LOCUS       gnlProkkaAGOJHKEG_76   15221 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AGOJHKEG_76.
ACCESSION   gnlProkkaAGOJHKEG_76
VERSION     gnlProkkaAGOJHKEG_76
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 22:04:09
            Original ID  :: gnl|Prokka|AGOJHKEG_76
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15221
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15221
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4483:6255]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4484..6255
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..15221
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15221
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             141..887
                     /locus_tag="ctg76_1"
                     /transl_table=11
                     /translation="MYQFFIQPDSIKEEEIWIADPQDVNHIRNVLRMKKGEKVSLCCEA
                     KGKEYICGIEEIESDIVKAAIIDINGESRELPVKITLFQGLPKSDKMELIIQKAVELGA
                     AEIVPMATKRAVVKLDAKKAAKKVQRWNEIAKSAAKQSKRGLIPEVKPVMSFKEAVEYG
                     KSMDMLLIPYEDAKGIAHSREVVETVKDKKSLGIYIGPEGGFPEEEVSFAMKAGAEPVT
                     LGHRILRTETAGMTLLSILMFMLEED"
     CDS             974..2083
                     /locus_tag="ctg76_2"
                     /transl_table=11
                     /translation="MAGSSFGTLFCMTTWGETHGKGVGVVVDGCPAGLSLCEEDIQKYL
                     NRRKPGQSKYTTKRKEDDKVEILSGVFEGKTTGTPISMAVFNKDQHSKDYSAIKDIYRP
                     GHADYTFDKKYGFRDYRGGGRSSGRETTARVAAGAVAAKVLKELGIEVFAYTKAIGPVQ
                     IDENRFSKEERDKNALYMPDAQAAAQAEEYLQEKMKELDSCGGIVECVITGMPVGVGEP
                     VFDKLSANLGKAILSIGAVKGFEIGDGFAAAASAGSENNDDFYNDNGTVKKKTNHAGGV
                     LGGMSDGSVITFRAAFKPTPSIAQPQQTVNRDGKDTEIVIHGRHDPIIVPRAVVVVETM
                     AAVTVLDLLLQNMGSRLDSVKNFYENEKK"
     CDS             2152..3294
                     /locus_tag="ctg76_3"
                     /transl_table=11
                     /translation="MYKLLTKDGMAKRGEFETVHGTIQTPVFMNVGTVGAIKGAVSTDD
                     LRTIGTQVELSNTYHLHVRTGDKLIKQFGGLHKFMGWDKPILTDSGGFQVFSLSGLRKI
                     KEEGVYFQSHIDGHHIFMGPEESMQIQSNLGSTIAMAFDECPSSRADRTYIQNSVDRTT
                     RWLERCKKKMQELNSLPDTVNPHQMLFGINQGGVFADIRIEHAKRISELDLDGYAVGGL
                     AVGETHDEMYYILDEVVPYLPENKPTYLMGVGTPSNIIEAVDRGIDFFDCVYPSRNGRH
                     GHVYTHHGKLNLFNKKFELDPRPIEEGCQCPSCRTYSRAYIRHLLKAKEMLGMRLCVLH
                     NLYFYNHLMEEIRGAIDEHRYKEFKKTTLEGFLTPEEEYR"
     CDS             3328..3648
                     /locus_tag="ctg76_4"
                     /transl_table=11
                     /translation="MLLAQSASASSSITMIIAYVILFGAIIYFMTIRPQKKQQKAADEM
                     HAGMQAGDSVLTTSGFYGVIIDIMDDTVIVEFGNNRNCRIPMQKDAIAAVEKPNLTKTE
                     EE"
     CDS             4004..4384
                     /locus_tag="ctg76_5"
                     /transl_table=11
                     /translation="MDGISYKKWMERAAGLFLSALIAVLLTMLFLAVFAFAMLKGNLSA
                     SVEKIGLIVMSVMACFVGGFLCGKKNMKKRYLWGLGVGVLYCLFFGVIRVGMGQAFVTD
                     TTAFFTMMLYCAAGGMLGGMLS"
     CDS             4484..4630
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg76_6"
                     /sec_met_domain="TIGR03973 (E-value: 5.4e-23, bitscore:
                     70.6, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 2.7e-22, bitscore: 68.4,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVKTLTGNKTYGTTMCKGGCGECQTSCQSACKTSCTVGNQTCE
                     SNK"
     CDS             4891..6255
