LOCUS       c00064_gnlPro..        11761 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LAFCGIMH_64.
ACCESSION   c00064_gnlPro..
VERSION     c00064_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 00:34:14
            Original ID  :: gnl|Prokka|LAFCGIMH_64
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11761
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11761
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3478:8801]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3479..8801
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..11761
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11761
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(5..883)
                     /locus_tag="ctg64_1"
                     /transl_table=11
                     /translation="MAERITGHTELIGLMAYPIRHSSSPAMQNEAFAKLGYDYAYLAFE
                     VGADEIEDAVKAIRTLKMRGSNVSMPNKTLVGKYLDELSPAAELCGAVNTIVNDNGHLT
                     GHITDGIGFMSALKDNDIDVIGKKMTIVGAGGAATAIEIQAALDGVAEITIFNRKDEFW
                     DRAVSTVEKINTKTSCHAVLYDLADLDKLKAEMDDSYIFVNATGVGMKPLEGQSVVPDK
                     SYFRPELIVIDVPYSPLETKMRSMAKEVGCKTMNGLGMMLFQGSAAFELWTGEPMPIEH
                     MKEILHISYDD"
     CDS             complement(920..2872)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) baiH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg64_2"
                     /sec_met_domain="baiH (E-value: 3.5e-142, bitscore: 464.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIKNRIVMMPMGTNYGEQNGEMSFLHINYYKERAKGGTGLIIVE
                     NASVDSPQGSNGTTQLRIDHDNYLPRLYKFCEEIHKYGTCIAIQINHAGASAVSARTNM
                     QPVSASDVPSKEGGEIPRPLSVEEIHHIVKKYGEAAKRAQAAGFDAVEIHAGHSYLISQ
                     FLSPLTNKRTDEFGGSVENRTRFCRMVIEEVRKQVGPSFPIMLRLSADELMEGGNTLED
                     TLEYLEYVQDEVDIFDVSCGLNGSIQYQIDANYMKDGWRSYMPKAVREKFGKPCISMGN
                     IRNPKVAEQILADGDADLIGMGRGLIAEPAWVNKVATGRECDLRKCISCNIGCAGNRIG
                     FNRPIRCTVNPAVLEGDVYKNQKVNKNCNVVVIGGGTAGLEAACTAAEVGCNTFLLEKG
                     ETLGGLASVISKIPAKKRLADFPNYLIHRAEQLENLYIFTNTEGTPENIRKFHPNLIVS
                     STGSAPLLPPIRGLHDRIDKEGSKVASILGMINHINDYPEDMTGKKVVVVGGGAVGLDV
                     VEFFAARNAEISIVEMMDQIGRDLDPVTKNDMKDQMKKHHVAQLTKTALQEVKDSSFLV
                     KDAEGERELPFDYGFVCLGMRAQGQLFAELSDAFVSDDVEILNIGDSKRARRIIDGTLE
                     GRNILNTLTQMGYLQ"
     CDS             3479..4915
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_3"
                     /sec_met_domain="CT_Vparvula (E-value: 1.1e-136, bitscore:
                     445.7, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNATQSLAGTRITSLLDANSFVEIGQGVTARSTDFNMTANKAPS
                     DGVITGYGVIDDKLVYVYSQDASVLNGTVGEMHAKKITRLYDLAMKTGAPVIGLVDCAG
                     IRLQEATDALEAFGQIYLKQTLASGVIPQITAIFGTCGGGMAVIPSLTDFTFMESKKGK
