LOCUS       c00041_gnlPro..        13437 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MKPGMPNI_41.
ACCESSION   c00041_gnlPro..
VERSION     c00041_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 00:12:07
            Original ID  :: gnl|Prokka|MKPGMPNI_41
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13437
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13437
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3437]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..3437
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13437
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13437
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             3..671
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_1"
                     /sec_met_domain="SucD_FumR (E-value: 5.1e-121, bitscore:
                     392.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GRKVVMSVTGIALVLFLTFHMAMNLVAIISAEGYNLVCEFLGANW
                     YALVATLGLAALFVIHIIYAFWLTIQNRAARGSERYAVVDKPKTVEWASQNMLVLGIIV
                     ILGLGLHLFNFWAKMQLPELVHNMGGVADTTYAADGVYHIMNTFSNPVYVVLYLVWLGA
                     LWFHLTHGFWSSMQSLGWNNKIWINRWKCISNIYSTIVVVCFALVVVVFFVKSLACGAC
                     "
     CDS             709..2652
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 197.1; E-value:
                     1.8e-60)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_2"
                     /sec_met_domain="FAD_binding_2 (E-value: 9.1e-61, bitscore:
                     197.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 4.9e-38,
                     bitscore: 121.1, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKIDSKIPEGQLAEKWSNYKAHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLGEMGFRVFNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNAIIDQCVAQGVPFARDYGGTLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQVQKGTVKLYTRYEMLDLVVIEGRARGIIARNLVTGEIERFAAHA
                     VVIGTGGYGNAFFLSTNAMGSNGSVAIQCYKKGAYFANPCFAQIHPTCIPVHGDKQSKL
                     TLMSESLRNDGRIWVPKKIEDAKALQAGTKKPTEIPDEDRDFYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNNTGLAVFLDFKYAIDRLGEDVVRARYGNLFDMYEEITDENPYK
                     TPMMIFPAIHYTMGGIWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLADQIQVPRFSTDLPEFAAAEKEVKDKIQKIKAVNGKHSVDSIHKKLGHI
                     MWDFVGMARTKESLQKALTGIEEVKKDFWTNVRIPGDVNELNVELEKALRLIDFIEVGM
                     LMARDGLNREESCGGHFRTEYQTPEGEALRDDKNFSYVACWKYTGENSEPELIKEDLNY
                     QFVKVQTRNYKS"
     CDS             2682..3437
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_3"
                     /sec_met_domain="Fer4_7 (E-value: 3e-12, bitscore: 38.1,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 4e-26, bitscore: 82.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.2e-06, bitscore: 20.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQKGPKAKGAFETYQMKDIPGDTSFLEMLDILN
                     EQIINDGGEPIVFDHDCREGICGMCSLYINGHPHGPATGATTCQMYMRRFKDGDTITVE
                     PWRSAGFPVIRDLMVDRSAYDKIMQAGGYVSVNTGAPQDANAILISKDIADEAMDAAAC
                     IGCGACVAACKNGSAMLFVSAKVSQLNLLPQGKVEAARRAKAMLSKMDELGFGNCTNTR
                     ACEAECPKNISISNIARLNRDFIIAKLKD"
     CDS             complement(3620..4465)
                     /locus_tag="ctg41_4"
