LOCUS       gnlProkkaALEKFNDC_48   12373 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ALEKFNDC_48.
ACCESSION   gnlProkkaALEKFNDC_48
VERSION     gnlProkkaALEKFNDC_48
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 22:56:43
            Original ID  :: gnl|Prokka|ALEKFNDC_48
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 10250
            Orig. end    :: 22623
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12373
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10198]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10198
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12373
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12373
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             1023..2141
                     /locus_tag="ctg48_14"
                     /transl_table=11
                     /translation="MARRRKNEKRQKSIRYFDYSLLFLIIFLLCFGLIMLYSTSSYYGS
                     TRFNDAAYYVKRQMYASALGIVAMLFISRIPYKFWMQLSTLAYFVALVLCTAVIFVGTS
                     AKGQSRWLRIGPIQFQPSEIAKIAVIIFLATIIYKTPKRIGEIMSLLKIMLLISPVLAV
                     VAYNNLSTAIIILGIAVCMLFVASPKYLQFILMGIGVCLFGALFILLASYRAERVMIWL
                     HPEDYEKGYQTLQGLYAIGSGGLFGKGLGESMQKLGFIPEAQNDMIFSVICEELGLFGA
                     VCLILLYLLIIWRLMIIANNASDLYGALIVVGIMAHLSIQVLLNIAVVTNTIPNTGVSL
                     PFISYGGTSISILLAEMGLALSVSRGIKLEVA"
     CDS             2144..2899
                     /locus_tag="ctg48_15"
                     /transl_table=11
                     /translation="MRIKEQRKRKKRRRIGICIFLVVLMLFALAALIVVKVFTVQNVVV
                     EGNSLYSADQIKNMVLDDDYSWNSLYVDLKYRFVDVGEVPFVDTMEISLDDPHTLRISV
                     TEKGILGSFYIDTLGQYAYFDKDGFVVETSSDVIEGVPKITGVTCDSVVLYEKLPLEDT
                     KLLRNLLTLTQLLKKYELEPEEIHYDSAMQPQLTYGTIAVNVGSEDYLTQKIARLSAIM
                     PQLSGLSGILHLETWTPDTTDIVFDRADL"
     CDS             3016..4212
                     /locus_tag="ctg48_16"
                     /transl_table=11
                     /translation="MLEIKTTEADTSAKIIVIGVGGAGNNAVNRMIDESIGGVEFIGVN
                     TDKQALALCKAPTLIQIGEKLTKGLGAGAQPEIGQKAAEESMEELSAAVKGADMVFVTC
                     GMGGGTGTGAAPVVAKIAKEQGILTVGVVTKPFKFEAKQRMLNALSGIDRLKESVDTLI
                     VIPNDKLLEIVDRRTTMPDALKKADEVLQQAVQGITDLINLPALINLDFADVSTVMKDK
                     GMAHIGIGNAKGDDKAIEAVKLAVASPLLETTINGASHVIINISGDISLMDANDAASYV
                     QDLAGDNANIIFGAKYDESMTDEATITVIATGLENAAAPKSKIMPDLRYGNTTNVTRPV
                     GTPGINRQAANLGASVQAHTQTQTAAPSFSGIQRPRQPESTVQPMDIKIPDFLKNSRK"
     CDS             4609..5292
                     /locus_tag="ctg48_17"
                     /transl_table=11
                     /translation="MFSLIHLFLVCFINNRILYFLIAHFVLNTGMVFFCFGWEGKRSYL
                     ENWVVTYFMCVIQGGALEWLLEQHIFSQNEILQMLVAAAVVVTAVICFGERRVCGNHIY
                     PAELKKGERYIRLRAYWDSGNQLTDPYTGQEISILSGSVAEKFFTKEKDLVRFVPYRSL
