LOCUS       gnlProkkaLEHIGABL_26   14482 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LEHIGABL_26.
ACCESSION   gnlProkkaLEHIGABL_26
VERSION     gnlProkkaLEHIGABL_26
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 22:47:16
            Original ID  :: gnl|Prokka|LEHIGABL_26
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14482
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14482
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[7710:7968]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7711..7968
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14482
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14482
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(2..1288)
                     /locus_tag="ctg26_1"
                     /transl_table=11
                     /translation="MAGIGIKLQKIYEKKTILAYLTGFGYSAVVTVAPMFVVIGTIMLM
                     SQLLGYENVGYARRGLFSGTLLYIFIFSLLTAAPFNAVLSRYMSDVIYEERYEDILPCY
                     DVGLLLNILLASLLGIPFCAWEHLVGHVNLIFVFTGFCGYIALVLVFYSMLYLSICKDY
                     QKISLYFLTGMAAALACALFFVKVCGREIVYSMLLSLTIGFFLTAVLEYATVKRYFKRN
                     SNRYRRVFSYFGRYWKLVVINFLYTLGLYIHNFVFWNTDLQMRVADTFVFAPTYDLATC
                     LAMFTNLSSTIIFITRVEMHFHTRYKAYSEAVIGGRWEDIKNTKDRMFRQLSAELMNLV
                     RIQFIISTAVYLLCVVVLPQYGFSGRVMQIYPCLAAGYFILFILYAEIIFLYYFNDLTG
                     ALLATLGFCLVTWAGSVLSAGGSDLWYGMG"
     CDS             complement(1303..2727)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 123.8;
                     E-value: 1.7e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_2"
                     /sec_met_domain="Glycos_transf_1 (E-value: 6.6e-24,
                     bitscore: 74.1, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRICIVAEGCYPYVVGGVSSWIHSMIKIFPEYQFVVLAIVANRSL
                     RGKFVYDLPENVVEVHELYLEDADWRPKELKRAARLKLNEREYAALRSLLMNQNVDWDT
                     LFSFFGEKEFSLNELLMGEDFFRAVQECYTVRYAGAVFSDFLWTMRSMYLPLFLTLGMR
                     LPRADVYHCVATGYAGVLGSMAKRRFGCRLLISEHGIYTREREEELIRADWVSGIYKNI
                     WIEQFKKMSKLAYDRADLVTSLYAHARELQIELGCPADKTSITPNGIDPARFDGLKRPE
                     AMEPDMVHIGAVLRVTPIKDVKTMIRAFAYAKRDVPNLKLWIMGPTEEDEEYARECFEL
                     VELMELPDVVFTGRVNVTEYLGGLDFTILTSISEGQPLTVLEGYAAKLPAIATDVGNCR
                     GLLYGEDDDFGEAGILTHIMNVKEIADAMVNLARHPVRRKQMGENGYRRVMAKYKISDM
                     QQTYRKIYETFENIDW"
     CDS             complement(2724..4601)
                     /locus_tag="ctg26_3"
                     /transl_table=11
                     /translation="MVSRRNYLTIAMMFVILLFMFQFTGVMKEQLSEYESNEYADDTTT
                     SFQRSDAFLAEQTSADACEVIYVGEAGGAEESVVKTWCSYRKRTFFCSSSLALLDSLQD
                     DALQVLVVDGSKVTSEEEVAVLRREAQMGVTVIFATLPQSSVIREYRDLRELLGIRAVI
                     ADEIPLAGMHLFSGFLLGGEEIYEVTEPGEEERQDMNPSVPWYTTGAGTKTYMVGTLSD
                     ETIEQTVDDEIRAQYVGMEEEAAKNSLLPAILWRNSVDTAKIFCVNGDYLADISAVGIL
                     DAMMGETYDYDIYPVINAQNLVIADLPAFVSENEEEMQKRYSQSAQAVYQEIVWPSLTS
                     IASRTGAKMTCMMTPQFTYTDEEEPDGENVTYYLKRLKEEHAEAGLSADSREGIPLSEK
                     IKQDQTFWQTYAPSYRFLSLYADGVKSIGEESALPAEIRTVALGSGASEAVGYLNENVT
                     LQPSTSSGIRHTFLDDFKVKCMETALGYSNITLDLYSVTYPEGDEDSWEKMSKKIAANL
                     GTYWKAYEAFDATTLTESDVRIRRFLALDYKQQRAGNVITLSLEHREDAAWFLLRLHGE
                     KVTEVAGGSFEEIEDGVYLILAEEDEVSVEVQTGETWQYQDGGKRGDGT"
     CDS             complement(4622..5539)
                     /locus_tag="ctg26_4"
