LOCUS       c00041_gnlPro..        14205 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NMBIKGBI_41.
ACCESSION   c00041_gnlPro..
VERSION     c00041_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 00:21:18
            Original ID  :: gnl|Prokka|NMBIKGBI_41
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14205
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14205
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[923:12646]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      924..12646
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14205
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /kind="single"
                     /product="OD_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14205
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="OD_AA_metabolism"
                     /region_number="1"
                     /rules="(minimum(1, [PFOR_II, POR, POR_N]) and minimum(2,
                     [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG,
                     Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /tool="gutsmash"
     CDS             2..274
                     /locus_tag="ctg41_1"
                     /transl_table=11
                     /translation="FSVSIPMFILAILCSGGLGGGDVKLMAASGVLLGIKWNIFAACAG
                     LLLGGLYGFFLLITKRAKRKDCFALGPFLCIGIAVVFFRYIFMKV"
     CDS             924..2825
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: POR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_2"
                     /sec_met_domain="PFOR_II (E-value: 7.5e-18, bitscore: 53.8,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 2.7e-78, bitscore: 251.7,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 2.9e-36, bitscore: 114.1,
                     seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRAKQSMDGNTAAAHVAYAYTDVAAIYPITPSSPMADSVDQWAA
                     AGQENIFGNQVVVSEMQSEAGAAGTVHGSLAAGAITTTFTASQGLLLMIPNMYKIAAEQ
                     LPCVFDVSARTVATQSLNIFGDHSDVYACRQTGFAMLAETNPQEVMDLSPVAHLAAIEG
                     KVPFINFFDGFRTSHEIQKIEKWDYADLKEMCNMDAVKAFREHALNPEHPAMRGSHENG
                     DVFFQHREACNSVYEALPAVVKKYMGKINEKLGTNYDLFNYYGAEDADRVIIAMGSICD
                     VAEEVIDYLTAKGEKVGLIKVRLYRPWVSSALLDVIPKTAKKIAVLDRTKEPGALGDPL
                     YLDVATTLREAGLNDIVLTAGRYGLGSKDTPPSSVFAIYKELEKDAPKSRFTIGIVDDV
                     TNLSLPEVKPAPITSAPGTVECKFWGLGGDGTVGANKNSTKIIGDHTDKYIQAYFQYDS
                     KKTGGITISHLRFGDNPIRSPYYINQADFVACHNPSYVVKGYKMVQDVKPGGIFMINCQ
                     WSDEELDHHMPAAAKKYIADNNIQLYTINAIDKAIEIGMGKRTNTILQSAFFKLANIMP
                     IDEAVEFMKAAAKKSYSKKGDAVVEMNYKAIDAGVDAVHKVEIPASWSNPADDSTAN"
     CDS             2865..4481
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) EKR"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-13, bitscore:
                     39.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_7 (E-value: 1.1e-11, bitscore: 34.3,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 5.9e-08, bitscore: 21.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.4e-05, bitscore: 12.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 8.5e-17, bitscore: 49.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEPIGIMDGDSLPVSTFVDNADGQFELGASAYEKRGTAVSVPEW
                     NPEACIQCNQCAFVCSHATIRPFLVSEDEIKAAPDNMKVADTKPKASEYKFTMSVSPLD
                     CMGCGECITVCPAAAKGALKMVPQESQAAEQPVFDYLVATVGRKPGAPADTTVKGSQFN
