LOCUS       c00034_gnlPro..        12562 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HDAEJHAN_34.
ACCESSION   c00034_gnlPro..
VERSION     c00034_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 02:58:43
            Original ID  :: gnl|Prokka|HDAEJHAN_34
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12562
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12562
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4107:12494]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4108..12494
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..12562
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12562
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             207..1205
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SBP_bac_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1044:Bacterial extracellular solute-binding protein
                     (Score: 57.1; E-value: 9.5e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_1"
                     /sec_met_domain="SBP_bac_1 (E-value: 1.8e-18, bitscore:
                     57.1, seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKLFAFGLAVVLALMPVQAFGKTVSITNVSYDPTREMFEQYNK
                     IFEDHWKEKTGDDVEVIQSHGGSGKQALEVANGLDADVVTLALEYDIESIENAGLIKAG
                     WKDKFDNDSSPYTSTIVFLVKKGNPRDIKDWDDLTKKGVGVVTPNPKTSGGARWNYMAA
                     WAYADKKYGGDEAQMKEFIKKLYRNVVVLDSGARGATTSFVENGQGDVLVAWENEAYLS
                     MRDYPDEYEIVTPSVSILAQPSVAVVDEVVDYRDTRDVATEYLNYLYSDEAQEIAAENY
                     FRPTNEKILKKHSDTFDLNINLANISDYGGWDKVQEKHFTDGGIFDQIYER"
     CDS             1276..2112
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 83.9; E-value: 4e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg34_2"
                     /sec_met_domain="BPD_transp_1 (E-value: 7.8e-27, bitscore:
                     83.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRNKPVIPGFGLSMGITISILSLVVLIPLASLVVYTAKLSFKD
                     FIETITRARVLASFYTSFVCAFAAAVINGIMGTILAWVLVKYDFPGKRLMDGVIELPFA
                     LPTAVAGIALTSLTSDSGIVGSFFAGFGIKIAYTRIGITVAMIFVGIPFVVRSVQPVLE
                     KMDNSYSEAAGVLGAKKTTIFWKVIFPELKPAIFAGTGLAFGRCLGEYGSVVFIAGNKP
                     YYTEITPLVIMSKLQEFDYSSATAIALVMLAVSFFILFLNSMIQQRNARILRGGNA"
     CDS             2112..2936
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 60.2; E-value: 7.4e-19)"
                     /gene_kind="transport"
                     /locus_tag="ctg34_3"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.4e-19, bitscore:
                     60.2, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNNEKTSEKITKWLLVVISVLFLAVMLLLPLITVITEALRSGWK
                     VYAAAVTDEYTIKALLLTVKATLFAVVFNTVFGVFAAWALTKFQFRGKKLLTTLIDLPV
                     TISPVIAGLIFLLIFGRQSPVYFFFMKLGIKVVFSVPGIIIATVFVTFPFISRELIPVL
                     EAEGSDEEEAAALMGAGGWTIFWKITFPHIKWALLYGVVLCTARAMGEFGAVSVLSGHL
                     RGKTNTLPLHVEILFNEFQYVPAFAVSSLLVIMAVIILVVRSLIEYKGKKEA"
     CDS             2938..3996
                     /locus_tag="ctg34_4"
                     /transl_table=11
                     /translation="MYVELKNINKTYGSYQASRNVNLGIEKGKLIGLLGPSGSGKTTIL
