LOCUS       c00045_gnlPro..        14419 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AGOJHKEG_45.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:32:14
            Original ID  :: gnl|Prokka|AGOJHKEG_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14419
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14419
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:4419]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..4419
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14419
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14419
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..871
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_1"
                     /sec_met_domain="CT_Vparvula (E-value: 4.3e-71, bitscore:
                     230.9, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="FQSEQAGNVDFVCETEEGLLDQLRILVDVLPSDYEAEDVYFDNDD
                     DLNRVIPELNDAAYDAAYILKSISDNNMYIETKAAYAKEMVTAFIRLNGETVGAVANQP
                     VDGESVLTRNGLEKAERFIKFCDAFSIPLLTVTNVTGLRANAHEERKQALALAKFTTTL
                     AQVSVPRINLIAGEAYGTAAEVMNSKAIGADFVLAWPQASVGMMDAEQAVRIMYAEEIN
                     TDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRKRLIAAYEMLYGKKVTP
                     VTKKHTAV"
     CDS             884..1228
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_2"
                     /sec_met_domain="OAD_gamma (E-value: 1.3e-27, bitscore:
                     87.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSADKLV
                     VRSIKRVKRR"
     CDS             1323..1691
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.6; E-value:
                     4.3e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2e-21, bitscore:
                     66.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEASAAPVSTPAAVPAPAKKAAP
                     KTSGSAGAVKITAPMPGKIVAVKAQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             1725..2849
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_4"
                     /sec_met_domain="OAD_beta (E-value: 2.6e-157, bitscore:
                     514.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVST
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGAEA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             3007..4419
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_5"
                     /sec_met_domain="HMGL-like (E-value: 1.7e-43, bitscore:
                     139.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 8.9e-59, bitscore:
                     189.5, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDACLRFLKEDPWERLRKLRDGFKNTKLQMLFRGQNILGYKPYPDDVVE
                     YFVQKSIANGIDVIRIFDCLNDLRNLQTAVDATKKEGGHAQIALSYTIGDAYTLDYWKK
                     TAKNIEEMGADSICIKDMAGLLVPNEATRLVTALKQATDIPIELHTHYTSGVGGMTYLK
                     AVEAGVDIIDTAISPFAMGTSQPATEVMAETFRGTEFDTGFDQKLLGEIADYFRPIREK
                     YIANGLMSPKVLGVNIKTLMYQVPGGMLSNLVSQLEQQGASDKFYEVLEEVPKVRKDFG
                     EPPLVTPSSQIVGTQAVLNVLTGERYKMITNESKALLRGEYGQTVKPMNKEVQKKAIGD
                     EKPITCRPADLLEPELSKIEAEMSQWKEQDEDVLTYALFPQVATEFFKYRAAQENKIDP
                     AKADVKNGAYPV"
     CDS             complement(4576..4680)
                     /locus_tag="ctg45_6"
                     /transl_table=11
                     /translation="MAIILSFGNTAIIDYNILNKAANTIASPIHFRQV"
     CDS             complement(4680..5069)
                     /locus_tag="ctg45_7"
                     /transl_table=11
