LOCUS       c00007_gnlPro..        16540 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BAEMBNGD_7.
ACCESSION   c00007_gnlPro..
VERSION     c00007_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 00:32:50
            Original ID  :: gnl|Prokka|BAEMBNGD_7
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16540
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16540
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[990:6540]"
                     /cutoff="20000"
                     /detection_rule="(minimum(2, [Aldedh, BMC, Cob_adeno_trans,
                     EutN_CcmL, Fe-ADH, Fe-ADH_2, PDU_like, PTAC, PduV-EutP])
                     and Dehydratase_MU and Dehydratase_SU and Dehydratase_LU)"
                     /neighbourhood="10000"
                     /product="pdu"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      991..6540
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="20000"
                     /detection_rule="(minimum(2, [Aldedh, BMC, Cob_adeno_trans,
                     EutN_CcmL, Fe-ADH, Fe-ADH_2, PDU_like, PTAC, PduV-EutP])
                     and Dehydratase_MU and Dehydratase_SU and Dehydratase_LU)"
                     /neighbourhood="10000"
                     /product="pdu"
                     /protocluster_number="1"
     cand_cluster    1..16540
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [Aldedh, BMC,
                     Cob_adeno_trans, EutN_CcmL, Fe-ADH, Fe-ADH_2, PDU_like,
                     PTAC, PduV-EutP]) and Dehydratase_MU and Dehydratase_SU and
                     Dehydratase_LU)"
                     /kind="single"
                     /product="pdu"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16540
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="pdu"
                     /region_number="1"
                     /rules="(minimum(2, [Aldedh, BMC, Cob_adeno_trans,
                     EutN_CcmL, Fe-ADH, Fe-ADH_2, PDU_like, PTAC, PduV-EutP])
                     and Dehydratase_MU and Dehydratase_SU and Dehydratase_LU)"
                     /tool="gutsmash"
     CDS             complement(2..958)
                     /locus_tag="ctg7_1"
                     /transl_table=11
                     /translation="VKLVAGVDIGNATTETAIARIDGKNVTFLSSGITGTTGIKGTKQN
                     IHGVFQSLKNALDEVGFEISDLDEVRINEAAPVIGDVAMETITETIITESTMIGHNPNT
                     PGGVGIGVGISQRIDRLDTVKDGGDVIVVIPAEVSFEAAAALINRYNKIFNITGAIVQR
                     DDGVLINNRLEKKIPIVDEVGMIDKVPLGMLCAVEVAPVGGVVEVLSNPYGIATLFKLS
                     PEDTKQVVPIARALIGNRSAVVIKTPEGDVKERRIPAGSIEIIGAKKKVIVGVEEGAEK
                     MMEAVNSVPVIEDIKGEPGTNAGGMLEKVRQVMSNLTN"
     CDS             complement(991..1485)
                     /gene_functions="biosynthetic (rule-based-clusters) pdu:
                     Dehydratase_SU"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_2"
                     /sec_met_domain="Dehydratase_SU (E-value: 2.2e-60,
                     bitscore: 192.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VDQELLVRQIMQEVMKNMQGSAAACECESKVTVEDYPLGEKKPEL
                     IKSASGKSLNDLTLQGVIDGKLDAKDFRITKETLELQAQVAESAGRGFFATNLRRAGEL
                     IPVPDARLLEIYNALRPYRSTKAELYAIGDELINEYGATVSGNFVKEAADIYEKRNRLK
                     K"
     CDS             complement(1501..2160)
                     /gene_functions="biosynthetic (rule-based-clusters) pdu:
                     Dehydratase_MU"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_3"
                     /sec_met_domain="Dehydratase_MU (E-value: 9.6e-42,
                     bitscore: 131.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIDEKLLKSVIAEVLKEMNTADTSAASAVEGETYECPGMQITEI
                     GDAEKGTNPNEVVLGLAPAFGESQTTNIVGIPHADIVKEVMAGLEEEGVSCRIVKVYRT
                     SDVSFIAHDAAELSGSGIGIGIQSKGTTVIHQKDLPPLSNLELFPQCPLIDLETYRAIG
                     KNAAQYAKGESPNPVPVKNDQMARPKFQALSAVLHIKETEHADRDKAPKALKVVFK"
     CDS             complement(2184..3845)
                     /gene_functions="biosynthetic (rule-based-clusters) pdu:
                     Dehydratase_LU"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_4"