                     /transl_table=11
                     /translation="MPSSVCGDPMMCQNCKKSVPNAIFHVYHRRGFHYPAQKCEENFIL
                     FLIKGEMLVNSREYAGTMLKAGEFMLQPISSKIEMLAMTDVECIYYQFNQPELFCDIRY
                     NRIMKETDPPLIPSPLPIIPELQHFLESARTYLSEKKICRDLLSLKRKELAFILGYFYS
                     DYDLASLVHPLSKYTSSFECFVYQNYKKVKTVEEFAKLGGYSQTTFRRIFDHVFHEPVY
                     EWMLSRRKEEIIYELQNTEATISEICYKFGFESLPHFSNFCKKSFGTSPRSIRLKRSSE
                     "
     CDS             complement(4596..5609)
                     /locus_tag="ctg41_5"
                     /transl_table=11
                     /translation="MKKILFAAVAALAITGCSQNEEIEKAAKTAEIGFNAIVKNTTRAA
                     VTNMGNLGNFKVHSYITGTAFDGTTAELGTAYMNGVLFETIDNTTWTKATSDTKTYYWP
                     SDASKSVQFFAYPSTLISDFSIPAAGTPGYPSFNYKVEDAAASQKDLVVAYESNKTATS
                     EGVNTGKLTLNFKHILSRINFAYIPGNTNLTYTVTAVKIADIKGGTAKYTFSASNGAWD
                     VTSGTSKEYTYTVTQSSNVVENKNYYMLGGEDASLMLFPQDVAKKVITVTYTSKDGDGV
                     QVFSGDKTVTLPDNSEWEVGKNILYILTLPAGGTEMTVTPKVSEWNTAEDKDQTAQ"
     CDS             complement(5661..6584)
                     /locus_tag="ctg41_6"
                     /transl_table=11
                     /translation="LLCMVLLSFLVVAGCGRRDILDDYPVSGVEVRLDWNGVTEKLPEG
                     VRIIFYPKGDNGRKVDTYLPVKGGHVGVPPGIYSVVVYNYDTETVLVRGDESYETIETY
                     TGLCNFGIAGTEKMVWGPEDFYTTCVDELMVEKSDESLILKLSPKLVVKTYHFSIKVTG
                     IKNISQVFGSVVGMADHYLLGKSFSLCDGCPIYFDVVRGKDTIEGSFTTFGISQIVRTR
                     AENTEVSLNLLLLKVDDTVQEVKVDVTEVIHKSEAGGETDKPEIDVPIEDEIKVDDVET
                     PPDGNGGMNGDVDDWEDETDIVIPVE"
     CDS             complement(6609..7511)
                     /locus_tag="ctg41_7"
                     /transl_table=11
                     /translation="MVAMPDAWTRMMIGVNQKDWSLLRERVQADLHVPDREDVLMLIDY
                     HRDDRMKCENLLRRLNGGEAYRYIMNKILPLLYVYREHSPVPIPDDKAAGVFLSTANVL
                     PRVKFVHPQPVVPEEGKIETPVIIEQRTVLALKNNLLYDLALAPNIEVEIPLNRRWSVN
                     AEYKCPWWLNSSREFCYQLLSGGVEGRCWLGNRKRRNRLTGHFIGAYAEGGIYDFQFKG
                     DGYQGRYYAASGLTYGYAKQIARHLSFEFSLGIGYLTTEYKKYTPYEGDLVWKSSARYN
                     FIGPTKAKVSLVWLITTRR"
     CDS             complement(8179..9300)
                     /locus_tag="ctg41_8"
                     /transl_table=11
                     /translation="MSTDEERIYSIALTQIPGVGHIGAKRLVDGMGSATDVFRYRTELP
                     DRLPGVNRAVVAALDSPQALKRAEQEYEFARNNRISCFTLADEDYPSRLRECDDAPVVL
                     FFKGKANLNALHIINMVGTRNATDYGKHICVSFLQELQMLCPDVLVVSGLAYGIDINAH
                     RSALSVELPTVGVLAHGLDRIYPSLHRKTAIDMLRQGGLLTEFLSGTNPDKHNFISRNR
                     IVAGISDATIVVESAAKGGSLITADIAGSYHRDCFAFPGRVTDEYSKGCNQLIQDNKAV
                     LLESASDFVKAMGWDSDLKSVKPETVQRNLFPDLSAEELRIVDILGKLGDLQINALMVQ
                     ADIPINKISAILFELEMKGVIRVLAGGVYQLLR"
     CDS             complement(9297..9710)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_9"
                     /sec_met_domain="HBT (E-value: 8.3e-12, bitscore: 36.5,
                     seeds: 132, tool: rule-based-clusters)"
                     /sec_met_domain="HBT_2 (E-value: 1.8e-10, bitscore: 32.5,
                     seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNKMEKYIYELTLKVRDYECDLQGIVNNANYQHYLEHTRHEFLSS