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg76_7"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.6e-33,
                     bitscore: 104.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.5e-16, bitscore: 49.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3e-14, bitscore: 43.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.6e-20, bitscore:
                     63.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYKNNGYNIVMDVCSGAIHVVDDVTYDVIALYEEKSLEEIEN
                     ELSYSKEDIEEAYKEVTSLKEEGLLFTEDIYEDYIKEVKSRKTVVKALCLHIAHDCNLA
                     CRYCFAEEGEYKGHRELMSAKVGKAALDFLVANSGNRHNLEVDFFGGEPTMNFGVVKEV
                     VEYGRSLEEKHNKHFRFTLTTNGVLLNDEIMEFANKEMDNVVLSVDGRKEIHDYMRPTR
                     NGKPSYDLIMPKFIRFAESRHQQKYYVRGTFTNRNLDFSKDVLHLADLGFEQISMEPVV
                     GQPEEPYAIQEKDLPQIFDEYDRLAKEMIKREKAGKGFNFFHFMIDLTGGPCVAKRLSG
                     CGSGTEYLAVTPWGDLYPCHQFVGEEKFLLGNVFDGIKRTDICDEFRSCNVYTKKKCKD
                     CFARFYCSGGCPANSYNFHGTIDDSYDLSCDMERKRVECAIMIKAALADTEGEEE"
     CDS             6256..8031
                     /locus_tag="ctg76_8"
                     /transl_table=11
                     /translation="MEKWFIASKRADFNKIGEIFHISPVTARLMRNRSLTTVREMQRYL
                     YGSLSDLYDSHLLKDADKGAEIIKEKIETGKKIRIISDYDVDGVSSNYILYQGLKRCGA
                     DVDYKIPDRVEDGYGINEHLIEKAAGDGIDTIITCDNGIAAAEQIAYGNSLGLTLIVTD
                     HHDIPFQRQEDGSISYNLPSAAAVINPKQKDCPYPFENICGAVVVYKFIQVLYDLFGID
                     RRESEAFLEIAAMATVCDVMPLCDENRIIVKEGLQRIQHTNITGLQALIEANHLEEKKI
                     SSYHFGFILGPCINASGRLTSAKDALELLLCEDKELCRQKAEALTQLNAERKEMTANGV
                     KAAKEYLESTGHGNDKVLVVYLPNCHESIAGIIAGRMKEHYHKPVFVITRTKEGLKGSG
                     RSIEAYHMYKEMNKIKECFDKFGGHPMAAGFSMQEDRLEEFREKLNANATLTEDDFAEK
                     VHIDVALPISYLSESLINEFELLEPFGNENTKPLFAQKDLYIKGMRVLGTTGRCLKLFL
                     SDANGTSIDAMYFGESDGFLEELISFCGKEEAQRIQKGLSHHIWMDVTYYPQVNEWRGQ
                     KNIQIVIQNYRFKNL"
     CDS             8201..9046
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179:hydrolase (Score: 177.4; E-value: 6.7e-54)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg76_9"
                     /transl_table=11
                     /translation="MEQEKKQPDVRLIGLDLDGTTLTSDKVLTPHTKEVLEKCLAEGIQ
                     VLPATGRVKSGIPEYLTQIEGMRYVILSNGASVLDLKEDKVLYQNCIPWERALELFDVL
                     ETYDTFYDIYALGAGWCEARFYDNVENYGIEKHIEKLVRTSRNRIDDLREWMKENKAPV
                     EKINMFFAKEEDRQRAFRELGKIEDLAVTCSLGNNLEINGATCNKGDAMLNLGKILDIP
                     IESIMACGDGNNDFEMVKMAGVGVAMKNGEESLKEVADFVTKTNDEEGVAYAIEHFCNV
                     "
     CDS             9149..9706
                     /locus_tag="ctg76_10"
                     /transl_table=11
                     /translation="MPDLGAERVDKVKKLEDYVINIPDFPKPGIIFRDITSILRDPEGL
                     KLSVHELMHCLEGTEFDVVVGAESRGFLFGMPLAYNKSKGFVPVRKKGKLPRETVSKEY
                     ALEYGTAEIEIHKEDIRPGQRIVFVDDLLATGGTAKAAIDLIEELGGVVVKVLFVMELE
                     GLHGRDVLKGYDVESVITYPGK"
     CDS             9904..10773
                     /locus_tag="ctg76_11"
                     /transl_table=11
                     /translation="MEHLNLLQRIEKKSSEFSKGQRRLAQYITENYDIAAYLTASKLGK
                     EAGVSESTVVRFAYQLDYEGYPELQKAIQVIVKTNSNSIQRMSLSSKRYQEKGVLKSIL
                     YTDAERLRDTIQSGVDEEEFNRSVMLINDARRLYILGARSAAYLAGLMGYYFKMMFDNV
                     IIVDANSTSETLEQIYDISDKDVMMGITFPRYSKRTICALQYAKNHGAKTIALTDNMQS
                     PIVEYADCKLIAKSDVMTIVDSLVCPLSVVNAMVTAIALLRKDDVEKRLMALEELWNEY
                     DVYNRSLL"
