LOCUS       c00008_gnlPro..        15818 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IFFOJIKN_8.
ACCESSION   c00008_gnlPro..
VERSION     c00008_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:15:47
            Original ID  :: gnl|Prokka|IFFOJIKN_8
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 23500
            Orig. end    :: 39318
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15818
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[33500:36686]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13186
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15818
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15818
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(513..1262)
                     /locus_tag="ctg8_26"
                     /transl_table=11
                     /translation="MKLAGKTDVGRVRQDNQDDYRAGELPGDAAWALVCDGMGGARGGR
                     EASQCACSVIERCFQEQYNQCIPGEEETFLKKALLSANRYVFQKALREESLAGMGTTAV
                     CALVRGGKAYLSHAGDSRAYLYRDGKLAQLTHDHSYVQELVDCGTITQEQAEHHPQKNI
                     ITRALGVDYRLEPEFTTVALQAGDVLLLCTDGLTNAVPTEQLEQLLRSGSFYDLPDVLI
                     RTANENGGPDNITALLVGVEPMEVRHG"
     CDS             complement(1279..2319)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_27"
                     /sec_met_domain="Radical_SAM (E-value: 2.2e-19, bitscore:
                     61.9, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKRCISSLTLAELTAELKALGQPGFRAKQIFHWVHQKLVTEFS
                     AMTDQPKTLLAKLEETFYIAAPQIERRQEAKDGTVKYLLRMADGNCIETVVMRYHYGNT
                     VCVSTQVGCRMGCRFCASTQAGRVRNLEAGEICSEIYTAQKDIGERISHIVLMGIGEPL
                     DNFDEVMRFLENITSPEGVNIGMRNISLSTCGLVPKIDQLAEKKLQLTLSISLHAPTNQ
                     IRSSMMPVNDAYPVEQLIQTVRRYQETTGRRVSFEYSMVRGVNDSDVCAKQLADLIRGM
                     GAHVNLIPINPVDGSPYSATDAANVRRFQQKLESLGVNATVRRRLGSEISAACGQLRRD
                     EMNGKA"
     CDS             complement(2361..3692)
                     /locus_tag="ctg8_28"
                     /transl_table=11
                     /translation="MAANPRAAAVAALVRQEQDGFSNLVLDAEIKRQNLEGRDKAFASA
                     IFYTVLEHRGTLDYILEQFLPKGLAKLDAPVREILRAALAQARYMQVPVSAAVNEAVKL
                     TRTFKKSSASGLVNAVLRKACGYDLDAAVFTDEIQRLMVLGSAGRDVAEFLHKNYPDEA
                     LGILTYQADGGLTSLRANPLKASAAQLCALLTEQGAAEVRQGIVPGSVLARFAGSPADN
                     ELFRQGYYHVEGQASQLAALCVCAAPGETVLDLCAAPGGKTILLAEQMQGTGELYSCDA
                     AENRVGLIRTAVDRMGFTGVHTLCNDATKPNPALPMADRILTDVPCSGLGILAKKPDLR
                     YKKLEADRQAELLATQAAILDTAAALLKAGGRLVYSTCTIDPAENQQQIAAFLQRHPEF
                     AVCAPEVPLPAGMTAGEHGCLSVPTRTGMDGFFLCVLQKAAATQ"
     CDS             complement(3692..4612)
                     /locus_tag="ctg8_29"
                     /transl_table=11
                     /translation="MRILFMGTPDIAAECLKALYAAGHDICAVYTRRDKPVGRKQVLTA
                     PPVKEVALAHGTPVFQPRTLRDGSEDENIRALAPELIVVVAYGCILPKSVLEMPHYGCI
                     NLHVSLLPKYRGSAPVQWSVLNGDAETGVSIMQMDEGLDTGDVLYCKKIVIDPEETSGE
                     LFDRVTAVGAEALCETIPQIAAGTLTAVPQQHENATLAPMLNKEMAEFHLTDTAVHIHN
                     WVRGMNPWPGAWFITSGGKKLKVMSSRVAAAHGEAPGTVLATKPLTVACGEGAIQLLEV
                     VPEGKKPMDGTAFAAGLRLKTGDSL"
     CDS             complement(4612..5148)
                     /locus_tag="ctg8_30"
                     /transl_table=11
                     /translation="MAIRNIVKEGDPILNKVCRPVTNFDDRLATLLDDMRETMIAADGV
                     GLAGPQVGMMRRLFVVWDTTDAPEEIPEDYEYKFIDFVNPEILAVSEEEETAYEGCLSF
                     PGHNGAVTRPVAVKVRAQDRNGEWFELEADGLLGRCIQHENDHLDGITIMESSEYFYED
                     TEEGKKAAREAKGNN"
     CDS             complement(5168..7429)
                     /locus_tag="ctg8_31"
                     /transl_table=11