                     /sec_met_domain="Dehydratase_LU (E-value: 0.0, bitscore:
                     1018.4, seeds: 28, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRSKRFEYLDQRPVNQDGYAKEWPEVGFIAMNSPFDPTPSIKIVN
                     GEVVEMDGKTKDEFDMLDAFIARYAINLDFAEEAMATDSLEIARMLVDINVNRQECLKY
                     TTAVTPAKLVEIVGNLSVLEAMMGITKMRCRLKPANQCHVTNVKDNMVQIAADAAEAAV
                     RGFAEMETTVGIVRYAPFNAIAIMLGANVGRPGILTQCAVEEATELDLGMRGYTAYAET
                     VSVYGTEDVFMDGDDTPWSKAFLASCYASRGVKMRFTSGTGSEVQMGMAEGKSMLYLEA
                     RCLGVTRGAGVQGTQNGSVSCIGVPAAVPGGIRAVACENLIAAMLDLENASSNDQSFTH
                     SDLRRVARSIPQFIPGTDYICSGYSSTPNYDNMFAGSNWDADDYDDWCVIQRDLRVDAG
                     LLPAREEEVVAARNKAAKAIQALFRELGLPEITDEEVEAATYARGSQDMPDRDVVADLK
                     AATDMLDRGVTGIDFVKALYKGGFEDVAESIFNIQKAKVVGDYLHTASMLDDKFHVISA
                     VNSPNCYEGPMTGYQISPELWEKISDIRTAVDPAKL"
     CDS             complement(4187..4834)
                     /gene_functions="biosynthetic (rule-based-clusters) pdu:
                     BMC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_5"
                     /sec_met_domain="BMC (E-value: 1.3e-10, bitscore: 31.2,
                     seeds: 429, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDEMMAKIMDEVMKKMGGTEAPAQSMACEAPQGINEDLCGLTEY
                     VGTAMGHTIGLVIANLDYSVHELLKIDPKYRSIGIIADRTGAGPQIFACDEAVKATNTE
                     VCLIECPRDTEGGAGHGCLVVFGAEDVSDARRAVEVALSFVGKHFGDVYGNSAGHLEFQ
                     YTARASYCLEKAFGAVVGKAFGITVGAPSGIGIVLADTASKTATIDPXXXXW"
     CDS             complement(4878..5150)
                     /gene_functions="biosynthetic (rule-based-clusters) pdu:
                     BMC"
                     /gene_functions="encapsulation (smcogs) SMCOG1011:Bacterial
                     Microcompartment (BMC) domain (Score: 102.9; E-value:
                     2.3e-32)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_6"
                     /sec_met_domain="BMC (E-value: 5.2e-33, bitscore: 102.9,
                     seeds: 429, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKEALGMIETKGLVGAIEAADAMVKSANVTLVGYEKIGSGLVTV
                     MVRGDVGAVKASVDAGTVAADKVGTVVSSHVIPRPHTDVEKILPQ"
     CDS             complement(5386..6540)
                     /gene_functions="biosynthetic (rule-based-clusters) pdu:
                     Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:Iron-containing alcohol dehydrogenase (Score:
                     374; E-value: 2.1e-114)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_7"
                     /sec_met_domain="Fe-ADH (E-value: 4.8e-115, bitscore:
                     374.0, seeds: 219, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRFKLSTEVLFSEDAIDALLEEKDENAVLITDKFMVDSGMADMI
                     LKKLSNCKEVSVFSEVVPDPPMDLIERGIAFLQDKDCDIVVALGGGSSIDAAKAIVYMA
                     KKIEEKQNPDNQKKIKLIALPTTSGTGSEVTQFAVVTDSKTGVKIPLIDESLMPDIAIL
                     DPELVKSAPPFITADTGLDVITHALEAYVSETASDCSDCLAEKAAELAFEFLPRAYRNG
                     YDIKARDKMHRASCLAGMAFNLVNLGVNHGIAHALGAIFHIPHGRANALVLPYVIEFNA
                     DMAREGAKHSNDAAKKYQKMARIVGLPAPTPKVGVANLIAEIQRLLKYMDRPQCMSECG
                     VSVEEFNKHREEIVRRALADACTQANPRKVTAEDINKILDHIAK"
     CDS             complement(6527..7594)
                     /locus_tag="ctg7_8"
                     /transl_table=11
                     /translation="LYKILIVEDEELERTSMKIFLEENLLDVEIVGEAKSGFEAVEMID
                     SKDINLMLVDINIPGMDGMEVIKYARKKLPKAVIIITTAYDDFNIAHRAIKLKVDDFLL
                     KPIRKEVLLESVKSFASRLGEGRQTGKSNKLLSKFEMELKKCSYKASVDILREYIDQLY
                     LEEHDVNIISKRLQEVAKAVVRISEELGITDTNELVVQMEKLKIKYLLYNNKHDAYNEI
                     IKMVDILFDKMNIKGKLSEGGMKAVIDYIERNLKKGISLEDVANHVNISTYYLSKIFKK
                     EMGVNFITYVTDRKMDLAKEMLVNTDIPVLNIALDLAYNEANYFSKAFKKKTGLTPSEY
                     REKYRNRKEEENETV"
     CDS             complement(7610..8845)
                     /locus_tag="ctg7_9"
                     /transl_table=11
                     /translation="LTEKNNIYIEDVVDVKELQTLQDNWAKATDLAFVTVDCNGTPITK
                     QSNFTPFCKRLRELDAFREKCYYCDACGGRKARRIGKAYVYICHAGLIDFAIPIMIKGQ