                     GEKDGLIAVTNVDEMTVFQGKRAVKIPHAAIGTADKMLFDGKEYEMLLNASSIMPQGGK
                     TENKN"
     CDS             5243..6037
                     /locus_tag="ctg48_18"
                     /transl_table=11
                     /translation="MLRALCHKAARQKIRIKVELKMYIKFAIPKIRTMIFPGIFRKKKD
                     EVHYIGGAEVLPPPLAGEDEAVCIEMLTSDESGQIARKRLIEHNLRLVVYIAKKFDNTG
                     VGVEDLISIGTIGLIKAINTFNSGKNIKLATYASRCIENEILMYLRRNSKTRMEVSIDE
                     PLNVDWDGNELLLSDILGTDEDVIYHDIETDVEHRLLKTAIGKLSGRERMIIELRFGLN
                     SIDGEEKTQKEVADMLGISQSYISRLEKKIMGRLKKEIVRLE"
     CDS             6165..7775
                     /locus_tag="ctg48_19"
                     /transl_table=11
                     /translation="MVLEFLGAAHEVTGSCHYLSFGDKHILVDCGMEQGPDLYTNQEIP
                     VNAAMIDYVFVTHAHIDHSGLLPLLYNHGFRGKIYCTLATNELCNIMLKDSAHIQMFEA
                     EWRNRKAKRAGKPEVVPLYDMNDAMSVLSHFVPCDYQKKIKVCDGLEIRFVDAGHLLGS
                     SSIEMWVRDDDGTEVKLAFSGDIGPGNRPLIKDPEYIKDADYVIMESTYGDRKHNTPPD
                     FAIALAKVIKETLYERGGNLVVPAFSVGRTQEMLYFIRRIKSEHLLPEFENFEVYIDSP
                     LAVEATSIFNKSVEECFDEDARALVQQGINPIGFPGLKMAITSDESKMINFNDNPKVII
                     SASGMCEAGRIRHHLKHNLWRKDSTILFVGYQVPGTLGFSLLNGAKEVRLFGETIEVAA
                     RIENLPGISGHADVEQLTKWAAAFENKPKKVFVVHGEDKVTEQFADHLKDTLGYEAYAP
                     FPGDAFDLATGEQVREGSRERAEKKITEKSRASSNVFARLLAAGQRLLTVINKCEGMPN
                     KELGKFADQINALCNKWDR"
     CDS             complement(7772..8002)
                     /locus_tag="ctg48_20"
                     /transl_table=11
                     /translation="MDQISDKKNREENWIEELSLNDALDRLNERENYILKLRFFEGKTQ
                     MEVADEIHISQAQVSRLEKSALKSIRHYLSL"
     CDS             8171..8401
                     /locus_tag="ctg48_21"
                     /transl_table=11
                     /translation="MDCLVGSVAQGTADADRVIVAQVTSYLTYNHGNCVSGKLNPDRRI
                     EVVDGLDQADTADLKQIIYIFVIAGKTFDDT"
     CDS             complement(8355..8582)
                     /locus_tag="ctg48_22"
                     /transl_table=11
                     /translation="MLFMVKIKFRRINSMASYKVEICGVNTAKLPILKEEEKDALFARI
                     KQXXXXLYQRQSQAGIKCHQTFFRQSRKCR"
     CDS             9061..9906
                     /locus_tag="ctg48_23"
                     /transl_table=11
                     /translation="MSEIILRKYHGVGNDYLIFDPKKNDVVLNERLIRQLCRRNIGVGA
                     DGILYGPVMEDKKIKVRIFNPDGSEAEKSGNGIRIFSRYLKDAGYVKERQYYLTTKAGE
                     TLVTFLDDAGSCMRVDMGYAVFEAEQIPALGFEGEVVGESIFFCDNFYNATCVSMGNPN
                     CVIMLERVDREKALHLGPYVENAKYFPNRINMQLCQIVDEKNIQVEIYERGAGYTFASG
                     TGACAAAAASHRLGLVEDAVTVHMHGGDLFIEFEKDGRIFMTGPVVYIGKITVAEQFFA
                     "
     CDS             10001..10198
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_24"