                     /translation="MPKTVGIAVSNATFHFDKLYTYAVLPEHQNVVRLGSMVLVPFGKG
                     SRARMGVVLACDAEPEHSKLKYLFDVAPASACLTPELLRLVYFLKERTFCTYYEAVKAV
                     IPYGAQYKPAVAADGVTPVLQKQLTRHTENAYKLVGTLPQKPKPTAKQLAAVALLSGGS
                     RTLNELEDKGISRAVLDNLCTKGVLECSKVNKSIDLYASIPLRNDPITLTEQQQAAYDT
                     LLPKLEDTAPHSALLYGVTGSGKTLVFLKLISRCLELGRKALVLVPEISLTPQMILRLK
                     GQFGRRVAVQHSALNHTERLLQWQMIQDGGADIVVGTRSAVFSPLENIGLIIIDEEQEH
                     TYRSESAPRYSAHEVARQRAAENGALLLLASATPSTESFYAAQNGCTQLVRLTKRYGGN
                     PLPSVQIVDMRAELAAGNPREISLALEDAIRRNLEAEKQTILLLNRRGYQTIAQCEDCR
                     EVLKCPKCSVPMVYHKSAHKVLCHYCGSQQEPPPTLCPACGGKLQYRGFGTQKAEEELA
                     KLFPEARVLRMDQDSTAAKDAHEKLLAKFAAHEYDIMVGTQMVAKGLDFEDVTLVGVLG
                     IDSLLFAQGFRAYENVFSLITQVVGRSGRAKEPGFAIIQTTDPDNPVLTLAAAQDYDAF
                     YEQEIAYRKLGLYPPFCGLCIIGFAGAKENEVARAAARFSALLGQQAAKQPDLPLRILG
                     PTPGSIEKINDTYRYKLTVKCRNDRRFRDLVRSTLALYEKEKLPSRASVVVDLHSDGDI
                     "
     CDS             complement(7458..8030)
                     /locus_tag="ctg8_32"
                     /transl_table=11
                     /translation="MANDKFLFVVSGAAGTGKDSVVKALREAHPEIEKTVSATTRAPRP
                     GEQEGVDYYYRTREQFQQLLENDQVVEHNFYNGNYYGTLKSEVEKRLEAGKVVVLVIDV
                     HGAANIRRMFPGATTVFLLPPSVEELEHRLRGRGTETEESIQERLATARQELAEQDKFT
                     VKLVNNQIEPCAAELYQVICQRAGLQE"
     CDS             complement(8020..8298)
                     /locus_tag="ctg8_33"
                     /transl_table=11
                     /translation="MKLINIGFGNMVSAGRVVAVVSPDSAPVKRLVKEARERGMLIDAS
                     YGRSTRAVLIMDSDHVVLSALQPETVASRAAGQEGRASMEEEASHGE"
     CDS             complement(8317..9195)
                     /locus_tag="ctg8_34"
                     /transl_table=11
                     /translation="MILSMTGFGRGTAVLNGREITVELRSVNSRYFEYSSRIPRTCSSL
                     DSRLKKQLNQRISRGKVELSMTVQNVDAADTVVAVNMELARSYQQAMRDLSEQLGVKND
                     VSTAVLTRFPDVLTTRHADVDEEQLWQDVSAVTAQALDRFVEMRAAEGAKMKADVESRL
                     VFLEQCVGKVESLSAGRVENYTNRLYEKLKVILQDRDIDDARVLTEAAIFGDKTAVDEE
                     TVRLRSHIAQYRDILQLDEPVGRKLDFLTQELNRETNTIGSKCQDLDITRIVVDMKAEI
                     EKIREQIQNLE"
     CDS             complement(9464..9805)
                     /locus_tag="ctg8_35"
                     /transl_table=11
                     /translation="MRSIPEQRIAEFQEQDYQLYFGISKLEFDRMLKALHEAYRQEHKR
                     KTRFTKISMMDKLILTLIYRYEYRTMESIAKEYEVSLDTIADNIHWVERTLLNADILQT
                     SVTCVYKTN"
     CDS             complement(10001..10762)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_36"
                     /sec_met_domain="HMGL-like (E-value: 5.1e-10, bitscore:
                     30.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 6.8e-58, bitscore:
                     187.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSILKGIEAGADIIDTAMSPLSLGTSHMPTESLVAALQGTDYDTG
                     LDLKQLNVVRAYFAKLREKYIANGQISPKSLGVDANTLLYQVPGGMFSNMLKQLKDAGK
                     EDKLDEVLAEIPRVREDAGYPPLVTPTSQIVGTQAVFNVIMGERYKMVTKEFKGLVHGD
                     YGKTPAPIKPEFTKKILGDEQPITCRFADTLAPEMDKLKAEAAKWATQEEDVLTYAMFP
                     QVAPKFFDKRNAKKQGVDGDHVDYTNQSHPV"
     CDS             complement(10708..11421)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_37"
                     /sec_met_domain="HMGL-like (E-value: 3.3e-33, bitscore:
                     106.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKPIKVTEVVLRDAHQSLLATRMTMDEMRPILPEMDKINYFSV
                     ECWGGATFDSCIRFLDEDPWERLRILRKELPHQKLQMLFRGQNMLGYRPYADDAVEYFV
                     QKSVANGIDVIRIFDALNDPRNLQTAIKSANKEGAHVQGCISYTLSPVHNNEYFAAYAK
                     TLEEMGANSICIKDMAGLLTPYTCYDLVKKLKETVSIPVDIHSHYTAGLASMXXXXPCP
