LOCUS       c00052_gnlPro..        14239 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PHBDMBEL_52.
ACCESSION   c00052_gnlPro..
VERSION     c00052_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:28:46
            Original ID  :: gnl|Prokka|PHBDMBEL_52
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14239
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14239
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5139:9382]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5140..9382
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..14239
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14239
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             191..667
                     /locus_tag="ctg52_1"
                     /transl_table=11
                     /translation="MIYDTLNNLPNYLGVSDNLDTVIEYIMARDITTLPAGRTRIDGDK
                     AVVTVSTVTPQTSDKALFQRHDNHITLETDLDGSELFEVSLAELTPTKPTDEAADTTVG
                     TAGTSIAGMLCEGRFALYLAGEPYKSGLKAQGCGKLKKAVFSIELDPDEEETEE"
     CDS             687..926
                     /locus_tag="ctg52_2"
                     /transl_table=11
                     /translation="MGFFAVLAASLFAVFIFTVFGGYSLLLWCQQSLWMVVPPALVLAV
                     LVWTFLKMDDKITALQKRVDELEAAQKSTEKLEK"
     CDS             complement(1012..2328)
                     /locus_tag="ctg52_3"
                     /transl_table=11
                     /translation="MDLALFGRYFLDFALLYPSAFLCLASLWEKLRTPRRTACIAAGCI
                     TLLCIGCAALCAVFGLNSNSLLPAIVLVSFWLLRWRVTPEVTVSQTAFLFSISAVMMAV
                     CSLLSTLLNAQTEISNPQTVCLASTALLRLGLAAMLTVLFWFTAVQWSRWLLREYSGEA
                     FWQSAWPLPALYAVFLVYCMPLNPAVVLVGRLKIISVLAVSISLFGIFLLLYEMYRVAR
                     EFTRNARLDRENQLLAMESRRYMELQTYLDNTRRLRHDFRQHLHVIAGLTETGQLEELK
                     SYLHQYESELSEHRPSLCANAAVDALAGYYDHAAGQQSVPVEWKLALPRQLPMPEADLC
                     TILGNLLENALHASQKLPPEQRRVQVMAQMLSPAMLGLVVENRYDGMLKKQQGILHSTK
                     HEGTGIGLVSAETVVHKYNGNLHLETEEQIFRVNVLLNL"
     CDS             complement(2346..3089)
                     /locus_tag="ctg52_4"
                     /transl_table=11
                     /translation="MEKEGVWMALPIAIVEDQAADARRLEELLQQQLPEAECTWFTCGD
                     DFLRAAAEPGLYAVVFLDICMAGTNGIETARRLRQADPEVLIVFVTSSPEYVWDAFPVH
                     PFDYLLKPYQKEKFVHLAAELRRALRCKEPELEIRIARQSIQLPLRKVLYAIARNHYVL
                     ITTEDGEYRAMCSFAQIEEKLTALENFMSCNRGVIINMDKVLRFGEDCIEILDGTRLPV
                     RQKDKCTLLAHFTQYQFRHMRQELH"
     CDS             3661..5127
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_5"
                     /sec_met_domain="OKR_DC_1_C (E-value: 5.3e-12, bitscore:
                     36.3, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 3.5e-123,
                     bitscore: 401.1, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNENKARSRLDQRRAPIYEALERFRQMRVVPFDVPGHKRGRGNPE
                     LTAFLGQQCVGVDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSSVQS
                     MVLTACKRGDEIILPRNVHRSVLNALVLCGAVPVYVNPEVDKRLGISLGMKREQVAKAI
                     KEHPNAVAVLVNNPTYYGICSDLRAIVKMAHDAGMLCLADEAHGTHFYFGGGLPVSAMA
                     AGADMASVSMHKSGGSLTQSSLLLIGPNVHPGYVRQIINLTQTTSGSYLLMSSLDISRR