                     MFVNTPNALEGNNTDKCDTAAADFQSKETGVIDGVGTEDEILGQIRSLVSLLPSNNEDT
                     DNYTECTDDLNRVCADLANCAGDTAIALSQIADNGEFFETKADYAKDMVTGFIRLNGAT
                     VGAVANRSEVYDAEGKKTETFDGSISARGARKAADFVKFCDAFDIPVLTLTNATGFMAT
                     LCSEKMMAKSVGELVAAFADATVPKVNVIIGKAYGTAYVAMNSKSIGADLVYAWDNAEI
                     GMMDASLAAKIMYADADAAELNEKAAQYRELQNGVASAAARGYVDTVISPADTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
     CDS             4963..5685
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_4"
                     /sec_met_domain="OAD_gamma (E-value: 6.3e-28, bitscore:
                     86.8, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFLVMAALVIGSTSVVFAADKVDDTVKSTLVTTAEGLTDAIVQL
                     KDEEIENYMSSGDDFTTSAMQSWQTSKDELGAKKDSNGETTVTFKDDQYTVTVPLKFEK
                     AEANFVYVFDSQGTPTSMSVDVQYGMGKTLQRAGLNTLMGIGTVFVMLILLSLLISLFR
                     FIPNPEAKKAAEAKAAKAAKEAEAAAIAQTAPAQAEENLADDGELVAVIAAAIAAAEGT
                     TTDGFVVRSIRKVKRNRR"
     CDS             5713..6081
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63; E-value:
                     6e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_5"
                     /sec_met_domain="Biotin_lipoyl (E-value: 9.7e-21, bitscore:
                     63.0, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGTAYEVTVEETGSVSAPAAAPKAAPKAAPAAAPKAA
                     APAAGAGAVKVTASVPGKVVKVAASVGQAVKAGDSVVILESMKMEIPVVAPQDGTIASI
                     DVAEGASVENGDTLATMN"
     CDS             6098..7246
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_6"
                     /sec_met_domain="OAD_beta (E-value: 4.2e-157, bitscore:
                     511.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVTETLSNLIHQTAFFSLTWGNYLMIAVACVFLYLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMANPEDMSNGVGGLLHYFYILDEWSILPSLIFMGVGAMTD
                     FGPLIANPISFLMGAAAQLGIYAAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLAGKL
                     GQSALMGPIAVAAYSYMSLVPIIQPPIMKLCTTEKERKIKMDQLRPVSKLEKILFPIVI
                     TIVVCLILPTTAPLVGMLMLGNLFRECGVVKQLTETASNALMYIVVILLGTSVGASTSA
                     EAFLNADTLKIVVLGLVAFAIGTFGGCMLGKLLCKLTHGKINPLIGSAGVSAVPMAARV
                     SQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             7389..8801
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_7"
                     /sec_met_domain="HMGL-like (E-value: 3.6e-47, bitscore:
                     150.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 4e-59, bitscore: 189.1,
                     seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELEKKPVKIVETILRDAHQSQIATRMTTEQMLPIVDKLDKVGY
                     HAVECWGGATFDASLRFLHEDPWERLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSAANGIDIIRIFDCLNDLRNLQTAVSAANKEKAHAQVALSYTLGDAYTLEYWTD