                     /sec_met_domain="PF05402 (E-value: 1.9e-14, bitscore: 44.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.3e-10,
                     bitscore: 32.0, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQGEQYKKPFMLNECGAYIYRAYISGMSEDEITQAFAKEYGLSF
                     SCAQSDVGQFMMELRQQGII"
     CDS             10212..12371
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 79.5;
                     E-value: 4.8e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_25"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.3e-20, bitscore:
                     62.6, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNILLVGNAGNFMRLMINRLNKEGHRVFVLTEEPKKGYSLKKVFE
                     VYHFSYEDACVREVLESIMPQVVVFLGAYDHNFSWNRVENTAASYAAGLTNILMNYTAL
                     KKGRFVYLSSESVFGGGSAQFMTEDDPTGAYSKKGQAIAIGEDICKNYARMGNDVVILR
                     LDHLYGEIRKKEDTDTICADMCLEAVQTGEIIASQNEKIMLLHEADAVEFIYQIMVAKD
                     HKHTLYQLSSGEKMSRYELAQAVAAGMENEVSIVEEENKKYREVMLSGKRYDEEFGSRV
                     LHHAGTDVEKIAAYFSRHVSEFTDAGQKKGHLFRRLGSRTKEIITNLIPFMENLICFIP
                     FFMLNNRAVGSEYFQNIDFYLLYVLLFALVYGQQQATFSALLAVAGYCFRQMYHRSGFD
                     VMLDYNTYVWIAQLLILGLAVGYLRDQLRAMREEQRHEVSYLTKQLDDISDINVSNVRV
                     KEILANQIVNQNDSFGKLYEITSSLEQYEPCEVLFYAAEVLAKLMGSKDVAIYTVANRS
                     YARLFSATSEKARSLGNSINYSEMDAMYTVLAGKKVYINKNMDERYPLMANAIYSEDEM
                     QLILMIWGIPWERMTLGQANMLTVIGYLIQNAVVRANRYISALEQQRYIKGTNILEPEA
                     FLALVKAYLNARDKGLTQCALLSVDTKENDRDEVGKRLIKLLRQSDYVGELEGGKMYAL
                     LANTSAKDATMVKERFEKEGVSCQIQ"
ORIGIN
        1 aaaaaatgtt atccggaagt ctttgtggtt ggaaatattg gtattcctta tacttcaatt
       61 gtggagaaaa ctacagagca gaccgtcaca gtgacagaga tcagcagttt ccagttagaa
      121 acgatggaaa catttcatcc gtctgtttct gcaattttaa atattacgcc ggatcatctt
      181 gacagacatc acacgatgga ggcgtatatc cgtgcaaagg agagcattac aaagtgtcag
      241 acaaaggaag atacctgtgt gctcaactat gaggatgaaa tacttcggaa atttgccgaa
      301 acattaaaag taaacgtttt gtttttcagc agtaaaagac cattggaaga gggaatttat
      361 ctgcaggaaa atacgatctg gatcgctgga aaagaaacag aacggcagcg cctgattgat
      421 gtcggtgaat taaaacttct gggcatacat aattatgaaa atgttatggc agcttccggc
      481 actgcacttt gtatgggagc accgatagat gttgtgcagc gtgtactaaa agagttttgg
      541 ggtgtaaaac accgcattga gtttgtgaga gatctgcatg gtgttttgta ctataacgat
      601 tctaaggcga caaatccgga tgcggcaatc cgcgggatcg gttcaatgaa tcgtaagaca
      661 ctgctgatcg gcggcggtta tgataaaaat cttgaatttg atgcgtggat tgagagcttt
      721 gatgggaaag taaaatgtct attactgatc ggacagacaa aagataagat cgcagtctgc
      781 gcaaggaaac atggttttga gaatattgta tgctgtgata cattaaatga agcggtaaat
      841 atctgttata ggctggcaaa gcccggggaa gcagtattgc tttcaccggc atgtgcgagc
      901 tggggagatt ttaaggatta tacacagcgg ggagaactgt tccggcaata tgtcatggaa