                     NLALRGRQVFHQVADIAEYAREEINAVGGYYAFGKELCNGDSVFDFDTTKLSVHTLDIG
                     LAGIEVYDILRDEYDIQIEFGDIGNILAYLSIGDRPQEVERLVSALAEIKRRYRTDGSG
                     LLSQEYIDPVVAASPQEAFYAPKKSLPLRETEGMVCSEFVMCYPPGIPILAPGERITKE
                     ILNYIEYAKAKGCSMTGPEDPEILHLNVLA"
     CDS             5140..5997
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_6"
                     /sec_met_domain="Spermine_synth (E-value: 3.6e-54,
                     bitscore: 173.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 3.8e-23,
                     bitscore: 71.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFWFSEFHTPDVKHSIRVNKQLYSKQSDYQRIDIFETPEFGRVL
                     TLDGNVMLTERDEFIYDEMIVHVPMAVHKEAKDILVIGAGDGGVVRELTRYDRVERIDL
                     VEMDPQVVEACRAYLPGNACRMDDRRVHIYFENALKYIRRCEEEYDLIIVDSSDPFGPS
                     EGLFTREFYGSCFNALKEDGIMVNQQGSPFYAEDASAMQRSHKRIASTFPISRVYQAHI
                     PTFAAGYWLFGFASKKYHPIDDLDAEAWKALNMRTRYYTTKLHIGAFYLPAFLEEMLRE
                     VEEH"
     CDS             5997..6872
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Arginase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_7"
                     /sec_met_domain="Arginase (E-value: 5.1e-77, bitscore:
                     249.1, seeds: 235, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPNVETFIGCDSSYRAASIVLYGAPYDSTTSYRPGARFGPAAVR
                     HESYGLETYSPYQNADLTDFDVFDSGDLELCFGSSELALSDIEARAEEILKDGKFPLLL
                     GGEHLVTLGAVRAAVKKYPDLHIVHFDAHADLRDDYLGAKLSHACVLRRCHELVGDGHI
                     HQFCIRSGDRAEFEFAAQHTEMHKFDFTGLAELTAQLCESKVPVYLTIDLDCLDPSCFP
                     GTGTPEAGGVSFLQLLDAIRTVTKANIIGADLNELAPTLDTTGVSTATACKVLRETLIA
                     LDKGWPGFQV"
     CDS             6912..8171
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_8"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 4.4e-45, bitscore:
                     144.9, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 1.6e-33,
                     bitscore: 105.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVLIIGCGGVASVAIHKCCQVPEVFTEICIASRTKAKCDKLAA
                     ELAPTTTTKITTAQVDADKVEEVIALIKAYQPDLVMNIALPYQDLTIMDACLACGVNYM
                     DTANYEPENTDDPEWRAIYEKRCKEAGFSAYFDYSWQWAYAKKFEEAGLTALLGSGFDP
                     GVTQAYCAYAKKHEFDTIDTIDILDCNGGDHGYAFATNFNPEINLREVSAPGSYWENGH
                     WVEIPAMSIKREYNFDQVGDKDMYLLHHEEIESLAKNIPEAKRIRFFMTFGQSYLDHMR
                     CLEDVGMLSTTPVNFNGQEIVPIQFLKALLPDPASLGPRTKGKTNIGCIFTGKKDGKDK
                     TYYIYNVCDHQECYKEVGSQAISYTTGVPAMCGALMLLTGKWTTKGVHTVEEFDPDPYL
                     DALDKYGLPRSESHNPALVD"
     CDS             8171..9382
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_9"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 5.4e-14,
                     bitscore: 42.4, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVRDSRPPFAGLANLSEEQLHRLPTPCYLLDEAQLRRNGEILLG
                     VQQRTGCRILLAQKAFSNFNVYPVLAPYLAGTEASGLYESRLGREELPEKENHVFCAAY
                     RADEFEELLQYADHIVFNSPSQLAKFGPAAKAAGKSIGLRINPECSTQEGHEIYDPCAP
                     GSRLGTTRAQWNAAVAAHPELPALLDGLHFHTLCEQDADALAVTLAAVEEKFAGLLPRM
                     KWLNFGGGHHITRPGYALDTLESCILSVRQKYGVQVYLEPGEAWALNAGYLVTTVLDTL