                     /transl_table=11
                     /translation="MSRIETYFLLLVVLNLCITAAYVLWNEQHWREEPGKRTGGRIRAA
                     VMLLAPVIGPVFFVAGELARHLLFGQSADLEDVIFSKERVRTHFMADEEQERNVVPIEE
                     ALAISDRDSLRTLIMNVVRGDVTDSLGSLALALDSEDTETSHYAASVLRDVLNDFRQHA
                     QKLYRQMQKDGREAGDDACLLIEYMYVVLKQNVFHETEQRTFVDMFEEACELLYEKDYR
                     KLTAQYIEWLCELLLRLKEFGRMHYWCNRSRELYPDALSTYTCYLKMYFTQEKKTEFFR
                     ELDRLKASNIVIDRETLELIRTFS"
     CDS             complement(5536..7707)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 60.3;
                     E-value: 3.5e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_5"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.8e-13, bitscore:
                     39.2, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNILLVGSKCRFLQLLTDKLDKEGHRVFLLTAEDKSVRTSKKIFE
                     TYHFAYDNPCIREVLEGVRPDVTVFMGAYDTGFLWGKGSSTASAYTSGLFQLLMNETAG
                     NVGRFLYLSSEEVFGGEYTQDISCEENCAAYTVRAQAIAAGEELCHSYFNMGYETIVLR
                     LDHLYGEPLTGAEARDICARMSVEGLETGEIRVNPHNRVALLHYSDAVEFLYAVITAKK
                     MTYGVYQISSGETISARSAAEFVAAELEGVKVVEDTGRERMDPVLSNQRFTEEFGIRIV
                     HKPETEIGREAAYIRQHASSFVRTQSRKKGWSRFGERSREAVRAMIPFAENLLCFLPFF
                     LLNNWMAGSAYFQNIDFYLLYVLLFAITYGQQQATFSSILAVAGYLAVQMYQRSGFDVV
                     LDINTYIWIAQLLILGLVIGYMRDRLHAVEEEERHEVDFLSRQVEDISDVNGSNVRIKE
                     ILSNQIVNQNDSFGKLYEITSSLDKYEPSEVLFYAAEVLAKLMDSQDVAIYTVANHSYA
                     RLFSATSPKARMLGNSIHYVQMEELYEKLREKKVFINKTMDERYPLMADAIYSEDEMQL
                     ILMVWGIPWERMTLGQANMLTVIGYLIQNAVVRANRYLSALEQQRYIHGTRILEADAFV
                     SLVKAYLNAREKKLTECALVVFEESETSREEAAGVLSGMMRQSDYLGELPDGKMYALLA
                     NTSAEDAGMVVERFRSAGFPCRMKEEMEL"
     CDS             complement(7711..7968)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_6"
                     /sec_met_domain="PF05402 (E-value: 5.2e-13, bitscore: 38.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.4e-10,
                     bitscore: 29.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKNRYQLRCAAGKYWLLDMEQDGETYRPPLMLNESGAYIFRQYM
                     AGNTADKIAEELATMYGGTADDMRTDVMQFIRQMELQGIL"
     CDS             complement(8132..8890)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 88.9; E-value: 6.2e-27)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg26_7"
                     /transl_table=11
                     /translation="MEKLNVAIADDNERMLRLLGDIIESDDELNVVGVARDGEEAYHVI
                     KAKEPDVVLLDIVMPKLDGLGVLDRVSQDTSIKKHPAFIMISAIGQEKITEDAFARGAD
                     YYIMKPFDNDIVLSRIKNVRRPAAGRGAEVRKVNAYEKAEETKERNLEADVTDIIHEIG
                     VPAHIKGYQYLRDAIVMSVNDMDMLNSITKILYPTXXXXTRQPPAVWSGQSGMRSRWRG
                     AEARWIPLMRCSGIPSTTEKENRRIRSLSH"
     CDS             complement(8988..10448)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:diguanylate cyclase (Score: 139.5; E-value:
                     3.4e-42)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_8"
                     /transl_table=11
                     /translation="MEQQEHIQKLADEYYEEGRARFFDHKLEEAAMLVQNALHLYKKCD
                     DMLKYATALNLLGVIYGATGNETMAVDYLVEGLECAIDYQLNNITTLFYNNIGSRYQEL
                     GEHEKAIDYFLKSARELQNPTCIKEERYRSWALITYLNLAVSYYELNLYELSYKYLEQA
                     ERQLDEEVEEMYHYTVLIFKCRLLWQMGKGDYVYEYMEDLLASGEKDSNASDYLNDMKD
                     LCQLFRDMKEYEYWKQTISAVETYTIDQKSVFFQLFLTELWMDYYQTVGNEERYVELCV