                     YVGAFLAGQVTSTDFADLKKITTQSEDWKDNQELVELYSQVKEVSVEKIEAVAQIICDS
                     YNYSVEREYANKVNAELREKDYKLMKEEKLRIEMEKSLRDIELKALHYQINPHFLFNVL
                     NTIGRLAFFENAKMTEDVVYAFADMMRYILRKSRDPLSPLREELTHVQNYLKIQKIRLG
                     SRLQYSINISEAYYSVKLPFLSLTTLVENSIKYAVENKASGGMVEVNGIEKDGDLCIDI
                     IDNGDGMSQSKIVSVLRGDAYKDNEKGSVGLYNINSRLIHYFGNEYALSIESENKPSLG
                     TKVTIKVPLVQE"
     CDS             complement(8895..9569)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) B12-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_10"
                     /sec_met_domain="B12-binding (E-value: 4e-21, bitscore:
                     65.3, seeds: 91, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGATIDEIIDSLKRGQGKRVSDLVKMALEEGTDPQMILEDGFLAG
                     MEQVADKFRKEEVGVPEILSVTRALERGVSTLRHYSGGRAKKEIGTVIIGTVKGDLHDI
                     GKNLVKIMMESKNIRVIDLGVDVSPRRFLEEAVGSHAQIVCLSGIMPHSEEDMRAVVEE
                     FEMKGIRDQFYFMVGGYFLTERQAKAIGADCYTEDACNCXXXXAEKACRYLNKKDRRKK
                     NH"
     CDS             complement(9955..12390)
                     /locus_tag="ctg7_11"
                     /transl_table=11
                     /translation="LIKKDTFDKEKFKKELESNVRMLFRRKLEEATPQQIYQAVAYSVK
                     DDIIDNWIETHKAYEKQDKKMVYYMSMEFLMGRALGNNMINLLCYDDVRETLEELGLDL
                     NLIEDQEPDAALGNGGLGRLAACFLDSLATLGYPAYGCGIRYRYGMFKQKIENGYQVEV
                     PDNWLKYGNPFEIKRDEYAVEVKFGGYVDVEMHNGRQKFVQKGYQSVRAVPYDMPIVGY
                     GNHIVNTLRIWDAEAINNFNLDSFDKGEYQKAVEQENLARTICEVLYPNDNHMAGKELR
                     LKQQYFFISASVQRAVQKFKEKHDDIHQFPEKVVFQLNDTHPTVAVAELMRILMDEEGL
                     EWDEAWEITRKTCAYTNHTIMAEALEKWPIELFSRLLPRVYQIVEEINRRFVIEIQNKY
                     PGDQEKIRKMAILYDGQVRMAHLAIAGSYSVNGVARLHTDILKKRELKDFYEMMPEKFN
                     NKTNGITQRRFLLHGNPLLASWVTDKIGDDWITNLDHLKHLKVYVDDEKCQQEFMNIKY
                     QNKVRLAKYIKEHNGIDVDPRSIFDCQVKRLHEYKRQLMNILHVMYLYNEIKAHPDMDI
                     VPRTFIFGAKAAAGYYTAKLTIKLINAVADKINNDPSINGKIKVVFIEDYRVSNAELIF
                     AAADVSEQISTASKEASGTGNMKFMLNGALTLGTMDGANVEIVEEVGKENAFIFGLSAD
                     QVMEYEKNGNYNPRDVYNNNQDVRQVLTQLVNGFYSPENPELFRALYDALLEKDTYFTL
                     LDFDSYKEAHNRIDAAYRDEEHWARTAMLQTASAGKFSSDRTIEEYAKEMWHLEKVTL"
     CDS             complement(12572..15730)
                     /locus_tag="ctg7_12"
                     /transl_table=11
                     /translation="VYKKVSTNLNFVEREKETAQFWKDHDIFKKSIETREGDPVYTFYD
                     GPPTANGKPHIGHVLTRVIKDMIPRYRTMKGYMVPRKAGWDTHGLPVELEVEKKLGLDG
                     KEQIEEYGLDPFITQCKESVWKYKGMWEDFSKTVGFWADMDNPYVTYNDNFIESEWWAL
                     KTIWDKGLLYKGFKIVPYCPRCGTPLSSHEVAQGYKAVKERSAVVRFKVAGEDAYFLAW
                     TTTPWTLPSNVALCVNPEETYCKVKAADGYVYYMAKALLDKVLGKLGTEETPAYEILET
                     YKGTDLEYKEYVPLYEGAAKSAEKQHKKAHFVTCADYVTMSDGTGIVHIAPAFGEDDAQ
                     VGRKYDLPFVQFVDGKGNMTEDTPYAGLFVKDADPKVLVDLDKEGLLFDAPKFEHDYPF
                     CWRCDTPLIYYARESWFIKMTAVKDDLIRNNNTINWIPKSIGKGRFGDWLNNIQDWGIS
                     RNRYWGTPLNVWQCEGCGKMECIGSRQELEEKSGNPEAQTVELHRPYIDAITLTCPDCG
                     KTMKRVPEVIDCWFDSGAMPFAQHHYPFENKELFEQQFPAQFISEAVDQTRGWFYSLLA
                     ESTLLFNKAPYKNVIVLGHVQDENGQKMSKSKGNAVDPFDALEQHGADAIRWYFYSNSA
                     PWLPNRFHADAVTEGQRKFMGTLWNTYAFYVLYANIDEFDPTKYSLEYDKLSVMDKWLL
                     SRLNSCVKTVDDCLANYKIPETTKALQAFVDDMSNWYVRRSRQRFWAKGMEQDKINAYM
                     TLYTALVTFIKASAPMIPFMTEDIYQNLVKSVNPDAPESIHLCDFPAVDEAMIDEKLEQ
                     DMGEVLDIVVLGRAARNASGIKNRQPIGQMFVNGEAALTDYYKQIIEGELNVKDVIFKD
                     DVSDLTDYTFKPQMRILGPKYGKDLGKIRNILANLNGSAAKKELDANGFLTIELNDGKI
                     NLLPEELLIDMSQKEGYVSQADHGVTVVLDTNLTPALLEEGFVREIISKVQTMRKEAGF
                     EVTDHITVYEEGNDKIKEVMTKYTDEIKNDVLADDMCLDAEGGYSKEWDINGEKVRLGV
                     EKKM"
ORIGIN
        1 ggtttgtaag atttgacata acctgacgaa ctttttcaag cataccgccg gcattggtgc
       61 caggttcacc tttaatatct tcgatgactg gaacgctatt tacagcttcc atcatcttct