                     IAKRIEDMGADSICIKDMAGLLLPNKATELVTALKETVKIPIDLHTHYTSGVASMTYLK
                     AVEAGVDIIDTAMSPFALGTSQPATEVMVETFKDTPYDTGFDQKLLSEIADYFRPIRDE
                     ALDSGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYDVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKMVTKETKDILLGKYGATVKPFNPEVQKKCIGD
                     EKPITCRPADLLDNELEKLESEMAQYKEQDEDVLTYALFPQVAMDFFKYRQAQKTKVDE
                     KAADKKNGAYPV"
     CDS             8913..10373
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg64_8"
                     /sec_met_domain="HI0933_like (E-value: 6.5e-129, bitscore:
                     419.5, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPVVHIYIDRSEAETWNHDEIDNLQGKINTGEYSMSKVIIIGGG
                     AAGMMAGVFAARNHHEVHILEKNEKLGKKVFITGKGRCNVTNACDTEELFPAMMSNPKF
                     LYSSFYSFTPQDVMEFFEKAGVPLKVERGNRVFPQSDHSSDIIRALERELKKAGAKIHL
                     HTAVQEIVKKPVTESVTDSVNTLESEAALTESGSDAGKSRKGKKSSDIQQEKITGVILT
                     DGTFIEGDAVIVATGGFSYQSTGSTGDGYRFARELGLKVTDIAPSLVPLKTKEDYIPKL
                     QGLSLKNTGLTIKNGKKVLYEDFGEMMFTHFGVTGPMILSASAHIGAKLAKAPNGELSA
                     YLDLKPALTREQLDARILREFEAGPNKQFKNVIGVLFPSSLTPVMLELGGIPAEKKIHD
                     ISREERQHFIDLIKAFPFTITGMGEFKEAIITRGGVSVKEINPGTMESKKISGLYFAGE
                     VLDLDAVTGGYNLQIAWSTAYLAAQAIQ"
     CDS             10522..11193
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg64_9"
                     /sec_met_domain="Cytidylate_kin (E-value: 1.6e-78,
                     bitscore: 252.7, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGCNIAIDGPAGAGKSTIAKKVAKELSFIYVDTGAMYRAMALYLL
                     NHGVNGENQEEIEAVCSGADISIEYKNGEQIVILNGENVNAMIRTEQVGNMASKSSANP
                     KVRAHLLKLQRTLAEKNDVVMDGRDIGTTILPNAEVKIYLTASADTRAKRRALEYEQKG
                     EAFDLEQIRKDIIERDERDMNREVSPLKQAEDAVLVDSSEMGIDDVVNAILNVYKEKVQ
                     K"
     CDS             11212..11760
                     /locus_tag="ctg64_10"
                     /transl_table=11
                     /translation="MKVKVAETAGFCFGVKRAVNKVYELIDTEQKPIFTLGPIIHNEGV
                     VADLEARGVHVIAEADLDSPDDTLQNGTVVIRSHGVGKSIYDKLKEKNISYVDVTCPFV
                     LKIHRIVEKESLAGNHVIIIGDKDHPEVQGICGWCQGPYTVIKNQEEAEAFLLPEGKKI
                     SIVSQTTFNYNKFKDLVEIL"
ORIGIN
        1 ggtatcagtc atcataggag atgtgaagaa tctctttcat atgttcgata ggcattggtt
       61 cgcctgtcca taactcaaat gcagcggaac cctggaataa catcattccc agaccattca
      121 tagtcttaca tccaacttcc ttggccatgg aacgcatctt tgtttccagc ggagagtaag
      181 gaacatcaat aacgatcagc tcaggacgga agtaagattt gtccggaaca acggactggc
      241 cttccagagg tttcattccc acacctgtag catttacgaa aatgtagctg tcatccatct
      301 cagctttcag tttatcaaga tctgccagat cataaagaac tgcatggcag gatgtctttg
      361 tattgatctt ctctactgtg gatactgcac gatcccagaa ttcatccttg cggttaaaga