      961 ctgccggaat aaaacggttg tggtgcttga tcagacaggt tttgtgtaaa tgaggaaaaa
     1021 ttatggcaag aagacggaaa aatgaaaaaa gacaaaaatc gatccggtat tttgattaca
     1081 gcctgttatt tctgattata tttttgttat gtttcggact gattatgtta tatagtacca
     1141 gttcctacta tggctcaaca agatttaacg atgcagcata ttatgtaaaa agacaaatgt
     1201 atgcaagtgc acttggaata gtggcaatgc tttttatttc aagaatccca tataagttct
     1261 ggatgcagct ttcaacgctt gcgtattttg tggcgctggt actttgtaca gcggttattt
     1321 ttgtcggaac aagtgcaaag ggacagtcga gatggctcag gatcggaccg atccagttcc
     1381 agccatctga gatcgcaaaa attgcggtta tcattttcct tgcgacgatc atctataaaa
     1441 cgcctaaacg cattggggaa attatgagtc tgcttaagat catgcttttg atttcaccgg
     1501 ttttggcagt ggttgcgtat aataacttaa gtacggcgat cattatcctt ggaattgctg
     1561 tctgtatgtt atttgttgcg agtccgaaat atttacagtt tattttaatg ggaataggag
     1621 tatgcctttt tggtgctctg tttattctgc tggcgtctta ccgtgcggaa cgtgttatga
     1681 tctggctgca cccggaggat tatgaaaaag ggtatcagac gctgcaggga ttatatgcga
     1741 tcggttcggg aggccttttc ggaaaagggt taggagagag catgcagaaa ctgggattta
     1801 tcccggaggc acaaaatgat atgatctttt cggttatctg tgaagaactt ggactttttg
     1861 gtgcagtctg tctgatactt ttgtatctgc ttattatctg gcgtctgatg atcattgcaa
     1921 acaatgcatc cgatctgtat ggcgcattga tcgtagttgg tattatggca catttgtcca
     1981 ttcaggtact gcttaatatt gcggttgtaa caaatacaat accgaatacg ggagtatcac
     2041 tgccgtttat cagttatgga ggaacatcca tatcgatttt gctggctgag atggggctgg
     2101 cactttctgt atcgagggga attaaattag aggttgcctg attatgagga tcaaagaaca
     2161 gagaaaaaga aaaaaaagaa gaagaatcgg gatctgtatc tttctggtag ttctgatgtt
     2221 gtttgcactt gcggcactta ttgtggtaaa ggtatttaca gtccagaatg tagttgtgga
     2281 aggaaacagt ctttattctg ccgaccagat caaaaatatg gtgctggacg atgattattc
     2341 gtggaacagt ctgtatgtag atctgaaata ccggtttgtg gatgtcgggg aagtaccgtt
     2401 tgtggatacg atggaaattt cgctggatga tccgcataca ttgcggattt cggttacaga
     2461 aaaaggtatt ctgggcagtt tttatattga tacgcttgga caatatgcgt actttgataa
     2521 agacggattt gttgtggaaa cttcgtcgga tgtaatcgaa ggagtgccaa agatcacggg
     2581 agttacctgt gatagtgtgg ttttatacga aaaactgccg cttgaggata caaaactgct
     2641 gagaaatctg ttgacactga cacaactact gaaaaaatat gaacttgaac cggaagaaat
     2701 ccactatgac agtgcaatgc agccacagct cacttacgga acgattgcgg tcaatgttgg
     2761 ttcagaagat tatctgacac agaaaattgc gagactttcc gcaattatgc cacagttgtc
     2821 gggactctcc ggtatactgc atttagagac atggacgccg gatacgacag atattgtgtt
     2881 tgaccgtgca gatttgtaaa aaaaaagtgt aatctttttt gaaaaatcag ttgattaatt
     2941 gtaagaaaaa ttatattata gattatatga gttttttagc tgtaattttt taagctaaat
     3001 gaaggaggaa ctaccttgct ggagattaag acaacagaag cggataccag tgcaaagatc
     3061 atcgtgatcg gagtaggagg agctggtaat aatgctgtaa atagaatgat tgatgagagt
     3121 atcgggggag tcgagtttat cggagtaaat acagataaac aggcgttggc actctgtaaa
     3181 gcaccgacac tgatccagat cggtgaaaag ctgacaaaag gacttggagc aggagcacag