      121 cggctccctc ttctacgcca acgattactt ttttctttgc gcctataatc tcaatagaac
      181 cggcagggat acgtctttct tttacgtctc cttccggtgt tttaatgaca acggcagaac
      241 gatttccgat taacgcgcgg gcaatcggta caacctgttt tgtatcttcc ggggacagtt
      301 tgaataatgt tgcgatacca tatgggttag agagtacttc gacaactccg ccaacaggtg
      361 caacttctac tgcacataac attccgagag gtactttatc aatcatacct acctcatcaa
      421 cgataggaat cttcttttca agcctgttgt taatcaaaac gccatcatcg cgctggacaa
      481 tggcacctgt aatgttaaat attttgttat atcggttaat gagtgcagcg gcagcttcaa
      541 aggaaacttc tgccggaata accacaatta catctccgcc atctttgaca gtatctaatc
      601 tgtcgatgcg ctgagatatt ccaacaccaa tcccaacacc ccctggagta ttgggattgt
      661 gtccaatcat agtagattcc gtgataatag tttcggtaat agtctccata gcgacatcac
      721 cgataacggg agcggcttca ttaatacgaa cttcatcaag atcactgatt tcaaaaccaa
      781 cttcatcaag ggcattcttc agtgactgaa aaactccgtg tatgttctgt ttcgttcctt
      841 taattccagt agtacctgta ataccactcg aaaggaatgt cacattttta ccatcgattc
      901 tggcaatcgc agtttccgtt gttgcattgc caatatcaac gcccgcaact aatttcactt
      961 ctcatacctc cgtcgaaatc aatcaactaa ttattttttt aaacggttac gtttttcgta
     1021 aatgtctgca gcttctttaa cgaagttacc acttactgta gcaccgtatt cgttgattaa
     1081 ctcatcaccg attgcatata attcagcttt tgttgaacga tatggtctaa gagcgttata
     1141 aatctcaaga agtcttgcat caggtactgg gattaattca ccagctcttc ttaagttcgt
     1201 tgcgaagaat ccacgtcctg cagattcagc aacctgagcc tgtaattcca gagtttcttt
     1261 tgtgatacgg aaatcttttg catctaactt tccatcaata actccctgta aagttaaatc
     1321 atttaaagat tttccagaag cactcttgat taattctggt tttttctctc ccagtgggta
     1381 atcctcaacc gtaaccttgc tttcacattc gcaggctgcg gcagaaccct gcatgttttt
     1441 cataacttcc tgcataatct gtcttactaa taattcctga tccacgattg acacctccgt
     1501 ctatttaaat acaactttaa gagctttagg agccttatct ctgtctgcat gctctgtctc
     1561 tttgatatgc agtacagcgg ataaagcctg gaatttcggt cttgccatct ggtcattctt
     1621 tacaggtacc ggatttggtg attctccttt agcgtactga gcagcgtttt taccgattgc
     1681 tctgtatgtt tcaaggtcga tcagtgggca ctgtgggaat aactctaagt tagacagcgg
     1741 tggaaggtct ttctgatgga ttacagtagt acctttggac tgaattccaa ttccgatgcc
     1801 tgaacctgat aattcagcag catcatgagc gatgaaagat acatcggatg ttctgtaaac
     1861 tttaacgatt ctacaggaaa caccttcttc ttccagacca gccataacct cttttacaat
     1921 atctgcatga ggaataccta cgatatttgt tgtctgagat tctccaaaag caggagctaa
     1981 acctaaaaca acttcgttag gatttgtgcc tttttctgca tcaccgattt cagtaatctg
     2041 cattccaggg cactcataag tttctccctc tacagcagaa gctgcggaag tatctgcagt
     2101 attcatttct ttaagaactt cagcgataac actttttaat aatttttcat caattgccat
     2161 tatggttcac cttccttact cgattaaagc ttagccggat ctactgcagt acggatatca
     2221 gaaatcttct cccaaagttc tgggctgatc tggtaacctg tcataggtcc ttcatagcag
     2281 ttagggctgt taacagcaga aattacatgg aatttatcat caagcatgga agctgtatgt
     2341 aagtagtcac caacaacttt agctttctga atgttgaaga tagactcagc aacgtcttca
     2401 aatccaccct tgtaaagagc tttaacgaag tcgatacctg taactccacg atcaagcata
     2461 tctgtagcag ctttaaggtc agctacaacg tcacggtcag gcatatcctg tgaaccacga
     2521 gcgtatgtgg cagcttcaac ttcttcgtct gtaatttcag gtaaacctaa ttcacggaac
     2581 agtgcctgaa tagcttttgc agctttatta cgtgctgcaa caacttcttc ttctcttgca
     2641 ggaagaagac cagcatcaac tcttaagtca cgctgaatta cgcaccaatc atcataatcg
     2701 tctgcatccc agttggatcc tgcgaacatg ttatcatagt tcggtgtgga tgaatatccg
     2761 gaacagatgt agtcagttcc tggaataaac tgtggaatag aacgagcaac tctacgaaga
     2821 tcagagtgtg taaatgactg gtcattagag gaagcgttct caaggtcaag catagcggca
     2881 attaagttct cacatgcaac ggcgcggata ccaccaggta cagcggcagg tacaccgata
     2941 caggatacag aaccattctg tgttccctga acaccagcac cacgagtaac accgaggcat
     3001 ctagcctcaa ggtaaagcat agactttcct tctgccatac ccatctgaac ctctgaacca
     3061 gtaccagatg taaatctcat cttaacacca cgagatgcgt agcaggatgc taagaaagct
     3121 tttgaccaag gagtatcatc accatccatg aatacgtctt cagttccgta tacggatact
     3181 gtctcggcgt aagcggtgta acctctcata cctaagtcaa gctctgtagc ttcttctaca
     3241 gcacactgtg taaggatacc aggacgtcca acgttagcac ctaacataat agcgatagca
     3301 ttaaatggag cataacgtac aatacctact gttgtctcca tctctgcaaa tccacgtaca
     3361 gcagcttctg ctgcatctgc tgcgatctga accatgttat cctttacgtt tgtaacgtgg