                     QPLLEFSGSCAGCAETSYARLITQLFGEHMYISNATGCSSIWGGPAATAPYTVNKDSKQ
                     GPAWANSLFEDNAEHGFGMYLGQKTLRDQAIAKLEKMAASDKASDEFKAAFAKFMETKD
                     NTKENTPDAQALIAEVEKAAAAGCPDAAEVLEKKQYLAKKSVWIFGGDGWAYDIGFGGL
                     DHVLASGENVNVMVFDTEMYSNTGGQASKASNIGEVCQFAAAGKEISKKSLAEIAMSYG
                     YVYVAQIALGANPNQAVKCLAEAEAYNGPSLIIGYAPCELHGIAKGGMNHCQDEMKKAV
                     KAGYWNLFSFDPAKKAEGKNPFTLTSKEGDGSYQEFLNNESRYTRLIKPFPERAERLFN
                     ESEKVAKARYEHLQRLVELYK"
     CDS             4679..6433
                     /locus_tag="ctg41_4"
                     /transl_table=11
                     /translation="MLYKEDFGEGKNIEFKREIPKRHEKLLKDVIAFSNSTGGKIFIGI
                     EDKTNEVIGIGEKNPFRLADDISNMIFDSCTPIIDPEITIQTLEGRTVVVVEVFPGRMR
                     PYYLKSFGKEQGSYIRINGTSRPADDRKLKELELEGQKISYDTLPEIDMEYSEREAKIL
                     CNAMEKVAYDVQTTCVTRAIQETSLDPKQNTEKTEIINKMTIEKLEDLGLLCRIGKDLQ
                     PTHAFRLMTKNKIRYAKIQCALFKGTERDIFIDKREFDGPLYVQLENAYQFVLKHINLG
                     AKIEGLHRKEAYELPVRTIRELITNAVVHRSYLDESCIQVCVYDDRIEVTSPGMLYGGL
                     DIQSAKSGKSKCRNTAIAEAFRYMGLIEAWGTGIPRMIKECREYGLREPVFEELGDGIR
                     VTIFRENEELEMRKRAENIQNAENKYQYMNNINSENLASVVKEQTVEYREQNHCFNTEK
                     SLFNALDSQGNEKKYCLNDEKTLFETTSQDKTHCFETSVLTAENKYMLYKKLKELQVNK
                     SIGSVTALNIKEIIESFSGEEVFGRKEIKQKLGYKDSKAGFLIQTMREFELIKAVKGRG
                     KGKYCFDI"
     CDS             complement(6602..7204)
                     /locus_tag="ctg41_5"
                     /transl_table=11
                     /translation="MIINKFYEKLYKELINKLESDYILIPNTPENRKAINNTLTTVPCT
                     VKSLEKDSKIFKALSNKKAKAKQLSIVPKISKTLSLIIIATLICMPFNTINTLPTPTYH
                     PTVQVSILDISDGSSHQKGKNKLSEIQEQYTNKNQEQRNPKNYKKKVATNTYNTYKKQN
                     KFHLTLSTKKQLNFYQLLKSFFLKQKIHTIIYLMLMM"
     CDS             8111..12646
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: Glu_synthase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: Glu_syn_central"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_6"
                     /sec_met_domain="GATase_2 (E-value: 5.9e-173, bitscore:
                     564.2, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Glu_syn_central (E-value: 1.4e-112,
                     bitscore: 364.6, seeds: 570, tool: rule-based-clusters)"
                     /sec_met_domain="Glu_synthase (E-value: 9.1e-154, bitscore:
                     500.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYQDNMRQGLYDPSLEHDNCGIGAVVNIKGLKSHETVSNALKIVE
                     NLEHRAGKDAEGKTGDGVGILVQISHKFFEKTCSTLGFSIGKERDYGIGMFFMPQDELQ
                     RNRAKKMFEIIVEKEGLNFLGWREVPVQPGILGKKAADCMPCIMQGFVKRPFDVPRGLD
                     FDRRLYIVRRVFEQSNDSAYVVSLSSRTIVYKGMFLVGQLRLFYNDLQDKDYESAIALV
                     HSRFSTNTVPSWEKAHPYRYIVHNGEINTIRGNADKMLAREENMESDYLKDEMIKLTPV
                     VDPNGSDSARLDNTLEFLLMSGMPLPLAMMITIPEPWENNEGMSREKRDFYQYYATMME
                     PWDGPASILFTDGDIMGAVLDRNGLRPSRYYITDDDQLILSSEVGVLDFDTTHIVKKER
                     LHPGKMLLVDTVKGELIDDEILKDSYVKNQPYGEWLSDNLVFLKDLKIPNVAVEEYSYE
                     ESNRLMKAFGYSYEEVKDSVLPMALNGSEAIGAMGVDTPLAVLSKRHHPLFDYFKQLFA
                     QVTNPPIDAIREEIVTSTSIYVGGEGNVLEEKAENCHVLKIHNPILTNTDLLKIRYAKV
                     KNINVKDVPITYYKGTPLDKAINHLYVAVDQAHKNGANVVILTDRGVDENHVAIPSLLA