                     VGVSFAKLHEEGVDPVVARINMAFKTPLKSGDEFVSKLYMKKEGIKYVFYQDIFRKSDD
                     KVVVKSTVETVCVVNGRLSDSELFDQIFAPYLQ"
     CDS             complement(9703..10944)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_U32"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_10"
                     /sec_met_domain="Peptidase_U32 (E-value: 5e-71, bitscore:
                     229.5, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPVGSRESLAAAIQAGADSIYFGIENLNMRARSANTFTIEDLRE
                     IARTCDEHGMKSYLTVNTIIYDKDIELMRTIVDAAKEAGISAVIAADVAVMSYANKIGQ
                     EVHLSTQLNISNAEALKFYAQFADVVVLARELNLEQVAEIYWQIQEEHICGPSGELIRI
                     EMFCHGALCMAVSGKCYLSLHEMNHSANRGACMQICRRAYTVRDKDTDVELEVDNQYIM
                     SPKDLKTIHFMNKMIDAGVRVFKIEGRARGPEYVRTVVECYKQAIRAYLDDSFTDEKIA
                     AWDERLKTVFNRGFWDGYYLGQRLGEWTKNYGSAATERKIYVGKGIKYFSNIGVAEFLV
                     EAAEVSVGDKLLITGPTTGAVFATLDEARVDLKPVETVKKGEHFSMKLDKIRPSDKLYK
                     LVSTEELKKFKGLE"
     CDS             complement(11006..11500)
                     /locus_tag="ctg41_11"
                     /transl_table=11
                     /translation="LHLIHLFNWIEIMKKRLFSIALCLTFILSATSVSAQDAAYREALS
                     KMLEASGAMTTVKSMVPQMIGMMKHTYSNVPDEFWKSFEEQLSEKANTQFLDIYVSIYH
                     RYLTISDLKKITAFYESPVGKKLAESTPVMTAEAMEAGQQIGMGIAKEIMANLKEKGYV
                     Q"
     CDS             11559..12533
                     /locus_tag="ctg41_12"
                     /transl_table=11
                     /translation="MKIGHIDLGERPVFLAPMEDVTDPAFRLMCKKFGADMVYTEFVSS
                     DALIRSVNKTTQKLTICDEERPVAIQIYGKDTEAMVGAARIVEEAQPDILDINFGCPVK
                     KVAGKGAGAGMLQNIPKMLEITRAVVDAVKIPVTVKTRLGWDADHKIIVDLAEQLQDCG
                     IAALAIHGRTRAQMYTGEADWTLIGEVKNNPRMHIPIIGNGDVTTAAGAKECFERYGVD
                     AIMIGRGSIGRPWIFREVKHYLETGEELPRESFEWYLDVLREEVLNSVARLDERRGIIH
                     IRRHLAATPLFKGIPNFRETRIAMLRTESVEELFRIFDGLTTE"
     CDS             12657..12950
                     /locus_tag="ctg41_13"
                     /transl_table=11
                     /translation="VLLCGKSTPSLEHRHCEPLLEHLRHQYIQHESRNKSCDRINQIVC
                     LNVNSSSTKQQIERHQAGKQFLAGTPCHNHQNGRHAHMRTGKSGSRTFSYLL"
     CDS             12978..13400
                     /locus_tag="ctg41_14"
                     /transl_table=11
                     /translation="MLITGTGKQLLIVIEIIANGRKDALRNRIHADGREIELRAGNRNE
                     YINKVVDEKAGDQYKRHLLKQVEPIDEIEQRHNQNHRIISEIAHVERLAHPHLRKRMTE
                     PYGRLSAEHPLLGRSKQMIQIGEDAVELESIRIPVG"
ORIGIN
        1 taggaaggaa agtggtgatg agcgttaccg gtatcgccct tgtcctgttt ctaacgtttc
       61 acatggcgat gaaccttgtt gcgatcatct cggctgaggg ttacaacttg gtttgtgagt
      121 tcctgggagc aaactggtat gcgttggtag ctacgctggg cctggctgcc ctcttcgtga
      181 ttcacattat ctacgctttc tggctgacaa tacagaatcg cgcagcacgt ggtagcgaac
      241 gttacgccgt agttgacaaa cctaaaaccg tggaatgggc atcacaaaac atgctggtgc
      301 tgggtatcat cgttatctta ggtttgggcc ttcacctctt taacttctgg gctaaaatgc
      361 agttacctga attggtgcac aacatgggag gagtagcaga cacaacttat gctgctgatg
      421 gtgtttatca catcatgaac actttctcta accctgtata tgtagtgctg tacctcgttt