     3241 ccggaaatcg gtcagaaagc cgctgaggaa agcatggaag aattatctgc agcagtgaag
     3301 ggcgcggata tggttttcgt aacctgtggt atgggtggcg gaaccggaac aggtgcagca
     3361 ccggttgttg caaagattgc aaaagagcag ggaatcttaa cggtcggcgt tgtgacaaaa
     3421 ccattcaaat ttgaagcaaa acagcgtatg ttaaatgcac tttccggtat tgaccgttta
     3481 aaagagagcg ttgatacact gatcgtgatc ccgaatgata agcttctgga gatcgttgac
     3541 agacgtacga ccatgccgga tgccttaaag aaggcagatg aagtgttaca gcaggctgtt
     3601 cagggaatta cagaccttat caatctgccg gcactgatca atcttgactt tgctgatgtt
     3661 tccactgtca tgaaggacaa gggtatggca catatcggta tcggtaatgc caagggagat
     3721 gacaaagcaa tcgaagctgt caaacttgca gttgcgagtc cgctgttaga gaccacgatc
     3781 aatggtgcat cccatgttat tatcaatatt tccggtgata tttccctgat ggatgcgaac
     3841 gatgcagcaa gctatgttca ggatcttgca ggtgataatg caaacattat ttttggtgcg
     3901 aagtatgatg agtctatgac agatgaagct acgatcacag ttatcgcaac aggacttgag
     3961 aatgcggcag caccgaagag caagattatg ccggatctcc gctatggaaa tacaacaaac
     4021 gttacaagac cggttggaac acctggcatc aacagacagg cggcaaatct tggtgcaagt
     4081 gtacaggcac atacgcagac acagacggct gcaccatcat tttctggtat tcagagaccg
     4141 cgtcagcctg agagcacagt acagccaatg gatattaaaa ttccggattt ccttaaaaat
     4201 tcaagaaaat aatatctgag ataaaatatt agaaaacata acaacagata tgcctgcaaa
     4261 gtacgcgggc tgcagcagca gtttatacat ctgaaaagag atttatgtgt ttgaagagaa
     4321 aacacataaa tctcttttta tatatagaaa agaacaacgc ttgtcgaaaa taagggatga
     4381 tttgcgggat ttggagtacc tgttttgaca aaaagtaaag ttgtactgtt ttataataac
     4441 agtaaagata cgaaagagtc tggagaaaag gggtgagacg agatctatgt attttatgca
     4501 gatgtgttcc tgcttgaaaa tctgtttatg gactatatgg caatacttgg atgcaactgc
     4561 ctgctgaaac ggaggataca tcccgggcgg ctgtttgcgg tatcgctgat gttttcgctg
     4621 attcatctgt ttctggtgtg ctttatcaat aacaggatcc tgtatttttt gatcgcacat
     4681 tttgttttaa acacagggat ggtatttttt tgttttggtt gggaaggaaa acgcagttat
     4741 ttagaaaact gggttgtgac ctattttatg tgcgtgatac agggaggtgc gcttgagtgg
     4801 cttttagaac agcatatatt ttcgcaaaat gaaattttac agatgcttgt tgcggcagcg
     4861 gtagttgtta cggcagtgat ctgttttggt gaaaggcgcg tttgtggaaa tcatatttat
     4921 cctgcagagt taaaaaaagg agaaaggtat atcagactgc gtgcatactg ggatagcggg
     4981 aatcagctga cggatccgta cacaggacag gagatcagta ttctatcagg atctgtggcg
     5041 gaaaaattct ttacaaaaga aaaggatctg gttcgttttg tgccatatcg atcactgggg
     5101 gaaaaggatg gactgatcgc ggtaacaaat gtggatgaaa tgactgtttt tcagggaaaa
     5161 cgtgcggtaa aaatcccaca tgcagcgatt ggaaccgcag ataagatgct gtttgacggt
     5221 aaggaatatg aaatgctctt aaatgcttcg agcattatgc cacaaggcgg caagacagaa
     5281 aataagaatt aaggtggaat tgaaaatgta cataaaattt gcgataccaa agataagaac
     5341 gatgatattt cccggtattt ttcgaaagaa aaaggatgag gtgcattata tcggaggcgc
     5401 agaggtactt ccgccgccgc ttgccggtga agatgaggcg gtatgcatag agatgcttac
     5461 cagtgatgaa agcggacaga ttgcaagaaa acggctgatt gaacataact tgcggcttgt