                     RMIAGLETPDSGEVIIDGKVVNDVPASQRGIGFVFQNYALFRYMTVYDNVAFGLKVQKA
                     DKKKIDARVRELIKLVGLEGLEKRYPSQLSGGQRQRVAFARALAPNPQVLLLDEPFAAI
                     DAKIRQELRSWLKEMIGKLGITSIFVTHDQDEAIEVADEIIITNAGRIEQKGTPIGVYR
                     NPETAFTASFFGQPSVLKNADDFHTFAQAEGADKIIVRPEFVKISKLDEVEKFKTSVSR
                     GVVEQVSFRGDNLELQVRVNNSVVTARRSLEKADIREGETVNVFLYRIFALRGDSVQLI
                     ENEAVRDDFVII"
     CDS             4108..5856
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 71.3; E-value:
                     2.7e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_5"
                     /sec_met_domain="FAD_binding_2 (E-value: 5.2e-23, bitscore:
                     71.3, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.1e-08,
                     bitscore: 24.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTERIRTDVLIIGGGTAGCFAAYVIGKKSGRKVLIAEKANIKRS
                     GCLAAGVNALNAYITEGRVPQDYVDYAKKDAHGIVREDLLLTMSERLNHVTKVMEDLGL
                     VILKDENGKYVARGNRNIKINGENMKPILAKAAAEQENVTVLNHVNITDYKTENKKVTG
                     AVGFSVNEDIFYDIDAKAVLCATGGAAGLYRPNNPGFSRHKMWYPPFNTGAGYAMGLLS
                     GAEMTTFEMRFIALRCKDTIAPTGTIAQGVGARQVNAHGDIYETKYGLTTSQRVYGTVM
                     ENREGNGPCYLRTEGISKEQEQDLYKAYLNMAPSQTLKWMEAGKGPSEENVEIEGTEPY
                     IVGGHTASGYWVDNNRATTIEGLYAAGDVAGGCPQKYVTGALAEGEIAAEAILEYLNGK
                     DDDRIAAENKEEEALERGGEQELSQTATAKKAEYESHLNASRSLMNAEQLEEAMQKIMD
                     QYAGGIGTDYRYSGMSLAKADEKIAALLPVVDTLAATDTYELMQIYELRERLIVCQAVI
                     AHLAARKETRWHSFGENTDYPQQSEEWMKYVNSRMENGEIKILYRDLITKENTGLNTAE
                     KGAGER"
     CDS             5853..6167
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_6"
                     /sec_met_domain="Fer4_9 (E-value: 1.6e-13, bitscore: 40.4,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 2.3e-09, bitscore: 26.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.3e-05, bitscore: 14.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRIQKSKCAGCGRCIEACPGNLIKKDKENKAFIRQVRDCWGCT
                     SCIKECRHDAIRFFLGADVGGRGASMVVSEKPDISTWTVEKPDGTKITIQVNKKDANKY
                     "
     CDS             6198..7316
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAPS_reduct"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_7"
                     /sec_met_domain="PAPS_reduct (E-value: 3.6e-65, bitscore:
                     208.9, seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCLKNALRKMCVTICGRFCSDEGVVVGYDNRIRTKYTAKWGVQIA
                     GMIFQTRSSVFAQVRKDSEYKQTEEDNAMSNLSHLDALEAEAIYIMREVAAECEKPVML
                     YSIGKDSSVMLHLAMKAFYPEKPPFPFLHIDTTWKFHEMIEFRDRIAKENGIDMLVYTN
                     EEGVKAGINPFDNGSAYTDIMKTQALKQALTKYGFTAAFGGGRRDEEKSRAKERIFSFR
                     NSAQAWDPKNQRPEMWKLYNTKIQKGESMRVFPISNWTEKDIWQYIQRENIEIVPLYFA
                     KERPVIYRDGNIIMVDDDRLKLRPGEKIENKKVRFRTLGCYPLTGGIESEADTLDEIID
                     ETLSAVSSERTSRVIDHEAAGSMERRKREGYF"
     CDS             7318..8958
                     /locus_tag="ctg34_8"