     3421 cactggttag ctggttttaa acgacatctc atcttggtaa tacccatcat agcttcaagt
     3481 acgctgaggt taccaacgat ttctactaac ttagcaggtg taactgctgt agtatatttt
     3541 aagcactcct gtctgttaac attaatgtca actaacatac gcgcaatctc cagagagtct
     3601 gtagccattg cttcttctgc aaagtcaaga ttaatggcat atcttgcgat gaatgcgtca
     3661 agcatgtcga attcatcttt tgtttttcca tccatttcaa caacttcgcc gttgacgatc
     3721 ttgatagatg gagttgggtc gaatgggctg ttcatggcaa taaagcctac ttctggccat
     3781 tcctttgcat aaccatcctg attaacaggt ctttgatcta aatactcaaa acgtttactt
     3841 ctcacggtct caacacctct caaattccaa ttagactatc ttttaccttc aatatatata
     3901 ttcaaaataa aagtattaca atatccaact gcaggctctc acccccgctt tgtggatatc
     3961 tcttactcta attccctata tggctctcac cccatataaa gaactttaaa aatcagattg
     4021 ttaatcttag atatatggaa ctgtaccgga ttccagtggt tcgtttggct ctaaagcttt
     4081 aagtaactgc ttaccaactt ctcttgcacc aatgatagcc tgtctaactg ctcctgaatc
     4141 tcctgtgaag aagaagttaa cctcgttaga gaaggatgtt ccaccattac cagnnnnnnn
     4201 nnntaggatc gattgtagct gtcttagaag ctgtatcggc taatacgata ccaatacctg
     4261 aaggagctcc tacagtgata ccaaatgctt taccaacaac tgcgccgaat gctttctcta
     4321 agcagtaaga agcacgtgct gtgtactgga actcaagatg tccagcggag tttccgtata
     4381 catcaccaaa gtgttttcca acgaagctta atgcaacttc tacagctctt ctagcatcgg
     4441 atacgtcttc tgcaccaaat acaactaagc atccatgtcc agcgccgcct tctgtatcac
     4501 gtgggcactc gattaagcaa acttctgtgt ttgtagcttt aacagcttca tcacaagcga
     4561 agatctgagg acctgcacct gtacggtctg cgatgatacc gattgaacgg tacttaggat
     4621 caatctttaa taattcatga acactgtagt caaggttagc gattactaaa ccaattgtat
     4681 gtcccattgc tgttccaaca tactctgtta aaccgcaaag gtcttcattg attccctgag
     4741 gagcttcgca agccatgctc tgtgcaggag cttctgtgcc acccatcttt ttcataactt
     4801 cgtccatgat tttagccatc atttcatctt tcattgaatt atacctccat taataattga
     4861 tcagacaagg actaactcta ttgtggtaag atcttttcta cgtctgtatg tggtcttggg
     4921 attacgtggc tggaaactac tgtaccaact ttatctgcag caactgtacc tgcgtctaca
     4981 gatgccttaa cagctcctac gtcacctctt accataactg taactaaacc ggaaccgatc
     5041 ttttcgtatc ctactaatgt tacgtttgct gatttaacca tggcatcggc tgcttcgatt
     5101 gcgccaacta aacctttggt ttcaatcatt cctaaagctt ctttctgcat aattgacctc
     5161 cttataaaat tcttatctgc cctgtggttg atttgttcag gcagaatata ttttggttga
     5221 tttacaggat agtatcatta tatagcaatt ttcacaaaat tacttggcta gtgcctataa
     5281 attttagctt ttaaacacat ataaactcat gtatttattt attttcatga tactttgttg
     5341 ccatttttac cacagggtag caaatgattc tgtatacaaa cgctactatt ttgcaatatg
     5401 atcaagaatt ttattaatat cttctgctgt aacctttcta gggttagcct gtgtacatgc
     5461 atcagccaat gcacgacgca caatttcttc tctgtgttta ttaaattctt ctacactgac
     5521 gccacattcg gacatacact gtggacgatc catatatttt aacagacgct ggatctctgc
     5581 aatcagatta gccacaccaa ctttaggtgt aggagctggc aggccaacga ttcttgccat
     5641 cttctgatac ttctttgctg cgtcattgct gtgttttgcg ccttctcttg ccatatcggc
     5701 attaaattca ataacataag gaagcactaa cgcattggct cttccgtgtg gaatgtggaa
     5761 gatagctcct aaagcatggg caataccgtg gtttacacca agatttacaa ggttaaatgc
     5821 catacctgca agacaggatg ctctgtgcat cttatctctt gccttaatat cataaccatt
     5881 gcggtaagcg cgtggaagaa attcaaaagc aagctctgca gctttctctg ctaaacagtc
     5941 agagcaatcg ctcgctgtct cagaaacata agcctcaaga gcgtgggtaa taacatccag
     6001 tcctgtatcc gctgtaataa acggtggcgc tgacttaaca agttccggat caaggatagc
     6061 aatatcaggc ataaggctct catcgatcaa tggaatctta acccccgtct tactgtctgt
     6121 tactacagca aactgtgtaa cttcggaacc tgtaccactt gttgtcggca gggcaatcag
     6181 tttgatcttc ttctgattat caggattctg cttctcttca atcttcttag ccatatatac
     6241 aatagctttc gccgcgtcaa tggaagaacc tcctccaaga gcaactacga tatcacagtc
     6301 cttatcctgc aaaaatgcga tacccctttc aatcagatcc attggtggat cagggactac
     6361 ttcgctgaaa acggaaactt ctttgcaatt agacaatttt ttcaaaatca tgtctgccat
     6421 tcctgaatct accatgaact tgtcagtaat caggaccgca ttctcgtctt tttcttcaag
     6481 aagtgcgtcg atggcatcct cactgaataa aacttcagtg gaaagtttaa accgtttcat
     6541 tttcctcctc ctttctgttt ctgtactttt ctctatactc agatggcgtt aatccagtct
     6601 tctttttgaa ggccttactg aagtaattcg cttcattgta cgccagatcc aaggcaatat
     6661 taagcaccgg aatatctgtg ttgaccagca tttcttttgc caggtccatc ttccggtctg