     5521 ggtgtatatt gcaaaaaaat ttgataatac cggcgtcggg gtggaggatc tgatttctat
     5581 cggtacgatc ggtctgatca aagcaatcaa cacatttaat tccgggaaaa atatcaaact
     5641 tgcgacctac gcttcgagat gcattgaaaa tgaaattctg atgtatctgc ggcgaaacag
     5701 caaaacgaga atggaagtgt ctattgatga gcctttaaac gtggactggg acggaaatga
     5761 gctgttactt tcggatatct taggaaccga tgaggacgtg atctatcacg acattgaaac
     5821 ggatgtggaa catcggctgc ttaagacagc gattggaaaa ctatctggca gggaacggat
     5881 gatcattgaa ctgcggtttg ggttaaattc catcgatgga gaggaaaaaa cccagaaaga
     5941 ggttgcggat atgcttggta tttcccagtc ctacatatcc agactggaaa aaaagatcat
     6001 gggaagactg aaaaaagaaa tcgtgcgtct tgagtaaagt ctctctgttt ttgtctggta
     6061 aaatgacaaa atagttaaaa aatatataaa atatgaaaaa atattgtgca tatagctgaa
     6121 aaatagtata atgaaagaaa agcagacaga atgggggact tcatatggta ttggaatttt
     6181 taggcgcagc acatgaggta acaggcagtt gtcattatct atcctttgga gataagcata
     6241 tactggtgga ctgtggtatg gaacaggggc cggatctgta cacaaatcag gagattccgg
     6301 tcaatgcagc gatgatcgat tatgtatttg tgacgcatgc acatattgat cattccggat
     6361 tattgccgct tttatacaat catggtttcc gcggcaaaat atactgtacc ttagcgacca
     6421 atgaactctg caacattatg ctcaaagaca gtgcacatat ccagatgttc gaggcagaat
     6481 ggcgcaatcg taaggcaaaa cgggccggaa aaccggaagt ggtgcctctt tatgatatga
     6541 atgatgcgat gagcgtactg agccattttg tgccgtgtga ttatcagaaa aagatcaaag
     6601 tctgtgacgg acttgagatc cgttttgtag atgcaggtca tctgcttgga tcctcaagca
     6661 ttgaaatgtg ggtgagggat gatgatggta cagaggtaaa actggcattt tccggtgata
     6721 tcggaccagg taaccgtccg ctcatcaaag atccggaata catcaaagat gccgattatg
     6781 tgatcatgga gtcaacctat ggtgacagaa aacacaacac acctccggat ttcgcgatcg
     6841 ccctggcaaa agtgatcaaa gaaacattgt atgaacgcgg cggtaatctg gtcgttcctg
     6901 cattttccgt gggcagaaca caggagatgc tttattttat ccgcaggatc aagagtgagc
     6961 atctgctgcc ggaatttgaa aattttgagg tatacataga cagtccgtta gcggttgaag
     7021 cgacaagcat ttttaacaag agtgtggaag aatgttttga cgaagatgcg agagcacttg
     7081 tgcagcaggg gattaatccg atcggatttc cgggacttaa aatggcgatc acaagtgatg
     7141 agtcaaaaat gatcaacttt aatgataatc ccaaagttat tatctctgca tccggaatgt
     7201 gtgaggcggg acgtatccgc caccatttga aacataatct gtggagaaaa gattccacga
     7261 tcttattcgt gggatatcag gtgccgggaa cacttggctt ttcactctta aatggtgcaa
     7321 aagaggtaag gctctttggt gagacaatcg aggttgcggc aagaatcgag aacctgccgg
     7381 gtatcagcgg ccacgcagat gtggaacaac tgacaaaatg ggcggcagca ttcgaaaata
     7441 agccgaaaaa agtatttgtg gtacacgggg aagacaaagt tacggagcag ttcgcggatc
     7501 atttgaaaga tactttgggg tatgaggcct atgcgccgtt cccgggagat gcatttgacc
     7561 ttgcaaccgg cgagcaggta cgcgaaggat ccagagaacg ggcagagaag aagataacag
     7621 agaagagccg tgcatcgagc aatgtatttg caagactgct tgctgcaggt cagagacttc
     7681 ttacggttat caataagtgt gagggaatgc caaacaaaga acttggcaaa tttgcagatc
     7741 agatcaatgc tctgtgcaat aaatgggatc gttagagcga cagataatga cgaatggatt