                     /translation="MKKLFYPAVFHIAEEGGYWVTFPDFPECLTQGENMQEAYDMAIDA
                     LGLILTDDINDHKELPEPSNITHVDDGVVVIIPYDYLEYNRKYHNKSIKKTLTIPEWLN
                     NEALRLNLNFSQILQDALLNKIQSR"
     CDS             complement(5115..5303)
                     /locus_tag="ctg45_8"
                     /transl_table=11
                     /translation="MPMKPKEMIRLLKKNGFIKISQNGSHVKMKNFKTGKQTTVPLHSK
                     DLKKRLEDAILKQAGLK"
     CDS             5528..5671
                     /locus_tag="ctg45_9"
                     /transl_table=11
                     /translation="MNNAVSYAMDSQVIFQMFFSIVCIAAAIGVSILVLRFMRKFIDFL
                     LQ"
     CDS             complement(5720..6748)
                     /locus_tag="ctg45_10"
                     /transl_table=11
                     /translation="MIPIQNIYYMLSYAFQTLQAENYKDLATENFHNTAELCAAILDKG
                     IGIQLKHGLRRDYVSKSESLSTLQGKLNISESIKTQTMLKKQMICTYDEFSTNIQFNQI
                     IKSTVLLLLKANITNSRKKSLRKLLLFFSDVNEIDLHFVNWNQQYNRSNQNYQMLIGMC
                     YLVYKGLLTTQNNGTTKLMDFFDGQRMCRLYEKFLLEYYRKEHPELTANASQIAWQLDD
                     TENQMLPRMQTDIMLSKNNNILIIDAKYYSHMTQQQYGIHTLHSNNLYQIFTYVKNKEF
                     ELRNYEHTVSGMLLYAQTDEDIIPNNTYHMSGNQISVLALDLNQDFSKISRTLDDIAKN
                     FL"
     CDS             complement(6745..8454)
                     /locus_tag="ctg45_11"
                     /transl_table=11
                     /translation="LVEGAEIISSFGPLNSTADYEQLYKQLEHISGINTVWRMKYYQML
                     FPILFAPFYGQDIQLDVLHFLNQTPSEIPFIRMGQIALFSKKCNIPGIVFGHIWGRSTN
                     HNNKSNDSETNTLSDKKHKLHYWMYTVFDDTSWMECQQKEIMVLGMNDIGDYSQYDSKE
                     SLRQELISTYDNSTSRKNQALMAWNFANKLAINDVIFAKRSNTLVGKGIVTGDYIFDDS
                     RQEYKNIRTVKWLQIGEWEHPGKSVAKRLTDITSYTDYIEKLITIFTPDELDDVDTQPE
                     VDYPEYSSADFLSDVYMSEQDYETLVNVLKMKKNIILQGAPGVGKTFTAKRLAYSIIGA
                     KNPDRVQMIQFHQSYSYEDFIEGYRPTENGFTIKKGSFYKFCKLAEDDDENDYFFIIDE
                     INRGNLSKIFGELFMLIEKDKRGIELQLLYSDENFSVPPNVYIIGMMNTADRSLAMLDY
                     ALRRRFSFFTMKPGFNTIGFQTYQDSLKSDAFKKLISCIKQLNSKIAADISLGEGFCIG
                     HSYFCGLTAKTATVRTLTSIIEYELIPLLKEYWFDEPEKIIDWSDRLRSTVK"
     CDS             8520..8789
                     /locus_tag="ctg45_12"
                     /transl_table=11
                     /translation="VSHKSSFVFFCERKVQIYKLLHRQYFQIFRAYLCPFQVHNKDSIY
                     FLFHFRLFIRKIHFTSLSFYVMFIYDYAIFYGCFLSVENGTKKQ"
     CDS             8826..9974
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_13"
                     /sec_met_domain="Aminotran_5 (E-value: 1.3e-78, bitscore:
                     255.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIYFDNGATTRALPQVREIMDEVLEKEYGNPSSMHMKGFDAEK
                     YVNHAKEIIAKSLKVDPKEIYFTSGGTEANNLALIGTAFANKRERKHIITSCIEHASVY
                     NPLSFLEDEGFEVTYLPVDEHGIVDLEALKKALRKDTLMVSIMCVNNEIGAIEPVEEIG
                     KIVKSFDPKILFHTDCIQAYGKLNCYPKKWKADMISVSGHKIHGPKGIGFIYIKNGTKI
                     KPIIWGGNQQKGMRSGTENVPGIAGLGKAAELIYENHEEKIAHIREIKDHFIKRVMEEI
                     PDVKDNSGDAPHVASISFLGVRSEVLLHALEEREIYVSAGSACSSNKPEVSGTLKGIGL
                     TKEYYESTLRFSFSIFNTVEEADICVEALKELLPMLRRFTRR"
     CDS             9990..11255
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:Thiamine biosynthesis protein (Score: 226.4;
                     E-value: 8e-70)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_14"