     6721 tcacataggt gatgaaattc acacccattt cttttttgaa tatcttactt aaataataag
     6781 tactgatatt cacatggttt gcaacatcct ctaaactgat acccttcttt aagtttctct
     6841 ctatgtaatc aataacggcc ttcatgccgc cttctgaaag cttacctttg atattcatct
     6901 tatcaaagag aatgtctacc atcttgataa tttcattata ggcatcatgc ttattattat
     6961 agagaagata cttaatctta agcttctcca tctgaactac aagttcgttc gtatctgtga
     7021 ttccaagttc ctcactaata cgcacaactg cctttgcaac ctcctgtagt ctctttgata
     7081 taatattaac atcatgctcc tctaagtata actggtctat gtactctctt aaaatgtcta
     7141 cagaagcttt gtaagagcat ttttttaatt ccatttcgaa ctttgaaagc aatttattac
     7201 tctttccggt ctgtcgtccc tctcctaaac ggcttgcaaa tgacttcaca gactcaagta
     7261 aaacctcttt tctgataggt ttgagcagga aatcatcaac cttcaacttt attgctctgt
     7321 gtgcaatatt aaaatcatca tatgccgttg ttataataat aacagccttc ggaagttttt
     7381 tccttgcata tttgataact tccataccat ccattccagg tatgttaata tctaccagca
     7441 tgagattgat atcttttgaa tcaatcatct ctactgcctc gaagccgctt ttcgcttctc
     7501 cgacaatttc tacatccaga agattctcct caagaaaaat cttcatggag gttctttcta
     7561 attcttcatc ctcaacaatt aatatcttat acaagtcaac tctgcctttc tattcctgta
     7621 ccaatggcac ttttattgtc accttcgttc caagagaagg tttattttca ctttcaatgg
     7681 ataacgcata ttcatttcca aaataatgaa tcagtcggga attgatatta taaagtccta
     7741 cagatccctt ttcattatct ttatacgcat ccccgcgtaa aacgctgact atttttgact
     7801 gggacatgcc atcaccatta tcaataatgt caatgcataa atctccatct ttctcgattc
     7861 cattcacttc gaccattcca ccggatgcct tattctcaac tgcatattta atggaattct
     7921 ccacaagtgt tgtcagagat aaaaacggaa gcttcacact gtaatatgcc tccgatatat
     7981 taatggaata ctgcagccta cttcccaggc gaatcttctg aatcttaaga taattctgca
     8041 catgggtcag ttcctctctg agtgggctta atggatctct gctctttctc aaaatgtagc
     8101 gcatcatatc cgcaaacgca tagacaacat cctccgtcat cttcgcattc tcaaagaaag
     8161 caagtcttcc tattgtattc aatacattaa aaagaaaatg cggattgatc tgataatgta
     8221 aagctttcaa ctcaatatca cgaagagact tctccatctc aatacgaagc ttctcttcct
     8281 tcatgagctt ataatccttt tcgcgaagct ctgcatttac cttattcgca tattctctct
     8341 ccacagaata attatagctg tcacagataa tctgtgccac agcctcaatc ttctccacag
     8401 acacctcttt tacctggctg tagagctcaa ccagttcctg attgtccttc caatcctcgc
     8461 tttgtgtcgt aatcttcttt aaatctgcaa aatctgtgct ggtaacctga cctgccagaa
     8521 acgctccaac atactgtccc tttatcataa tcggaatcgc aaaatcaatt agcccagcat
     8581 gacatatgta cacataagct ttcccaattc ttcttgcctt ccgtcctcca caggcatcac
     8641 agtaatagca cttttcacga aatgcatcca gttcacgaag acgcttgcaa aaaggtgtaa
     8701 aattactctg ctttgtaatc ggagttccgt tgcaatccac cgtcacaaat gccagatctg
     8761 tagccttcgc ccaattatcc tgtaaagttt gaagttcttt tacatccacc acgtcttcaa
     8821 tataaatatt attcttttcc gtcaatcttc tgtcctccaa acatcggcat tatcccaacc
     8881 tcatcggtca gaaattaatg gtttttcttc cttctatctt ttttattcaa atagcggcag
     8941 gccttctctg cacnnnnnnn nnnacaatta caggcatctt ccgtataaca gtctgcaccg
     9001 attgcctttg cctgcctctc cgtcagaaaa taaccaccta ccataaaata aaactgatcc
     9061 cggatacctt tcatctcaaa ttcttcaaca acagctctca tatcttcttc agaatgcggc
     9121 atgataccac ttaaacatac aatctgagca tgactgccta ctgcctcctc cagaaatctt
     9181 ctcggtgaaa catccacgcc cagatcaata acccttatat tcttactctc catcataatc
     9241 ttaacaagat tctttccgat gtcatgtaag tcccctttta ctgttcctat tataactgtc
     9301 ccaatctcct ttttggcacg tccgccactg taatggcgca gagtagaaac gcccctttcc
     9361 aatgcgcggg taacgctcaa aatctctggc acaccaactt cttctttacg aaacttgtcc
     9421 gctacctgtt ccattccggc taaaaagcca tcttccagaa tcatctgcgg gtctgttccc
     9481 tcttctaaag ccatcttgac caagtctgag actctttttc cctgtcccct tttcagggaa
     9541 tcaataattt catctattgt tgctcccatt ttgccctcca aaaatctatc agagtgttct
     9601 atggctttat tttatacttt ttacacctaa aaagcaaatt attatcgtat attttgcaaa
     9661 ttacttttct taaatataaa attttactaa tttacagccc aaaatgataa attattttat
     9721 tcaaacgggc aagaaaaaag gtaaaaaaag gaattgggtg aaccaataac aattttttct
     9781 gatttgggct tgcaaaaaac agaacctcaa aatagaatag accccatata tgtggcctgg
     9841 gagcaagtgt tgaatgcgaa cgcttaagcg aacattcaac acaccgcgac gaaagtcaca
     9901 tatatggggt ctattctatt ttggggttcg tctatttatc gtctattcaa cgaattacag