                     AHADLYKRQKAIDAKDRATAIDIKVQLREKEAERKRVETMSVTDALTGLGNRYSLEREA
                     VHIIRDAGGERITVGVLDIDCFKQLNDTYGHIQGDRCLKVVADILKEAVMDCGHVYRFG
                     GDEFVMLFPAGMENRIEGIAEAILQKIAEAGIANEYSVVQPNLTISQGYACFVPEGTES
                     GARLIEHADKALYYVKRNSRNAYYIIRE"
     CDS             complement(10531..11751)
                     /locus_tag="ctg26_9"
                     /transl_table=11
                     /translation="MRHKFYFLIQQITWVVFLFLTLFAVKTFERALPDEIYVPFGEKAD
                     YRFGVPVSVTLKDDSEEVFYRLNGQEDAVAEPPFYTVTCKLFGIFPVKDVKVMMVDRQE
                     VTAGGEAIGIYVKTDGILVLGTAKIADAWGNECSPAQNLVQSGDYIVSVNGETVCGKEE
                     LMDKIDSYGSGREIIGVMRKGEYVEVSMNPVKGETGKYRLGIWVRDDLAGVGTLTYYRQ
                     DGSFGALGHAVSDGDTGVQMSLSEGYIYETKIVSIQKGKNGVPGELAGIIDYGKSHCMG
                     SITENSPLGIRGMLNDTAGELEGEVYEVAYKQDIVLGKAYIISEVSGERAEYEIEIESL
                     DYSGDEENKGILFKVTDERLLGLTGGIVQGMSGSPIIQNGKMIGAVTHVFVSDASMGYG
                     IFIEKML"
     CDS             complement(11859..13562)
                     /locus_tag="ctg26_10"
                     /transl_table=11
                     /translation="MLQSLHVKNLALIDEAEVDFTRGLNILSGETGAGKSIIIGSINLA
                     LGEKVQKEMLREDPQTGEFAPALVELVFTVENGQERQKLEALEVYPEDDQVILSRRIVG
                     GRGTARVNGQSMPASAVREIAAILIDIHGQHEHQSLLSKRRHLEILDAYVGETLTEKKK
                     ALAETYRSYKKLVEEEKNAGIDGAEREREVSFLEYEIREIEEAGLREGEDEELENEYRR
                     FSNGQKIVNAVNGAYSNTGGESDCASELTGRAVRELSSVSGYDEKLAELERELLEIDGL
                     LSDFNRELADYVENMEYDEETFYQVEKRLDEVNHLKSKYGSTIPDVLLALEEKQERLMQ
                     LKDYDTYLAGLKEEIARTKKVLEKQSSEVSAMRKEAAERLTAAVTQALLDLNFLDVRFT
                     MNFERMAEYTANGFDDAEFLISTNPGEPLKPLGKVASGGELSRIMLAIKTVLADEDAVE
                     TLIFDEIDSGISGRTAQMVSEKMNVLGRSHQIICITHLPQIAAMADSHYLIQKSVQNQT
                     TVSTIRRLSEEESIQELSRMLGGVEITETVKESAREMRALAKSKKSGFEK"
     CDS             complement(13598..14050)
                     /locus_tag="ctg26_11"
                     /transl_table=11
                     /translation="MKTKRQAKMLELIKRNDIETQEELSDYLEREGYQVTQATVSRDIR
                     ELKLTKVAMSNGRQKYVALQETDENLSQKYVRVFHDGFVSMDMAQNILVIKTVSGMAMA
                     VAAALDAMHMHEIVGCIAGDDTIMCAIRSVDDTVAVMNRLKKLVED"
     CDS             complement(14070..14480)
                     /locus_tag="ctg26_12"
                     /transl_table=11
                     /translation="MVVSLIVYVNGEYLHTFRADGIIVSTPTGSTGYNMSAGGPIVDPK
                     AQMILITPINAHNLNSRSIVIGAEDEVVVEIGRRRSQKDETLEVSFDGDTAARLVVGDK
                     FSIRKASDTTRILKLSNKSFLEILSKKMQVYT"
ORIGIN
        1 gccccatgcc gtaccacagg tcactcccgc cggcagaaag cacgcttccc gcccacgtca
       61 ccagacaaaa gccgagggtt gccaaaagcg cccctgtcag atcgttaaag tagtacagaa
      121 aaataatttc tgcatacaga ataaataata taaaatatcc ggcggcaaga caaggataga
      181 tctgcatcac tcttcccgag aacccgtact gcggaagcac caccacgcag agcagataca
      241 ctgccgtcga gatgataaac tgtatgcgca ccagattcat aagctccgca gaaagctgcc
      301 ggaacattct gtcttttgta tttttgatat cttcccatct tcctccgata accgcttccg
      361 aatacgcctt gtaacgtgtg tggaaatgca tctctacccg cgtgataaaa atgatggtcg
      421 acgacagatt cgtaaacatc gccagacagg ttgccagatc atacgtcgga gcaaagacaa
      481 acgtatccgc cacgcgcatc tgtaaatccg tattccagaa cacaaaatta tgaatataca
      541 gaccgagggt atacaaaaaa ttgatcacca ccagcttcca gtacctgcca aaatacgaaa
      601 aaactcttct gtaccggttg ctgttcctct taaaataccg cttcaccgtg gcgtattcca