                     SSRASRQVPISSIPP"
     CDS             complement(11438..11815)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 76.7; E-value:
                     3.1e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_38"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.1e-24, bitscore:
                     76.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYYNITVNGVAYSVSVEETAAGAAPVAAAPAAPVAPKAAPAPAA
                     APKAAAGAAGAVAVKAPMPGNILDVKVAAGASVKAGDVLVILEAMKMENEIVAPQDGTV
                     ASINVNKGDTVNSGDVLVSMN"
     CDS             complement(11867..13186)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Propionyl_CoA3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_39"
                     /sec_met_domain="CT_Propionyl_CoA3 (E-value: 3e-66,
                     bitscore: 215.4, seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASKINKGEILAKFFDDGEYTALFADGAVSAACGYAAGQQAYAVY
                     QNGEAVTVKDVEKNIKVLEMAAQTGCPVVTFYNSVGAKLAEGLDVLTASAKLNAQIAKV
                     SGVVPQVAVVLGVCGGTSALSAANADVCIMAEGAELFFTAPFTSAAKGDKVADAGSAAA
                     AAKAGVASIVATDAAEAAEKAAHIVGLLPANNLTGPAIFEFEQPTAVLAAGAEPAKAAA
                     AVIDKDSAVELYAGFGKSVYTAFATIGGNAVGVVATGKQLCHNCVAKASRFVRLCDAFS
                     VPVVTIVDTEGFVPSVTDDVAGGIREAARLAATYADATTAKVAVLAGKAVGPVYTTLAA
                     ADLRIAVTGCTVSALEPSAAVSVLYKDEIDASDNIIAATKAKTAAYTAEVCSAASAVAA
                     GAADMSCDAANVRASVVAALELLSTKRAARLPKKHGNMAL"
     CDS             13449..15509
                     /locus_tag="ctg8_40"
                     /transl_table=11
                     /translation="MLHYIKKSYISGQSAKLYLYSAHEKPTKYAKEVEAILKRISVKFQ
                     QQEQIYRSLHAAARSLLSSKGRVFLLFLLFYKVLTNFLFVPALQLIWALTLRFAPIRYL
                     NNKTASRIFASPAIIGCIVVLAVLAAFWSLYEVAAMLQLLTRVRHGEPLRVGAVFRDAF
                     RSLVRVFLPQNLPLLLYGAALIPLTNFFLAANHLTQFAVPEYLWGLLKAHAANRFLFAL
                     AVLCVLALLLDGLVVLPKFLLEHKSFGCAFAESLRVLCSRAGQLFALALRWMLTATVRT
                     GPMLLCGALLFYCVILGVGFASTAALLALSRAALLIELPFLCLLMDCAMTAAQSTLTEA
                     LYEVTRQPDAILATISGELPALPREQTVLAGMMACAALVTCGVAAVYLLFPQTQPLQSV
                     LGLSDPVITYHRGYSSRAPENTMAAFETALEHGSPRIELDVQMTADGVAVVTHDTSLRR
                     CTGCNANIYDLPYAQVQQLDAGRWFHRQFTGSYIPTLEEVLALCKGKTELNIEIKPSTF
                     TPTLKAETVRLIHAYDYGADCVVTSQSYETLCKVKELDPDITTGYILALGVGTYYDLPA
                     ADFFSVESTFITAGMVQQIHLRGKTISAWTINRQQDAEKLLQLGVDDLITDKPEIIAPL
                     LARDKALDNRLLWLRDQIQELFAAPDAEETMEVEETIEDAIEDPEEVLDEA"
     CDS             complement(15642..15818)
                     /locus_tag="ctg8_41"
                     /transl_table=11
                     /translation="VDQEFVKDGDLTVAQYTAKVAKDLGGEIKIVKFARFVKGEGLEKR
                     ADDFASEVASMVK"
ORIGIN
        1 tctggttatc tgcccgggaa atgcgggcga taccgaagtc catcatgcgc agttggccgt
       61 tatccagcag cataatattc tggggcttga tatcccggtg cacgacgccg ttggcgtggg
      121 catgctccag cgccttgagg atctgggaga tgaagtgcac ggtctcccgg ctggaaagct
      181 tgccgccccg ctcgttgagg tactcccgca gggtcatgcc gtccacatat tccataacaa
      241 tatactgcag atggtcgttg accgagacat cgtacacctt aacgatattg gggtgattca
      301 gcagcgagat ggccttggat tcgtttttaa agcggcgcac aagatccggg tcgtgcatat
      361 actcccgccg cagcaccttg acggccacca cagtcccggc gggcacaggg ccgttctgtc
      421 cccgcatgac tgccttatac acgttggcca tgccgccgga gccgatcagc tcctgcacct
      481 cgtacagacc gtccagtctt ttaccgatca ggttatccat ggcgcacctc catcggctcc
      541 acccccacca gcagggcggt aatgttatcc gggccgccgt tttcgttggc agtacggatc
      601 agaacgtctg gcagatcgta aaaagacccg ctgcgcagca gttgctccag ctgctctgtg
      661 ggtacggcat tggtcaggcc gtccgtgcac agcaacagaa catcccctgc ctgcagcgct
      721 actgtggtga actccggctc cagccggtaa tccacgccca gcgcccgggt gatgatgttt