                     /transl_table=11
                     /translation="MKGLLKFITCGSVDDGKSTLIGHILYDAKLLYTDQEKALELDSKV
                     GSRGGAIDYSLLLDGLMAEREQGITIDVAYRYFTTDNRSFIVADTPGHEEYTRNMAVGA
                     SFADLAVILVDASQGVLVQTRRHARICALMGIRYFVFAVNKMDLIEYDEKRFRDIENQI
                     AALIEELKLANVTIIPVSATEGDNVTTKSDNMPWYKGEALLSHLETVDIKEDTEKGFYM
                     PVQRVCRPNHEFRGFQGQIENGAIRAGDLVTTLPSKEEAHVKSILVGDKEVQEAVQGQP
                     VTIQLDREVDVSRGCVLTIDSGAVLTDSVEADILWMDDNALTDGKNFFVKIGTKMIPGL
                     VTKINYSVDVNTGEKKSAYTLKKNEIASCTLEFSEKIVVDEFDRHRTLGELILIDRVTN
                     MTSACGVVRKTFVSQDRSQIGKVDEQVRAGLKGQTPVVVEFPIGKEGITLDFAEQVEKG
                     LTVLGKHTYLYHPAASENYAETVRHLKAAGLIVLLVLDENTAKDETLKTLDGFYANWQI
                     DGITVKDAIDFVKKKSAFTVQSVHDGNYI"
     CDS             9628..9882
                     /locus_tag="ctg34_9"
                     /transl_table=11
                     /translation="MRLEKVQEALKTKKIHYEYTEENGCGSIDFMFRGLRFHIWEYEDR
                     VWGAETNVFEAGRSQDIEGDYEEIISGEILSWPDMLPGM"
     CDS             9901..10752
                     /locus_tag="ctg34_10"
                     /transl_table=11
                     /translation="MIFTKKCRTGQIVLTACIVAVCMFSNVHGTEAAGPPAPKTLTVTP
                     PEKPKSIAKSKSTSTSKSKSTPKSKSALTQKPEATPIPASTPTPEQEAETDKQNPADQG
                     TLSKPDHPDTISADKLVFIGDSRTEGLRDAVNDDSIWSCLSSMGYDWMVSTGVPQVEDQ
                     IEDNTAVIILMGVNDLYHVNDYISYINSKAAEWGNRGAQTYFVSVGPVQNDPYCSNAEI
                     ESFNAAMQANLSGVTYIDVYSHLVSEGFSTVDGTHYPDSVSVDIYNYILDHLEEQRSGI
                     WG"
     CDS             10977..12494
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_11"
                     /sec_met_domain="Fer4_7 (E-value: 1.1e-11, bitscore: 35.0,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.3e-11, bitscore: 33.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.1e-06, bitscore: 16.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGLYSSKTEIRHKIFTEIARMAYEGQSPEMLEELPYKIVPGEIA
                     TYRDSIFLERAVVGERLRVAMGMSLRKVTEHAPISKGVEASVIEEKYYEPPLINVIKFA
                     CNSCPEKRVMITEGCQGCLEHPCVEVCPKKAVHMEGGRSHIDEDACIKCGKCLEACPYN
                     AIIKQERPCSKACGMNAIGSDEYGRAEIDQDKCVSCGQCLVSCPFSAIVDKGQIFQTVM
                     ALKSETPVYAIVAPAIAGQFPGMENNKIRGAFQALGFTDVREVAVGADLCTVEEAKDFL
                     EEVPEKLPFMATSCCPSWSMMAKKLFPEQAKCISMALTPMVLTARLIKQKEPNCKIVFV
                     GPCAAKKLEASRKSIRSYVDFVLTFEEVAGMFDAKGVDWKDIPEGEPLFRASADGRGFA
                     VSGGVAEAVVHAVKRIDPDREVKVMNAEGLQNCKKMLQMAKIGKYNGYLLEGMACPGGC
                     VAGAGTIQTVKKAAAALEKMKKEASFTDAYDSKYRARLESLEKFDVE"
     CDS             12433..12558
                     /locus_tag="ctg34_12"
                     /transl_table=11
                     /translation="MPMTPNTEQDWKAWRNLMWSEILTESVKSYMDCKCLNAISI"
ORIGIN
        1 aataaaaaat atgtaatttt gactgcagca ttctgtattt caggatgctg cttttttgtg
       61 ttcttatcta cacaacataa attgtactta ttttaataca ctattgacaa attctgtcat
      121 ttcttgtaat atcatataaa acatatcgaa taactatgaa aagtagagaa tgcaaaaaac