                     /sec_met_domain="ThiI (E-value: 3.7e-70, bitscore: 226.4,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSRNLFELDFVTKKTTRVHHIKKEIFMKFKAFLIKYAEIGIKGN
                     NRRFFEDALVRQMKYALKPVGDFSIRKESGRIFVHANEEYDFDEAVESLSHVFGIAGIC
                     PIVVEEDKDFEKIAEVVEKYVDEDYADKHFSFKVHVRRADKKYPIPSMEAAARLGERLL
                     EKFEDLSVDVHNPDVMLTVEIRDKVYIYSREIPGPGGMPVGTNGRAMLLLSGGIDSPVA
                     GYMISKRGVSIDATYFHAPPYTSERAKQKVVDLAKEIAKYTGPITLHVVNFTDIQMAIY
                     EKCPHDELTIIMRRYMMKIAEHFANQDNCLSLVTGESIGQVASQTMHSLYVTNEVCQMP
                     VFRPCIGLDKNEIVKVAEKIGTYETSILPYEDCCTIFVAKHPVTKPRLDVIKRSERNLD
                     DCIDELMKTAIETTEEIKINAH"
     CDS             11218..11457
                     /locus_tag="ctg45_15"
                     /transl_table=11
                     /translation="LKQQKKLRLTLTKVLMDESIFKADISILIMFIMLADKCLFKRWEE
                     EISLKIFVLSEDSYKKNLSVKKEPRKVIFPRLIS"
     CDS             complement(11515..11880)
                     /locus_tag="ctg45_16"
                     /transl_table=11
                     /translation="MPKNSPLSLDNIFQIFLKSIDFFSLKRYYIIKIYIDIFRRSAYMK
                     TIKISLNSIDKVKTFVNVINRFDAEFDLVSGRYVIDAKSIMGIFSLDISKPIDLNIHNA
                     DNLDEIMEQLQPYLVTE"
     CDS             11984..13336
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_17"
                     /sec_met_domain="Radical_SAM (E-value: 1.7e-29, bitscore:
                     94.3, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKRRAAFLTLGCKVNQYETDAMEEILEKAGYEIVSFKETADVYI
                     INTCSVTNMADRKSRQMIHRAKKNNPDAIIVAAGCYVQAAEEELAKKNEADILVGNNKK
                     KDIAQILEEYFAAKEPEQEVPVVSEVIDINHTKEYEDLIIHKVNEHTRAYIKIQDGCNQ
                     FCSYCIIPYTRGRIRSKNPEEVIEEVKNLAAQGYKEIVLTGIHLSSYGKDLGTVNLLDV
                     IKRIQQIEDVERIRLGSLEPRIITEEFVKELVKCDKVCPHFHLSLQSGCDQTLKRMNRK
                     YTTEEYEEALNILRKYYEHPALTTDVIAGFVGETEEEFEKTRAYLEKINLYEMHIFKYS
                     VREGTRAQKMSGHVPEQVKTERSEVLLSMAKRHKTAFEEWYVGRKEKVLLEEIVEKNGK
                     KYFQGYTAHYVKVAVELTENDTKLEQNEVIVVDIQGFIDENLLYGKVSIEF"
     CDS             13391..13648
                     /locus_tag="ctg45_18"
                     /transl_table=11
                     /translation="MGRNNTQFFHVVKEQEYDVASILKDVYEALTEKGYNPVNQIVGYI
                     MSGDPTYITSHKNARSLIMKVERDEILEVLFENYIDTQLK"
     CDS             13651..14088
                     /locus_tag="ctg45_19"
                     /transl_table=11
                     /translation="MKERWMGLDYGTKTVGVAVSDVLGITAQGVETVTRKSNKKLRQTL
                     ARIEALIEEYEVSKVVLGLPKNMNNTLGERAEETKEFQAMLQRRTGLEVVLWDERLTTM
                     ESERILQEGGVRRENRKERIDWMAATLILQSYMDAHPIPEK"
     CDS             14128..14415
                     /locus_tag="ctg45_20"
                     /transl_table=11
                     /translation="MNNYQSIPFKDEDGKEKEFYVLEQTTLNGFHYLLVEDGSADADDE
                     EVEVLIMKRVADAAEDEEWATYEMVEDEEELISVSKVFEQLMDDINFEVE"
ORIGIN
        1 gttccagtct gagcaggctg gtaacgtaga ttttgtatgt gagacagaag aaggacttct
       61 tgaccagctt cgtattctcg ttgatgtact tccttctgat tatgaagcag aagatgttta
      121 ctttgataac gatgatgatt taaatagggt tattcctgag ttaaatgatg ccgcatatga
      181 tgccgcttac attttaaaat ctatttctga caacaatatg tacatagaga caaaggcagc
      241 ctatgccaaa gagatggtga cggcatttat ccgtctgaat ggagagacag taggtgcggt
      301 tgctaaccag ccagtagatg gtgagtccgt tttaacaaga aatggtcttg aaaaagcaga
      361 aagatttatt aagttctgtg atgcattttc gattcctctt cttactgtaa cgaacgtgac
      421 aggacttcgt gccaacgcac atgaagagag aaagcaggcg ctcgcattag cgaagtttac