      781 ttctgcgggt gatgctctgc ctgctcctgc gtgatggtgc cgcagtccac cagctcctgc
      841 acataggagt ggtcgtgggt cagctgcgcc agcttaccgt cccggtacag gtaggcgcgg
      901 gaatcgcccg cgtggctcag ataggccttg ccgccgcgca ccagcgcgca gacagcagtg
      961 gtgcccatgc cggccagaga ctcctcccgc agtgccttct ggaacacata gcggttggca
     1021 ctgagcagcg cctttttcaa aaaagtctcc tcttcgccgg ggatgcactg gttgtactgc
     1081 tcctgaaagc agcgctcgat gacgctgcac gcacactgcg aggcttcccg cccgccgcgt
     1141 gcgccgccca tgccatcgca taccagcgcc catgctgcat cgccgggcag ttccccggca
     1201 cggtaatcat cctgattgtc ctgccggacg cgccccacgt ccgtttttcc tgcaagtttc
     1261 ataggtttct ccctctgttt atgccttgcc gttcatttcg tcgcggcgca actggccgca
     1321 ggcggcactg atctcactgc caaggcggcg gcgcaccgta gcgtttacgc caagactttc
     1381 aagcttttgc tggaaccggc gcacattggc cgcgtccgtg gcggaatacg gactgccgtc
     1441 caccggattg atggggatca gatttacatg agcacccatg ccccggatca ggtctgccag
     1501 ctgctttgcg cagacatcag aatcattgac accgcgcacc atggaatatt caaagctgac
     1561 ccggcggccg gtggtctcct gataccggcg cacggtctgg atcagttgct ccaccgggta
     1621 ggcatcgttg accggcatca tactgctgcg gatctggttg gtgggtgcgt gcagcgagat
     1681 ggaaagggtg agctgcagtt ttttctccgc cagctggtca atcttgggca caaggccgca
     1741 ggtggaaagg ctgatgttgc gcatgccgat attgacgccc tcgggcgagg tgatattctc
     1801 caaaaagcgc atcacttcgt caaagttgtc cagcggctcg ccgatgccca tgagcacgat
     1861 atgggagatg cgctcgccga tatctttctg ggcagtgtag atctcggagc agatctcgcc
     1921 tgcttcaagg ttgcgcacac gccccgcctg tgtggaggcg cagaaccggc agcccatgcg
     1981 gcagcccacc tgcgtggaca cgcacacggt attgccgtag tggtaacgca tgacaacggt
     2041 ctcgatgcag ttgccgtcag ccatgcgcag cagatacttc acagtaccgt ctttagcctc
     2101 ctgacggcgc tcgatctgcg gtgcagcgat ataaaaggtt tcttccagct ttgccagcag
     2161 ggtcttgggc tggtcggtca tggcagaaaa ctcggtgacc agcttctggt gcacccagtg
     2221 gaagatctgc tttgcccgga aacccggctg ccccagagct ttcagttcag cagtcaattc
     2281 tgccagcgtc aaagaagaaa tacagcgttt ttgttccatt ctgttctcct ataagaggat
     2341 acgacccaca aaggtcgtgc ttattgcgtt gcggcggctt tttgcagcac gcacaggaaa
     2401 aaaccgtcca tgccggtgcg ggtgggcacc gaaaggcaac catgctcccc tgccgtcatt
     2461 ccggcgggca gcggcacctc cggcgcgcag accgcaaatt ccgggtggcg ctgcaaaaag
     2521 gctgcgatct gctgctgatt ttctgccggg tcgatggtgc aggtggagta gaccagccgt
     2581 ccgcccgcct tgagcagcgc cgcagcggta tccagaattg ccgcctgtgt ggcaagcagt
     2641 tctgcctgcc ggtcagcttc cagcttttta tagcgcagat ccggcttttt tgccagaatg
     2701 cccaagccgc tgcaaggcac atccgtcagg atacggtctg ccatgggcag tgcggggttc
     2761 ggtttggtgg catcgttaca aagggtatgc accccggtaa agcccatgcg gtctaccgca
     2821 gtgcggatca gccccacacg gttctctgct gcatcgcagc tgtacagctc tcctgtgccc
     2881 tgcatctgct cggccagcag aatggtcttg ccgccggggg ctgcgcacag gtccagcacc
     2941 gtctcgccgg gggctgcgca cacgcaaagg gctgccagct ggctggcctg tccctccaca
     3001 tggtagtagc cctgtcggaa cagttcgttg tctgccggac tgccggcaaa tcgtgccagc
     3061 acgctgccgg gcacgatgcc ctgccgtacc tctgctgcgc cctgctctgt aagcagcgcg
     3121 cacagctgtg cagcgctggc cttgaggggg tttgcacgca gactggtcaa accgccatcg
     3181 gcctgatagg tcaggatgcc cagtgcttca tccgggtaat ttttgtggag gaattccgcc
     3241 acatcccgcc cggcagagcc taaaaccatc aggcgctgga tctcgtccgt aaaaacggca
     3301 gcgtccagat catagccgca ggccttgcgc agcacggcat tgacaaggcc ggaggcgctg
     3361 gattttttaa aggtgcgggt cagcttgact gcctcgttca ccgcagcaga gacaggaacc
     3421 tgcatatagc gagcctgtgc cagtgcagcg cgtaagattt cccgcacggg tgcatccagc
     3481 tttgccagac ccttgggcag aaactgctcc agaatatagt ccagcgtgcc gcgatgctcc
     3541 agcacggtgt agaaaatggc acttgcaaaa gccttatccc ggccttccag attctggcgc
     3601 ttgatttctg cgtccagcac cagattggaa aagccgtcct gctcctgccg taccagtgcg
     3661 gcaactgctg ccgcacgcgg atttgcggcc atcaaaggct atcccccgtt ttcaggcgca
     3721 gacccgctgc aaaggcagtg ccgtccatgg gctttttccc ctctggcacg acttccagca