      181 tactggtact ttaaaggaga tgaaacatga tcagaaaatt atttgccttt ggtcttgcag
      241 ttgtactggc actgatgccg gtacaggctt ttggaaaaac ggtgtctatc actaatgttt
      301 cctatgatcc taccagagag atgtttgaac agtataataa aatatttgaa gaccactgga
      361 aggagaagac cggggatgat gtggaagtga tacagtccca tggcggttca gggaaacagg
      421 cacttgaggt agccaatggt ctggatgcag atgtggtaac cctggcactg gaatatgata
      481 ttgagtctat tgaaaacgca gggctgatca aggcaggatg gaaagataaa tttgataatg
      541 acagttctcc ttatacatcc actatcgtat ttctggtgaa gaaaggaaat cccagggata
      601 tcaaagactg ggacgatctg acgaaaaaag gagtgggagt agtaacacca aatccgaaaa
      661 cctccggcgg tgccagatgg aactacatgg cagcgtgggc ttacgcagat aaaaagtatg
      721 gtggcgatga agcgcagatg aaggaattta tcaagaaact ttaccggaat gtggtggttc
      781 ttgactcagg cgcaagaggc gcaacgacct ctttcgtgga gaacggacaa ggagatgtgc
      841 tggttgcgtg ggaaaatgaa gcttatctat ccatgcggga ttatccggat gagtatgaga
      901 ttgttactcc aagcgtaagc attctggcac agccttctgt ggcggtggta gatgaagtgg
      961 tggattacag agatacaaga gatgtggcaa ctgagtattt gaattatctg tattccgacg
     1021 aagcacagga gattgcagca gagaattatt tccgccccac caatgagaaa atcctgaaga
     1081 agcacagtga tacgtttgat ctgaatataa atctggcaaa tatcagtgat tatggcggat
     1141 gggataaagt gcaggagaaa catttcacag atggcggaat tttcgatcag atttatgaga
     1201 gataaaggaa gacaagatga agcaagagca taagcacaga cagaatatat gagacaggag
     1261 aggtggtaat tgattatgaa aaaaagaaat aaaccggtga ttccagggtt tgggctctcc
     1321 atgggaatta ccatttccat attgagtctg gtagttctga ttcccctggc aagcctggtg
     1381 gtctacacag cgaagctgag ttttaaagat tttatcgaaa ccatcacaag ggccagagtg
     1441 ctggcatcct tttataccag ttttgtatgt gcttttgcag cagcagtaat aaatggaatt
     1501 atgggaacta ttcttgcgtg ggtgcttgtg aaatatgatt ttccgggcaa gagacttatg
     1561 gatggggtga tcgaacttcc ctttgctctt cccacagcgg tagcaggtat tgcactgaca
     1621 tccctgacct cagattcggg aattgtcggc agcttttttg caggattcgg tatcaagatc
     1681 gcatacacaa gaataggtat tacagtggct atgatatttg taggaatacc gttcgttgtg
     1741 cgaagtgtac agccggttct ggaaaagatg gataattctt acagcgaggc agcaggagtg
     1801 ctgggagcaa agaaaacaac tatcttctgg aaggtcattt ttccggaact gaagcccgcg
     1861 atctttgcgg gaaccggact tgcgttcgga agatgtctgg gtgaatatgg aagtgttgta
     1921 tttatcgcag gaaataaacc ctattataca gaaatcacac cgctggttat tatgtcaaag
     1981 cttcaggaat ttgattattc aagtgcaacg gcaatcgcac ttgtgatgtt ggcagtttca
     2041 ttttttattc tgttccttaa cagtatgata cagcagagaa atgcaagaat tttaagagga
     2101 ggaaatgcct gatggacaac aatgaaaaga cttcggagaa aattacaaaa tggctgcttg
     2161 tcgtgatcag tgttctgttt ctggcagtca tgctccttct tcctctgatc actgtgatca
     2221 cagaagcatt gcggagcgga tggaaggtct atgcagctgc agtgacagat gagtacacca
     2281 tcaaagcact tcttcttaca gtgaaggcaa cactctttgc agttgttttt aacactgttt
     2341 ttggtgtttt tgcagcctgg gcactgacga agtttcagtt caggggtaaa aagcttctca
     2401 ctaccctgat cgaccttccg gttactattt cccctgttat tgcaggtttg atctttcttc
     2461 tgattttcgg acgacagagt cctgtttact tttttttcat gaagttaggg attaaagttg
     2521 tattctctgt accgggaatc attattgcaa ctgtatttgt aacctttcct tttatttcca
     2581 gagaactgat tccggttctg gaagcagaag gaagcgatga ggaggaagcg gcagccctga
     2641 tgggagcagg tggatggacc attttctgga agatcacatt ccctcatatc aaatgggcat