                     CNGDTSLAILDMSAACHTPDVIEMPYRPPLLDAGEAGEKAHTVRLGGPTCLAGDIIGDY
                     SFDAPLAEGDKLIFGDMAIYTTCKNNTFNGMPLPPIWLLGADGNCRELVHFGYQDFKMR
                     LGAQ"
     CDS             complement(9398..9556)
                     /locus_tag="ctg52_10"
                     /transl_table=11
                     /translation="MDCKRVTVIRIGPVISTRMKALHGNVWCFFVLSAVHLTSSFMKKA
                     FVAARRP"
     CDS             10043..10912
                     /locus_tag="ctg52_11"
                     /transl_table=11
                     /translation="MTLDYFYGQTGELFSFYRIPKALFQEQRFQSLSTDAKTLYGILLD
                     RMSLSVKNGWLDKQNRVFIIFTIEDVKRALCCADNKATKLLRELEKFGLIERKRRGQGK
                     PSLVYVKNFSAESSKESVKNRDNDDSCGFKIACQDPAKSRCNKTKENDTEMSETNLFYS
                     EESDGMSKRAQLEEYFSQSLEVDLLLRLCPDDEDTIYQIVDLLVDTCATNRKLLHIAGD
                     DKPAEVVRSRFMKLNADHIKFVLKCLAENSSPIRNMKQYLLASLYNAPTTMQLYYQNQT
                     NHDLAKRG"
     CDS             10909..11745
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CbiA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_12"
                     /sec_met_domain="CbiA (E-value: 1e-27, bitscore: 86.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIKISKKATTIAIVNQKGGTGKTTTCENLGVGLAAEGKKVLLVDA
                     DPQGSLTISMGWQKPDELPVTLSTLMQKAMNDQCIPPGEGVLHHAEGVDLIPANIELAG
                     LEVALVNTMSREKMLKQVLDSAKQDYDYILLDCTPSLGMLTINALAAADTALIPVQAQY
                     LSAKGLEQLLQTINKVHRQINPKLKIEGILLTMTDNRTNYGRQIDTLIRQAYGKHIKVF
                     GQTIPHSVRAAEISAAGKSIFVHDPKGKVAEAYKSLTKEVLADAKKQRKRQSEQLR"
     CDS             11702..12628
                     /locus_tag="ctg52_13"
                     /transl_table=11
                     /translation="MPKSSVNASLSSYDDIFSTEESRQEEQREQVQQIPIGELFPFKNH
                     PFKVLDDDSMSDTVESVKQYGVLSPLIARPRPKGGYEIISGHRRQHAAELAGLETLPVI
                     VRQMDDDAAIILMVDSNLQREHILPSERAFAYKMKLDAMKNQGTRSDLTSTQVVSKLRS
                     NEKLGAENNQSRETVRRFIRLTNLIPELLDMVDNKTVSFNPAVELSYLSPEQQQEVIRA
                     MDDTQNFPSVSQAKRIKKLAQDGTFTTETIVAIMGEEKKSELDTVTIKNDTLRKYFPRS
                     YTPKQMEDTIIKLLEQWQKKRQHSEER"
     CDS             12691..13116
                     /locus_tag="ctg52_14"
                     /transl_table=11
                     /translation="MKNDSNPIIRSEEVTIDMHICAALSESRSSGEIYFAAIAPDMELT
                     VITLDEAPDILPCFDEDDAYLNIPDSSLLLSYNPAQVLKLAGKHYLTGPVILVRTNMDG
                     EFISLTIDQVYLFQKYLMRHSVTLMADGQKLPCICME"
     CDS             13183..13599
                     /locus_tag="ctg52_15"
                     /transl_table=11
                     /translation="MYPGLSHDEIIEECIKELNHYFEVGPEVALISAEKGVQCVPFDES
                     PQKKFPYFEGTYEVFDVPHTDFQIRYQPEQILAANGRKILTGTAFLCRKENERCLMLPS
                     RYEKVDVEDFIREHLFFYDDAETRHVGVELSEVA"
     CDS             13723..14169
                     /locus_tag="ctg52_16"
                     /transl_table=11
                     /translation="MEQEKNTLTVLEIAPGHYPKQVEIDPDLKALQQAVGGNIGASYPF
                     SDPVAIVYNDEGKLMGLPLNRALRDGSGEAYDVVAGTFLVVGLGEEDFASLSPELAQKY
                     EEHFHQPEDFIQLGHRMMIVRVPDEAVSPEDSKTAPPKDAGHDR"