      421 ttgtgatctc ggcaacgccg tccaaagcag cctgaatctc gatagcagtg gcagcaccgc
      481 ctgcaccgac gatagtcatt ttctttccga tcacatcaat atcattatct ttcagggcag
      541 acataaatcc gataccgtca gtgatatgac ctgtaagatg accgttgtca tttacgatcg
      601 tgttaactgc accgcataat tctgctgcag gagaaagctc atccaggtat tttccaacca
      661 gagttttgtt tggcatggaa acattggatc ctctcatttt cagagtacgg attgctttta
      721 ctgcatcctc aatctcatct gcgccaacct cgaaagcaag gtaagcgtag tcatacccga
      781 gttttgcaaa agcctcattc tgcattgcag gagagctgga gtgacggatc gggtaagcca
      841 tcagaccgat taattcagta tgtccggtaa ttctttcagc cattataata tcccctttcg
      901 tattttgttg taaaggtttt tattgaaggt atcccatctg agtcagtgta ttaaggatat
      961 ttcttccttc cagagttccg tcgatgattc ttcttgcacg tttgctgtct ccgatgttca
     1021 ggatctcaac atcatcagaa acaaaagcat cggaaagctc tgcgaaaagc tgtccctgag
     1081 ctctcatacc aagacatacg aatccgtagt caaatggaag ctcacgttca ccttctgcat
     1141 cttttacaag gaaagagctg tcttttactt cctgaagagc tgtctttgta agctgggcca
     1201 catgatgttt cttcatctgg tccttcatgt cattctttgt aacaggatcc aggtcacgtc
     1261 cgatctgatc catcatctcc acaatagaaa tctcagcatt tcttgctgca aagaattcca
     1321 caacatcaag accaacagca ccgccgccca caacaacaac cttcttgcct gtcatatctt
     1381 ccggatagtc attgatgtga ttgatcattc ccaggataga agcaacctta ctgccttctt
     1441 tgtcaatgcg gtcgtgaagt cccctgatcg gaggaagcag tggcgcggaa cctgtggagc
     1501 ttacgatcag gttcggatgg aatttgcgga tattttccgg tgttccttct gtgtttgtga
     1561 agatataaag attctcaagc tgctctgctc tgtgaatcag atagttcggg aaatcagcca
     1621 gacgcttctt tgcaggaatc ttagagatca cagaagcaag accgccaaga gtctcacctt
     1681 tttccagaag gaaggtatta cagcctactt ctgcggctgt acaggcagct tccagtccgg
     1741 cagtaccgcc tccgattact acaacgttac agtttttgtt cactttctga ttcttataaa
     1801 catcaccttc cagaacagcc gggtttacag tacagcggat cggacggtta aagccgattc
     1861 tgtttcctgc acatccgatg ttacaggaga tacatttgcg aaggtcacat tctctgcctg
     1921 tagctacttt gtttacccat gcaggttctg cgataagacc acgtcccata ccgatcaggt
     1981 ctgcatcgcc gtcagcgagg atctgctcgg caacctttgg gttacggata tttcccatgg
     2041 agatacatgg tttgccgaat ttctctctga cagctttagg catataggaa cgccatccgt
     2101 ctttcatgta gttggcatcg atctgatact ggatagaacc gtttaaaccg caggaaacat
     2161 cgaagatatc aacttcatcc tgaacatatt ccagatattc aagagtatcc tcaagagtgt
     2221 tgccgccttc catcagctca tctgcgctga gacggagcat gatcgggaag gaaggtccga
     2281 cctgttttct tacttcttca atgaccatac ggcagaaacg tgttctgttt tccacagatc
     2341 cgccgaactc atctgtacgt ttgtttgtaa gaggagagag gaactggctg atcagatagg
     2401 aatgtcccgc atggatctct actgcgtcaa aacctgcagc ctgggctctt tttgcagcct
     2461 cgccgtattt ctttacaatg tgatggattt cttccactga taacggacgc gggatctctc
     2521 cgccttcttt ggacggaaca tcagatgcgg aaaccggctg catatttgta cgtgcggaaa
     2581 cagcggaagc acctgcgtgg ttgatctgga tcgcaataca ggtaccatat ttgtggatct
     2641 cttcacagaa tttgtacaga cgcggcagat agttgtcgtg gtcaatacga agctgagtag