     2701 tactgtatgg agttgtgctc tgtacggcaa gagcaatggg agagtttgga gcggtatctg
     2761 tactttccgg acatttaaga ggaaagacca atacacttcc tcttcatgta gagattttgt
     2821 ttaatgagtt tcagtatgtt ccggcgtttg ccgtatcttc gctgcttgtg atcatggcag
     2881 ttatcattct ggtagtcaga agcctgattg aatataaagg aaagaaggaa gcctgatatg
     2941 tatgtagagt taaaaaatat caataagaca tatggttctt accaggcatc aaggaatgtg
     3001 aatctcggaa ttgagaaagg taaactgatt ggtctgttgg gaccaagcgg aagcggaaaa
     3061 acaactattc ttcgaatgat cgcaggtctg gaaaccccgg acagcggaga ggtcattatt
     3121 gatggaaaag tggtaaatga tgttccggcc agtcagcgtg ggattggatt tgtatttcag
     3181 aattatgcgt tgtttcgcta tatgacagtt tatgacaacg ttgcatttgg tttgaaggtt
     3241 cagaaggctg ataagaagaa aattgatgcc agagtcagag agctgatcaa actggtgggg
     3301 ctggaaggac tggaaaaaag atatccaagc cagttatctg gcggccagag gcaaagggtg
     3361 gcatttgcca gagcccttgc tccaaatccc caggtgctgc ttctggatga gccctttgca
     3421 gccattgatg caaaaatccg tcaggaactg cgaagctggt taaaagagat gatcgggaag
     3481 ctgggaatta ccagtatttt cgttactcat gatcaggatg aggccattga agtagcagat
     3541 gagattatta tcactaatgc aggacggatc gaacagaaag gaactcccat aggggtttac
     3601 agaaatcctg agacagcttt tacagcgtcc ttcttcggac agccatctgt gttgaaaaat
     3661 gcggatgatt tccatacctt tgctcaggca gaaggagcag acaagattat tgtccgcccg
     3721 gaatttgtaa aaatctccaa actggatgag gtggagaagt tcaaaacttc cgtatcccgg
     3781 ggagtggttg aacaggtttc tttcagggga gataatctgg aacttcaggt gagagtcaac
     3841 aattccgtag taactgccag aagaagcctg gagaaagcag atatccggga aggtgagact
     3901 gtgaatgtat tcctttacag gatttttgca ctgagaggtg acagtgtaca gctgatcgaa
     3961 aatgaggctg taagggatga ctttgtaatt atctgacagc ggtggctgcg gcgactgacg
     4021 acaaagaaga aataagaaat tcagacgcaa gactgatcgg gaaatcaact tgttggcaca
     4081 ctggtatgga ggaaagggta agagagaatg agaacagaga gaatcaggac agatgtgctg
     4141 atcatcggcg gcggtacggc aggatgcttt gcagcctatg tgatcggcaa aaaaagcggc
     4201 agaaaagttc tgatcgcaga gaaagcgaat attaagcgaa gcggatgtct ggcggcgggc
     4261 gtgaatgcat tgaacgcata tattacagaa ggcagagtgc cgcaggatta tgtggattat
     4321 gccaaaaagg atgcccatgg aatcgtaaga gaagaccttc ttcttaccat gtcagagaga
     4381 ctgaatcatg tgacaaaggt gatggaagat ctggggctgg tcatcctgaa ggacgaaaac
     4441 ggaaaatatg ttgccagagg aaaccgaaac atcaagatca atggcgaaaa tatgaagcca
     4501 atccttgcaa aggcggcagc tgaacaggag aatgttacgg ttctcaatca tgtaaatatt
     4561 acagattata aaacagaaaa caaaaaagtc acaggcgcag ttggatttag cgttaatgag
     4621 gatattttct atgacattga tgcgaaagca gttctttgtg ccacaggtgg tgcagcggga
     4681 ctttacagac cgaataatcc gggattttcc agacataaga tgtggtatcc tccgtttaac
     4741 acaggtgcag gatatgcaat gggacttctt tccggtgcgg agatgacaac ctttgagatg
     4801 cgtttcattg cattgagatg taaggacacg attgctccta caggaactat tgctcagggt
     4861 gttggggcca gacaggtcaa tgcacatggt gatatttatg aaacaaaata tggtctgaca
     4921 acttcccagc gagtttacgg tacagtcatg gagaacagag aaggaaacgg tccatgttat
     4981 ctcagaacgg aaggtatttc caaagaacag gagcaggacc tttacaaagc ttacctgaat
     5041 atggcaccgt cccagactct gaaatggatg gaagccggaa aaggaccatc cgaagagaat
     5101 gtagagattg agggcacaga gccatatatt gtaggtggac atacagccag cggttactgg