      481 ggctgggcgc cctttggttc cacctgactc atggtttctg gagctctatg caatctttgg
      541 gctggaacaa caagatttgg atcaaccgct ggaaatgcat ctccaacatc tattcaacca
      601 tcgttgttgt atgctttgct ctggtagtag tcgtattctt cgttaaatcg ttggcatgcg
      661 gtgcttgcta aattgtaaat tgtaaatgat taaattgtaa atagcattat gactaagata
      721 gattcaaaaa ttcctgaagg ccagctcgcc gaaaaatgga gtaactataa ggctcatcaa
      781 aaacttgtta accctgccaa caaacgtcgc cttgacatta tcgttgtagg taccggactt
      841 gccggagcat ctgctgccgc ttctttgggc gaaatgggtt tcagagtatt caatttctgt
      901 attcaggatt caccccgccg tgctcactct attgcagcac agggtggtat caacgcagct
      961 aaaaactatc aaaatgatgg tgactcggtt taccgtcttt tctacgatac aatcaaaggc
     1021 ggtgactacc gtgcacgcga agccaacgtt taccgtctgg ctgaggtatc aaacgctatc
     1081 atcgaccaat gcgtagcaca gggtgtacct ttcgcacgcg attacggtgg cacacttgac
     1141 aaccgttcat tcggtggtgc acaggtatcc cgtacgttct atgcccgcgg ccagaccgga
     1201 cagcagctgt tgctgggcgc ttattcagca ttgagccgtc aggtacaaaa aggtactgtt
     1261 aaactttaca ctcgttacga aatgctcgac ctcgttgtaa ttgaaggacg tgcgcgcggt
     1321 atcattgccc gtaacctcgt aaccggtgaa atcgaacgtt tcgctgctca cgctgtagtt
     1381 atcggtacag gtggttacgg aaacgcattc ttcctttcta ccaacgctat gggttccaac
     1441 ggttcagttg ccatccagtg ctataagaaa ggtgcttatt ttgccaatcc ttgtttcgct
     1501 cagattcacc cgacttgtat ccccgtacac ggtgacaaac agtctaagct gacattgatg
     1561 tctgaatcac ttcgtaacga cggtcgcatc tgggttccga agaagattga agatgccaaa
     1621 gcattgcagg caggcactaa aaagccgacc gaaattcctg atgaagaccg tgacttctat
     1681 ctggaacgcc gttacccggc attcggtaac cttgttccgc gtgacgttgc ttcacgtgca
     1741 gccaaagaac gttgtgatgc cggtttcggt gtgaacaata ccggtttggc cgtcttcctc
     1801 gatttcaaat atgctatcga tcgtctgggt gaggacgtgg ttcgtgcccg ttatggtaac
     1861 ctcttcgaca tgtacgaaga aatcactgac gagaacccgt acaagactcc gatgatgata
     1921 ttccccgcta tccactacac catgggtggt atctgggttg attatgaatt gatgacttct
     1981 atcccgggtc tgttcgctat cggtgaagcc aacttctccg accacggtgc taaccgcttg
     2041 ggtgcatctg cattgatgca gggtctggct gacggatact tcgtattgcc ttacactatc
     2101 cagaactacc tggccgatca gattcaggtt ccgcgcttct ctaccgacct gccggaattt
     2161 gctgcagccg aaaaggaagt gaaagataag atccagaaga tcaaagccgt aaacggaaaa
     2221 cactctgttg actctatcca caagaaactg ggtcacatca tgtgggactt cgtaggtatg
     2281 gcccgtacaa aagaatctct gcagaaagcc ctgacaggca ttgaagaggt gaagaaagat
     2341 ttctggacca acgttcgcat cccgggtgat gtaaacgaac tgaacgtaga actggaaaaa
     2401 gcacttcgtc tgattgactt cattgaagta ggtatgttga tggctcgcga cggtttgaac
     2461 cgtgaagaat cttgcggtgg acacttccgt accgaatacc agaccccgga aggtgaagcg
     2521 ttacgtgacg ataagaactt ctcatacgta gcttgctgga aatacaccgg tgaaaattca
     2581 gaaccggagt tgatcaaaga agatttgaac taccagttcg taaaagttca gactcgtaac
     2641 tacaagtcat aattcggcta atcaattaaa ggaaaacaaa aatggataaa aatatatcat
     2701 tcacactgaa ggtatggcgc cagaaaggcc cgaaagcaaa aggtgctttt gaaacatatc
     2761 aaatgaaaga tatcccgggc gatacgtcgt tcctcgaaat gctggatatc ctgaacgaac
     2821 agattattaa tgacggtggc gaacctatcg tattcgatca tgactgccgc gaaggtatct
     2881 gcggtatgtg ttctctttac atcaacggac acccgcacgg acctgcgaca ggtgctacta
     2941 cctgccagat gtatatgcgt cgcttcaaag atggagacac catcacagtt gaaccttggc
     3001 gttctgccgg tttcccggta atccgtgact tgatggttga ccgttcggct tatgacaaga