     CDS             10773..12014
                     /locus_tag="ctg76_12"
                     /transl_table=11
                     /translation="MNKVIIVGGGAAGMMAAISASKEGKKVCILEKNEKLGKKLFITGK
                     GRCNITNACPADEFLTHVVTNPRFLYSTFSQFNNEDMMDYLEEIGLPIKTERGQRVFPQ
                     SDRSSDVIDALKKQCKKGGVQIYYHTEVKELLFDEEKENCVGVLLSDGKKMMGDSVILA
                     CGGFSYASTGSNGSGYTLAKQAGHKIKSIEPSLVPFEMKEMWCKDLMGLTLKNIGVRIK
                     AKKKTVYEGFGEFLFTHFGVSGPLVLTASTCLGKYQKELEAGELKLILDLKASLTPEQL
                     DKRFLREFDTYRNKNISNVMERLLPKKMIPVFLEEAQIPEDKKIRDISKKERRHMIELM
                     KNFEMHITGVRGFNEAIVTRGGVNVKEINPSTMESKKVKHLFFAGEMMDLDAVTGGYNL
                     QIAWTTGYVAGKNA"
     CDS             12150..12815
                     /locus_tag="ctg76_13"
                     /transl_table=11
                     /translation="MYSIAIDGPAGAGKSTIAKAIAEDIGFIYVDTGAMYRAIALYFLR
                     KGIDGHDRKLVAAECPNIHVTLEYDEEGKQQVILNGENVTGYIRKEEVGKMASVTSAVP
                     EVRAALLDLQRDMAKTSDILMDGRDIGTNVLPDASLKIYLTASADVRAKRRYDELKEKG
                     ADCDIEQIKTDIIARDKQDMEREIAPLCQAEDAILVDSSDMSIPQVIDTIISEFKKIK"
     CDS             12833..14716
                     /locus_tag="ctg76_14"
                     /transl_table=11
                     /translation="MKINIAKSAGFCFGVKRAVDTVYKESSKKNVYTFGPIIHNDEVVA
                     DLERQGVHVINDSEDFKSLSEGTIIIRSHGVSKAIYDEILNAGLDLVDATCPFVRKIHK
                     IVERESGDGRVIIIIGNNHHPEVEGIMGWCHTHPIVIENREQAEGIELDADTKISIVSQ
                     TTFNYNKFQDLVEIISEKGYDINVFNTICNATEERQTEVRELAKKSDAMIVIGGRHSSN
                     TQKLFEISKKECSNTFYIQTKNDLNMEDFSNIGMLGITAGASTPNNIIKEVHESMAEMS
                     FDQMLEESFKTIRNGEVVQGTIIDVKEDEIILNIGYKADGIISRNEYSNDQNLDLTTVA
                     KVGDEMEAKVLKVNDGEGQVLLTYKRLKAEKGNKRLEEAFNNHEVLKAPVAKVLDGGLS
                     VVVEETRVFIPASLVSDTYEKNLKKYDGQEIEFVITEFNPRKRRIIGDRKQLLVAEKKA
                     KQEALFAKIEAGMTVEGTVKNVTDFGAFIDLGGADGLLHISEMSWGRVENPKKVFTVGE
                     KLNVLIKDIQGEKIALSLKFPETNPWLHADEKYAVGNEVTGKVARMTDFGAFVELEPGV
                     DALLHVSQIAKEHIEKPSDVLKVGQEVTAKVVDFKKDDRKISLSIKALDNE"
ORIGIN
        1 tcacaaatat gccttattgg gggcaatggc ttcgtctgta gttcgcttaa tgaattaaat
       61 agtaaattga catatttttt gaaagcggtt atgatatatt atgtctgcct tatagggcaa
      121 agaatgaagt ggaggagttt atgtatcagt tttttataca gcctgatagt attaaagaag
      181 aggagatttg gattgcagac ccgcaggatg taaatcacat tcgtaatgtt ctccgtatga
      241 aaaagggaga aaaagtttct ctttgttgcg aagcaaaggg aaaggagtac atttgtggta
      301 tagaagagat agaatcagat atcgtcaagg cggcaattat tgatattaac ggagagtcga
      361 gagaactgcc ggtaaagatt acgctttttc agggacttcc aaagagtgac aagatggaac
      421 ttatcattca aaaagcggta gaactcgggg cggcagagat tgtgccgatg gcaacaaaaa
      481 gagcggttgt aaagcttgat gcgaagaagg cagcaaagaa agtacagcga tggaatgaga
      541 ttgcaaaaag tgcggctaag cagtcaaaga gaggtctgat tccagaagta aagcccgtaa
      601 tgtcttttaa agaagctgtg gaatatggaa agagtatgga tatgctactc attccgtatg
      661 aggatgccaa gggaatcgca cattccagag aagtggtaga aacagtaaag gataaaaaga
      721 gtctgggaat ttatatcgga ccggaaggtg gttttccgga agaagaggtt tcttttgcga
      781 tgaaagcagg agcagaaccg gttacacttg ggcaccgcat tttgcggacg gaaacggcgg
      841 gaatgacatt actttctata ttaatgttta tgttagaaga agattgattt ggtgtagata
      901 gtagaaattt aattgataaa aagtcaaaca gaggatactc tgtttgacga tagaatttta
      961 acaggaggac aaaatggcag gttcatcatt tgggacattg ttttgtatga caacatgggg
     1021 agaaacacac ggaaaaggtg tgggtgttgt agtggacggt tgtccggcag gcctttctct