     5161 gtagataata acagagctac aactattgaa ggtttatatg cagccggaga cgtagcagga
     5221 ggatgtccgc agaaatatgt aaccggcgca ctggcagaag gtgagatcgc agcagaggcg
     5281 attttggaat atctgaatgg caaagatgat gaccggatcg cagcggaaaa taaggaagaa
     5341 gaggctttag agcgtggcgg agaacaggag ctgtctcaaa ctgcaacagc taagaaggca
     5401 gaatacgaat cacatttgaa tgcttcccgt tctttgatga atgcagagca gcttgaggaa
     5461 gccatgcaga agatcatgga tcagtatgca ggaggaatcg gtacagacta cagatacagc
     5521 gggatgagtc ttgcaaaggc agatgaaaag atcgcagcat tgttgccagt agttgacact
     5581 ctggcagcaa cagatactta tgaactgatg cagatttatg aacttcgcga acgactgatc
     5641 gtgtgccagg cagtgatcgc acatctggca gccagaaagg aaaccagatg gcatagtttc
     5701 ggagagaata cagactaccc gcagcagagc gaagagtgga tgaaatatgt aaactcccgt
     5761 atggaaaacg gcgagattaa gatcttatat cgtgacctga tcacaaagga aaatacaggt
     5821 ttgaatacag cagagaaagg agcaggtgag agatgagcat tcggattcag aaaagtaaat
     5881 gtgcaggatg cggcagatgt atcgaagcct gtcccggaaa tctgatcaaa aaggataaag
     5941 agaacaaagc ctttatccgt caggtaagag actgctgggg atgtacttcc tgtattaagg
     6001 aatgcaggca tgatgccatc cgctttttcc ttggagctga tgtgggaggc agaggtgcaa
     6061 gtatggttgt atcagagaaa ccggatattt ccacatggac agtggagaag ccggatggca
     6121 ctaagatcac tattcaggtt aataagaaag acgctaataa atattaaaca taagtatgta
     6181 ctctcagagt ctttagagtg tgtttgaaaa atgctttacg caagatgtgc gtcacaattt
     6241 gtgggagatt ttgttcggat gagggcgtcg tagtgggcta cgacaaccga attcggacaa
     6301 aatataccgc aaagtggggc gtgcagattg cgggaatgat ttttcagaca cgctctagtg
     6361 tatttgctca agtacgaaaa gattccgagt ataaacaaac agaggaggat aatgcaatga
     6421 gtaacttatc tcatcttgat gcgcttgagg cagaggcgat ttatattatg cgagaagtag
     6481 cagccgagtg tgaaaagccg gttatgctct attctatagg aaaggacagc tccgttatgc
     6541 tccatctggc gatgaaggca ttttacccgg agaaacctcc attcccgttc cttcacattg
     6601 atactacatg gaaattccat gagatgatcg aattccgcga cagaatcgca aaggaaaacg
     6661 gaattgatat gctggtttac accaatgaag agggtgtaaa ggcaggaatc aatccatttg
     6721 acaatggttc tgcatataca gatatcatga aaacacaggc gttaaaacag gctctgacca
     6781 aatatggatt tacagcggca tttggaggcg gccgtcgtga tgaggagaaa tccagagcaa
     6841 aagaaagaat cttctctttc cgtaattcag ctcaggcatg ggatccgaaa aaccagagac
     6901 cggagatgtg gaagctttat aacactaaga tccagaaggg agagagtatg cgagtattcc
     6961 caatttccaa ctggacagaa aaggatatct ggcagtacat tcagcgtgaa aatatcgaaa
     7021 ttgtaccgtt atattttgcg aaagaaagac cggtcatcta cagagacgga aatatcatta
     7081 tggtggatga tgacagatta aaactccgtc cgggtgaaaa gattgaaaac aaaaaagtca
     7141 gattccgtac tcttggatgc tatccgctta ctggaggtat tgaatctgaa gcagatactc
     7201 tggatgagat tattgatgag acgttaagtg ctgtttcttc tgaacgtacc agcagggtga
     7261 tcgaccacga ggcagcaggc agcatggaga gaagaaagag agaggggtat ttctagaatg
     7321 aaaggattat tgaaatttat tacatgcgga agtgtggatg atggaaaatc cactctgatc
     7381 ggacatattc tttatgatgc aaagcttctc tatacagatc aggagaaagc tctggagctg
     7441 gattccaaag taggaagcag aggcggtgcc attgattatt ctcttcttct ggacggtctg
     7501 atggcagagc gtgaacaggg aatcaccatt gatgttgcat accgttattt tacaacagat
     7561 aacagaagct tcattgttgc agatacaccc ggacatgaag aatatacaag aaacatggca