      481 aacaacactt gcacaggtta gtgtacctcg tattaatctc attgcaggcg aggcttatgg
      541 aactgcagcg gaagtaatga attctaaagc tatcggagct gactttgttc tggcatggcc
      601 acaggcatct gtaggaatga tggatgcaga acaggcagtt cgtatcatgt atgcagagga
      661 aatcaataca gataagaata agacagcact tatcgcagag aaaactgcgg aatatgcaga
      721 aggacagagc agtgcattag cagctgcaaa gagaggatat atagatgaca tcatcgagcc
      781 ggacgcaaca agaaagcgtc ttatcgctgc ttatgaaatg ctttacggaa agaaagtaac
      841 tccagtgaca aagaagcata cggcagtata gtgaggtgag agtatgaacg tatttgaaca
      901 agccttatta aatactttga tgggtatggg aactgtattt gcagtactga ttttcatttc
      961 tttactgatt tctctttttg tatatatccc atctattgaa agagcgttaa agaatcgttc
     1021 ttctaagaaa gagaaaaagg ctgcgcagga agaaagaccg gctccaaagc gtccgattct
     1081 tgaagaagtt gtggaagaag aggaacttgt ggatgatggt gaacttgtcg cagtaatcac
     1141 agcggcaatc atggcagcga atggaggagc agcagtcagt gcagataagt tggtcgttcg
     1201 ttcaatcaag agagtgaaga gaagatagca aaaatgtatt cttggaatct ttttataaag
     1261 ttttgaaaag ttagctatag aaagatttta gaagtacata aaatcattca ggaggattta
     1321 aaatgaaaaa ttatagaatt acagttaatg gtgttgctta tgatgtagca gtagaagaat
     1381 taggtgcagg agaagcaagt gcagcgccgg taagtacacc agcagccgtt ccggctccag
     1441 ctaagaaagc tgccccaaag acttccggaa gtgccggtgc cgtaaagatt acagcaccaa
     1501 tgccaggtaa gatcgtagca gtaaaggcac aggcaggtgc ttctgtaaag aagggcgacg
     1561 ctgttcttgt attagaggct atgaagatgg agaatgaaat ctgtgcagca caggatggtg
     1621 ttatcgcaag tgtggaagta gcagttggag atatggtaga aggcggagat gtactggcta
     1681 caatgaacta gagcatattt gcaaaataaa acggaggaag atttatgagt tatgttgtag
     1741 agacaatgac gaatctcgca gcacagaccg gatttgcatt cttaaagcca ggtaacttca
     1801 ttatgatact ggttgcttta gtcttcttat atctggccat cgccaaagga tatgagccac
     1861 ttttgttagt gccgatttct tttggtatgc tgctggttaa cttatatccg tccattatgg
     1921 aagaaggcgg attattacat tatttttact tattagatga atggagtatt ctcccttcac
     1981 tgattttctt aggtgttgga gcactaacag actttggtcc gctgattgcc aatccagcaa
     2041 gtttcttgct gggagctgcg gcgcagtttg gtatttacag cgcgtatttc cttgcaatgc
     2101 ttatgggatt taacggaaag gcagcagcag caatttccat tattggtgga gccgatggtc
     2161 ctacttctat tttccttgcc ggaaagcttg ggcagacaga cttaatggga ccaattgcgg
     2221 tagcggcata ttcttatatg tcacttgtac caattattca gccaccgatc atgaagctcc
     2281 ttactacaga aaaggaacgt cagattaaga tggaacagtt aagaaccgtt acaaaaacag
     2341 agaaaattat gttccctatc gttgtaacag ttgttgtatg tctgattctt cctacaacag
     2401 caccattagt tggtatgctg atgctcggta acctttttag agagtccggc gtagtaaaac
     2461 agctttcaga gacagcgtct aacgctctta tgtacatcgt agttattatt cttggtacat
     2521 ccgttggtgc gacaacaagt gcagaggcat tcttaaatgt cagcacaatc aagattgtag
     2581 tattaggtct tgtagctttt gctgttggta ctgcagcagg tgtcctgttt ggtaaactta
     2641 tgtgtaaggt tacaggtggt aaggtaaatc cattaattgg ttctgccggg gtatctgccg
     2701 ttcctatggc agcccgtgta tcccagaaag ttggtgcgga agcagatcca tcaaacttct
     2761 tactgatgca tgcgatggga ccaaatgttg ccggagttat cggtacagcg gtagccgccg
     2821 gaacatttat ggcaattttt ggagtataat ttagaattat ttgattattt aaaattcatt
     2881 atttataggg ctacaatctg taaaaaatgt tacaggggat atttataaat agtttacaag
     2941 ttgaatttta gataataaca gttgtaagcg caaatagtta cgtgatttga aataaaagga
     3001 gatattatgg ccgaaattaa gaaaaaaccg gttaaaatag tagaaaccgt tctccgtgac
     3061 gcacatcagt ctctgattgc tacaagaatg acaacagagg agatgctgcc aatcgtagat
     3121 aagatggatc aggttggtta tcatgcagta gaatgctggg gaggtgcaac atttgatgcc
     3181 tgcctgcgtt tcttaaagga agacccatgg gagagacttc gtaaattaag agatggcttt