     1081 ttgtgaggag gatatacaga agtatttgaa tagaagaaag ccgggacagt caaagtacac
     1141 aacaaagcga aaagaagatg ataaggtgga gattttatcg ggagtttttg agggaaagac
     1201 aacaggaact ccaatttcta tggcggtatt taataaagac cagcattcaa aagattactc
     1261 tgcaatcaag gatatttacc gtccgggcca tgcagattat acatttgata agaagtatgg
     1321 tttccgtgat tatcgcggtg gcggccgttc ttcaggaaga gagacaacag caagagtagc
     1381 agcaggtgca gtagcagcaa aagtattaaa agaacttggc attgaagtat ttgcttatac
     1441 aaaagcaatt gggccagttc aaattgatga aaatagattt tcaaaagaag aacgagataa
     1501 gaacgcatta tatatgccgg atgcacaggc agcagcacag gcggaagagt atcttcagga
     1561 gaaaatgaaa gagttagatt cctgtggtgg cattgtggaa tgtgtaatta caggaatgcc
     1621 cgtcggtgtt ggtgagccgg tatttgataa attaagtgcg aatcttggaa aagcaatttt
     1681 atctatcgga gcagtaaaag gcttcgaaat cggagatgga tttgcggcgg cagcaagtgc
     1741 tggttctgag aataatgatg atttttataa tgataatggt acggtgaaaa agaaaacgaa
     1801 tcatgcaggt ggtgtgcttg gtggaatgag cgatggttca gtaattacat ttcgtgcagc
     1861 atttaagcca actccatcga ttgcacagcc acagcagaca gtaaatagag atggcaaaga
     1921 tacagaaatt gtaattcacg gaagacatga cccgattatt gtgccaagag cagtcgttgt
     1981 tgtagagaca atggcagcgg taactgttct tgatctgctg cttcagaata tggggagccg
     2041 cttagatagc gtaaaaaact tctacgaaaa tgagaaaaaa taaggataga ggttgtacat
     2101 ttgctttgtt tatgataaaa tcaaatttat gtgtaaagtt aaggagagta tatgtataag
     2161 ttattaacga aagatggcat ggccaaacga ggagagtttg agacagtcca tggtacgata
     2221 cagactcctg tttttatgaa tgtaggaaca gtaggagcaa tcaaaggtgc tgtaagcacg
     2281 gatgaccttc gtacaatcgg aacgcaggtg gagctgtcta atacctatca tcttcatgta
     2341 agaacaggtg ataaactaat caaacagttt ggcgggcttc ataaatttat gggatgggat
     2401 aaaccaatcc ttaccgattc tggcggattt caggtgtttt ctctgtcagg tcttcgaaag
     2461 ataaaggaag aaggcgtata tttccagtca catattgatg gacatcatat ttttatggga
     2521 ccggaagaaa gtatgcagat tcagtctaat cttggttcta cgattgcgat ggcatttgat
     2581 gaatgtcctt caagtcgggc agacagaacc tacattcaga attctgttga cagaacaaca
     2641 agatggttag aacgctgtaa aaaaaagatg caggaattaa acagcctgcc agataccgta
     2701 aatccacacc agatgttatt tggtattaat cagggtggtg tttttgcgga tatccgtatc
     2761 gagcacgcta aaagaatcag tgagcttgat ttagatggtt atgcagttgg cggacttgca
     2821 gtaggagaga cacatgatga gatgtactat atccttgatg aagttgttcc gtatctgccg
     2881 gaaaataaac caacttacct tatgggtgta ggaacgcctt caaatattat tgaggcagtt
     2941 gacagaggaa tcgacttctt tgactgtgta tatccttcca gaaatggaag acacggacat
     3001 gtgtatacgc atcatggaaa gttaaatctt tttaataaga agtttgaatt agacccccgc
     3061 ccaatcgagg aaggatgcca gtgtccgtca tgtcggacat acagcagagc ctatatcaga
     3121 cacctgctca aggcaaaaga gatgcttgga atgcgtcttt gtgttcttca taacctgtat
     3181 ttctataatc atttaatgga agaaatacgt ggagcaattg atgaacaccg ctacaaagag
     3241 ttcaaaaaaa ccacattaga aggttttttg acaccggaag aagaataccg gtaatatatt
     3301 atatagaaga ataacggagg taaggacatg ttattagcac agagtgcgag cgcaagctca
     3361 tctattacaa tgatcattgc atatgtcatt ctttttggag cgattatcta ctttatgaca
     3421 atccgtccac agaagaagca gcagaaagca gcagacgaga tgcatgcagg aatgcaggct
     3481 ggagacagcg tattgactac aagcggattc tatggcgtaa tcatcgacat catggatgac
     3541 actgtaatcg tagaatttgg taacaaccgt aactgcagaa tcccaatgca gaaagatgct
     3601 attgcagcag tggagaagcc aaatcttaca aagacagaag aagagtagtt tcggttagcg
     3661 ggacagacga aaaatgaaaa agcagatatc ctatatttgt gactctatca ctgcgggttg
     3721 aatgttcgcc tccgggttca cattcaatcc tcgctaaggc cacaaatata ggatatctgt
     3781 tttttgctaa attgaaagta ctctccagtt taacaaagac agaaattaag agaccgccaa
     3841 tatataaaaa atgcgcctta gagcaagctc ttaatgcgga cgagcattaa gagcgcagtg
     3901 atacgaagca ttttttatat attggcggtc tcttaatttc gtctcgcttg ttctaaacag