ORIGIN
        1 gggaggagct gttggggctg cggccagcag gatgcgcgtg ccgcccaagg cacgacgcag
       61 ccgctgggag ccgcgacccg ggttcctttt ctgcgcggct cgcgacatcc gcccgcacac
      121 atattgcatc tgtccctgac ctgtgatacc atacaggtaa ctgaaacaac acagacggag
      181 gactttttcc atgatctacg ataccctgaa caacctgccc aactatctgg gcgtaagcga
      241 caatctggac accgtgatcg agtacatcat ggcgcgggat atcaccaccc tgcctgccgg
      301 gcgcacccgc atcgatgggg acaaggcggt ggtcaccgtg agcaccgtca cgccccagac
      361 ctccgacaag gcactgttcc agcggcacga caatcacatt acgctggaga ctgacttgga
      421 cggcagtgag ctgtttgagg taagccttgc ggagctgacg cccaccaagc caaccgatga
      481 agccgccgac accaccgtag gcactgccgg taccagcatt gccggaatgc tgtgcgaggg
      541 acgctttgcc ttgtatctgg cgggggaacc gtataaatcc ggcctgaagg cgcagggctg
      601 cggcaagctg aaaaaagccg tgttcagcat tgagctggac ccggacgagg aagaaacgga
      661 agaataactg aaaggagact ttctgtatgg gattttttgc tgtactggct gcaagtctgt
      721 ttgccgtatt tatttttact gtattcggcg gctattcgct gctgctctgg tgtcagcagt
      781 ccctgtggat ggtcgttcct cccgcgctgg tgctggccgt tctggtctgg acatttttga
      841 aaatggacga taagatcacc gccctgcaaa agcgggtgga cgagctggaa gccgcacaaa
      901 aaagcacgga gaagcttgaa aaataataca gcgccgccct tcgtagagaa acctctctgc
      961 aaaggacggc gctgcttttt tgtgaacgct ttcacgttgg cctgccggtg gttacagatt
     1021 taacagaaca ttcacccgga agatctgctc ctcggtctcc aaatgcagat tgccgttata
     1081 tttgtgcact accgtctcgg cagataccag cccgatgccg gtgccctcgt gcttggtgga
     1141 gtgcaggata ccctgctgct ttttcagcat gccgtcgtaa cggttctcca ccacaagccc
     1201 cagcatggcg ggactgagca tctgcgccat cacctgcacc cggcgctgct ccggcggcag
     1261 cttctggctg gcgtgcaggg cgttttccag cagattgccc agaatggtgc acaggtcggc
     1321 ctccggcatg ggaagctgcc gaggcagtgc cagcttccac tccacaggaa cgctctgttg
     1381 cccggctgca tggtcgtaat atccggccag tgcatccacg gcggcgttgg cgcacaggct
     1441 ggggcggtgc tcactgagtt cgctttcata ctggtgcaga tagcttttca gctcctccag
     1501 ctgcccggtc tcggtcagtc cggcaatcac atgcagatgc tgccggaagt cgtgccgcag
     1561 acggcgtgtg ttgtccagat aggtctgtaa ctccatgtac cggcgggatt ccatggccag
     1621 cagctggttt tcccggtcca gccgggcatt gcgggtaaac tcccgggcaa cgcggtacat
     1681 ctcgtacagc agcagaaaga tgccgaacag cgagatggac accgccagca ccgagatgat
     1741 cttcagtcgc ccgaccagca ccacggcggg gttcagcggc atacagtata ccagaaaaac
     1801 ggcatagagg gcgggcagcg gccacgcaga ctgccagaag gcttcaccgc tgtactcccg
     1861 cagcagccac cggctccact gcacggcggt gaaccagaac agcacggtga gcatcgcggc
     1921 aaggcccagc cgcagcagcg ccgtggaggc aaggcagacc gtctgtgggt tggagatctc
     1981 ggtctgggcg ttgagcagcg tcgacagcag ggaacacacc gccatcatca cggcagagat
     2041 ggaaaacaga aacgcggtct ggcttacggt cacttccggc gttacccgcc agcgcagcag
     2101 ccagaaggag accagcacga tggcgggcag gagagaattg ctgttcagcc cgaacacggc
     2161 gcagagcgcg gcgcagccga tgcacagcag ggtgatgcat ccggcagcga tgcaggcggt
     2221 gcgcctgggg gtgcgcagct tttcccatag ggatgccaga cacagaaacg cgctgggata
     2281 cagcagcgca aaatccagaa aataacggcc gaacagagca agatccatgg cggctgctcc
     2341 tttcctcagt gcagctcctg ccgcatgtgg cggaactggt attgtgtaaa gtgggcaagc
     2401 agagtgcatt tatccttttg ccgtaccggc aggcgggtgc cgtccaggat ctcgatgcag
     2461 tcctccccga accgcagcac cttgtccatg ttgatgataa cgccccggtt gcagctcata
     2521 aagttttcca gagcagtaag cttttcttcg atctgcgcaa agctgcacat ggcacggtac