     2701 ttccgttgga accctgcgga gaatctacgc ttgcattctc tacgatgatc agacctgtgc
     2761 cgcctttggc acgctcttta taataattaa tgtgaagaaa actcatttcg ccgttctgtt
     2821 ccccgtaatt ggttcccata ggcatcataa cgatacggtt tttgatagtc atatttttta
     2881 ctgtgagtgg tgtgaaaata tgctggtaat tgcttttcat tacgtctttc ctcctgaaat
     2941 tttctgttgt atctatagct gttcagtgct ttagctgtgg cctgaatttc tttgatgtgt
     3001 taattatata acgggataat ccataaatct aattgataat tcgtgctata taataaaaaa
     3061 catctatggt tttnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnntcttgca
     3181 ggatagaaat aagaaattca gacgcaggat tgttcgagaa atcaacttgt cgacacactg
     3241 gtttgcggga gagggtgaaa tacaggacaa tacaaaataa ccgtaatacc ctctattaaa
     3301 taggaagaaa tactcaaaaa aacaaaattt ggagaaacct gacaaatttt tctgctatat
     3361 ttttaacgaa aatgacaaat aaatgttgaa attttctgcc gaaaaaggta aaattaaaat
     3421 cggctaaatt tttgggttaa cttttaaata ttctcataaa gatggagggc aaacaagaat
     3481 gagtaatgca acacaaagct tagcaggcac aagaattact tctttgcttg acgcaaacag
     3541 ttttgtcgaa atcggacagg gtgtaacagc cagatccaca gatttcaaca tgactgcaaa
     3601 caaggcacca tctgacggtg ttatcaccgg atatggtgtg atcgatgaca aactggttta
     3661 tgtatacagc caggatgcat ctgtattaaa cggtactgtt ggtgaaatgc atgcaaagaa
     3721 gatcacaaga ctttatgatc ttgccatgaa aacaggcgct ccggttatcg gacttgttga
     3781 ctgtgcaggt atccgtcttc aggaagcaac agacgcactg gaagctttcg gacagatcta
     3841 tctgaaacag acactggcat ccggtgtgat cccgcagatc acagcaatct tcggaacatg
     3901 cggcggtggt atggcagtta tcccgtccct gacagatttc acattcatgg aatccaaaaa
     3961 aggaaaaatg ttcgtcaaca caccaaacgc actggaagga aacaacacag acaaatgcga
     4021 cacagcagca gctgatttcc agagcaaaga gacaggtgtg atcgatggcg ttggtacaga
     4081 ggatgagatt cttggccaga tccgttcctt agtatcactt cttccttcta ataatgaaga
     4141 cacagacaat tacacagagt gtacagatga tcttaaccgc gtatgcgcag atcttgcaaa
     4201 ctgtgcaggt gacacagcaa tcgcactttc ccagatcgct gacaacggtg aattcttcga
     4261 gacaaaagca gactatgcaa aagacatggt tacaggcttt atccgtttaa acggcgctac
     4321 agtaggtgct gttgcaaaca gaagcgaagt atatgacgca gaaggcaaga aaacagaaac
     4381 atttgacgga agcatctctg caagaggcgc aagaaaagca gcagatttcg tgaaattctg
     4441 cgacgctttt gatattccgg tacttacact tacaaacgca acaggcttca tggcaacctt
     4501 atgcagcgag aagatgatgg cgaaatccgt aggtgaactg gtagctgcat tcgcagatgc
     4561 aactgttccg aaggtaaatg tgatcatcgg caaagcttac ggtacagctt acgtggcaat
     4621 gaacagcaaa tctatcggtg cagaccttgt atatgcatgg gataacgcag agatcggtat
     4681 gatggatgct tccctggcag ccaagatcat gtatgcagat gcagatgctg ctgaactgaa
     4741 tgaaaaagct gctcagtaca gagagcttca gaatggtgtt gcttccgcag cagcaagagg
     4801 ctatgttgac actgtgatca gcccggctga cacaagaaaa tatgtaatcg gtgcatttga
     4861 gatgctgttc acaaagagag aagatcgtcc gtctaagaaa catggaacgg tctaagcggg
     4921 gtgacgcata tgaaaatgat caaaaaaata acttctgtat tcatgacatt tctcgtaatg