     3781 gttggatggc accctcgccg caggctacgg tcaggggctt tgtggccagc accgtgccgg
     3841 gggcttcgcc atgagcggcg gccacgcggc tggacatcac cttgagcttt ttgccgccgg
     3901 aggtgatgaa ccatgcaccc ggccaagggt tcatgccgcg cacccagttg tggatatgga
     3961 cggcagtgtc ggtcaggtgg aactctgcca tctccttgtt cagcatgggg gcaagggtag
     4021 cgttctcgtg ctgttgcggc acagccgtca gggtgcctgc tgcgatctgg ggaatcgttt
     4081 cacacagagc ttcggcaccc acagcggtaa cgcggtcgaa cagttcaccg ctggtctcct
     4141 cggggtcgat gacgatcttt ttgcagtaca gcacatcacc ggtatccaga ccttcgtcca
     4201 tctgcatgat ggaaacgccg gtctcggcgt caccgttcag cacagaccac tgcaccggag
     4261 cgctgccgcg atatttcggc agcagcgaaa cgtgcaggtt gatgcagcca tagtggggca
     4321 tttccagcac ggacttcggc agaatgcagc cataggccac cactacgatc agttccgggg
     4381 caagggcgcg gatattttca tcctcgctgc cgtcccgcag ggtgcggggc tggaacacgg
     4441 gcgtgccgtg cgccagtgca acctccttga ccggcggtgc ggtgagcacc tgcttgcggc
     4501 cgaccggctt atcccgccgg gtgtacacgg cacagatatc atgcccggca gcatacaggg
     4561 ctttcaggca ctcggcagca atatccggcg tgcccatgaa caaaatgcgc atcagttatt
     4621 tcctttcgct tcgcgggcgg cctttttgcc ttcctcggta tcctcataga agtactcgct
     4681 ggactccatg atggtgatgc catccagatg gtcgttctcg tgctggatgc agcggcccag
     4741 caggccgtcg gcttccagct cgaaccattc gccgttgcgg tcctgcgcac gcaccttgac
     4801 ggcaaccggg cgggtcacag cgccgttgtg ccccgggaag gacaggcagc cctcgtaggc
     4861 cgtctcttcc tcctcagaaa cagcaaggat ctcggggttg acaaaatcaa tgaacttgta
     4921 ctcgtaatcc tcggggatct cctccggggc atcggtggtg tcccacacca cgaacaggcg
     4981 gcgcatcatg cccacctgcg gaccggccag acctacgccg tcggcggcga tcatagtctc
     5041 gcgcatatcg tccagcaggg tggccagacg gtcgtcaaaa ttggtcacag ggcggcagac
     5101 cttgttcagg atggggtcgc cttctttaac aatattacgg atagccataa tggtacctcc
     5161 agttttatca gatgtctccg tccgagtgca ggtctaccac gaccgatgca cgggacggca
     5221 gtttttcttt ttcatacagt gccagcgtgc tgcgcacaag gtcgcggaaa cggcggtcgt
     5281 tgcggcactt gacggtaagc ttatagcggt aggtgtcgtt gatcttttca atgctgccgg
     5341 gcgtaggacc cagaatgcgc aggggcagat ccggctgctt ggccgcctgc tgccctaaaa
     5401 gcgccgagaa acgggcagcg gcacgcgcca cctcgttctc ctttgcaccg gcaaagccga
     5461 tgatgcacag cccgcagaag ggcggataca agccaagctt gcggtaggcg atctcctgct
     5521 cgtagaaggc gtcgtaatcc tgcgcggcgg caagggtgag caccgggttg tccgggtcgg
     5581 tggtctggat gatggcaaag ccgggctctt ttgcgcggcc gctgcgtccc accacctgtg
     5641 taatcaggct gaacacgttc tcgtatgccc ggaaaccctg tgcgaacagc agcgaatcaa
     5701 tgcccagcac gcccacaagg gtcacatcct cgaaatccag acccttcgcc accatctggg
     5761 tgcctaccat gatatcgtat tcatgcgctg caaatttggc aagcagcttt tcgtgggcgt
     5821 ccttggcggc ggtagagtcc tgatccatgc gcagcacccg cgcctccggg aagagctttg
     5881 ccagttcctc ctcggccttc tgggtgccaa agccccggta ctgcagcttg ccgccgcagg
     5941 ccgggcaaag ggtgggcggc ggctcctgct gggagccgca atagtggcac agcaccttat
     6001 gcgctgattt gtggtatacc atgggtacgc tgcacttggg gcacttgagc acctcgcggc
     6061 agtcctcgca ctgggcaatg gtctggtagc cccggcggtt gagcagaaga atggtctgct
     6121 tttctgcctc aagattgcgg cggatggcat cctccagcgc aaggctgatc tcgcggggat
     6181 tgcctgctgc cagctctgcc cgcatatcca cgatctgcac gctgggcagc gggttgccgc
     6241 cgtagcgctt ggtcaggcgc accagttggg tgcatccgtt ctgtgcagcg tagaagctct
     6301 cggtgctggg ggtggcactg gccagaagca gcagtgcgcc gttttcggcg gcacgctgcc
     6361 gggcgacctc gtgggcagag tagcgtggtg cggattccga ccggtaggtg tgctcctgct
     6421 cctcgtcaat gatgataagg ccgatgtttt ccaacggcga aaacactgcg ctgcgggtgc
     6481 ctaccacgat atctgcgccg ccatcctgaa tcatctgcca ttgcaacaga cgctcggtgt
     6541 ggttgagcgc ggagtgctgc accgccacgc ggcggccgaa ctgtcctttg agccgcagga
     6601 tcatctgcgg ggtcaggctg atctccggca ccagcaccag cgccttgcgg ccaagttcca
     6661 gacagcggga aatcaacttt aaaaacacca gcgttttgcc gctgccggtc acgccgtaca
     6721 acagtgccga atggggtgcg gtatcttcta gcttaggcag cagcgtgtcg taagcggcct
