 2.1	ranthipeptide	1	19,764
Region 2.2	RRE-containing	120,988	141,251
Region 4.1	NRPS,HR-T2PKS	97,996	184,912	leucomycin	Polyketide	3%

No secondary metabolite regions were found in these records:: gnlProkkaMKCBKEGC_1 (original name was: gnl|Prokka|MKCBKEGC_1); gnlProkkaMKCBKEGC_3 (original name was: gnl|Prokka|MKCBKEGC_3); gnlProkkaMKCBKEGC_5 (original name was: gnl|Prokka|MKCBKEGC_5); gnlProkkaMKCBKEGC_6 (original name was: gnl|Prokka|MKCBKEGC_6); gnlProkkaMKCBKEGC_7 (original name was: gnl|Prokka|MKCBKEGC_7); gnlProkkaMKCBKEGC_8 (original name was: gnl|Prokka|MKCBKEGC_8); gnlProkkaMKCBKEGC_9 (original name was: gnl|Prokka|MKCBKEGC_9); gnlProkkaMKCBKEGC_10 (original name was: gnl|Prokka|MKCBKEGC_10); gnlProkkaMKCBKEGC_11 (original name was: gnl|Prokka|MKCBKEGC_11); gnlProkkaMKCBKEGC_12 (original name was: gnl|Prokka|MKCBKEGC_12); gnlProkkaMKCBKEGC_13 (original name was: gnl|Prokka|MKCBKEGC_13); gnlProkkaMKCBKEGC_14 (original name was: gnl|Prokka|MKCBKEGC_14); gnlProkkaMKCBKEGC_15 (original name was: gnl|Prokka|MKCBKEGC_15); gnlProkkaMKCBKEGC_16 (original name was: gnl|Prokka|MKCBKEGC_16); gnlProkkaMKCBKEGC_17 (original name was: gnl|Prokka|MKCBKEGC_17); gnlProkkaMKCBKEGC_18 (original name was: gnl|Prokka|MKCBKEGC_18); gnlProkkaMKCBKEGC_19 (original name was: gnl|Prokka|MKCBKEGC_19); gnlProkkaMKCBKEGC_20 (original name was: gnl|Prokka|MKCBKEGC_20); gnlProkkaMKCBKEGC_21 (original name was: gnl|Prokka|MKCBKEGC_21)

Compact view

gnlProkkaMKCBKEGC_2 - Region 1 - ranthipeptide

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Location: 1 - 19,764 nt. (total: 19,764 nt) Show pHMM detection rules used

Region on contig edge.

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaMKCBKEGC_2 - Region 2 - RRE-containing

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Location: 120,988 - 141,251 nt. (total: 20,264 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaMKCBKEGC_4 - Region 1 - HR-T2PKS,NRPS

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Location: 97,996 - 184,912 nt. (total: 86,917 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

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Similar known gene clusters from MIBiG 3.1

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 97995 - 184912:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 97995 - 145327:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg4_102

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AMP-binding (457..845): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASFLGGVYK
Nearest Stachelhaus code(s):: Ile DALFMGGVYK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1479..1869): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMKNLGTVSK
Nearest Stachelhaus code(s):: Asp DMKDLGMVDK (53% 8Å match)
Stachelhaus code match:: 70% (weak)