     7621 gtgggtgcgt cctttgcaga tctggcagtt atcctggtgg atgcttcaca gggagtactg
     7681 gtacagacaa gacgtcatgc aagaatctgc gcattgatgg gaatccgtta ctttgtattt
     7741 gcagtaaaca aaatggatct tattgaatat gatgaaaaac gtttccgcga cattgagaat
     7801 cagatcgcag cactgataga agaactgaaa cttgccaatg taactattat tccggtatct
     7861 gccacagaag gtgacaacgt tacaaccaaa tctgacaaca tgccatggta taaaggtgag
     7921 gcgcttcttt cccatctgga aaccgtagac attaaggaag atacagagaa gggcttctat
     7981 atgcctgtac agagagtctg cagaccaaac catgagtttc gcggattcca gggacagatt
     8041 gaaaatggtg ccatcagggc aggcgacctt gtgactactc ttcccagtaa agaagaagct
     8101 catgtaaaga gtattcttgt tggcgataaa gaagttcagg aagctgtaca gggacagcct
     8161 gttaccatcc agcttgacag agaagtagat gtttcccgcg gatgtgtact taccattgat
     8221 tccggcgcag ttcttacaga ctctgtggaa gcagatatcc tctggatgga tgacaatgct
     8281 cttacggatg gcaagaactt ctttgtaaaa atcggtacaa agatgatccc cggcctggtt
     8341 acaaagatca attattctgt ggatgttaat acaggtgaaa agaaaagcgc atatacctta
     8401 aagaaaaatg agattgcttc ctgtactctg gaattctcag agaagatcgt tgtagacgaa
     8461 tttgacaggc acagaacact gggtgagctg atcctgatag atcgtgtcac aaatatgact
     8521 tctgcctgcg gtgttgtgag aaaaaccttt gtttctcagg atagatctca gatcggaaaa
     8581 gtggacgagc aggttcgtgc aggactgaaa ggtcagacac cggtagtagt ggaattcccg
     8641 atcggtaaag aaggaatcac tcttgatttt gcagagcagg tagaaaaggg actgactgta
     8701 cttggaaaac atacctatct gtatcatccg gcagcgagtg aaaactatgc agaaactgtc
     8761 cgccatctta aggcagcagg tctgatcgta cttcttgttc ttgatgaaaa tacagcaaaa
     8821 gacgagacat taaagactct ggatggtttc tatgcgaact ggcagattga cggaatcact
     8881 gtgaaagatg cgattgattt cgtgaaaaag aaatctgcat ttacagtgca gagtgtacat
     8941 gatggaaatt atatctgatt ataacagggc tataaatcgc cgcagagaca aagaaagtct
     9001 ctgcggtatt ttgttttctt gacaagtgtt gttacagcgg attatactta ttttcaaata
     9061 ttcagaatcc ataataatac agacaggaaa gataacagaa atatgcaaac gaacaatgaa
     9121 agtaaacaaa accaaaaaaa gagatgatgc ttggaacttt gtttgtaatt gctacgatca
     9181 tcatcctggc gataccaacg aagaaaagac agaaataaag atgagtgaat atcgatcaga
     9241 atgtagaatg ggcaattggt tactgttcac acaccactat cccgcgaggt gttttggcat
     9301 gaatatgcca aaatcccgag acatacaagc caaaattcca ttgccacagg caatctggaa
     9361 tgaattttgg ctaagttact gtgaacggag tgaacagtaa cggcaattgt gaagtggcat
     9421 tcagattaca tattatgcag cagagtatga tataattcgt tttgtataat ggcgtcagga
     9481 ttaagagcat atgtagagct gtgtagcgaa gcggattgcg aatatctgtt tgacttttga
     9541 tgggtgtaca cgagaacatt tttttacagt gaaagttatc tgtattatat tacagagggt
     9601 actgtacaga taatcaggag gtattttatg cgtttggaaa aagtacagga agcgttaaaa
     9661 acaaagaaaa ttcattatga atatacagag gaaaacggat gcggaagcat cgactttatg
     9721 tttcgcggtc tgagattcca tatatgggaa tatgaagatc gtgtctgggg agcggagaca
     9781 aacgtgttcg aagcaggcag aagccaggat attgagggag attacgagga aattatttcc
     9841 ggagaaatcc tctcatggcc ggatatgctg cctgggatgt aagtattact gcagaaggga
     9901 atgatattta cgaaaaaatg tagaaccgga caaattgtat taactgcatg tattgtagct
     9961 gtctgtatgt tttcaaatgt ccatgggaca gaagcggcag gtccgccggc accgaaaact
    10021 ctgacagtta caccgccaga aaaaccgaaa tcaatagcaa agtcaaagtc cacgtcaaca