     3061 tcatgcaggc cggtggttac gtaagcgtaa acacaggtgc tcctcaggat gccaacgcta
     3121 tccttatctc taaggatatc gccgacgagg ctatggatgc cgctgcatgt atcggttgcg
     3181 gtgcttgtgt agctgcttgt aagaatggtt ctgccatgtt gttcgtatca gctaaggtca
     3241 gccagctgaa cctccttcca caaggaaaag tagaagcagc acgccgtgca aaagctatgc
     3301 tttctaagat ggacgaactg ggattcggta actgtacaaa cacacgtgct tgtgaagcag
     3361 agtgtccgaa gaacatttca atcagcaaca tcgctcgttt gaaccgcgat ttcatcatcg
     3421 caaaactgaa agactaagca caacttagca tttgattaat aagtaggaaa gaggctgtcc
     3481 cactttttgg gacagcctct tttgtttatt tcgataagaa tcttatcgtg gcaaaaaaat
     3541 ctgcggtagt gccgaataca gcatttaaaa gaatcaaaat ccaactaagt ttgtcgaaaa
     3601 aagatccaag tttatcatct cattcggatg aacgcttcaa tcgaatgctg cgtggcgagg
     3661 taccaaatga ctttttacag aagtttgaga aatgcggtaa agattcgaac ccgaatttat
     3721 aacagatttc agagatggta gcctctgtat tctgaagttc gtaaatgatc tcctctttgc
     3781 ggcgactaag catccactca tacaccggct catgaaaaac atgatcgaaa atcctcctga
     3841 atgtagtctg actatatcct ccaagtttag caaactcttc aacagtcttc accttcttat
     3901 agttctgata tacaaagcac tcaaacgaag aggtatattt tgagagagga tgtaccaggg
     3961 aagccaggtc ataatccgaa taaaaataac cgagtatgaa agcaagctct ttccgcttta
     4021 atgataagag atcccgacaa atcttctttt cgctcagata agtacgtgca gactcaagaa
     4081 aatgttgaag ttcgggaata atgggtaagg gtgagggaat taacggagga tcagtctcct
     4141 tcatgatacg attataccgg atatcacaaa acaattcagg ttgattaaac tgataataga
     4201 tacattccac atcggtcatg gccagcattt ctattttcga actgatgggc tgaagcataa
     4261 attctccggc cttaagcatc gttccggcat actcccggct attcaccagc atttctccct
     4321 tgataaggaa caaaatgaaa ttctcctcac atttttgtgc aggataatgg aaaccacgtc
     4381 tatggtaaac atggaaaatg gcattaggaa ctgacttttt gcagttctga cacatcatgg
     4441 gatctccaca aacggagctg ggcatatata cgggtgtgtt tgtttgtatg tttgcgacaa
     4501 atgtaagaga attatttaga aagacaataa aagaaggaat aaaaaaatag ccctgcgaaa
     4561 aggcagggct atcaattaca tctcttggta tatggttatt gggcagtttg atctttgtct
     4621 tctgctgtat tccattcact aaccttcgga gtaaccgtca tctcggtacc tcctgcaggc
     4681 aaggtcaaaa tatagagtat attcttacct acctcccatt cggaattgtc aggaagtgtc
     4741 actgttttgt caccactgaa tacctgaact ccatcaccat ctttacttgt gtaagtcaca
     4801 gtaattactt tttttgctac atcctgagga aacaacataa gagatgcgtc ttcgccaccc
     4861 agcatatagt aatttttatt ttccacaaca tttgaagact gtgtaacggt ataagtgtat
     4921 tctttagagg ttccacttgt aacatcccat gctccgtttg atgcgctaaa agtatattta
     4981 gctgtacctc cttttatatc ggcaatcttc acggcagtta ctgtatatgt cagatttgta
     5041 tttcccggga tatacgcaaa attaattcgg gataatatat gtttaaaatt caaagtcagc
     5101 ttacctgtat taacaccttc cgaagtggcc gttttattac tttcgtatgc gactaccaag
     5161 tctttctgac tagcggctgc atcctcaacc ttataattaa acgaaggata tcccggagtg
     5221 ccggcagcgg gaatgctaaa atcgctaatc agcgtagaag gatacgcaaa gaactgcact
     5281 gatttactcg catccgaagg ccaataataa gttttagtat cagaagtggc ttttgtccaa
     5341 gttgtattat ctattgtttc aaacaaaaca ccattcatat aagcagtacc caattcagcg
     5401 gtagtaccgt caaaagcagt tccggtaata taagagtgca ctttaaaatt acctaaattc
     5461 cccatattgg taaccgccgc tcttgtggta ttcttcacaa tcgcattgaa cccgatctcc
     5521 gcagttttcg ccgccttctc aatctcctca ttctgtgagc aacctgtgat tgccaatgca
     5581 gcaactgccg caaataaaat ctttttcata atagtatgtt ttataaatta ataattatct