     6781 gctgctgctc tgtgagggtg atggggtcgt tacgcagcgg gatggaggcg tacaggtcga
     6841 tggacttatt caccttgctg cattccagca cacccttggt gcacaggtta tccagcaccg
     6901 cgcggctgat gcctttatcc tccagttcgt tcagggtgcg agagccgccg ctcagcagcg
     6961 ccaccgccgc cagctgcttt gccgtaggct ttggcttttg cggcagagtg cccacaagct
     7021 tataggcatt ttcggtgtga cgggtaagct gcttttgcag caccggggtc acaccgtctg
     7081 ccgccacggc gggcttgtac tgcgcaccgt acggaatgac tgccttgacg gcctcgtagt
     7141 aggtacagaa ggtgcgttcc tttaaaaaat acaccagccg cagcagctcc ggggtcaagc
     7201 aggccgaagc cggggctacg tcaaacagat atttcagctt ggagtgctcc ggctcggcat
     7261 cgcaggccag taccacaccc atgcgggcgc ggctaccctt gccgaagggt accagtacca
     7321 tgctgcccag acgcaccaca ttctggtgct ccggcagaac ggcgtaggta tacagcttat
     7381 caaaatggaa ggtcgcattg ctgacggcaa tgcctaccgt tttgggcatt cgtccaactc
     7441 cttcaacgct tgatttttca ctcctgcaac ccggcgcgct gacagatgac ctgatacagc
     7501 tctgcggcgc agggctcgat ttgattattg accagcttta cggtaaactt atcctgctcg
     7561 gccagttcct gccgggcggt ggcgagacgc tcctgaatgc tttcctcggt ctcggtgccg
     7621 cggccgcgca gacggtgctc cagttcctcc acagagggcg gcagcaggaa cacggtggta
     7681 gcgcccggga acatccggcg gatattggca gcgccgtgca catcgatgac cagcacgact
     7741 accttaccgg cctccagccg cttttccacc tcagacttca gggtgccgta gtagttgccg
     7801 ttatagaagt tgtgctccac cacctgatcg ttttccagca gctgctggaa ctgctcgcgg
     7861 gtgcggtagt agtagtccac accctcctgc tcgccggggc gcggggcgcg tgtggtggca
     7921 gagacagtct tttcgatttc ggggtgtgcc tcgcgcagtg ccttgaccac gctgtccttg
     7981 ccggtgccgg ctgcgccgga aactacaaac agaaatttat cattcgccat gagatgcttc
     8041 ttcctccatt gatgctctac cctcctgccc ggcggcgcgg cttgccaccg tttcgggctg
     8101 aagggcggac agcacgacat gatcggagtc catgatgagc acagctcggg tgctgcggcc
     8161 gtaagaggca tcgatcagca tcccgcgctc gcgtgcttcc ttcaccagac gtttgaccgg
     8221 tgcggagtcc gggctgacga ctgccaccac acgccccgca ctgaccatat tgccaaagcc
     8281 gatgttgatg agtttcatag gctcctccac aacatattat tccagattct ggatctgctc
     8341 gcggattttt tcgatctccg ccttcatatc caccacaata cgggtgatat ccagatcctg
     8401 acacttggag ccgatggtat tggtctcacg gttcaactcc tgcgtcagga aatccagctt
     8461 acggcccacg ggctcgtcca gctgcaggat atcgcggtac tgggcaatgt ggctgcgcag
     8521 acggacagtt tcttcatcca cggcagtctt atcgccaaag atggcggcct cggtcagcac
     8581 acgggcatca tcaatgtcac gatcctgcag gatgaccttg agcttttcgt acaggcggtt
     8641 ggtgtagttc tctacccggc ctgcactcag gctctccacc ttgccgacgc actgttccag
     8701 aaacacaaga cggctttcca cgtctgcctt catcttggcg ccctcggcgg cacgcatctc
     8761 cacaaagcga tccagcgcct gcgcggtaac ggcagacaca tcctgccaca gctgctcctc
     8821 gtccacatcg gcgtggcggg tggtcagcac atccgggaag cgggtcagaa cggcggtgga
     8881 cacatcattt ttgaccccca gctgctcgga caggtcccgc atggcctgct gatagctgcg
     8941 ggcaagctcc atgttgacgg cgaccacggt atccgctgcg tccacgttct ggacggtcat
     9001 gctaagctct accttgccgc gggagatccg ctggttgagc tgctttttca ggcggctgtc
     9061 cagagaactg caggtgcgcg ggatgcggga ggaatactcg aaatagcggg agttcacgct
     9121 gcgcagttcc acagtgatct cacggccatt gagcacggca gttcccctgc cgaaaccggt
     9181 catgcttaag atcatactag ctcctattct tttgcggttt aacttcggtt tttctgtata
     9241 ggtatccgct ttgggcacac aagcccatgt tacgatacat atagcatcat tttactattc
     9301 ttttctgaaa aattcaaggt gcagactgca tccgtgcaaa aaacacagtt ttcattttta
     9361 ctgctgcgca gccaaaacaa catggctgcg gcagttaccg cttttccaga agttttcccc
     9421 ttgtaaaaaa tataaccccg cgttttcacg cagggtcata acatcagttc gtcttataaa
     9481 cgcaggtcac actggtttgc aggatatctg cattgagcag cgtgcgctcc acccaatgga
     9541 tgttgtcggc aatggtatcc agagaaacct cgtattcctt ggcaatgctt tccatcgtgc
     9601 ggtactcgta gcgatagatc agggtcagga tgagtttatc catcatagag atcttggtaa
     9661 agcgggtctt gcgcttatgc tcctgacggt aagcctcatg cagagccttg agcatccggt
     9721 caaattccag ctttgaaatg ccaaaataca gttgatagtc ctgctcctga aactcagcaa