                     VSAVHHHLIETKKSTSVSIILESGEPREVHHFATLLGYGACAINPYLAQFSIKKLIQDG
                     LLKKDYYAAVNDYNNAVLHGIVKIASKMGISTLQSYQGSQIFEAVGISKKVIDEYFTNT
                     VSRVEGITIEDIAEDVDYHHSKAFDMLGLKNDLSLDSEGDHKYRSGKEEHLYNPLTIHT
                     LQTAAWTNNYELFKQYTSMINKETSPVSLRGLMDFNYPSKGVPIEEVESVDSIVKRFKT
                     GAMSYGSISKEAHETLAIAMNMIHGKSNTGEGGEDLERLTVGPDGLNKCSAIKQVASGR
                     FGVTSRYLVSAQEIQIKMAQGAKPGEGGHLPAGKVYPWIAKTRHSTPGVGLISPPPHHD
                     IYSIEDLAQLIYDLKNANRNARISVKLVSEAGVGTVAAGVAKAGAQVILISGHDGGTGA
                     APRNSSIHNAGLPWELGLAETHQTLIKNDLRNKVIIETDGKLMSGRDVAMAAALGAEEF
                     GFATGPLITMGCVMMRVCNLDTCPVGIATQNPELRKRFKGKPEYVVNYMKFVAQEMREY
                     MAKLGVRTVDELVGRTDLLKELPEAKEYHLDLSAILNNPYVDKKHPICYNKKNEYNFEL
                     EKTLDEKVLLTKLKTALDKKQKRSISIDVGNTDRSFGTIFGSEITKKYYNTLEDDTFTV
                     QCTGAGGQSFGAFIPNGLTLELVGDSNDYFGKGLSGGKLIVYPPKGIRFKAEENIIVGN
                     VALYGATSGQAYINGVAGERFCVRNSGATAVVEGVGDHGCEYMTGGKVLIIGKTGKNFA
                     AGMSGGVAYVLDEDNDLYLSLNKEMVSSEPVVSKYDVMEIKDMITAHVAYTNSEKGKEI
                     LNDFSKYLPKFKKIIPHDYKKMLKKISEMEGKGLSAEQAQIEAFYEIKRG"
     CDS             12659..14143
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_20"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:Dihydroprymidine dehydrogenase domain II, 4Fe-4S
                     cluster (Score: 69.9; E-value: 4.8e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_7"
                     /sec_met_domain="Pyr_redox_2 (E-value: 8.6e-27, bitscore:
                     82.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_20 (E-value: 5.4e-23, bitscore: 69.9,
                     seeds: 204, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKPTGFLEYERKESVGEAPLKRIKHFNEFHTPLSKKEQERQGAR
                     CMNCGVPFCQSGILIKGMVTGCPLNNLIPEWNDATYTGNWDEAYNRLRKTNPFPEFTGR
                     VCPHPCEVGCTCNLGGDPVNIKEKELSIIERAYESGLIKPEPPEVRTGKTVAIVGSGPS
                     GLCVAEYLNRRGHSVTVYERSDRVGGLLMYGIPNMKLEKTYIERKVKLMEKEGVVFKTG
                     VNVGVDVKAQDLKKQYDAVVLCCGASNPRDIKAPGRKSKGIYFAVDYLKAATKSLLDSN
                     FADKKYIDAKDKNVMVIGGGDTGNDCVGTSIRLGCKSLIQLEMMPKLPDERQPNNPWPE
                     WPRVCKTDYGQEEAIAVFGKDPRVYQTTVKEFIANEKGEVCKAKLVKLESKFDKKAGRN
                     IMAEVAGSEYEVPVDLVLIAAGFLGSQPYVTKAFGLDLTERTNVKTVEGHFKTNVDKVF
                     TAGDMHRGQSLVVWAIREGRDCAREVDKALMGYSNL"
ORIGIN
        1 gttttcggtt agtattccga tgttcatact tgcaatttta tgttcaggcg gactgggtgg
       61 aggagatgtt aagctaatgg cggcaagtgg agtgttacta gggataaagt ggaatatatt
      121 tgctgcttgt gcgggattac ttttaggagg attatatgga ttttttctac tgattacaaa
      181 gcgtgcgaag cgaaaggatt gctttgcgct gggacctttt ttgtgtatag ggattgccgt
      241 tgtgtttttt agatatattt ttatgaaagt gtgagggaga taatatggaa ttaccgtgga
      301 ttcccactta attttctttt catcacttct gagtaaaaag tcgtttttcg tgaattgtct
      361 cattgacatt ttgtcaaata acgtgcctgt tttcctatag agttgtgttg gcttcattca
      421 gttgacgtag ccgcccgtta tgctgccctc attcatgcac aatctcccgc aaattgtgac
      481 acacatcttg cagaaagcat ttttcaaaca cgttctagtc gattaaatta tgtaaaatta
      541 cgaaattgtt atttttaaaa gatggagata aatggtgaaa acaaagagga atctcataaa
      601 ataattaaaa aatgaagaaa aaatattaga attttaatcc tgaataatcc taaaattaca
      661 acaaaaaatt attgagaaaa aatctaaaat aagccatatg tatattgtat acaaaactgt