     9961 agtcactttc tccagatgcc acatctcttt tgcatactct tcgatcgtac ggtcagatga
    10021 gaacttacct gcggatgctg tctggagcat tgctgttctt gcccagtgtt cttcatcgcg
    10081 gtaagcagca tcgattctgt tatgagcttc tttgtaagaa tcgaagtcta acagtgtgaa
    10141 ataagtgtct ttttcaagga gtgcgtcata gagggcacgg aacagttccg gattctctgg
    10201 tgaatagaat ccatttacta actgtgtaag tacctgacga acgtcctggt tgttattata
    10261 tacgtctctt ggattgtagt ttccgttttt ctcatattcc attacctggt ctgcagataa
    10321 accgaagatg aaagcgtttt ctttgccaac ttcttctaca atctcaacat tagctccatc
    10381 cattgttcct aatgtgagag caccgtttaa catgaacttc atgttacctg ttcctgatgc
    10441 ttccttagaa gctgtggaaa tctgctcgct gacatcggct gctgcaaaga taagctctgc
    10501 gttagatacg cggtaatctt cgatgaatac aactttgatc tttccattga tggatgggtc
    10561 gttgttaatc ttatctgcta ctgcattgat taacttgatc gtaagcttcg ctgtgtaata
    10621 accagcggct gcttttgctc cgaagataaa tgttcttgga acgatatcca tgtctggatg
    10681 tgctttgatt tcattgtaaa gatacattac atgaagaatg ttcattaact gacgtttgta
    10741 ctcatgtaat ctcttaacct ggcagtcaaa gatggaacgt gggtctacat caattccatt
    10801 atgctctttg atgtattttg caagacgtac cttgttctgg tatttgatgt tcatgaattc
    10861 ctgctggcac ttttcatcat ctacatatac ttttaaatgt ttaagatgat ctaagttagt
    10921 gatccagtca tcaccaatct tgtctgttac ccagcttgcc agtaatgggt taccatgaag
    10981 aaggaatctt ctctgtgtaa taccatttgt cttattgttg aacttctctg gcatcatctc
    11041 atagaaatct tttaactcac gtttcttaag gatgtctgtg tgaaggcggg caacaccgtt
    11101 aacagagtag cttcctgcga ttgcaaggtg agccattctt acctgtccat catagaggat
    11161 cgccatcttg cggatttttt cctgatctcc agggtatttg ttctggatct cgataacgaa
    11221 acgacggttg atttcttcta caatctggta aactctagga agtaatctgg agaaaagctc
    11281 gataggccac ttctcaagag cttctgccat aatagtatgg tttgtgtaag cacaggtctt
    11341 tcttgtgatt tcccatgctt catcccactc taaaccttct tcatccataa ggatacgcat
    11401 cagttccgca accgcaacgg tcgggtgggt atcatttaac tggaatacaa ccttctcagg
    11461 gaactggtgg atatcatcat gtttttcttt aaatttctgg acagctctct ggacactggc
    11521 agaaatgaag aaatactgct gttttaaacg aagttcctta cctgccatat ggttgtcgtt
    11581 tggatataat acttcacaga ttgttcttgc aagattttcc tgctctacag ctttctggta
    11641 ctcacctttg tcgaaggaat ctaagttgaa gttgttgatt gcttctgcat cccaaatacg
    11701 aagtgtgttt acgatatggt tgccataacc tacgattggc atatcgtatg gtacggcacg
    11761 tacactctgg tatcccttct gaacgaactt ctgtcttccg ttatgcatct caacatctac
    11821 ataaccgcca aacttaactt ctacggcata ctcatctctc ttgatttcaa aaggatttcc
    11881 gtattttaac cagttatctg ggacttctac ctgataaccg ttctcaattt tctgtttgaa
    11941 cataccataa cggtaacgga ttccgcaacc gtaagctgga tatccaagtg ttgcaagaga
    12001 atcaaggaaa caagctgcaa gacggccaag accaccgtta ccaagtgctg catctggctc
    12061 ctggtcttcg atgaggttaa ggtcaagtcc taactcctct aatgtttctc ttacatcatc
    12121 atagcaaaga aggttaatca tgttgtttcc aagagctcta cccataagga actccatgga
    12181 catgtagtaa accatcttct tgtcctgttt ttcgtatgct ttgtgtgtct cgatccagtt
    12241 gtcaataata tcgtctttta cggagtatgc aacagcctga taaatctgct gtggtgttgc
    12301 ttcttcgagt ttacgacgaa acagcatacg gacattggac tctaactctt ttttgaattt
    12361 ttctttgtcg aaagtatcct ttttaatcaa tgaactgatc ctcctaaatt atctcgtgta
    12421 atcctggaat ctttttcgtg cctgctttcg tgagaagatt tctatcagcc agcctcagat
    12481 tttgagacgt acgtagtaca ttcgccgcaa aatctgagtg cctctgatca aaaaccattc
    12541 gctaaaaaca agtgtttaaa aggttttaag attacatttt tttctcaaca cctaatctta
    12601 ctttttctcc attaatatcc cattccttgg aatatccgcc ttctgcgtct aagcacatat
    12661 cgtctgccaa tacatcattc ttgatttcat cagtgtattt ggtcatgact tctttaatct
    12721 tgtcattacc ctcttcgtat acagtaatgt ggtctgtcac ttcaaagccg gcttcttttc
    12781 tcattgtctg taccttactg atgatttctc ttacgaatcc ctcttccaaa agtgccggtg
    12841 tcagattagt gtcaagtact acggtaactc catgatctgc ctgagaaacg tatccctctt
    12901 tctgtgacat atcaattaat aactcttccg gcaataaatt gattttacca tcatttaact
    12961 ctattgtcaa aaagccattt gcgtctaatt ctttcttagc cgcacttccg ttaaggtttg
    13021 ctaaaatatt acggatcttt cctaagtctt taccgtattt tggtccaaga atacgcatct
    13081 gaggtttaaa tgtgtaatct gtgaggtcag atacatcatc cttaaaaata acgtctttta
    13141 cgttaagctc accttcgatg atctgtttgt agtaatctgt taaagcagcc tctccattta
    13201 caaacatctg gccgattggc tgacggttct tgattccgga tgcgttacgt gcagcacgtc