     3961 agaacccttt tcataggcta taaaaaagcc tttggtgcag cctatggatg gaatttcgta
     4021 taaaaaatgg atggagcgtg cagcaggcct gtttctttct gcattaattg cagtattact
     4081 cacaatgcta tttttagcag tgtttgcatt tgccatgttg aaaggtaatc tttccgcttc
     4141 cgtagaaaaa attggtttaa ttgttatgag tgtgatggct tgttttgtcg ggggattttt
     4201 gtgtgggaaa aagaatatga aaaaacggta tttatggggg cttggcgtag gtgttttata
     4261 ttgcttgttt tttggagtaa tacgcgtcgg gatggggcag gcatttgtga cagatacgac
     4321 agcatttttt acaatgatgc tttattgtgc ggcaggagga atgcttggag gaatgttaag
     4381 ctaaaaagtt cttttcttac gggagggttt gtgttataat aacctacaaa gtgtcatctt
     4441 agatgcttta catactagat catgaagtga ggaggcgtta ttaatgaaac gtgtaaagac
     4501 actgaccgga aacaaaactt acggtactac aatgtgtaaa ggtggatgtg gcgagtgcca
     4561 gacatcctgc cagtctgcct gcaagacatc ttgtacagta ggtaaccaga cttgcgagag
     4621 taataaataa ttagagagca caacaggaag aatgcttcct gatatatgct tgaagtaggg
     4681 tgaactgtct tttttgtcag ttcaccttat ctcttgtatg gaaaagtatg tttgcagaga
     4741 ttactttatt gtaagttgaa aatattgtat acaggaatgt tctgtattat atatctattt
     4801 taaagttagc aggacatatc ttcaaattaa aaatatattt tagaaaatta agtataaaaa
     4861 ctataaaaga aatagaaagg gatatttaac gtgattcacc agtataaaaa taatggatat
     4921 aatattgtca tggatgtgtg cagtggtgcc attcatgttg ttgatgatgt gacttatgat
     4981 gtcattgctt tatatgaaga aaaaagcttg gaagaaatag aaaatgaact ttcttacagc
     5041 aaggaagata ttgaggaagc atataaagag gtaacttctt taaaagaaga gggactttta
     5101 tttacagaag atatttacga agattatatt aaagaggtaa agagcagaaa gacagtagta
     5161 aaggcacttt gcctgcatat tgcacatgat tgtaatcttg cctgccgcta ctgttttgca
     5221 gaagaaggag agtataaagg acaccgtgaa cttatgagtg caaaggttgg aaaggctgcc
     5281 cttgatttcc ttgtagccaa ttctggaaac cgtcataatc ttgaagttga cttctttggc
     5341 ggtgagccaa caatgaactt cggtgttgta aaggaagttg tagaatatgg acgttctctt
     5401 gaagaaaaac ataacaaaca tttccgtttc actttgacaa ccaatggtgt gctgttaaat
     5461 gacgagatta tggaatttgc caataaagaa atggacaacg ttgttttaag tgtcgatgga
     5521 cgtaaagaaa tccatgatta catgcgtcct acaagaaatg gtaagccaag ctatgacctt
     5581 atcatgccga agtttattcg ttttgcagag tccagacatc agcagaaata ctatgtaaga
     5641 ggaacattta ccaatagaaa tcttgatttc tccaaagatg ttcttcatct tgcagactta
     5701 ggatttgaac agatttccat ggaaccagtt gttggacagc cagaagagcc atacgcaatt
     5761 caggaaaaag accttccaca gatttttgat gagtatgaca gacttgcaaa agaaatgatt
     5821 aagagagaaa aagcaggaaa aggctttaat ttcttccact ttatgattga ccttacaggt
     5881 ggtccatgtg tagcaaaaag actttccggc tgtggaagcg gaacagagta tttagcagta
     5941 acaccgtggg gagatttata tccttgccac cagtttgtag gagaagagaa attccttctt
     6001 ggtaacgttt ttgatggaat caagcgtacc gatatttgtg acgaattccg ttcctgcaac
     6061 gtatacacaa agaaaaaatg taaagactgt tttgcgagat tctactgtag cggcggctgt
     6121 cctgcaaact cttataattt ccatggaaca attgatgatt cttatgattt aagttgcgat
     6181 atggagcgta agagagtaga atgcgcaatt atgattaagg ctgcattagc agatacagaa
     6241 ggcgaagaag aatagatgga aaagtggttt atcgcttcaa aaagagcaga ttttaataaa
     6301 attggtgaga tatttcatat cagcccggta acggcgcgtc tgatgagaaa taggagctta
     6361 acaacagtta gggaaatgca gcgttatctt tatggctctc tgtctgattt atatgattct
     6421 catcttttga aagatgccga taagggagcg gaaatcataa aagagaagat agaaacaggc
     6481 aaaaagattc ggattatttc ggattatgat gtagatggtg tttcatcaaa ctatatttta
     6541 tatcagggat taaaacgctg tggtgcggat gttgattata agattcctga ccgtgtggaa
     6601 gacggttatg gaattaatga acatctgata gaaaaggcag caggggacgg aattgatacg
     6661 attatcacct gtgacaatgg aattgcggca gcagaacaga ttgcttatgg aaattcttta
     6721 ggactcaccc tgattgtgac agatcatcat gatattccgt ttcaaaggca agaagatgga