     7801 ttaacgcaga tttttctaag cggctgacct gagcctggga gatatggatc tcgtcagcca
     7861 cttccatctg cgtttttcct tcaaaaaagc gaagttttaa gatataattt tcacgttcgt
     7921 ttaaccggtc gagagcatcg tttagggaca gctcttcaat ccagttttct tcccggtttt
     7981 tcttgtcact gatctggtcc atgacataga gtgtgtcacc gccatcggtg tagaccgggt
     8041 cataaagact gagaggactc tggatggcat cgagggcgaa aacgatgtcc tctttagaaa
     8101 tgccggattc ggcggcaatt tcgtcgagag tcggctcttt gttttccgtc tttgagagta
     8161 tttctttggt gtggattgcc ttgtaggcag tgtcgcgcag ggaacggctg acgcggatag
     8221 agttattgtc gcgcaggtaa cgtcttatct cacctataat catgggaact gcgtaagtgg
     8281 aaaacttaac cccgatcgtc ggatcgaagt tgtcgatgga cttgatcagg ccgatacagc
     8341 cgatctgaaa cagatcatct acattttcgt gattgccgga aaaacgtttg atgacactta
     8401 ataccagcct gagattgcct ttgatataag tnnnnnnnnn nctgtttgat ccgtgcaaac
     8461 agagcatctt tttcctcttc tttcaaaatg gggagttttg cggtgttgac gccgcagatt
     8521 tctactttat aagaagccat gctgtttatc ctccggaatt ttatctttac cataaagagc
     8581 atgcttcaaa aggatgaatt ttattcagaa attaactttt tttccaatgg gtttcgtgct
     8641 aaaataaaaa ggtatcaaaa atcagaatag agtgtggtgc agtgatgatg aaagacatga
     8701 tcgataagag aaatgaacgg gaacgtatcg caagaagtat tatcaagtac tggaatgtga
     8761 actatattcc gagaacgcag gctgatttcg ggatgcagaa gcagactgcg gaggcagaaa
     8821 atgcgcaaga ccagactatg gatccaaata tgcaggaaga ctacaataaa gcaacgaacg
     8881 catattcggg taaatatggt caggagaaag acttagacga agtgacgaaa gatcagattg
     8941 acaagatcct ccacgagaag gcggaacata ttcaccagtt gtttgaaaat gggggagtag
     9001 agtaaccatt tcctgttatt ctgcatatga tatcacaagg aaaatggcag aggaatcaag
     9061 atgtctgaga tcatacttcg caaataccat ggagttggca atgattatct gatctttgat
     9121 ccgaagaaaa atgatgtagt tttaaatgag agattgataa ggcagctttg tagacgcaat
     9181 attggtgtcg gtgcagatgg aattttgtac ggaccggtta tggaagataa aaaaattaaa
     9241 gtacgaattt ttaatccgga tggaagtgaa gctgaaaaaa gcggcaatgg catccggatt
     9301 ttttcaagat atttaaaaga tgccggatat gtaaaagaaa ggcaatatta tctgaccacg
     9361 aaagcggggg aaacactggt aacatttttg gatgatgctg gaagctgtat gcgtgtggat
     9421 atgggatatg cggtctttga ggcagaacag atcccggcac ttggatttga gggagaagtt
     9481 gtaggagaat cgatattttt ctgcgacaat ttttataatg cgacctgtgt atccatggga
     9541 aatccaaatt gtgttattat gcttgagagg gtagatcgtg agaaagcact gcatttagga
     9601 ccatatgtgg aaaatgcaaa atattttcca aaccgtatca atatgcagct ttgtcagatc
     9661 gtagatgaaa aaaatataca ggttgaaatt tatgaacgtg gggcggggta tacatttgct
     9721 tccggcaccg gagcctgtgc ggcagcagcg gcttctcacc gtctgggatt agtcgaagat
     9781 gcagtgaccg tacatatgca cggtggagat ctttttatcg aatttgaaaa ggatggaaga
     9841 attttcatga caggaccggt cgtatatata ggaaagatta ctgtggcaga acagtttttt
     9901 gcctgacaga aaacgaaagt ggcgaaaaga ggggaaataa gttacaatga aagaatggta
     9961 tcaattacgc caggcagcgg gggcatactg gcttttggat atggagcagg gggaacaata
    10021 taaaaagcca ttcatgttga acgagtgcgg tgcatatata tatcgtgcgt atatttcagg