     3241 aagaatacaa agttacagat gttattccgt ggacagaaca tcttaggata taagccatat
     3301 ccagacgatg ttgtagaata tttcgtacag aaatctattg caaacggaat tgatgttatt
     3361 cgtatttttg actgtttaaa tgaccttaga aacttacaga ctgctgtaga tgcaacaaag
     3421 aaagagggag gacacgcgca gatcgccctc tcctatacaa tcggtgatgc atatacatta
     3481 gactactgga aaaagactgc taagaatatt gaagagatgg gagcagattc tatctgtatc
     3541 aaagatatgg caggactttt agtgccgaat gaagcaactc gccttgtaac tgcattaaag
     3601 caggcaacag acattcctat cgaacttcat acacactata caagtggtgt cggtggaatg
     3661 acttacttaa aagcagtaga agcaggagtc gatatcattg atacagccat atctccattt
     3721 gcaatgggaa caagccagcc ggcaacagaa gttatggcgg agacattccg tggtacagaa
     3781 tttgacacag gatttgacca gaagctttta ggtgaaatcg cagattactt ccgtccgatc
     3841 cgtgagaaat acattgcaaa tggcttaatg agtccaaagg tacttggtgt aaacatcaag
     3901 actttaatgt atcaggttcc aggtggaatg ctttctaacc ttgtatctca gttagagcag
     3961 cagggagcat ccgataagtt ctatgaagta ttagaggaag ttccaaaagt acgtaaagac
     4021 ttcggtgaac caccattagt tacaccgtcc agtcagattg tcggaacaca ggctgtatta
     4081 aatgtactta ccggagagcg ttataaaatg attacaaacg agtcaaaagc ccttcttcgt
     4141 ggagaatacg gtcaaaccgt aaaaccaatg aataaagaag tacagaaaaa ggcaatcggc
     4201 gatgaaaagc caattacctg tcgtccagcc gaccttcttg aaccggaatt atctaagatc
     4261 gaggcagaga tgagccagtg gaaagaacag gacgaagatg tgcttacata cgcattgttc
     4321 ccacaggtag caaccgaatt ctttaaatac agagcggcac aggagaataa gattgatcct
     4381 gcaaaagccg atgtaaagaa tggagcatat ccggtgtagg attggattga tttagattaa
     4441 aaacagacga acccccgcaa ctttatagat agcacatgtg aagatttcgc tgcgtagaaa
     4501 atgctcagcc gcatttttac ttgctccgac atcacatttg ctatctataa agttgtgggg
     4561 gttctgtttt ttaacctaaa cttgccggaa atggataggt gaagctatcg tattagctgc
     4621 cttgttaagt atattataat ctatgattgc agtattacca aatgaaagaa ttatagccat
     4681 taacgagatt gaattttgtt taaaagagca tcctgcaaaa tctgtgaaaa gtttaaattc
     4741 aatcgcaatg cttcgttatt caaccattca gggattgtta aagttttttt gatagattta
     4801 ttatgatact ttcgattata ttccaaataa tcatatggga tgattacgac aactccatca
     4861 tcaacatgtg tgatgttaga cggttctgga agttctttat ggtcgttaat gtcatcagtt
     4921 aagataagtc ctaaagcatc tatagccata tcataggctt cttgcatatt ttctccctga
     4981 gttagacatt cgggaaagtc aggaaaagtc acccaataac cgccttcttc tgcaatatga
     5041 aatacagcag gataaaataa ttttttcata atggatacct ccaatgtatg tgagttatta
     5101 tagatgaaat aaggctattt taagcccgct tgttttagga tggcatcttc tagtcttttt
     5161 tttaaatctt tgctatgaag aggaactgtt gtttgtttgc cagttttaaa attcttcatt
     5221 ttcacatggg aaccattttg acttattttt atgaaaccat ttttttttaa taatcttatc
     5281 atttcttttg gtttcattgg catagtatgc cacccctttc tataattata ttataatacg
     5341 tatagtatac gtgtgtcaag aactcggtga tacaactggt gaggaatagt atatcatatt
     5401 taagaagaaa aacaactaat aaatgtaaaa aaatataaaa aatgtaattt ttaaaatgaa
     5461 aaatttttga taaaaataca gagatatggt aaaatgaagt atcaaaagat agtcaggggg
     5521 agatacaatg aataacgcag tttcatatgc tatggatagt caggtgattt ttcagatgtt
     5581 tttttcaatt gtatgtatag cggcagctat aggtgtatcc attttggttc ttcgctttat
     5641 gaggaagttt atagattttt tgttacaata ggggtaatag aagtaaggaa gggatattag
     5701 gtcccttcct ttaaaaattt taaagaaaat ttttggcgat gtcatctaaa gttctggaga
     5761 tttttgaaaa atcctggttt aaatctaatg caagaacaga aatctgattt ccgctcatat
     5821 ggtaggtgtt attaggaata atatcttcat cggtttgtgc ataaagaagc attcctgata
     5881 cagtatgttc atagtttctc aattcaaatt ccttattttt tacataggta aaaatctgat
     5941 aaagattatt ggaatgcaga gtatgtattc cgtattgttg ctgggtcata tgcgaataat
     6001 atttggcatc aataataagt atgttattgt ttttggataa cataatatct gtctgcatcc