      661 acaccgccgt aagaaagaat ccgatcgtga gggaaagcag catactgtag acaatctccc
      721 taccgcatac ttttacaaaa aagagggcgc aggcgagtgc cgccgccatc ccggtcaaaa
      781 agtacagcga tatcttctga taatccttac agatggagag gtaaagcatc gaataaaaca
      841 cgagaaccag tgcgatataa ccgcaaaatc cggtaaacac aaaaatcagg ttgacatgtc
      901 ccacaagatg ttcccatgcg caaaacggaa ttccgagaag acttgccagc agaatgttta
      961 aaagcagccc cacatcgtag cagggcagaa tatcctcata gcgctcctca tagatgacat
     1021 ccgacatata gcgggacaac accgcattaa aaggcgccgc cgtcagaagc gaaaagataa
     1081 agatgtaaag cagcgttccg gaaaacagtc ctcttctcgc atatcccaca ttctcatatc
     1141 ccaggagctg actcatgagc atgatcgttc cgatcacgac aaacatcggt gcgaccgtca
     1201 cgaccgcact gtagccgaat ccggtcagat atgcaagaat cgtttttttc tcatatattt
     1261 tctgaagctt gattcctatt cctgccacag tctctctccc ttctaccagt ctatgttctc
     1321 aaacgtttca taaatcttcc ggtacgtctg ctgcatatcc gaaatcttgt actttgccat
     1381 cacacggcgg taaccgtttt ctcccatctg ttttctgcgg accggatgtc tggcaagatt
     1441 caccatggca tccgcaattt ccttcacatt catgatgtgc gtcaaaattc ccgcctcgcc
     1501 aaaatcatcg tcctcgccgt acaacagtcc gcggcagttt ccgacatcgg ttgctatcgc
     1561 cggaagcttc gccgcatagc cctccagaac cgttaacggc tgcccctcgc tgatactggt
     1621 cagaatggta aaatccagtc cgccgagata ttccgtcaca ttcacccttc cggtaaacac
     1681 cacatccggc agttccatca gctccaccag ctcaaaacat tctctcgcgt attcctcgtc
     1741 ttcttccgtc ggccccatga tccataattt taagttaggc acatcgcgct ttgcatacgc
     1801 aaacgcccgg atcatggtct tgacatcctt gatcggcgtc acgcggagta ccgcaccgat
     1861 gtgcaccata tccggctcca tcgcttccgg acgcttcaaa ccgtcaaacc gcgccggatc
     1921 aatcccattc ggggtaatgc tcgtcttatc cgcaggacat cccagttcga tctgaagctc
     1981 tctcgcgtgc gcgtaaaggc ttgtcaccag atccgccctg tcataggcaa gcttcgacat
     2041 tttcttgaac tgctcaatcc agatattctt atagatgccg gacacccagt ccgcacggat
     2101 cagttcttcc tcgcgctccc tggtgtagat tccatgctcc gagatcagaa gcctgcagcc
     2161 aaacctgcgc tttgccatgc tgcccagcac gcccgcatat cccgtcgcca cacagtgata
     2221 cacatccgcc ctcggcagcc gcatgccaag tgtcagaaac agcggaaggt acatggagcg
     2281 catcgtccag aggaaatcag aaaacaccgc ccccgcatac cgcaccgtat aacattcctg
     2341 caccgcccgg aaaaaatcct cccccatgag aagttcattc aaagagaatt ccttctcccc
     2401 gaaaaaggag aacagggtat cccagtctac attctggttc atcaacaggc tccgcagtgc
     2461 ggcgtactcc cgctcattta acttcagtct ggctgctctt ttaagttctt ttggccgcca
     2521 gtctgcatcc tccagataca gttcgtgcac ttccaccaca ttctccggga gatcgtagac
     2581 aaactttccg cgcagcgaac ggttcgccac aatcgccagc acgacaaact ggtactccgg
     2641 aaatattttt atcatactgt gtatccagct cgatacaccc ccgacaacat agggatagca
     2701 tccctctgcc acaatacata ttctcatgtg ccgtcaccac gctttccgcc gtcctgatac
     2761 tgccatgttt ccccggtctg cacttccacg gagacctcat cttcctctgc aagaatcagg
     2821 tagacgccgt cttctatctc ttcaaagctt ccgcccgcaa cttctgtgac tttctctccg
     2881 tgcaggcgca gcagaaacca tgccgcatcc tcccggtgct ctaaggaaag cgtaatcaca
     2941 ttgcccgcgc gctgctgctt atagtcaagt gccagaaatc tgcggatgcg cacatcactc
     3001 tctgtcaggg tggttgcgtc aaacgcttca tacgctttcc agtaggtgcc caggtttgct
     3061 gcgatcttct tggacatttt ctcccaggaa tcctcgtccc cttccggata agtcacgcta
     3121 tagaggtcga gtgtgatgtt ggaatagccg agcgccgtct ccatgcattt cactttaaaa
     3181 tcatccagaa acgtatgccg gattccggaa ctcgtcgacg gctgcagtgt gacgttctca
     3241 ttgagatacc ccaccgcctc gctggcacct gatccgagcg caaccgttcg gatttctgcc
     3301 ggaagggcac tctcctcccc gatgctcttt actccgtccg cgtagaggga taaaaaccgg
     3361 taggacggcg cataggtctg ccagaacgtc tgatcctgct ttattttttc tgagagtggg