    10081 aatgtctgag gatgagatca cgcaggcatt tgcaaaagaa tatggattgt cattctcctg
    10141 cgcacaaagc gacgtagggc agtttatgat ggagttaaga caacagggaa ttatttgaga
    10201 atggagcagg tatgaatata ttgctagttg ggaatgccgg caattttatg cggcttatga
    10261 tcaacagact gaataaggaa ggacacaggg tctttgtgct gacagaagaa ccaaagaagg
    10321 gatacagcct gaagaaagta tttgaagtgt atcatttttc gtatgaggat gcctgtgtgc
    10381 gggaggtatt agagagtatt atgccacagg tagtagtttt tctgggggca tatgaccata
    10441 atttttcctg gaacagggtg gaaaacacag cggcgtccta tgcagcggga cttacgaata
    10501 tactgatgaa ttataccgct ttaaagaaag gcaggtttgt ctatctttct tcggagagtg
    10561 tttttggcgg tggaagcgca cagtttatga cagaggatga tcctaccggg gcatacagca
    10621 agaaaggcca ggcgatcgct atcggagaag atatctgtaa aaattatgca aggatgggga
    10681 atgatgttgt gattctccgc ctcgatcatt tgtatgggga aatacgaaag aaagaggata
    10741 cagatacgat ctgtgcggat atgtgcctcg aagcagtcca gaccggagag atcattgcgt
    10801 cgcagaatga aaaaataatg cttctgcatg aggcggatgc ggtggagttt atctaccaga
    10861 taatggtggc aaaggaccat aaacataccc tctatcagtt atcttccggg gagaaaatgt
    10921 cacggtatga gcttgcccag gctgttgccg caggaatgga gaatgaggtc agtatcgtag
    10981 aagaggaaaa caaaaaatac cgggaagtta tgctttccgg taaaagatac gatgaagaat
    11041 ttggaagccg tgtgcttcat catgcaggaa cagatgtgga aaagattgcg gcttatttca
    11101 gcagacatgt atctgaattt acagatgcag ggcagaaaaa gggacatctg tttcgaagat
    11161 taggcagcag gacaaaggaa atcataacga atctgattcc ttttatggaa aacctgattt
    11221 gttttattcc gtttttcatg ttgaataacc gtgcagtcgg aagtgaatac tttcagaata
    11281 ttgattttta tcttctgtat gtgctgttgt ttgcacttgt atacgggcag cagcaggcaa
    11341 cattttctgc attgcttgcc gtggcagggt actgtttccg gcagatgtac cacagaagcg
    11401 gatttgatgt tatgcttgac tataatacct atgtctggat cgcacagctt ttgatcttag
    11461 gtctggcagt gggatatctg agagaccagc ttcgtgcaat gagggaggaa cagcggcatg
    11521 aagtatcata cttaaccaag cagttagatg atatttcgga tatcaatgtc agcaatgtca
    11581 gggtaaaaga aattctcgca aaccagatcg taaaccagaa tgacagtttt ggaaaattat
    11641 atgagatcac atccagttta gagcagtatg aaccctgtga ggtacttttt tatgcggcgg
    11701 aagtacttgc aaaactgatg ggaagcaaag atgtggcaat ctatacggtg gcaaaccgtt
    11761 cctatgcacg tcttttttct gcaacatcgg agaaagcacg cagcctcggt aattcaatca
    11821 attacagcga gatggatgcc atgtatacgg tgcttgccgg gaagaaagtt tatattaata
    11881 aaaatatgga tgaaagatat ccgcttatgg caaatgccat ttattcggaa gatgagatgc
    11941 agctgattct gatgatctgg ggaattccgt gggagcggat gacgttagga caggcgaata
    12001 tgctgacggt tatcggttat ctgattcaga atgcggtggt gcgtgcaaac cgttatattt
    12061 ctgccttaga gcagcagcgt tacataaaag gaacgaatat attagaaccg gaagcctttt
    12121 tagcacttgt aaaggcgtat ttaaatgcgc gtgataaagg attgacacag tgtgcactgc
    12181 tttccgtgga tacaaaggaa aatgaccgtg atgaggtcgg gaaaaggctt atcaaactcc
    12241 ttagacaaag cgattatgtc ggtgaacttg aaggtggaaa aatgtatgcg cttcttgcaa
    12301 ataccagtgc aaaagatgca accatggtaa aagaaagatt tgaaaaagag ggtgtgtcct
    12361 gccagataca gga
//