      721 tggctttata gcaattttaa cctaaaattg ttctcggaaa aatacgttgt caaggggaaa
      781 aattggcata aaaaggctgt ttcgggcaag attttgtatt ttagaaggaa cagttccgaa
      841 taagctttac attacctcaa aaaaatgata atattatgtc gaatttaaaa taaaccacaa
      901 cttttgacaa ggaggaataa tcaatgccta gagcaaaaca gtctatggat ggaaataccg
      961 cagcagctca cgtagcatat gcgtatacag atgttgcagc tatctatcct attacaccat
     1021 ctagtccaat ggctgattcc gttgaccagt gggcagcagc aggacaggaa aatatttttg
     1081 gtaaccaggt agttgttagt gagatgcagt ctgaggcagg tgcagcaggt actgttcacg
     1141 gttctcttgc agctggtgct atcacaacaa catttacagc atcccagggt cttcttctta
     1201 tgatccctaa catgtataag atcgcagctg agcagcttcc atgtgtattt gatgtatctg
     1261 cacgtacagt tgctacacag tctctgaaca ttttcggtga ccacagtgac gtatatgcat
     1321 gtcgtcagac aggatttgct atgctggcag aaactaaccc acaggaagtt atggacttaa
     1381 gccctgtagc acatcttgct gcaatcgaag gtaaagttcc attcatcaac ttcttcgatg
     1441 gattccgtac ttctcatgag attcagaaga tcgaaaaatg ggattatgca gacttaaaag
     1501 aaatgtgcaa catggatgca gttaaagctt tccgtgagca tgctcttaac ccagaacacc
     1561 cagctatgcg tggttctcac gaaaacggtg acgttttctt ccagcacaga gaagcttgta
     1621 actctgttta cgaagcttta ccagctgttg ttaagaaata catgggcaaa atcaacgaaa
     1681 aactgggaac taactacgat ttattcaact actatggtgc agaagatgca gaccgcgtaa
     1741 tcatcgctat gggatctatc tgtgacgtag cagaagaagt aattgattac ttaacagcaa
     1801 aaggtgaaaa ggttggttta atcaaagttc gtttatatcg tccttgggta tcttctgcat
     1861 tattagacgt tattcctaag acagctaaga agatcgctgt tcttgaccgt acaaaagagc
     1921 ctggagcatt aggagatcct ttatatcttg atgttgctac aactcttaga gaagcaggtc
     1981 ttaacgatat cgttcttaca gctggacgtt acggattagg ttctaaagat actcctcctt
     2041 catctgtatt tgctatttat aaagaacttg aaaaagacgc tccaaagagc cgtttcacaa
     2101 ttggtatcgt ggatgatgtt acaaacttat ctttaccaga agttaaacca gctcctatta
     2161 catctgctcc tggtacagta gagtgtaagt tctggggtct tggtggagac ggtactgtag
     2221 gtgctaacaa gaactctaca aagatcatcg gtgaccacac agataaatac attcaggcat
     2281 acttccagta tgactccaag aagacaggtg gtattacaat ttctcacctt cgttttggtg
     2341 acaatccaat cagaagccca tactacatta atcaggctga cttcgtagca tgtcacaacc
     2401 catcttatgt agttaaaggt tacaagatgg ttcaggatgt taaaccaggc ggaatcttca
     2461 tgatcaactg ccagtggtct gatgaagaat tagatcatca tatgcctgca gcagctaaga
     2521 agtatattgc tgacaacaac attcagttat acacaatcaa cgcgattgat aaggctatcg
     2581 agattggtat gggtaaacgt actaacacaa tcttacagtc cgcattcttc aaattagcga
     2641 acatcatgcc tatcgacgaa gcagtagaat tcatgaaagc agcagctaag aagtcctaca
     2701 gcaagaaggg tgacgctgtt gtagagatga actacaaagc tatcgacgct ggtgtagatg
     2761 ctgttcataa agtagagatt ccagcttcct ggtctaaccc agctgatgat tctactgcta
     2821 actaacttac aggacgtaca gagacagtga agattgttaa gaaaatgatg gaacctatcg
     2881 gaatcatgga tggtgacagc ctgccagtat ctacattcgt agacaacgct gacggacagt
     2941 tcgaacttgg tgcttccgca tacgaaaaac gtggtactgc tgtatctgtt ccagaatgga
     3001 atccagaagc ttgtatccag tgtaaccagt gtgcgtttgt atgttcccat gctacaattc
     3061 gtcctttctt agtaagcgaa gacgaaatta aggcagctcc tgacaacatg aaagttgcag
     3121 atacaaagcc aaaggcaagc gaatacaaat ttacaatgag cgtatctcca ttagactgta
     3181 tgggatgtgg tgagtgtatc acagtttgtc ctgctgcagc taagggcgca ttaaagatgg
     3241 ttccacagga aagccaggca gcagaacagc cagtattcga ttacttagtt gcaactgttg
     3301 gaagaaaacc aggtgctcct gcagatacta cagttaaggg atctcagttc aaccagccat
     3361 tacttgagtt ctccggatct tgtgcaggat gtgcagagac atcttacgct cgtctgatta