     3421 atcccttccc tgctgtctgc ggacagcccc gcctccgcgt gctcctcctt cagacgtttc
     3481 agatagtagg tgacgttctc tccatccggc tcttcctcat ccgtatacgt aaactgcggc
     3541 gtcatcatgc aggtcatctt tgcccccgtc cgggaggcaa tggaggtcag cgacggccac
     3601 acaatttcct gatacactgc ctgtgcggac tggctgtagc gcttctgcat ctcctcctcg
     3661 ttctcggaga cgaacgccgg cagatctgca atcacaagat tctgtgcgtt gatcaccggg
     3721 tagatatcgt aatcgtatgt ctcccccatc atggcgtcca gtattccaac agcgcttatg
     3781 tctgcaagat aatccccgtt cacacagaaa atctttgccg tgtccacact atttctccag
     3841 agaatggcag gcagaaggct gttttttgcc gcctcttcct ccattcccac atactgtgcc
     3901 cgtatttcgt catccaccgt ctgttcgatc gtctcatcgg acagcgtgcc gaccatatag
     3961 gtcttggttc ccgcgccggt cgtataccag ggaacagaag ggttcatgtc ctgacgctcc
     4021 tcctccccgg gttccgtgac ctcatagatc tcttccccgc cgagcagaaa gccggaaaac
     4081 agatgcatgc ccgcaagtgg tatctcatcc gcaatcaccg cgcggattcc gagaagctcc
     4141 cttaaatccc ggtactccct tatcacagag ctctgcggca gggttgcaaa aatcacagtc
     4201 acacccattt gtgcctctct gcgaagcacc gccacctctt cttccgacgt caccttgctg
     4261 ccgtccacca ccagcacctg cagtgcatca tcctgcaggc tgtcaagcag tgcgagggag
     4321 ctgctgcaaa aaaacgtccg cttgcggtag ctgcaccatg tctttaccac ggattcctcc
     4381 gctccccctg cttcgcccac atagatcacc tcgcaggcgt cggcagatgt ctgttctgcc
     4441 agaaatgcat ccgaccgttg aaaggatgtt gtggtatcgt ctgcatattc gttgctctca
     4501 tattcactta actgttcttt catgacgcct gtaaactgaa acataaaaag cagaatcaca
     4561 aacatcattg caatcgtcag ataatttctg cgtgatacca tgtcatttcc ttcctgccgg
     4621 actaactgaa cgtccggatc agctctaacg tctccctgtc aatgacgata ttggacgctt
     4681 tcagccgatc cagttcccgg aaaaattcgg ttttcttctc ctgcgtaaaa tacattttca
     4741 aatagcaggt gtacgtggaa agcgcatccg gatataattc ccggctccgg ttgcaccagt
     4801 aatgcatccg cccgaattcc tttaagcgga gcagcagttc acacagccat tcgatgtatt
     4861 gcgcagtgag tttccggtaa tctttttcat agagaagttc acacgcctcc tcaaacatat
     4921 ccacaaatgt ccgctgttcg gtctcgtgaa aaacattctg ttttaagacg acatacatgt
     4981 actcgatcag aaggcaggca tcatcccccg cctctctgcc gtccttttgc atctgccggt
     5041 agagtttctg tgcatgctgc ctgaaatcgt tgagcacatc ccgaagcacc gacgccgcat
     5101 agtgggaggt ctcggtgtcc tcactgtcaa gtgccagcgc cagcgatccg agagagtccg
     5161 tgacatctcc tctgaccaca ttcataatca gtgtgcgcag actatcccgg tcggaaatcg
     5221 ccagtgcctc ctcgatcggc accacattcc gctcctgctc ctcatccgcc ataaagtgtg
     5281 ttctgacacg ctccttactg aaaataacat cttccagatc cgccgactgt ccgaataaaa
     5341 gatgccgcgc gagttctccc gccacaaaga agacgggacc gatcaccggt gccaaaagca
     5401 taaccgccgc gcggattctt ccgccggtgc gctttccggg ctcttctctc cagtgctgct
     5461 cattccacag gacatacgcc gccgtgatgc acagattcaa taccacaagc agcagaaaat
     5521 acgtttcgat cctgctcata gttccatctc ctctttcatc ctgcacggaa agcctgcgct
     5581 cctaaaacgc tccacaacca ttcccgcatc ctctgcgctc gtgttggcaa gcagtgcgta
     5641 catctttccg tcggggagct ctccgagata atcgctctgg cgcatcatgc cagaaaggac
     5701 gcctgcggct tcctccctgg aggtctcact ctcctcgaaa acgacgagcg cacactccgt
     5761 cagcttcttc tccctggcgt taagataagc cttcaccagc gaaacaaacg cgtccgcctc
     5821 caaaattctg gtgccgtgga tatagcgttg ctgttctaac gccgagagat aacggttggc
     5881 gcgcacgacc gcgttctgaa tcagatagcc gatcacagtg agcatattcg cctgcccgag
     5941 tgtcattctc tcccacggga ttccccacac catcagaatc agctgcatct cgtcctccga
     6001 ataaatggcg tccgccatca gcggatagcg ctcatccatg gttttgttga tgaatacttt
     6061 tttctcccgc agcttttcat agagttcttc catctgcaca tagtgaatgg aatttccgag
     6121 catgcgtgcc ttcggcgaag ttgccgagaa cagacgcgca taggaatggt ttgccaccgt