     4981 gctgcgctgg tgattggcag cacctctgtg gtatttgccg cagataaggt tgatgatact
     5041 gttaagtcca cactggtaac tacagcagaa ggactgacag atgccattgt ccagcttaaa
     5101 gatgaagaaa tcgagaatta catgagttca ggagatgact ttacaacaag tgccatgcag
     5161 tcctggcaga catccaagga tgaacttggc gcaaagaagg acagcaatgg tgaaactact
     5221 gtaactttca aagatgatca gtacacagtt actgttcctc ttaaatttga gaaagcagaa
     5281 gcaaactttg tatatgtctt tgactcacag ggaacaccga cttccatgtc tgtagatgta
     5341 cagtatggta tgggcaagac tcttcagaga gcaggtctta atactctgat gggtattgga
     5401 actgtattcg taatgctgat tttattaagc cttctgattt ctctgtttag atttattccg
     5461 aatccggaag caaagaaagc agcagaagca aaagcagcca aagctgcaaa agaggcagag
     5521 gcagcagcca tcgcacagac agcacctgca caggcagaag agaaccttgc agatgacgga
     5581 gagctggtag ctgttatcgc agcagctatc gcagcagcag aaggaactac aacagacggc
     5641 ttcgtagttc gttccatccg taaagtaaaa agaaatagaa gataattgtc atttatttag
     5701 gaggatttta aaatgaaaag ctatacaatt acagtaaatg gtacagcata tgaagtaact
     5761 gttgaagaaa caggaagcgt atccgctcct gcagcagctc caaaagcagc acctaaggct
     5821 gcacctgcag cagctccgaa agcagcagct cctgcagcag gcgccggcgc agtaaaagta
     5881 actgcttccg tacctggtaa agttgtcaaa gtagcagcaa gcgttggaca ggcagtaaaa
     5941 gccggagaca gcgtagttat tcttgaatcc atgaaaatgg aaatccctgt agtagctcct
     6001 caggatggta ctatcgcaag cattgatgtt gcagaaggtg cctctgtaga aaacggagat
     6061 actttagcaa caatgaacta agacgggagg tagtcaaatg tcttatgtaa cagaaacatt
     6121 gtccaacctg attcatcaga cagcattctt cagtttgaca tggggcaatt acctgatgat
     6181 cgcagtagcc tgcgtattcc tttaccttgc tatcaagaag ggattcgagc cgcttctgct
     6241 tgttcctatc gcattcggta tgctgcttgt aaatatctat ccggacatta tggcaaaccc
     6301 ggaagatatg tctaatggtg taggtggact tcttcattat ttctacatcc ttgatgagtg
     6361 gagtatctta ccatccctga tcttcatggg tgtaggtgcc atgacagact tcggtccgct
     6421 gatcgcaaac ccgatcagct tcctgatggg tgctgcagca cagcttggta tctatgcagc
     6481 ttacttcctt gcaatcttcc ttggattcaa cggaaaagca gcagcagcta tctccatcat
     6541 cggtggtgct gatggcccga cttccatttt ccttgcaggt aaacttggac agtctgcact
     6601 gatgggaccg atcgcagtgg cagcatattc ctatatgtca ctggttccga tcatccagcc
     6661 gcctatcatg aaactctgca caacagagaa agaacgtaag atcaaaatgg atcagcttcg
     6721 cccggtttcc aaactggaga agatcctgtt cccgatcgtt atcacaattg ttgtctgcct
     6781 gattttgcct acaacagctc cgctggttgg tatgcttatg cttggtaacc tgttcagaga
     6841 gtgcggtgtt gtaaaacagc tgacagaaac agcttccaat gccctgatgt atatcgtagt
     6901 tatccttctg ggtacatccg taggtgcttc cacaagtgca gaagcattct taaacgcaga
     6961 tactctgaag attgtagttt taggtcttgt tgcattcgca atcggtacat tcggcggatg
     7021 tatgcttggt aaactgctct gcaaactgac tcatggaaag atcaacccgc tgatcggttc
     7081 cgcaggtgta tccgcagtac ctatggcagc ccgtgtatcc cagaaagtgg gtgcagaggc
     7141 agatcctaca aacttccttc tgatgcacgc aatgggcccg aacgttgccg gtgttatcgg
     7201 tacagccgta gcagccggaa cattcatggc tattttcgga gtataaccaa atcaagcaag