     5641 cttttatctg cctaccggtg tcattccacc ggtatcacta tatctgtttc atcctcccaa
     5701 tcatccacat ccccattcat accaccgtta ccatccggag gagtttccac atcatctact
     5761 tttatttcat cttcgatagg aacatcaatt tccggtttat cagtttctcc accagcctcc
     5821 gatttgtgta tcacttcggt tacatcaacc ttcacttcct gcactgtatc atccaccttc
     5881 agcagtagca aattcaaaga tacttccgta ttctcggcac gagtacgtac gatctgagag
     5941 attccaaaag tcgtaaaact tccctcaatt gtatcttttc ccctaactac atcaaaatag
     6001 atcggacagc cgtcacacaa actaaaactt ttgcctaaca aataatgatc ggccatcccc
     6061 actacactgc caaagacttg ggatatattt ttaatcccgg ttactttaat gctgaagtgg
     6121 taagttttca ctaccagctt cggagatagt ttcagtatca aagattcatc gcttttttcc
     6181 accatcaact cgtccacaca agtcgtataa aagtcctcag gcccccaaac catcttctct
     6241 gtaccggcaa ttccaaaatt acaaagaccg gtataagttt caatcgtctc gtatgactca
     6301 tcaccccgga ccaatacggt ttccgtatca taattgtaga ctaccacgga atagatacca
     6361 gggggaactc ctacatgccc tcctttcaca ggcagatagg tgtctacttt acgtccgttg
     6421 tcccctttcg gatagaaaat aatccgaact ccttccggca acttctccgt cactccgttc
     6481 caatccagcc gcacttccac accactcacc ggataatcgt ccagaatatc ccgccggccg
     6541 catcccgcta ccaccagaaa cgagaggaga accatgcaaa gcaaccttgt tatatctttc
     6601 attcattatc atctccttgt tgttataagc cacaccaaag atacttttgc cttggtaggg
     6661 cctatgaagt tatagcgtgc actacttttc caaaccaagt ctccctcata aggagtgtac
     6721 ttcttgtact ccgtagtcag ataacctatg cccaggctga attcaaacga gagatgccgt
     6781 gcaatctgct ttgcatatcc ataagtcagc cctgaagctg cataatatct tccttgatag
     6841 ccgtctcctt taaactggaa atcataaatc cccccctcgg cataagctcc aatgaaatgt
     6901 cccgtcaagc ggttcctccg cttccggttg cccaaccagc aacgaccttc aacgcctccc
     6961 gaaagcaatt gatagcaaaa ctcccggcta ctattgagcc accacggaca tttatactcg
     7021 gcattgaccg accagcgtct gttcaatggt atttccacct ctatattcgg tgccaatgcc
     7081 aggtcgtata gcaggttgtt tttcagtgca agcactgttc tctgttctat tattactggt
     7141 gtttctattt ttccctcttc cgggaccacc ggctgaggat gtacgaattt cactcgaggc
     7201 aatacattcg ccgtactcaa aaacacaccg gcagctttat catccggtat gggtacaggt
     7261 gaatgttctc tgtatacata taaaagcggt aagattttat tcataatata gcggtatgct
     7321 tctccaccgt tcaacctgcg taataaattc tcacatttca tccggtcatc gcggtgataa
     7381 tcgatcaaca tcagcacatc ctcacgatcc ggaacgtgga ggtcagcctg cactctttcg
     7441 cgtaacagcg accaatcctt ctggtttaca ccaatcatca ttctggtcca ggcatccggc
     7501 attgctacca tggcccggct ttctcccgaa agcagaaaga gaaaaacaaa aagggtcagt
     7561 atgcagatac ggttttccat aatttgtctg tttgtgcaat acaaatatag aagttcaaat
     7621 cgatacataa taatttaatc aaagctaaat acaagctctg aatgcttctg tgaaacgatt
     7681 gaaaggaatt tgcaagtttg gcggtgaagc acccccgcac ttgggtagct ttccggccaa
     7741 tgccggcctc taaaagtgga tactgccgtt gcttaaatct tcttacttac cacctgactt
     7801 acttatctcg gcaagaaaat agatctgtct ctacgacata cgttgtccga catgggggtg
     7861 tcagacagtc tgacaccccc atgttaaacc tcccgacatc cccatgtcag actatgaaga
     7921 gtgggaacct aatgaagaaa gcttttcaag gaaagtgaag ggaggttaaa agcaaaagag
     7981 ttattgccga tgtttagccc acttgtaaaa gagaacagta aaaaacagta aaagaaactc
     8041 aaagagagcc aatattaaga agaatatttg gagaatagat aagagaaacc tacatttgta
     8101 cagtgatttt tttcatagta ttagatttaa ggttaacaaa aggttggagt caggcgtgac
     8161 tccttttttt tgcctttttt atctgagtaa ctggtaaact cctcctgcca gaacccgaat
     8221 aacgcctttc atttcaagtt caaacagaat agcactgatc ttattaatgg gaatatcggc