     9781 tgcgctgctc cgggatgctt cgcatagcat tttcctccac atcatttgtt gtattgtacg
     9841 gctataccaa acattataaa aggtattggg cggcaagtca atgtgtatgc agaagttttt
     9901 ccgggattgg ccgacagagt acgtcttgtg cctttgccgg atacgcaaaa aaggctgctg
     9961 cacagcattt tgtgcagcag ccctgaaagg gacttattta tcagacagga tgggactggt
    10021 tggtgtagtc cacatgatcg ccgtccacgc cctgcttttt ggcattgcgc ttatcgaaga
    10081 acttgggagc gacctgcggg aacatagcgt aggtcagcac gtcctcttcc tgcgttgccc
    10141 acttggcagc ctcggccttc agcttgtcca tctcgggagc cagcgtatcg gcaaagcggc
    10201 aggtaatggg ctgctcgtcg ccaaggatct tcttggtgaa ctcgggcttg atgggagcgg
    10261 gagttttgcc gtagtcgccg tggaccagac ccttgaactc cttggtgacc atcttgtagc
    10321 gctcgcccat gatgacgttg aacaccgcct gcgtaccaac gatctggctg gtgggggtga
    10381 ccagcggcgg ataacctgca tcctcacgga cgcggggaat ctcggccagc acttcgtcca
    10441 gcttgtcttc cttgccggca tccttcagct gcttgagcat gttggagaac atgccgcccg
    10501 gcacctgata cagcagggtg ttggcgtcca cacccaagct cttggggctg atctggccgt
    10561 tggcgatgta cttctcacgc agctttgcaa agtaagcgcg cacgacattc agctgcttca
    10621 gatccagacc ggtatcgtag tcggtgccct gcagggcagc caccaagctc tcggtgggca
    10681 tgtggctggt gccgaggctc agggggctca tggcggtatc gatgatatcg gcacctgcct
    10741 cgatgccctt gaggatggac atggannnnn nnnnnacatg gaagccagac ctgcggtgta
    10801 gtggctgtgg atgtccacag ggatgctgac agtctccttc agcttcttga ccagatcata
    10861 gcaggtatag ggagtgagca gacctgccat atccttgatg cagatggagt ttgcgcccat
    10921 ctcctccaaa gtcttggcgt aggctgcaaa gtactcgttg ttgtgcacag ggctcagggt
    10981 gtagctgatg cagccctgca catgagcgcc ctctttgttg gcagacttga tggcagtctg
    11041 caggttgcgg gggtcgttca gagcatcgaa gatgcggatg acgtcgatgc cgttggcaac
    11101 agacttctgt acaaagtact ccacagcgtc atctgcgtag ggacggtagc ccagcatatt
    11161 ctggccgcgg aacagcatct gcagcttctg gtgcggcagt tccttgcgca ggatgcgcag
    11221 acgctcccaa ggatcctcgt ccaggaagcg gatgcagctg tcgaacgtag cgccgcccca
    11281 gcactccacg gagaagtagt tgatcttgtc catttcgggc aggatggggc gcatctcgtc
    11341 catggtcata cgggtagcca gcaaagactg gtgcgcatca cgcaggacga cctcggtcac
    11401 cttgatcggc ttttttgcca tggttgtcac ctcttcctta gttcatggaa accagaacgt
    11461 caccggagtt gacggtatcg cccttgttca cgttgatgga agccacggtg ccatcctgcg
    11521 gagcaacgat ctcgttctcc atcttcatgg cctcgaggat gaccagcacg tcgccggcct
    11581 tgacagaagc accggcagcg accttgacat ccagaatgtt gccgggcatg ggagccttga
    11641 cggcaacagc accggctgca ccggcggctg ccttaggagc agctgcagga gcgggagcgg
    11701 ccttgggtgc gacgggtgct gcgggagcag cggcaacagg agcagcgcct gcggcagttt
    11761 cctcaacgga aacgctgtaa gcaacaccat tgacagtaat attgtagtac ttcatggaag
    11821 gatcctccaa ttcaaaatcg aactcaatta acttacattc ggacgcttac agggccatat
    11881 tgccatgctt cttgggcagg cgggcagcgc gcttggtgct cagcagctcc agtgcagcca
    11941 caacgctggc acgcacatta gcggcatcac agctcatatc ggcagcaccg gcggccactg
    12001 cgctggcagc gctgcacacc tcagcggtgt aggcagcagt cttagccttg gtggcggcaa
    12061 tgatgttgtc ggaagcatcg atctcgtcct tgtacagcac gctgacagcg gcgctgggct
    12121 ccagtgcgct gacggtgcag ccggtcacag cgatgcgcag atcggcagca gccagagtgg
    12181 tgtacacagg gcccacagcc ttgccggcca gcactgccac ttttgcggtg gtagcatcgg
    12241 cgtaggtagc ggccagacgg gcagcctcgc ggatgccgcc agccacgtca tcggtaacgc
    12301 tgggcacaaa gccctcggta tccacgatgg tgaccacagg cacgctgaag gcatcgcaca
    12361 ggcgcacaaa gcgggaagct ttggctacgc agttgtgaca cagctgctta ccggttgcca
    12421 caacgcccac ggcgttgccg ccgatggttg caaatgcggt gtaaacagac ttaccaaagc
    12481 ctgcgtacag ctccacagcg ctgtccttat cgatcacagc ggcagcagcc tttgcgggct
    12541 cggcaccggc agccagaaca gcggtgggct gctcgaactc gaaaattgcc ggaccggtca
    12601 ggttgttggc gggcagcaga cccacgatgt gagcagcctt ttcagcagcc tctgcggcat
    12661 cggtagccac gatggaagct acgcctgcct tggcggcagc agcggcgctg cctgcgtcgg
    12721 cgaccttatc gcccttggct gcggaggtga acggagcggt gaagaacagc tctgcgccct
    12781 cggccatgat gcagacgtct gcgttggcag cgctcagagc gctggtgccg ccgcagacac