    10081 tcaaagtcca aatcaacacc gaaatctaaa tcggcactaa cacaaaaacc tgaagcaaca
    10141 ccaatacctg catctactcc aacaccagag caggaagctg agacagataa acagaatccg
    10201 gcagatcagg gaactttaag caagccagat catccggata ctatctccgc agataaactg
    10261 gtatttatcg gagattccag aacagaggga ttgagggatg cggtaaatga tgacagcatt
    10321 tggtcctgtc tttcttctat gggatatgac tggatggtat ctacaggagt gcctcaggta
    10381 gaagatcaga ttgaggacaa tacagcggtt attattctga tgggtgttaa tgacctgtat
    10441 catgttaatg actacatcag ctatattaat tccaaagctg ccgaatgggg aaacagggga
    10501 gcgcagactt attttgtgtc tgtaggtccg gtgcagaatg atccctattg cagtaatgcg
    10561 gagattgaaa gcttcaatgc ggcaatgcag gcaaatctga gtggggttac ctacatagac
    10621 gtatattccc atctggtatc tgagggattt tccaccgtag acggaaccca ctatccggac
    10681 agtgtgtctg tagatattta taattatatt ctggatcatc tggaggaaca gaggagtgga
    10741 atctggggat gatttttcag tttatgaaat tgtgatgctg tattgagttc gatggagttt
    10801 ggtgatatga ttgcagagga agaaacggaa tagagcggaa attcgttttt ttatataaaa
    10861 gctgaaaacc tggcaggagg aaataatggg tggctgtttt gcagcagagc caaaaatgta
    10921 aatgataatt gcccgatgac tggacagtta tcaaaatcca aaatcaggag gaaagaatga
    10981 gaggactgta ttcatccaaa acagagatca gacacaaaat ttttacggaa attgcgagga
    11041 tggcatatga aggccagtct ccggagatgc tggaagagct tccctacaag atcgtacccg
    11101 gtgaaattgc gacttatcgt gacagtattt ttctggaaag agcggtagtt ggtgagagac
    11161 ttcgcgttgc aatggggatg tcactgagaa aggttacaga gcatgcgcca atctccaaag
    11221 gtgtggaggc cagcgttatt gaggaaaagt attatgaacc gccgcttatc aatgtaatca
    11281 agtttgcctg taattcctgc cctgagaaaa gggtaatgat cacagagggc tgtcagggct
    11341 gtctggagca tccctgtgtg gaggtctgtc caaagaaagc agtacatatg gaaggcggca
    11401 gatcacatat tgatgaagat gcctgcatca aatgcggaaa gtgtctggaa gcctgtccgt
    11461 ataatgcaat catcaaacag gaacgtccct gttcaaaggc ctgcggcatg aatgccattg
    11521 gttctgacga atacggaaga gcagagattg accaggacaa atgtgtatcc tgcggccagt
    11581 gtctggtgag ttgtccgttc agcgctattg tagacaaagg acagattttc cagactgtta
    11641 tggcattaaa aagtgaaaca ccggtgtatg caatcgtggc gcctgccatt gcaggtcagt
    11701 tcccgggtat ggagaataat aagatacggg gtgcatttca ggcacttggc tttacagatg
    11761 taagagaggt tgccgtcggt gcagatctgt gcacagtgga ggaggcaaag gactttttgg
    11821 aggaagttcc tgagaaactt ccgtttatgg ctacatcctg ttgtccgtcc tggtctatga
    11881 tggctaagaa attattcccg gaacaggcga aatgtatctc catggcactg acacctatgg
    11941 ttcttactgc cagactgatc aagcagaagg aaccgaattg taagatagtt ttcgtaggtc
    12001 cctgtgcagc caagaagctg gaagccagcc gtaagagtat ccgcagctat gtggattttg
    12061 tgctgacctt tgaggaagtg gcaggaatgt ttgatgccaa aggcgtggac tggaaagata
    12121 ttccggaagg agaaccactg tttcgtgcca gtgctgacgg aagaggtttc gcagtcagcg
    12181 gtggtgtggc agaagcggtt gtccatgcgg tgaagcgtat tgatcctgat cgggaagtaa
    12241 aggtaatgaa tgcagaaggt ctgcagaact gtaagaagat gctccagatg gccaagattg
    12301 gtaaatataa tggatatctt ttggaaggaa tggcatgtcc gggcggctgt gtagcaggtg
    12361 ccggtactat ccagacagtt aaaaaagcag cagcagctct cgaaaaaatg aagaaagagg
    12421 cttcgtttac agatgcctat gactccaaat acagagcaag actggaaagc ctggagaaat
    12481 ttgatgtgga gtgagattct gactgaatca gtgaaatcct atatggattg caagtgtttg
    12541 aatgcaatca gtatatagca ga
//