     6181 atagattgcg acatcctgac tgtccatcag ctttgccagc acctctgcgg catagaacag
     6241 cacttcactc ggctcgtact tgtccaggct ggacgtgatc tcatacagct ttccgaagct
     6301 gtcgttctgg ttgacgatct gatttgacag aatctccttg atgcgcacgt tgctgccgtt
     6361 gacatccgag atgtcctcca cctgtctgga gaggaaatcc acctcatggc gctcctcctc
     6421 ctccaccgca tgcagccggt cacgcatata gccgatcaca agtcccagaa tcagcagctg
     6481 tgcaatccat atgtacgtgt tgatgtccag caccacatca aaaccgctcc gctgatacat
     6541 ctgcaccgca agataccccg ccaccgcaag tatcgaggag aatgtcgcct gctgctgtcc
     6601 gtaggtaatg gcgaacagta gcacatacag aaggtaaaaa tcaatgttct ggaaatacgc
     6661 actccccgcc atccagttat ttaacaggaa aaacggaagg aaacaaagca gattctccgc
     6721 gaatggaatc atcgctctta cggcctctct cgaccgctct ccgaaccggc tccatccctt
     6781 ttttctgctc tgtgtccgca caaaggaaga tgcgtgctgc cggatgtacg ccgcctccct
     6841 gccgatctca gtctctggct tatgtacaat gcggattccg aactcctccg taaatcgctg
     6901 gttggacaaa accggatcca tccgctctct tccggtgtcc tctacgactt tcacaccttc
     6961 cagttccgcc gccacaaact ccgctgcgct tcgcgcggaa atcgtctctc cggaagaaat
     7021 ctgatagacg ccgtacgtca tcttttttgc cgtaatcacc gcatacaaaa attcgacggc
     7081 atccgaatag tgtaacagcg ccacacggtt gtggggattt acccggatct caccggtttc
     7141 cagcccctcc acactcatgc gggcgcagat atcacgcgct tccgccccgg taagcggttc
     7201 cccgtagaga tgatccagcc tcagcacgat cgtctcatag cccatgttaa agtaactgtg
     7261 gcagagttcc tctcccgccg caatcgcctg cgcgcgtacc gtataagccg cacagttttc
     7321 ctcgcacgaa atgtcctgtg tatactctcc cccgaagact tcctccgacg agagatacaa
     7381 aaagcgtccc acattaccag ccgtctcatt catcagcagc tgaaacaggc ctgaagtgta
     7441 cgccgacgcc gtgctgctcc ccttccccca gagaaagcct gtatcatagg cgcccataaa
     7501 gactgtcaca tccggacgca ctccctcaag cacctctctg atgcacggat tgtcgtatgc
     7561 aaaatgatac gtctcaaata tctttttgga cgttctgacc gatttgtctt ctgccgtcag
     7621 caaaaacaca cggtgccctt ctttgtccag tttgtccgtc aaaagctgaa ggaagcggca
     7681 tttgcttccc accaataata tattcatcgt ttacaagatc ccctgtagtt ccatttgtct
     7741 gataaactgc atcacatctg tccgcatatc gtctgcggtc cccccgtaca tagtggcaag
     7801 ctcctccgcg attttatccg ccgtgtttcc tgccatatac tgcctgaaga tataagcccc
     7861 gctctcattt aacatgagcg gcggccgata cgtttctcca tcctgctcca tatctaacag
     7921 ccagtatttt cctgccgcgc acctgagctg atacctgttt ttctgcatct gccatcctcc
     7981 gaaaaatcat cgtataatta tagcacatct gacgctcaaa aggaaccggt tatccgaaaa
     8041 tgaggacata ctcttcttcg gctttgcgcc tcctgaaaaa tatgtcctca tcgttaatgc
     8101 atcttatatt ccagacgtat ccggtcggta atcagtgcga taaactccga attcgtcggt
     8161 tttccttttc cgttgtggat ggtatacccg aacatctcat caatggtatc catcttgcct
     8221 ctgctccacg ccacctcgat cgcatgccgg attgcccgct ccacacggct ggaggttgtc
     8281 tggtannnnn nnnnntcgtg ggataaagaa ttttcgtgat cgagttgagc atatccatgt
     8341 cattgacgga catgacaatc gcatcccgca gatactgata ccctttgata tgcgccggaa
     8401 ctccgatctc gtgaataata tcggtgacat ccgcttccag gttgcgctcc tttgtctcct
     8461 ccgccttctc ataggcattg accttgcgca cttccgcacc gcgtcccgcc gcaggtcttc
     8521 tcacattctt gatgcggctt aacacgatat cattgtcaaa cggcttcata atgtaataat
     8581 ctgcgccgcg cgcaaacgca tcttccgtga ttttctcctg accgatcgcg ctgatcataa
     8641 taaacgccgg atgttttttt atggaggtgt cctgactcac gcggtctaaa acccccaatc
     8701 cgtcaagctt cggcatcaca atgtcgagca gcacgacatc cggttctttc gcctttatca
     8761 catggtatgc ttcctcgccg tcgcgggcga ctcctacaac attcagttcg tcatcacttt
     8821 cgataatatc ccctaataat cgcagcattc tctcattatc atctgctatt gcaacattca
     8881 gtttttccat tttagcccct cctgtgacaa aactctttgc ttactgatga tactgattcc