     6781 agcatttctt ataatttgcc gtcagccgct gccgttatta atccgaagca aaaagattgt
     6841 ccgtatccat ttgaaaatat atgcggagcg gttgttgtct acaagtttat tcaggtgctt
     6901 tacgatttgt ttggaattga ccgtagagaa agtgaagcat ttcttgagat tgcggcgatg
     6961 gcaacagtat gtgacgttat gccattgtgt gatgagaacc gtattatcgt aaaggaaggc
     7021 ctgcaacgga tacagcatac gaatattacc gggctgcaag ctttaattga ggcaaatcat
     7081 cttgaagaaa aaaagatatc ttcttatcac tttggattta ttctcggtcc gtgtattaat
     7141 gcttccggtc gtttgacctc tgcaaaagat gcgttagaac ttcttctatg cgaagataaa
     7201 gaactttgca ggcagaaagc agaagcactc acacagctaa atgcagagcg aaaagaaatg
     7261 acagctaacg gggtaaaagc tgcaaaagaa tatctcgaaa gcaccggaca tggaaacgat
     7321 aaggtacttg ttgtatatct tccaaactgt cacgaaagta tcgccggaat tattgccgga
     7381 agaatgaaag aacattacca taagccagta tttgtcatca caagaacaaa agaaggatta
     7441 aaaggctctg gccgttctat cgaagcctat catatgtata aggaaatgaa caaaatcaag
     7501 gaatgtttcg ataaattcgg tgggcacccg atggcagcag gattttctat gcaggaagac
     7561 cgcttagaag aattccggga aaaattaaat gccaacgcaa cccttaccga ggatgatttc
     7621 gcagaaaaag ttcacattga tgtagccttg ccgatatctt atttatccga aagtctcatc
     7681 aatgaatttg aattactaga accatttgga aatgaaaaca caaaaccgct ctttgcacaa
     7741 aaagaccttt acataaaagg aatgcgggta ctcggaacaa caggcagatg tttaaaactc
     7801 ttcctgtcgg atgccaatgg aacaagcata gatgccatgt attttggaga atccgatgga
     7861 tttttagaag aactcatctc tttttgtgga aaagaagagg cacagagaat tcaaaaaggc
     7921 ctgtcacatc atatatggat ggatgtgact tattatccac aggtaaatga atggcgaggg
     7981 cagaagaata tccaaatcgt catccagaat tatcgtttta aaaatttatg agataaattt
     8041 tttagtgctt ctttcgcata ttttttcgtc tatttagatt cccaattaat aaaaactatc
     8101 ctaatttgac aaataaggcg agaatcaata gaataatatg aggatgaaaa gagagataca
     8161 tcaaaatcgc tatgaattaa gagatagata aggagaaaat atggaacagg agaaaaaaca
     8221 gccagatgtc agattgatag gattagattt agatggaaca acgctcactt cagataaggt
     8281 gttaactcca catacaaagg aagtacttga gaaatgtctt gcggaaggga ttcaggtttt
     8341 accggcaaca ggaagagtaa aatcgggtat tccagagtat ttaacacaga ttgaagggat
     8401 gagatatgtt attttatcca atggtgcaag tgtattagat ttaaaagagg ataaagttct
     8461 ttatcagaat tgtattccgt gggagagagc attggagtta ttcgatgtgt tagaaacata
     8521 tgatacattt tatgatattt atgcattagg agctggctgg tgtgaggctc gcttttatga
     8581 taatgtagaa aactatggaa ttgagaaaca tatcgagaag ctggttcgta catcacgcaa
     8641 tcgtattgat gatttaagag agtggatgaa agaaaataaa gctccagtgg agaagataaa
     8701 tatgttcttt gcaaaggaag aagacagaca gagagctttc cgtgaacttg gaaagataga
     8761 agatttggcg gttacctgtt ctcttggtaa taatcttgag attaatgggg caacttgtaa
     8821 taaaggagat gcgatgctca atcttggaaa aattcttgat attccgatag aaagtattat
     8881 ggcgtgcggc gatggcaata acgattttga gatggttaag atggctggtg tcggtgttgc
     8941 tatgaaaaac ggagaagagt ctttgaaaga ggttgcagat tttgtgacaa agacaaatga
     9001 tgaggaaggc gtagcatacg ctatcgagca tttttgtaat gtgtaagtag aaataaacgt
     9061 ttttctgttg ttttttacat aaaaaatctg ttataattaa tcataagaag aaaaagcgcg
     9121 aagataaaag tctgtgctta atagttttat gcctgatttg ggggcagaaa gggtggacaa
     9181 agtgaaaaaa cttgaagatt atgtcattaa tattccagat ttcccaaagc cgggaattat
     9241 tttcagagat attacctcta ttttacgtga tccggaggga ctgaaactta gcgtacatga
     9301 attgatgcat tgcttagagg gaacagagtt tgacgtagtt gttggagcgg aatcccgtgg
     9361 atttttattt ggtatgcctc ttgcttacaa taaaagcaag ggatttgttc ctgtccgtaa
     9421 gaaaggaaag ctgccaagag agactgtaag caaagaatat gctttagagt atggaacagc
     9481 agagattgaa atccataaag aggacattcg tccaggacaa agaatcgtat ttgtggatga
     9541 ccttttagca actggtggaa cagcaaaggc tgcgattgat ctgatcgaag aacttggtgg