    13261 caagtacaac gatgtcaagt acttcaccca tatcctgctc aagtttctca tcaatcattg
    13321 cctcatccac tgctgggaaa tcacataaat ggatactttc tggtgcatct ggattaacac
    13381 tctttacaag gttctggtaa atgtcttctg tcataaatgg aatcattggt gcagaagctt
    13441 tgatgaatgt aacgagtgca gtataaagag tcatgtatgc attaatctta tcctgctcca
    13501 ttcctttagc ccagaaacgc tgacgggaac gacgtacata ccagttactc atatcatcta
    13561 caaatgcctg taatgccttt gttgtttcag gaatcttata gttggcaaga cagtcatcta
    13621 ctgtttttac gcaggagttc agtcttgata ataaccattt atccataaca gataacttgt
    13681 cgtactctaa gctgtacttc gttgggtcaa attcatcgat atttgcgtaa agtacataga
    13741 atgcataagt attccataat gtacccatga atttacgctg tccctctgtt actgcatctg
    13801 cgtggaaacg gtttggcagc caaggtgcac tgttagagta gaaataccag cggatagcat
    13861 ctgctccatg ctgctctaat gcatcaaacg gatctacggc atttccctta ctcttactca
    13921 ttttctgtcc gttttcgtcc tgtacgtggc caagaacgat tacgttctta taaggagctt
    13981 tgttaaataa cagtgtggac tctgcaagta aggaatagaa ccatcctctt gtctggtcta
    14041 ctgcctcaga aatgaactgt gcagggaact gctgctcgaa aagttcttta ttttcaaatg
    14101 gatagtgatg ctgtgcaaat ggcattgctc ctgagtcaaa ccagcagtcg ataacttctg
    14161 gcactctctt cattgtcttt ccacaatctg gacatgtcag agtgatcgca tcaatatatg
    14221 gtctgtgaag ttctacagtc tgagcttctg gatttccgct cttttcctct aattcctggc
    14281 ggcttccgat gcactccatc tttccgcagc cttcacactg ccatacgttt aatggtgttc
    14341 cccagtaacg gttacgggaa ataccccagt cctgaatgtt atttaaccag tcaccaaaac
    14401 ggcctttacc gatgctcttt ggaatccagt tgattgtgtt attgttgcga atcaagtcgt
    14461 cttttactgc tgtcatcttg atgaaccagg actctctcgc atagtagatc agcggtgtat
    14521 cacatctcca gcagaaagga taatcatgtt cgaacttagg cgcgtcgaaa agaaggcctt
    14581 ctttatctaa gtcaacaagt accttagggt ctgcatcttt tacaaataat ccagcataag
    14641 gtgtgtcttc tgtcatgtta ccctttccat ctacgaactg aacaaatgga agatcgtact
    14701 ttcttccaac ctgtgcatcg tcctcaccaa atgcaggtgc gatgtgtaca atacctgtac
    14761 catcggacat tgttacatag tcagcgcatg ttacgaaatg tgctttctta tgctgttttt
    14821 ctgcggactt tgcagcacct tcatatagtg gaacatactc tttatattca aggtctgttc
    14881 ctttgtaagt ttcaagaatc tcgtaagctg gagtttcttc tgttccaagc ttaccaagaa
    14941 ctttatccag taatgctttt gccatatagt aaacataacc gtcagcagct tttactttac
    15001 agtaagtctc ttctgggttt acacaaagag ctacgttact tggaagtgtc caaggtgttg
    15061 ttgtccatgc aaggaaatac gcatcttcac cagccacttt gaagcgaaca actgcggaac
    15121 gctcttttac tgccttatat ccctgtgcta cctcgtgaga agataaaggt gttccacaac
    15181 gagggcagta aggtacgatc ttaaatcctt tataaagaag acctttatcc cagatagtct
    15241 ttaatgccca ccattcggac tcaataaagt tgtcattata agttacatat gggttatcca
    15301 tatcagccca gaaaccaacg gtctttgaga aatcttccca cattcctttg tatttccaaa
    15361 cagattcttt acactgagtg ataaatgggt ctaaaccata ctcttcaatc tgttcttttc
    15421 cgtcaaggcc aagcttcttc tctacttcaa gctctactgg aagtccgtga gtatcccatc
    15481 cggcctttct tggaaccatg taacccttca ttgtacggta acgaggaatc atatccttga
    15541 ttacacgagt taaaacgtgt ccgatatgag gtttaccatt ggctgttggt ggtccatcat
    15601 agaaagtgta aacagggtca ccttctcttg tttcgatact tttcttaaaa atgtcatggt
    15661 ctttccaaaa ctgtgcagtt tctttttctc tctctacaaa attgagattc gtggatactt
    15721 tcttgtacac gacgtttcct ccttaattta gtcagtttaa tttaactact tttagattaa
    15781 ataaatttat attgtgatgt tatggccaaa agatattttg cccctaactt gatgtcacga
    15841 attactccgc agctaacgct gctcccataa ttctgaaaca tcatattatt atgcccgatg
    15901 tgcagaccaa attttccggc aaaaaaagaa aagcccccat ccccagtaaa aggatgaaag
    15961 cctgaactat cattatacca cctgtacata ctgacatatg cttctctgtt aacggtgaga
    16021 ttccgtcact gcttactgtg acctttcggc agtgcaactc aggagtgata ttcggatatt
    16081 ctctactgac aacggattcc cactatctcc gtctcactga agcgttcaaa aattcttact
    16141 gtctccatca acgtttttat cacagataat catatactag gtgggataaa ttgtcaacag
    16201 attttcattc tgtatttact gtatttatca ctatattgat tcctgtacta tttatatcag
    16261 atgtgagatg actcccacat catagcaaga atgccaggac attcttgaat tgataaaatg
    16321 tcaccagtta cttttataca ttatttatac aatgagattt cccagtttca caaaacattg
    16381 ttaatcctta aattttcttt taatttacaa aagattatgc tacaatactc cttaattaga
    16441 aaggagccta taatgttaaa aaaactcatt gtatcttttc tttgtgcgat tgttgtcgcc
    16501 tgcacagttc tcggcggatt ttgcctgctt tactttacta
//