     6061 taggaagcat ttgattttca gtatcatcaa gctgccatgc aatttgtgat gcattggcgg
     6121 tgagttctgg atgttctttc cgataatatt caagcaagaa tttttcatat aagcgacaca
     6181 ttcgttgtcc gtcaaaaaaa tccatgagtt tagtagtgcc gttattttgt gttgtcagaa
     6241 gacccttata gactagatag cacataccga ttaacatttg atagttttga ttagagcgat
     6301 tatactgttg attccaattt acaaaatgca ggtcaatttc attaacgtca gaaaaaaata
     6361 gcaatagttt tcttagactc ttttttcggc tgtttgtaat attcgcttta agaagcagta
     6421 atacagtgga tttaataatt tggttaaatt gtatattggt tgagaattca tcataggtac
     6481 aaatcatttg ttttttgagc attgtctggg tcttgatgga ttctgaaatg ttaagttttc
     6541 cctgtagtgt agaaagagat tcggattttg atacataatc tcttcttaaa ccatgtttta
     6601 attgaatacc aattccttta tcaagaatcg ctgcacataa ttctgcagta ttatgaaagt
     6661 tttctgttgc taagtctttg taattctctg cctgtaatgt ttgaaaagca taggacagca
     6721 tatagtaaat attttgaatg ggaatcattt gacggtactc cttaatctat cagaccagtc
     6781 gatgattttt tcaggttcat caaaccaata ttcttttaaa agaggaatca attcatattc
     6841 tataatggat gtaagtgttc ggacagtagc tgttttggca gttagtccac aaaaatagct
     6901 atgcccgata caaaatcctt ctccaagaga aatatctgct gctatttttg aatttaattg
     6961 ttttatgcaa gaaatcaatt ttttaaaagc atcacttttt aaagaatctt ggtaagtctg
     7021 aaaaccaata gtattaaatc ccggtttcat agtaaaaaat gaaaaacgtc gtcttaaagc
     7081 ataatctaac atggcaaggc tacgatcagc agtattcatc atgccgataa tatatacatt
     7141 gggtggtaca gaaaaattct catcagaata taataactgg agttcaatac cacgtttgtc
     7201 tttttcaatc aacataaata attcaccgaa tattttactt aaattaccgc gattgatttc
     7261 atcaataata aagaaataat cattttcatc gtcatcctca gcaagtttgc agaatttgta
     7321 aaaagacccc tttttgattg taaacccatt ttctgtcgga cgatatccct caataaaatc
     7381 ttcataggaa tagctctggt ggaactgaat catttgaaca cggtcaggat tttttgcacc
     7441 aataatagaa taggcaagac gtttggcagt aaatgttttt ccaacaccag gtgcaccctg
     7501 taaaatgata tttttcttca tttttaagac atttaccaat gtttcataat cttgctcact
     7561 catatataca tcggaaagaa aatcagcaga agaatattct ggatagtcta cttcaggttg
     7621 tgtatctaca tcatccaatt catcaggagt aaagatagta ataagttttt cgatatagtc
     7681 agtatatgag gtaatatcag ttaagcgttt ggcaacagac ttaccgggat gttcccattc
     7741 gccaatttga agccacttta cggtacggat atttttatat tcctggcgag aatcatcaaa
     7801 aatataatct ccggtgacaa tacctttacc aacaagagta ttacttcgct ttgcaaaaat
     7861 gacatcattg atcgccagct tgtttgcaaa attccatgcc attaaagcct gattctttcg
     7921 agaggtactg ttgtcataag tgcttatcaa ttcctgacga agagattcct tagaatcata
     7981 ttgagaataa tctcctatgt cattcatgcc gagaaccata atttcttttt gctggcattc
     8041 catccaactg gtatcgtcaa agaccgtgta catccagtag tgaagtttat gttttttgtc
     8101 ggaaagcgta ttagtttcag aatcattaga tttattattg tgattagtgg atcttcccca
     8161 aatatgacca aaaacaatac caggaatatt acattttttt gaaaacagtg cgatttgtcc
     8221 catgcgtata aaaggaatct cgcttggtgt ttgatttaga aaatgtaata catccaattg
     8281 tatatcttgt ccataaaatg gtgcaaacaa tattggaaat aacatttgat aatatttcat
     8341 tcgccatact gtattaattc cagaaatatg ttccagttgt ttgtagagtt gttcataatc
     8401 tgctgtggaa tttaaaggac caaaggaaga tattatttca gcaccttcta ccaaatcatt
     8461 acgtatttct tctgcctttt ggattgcctc attttcagta agctttacag gttttgcagg
     8521 tgagccacaa gtccagcttt gtgttttttt gtgaaagaaa agtccaaatt tataagctgc
     8581 tccaccggca atacttccaa atatttcgcg catatctttg tccatttcaa gtacataaca
     8641 aagattcaat ttatttcctt tttcattttc gcctgtttat ccgcaaaatc cattttactt
     8701 ctctctcatt ttatgttatg tttatatacg attatgccat tttttatggc tgttttttga
     8761 gtgtagagaa tggaacaaaa aaacaataag acataatata ttttttgaag gagttgtaaa