     3421 ctcagttatt cggagagcat atgtacatct ccaacgcaac aggatgttca tccatctggg
     3481 gtggtcctgc agcaacagct ccatatacag taaacaaaga ttccaaacag ggaccagctt
     3541 gggcaaactc cttattcgag gataacgcag agcacggctt tggtatgtat cttggacaga
     3601 agactttacg tgaccaggct atcgctaaat tagagaagat ggcagcatcc gataaagcat
     3661 ccgatgaatt taaagcagca tttgctaagt tcatggaaac aaaagacaat acaaaagaaa
     3721 atacacctga tgctcaggca ttaatcgctg aggtagaaaa agcagcagca gctggatgcc
     3781 cagatgcagc agaagtatta gagaagaaac agtatctcgc taagaagtcc gtatggatct
     3841 tcggtggtga cggatgggca tatgatatcg gtttcggtgg attagatcat gtattagctt
     3901 ccggtgagaa cgtaaacgtt atggtattcg atactgagat gtactccaac acaggtggac
     3961 aggcttctaa agcttctaac atcggtgagg tttgtcagtt cgcagcagct ggtaaagaaa
     4021 tcagcaagaa gagccttgca gagatcgcta tgagctacgg atacgtatac gttgcacaga
     4081 ttgctcttgg tgctaaccct aaccaggcag ttaaatgtct tgcagaagca gaagcttaca
     4141 acggaccatc cctgatcatc ggatacgctc catgtgaact tcacggtatc gctaagggtg
     4201 gtatgaacca ctgccaggat gagatgaaga aagccgttaa ggctggttac tggaacctct
     4261 tctccttcga cccagctaag aaagctgaag gaaagaatcc attcacatta acatctaaag
     4321 aaggcgatgg atcatatcag gaattcttaa ataacgaatc ccgttacact cgtctgatta
     4381 agccattccc agaaagagct gaaagactct tcaacgaatc tgagaaggtt gctaaggctc
     4441 gttacgagca cctgcagaga ctcgttgagc tttataaata ataaagcctg aactggtcag
     4501 tcagattagt tacaaaagat aaaactttat aaaatacaaa agagaagccg tgtgctagct
     4561 atgctggtgc atggcttctt cttgtgtgtt gaaaaaaaga agggaattgt attataataa
     4621 atcataacaa attaatgact gatagatgta ctgacaatgg ttttgaagag ggacaggaat
     4681 gctatataaa gaagattttg gagaaggaaa aaatatagaa tttaaaagag agataccgaa
     4741 aagacatgag aagttattaa aagatgttat tgctttttcc aattctacgg ggggtaaaat
     4801 ttttattgga attgaggata agacgaatga agttattggg attggagaga agaatccatt
     4861 tagattagca gatgatattt caaatatgat atttgacagc tgcactccaa taattgatcc
     4921 ggaaattaca atacagacat tagaaggaag aacagttgtt gttgtagaag tttttccagg
     4981 acgtatgcgt ccttattatc tcaagtcatt tgggaaggaa caaggttctt atataagaat
     5041 aaatggtaca agtcgtcctg ctgatgatag aaagttaaag gaactagaat tagaaggtca
     5101 aaagatttct tatgatactt taccggaaat agacatggag tactcggaac gagaggcgaa
     5161 gatattatgt aatgcaatgg aaaaagtggc atatgatgtg cagacaacat gtgtaacaag
     5221 agcaatacag gaaacgtcat tagatcccaa gcaaaataca gaaaaaactg aaattataaa
     5281 taaaatgaca atcgagaaac tagaagactt agggttattg tgccgaatag gaaaagacct
     5341 tcaacccacc catgcgttta gactaatgac gaagaataaa atacggtatg ccaaaattca
     5401 atgtgcgtta tttaaaggaa cagaaagaga tatttttata gataaaagag aatttgatgg
     5461 accattatat gtacagctgg aaaatgctta tcaatttgta ttaaagcata tcaatcttgg
     5521 tgcaaagata gaagggttac atagaaaaga agcgtatgaa ctcccggttc gaacaataag
     5581 agaattgatt actaatgcag ttgttcatag aagttatttg gatgagtctt gtatacaggt
     5641 ttgtgtctat gatgacagga tagaagtaac atctcccgga atgctttatg ggggactgga
     5701 tatacagtca gctaaatcag gtaaatcaaa gtgcagaaat acagcgattg ctgaagcatt
     5761 tcgttatatg ggacttatag aagcgtgggg aacaggaatc ccaagaatga taaaagaatg
     5821 cagagaatat ggattgagag agccagtgtt tgaggaactg ggagatggta tacgagtaac
     5881 tatattccgg gaaaatgaag aattggagat gcgaaaacgg gcggagaata tacagaacgc
     5941 tgaaaataaa taccagtata tgaataatat aaatagtgag aacttagcat ctgtagtaaa
     6001 agaacaaaca gtggaatata gagagcaaaa tcactgtttc aatacagaaa aatcactgtt
     6061 taatgcgctg gattcacaag gaaatgaaaa aaaatactgt ttgaatgatg aaaaaacact