     2581 tcaccatcct cggtggtgat aaggacgtag tggttccggg caatggcata cagcaccttg
     2641 cgcagcggca gctgaatgct ttggcgggca atgcggatct ccagttccgg ctccttacaa
     2701 cgcagcgccc gccgcagctc ggcggcaagg tgcacgaatt tttccttctg gtagggtttg
     2761 agcaggtaat cgaaggggtg caccggaaag gcgtcccata catattccgg ggaggaagtt
     2821 acgaatacga tcagcacctc cgggtcggcc tgtcgtagcc ggcgggcggt ctcgatgccg
     2881 ttggtgcccg ccatgcagat atccagaaac accacggcgt ataagccggg ctctgctgcg
     2941 gcacggagaa aatcatctcc gcaggtaaac catgtgcact cggcttcggg cagctgctgt
     3001 tgcagcagct cttccagccg ccgggcatct gctgcctggt cctctacgat ggcgattggc
     3061 agtgccatcc atacaccctc tttctccatt cattgttcct ttattatagc atactgcggc
     3121 gggaagggta tctgcttttt tgcacaaaac gccccatttt gcgcgccgag cgccgccctg
     3181 cgcacccgca gcgggcgact gccaaaaagt tttggttgac agacggggcg aatcatgtta
     3241 ttcttttgtt gattttgaga gacgccgcct tgcagagtct tttcaaagca atttactcgg
     3301 gaccgcccaa acggggctaa ggccatacgg acagccgggt ccactgccga ccggcggcgc
     3361 aagctgccat tattgattga gtttgaagct caaattttat aagttggttc ctttacaacc
     3421 atgaaattgc gcagcctatg cgcagacttg tgaaacggtc aataagagta gtaaaagtgt
     3481 agttgctata tagactctca tcaccccgtc tttttggatc gcaaataacg cgcagcaccg
     3541 gcacttacgg ctgggtgctt tatcagcgcg gaaaaagctt ttccaagcgc aggtctgcat
     3601 atttgtgcag tgcctgcgct tttttgttgt gcaaaaagaa gaacagggac ggaggaaaag
     3661 atgaacgaga acaaagcgcg ttcccggctg gatcagcgcc gtgcgcccat ttacgaggcg
     3721 ctggagcggt tccggcagat gcgggtggtg ccttttgacg tgcccggcca caagcgtggc
     3781 cgcggcaacc cggagctgac cgcttttctg ggtcagcagt gcgtgggcgt ggacgtgaac
     3841 agcatgaagc cgctggataa cctttgccac ccggtgtcgg tcatccggga agctgaggag
     3901 cttgctgccg atgcctttgg cgcagcacac gcctttttaa tggtgggcgg caccaccagc
     3961 agcgtgcaga gcatggtact taccgcctgt aagcggggcg atgagatcat tctgccccgc
     4021 aatgtgcacc gcagcgtgct gaacgcgctg gtgctgtgcg gcgcggtgcc ggtgtatgtg
     4081 aacccggagg tggataagcg cctgggcatc tcgctgggca tgaagcggga gcaggtggcc
     4141 aaggccatca aggagcaccc caacgctgtg gctgtgctgg tgaataatcc cacctactac
     4201 ggcatctgct ccgacctgcg tgccatcgta aaaatggcgc acgacgccgg gatgctctgc
     4261 cttgcggatg aagcccacgg cacccacttc tactttggcg gcggcctgcc ggtttctgcc
     4321 atggcggcgg gcgcagatat ggcctcggtg tccatgcaca agagcggcgg cagcctgacc
     4381 cagtccagcc tgctgctcat cggtcccaac gtgcacccgg ggtatgtgcg tcagatcatc
     4441 aacctgaccc agactacctc cggcagttac ctgctgatgt ccagtctgga tatctcccgc
     4501 cgcaatctgg cgctgcgggg acggcaggtg ttccatcagg tggcggacat tgccgagtac
     4561 gcccgcgagg agatcaatgc cgtgggcggc tactatgcct ttggcaagga gctgtgcaac
     4621 ggcgattccg tctttgattt cgacaccacc aagctcagcg tccatacgct ggatatcggt
     4681 ctggccggca tcgaggtcta cgacatcctg cgggatgagt acgatatcca gatcgagttc
     4741 ggcgatatcg gcaacatcct tgcctacctg tccatcggcg accgcccgca ggaggtggag
     4801 cgtctggtca gtgcgctggc tgagatcaag cgccggtacc gcaccgatgg ctcgggtctg
     4861 ctgagccagg aatacatcga ccccgtggtg gctgccagcc cgcaggaggc tttctacgcc
     4921 cccaaaaaga gcctgcccct gcgggagacc gagggcatgg tgtgcagcga gttcgtcatg
     4981 tgctatcccc cgggcatccc catccttgca cccggcgagc gcatcaccaa ggagatcttg
     5041 aactacatcg agtacgccaa ggccaagggc tgcagcatga ctggcccgga ggaccccgaa