     7261 ctatcttgct tgtatcagga ggagtgcaac tccttctgat aagctgcgga gcagctattt
     7321 ggttatgagc aagtagcgaa gcggattgcg aatatccgat taaacagaac tataaaggag
     7381 atttaataat ggcagaatta gagaaaaaac ctgttaaaat tgtggaaacc attctccgtg
     7441 atgctcatca gtcccagatc gcaacacgta tgaccacaga acagatgctt ccgatcgtag
     7501 ataaacttga taaagtcggc tatcacgcag tagagtgctg gggtggtgca acattcgatg
     7561 catcccttcg tttcctccac gaagatccat gggaaagact tcgtaaatta cgtgacggct
     7621 tcaaaaacac aaaacttcag atgcttttcc gtggacagaa catccttgga taccgtccat
     7681 acgcagatga cgttgtagaa tacttcgtac agaaatctgc tgcaaacgga atcgacatca
     7741 tccgtatttt tgactgcctc aatgaccttc gtaacctgca gacagcagta agcgctgcaa
     7801 acaaagagaa ggctcatgca caggtagctc tttcctacac attaggagat gcttacacac
     7861 tggaatactg gacagacatt gcaaaacgta ttgaagatat gggcgctgat tccatctgta
     7921 tcaaagatat ggcaggtctt ctccttccaa acaaagctac agagcttgta acagcattaa
     7981 aagaaacagt taagatcccg atcgaccttc atacacatta cacctcaggt gtagcttcca
     8041 tgacttactt aaaagcagta gaagcaggtg tggatatcat cgatacagca atgtctccat
     8101 ttgcactggg aacatcccag cctgcaacag aggttatggt tgagacattc aaggatacac
     8161 catacgacac aggatttgat cagaagcttc tctccgagat cgctgactac ttccgtccga
     8221 tccgtgacga agctcttgac agcggactgc tcaatccgaa gaaccttggt gttaacatca
     8281 aaactttact gtaccaggta ccgggcggta tgctctccaa cctgacttcc cagttaaaag
     8341 aacagcacgc agaagacaaa ttctacgatg ttctcgagga agttccgcgt gtacgtaaag
     8401 accttggtga accgccgctt gttactccgt cttcacagat cgttggtaca caggctgtat
     8461 tcaacgtact tatgggcgag agatacaaaa tggttacaaa agaaacaaaa gatatcctgt
     8521 taggaaaata cggcgcaact gtaaaaccgt ttaatccgga agtacagaag aagtgcattg
     8581 gcgatgagaa accgatcaca tgccgtccgg cagaccttct tgacaacgag cttgagaaac
     8641 ttgagagcga aatggctcag tacaaggaac aggatgaaga cgtattaaca tacgcactgt
     8701 tcccacaggt agctatggac ttcttcaaat accgtcaggc tcagaaaaca aaagttgacg
     8761 agaaagcagc tgacaaaaag aacggagcat atcctgtata attgatcagt aattaaatat
     8821 gtccaaatga aaaaaggagc ttgcgcaagc aggctccttt gcgttattat gaaagaatat
     8881 gatacccggg aatataatgt gccaatgggt atatgctgcc agtggtacat atctatattg
     8941 atcgtagcga agcggagacg tggaaccatg atgaaataga caatctgcag ggtaaaataa
     9001 atacaggaga atattccatg agcaaagtta taataatcgg cggcggagcc gccggaatga
     9061 tggcaggggt ttttgcagcc cgtaaccatc atgaagttca tatattagag aagaacgaga
     9121 aactgggaaa gaaagtcttc atcacaggaa aaggcagatg caatgtgaca aatgcctgcg
     9181 acacagaaga actctttcct gcaatgatga gcaatcccaa gttcctctac agcagtttct
     9241 attcatttac ccctcaggat gtaatggagt tctttgagaa agcaggtgtc cctctgaagg
     9301 tagagcgtgg aaacagagta ttcccacagt ctgaccattc ttcagacatc atccgcgctc
     9361 tggagcgtga gctgaagaaa gcaggagcaa agattcatct tcatactgct gtgcaggaaa
     9421 tcgtaaagaa acctgtaacg gaatctgtaa cagattccgt aaataccctt gaatcagaag
     9481 ccgcattaac agaatcagga tctgatgcag gaaaaagcag aaaaggaaaa aaatcatctg