     8941 aacgcaagaa aatttgtcga agctagtcgt caactgaagt atatacatca ttcgcgtatg
     9001 atataatatg cgtttctgct gtttctcttc acatagtaaa gcgccttgtc cgcgtgctca
     9061 atcagacgcg ctccgctctc tgtgccctcc ggcacaaagc aggcataccc ctgggagatg
     9121 gtaagattcg gctgcacaac cgagtactcg tttgcgattc ccgcctccgc aatcttctgc
     9181 aggatcgcct ccgcgatccc ctcgatccga ttctccatcc ctgccggaaa caacatcacg
     9241 aactcatccc cgccaaaccg gtagacatgt ccgcagtcca tcactgcctc cttcagaata
     9301 tccgccacca ccttcaggca gcggtctccc tgaatatgcc cgtaggtatc gttcagctgc
     9361 ttaaagcagt cgatgtccaa aacgccgacc gtgatccgct caccgcccgc atcccttatg
     9421 atatgcaccg cctcacgctc aagagaatag cggttcccca gcccggtcag cgcatccgtc
     9481 acagacatag tctccacgcg cttgcgctcc gcctcttttt cccgcagctg aaccttgatg
     9541 tcgatcgctg tggcgcggtc cttcgcatcg atcgctttct ggcgcttata cagatccgca
     9601 tgtgccacac acagttccac atagcgctct tcgttcccca cagtctgata gtagtccatc
     9661 cacaattccg tcagaaacag ctggaaaaag acggatttct gatcgatcgt ataggtctcg
     9721 accgcagata tggtctgctt ccagtattca tactctttca tgtcgcggaa cagctgacac
     9781 agatccttca tatcgttcag ataatccgac gcattgctgt ctttttcacc gctcgccaga
     9841 aggtcctcca tgtactcata cacatagtcc ccctttccca tctgccagag cagcctacat
     9901 ttgaagatca gtaccgtata atgatacatc tcctccactt cctcgtcaag ctgccgctct
     9961 gcctgctcta aatatttgta ggaaagctcg tacaggttca gttcgtagta ggagaccgcc
    10021 agattcaggt aggtaatcag agcccaggaa cggtagcgtt cctccttgat gcaggtcgga
    10081 ttctgcagtt cccgcgccga ctttaagaaa tagtcgatcg ccttctcatg ctctcccagc
    10141 tcctggtacc tggagccgat attgttataa aagagtgtcg tgatgttatt tagctggtaa
    10201 tcgatcgcac actcaagtcc ttcgaccaga taatccaccg ccatcgtctc gttccccgtg
    10261 gcgccgtaga tcactccgag cagattgagc gctgtggcgt attttaacat gtcgtcgcac
    10321 ttcttgtaga gatgaagcgc attctgtaca agcatcgccg cttcctccag cttgtggtca
    10381 aagaatctgg ctctaccctc ttcgtagtat tcatctgcca gtttttgtat atgttcctgc
    10441 tgttccattc cgtcttccgt ccttaaagcc aacaatactg actgtagtat accataagta
    10501 ccagacgttg taaaagtttt tgtcgtacaa tcacaacatt ttctcaataa agattccgta
    10561 ccccatcgac gcatccgaca caaacacatg cgtcaccgcc ccgatcatct ttccgttctg
    10621 gataatcgga ctgccgctca tcccctgtac gattcctccg gtcaggccta aaagccgctc
    10681 atccgtgact ttaaaaagga ttcccttgtt ttcctcatcc ccactgtaat caagactctc
    10741 tatctcgatc tcatactccg cgcgctcccc ggacacctcc gagatgatgt aggcttttcc
    10801 aagcacaatg tcctgcttat aagccacctc gtagacttct ccttccagtt ctcccgccgt
    10861 atcatttaac atgccgcgga tgccaagcgg cgagttctcc gtaatgcttc ccatgcaatg
    10921 cgatttcccg tagtcaatga tccccgcaag ttcgcccggg acgccgttct tccccttctg
    10981 gatgctgacg attttcgtct cgtaaatata tccttccgac aggctcatct gcacgccggt
    11041 gtcgccgtcg ctcaccgcat gtccgagtgc gccaaagctg ccgtcctgcc tgtagtaggt
    11101 cagtgttccg accccggcaa gatcatcccg cacccagatt ccaaggcggt attttcccgt
    11161 ctcgcctttg accggattca tggatacttc cacatactcc cccttccgca tcactccgat
    11221 gatctcacgt ccgctgccgt agctgtcaat cttgtccatc agctcctctt tcccgcacac
    11281 cgtctccccg ttcacgctca caatataatc cccgctctgc accagattct gcgccgggct
    11341 gcactcattg ccccacgcat ccgcaatctt tgcagtgccg agcaccagga ttccgtccgt
    11401 cttcacatag ataccgatcg cctcgccgcc cgcagtcacc tcctgtctgt cgaccatcat
    11461 caccttcacg tcttttaccg ggaaaatgcc gaacagcttg caggtaacgg tataaaaagg
    11521 gggctccgcc acggcatcct cctgcccgtt caagcggtag aacacttcct cgctgtcgtc
    11581 ctttaacgtc acgctcaccg gaacgccaaa ccggtaatcc gccttttccc cgaacggaac
    11641 gtagatctca tccggcagtg cccgctcaaa agtctttacg gcaaacagcg tcaaaaacaa