     9601 cgttgtcgta aaggttctgt ttgttatgga acttgaggga ttgcatggcc gtgatgtatt
     9661 aaaaggctat gatgtagagt ctgttattac ttatcctgga aagtaatttt gaaggaaaag
     9721 aaactgtgtg gatggaattt tttggaagca cagtttctct ttgtgtaaaa attgttctgt
     9781 agttataaag ttgaatttct atttgcaatt tcttccttta aatcctgcat tttgctttac
     9841 aaaaagaaga aaatggagta ttatgaaata tacttaattt tacagaatag gtggaagaat
     9901 agagtggaac atttaaattt attacagaga atagagaaga agtcttccga gttcagtaaa
     9961 ggacagagaa gactggctca gtatattaca gagaactatg atattgcggc atatcttacc
    10021 gcttcaaagc ttggaaagga agcaggagtc agtgagtcta cagtggttcg ttttgcttat
    10081 cagcttgatt acgagggata tccagagcta cagaaggcaa ttcaggttat tgtaaagaca
    10141 aattcaaact ccattcagag aatgtccctt tcctcaaaaa gatatcagga aaaaggtgta
    10201 ttaaagagta ttttgtatac agatgcagag cggcttcgcg atacgattca gagcggtgta
    10261 gatgaggaag aatttaacag atccgttatg cttatcaatg atgcaagaag attatatatt
    10321 ttaggtgcga gaagtgcagc ttatcttgcc ggtctgatgg gatattattt taagatgatg
    10381 tttgacaatg taattatcgt agatgccaac agcacgtccg agacattaga gcagatttac
    10441 gatatcagtg ataaggatgt tatgatggga attacttttc caagatattc aaagagaacc
    10501 atctgtgcgc ttcagtatgc gaagaatcat ggagcgaaga caatcgcact taccgacaat
    10561 atgcagtctc caattgtaga gtatgcagat tgtaaattaa ttgcaaagag tgatgtaatg
    10621 acaatcgtgg attctttagt atgtccgtta agtgtggtga atgcgatggt tacagcgatt
    10681 gcattacttc gtaaggatga tgtagagaag cgtcttatgg cacttgaaga actctggaac
    10741 gagtatgatg tttataacag gagtttacta taatgaacaa agtaattatt gtaggcggag
    10801 gggcagccgg tatgatggct gccatttctg cgtctaaaga ggggaaaaag gtctgcattc
    10861 ttgaaaagaa cgaaaaactt ggcaagaagc tttttattac ggggaaaggc agatgcaata
    10921 ttacaaatgc ctgcccggca gacgaatttc ttacccatgt ggtaacaaat ccaagatttt
    10981 tatacagtac attttcgcag tttaataatg aggatatgat ggactattta gaagaaatcg
    11041 gtcttccgat aaagacagag agaggacaga gagtatttcc acagtccgac cggtcttcgg
    11101 atgtaattga tgcattaaag aaacagtgta aaaaaggcgg ggtacagatt tactatcaca
    11161 cagaagtaaa agaactactt tttgatgaag aaaaagaaaa ctgtgtcggt gtacttttgt
    11221 ctgacggaaa gaaaatgatg ggagattctg ttatccttgc ctgcggcggc ttttcctacg
    11281 cttctaccgg ttccaatgga tcgggataca cacttgcaaa gcaagcagga cataagatta
    11341 agtctataga accatcttta gttccatttg agatgaaaga aatgtggtgc aaagatttga
    11401 tgggacttac tttaaagaat ataggggtgc gtatcaaagc aaagaaaaag acagtttatg
    11461 aaggatttgg agaatttctc tttacgcatt ttggagtgag tggtccgctt gttcttacgg
    11521 caagtacctg tcttggcaaa tatcagaaag agttagaggc aggcgaatta aaactgattc
    11581 ttgatttaaa agcctctctt accccggaac agttagataa acggttttta agagaatttg
    11641 acacttatcg taataaaaat atttctaatg tgatggaacg tcttcttcca aagaaaatga
    11701 ttcctgtttt cttagaagaa gcacaaattc cggaagataa aaagataaga gacatcagca
    11761 aaaaagaaag aaggcatatg attgagctga tgaagaattt cgagatgcat atcacaggag
    11821 tccgtggctt taatgaggca atcgtcacga gaggcggagt aaatgtaaaa gaaattaatc
    11881 cgtctacaat ggagtctaaa aaagtaaaac atttattttt tgccggagaa atgatggatt
    11941 tagatgctgt cacaggcggc tataacctgc agattgcatg gacaacaggc tacgtagcag
    12001 gcaaaaatgc gtaaagaaaa cgtaaaattt aaaaaattat aaaaaaatag tttttttttt
    12061 cggaaaaata tgttacacta atcaagtgta ggtaaaagtg aaatcactgt atacgcagtc
    12121 aggtttcaaa agaatgggag gaaatgtcca tgtatagtat agcaattgat gggccagcag
    12181 gagctggaaa gagcacgatt gcaaaggcaa tcgcagaaga tataggtttt atatatgtag
    12241 ataccggagc aatgtaccgg gcaatcgctt tatatttttt gcgtaaaggt attgatggac
    12301 atgacaggaa gctcgttgcg gcagaatgtc ctaacattca tgtaacttta gaatatgacg
    12361 aggaagggaa acagcaggtt atcttaaatg gtgagaatgt taccggatat atccgtaagg