     8821 cgagaatgtc agagatttat tttgacaatg gcgcgaccac aagggcgctg ccgcaggtgc
     8881 gtgagattat ggatgaagta cttgagaagg agtacggcaa tccttcttct atgcatatga
     8941 aaggatttga tgcagagaag tatgtcaatc atgcgaaaga gattattgca aagagcctga
     9001 aagttgatcc aaaggagatt tattttactt ctggcggtac agaggcgaat aatcttgcat
     9061 tgatcggtac tgcatttgca aataaaagag agagaaagca cattattaca agctgtattg
     9121 aacatgcttc tgtatataat ccattatctt ttttggaaga tgagggattt gaagtgacct
     9181 atcttcctgt cgatgaacat ggaatcgtag atttagaggc attaaagaag gcgcttcgta
     9241 aagatacatt gatggtttct attatgtgcg tgaataatga gattggtgcc atcgaaccgg
     9301 ttgaggagat tggaaagatt gtaaagtctt ttgatccaaa gattttattt cataccgatt
     9361 gtattcaggc atatggtaag ttgaattgtt accctaagaa atggaaagca gatatgattt
     9421 ctgtaagtgg acataagatt cacggcccaa agggaatcgg atttatttat attaagaatg
     9481 gaacaaagat aaagccaatc atctggggtg gaaatcaaca gaagggaatg cgttccggaa
     9541 cagaaaatgt accgggaatt gcagggcttg gtaaggcggc agagttgatt tatgagaatc
     9601 atgaggaaaa gatcgcacat atcagagaga taaaagatca ttttataaaa agagtgatgg
     9661 aagagattcc agatgtgaag gataattccg gagatgctcc gcatgtggcg agtatcagct
     9721 ttttaggagt aagaagtgaa gtgcttcttc acgcattaga agaacgtgag atttatgtat
     9781 cagcaggttc tgcctgttca tctaataaac cggaagtcag cggtactttg aagggcattg
     9841 gtcttacaaa ggaatactat gaatcgacgc ttcgtttttc attctctatt tttaatacgg
     9901 tagaagaagc agatatttgt gtggaagcgt taaaagaact gttgccgatg cttcggagat
     9961 ttacaagacg ataaaacaat tagaacataa tgtactctag gaatcttttt gagcttgatt
    10021 ttgtgacaaa aaagactacg agagtacatc atataaaaaa ggagatattt atgaaattca
    10081 aagcattttt gattaaatat gcagaaattg gaatcaaggg aaacaatcgc cgtttctttg
    10141 aagatgccct tgtccgtcag atgaaatatg cattaaaacc agtaggagac ttttctatca
    10201 gaaaggaatc tggacgtatt tttgtacatg ccaatgaaga gtatgatttt gatgaggcgg
    10261 tggaaagctt aagccatgta tttggtattg caggtatttg tccaattgta gtagaagaag
    10321 ataaagattt tgaaaagatt gcggaagtcg tagaaaaata tgtagatgaa gattatgcag
    10381 ataagcattt ttctttcaaa gtacatgtaa gaagagcaga caagaagtat ccaattccgt
    10441 ctatggaagc agctgcccgt cttggagaga gattattaga gaagtttgag gacttaagtg
    10501 ttgacgtgca taatccagat gttatgctta cagtcgagat tcgtgataag gtttacattt
    10561 attccagaga gattccggga ccgggtggaa tgccggttgg tacaaacgga agagcaatgc
    10621 ttcttctttc cggtggtatc gacagcccgg tagctggtta catgatttcc aagcggggtg
    10681 taagtattga cgcaacttac ttccatgcac ctccttatac aagtgagaga gcgaaacaga
    10741 aagtagtaga tcttgcaaaa gagattgcaa aatatacagg tcctatcaca ttacatgttg
    10801 taaactttac agatattcag atggcaattt atgagaaatg tcctcatgat gaattgacaa
    10861 tcattatgcg tcgttacatg atgaagattg cagaacattt cgcaaatcag gataactgtc
    10921 tttccctcgt tacaggtgag agtatcggac aggttgccag tcagacgatg cacagtctgt
    10981 acgtaacgaa tgaagtctgt cagatgccgg tattccgtcc ttgtatcgga cttgataaga
    11041 atgaaatcgt aaaagttgca gaaaagattg gaacatatga gacatctatt ttaccatacg
    11101 aagactgctg tactattttt gtggcaaaac atccggtaac aaagccaaga ttagatgtaa
    11161 ttaagcgttc tgagagaaat cttgatgatt gtattgacga gctgatgaag acagcgattg
    11221 aaacaacaga agaaattaag attaacgctc actaaagtat taatggatga aagcattttc
    11281 aaggcagaca taagtatttt gataatgttt ataatgcttg cagataagtg cctttttaaa
    11341 aggtgggaag aagaaatatc actaaaaata tttgttttat ctgaagattc atataagaaa
    11401 aatttatctg taaagaaaga accgaggaaa gtaatatttc ctcggttgat ttcataaata
    11461 catcacaggt tatatataat atatccgtat accagaaaac ccgctcttat gtaattattc
    11521 agttactaag tatggctgta actgttccat aatctcatca agattatcag cgttatggat
    11581 atttaaatcg ataggtttag aaatatctaa actgaaaatt cccatgatag actttgcatc