     8281 ctgaaccatc aatgcgttta tttgcagatc gcccagcttt ccgagaatat cgacaattct
     8341 cagttcctcg gcagacagat ccggaaagag gtttcgctgt acggtttccg gcttgacact
     8401 tttcaaatcg ctgtcccagc ccattgcttt cacaaagtcc gatgcagact ccagcaaaac
     8461 agctttgtta tcttgtatca actggttgca tccctttgaa tattcgtccg tgacccgccc
     8521 gggaaaagca aaacaatcgc gatgatagct tccggcaata tccgctgtaa tcagcgaacc
     8581 gcctttagcg gcagactcca ccacaatagt agcatcactt ataccggcaa caatgcgatt
     8641 ccgacttatg aagttgtgtt tatccggatt cgttccggaa agaaattctg tcagcaatcc
     8701 gccttgccga agcatgtcga tagctgtctt acggtgaagg gacggataga tgcgatccag
     8761 cccgtgagcc aataccccca cagtaggaag ttcgacagac agtgctgagc ggtgggcatt
     8821 gatatcgatt ccataagcca atccactgac tacaagcaca tccggacaca gcatctgcaa
     8881 ctcttgcagg aagctgacac aaatgtgctt cccgtagtct gtcgcattac gggtccccac
     8941 catattaata atgtgtaagg cattgagatt ggccttccct ttaaagaaca gcacgacagg
     9001 agcatcgtca cactcccgta agcgggaagg ataatcttca tctgccagtg taaaacaaga
     9061 gatgcggtta ttccgggcaa actcatattc ttgctcggca cgcttcaagg cctgtggaga
     9121 gtctaatgcc gcgactaccg cccgattcac tccgggcaaa cggtcgggca gctcggtacg
     9181 gtagcgaaat acatcggtag cacttcccat accgtctacc aggcgcttgg cacctatatg
     9241 ccccacaccc ggtatttgtg tcagagcaat gctgtatatc cgctcttcat ccgtactcat
     9301 tgcagatagg gtgcgaagat ctgatcgaat aactcactgt cgctcaagcg tccattaacg
     9361 acacatacgg tctctacggt cgacttaacg actactttat catcgctttt ccgaaagata
     9421 tcctgataga atacatattt gatgccttct ttcttcatat acaatttgga aacgaattca
     9481 tcgccactct tcaacggggt tttgaaagcc atattgatgc gggctaccac cggatcgact
     9541 ccctcttcat gcagttttgc aaagcttacg cctaccgatg aaagaaactc gtgacgggta
     9601 tgctccagat aatgttggta attcgcatta ttcacaatgc cttgcaggtc gcactcatag
     9661 tcgcgtacct ttaaagtaag ttcatagata tacttttcca ttttattcaa gccctttaaa
     9721 ttttttcagt tcttcggtcg aaaccaattt atataactta tcactcggac gtatcttatc
     9781 cagtttcatt gagaagtgtt ctcccttttt cacagtctcc accggtttca gatctacacg
     9841 agcttcgtca agcgtagcaa acacagctcc ggtagtaggt ccggtgatca acagtttatc
     9901 acccacactt acttctgccg cttcaaccaa gaattcggcc acaccaatgt tagagaaata
     9961 tttgatgcct ttacccacat atatcttacg ctcagtggct gccgacccgt agttcttggt
    10021 ccattcgccc aaacgctgtc ccaagtaata gccatcccag aatccccggt tgaatacagt
    10081 cttcaggcgt tcatcccatg ccgcaatctt ctcgtcggta aacgaatcat ccagatatgc
    10141 ccggatggcc tgcttataac attcgacgac agtacgtacg tattcgggac cgcgggctcg
    10201 accctcaatc ttgaacacac gtaccccggc atctatcatt ttgttcatga agtgaatggt
    10261 cttcaagtct ttcggcgaca tgatatactg attgtcaacc tcaagctcta catcggtatc
    10321 tttgtcacgg acggtgtaag cacggcgaca gatttgcatg caagctcccc ggttggccga
    10381 atgattcatc tcgtgcaatg acagatagca tttacccgaa acagccatgc aaagcgcacc
    10441 gtggcagaac atctcgatac gaatgagctc accactcgga ccgcagatat gctcttcctg
    10501 aatctgccag tagatctccg ccacctgctc cagattcagt tcacgagcca acaccactac
    10561 atcggcaaat tgcgcataga acttcagggc ttccgcattc gaaatattca attgagtaga
    10621 cagatgtact tcctgcccaa tcttgttggc atagctcatc actgccacgt cagccgcaat
    10681 cacggccgaa atgcccgctt ccttggccgc atcgacaatg gtacgcatca attcgatatc
    10741 cttatcgtaa atgatggtat tcactgtcag ataactcttc attccatgtt catcacaggt
    10801 ccgggctatc tcgcgtaaat cttcgatggt aaatgtattg gccgaacgtg cacgcatgtt