    11701 aaaaacaacc cacgtgatct gctgtatcaa aaaataaaat ttatgtctca tatctgcccc
    11761 cataccattt tctgtaaccc aaaggccgcc acacaacaaa aaagaagata ccatggtatc
    11821 tcatacctgt ggtatcttct tttattatgt gaatattttt acttttcaaa ccccgatttt
    11881 ttgctttttg caagcgcgcg catctctctc gcactctctt ttaccgtctc cgtgatctcc
    11941 acgcctccaa gcatacggga aagctcctgt atgctctcct cctccgacag tctgcggatc
    12001 gtggaaactg tcgtctgatt ctgtacggat ttctggatca ggtaatggga atccgccatc
    12061 gccgcaatct gtggaagatg tgtgatacag ataatctgat gtgaccgtcc cagcacattc
    12121 atcttctcgg aaaccatctg cgccgtccgt ccgctgattc cgctgtcaat ctcatcgaaa
    12181 atcagcgtct ccaccgcatc ctcatccgct aacaccgtct tgatggcaag catgatacgc
    12241 gaaagttctc ctcccgacgc tacttttccg agcggtttta acggctcgcc cgggttcgta
    12301 gaaatcaaaa attccgcatc gtcgaatccg ttcgccgtat actctgccat gcgctcaaaa
    12361 ttcatcgtaa aacgcacatc aaggaaattc agatccagta gcgcctgcgt aaccgccgcg
    12421 gtaagccgct ctgccgcctc cttacgcatt gcggacacct cgctgctctg cttctctaag
    12481 acttttttgg tccgcgcaat ctcttcctta agaccggcaa gatacgtgtc atagtcctta
    12541 agctgcatca ggcgttcctg cttctcttct aatgccagaa gcacgtccgg gatcgtgctg
    12601 ccgtatttgg atttcagatg atttacctca tcgagacgct tctccacctg gtagaacgtc
    12661 tcctcatcgt actccatatt ctcgacataa tcggcaagtt cccggttgaa atcgcttaac
    12721 agcccgtcga tctcaagcag ctcacgctcg agttcggcaa gtttctcatc gtatccggag
    12781 actgacgaga gttcgcgcac cgcccttccg gtcagttccg acgcacagtc cgattcgccg
    12841 ccggtattgc tgtatgcacc gtttacggca ttcacaatct tctgtccgtt ggaaaaccgg
    12901 cggtactcat tctccagttc ctcgtcctcg ccttcccgaa gtcctgcctc ctcgatctca
    12961 cggatctcgt actccaggaa cgaaacctcc cgctcgcgct ctgcgccgtc tatgccggca
    13021 tttttctctt cctccaccag ctttttgtag ctgcggtaag tctctgcgag cgccttcttt
    13081 ttctctgtca gcgtctctcc cacataggca tccagaatct ccaaatgtct gcgctttgag
    13141 agaagcgact gatgctcatg ctgaccgtga atgtcaatta aaatcgccgc gatctcgcgc
    13201 accgcggatg ccggcatact ctgaccgttg acgcgcgccg ttccccttcc gcctacgatt
    13261 ctgcggctta ggatcacctg gtcatcttcc ggatagacct cgagcgcctc cagcttttgc
    13321 cgttcctgcc cgttctccac cgtaaatacc agttctacca gcgccggagc aaactccccg
    13381 gtctgcggat cttctctcaa catttccttt tgcacttttt cacccagcgc cagattgatc
    13441 gaaccgatga tgatggactt acccgcaccg gtctctcccg agaggatatt gagtccccgg
    13501 gtaaaatcca cctccgcctc gtcaatcagc gccagatttt tcacatgcag actttgtaac
    13561 atagaatctc cttctactct ccccaaaaga atcccgtcta gtcttccaca agctttttca
    13621 agcggttcat caccgcaacg gtatcatcca cactgcggat cgcgcacatg atggtgtcat
    13681 cccccgcaat gcagcccacg atctcgtgca tatgcatggc atctaacgca gccgccaccg
    13741 ccatcgccat acccgagaca gtcttaatga ccagaatatt ctgcgccata tccatggata
    13801 caaatccgtc gtggaacacg cgcacatatt tctgcgacag attttcgtcc gtctcctgca
    13861 gcgcaacgta tttctgcctg ccgttgctca ttgcaacctt ggtgagcttt agttcccgga
    13921 tgtccctgga aaccgtcgcc tgtgttacct gatagccctc acgctccaga taatccgaca
    13981 gttcttcctg tgtttcaatg tcatttctct tgatcaattc cagcattttc gcctgtcgtt
    14041 tggttttcat tctgccctcc gtttcccgct tatgtgtata cctgcatctt tttgcttagg
    14101 atctcgagaa agctcttgtt gctcagcttt aagatccttg tcgtgtccga agccttccgg
    14161 atactgaact tatctcccac cacaagtctt gcggcggtat ccccgtcaaa actgacctcc
    14221 agcgtctcat ccttctgtga gcgccttctg ccgatctcaa caaccacttc gtcctccgca
    14281 ccgatcacaa tactgcgtga attgagatta tgcgcattga tcggcgtaat taaaatcatc
    14341 tgtgccttcg gatccacgat cggtccgcct gccgacatat tgtagccggt agaaccggtc
    14401 ggcgtcgaca caatgattcc gtccgcccga aacgtatgca gatactcccc gttcacatag
    14461 acgatcaggc tgactaccga ca
//