    11641 aataacgtaa cgaccggaaa ctaaatcgaa ttctgcatcg aaacgattga tgacattaac
    11701 aaatgttttt accttatcga tggaatttaa agagatttta atcgttttca tatacgcgct
    11761 cctcctaaaa atgtctatat atattttaat aatatagtac ctttttagtg aaaaaaagtc
    11821 aatagatttg aggaagattt ggaaaatatt atctaaagat aaaggggaat tttttggcat
    11881 gaatctggag atgaatgagg ttagaaaaaa taggattgca ggtaggaaat aataaataac
    11941 agaaaaaacg aaaaggagaa acggaaaaag gagatttgtt tttatgagta aaagaagagc
    12001 ggcgttcctt acactgggct gtaaagtaaa tcagtatgag actgatgcca tggaggagat
    12061 tcttgaaaag gcaggatacg agattgtcag ttttaaagag acagcggatg tctatattat
    12121 aaatacctgt tctgtaacaa atatggcaga cagaaagagc cgtcagatga ttcatcgtgc
    12181 aaagaaaaac aatccggatg caattatcgt ggcagcgggg tgttatgtgc aggcagcaga
    12241 ggaagaactg gcaaagaaaa atgaggcgga tattcttgtc ggtaataata aaaagaaaga
    12301 tatcgcccag atccttgagg aatattttgc ggcaaaagaa ccagagcagg aggtaccagt
    12361 tgtctcagaa gtaattgata ttaatcacac aaaagaatat gaagatttaa taattcataa
    12421 ggtaaacgag catacaagag catatattaa aatacaggat ggttgtaatc agttctgttc
    12481 gtattgtatc attccttaca caagaggaag aatccgcagt aaaaatccag aggaagtcat
    12541 tgaagaagta aaaaatctgg cagcacaggg ttataaagaa atcgtgctta ccggaattca
    12601 tttaagttcc tatgggaaag atttaggaac agtgaatctt cttgatgtga ttaagagaat
    12661 acagcagata gaggatgtgg agagaatccg tcttggttct ttagagccta gaattatcac
    12721 agaggagttt gtaaaagaac ttgtgaaatg tgataaagta tgtccacatt ttcatctttc
    12781 tttacagagc ggctgtgacc agacattaaa gcgtatgaac cgcaaatata caacagaaga
    12841 atatgaggaa gcattaaata ttttaagaaa gtactatgag catccggcat taacaactga
    12901 tgttattgca ggttttgttg gagaaactga ggaagaattt gaaaaaacaa gagcatatct
    12961 tgagaaaatc aatctatatg agatgcatat ttttaagtat tctgtacgag aaggaacaag
    13021 agcacagaag atgtccgggc atgtgccgga acaggtaaag acagaacgtt ccgaggtgct
    13081 tctttcgatg gcaaaaaggc acaagacagc atttgaagaa tggtatgttg gaagaaaaga
    13141 aaaagtactt ttagaagaaa ttgtagagaa aaatggtaaa aaatattttc agggatatac
    13201 ggctcattat gtgaaagttg cagtggaatt aacggaaaat gatacaaaat tagaacaaaa
    13261 tgaggtaatt gtagtagata ttcagggatt tattgatgaa aatttactgt acggaaaagt
    13321 ttcgattgaa ttttaatgtc actcatagta aaatatttat tgattgtaaa tctgctagaa
    13381 ggaggtagac atgggtagaa ataatacaca gttttttcat gtggttaaag aacaggaata
    13441 tgatgtagca tctattttga aagatgtata cgaagcatta acggaaaaag gatataatcc
    13501 agtgaatcag atcgtgggtt atattatgtc cggagatccg acttatatta ccagtcataa
    13561 gaatgcgaga agcttaatta tgaaggtaga acgtgacgag attcttgaag ttttatttga
    13621 aaattatatt gatactcagt taaagtaatt atgaaagaaa gatggatggg tcttgattac
    13681 gggacaaaga cagtaggtgt ggcggtaagt gatgttttgg gcattacggc acagggagtt
    13741 gagacagtta ccagaaagtc gaataagaag ctgcgccaga cattggcaag gatagaagcg
    13801 ctcatagaag aatatgaagt gagtaaggta gtactcggat tgccaaagaa tatgaataat
    13861 acgctgggag aaagagctga ggagacgaag gagtttcagg cgatgcttca gcgcagaacc
    13921 ggattggaag tagtcttatg ggatgaaaga ctgactacga tggaatcaga gagaattttg
    13981 caggaaggcg gagtgcgccg tgagaacagg aaagaacgca ttgactggat ggcggccact
    14041 ctgattctgc aaagttacat ggatgcacat ccaattccgg aaaagtaagc ggagaacgga
    14101 cgtaagtacg gaagaaagag gttttatatg aacaattatc agagtattcc atttaaagac
    14161 gaagatggaa aagaaaagga gttctatgtc ctcgaacaga caactctgaa tggatttcac
    14221 tatctgttag tagaagacgg aagtgcagat gcagatgacg aggaggttga agttcttatc
    14281 atgaaaagag ttgctgatgc ggctgaggat gaagaatggg caacctatga gatggttgaa
    14341 gacgaggaag aacttatatc agtatccaaa gtatttgagc agttaatgga cgatattaat
    14401 tttgaagtag aatagcagg
//