    10861 caggttctca ataccaaaat aaatagaatc ggctcctgcc tggatagctg ccgcgagcga
    10921 ttcgcgtgag ccaaccggag ccattatttc aaaatcgttt atcttataca tagtcacaaa
    10981 ttataagtta cggagtcgta actacttact gaacatatcc tttttctttg aggtttgcca
    11041 ttatctcctt ggcaattccc ataccgatct gttggcccgc ttccatggct tccgcagtca
    11101 tcacaggagt ggactcggcc agcttcttgc ctaccggcga ttcataaaat gcagtgatct
    11161 tcttcaggtc gcttatcgtc aggtatctgt gatagataga cacgtatata tccagaaact
    11221 gggtgtttgc tttctccgat aattgctcct cgaagctctt ccagaattca tccggaacat
    11281 tcgaataagt atgtttcatc atcccgatca tttgcggaac catcgacttc actgtagtca
    11341 tggcacccga agcctcaagc atcttgctta atgcctctct gtaggcagca tcctgggccg
    11401 agacggaagt ggcagacaag ataaaagtca ggcacagagc aatggaaaat agtctttttt
    11461 tcataatttc tatccagtta aataaatgaa tgaggtgcaa aggtaggggt tttttccgta
    11521 cttttgcagc caaataatga atagaaaatc gtaaaaagat gaaaataggc cacatagacc
    11581 tgggcgaacg ccctgtattt ctggctccga tggaggatgt cactgacccc gcttttcgcc
    11641 tgatgtgcaa aaagtttgga gccgatatgg tatacaccga gttcgtctcg agtgatgctt
    11701 tgatacgttc cgtcaataaa accactcaaa aactgaccat ctgcgatgaa gaacgccccg
    11761 tcgccattca aatatacggt aaagacacgg aagccatggt gggtgccgcc cggattgtag
    11821 aagaagcaca accggatata ttggatatca actttggttg cccggtaaag aaagtagcag
    11881 ggaaaggggc cggagccggc atgttgcaga atatccccaa gatgctggaa ataacccgtg
    11941 ccgtggtaga tgcagtcaaa atacctgtca ccgtgaaaac ccgactggga tgggatgccg
    12001 atcataaaat aatagtggac ctggcagagc aactgcagga ttgcggcatt gcggcactgg
    12061 ccattcacgg acgtacccgt gcgcagatgt atacaggcga ggcagactgg actctgatag
    12121 gagaagtcaa gaataaccca cgtatgcaca tacctattat aggaaacggc gatgtgacta
    12181 cggccgctgg tgccaaagag tgctttgagc gatatggtgt agatgcgatt atgataggac
    12241 gcggcagtat cggccggccc tggatattcc gcgaagtgaa gcactatctg gaaaccggag
    12301 aagaacttcc gcgggaatca ttcgagtggt acctcgatgt gttgcgcgaa gaggtgctga
    12361 acagtgtagc ccgactggac gaacgcaggg ggatcatcca tatccgccgt catctggcag
    12421 caactcccct atttaaagga atccccaatt tccgtgagac acgcattgcc atgctacgca
    12481 ccgaatcggt agaagaactc ttccggatat tcgacggact caccacagag taacacggag
    12541 ttccacagag tagagtggac aaatcgatag ttgatatgag agttaatgta gatttatttt
    12601 agtatatgtg tacgaacttt attttaataa aatttattta ttctctgtga gactctgtgt
    12661 tactctgtgg taagtccacc ccatcacttg aacatcggca ctgcgaacca cttcttgaac
    12721 atcttcgtca ccaatacata caacacgaaa gcagaaacaa atcctgcgat cgcatcaatc
    12781 agatagtgtg cctgaatgta aacagtagct ccacaaagca acagatagaa cggcatcagg
    12841 caggcaaaca gtttcttgct ggcacgccat gccataatca tcagaatggt cgacacgccc
    12901 acatgcgaac tgggaaaagc ggcagtcgga cgttctccta cttgctgtga accctccacc
    12961 aggctgtaaa agaatccatg ctgataaccg ggaccgggaa gcaactcctg attgtgattg
    13021 aaataatcgc caatggaagg aaagacgccc tgcgaaaccg aatccatgcc gatggcaggg
    13081 aaatagaact gagggccggc aaccggaacg aatatataaa taaggtagta gatgaaaaag
    13141 caggtgacca gtacaaaaga catcttctca aacaggtcga accgatagat gaaatagaac
    13201 aacgtcacaa ccagaatcat aggataataa gcgaaatagc ccatgttgaa cggctcgctc
    13261 acccacatct gcggaaacgc atgacagaac catacggcag gctgtccgcc gaacatccac
    13321 tgctcggccg tagcaaacaa atgatccaga ttggggaaga cgcggttgaa ctcgaaagta
    13381 tccggatacc agtaggataa aaggctcatc tggatggcga tacgtacaaa agcagaa
//