     6121 gtttgaaaca acaagtcagg ataaaaccca ctgttttgaa acgtctgtat tgactgcaga
     6181 gaataaatat atgttatata aaaagctgaa agaactacaa gttaataaaa gcataggtag
     6241 cgtcactgca ttaaatataa aggagattat cgaaagcttt tcaggagaag aagtctttgg
     6301 gcgaaaagaa ataaaacaaa aactgggata taaagacagt aaggcgggat ttctgattca
     6361 aacaatgcgg gaatttgagt tgattaaagc tgtgaaagga aggggcaagg gaaagtattg
     6421 ttttgatatt taaaactcta tcttggcttt cataagaaaa tttaaagccg tacttctgtg
     6481 aagaacggct ttaatgtata attgaaaata gtattgaata aaattatata gaaggactat
     6541 tttaattttt ttgagcgtat agattctttt actgtggaaa tcaatacaaa taaagtacta
     6601 attacatcat aagcatcaga taaattatcg tatgtatttt ttgttttaag aaaaaacttt
     6661 ttaaaagttg ataaaagttg agttgctttt ttgtggataa tgttaaatgg aatttatttt
     6721 gtttcttata tgtattatat gtatttgtag caactttctt tttgtagttt ttaggattac
     6781 gttgctcttg gtttttgttt gtgtattgtt cttgtatttc ggataattta tttttccctt
     6841 tttggtgaga agatccatca gaaatatcta aaatactaac ttgtacagta gggtggtagg
     6901 taggcgttgg gagagtgtta atggtattaa atggcataca aattaaagtg gctattataa
     6961 taagagataa agttttagaa attttgggta caattgaaag ctgcttagct ttagcttttt
     7021 tgttagataa agctttaaaa atctttgaat ctttttctaa agattttaca gtgcaaggga
     7081 ctgtcgttag agtattatta attgcttttc tattttctgg cgtgttaggg attaaaatat
     7141 aatcagattc tagtttgttg ataagttcct tgtagagttt ttcataaaat ttgttaataa
     7201 tcattgtgat ttcttctttc ttttttctat aataataaat gcgtattttt ttgcgaaatg
     7261 gcctctcctt tctgtatcga atttcaacat tttttgttga ttattattaa tatgtataat
     7321 tttttctttt tgtattgctc tgatttgcca tgtgtgtaat taaaatctcc tttcttacat
     7381 tagtatgaga gattagggaa attttctttt tgaaaagata gtttacgaaa aaagaatccg
     7441 attctttttt tgctttttca ctacaaatag tatgctagtt tagacaatgg aataaaattg
     7501 tagaattcaa ccaattactt acttaatttt cttaagttat tttgtataca atgttaataa
     7561 aatgcaggat ttgtatttga aaattacatt tataattgta tgaattgtct ttaaatctga
     7621 aaataacgat gaataaagag gtgaaatcac aaacaaaatt gtacttttat aagaacaata
     7681 taatctaaaa agaaataaaa accaaataaa ctaactacaa tatcccctaa aacaagagta
     7741 ataatcagaa aataatatat taaaaaataa ataatcaaat tattagacaa ctcaccttaa
     7801 tgtttatatt tacaacctat ttaaaatgtt gtaatatgat aacaacaaaa agaaatgcag
     7861 gaagtcatta caactacttc tgaaaatgaa tttgttactt tttaaatatg taattattca
     7921 gagatttata gatttttatt cagactatag atactcattc aggattatga aatcataaga
     7981 ttacaagagc atgagaacat gagaatcata aggtttgatt aagagttcct gataattact
     8041 aattacaaaa atataattta caactgatga atatttacta tttcatagtg atgcaagaaa
     8101 gggtgagacc atgtatcagg acaatatgcg acagggtcta tatgatccaa gtctggagca
     8161 tgataactgt ggtattggtg ctgtagtaaa catcaagggt cttaagagcc atgagacagt
     8221 atcgaatgcc ttgaaaattg ttgaaaatct tgaacataga gccggcaagg acgccgaggg
     8281 taaaacgggt gacggagtag gtatcttagt gcagatatcc cataagttct tcgaaaaaac
     8341 ctgtagtact ctcggctttt ctattggcaa ggaacgtgac tacggtattg gtatgttctt
     8401 tatgccacag gatgagttac agagaaaccg tgctaagaag atgtttgaga ttatcgttga
     8461 aaaagaaggc ttaaatttct taggctggag agaggttccg gttcagccgg gcatcctcgg
     8521 aaagaaagca gcggactgta tgccatgcat tatgcaggga tttgtaaaga gaccgtttga
     8581 tgttccacga ggacttgact tcgatagaag actttatatt gtaagacgag tatttgagca
     8641 gtctaacgat tctgcttatg ttgtttcttt aagcagcaga acaatcgtat ataaaggtat
     8701 gttcttagtt ggacagttaa gattattcta taatgacctt caggataagg attatgaatc
     8761 tgcaatcgca ttagttcatt cccgtttctc cacaaacaca gttccaagct gggagaaagc