     5101 atcttgcacc tgaatgttct ggcataagga gggaaagaga tggaattttg gttttcagag
     5161 tttcacaccc cggatgtgaa gcacagcatt cgtgtgaaca agcagctcta ctccaagcag
     5221 agcgattatc agcgcattga tatctttgag accccggagt tcggccgggt gctcacgctg
     5281 gacggcaacg tgatgctgac cgagcgcgac gagttcatct acgatgaaat gatcgtccat
     5341 gtgcccatgg cggtgcataa ggaggctaag gatattctgg tcatcggcgc cggagacggc
     5401 ggcgtggtgc gggagctgac ccgctacgac cgtgtggagc gcatcgacct tgtggagatg
     5461 gacccgcagg tggtggaggc ttgccgcgcc tatctgcccg gcaatgcctg ccgtatggat
     5521 gaccgccggg tgcatatcta ctttgagaac gccctgaagt atatccgccg ctgcgaggag
     5581 gaatacgacc tcatcatcgt ggactcctcc gaccccttcg gcccctctga gggtctgttc
     5641 acccgcgagt tctacggcag ctgcttcaac gccctgaaag aggacggcat catggtcaac
     5701 cagcagggca gtcccttcta cgccgaggac gccagcgcca tgcagcgcag ccacaagcgc
     5761 attgcatcca ccttccccat cagccgggtg tatcaggcac atatccctac ctttgcggcg
     5821 ggctattggc tgttcggctt tgcaagcaaa aaataccatc ccattgatga tctggacgca
     5881 gaagcgtgga aggcgctgaa tatgcgcacc cgctactaca ccaccaaact gcatatcgga
     5941 gcattctacc tgccggcttt tctggaggag atgctgcggg aagtggagga acactgatgc
     6001 accccaacgt tgagaccttt atcggctgcg acagcagcta ccgcgccgcc agcatcgtgc
     6061 tgtacggtgc gccttacgat tccaccacca gctaccgccc cggtgcacgg ttcggcccgg
     6121 cggccgtccg gcacgagagc tacggtctgg agacttacag cccctaccag aacgccgacc
     6181 tgaccgattt tgatgtgttc gacagcggcg atctggagct gtgcttcggc tccagcgagc
     6241 tggcactgtc cgatatcgag gcccgggcag aggagatcct gaaggacggc aagttcccgc
     6301 tgctgctggg cggcgagcat ttggtcacgc tgggtgcggt gcgtgctgcg gtgaagaaat
     6361 accccgacct gcacatcgtc catttcgacg cccacgccga tctgcgggac gactatctgg
     6421 gcgcgaagct cagccacgct tgtgtgctgc gccgctgcca cgagctggta ggggatggcc
     6481 acatccatca gttctgcatc cgcagcggcg accgggcaga gtttgagttt gctgctcagc
     6541 acaccgagat gcacaagttc gattttaccg gccttgccga actgaccgca cagctgtgcg
     6601 agagcaaggt gccggtgtat ctgactatcg accttgattg ccttgacccc tcctgcttcc
     6661 cgggtaccgg taccccggaa gctggcggcg taagcttttt gcagctgctg gatgccatcc
     6721 gcactgtgac caaggccaac atcatcggtg cagacctgaa cgagctggcc cccacactgg
     6781 acaccaccgg cgtttccacc gccaccgcct gcaaggtgct gcgcgagacc ctgatcgcgc
     6841 tggacaaggg ctggccgggc tttcaggtat aaatacgaac ctaccatttt acagataaag
     6901 gagtaaccga catgagcaaa gttctgatca tcggctgcgg cggcgtggcc tctgttgcca
     6961 tccataagtg ctgccaggtg cccgaggtgt tcaccgagat ctgcatcgcc agccgtacca
     7021 aggcaaagtg cgataagctg gctgctgagc tggctcccac cactactacc aagatcacca
     7081 ccgcacaggt ggacgcagac aaggtggagg aggtcatcgc cctcatcaag gcctaccagc
     7141 ccgacctcgt gatgaacatc gccctgcctt atcaggatct gaccatcatg gacgcctgcc
     7201 ttgcctgcgg cgtcaactac atggacactg ccaactatga gcctgagaac accgacgacc
     7261 cggagtggcg tgccatctat gagaagcgct gcaaggaggc cggcttctct gcctactttg
     7321 attacagctg gcagtgggcc tatgccaaaa agttcgagga agccggtctg accgctctgc
     7381 tgggcagcgg cttcgacccg ggtgtgaccc aggcttactg cgcctacgca aaaaagcacg
     7441 agtttgatac catcgacacc attgatattc tggactgcaa cggcggcgac cacggctatg
     7501 cctttgccac caactttaac ccggagatca acctgcgcga ggtgtctgcc cccggcagct
     7561 actgggagaa cggccactgg gtggagatcc cggccatgag catcaagcgg gagtacaact
     7621 tcgatcaggt gggcgacaag gatatgtacc tgctgcacca cgaggagatc gagtctctgg