    12841 ccagaacaac ggccacctgc ggaacaacac cggagacctt tgcgatctgt gcattcagct
    12901 ttgcgctggc ggtcagcacg tccagaccct cggccagctt tgcgccaacc gagttataga
    12961 aggtgaccac cgggcagccg gtctgtgcag ccatttccag aaccttgatg ttcttttcaa
    13021 catcctttac ggtgacagcc tcgccgttct gataaacggc gtaagcctgc tgacctgcag
    13081 catagccgca ggcagcgctc actgcaccat cagcaaacag tgcagtgtac tccccgtcat
    13141 cgaagaactt ggcgaggatt tctcccttat tgatctttga agccataatt agacctcctg
    13201 gttgtctgtg tgagctttca aaattatatt tattatacag aagctggcaa aaaaatgcaa
    13261 gggattctat aaaattccat gcgattcaac atccgtcact tatagatact caaattttta
    13321 acgattcatc gttttgcacg ttttatctgg acaaatgcta tcacacgccc attttgtgga
    13381 tgtagaaatt ttcccggttt ttttggcaaa actgcacccg tctgctgcgt tttctttccg
    13441 ttgtgtttat gttacactat attaaaaaat catatatttc cgggcaatct gccaaactgt
    13501 acctatacag cgcacacgaa aagcccacca aatatgcaaa agaggttgaa gctatcttga
    13561 agcgaatttc cgtaaagttc cagcagcagg agcagatcta ccgctctctg cacgctgccg
    13621 ctcgttccct gctttcgtca aaggggcggg tgtttctgct ttttctgttg ttttataagg
    13681 tgctgacaaa cttcttgttc gtaccggcgc tgcagctgat ctgggcgctg acactgcggt
    13741 ttgcgcccat ccgctacctc aacaacaaga ccgcttcccg catctttgct tcccctgcca
    13801 tcatcgggtg catcgtcgtg cttgcggtgc tggcagcctt ttggagcctg tatgaggttg
    13861 ccgcgatgct gcagctattg acgcgggtgc ggcacggtga gccgctgcgg gtgggtgcgg
    13921 tgttccggga tgcctttcgc agccttgtgc gagtgtttct gccgcagaat cttccactgc
    13981 tgctgtatgg tgctgccctg atcccgctga cgaacttttt tcttgccgcg aatcatctga
    14041 cccagtttgc cgtgccggaa tatctctggg ggctgctgaa agcgcacgct gccaatcgtt
    14101 ttctatttgc tctggcagtg ctttgtgtgc tggcgctgct gctggacgga cttgtagtgc
    14161 tgccaaaatt tctgctggaa cataaaagct ttggctgtgc atttgcggag agtctgcggg
    14221 ttttgtgcag ccgcgccggg cagctgtttg cgctggcact gcgctggatg ctgaccgcta
    14281 ctgtgcgcac cgggccgatg ctgctgtgcg gggctttgct gttctattgt gtcattcttg
    14341 gtgtcggctt tgccagcact gctgccctgc tggcgctttc tcgcgcggca ctgctgatcg
    14401 aactgccgtt cctttgtctg ctcatggact gcgccatgac ggcggcgcaa agcaccctta
    14461 cagaggcact gtatgaagtg acccgccagc ccgatgcaat actggcgacc atttccggag
    14521 agctccccgc cctgccccgt gagcagacgg tgttggccgg gatgatggcc tgcgccgcac
    14581 tggtcacctg cggcgtagca gcggtatatc tgcttttccc gcaaacacag ccgctgcaaa
    14641 gcgtgctggg tctttctgac ccggtgatca cctaccaccg gggctattct tcccgtgcgc
    14701 cggagaacac catggctgcc ttcgagaccg cgctggagca cggcagtccc cgcattgagc
    14761 tggacgtgca gatgactgct gacggcgtag ccgtagtgac ccacgatacc agcctgcgcc
    14821 ggtgtaccgg ctgcaacgcc aacatctatg acctgcccta tgcacaggtg cagcagctgg
    14881 atgccgggcg ctggttccat cggcagttta cgggctccta tattcctacg ctggaagagg
    14941 ttctggcgct gtgcaagggc aagactgagc tgaacatcga gatcaagccc agcaccttta
    15001 cgccgacatt gaaggccgaa acggtgcggc tgatccacgc atacgactac ggcgcggact
    15061 gcgtggtcac ctctcaaagc tacgagaccc tgtgcaaggt gaaggagctg gacccggaca
    15121 ttaccacagg gtatattctg gcgctgggcg tgggtaccta ctacgacctg cctgccgcag
    15181 actttttcag tgtagaatcc acctttatca ccgccggtat ggtgcagcag atccatctgc
    15241 gcggcaagac catctctgca tggaccatca accgccagca ggatgcggaa aagctgttgc
    15301 agttgggtgt ggatgacctg atcaccgaca agcccgagat cattgcgccg ctgctggcac
    15361 gggataaggc tttggacaac cgcctgctct ggctgcggga tcaaatccaa gagctgtttg
    15421 ccgcccccga tgctgaagaa acgatggagg tcgaggagac catcgaggac gctattgagg
    15481 atcccgaaga ggttttggac gaagcataag cggaagattt ttacagcaat accgggcagg
    15541 ctgcgggctg cccggtattt gcattttcat aaacataaaa aaggagccgc agcaccctgt
    15601 tacaggtact gcggctcccc ttttgtcttt ggaagtttaa attacttcac catgcttgca
    15661 acttcagatg cgaagtcgtc agcacgcttc tccagaccct cgcccttgac aaagcgggcg
    15721 aacttgacga tcttgatctc gccgcccagg tccttagcga ccttagcggt gtactgagca
    15781 acggtcaggt cgccgtcctt gacgaactcc tgatcgac
//