     8821 acatccttat cgttacatcg ttcataatgg tgagattaat actattcgtg gtaatgccga
     8881 taagatgtta gcccgtgagg aaaacatgga atctgattat ctgaaggatg agatgattaa
     8941 gctgacacca gttgtagatc caaacggttc tgactctgca agattagata atacattaga
     9001 attcctctta atgagtggaa tgccacttcc tctggcaatg atgatcacga ttccagaacc
     9061 ttgggaaaat aacgagggca tgagcagaga gaagagagac ttctatcagt actacgcaac
     9121 aatgatggag ccttgggatg gtcctgcatc tatcctcttt acagatggag atatcatggg
     9181 agccgtactt gaccgtaatg gtcttagacc ttcccgttac tatattacag atgatgacca
     9241 gttaattctt tcttctgagg ttggtgtgtt agactttgac acaacacata tcgtaaagaa
     9301 agagagactt cacccaggta aaatgcttct cgtagatact gtaaaaggtg agctgattga
     9361 cgatgaaatc ttaaaagatt cttatgtaaa gaatcagcct tacggtgaat ggttatccga
     9421 taaccttgta ttcttaaaag acttaaagat tccgaatgtt gcagtagaag aatacagcta
     9481 tgaagagagc aaccgcctga tgaaagcatt tggttactct tatgaagaag tgaaagattc
     9541 tgtattaccg atggcattaa acggaagtga agcaatcgga gcgatggggg ttgatactcc
     9601 attagcagta ctttctaaga gacatcatcc attatttgat tactttaaac agctttttgc
     9661 acaggtaaca aaccctccta ttgatgcgat tcgtgaggaa atcgttacat ctacttccat
     9721 ctatgttggc ggagagggga atgtgttgga agaaaaggca gaaaactgcc atgtattaaa
     9781 gattcacaac cctattttaa caaatacaga cttattaaag attcgttatg caaaggtaaa
     9841 gaatatcaat gtaaaagatg tgccgattac ttattacaaa ggaacaccgc ttgataaggc
     9901 tatcaatcat ttatatgttg ctgttgacca ggcgcataaa aatggtgcaa atgttgttat
     9961 tttgacagat agaggtgttg atgagaacca tgtggcaatt ccatctctgt tagcagtatc
    10021 tgctgtacat catcatctca ttgagacaaa gaagagtact tctgtaagta ttatcttaga
    10081 gagtggtgaa ccaagagaag tacatcattt cgccacactg ttaggttacg gcgcatgtgc
    10141 tatcaaccca tatctggcac agttcagtat taagaagctg attcaggatg gtttattaaa
    10201 gaaagattac tatgcagcag taaatgatta caataacgca gtacttcacg gtatcgtaaa
    10261 gatcgcatct aagatgggta tttccacact gcagtcctat cagggttctc agatttttga
    10321 ggcagttggt atcagcaaga aagtcattga tgagtacttt acaaacacag taagccgtgt
    10381 agaaggtatc acaattgaag atatcgcaga agatgtagat taccatcact ccaaagcatt
    10441 tgatatgtta ggactgaaaa atgatcttag tcttgacagt gaaggtgatc acaaatatag
    10501 aagtggtaaa gaagaacatc tttacaatcc actgaccatc catacattac agacagcagc
    10561 atggacaaat aattatgaac tgtttaaaca gtatacttcc atgattaata aagaaacttc
    10621 tccagtaagt cttcgtggat taatggattt caattatcca tccaaaggag ttcctatcga
    10681 ggaagttgaa tctgtagatt ctatcgtgaa acgatttaag acaggtgcta tgagttatgg
    10741 ttctatttcc aaggaagcac atgagactct ggcaatcgcg atgaacatga ttcacggtaa
    10801 atcaaacact ggtgaaggtg gagaagattt agagcgtctg acagttggtc cagatggact
    10861 gaataaatgc tctgcaatca agcaggtagc ttccggtcgt ttcggtgtaa caagccgtta
    10921 ccttgtaagt gcacaggaaa ttcagattaa gatggcacag ggagcaaaac ctggtgaagg
    10981 tggacattta ccagcaggaa aagtatatcc ttggattgca aagacaagac attcaacacc
    11041 tggtgtagga ctaatctcac caccacctca tcacgatatt tacagtattg aagatttggc
    11101 acagttaatt tatgatttga aaaatgcaaa cagaaatgcc cgcatttctg taaaactggt
    11161 atctgaagca ggtgtcggaa cggtcgcagc cggtgtagca aaagctggcg cacaagtaat
    11221 ccttatttcc ggacatgacg gtggtacagg tgcagcacct cgtaattctt ctatccataa
    11281 tgccggactt ccgtgggagc ttggacttgc tgagacacac cagacattaa ttaaaaatga
    11341 ccttcgtaat aaagttatca tcgagacgga cggtaagctt atgagcggcc gcgacgtagc
    11401 aatggcagca gcacttggag cagaagaatt tggatttgct actggtccgc tgattacaat
    11461 gggctgcgtt atgatgagag tttgtaactt agatacttgt ccagtaggta tcgcaacaca