     9541 acatacagca ggagaagatc acaggagtta tacttacaga tggtactttc atagaaggcg
     9601 atgcagtcat cgtggcaacc ggcggattct cttatcagag tacaggctcc acaggtgacg
     9661 gataccgctt cgcaagagaa ctgggactga aagtcacgga cattgctccc tcccttgtgc
     9721 cattaaagac aaaagaagac tatatcccta agcttcaggg actttccctt aagaatacag
     9781 gacttaccat aaagaatgga aaaaaagtac tttacgagga tttcggagag atgatgttca
     9841 cccatttcgg agtcacaggt ccaatgatcc tctccgccag tgcccacatc ggtgcaaaac
     9901 tggcgaaagc accaaacggc gaactgtccg catatctgga tctgaagcct gcactcacca
     9961 gagaacagct ggatgccagg atcctgcgtg aatttgaagc aggaccaaac aaacagttca
    10021 agaatgtgat tggcgtactt ttcccgtcat ctctgactcc ggtaatgctg gaactgggtg
    10081 gaatccccgc agagaagaaa atccacgaca tctccagaga agaacgccag cacttcattg
    10141 accttatcaa agccttcccc ttcacaatca caggaatggg tgagttcaaa gaagccatca
    10201 tcaccagagg cggcgtctct gtcaaagaga tcaaccccgg aacaatggaa tcaaagaaaa
    10261 tctcaggtct ttacttcgca ggcgaggtac tggatctgga tgcagtgaca ggtggatata
    10321 acttacagat tgcctggtct accgcatatc tggcagcgca ggctatacag taagctgaaa
    10381 caagcagatg atgagtacct tgtaggtgga tgatatctat gatatgattc agctatacgt
    10441 tatttaccga ttcataaaca tcaatcaata ataaaacaga gaaaatctgt ttgaataata
    10501 gaaacaggag gaaccacgaa aatgggatgt aacatagcca tcgacggacc tgcaggagca
    10561 ggaaagagca ccatcgcaaa gaaagtagcg aaagaattat catttatcta tgtagataca
    10621 ggagccatgt acagagcaat ggctttatat cttctgaacc atggcgtaaa cggagaaaat
    10681 caggaagaga tcgaggctgt atgttccggc gctgacattt ccatcgaata caaaaacgga
    10741 gaacagattg tcatcctcaa cggagagaac gtaaatgcta tgatccgcac cgaacaggta
    10801 ggaaacatgg catccaaaag ctccgcaaac ccgaaagtca gagcccacct tctgaaactt
    10861 cagagaactc tggcagagaa aaacgacgta gtcatggacg gcagagatat cggcacaacc
    10921 atccttccaa acgcagaagt aaaaatctac ctcacagcaa gcgcagacac cagagcaaaa
    10981 agaagagccc tggaatatga gcagaaggga gaagcctttg acctggaaca gatccgaaaa
    11041 gacatcatcg aacgtgacga acgcgacatg aatcgggaag tttctcctct gaaacaggca
    11101 gaggacgcag tgcttgtaga ttcttcggaa atgggaattg atgatgttgt aaatgcaatt
    11161 cttaatgtat ataaggaaaa agtgcagaaa taatttaaga aggattattt tatgaaagta
    11221 aaagtagcag aaacagcagg cttctgcttc ggcgtcaaac gtgcagtgaa caaagtctac
    11281 gaactcatag acacagaaca gaaacctatt ttcactctgg gcccgatcat ccacaacgaa
    11341 ggcgtagtag cggatctgga agctcgtggc gtccatgtta tcgcagaagc agacctggat
    11401 tccccggatg acaccctgca aaacggaaca gtagtcatcc gttcccacgg tgtaggcaaa
    11461 tctatctatg ataaactgaa agaaaaaaac atctcttacg tagatgtcac ctgtcccttc
    11521 gtcctgaaga tccaccgcat cgtggaaaaa gagagcctgg ccggaaatca tgtgattatt
    11581 atcggtgaca aagatcatcc agaggttcag ggaatctgcg gatggtgcca gggaccttac
    11641 acagtgatca aaaaccagga agaggccgaa gcattcctcc ttccggaagg aaaaaaaata
    11701 agcatcgtgt cccagacgac atttaattac aacaaattta aagatttagt tgaaattctt
    11761 t
//