    12421 aagaagtcgg taagatggca tcagtgacat ccgctgttcc agaagtaaga gctgcactgc
    12481 ttgatctgca gcgcgatatg gcgaagactt cggatatcct catggatgga agagacattg
    12541 gaacgaatgt cctgccagat gcatctctta agatttatct gacggcctct gctgatgtaa
    12601 gagcgaagag acgttatgac gaattgaaag agaaaggtgc agactgtgat atcgagcaga
    12661 ttaagaccga tattatagca agagataagc aggatatgga gagagagatc gctccattat
    12721 gccaggcaga agatgccata ctggtagatt cttctgatat gtcaattccg caggtgattg
    12781 atacgattat ctccgaattt aaaaaaataa aataatattg ccggagtaaa tgatgaaaat
    12841 taacatagca aaatctgctg gcttttgttt tggagtaaag agagctgtag ataccgtgta
    12901 taaagaatct tcgaagaaga atgtttatac attcgggccg atcattcaca atgatgaagt
    12961 tgtcgcagat ctggaaagac aaggggttca tgtcatcaat gacagtgaag atttcaagtc
    13021 tctttcagag ggaacgatta ttattcgttc tcacggcgtg tcaaaagcaa tttatgatga
    13081 gatccttaat gcgggtcttg atttagtgga tgcgacctgc ccttttgtga gaaagattca
    13141 taaaatcgtc gagcgggaga gtggggatgg cagagtaatc attattatag gcaataacca
    13201 tcatcctgaa gtagaaggga ttatgggttg gtgccatacg catccgattg taattgagaa
    13261 tcgagagcag gcagaaggaa ttgagttaga tgctgatacg aagatatcta tcgtgtccca
    13321 gacgacattt aactacaata agtttcaaga tttagttgaa attatctcag aaaagggtta
    13381 tgatataaat gtttttaaca cgatttgtaa tgcgactgag gagcgtcaga cggaagtcag
    13441 ggaactggcg aagaagtccg atgcgatgat agtaatcggt ggcagacaca gttcgaatac
    13501 tcaaaagctt tttgagataa gtaaaaaaga atgtagtaat actttttata tacaaacaaa
    13561 aaatgatttg aatatggagg atttttctaa tatcgggatg ctcggtatta ctgcaggggc
    13621 ttcaacccca aataatatta tcaaggaggt tcatgaaagc atggcagaaa tgagttttga
    13681 ccagatgctg gaagaaagtt ttaagacaat cagaaatgga gaggtagttc agggtactat
    13741 tatcgatgta aaagaggatg aaatcatctt aaatattgga tataaagccg acggtatcat
    13801 ttcaagaaac gaatattcca acgaccagaa tttagactta acaacagttg ctaaagttgg
    13861 tgacgagatg gaagctaaag ttcttaaagt gaatgatggc gaaggacagg ttctcttaac
    13921 atataagaga cttaaagcag aaaaaggtaa taagagatta gaggaagcat ttaacaacca
    13981 cgaagtatta aaagctcctg tagctaaagt tcttgacggt ggtttaagtg ttgtagtgga
    14041 agaaacaaga gtattcatcc ctgcaagcct tgtatccgat acttacgaga agaacttaaa
    14101 gaaatatgac ggacaggaaa tcgagttcgt tatcacagag ttcaaccctc gcaagagaag
    14161 aatcatcggt gaccgtaagc agcttttagt agcagagaag aaagcaaaac aggaagcact
    14221 gtttgcaaaa atcgaagctg gtatgactgt agaaggaact gtaaagaacg taacagattt
    14281 cggtgcattc atcgatttag gtggagcaga cggacttctt cacatctccg aaatgagctg
    14341 gggacgtgtt gagaatccta agaaagtttt cacagtaggt gaaaaattaa acgttcttat
    14401 caaagatatc cagggagaaa agattgcatt atccttaaaa ttccctgaaa caaacccatg
    14461 gcttcacgct gacgaaaaat acgcagtagg taacgaagta actggtaaag ttgctcgtat
    14521 gacagacttc ggtgcattcg ttgaattaga gccaggcgta gatgcattac ttcatgtttc
    14581 tcagattgct aaagagcaca tcgagaaacc atctgatgta ttaaaagtag gtcaggaagt
    14641 tacagctaaa gttgtagatt tcaagaaaga tgatcgtaag atcagcttaa gcatcaaagc
    14701 tttagataac gaataatatt tagcggaatt tggctaggta gacgaaaata aaaaagactt
    14761 ataatagcac ctgtgacttt agtcgcggca tgttgaatgt tcgcttaagg gctcgcatcc
    14821 aacacttgct ccgaggtcac atctgctatt ataagtcttt ttcattttct gactttggcg
    14881 caaattccgc tgtggaggat ttgaggattc tccagaagag gatgggagtg ggtggaaaat
    14941 tttcttcgtt atagttaatg tttcactggc attttatata attttgctat aaataaaact
    15001 tcttataagt ataatatata ttatgtgaaa atttatatag aaagcatttt taagtccaca
    15061 tttaaaaaag caggaattag atttctgcaa ttctcacttt aatttatcaa aaaacagaaa
    15121 aaagccccta ttaatcctcc cagatgtgac ctcggagcaa gtgttggatg cgagcctttt
    15181 agcgaacatt caacacgtag cgactaaagt cacatctggg a
//