    11521 gaatccggaa cttagaaaac gttttaaagg taaaccggaa tacgttgtaa actacatgaa
    11581 gttcgttgca caggaaatgc gtgaatacat ggcaaaactt ggtgtccgca ctgtagatga
    11641 actagtagga cgtacagacc ttctgaaaga acttccagaa gcaaaagagt accacttaga
    11701 tttatctgct attttaaata atccatatgt agataagaag catccaatct gctacaacaa
    11761 gaagaatgaa tacaactttg aattagaaaa gacattagat gaaaaagttc ttcttactaa
    11821 gttgaagaca gcgcttgata aaaagcagaa gagaagcatt tctatcgatg ttggaaatac
    11881 agaccgttcc tttggtacaa tctttggttc tgaaattaca aagaaatatt acaacacact
    11941 ggaagatgat acatttactg tacagtgtac aggagccggc ggacagagct ttggagcatt
    12001 tattccaaat ggtcttacat tagagcttgt cggtgacagt aatgactact tcggaaaagg
    12061 attatccggt ggtaaattaa tcgtttaccc tccaaaagga atccgcttca aagccgagga
    12121 aaatattatc gttggtaacg tagcacttta cggtgcaaca agcggtcagg cttatattaa
    12181 tggtgtggct ggtgaacgtt tctgtgttcg taactccggt gcaacagctg ttgtagaagg
    12241 tgtcggcgat cacggatgcg agtacatgac tggtggtaaa gtcttaatta tcggtaagac
    12301 tggaaagaac ttcgcagccg gaatgagcgg cggtgttgcc tacgttcttg atgaggataa
    12361 cgacttatac ttaagcctca acaaggaaat ggtttcttcc gaaccagttg tttctaaata
    12421 tgatgttatg gaaattaagg atatgattac cgcccatgtg gcatatacaa actctgaaaa
    12481 aggtaaagaa attttaaatg attttagcaa atatttaccg aagtttaaga aaatcattcc
    12541 acacgattac aagaaaatgc tcaagaagat ttccgaaatg gaaggaaaag gtcttagcgc
    12601 agagcaggca cagattgaag cattttacga aattaaaaga ggataggagg agagcgctat
    12661 gggaaaacca actggatttt tagaatatga acgaaaagaa agcgtgggag aagcgccgtt
    12721 aaagagaatc aaacatttta acgaatttca cactcccctg tccaaaaaag aacaggagag
    12781 acagggagca agatgtatga actgtggagt tccattttgc cagtccggta ttttgattaa
    12841 aggaatggtt accggatgcc cgcttaataa tctgattcct gaatggaatg atgcaactta
    12901 cacaggtaac tgggatgaag cttataaccg tcttagaaag acaaatccat ttccagaatt
    12961 tacaggtcgt gtatgtccac atccttgtga agtcggatgt acctgtaact taggcgggga
    13021 tccggttaac atcaaagaaa aagagttaag tattatagag cgagcttatg aaagtggcct
    13081 gatcaaaccg gaaccaccag aagtccgcac aggaaagaca gttgctatcg taggttccgg
    13141 tccatccgga ctctgcgtgg cagaatactt aaaccgccgt ggccattctg taactgttta
    13201 cgagcgttcc gaccgtgttg gtggactgct catgtacgga attcctaaca tgaagcttga
    13261 aaaaacatat attgagagaa aagtaaagct catggaaaaa gaaggcgttg tattcaagac
    13321 aggcgtaaac gttggtgtag acgtaaaagc acaggactta aagaaacagt atgatgctgt
    13381 tgtactttgc tgtggagcct ctaatccaag agacatcaaa gcaccaggca gaaagagcaa
    13441 aggaatttat tttgcagtag attacttaaa ggcagcaaca aagagccttt tagattctaa
    13501 cttcgcagat aaaaaataca ttgatgccaa agataaaaat gtaatggtta tcggtggcgg
    13561 tgacacagga aatgactgtg ttggaacatc catccgttta ggatgtaaga gcctcattca
    13621 gttagaaatg atgccaaaac ttccagatga acgtcagcca aataacccat ggccagaatg
    13681 gcctagagtc tgcaagacag actacggtca ggaagaagct atcgctgtat ttggcaaaga
    13741 cccacgagta tatcagacaa ccgtaaaaga attcattgcc aatgaaaaag gcgaagtctg
    13801 caaggcaaaa ctcgtaaaac ttgaaagtaa attcgacaaa aaagccggaa gaaatatcat
    13861 ggcagaagtc gctggcagcg agtatgaagt acctgttgat ttggtattaa tcgcagcagg
    13921 attcttagga agccagccat atgttacaaa agcttttggc ttagatctta cagaacgcac
    13981 gaatgtaaag acagtagaag gacatttcaa gacaaatgta gataaagtct ttactgccgg
    14041 tgatatgcat cgaggacagt cacttgttgt atgggcaatt cgcgaaggtc gggactgtgc
    14101 aagagaagtt gataaagccc tgatgggata ctcaaatctg taacttctgg tttgccgcag
    14161 gcaaagagac gctcgcagta aataaaagaa cctatatttg tgact
//