     7681 caaagaacat cccggaggca aagcgcatcc gcttcttcat gacctttggc cagagctatc
     7741 tggaccacat gcgctgtctg gaggacgtgg gcatgctgtc caccacccct gtcaacttca
     7801 acggacagga gatcgtgccc atccagttcc tcaaggctct gctgccggac cccgccagcc
     7861 ttggcccccg taccaagggc aagaccaata ttggttgcat ctttaccggc aaaaaggacg
     7921 gtaaggataa gacctactac atctataacg tctgcgacca tcaggagtgc tacaaggaag
     7981 tgggcagtca ggccatcagc tacaccaccg gcgtgcccgc catgtgtggt gcactgatgc
     8041 tgctcaccgg caagtggacc accaagggcg tgcacactgt cgaggagttt gatcccgatc
     8101 cgtatctgga tgcactggat aagtacggcc tgccccgctc cgagagccat aacccggctc
     8161 tggtggactg atgcgggtgc gcgacagccg cccgcccttt gcggggctgg caaacctgtc
     8221 cgaggagcag ctgcaccgcc tgcccacccc ctgctatctg ctggacgaag cccagctgcg
     8281 ccgcaacggc gagatcctgc tgggggtgca gcagcgcacc ggctgccgca ttctgctggc
     8341 gcagaaggct ttttccaact tcaatgtcta cccggtgctg gcaccctatc tggcaggtac
     8401 cgaggccagc ggcctgtacg agagtcgctt gggcagggaa gagctgccgg agaaggagaa
     8461 ccatgtgttc tgtgccgcct accgggcaga tgagtttgag gaattgctgc agtacgccga
     8521 ccacatcgtg ttcaactcgc ccagccagct ggcaaagttc ggcccggcgg caaaggcagc
     8581 gggcaaaagc atcggtctgc gcatcaaccc ggagtgctcc acgcaggagg gtcatgaaat
     8641 ttacgacccc tgcgcccccg gcagccgtct gggcaccacc cgtgctcagt ggaacgccgc
     8701 tgtggcagcg cacccggagc tgcccgccct gctggacggt ctgcactttc atacactctg
     8761 cgagcaggac gcggacgcgc tggcggtaac gctggcagcg gtggaggaaa agtttgccgg
     8821 cctgctgccc agaatgaaat ggctcaactt cggcggggga caccacatca cccgcccggg
     8881 ttatgctctt gacacgctgg aaagctgcat cctttcggtg cggcagaagt acggcgtaca
     8941 ggtgtatctg gagcccggcg aggcttgggc gctgaacgca ggctatctgg tcactaccgt
     9001 gctggacacc ctgtgcaacg gggataccag ccttgccatt ctggatatgt ccgcagcctg
     9061 ccacaccccg gatgtcatcg agatgcccta ccgcccgccg ctgctggacg ccggcgaggc
     9121 aggggagaag gcgcacaccg tccgactggg cggccccact tgccttgcgg gggatatcat
     9181 cggggattac agctttgacg ccccccttgc cgagggcgat aagctcattt tcggcgatat
     9241 ggccatctac accacctgca agaacaacac cttcaatggg atgcccctgc cgcccatctg
     9301 gctgctgggc gcagacggca attgccggga gctggtgcac tttggctatc aggacttcaa
     9361 aatgcgtctg ggtgcacagt aaaataaaaa gcgtttgtca cggcctgcgg gctgcgacaa
     9421 acgctttttt catgaaagag gacgtaaggt gaacggcaga taaaacaaaa aagcaccaca
     9481 cgtttccgtg tagtgctttc attctggtgg agattaccgg gccgattctg atcacggtga
     9541 ccctcttgca gtccatgcac ggcactctcc tgggtgagct aaaccctcac tcgtttggca
     9601 gcaacaaaaa agcaccacac gtttttgtgt agtgctttcg ttctggtgga gattaccggg
     9661 atcgaaccgg tgacctcttg catgccatgc aagcgctctc ccgaacggta tcgaaacaca
     9721 ccccccacac gaaagtgcgg ggacaggctt aatatcgcgt tgatacgttc tatccaccaa
     9781 aaaggttcac agttgcatcc tgcttccagg aatcatgctc cgcctacaag gcaattttac
     9841 cacccaattt tcaagtgtgt caatgggttt tgctcagaga gaaggtcatt tacgagaaaa
     9901 gttttttctg acagcttact tagcgcaatt ttgattttac acatcaaagt tgcgcttttt
     9961 attttcccca aaagtattga caaggaggtt ttctcaacga tgccgatgta ttatcgctgt
    10021 tttttatcca tgaaccaacc gcatgaccct tgactacttc tacggacaga ctggagagct
    10081 tttctccttc taccgcattc caaaggctct ttttcaggag cagcggttcc agagcctgtc
    10141 cacggatgcc aaaaccctgt atggtatcct gctggaccgc atgagcctgt cggtgaaaaa
    10201 cggctggctg gacaagcaaa accgggtgtt catcatcttc acaatcgagg atgtcaagag
    10261 ggcattgtgt tgcgcagaca acaaagcaac caagctgctc cgggaacttg aaaagtttgg
    10321 tctgattgaa cgaaaacgcc gagggcaggg aaagccaagt ttggtgtatg tgaaaaactt
    10381 ttcggcagaa tcttcaaaag agagtgtcaa gaatcgtgat aatgacgatt cttgtggctt
    10441 caaaatcgcg tgtcaagacc ctgcaaaatc acggtgtaat aagactaaag agaatgatac
    10501 tgaaatgagt gagactaatc tcttctattc cgaagaatcg gatgggatga gtaagcgcgc
    10561 ccaactggaa gaatattttt cgcagtcttt ggaggtagac cttctgctcc ggctctgccc
    10621 ggatgatgag gacaccatct atcagatcgt agatttgctg gtggacacct gtgctaccaa
    10681 ccgcaagcta ctgcacatcg ccggggacga taagcccgcc gaggtggtac gtagccgatt
    10741 tatgaagctg aacgccgacc acatcaaatt tgtgttgaag tgccttgcag agaacagcag
    10801 cccaatcagg aacatgaagc aatacctgct cgcttctctg tacaacgcac cgaccaccat
    10861 gcagctttac tatcagaatc agaccaacca cgatttagcg aaacgggggt gataaaaatt
    10921 tccaaaaaag caaccacgat tgccattgtc aaccaaaagg gaggcactgg caaaacaaca
    10981 acctgtgaaa atctgggtgt tggccttgcc gccgagggta agaaggtcct acttgtagac
    11041 gctgacccgc agggttcact caccattagt atgggctggc agaagccgga cgaactgccc
    11101 gttactcttt ctaccctgat gcagaaagcc atgaacgacc agtgcattcc gcccggtgaa
    11161 ggtgtgctgc accatgcaga gggtgtagac ctcatcccgg ccaacattga gctggcaggg
    11221 ctggaagttg cccttgtcaa taccatgagc cgggaaaaaa tgctgaagca agtcttggac
    11281 agtgcaaagc aggactatga ctatattctg ttggactgca ctccctccct tgggatgctg
    11341 accattaacg cgctggcggc ggcagacact gctctgatac ccgtacaggc acagtacctt
    11401 tccgcgaaag gtctggaaca gcttttgcag accatcaaca aggtgcatcg gcagatcaac
    11461 ccaaagctga aaatcgaagg catcctgctg acgatgacag ataaccgcac caactatggc
    11521 cgacaaatcg acacgctgat ccggcaggca tacggaaagc acatcaaagt gttcggtcag
    11581 acgattcccc actccgtccg tgcagcggaa atcagcgcgg cgggtaagag catctttgtc
    11641 catgacccga aaggcaaagt ggcagaagcc tataaatctc tgacgaagga ggtgctggcc
    11701 gatgccaaaa agcagcgtaa acgccagtct gagcagctac gatgatattt tttccaccga
    11761 agaatcccgg caggaagaac agcgcgagca ggtgcagcag attccgattg gagagctgtt
    11821 tccattcaag aaccatccct tcaaggttct ggacgatgat tctatgagcg ataccgtgga
    11881 aagtgtcaag cagtacggtg tgctttcgcc gttgattgcc cgccctagac cgaagggcgg
    11941 ctatgaaatt atctccgggc accgccgtca acacgctgcg gagctggccg gactggaaac
    12001 cctgccggtc attgtgcgcc agatggacga tgatgctgcc ataatcctca tggtagatag
    12061 caatttgcag cgtgagcata ttctgcccag cgagagagcg tttgcgtaca aaatgaagtt
    12121 ggatgccatg aaaaatcaag gtacaaggtc agatttaact tcgacacaag ttgtgtcgaa
    12181 gttgcggagc aatgaaaagc tgggcgcaga gaataatcaa agtcgtgaga ctgttcgacg
    12241 tttcatccgt ctgaccaacc ttattccaga actgctggac atggtggata acaaaaccgt
    12301 gtccttcaat cctgctgtgg agctttccta tctttctcct gaacaacagc aggaagtgat
    12361 ccgggcaatg gatgataccc agaactttcc ttctgtctca caagcaaagc gtatcaagaa
    12421 gctggctcag gatggaactt ttacaacgga gacgatcgtt gccattatgg gcgaggagaa
    12481 aaagagcgag cttgatacgg tgaccatcaa aaatgacacc ctgagaaaat actttccccg
    12541 cagctatacg cccaaacaga tggaagatac catcatcaag ctgctggagc agtggcagaa
    12601 aaagcgtcag cacagtgaag aacgctgaca ggatatgaat tggaaagacc cggttgggtc
    12661 tttttcttta gaaaaaagga gaaaatgcct atgaaaaatg attctaatcc cattattcgt
    12721 tccgaggaag tcaccattga tatgcacatc tgtgcggcac tgtcggagag ccggagcagt
    12781 ggcgagatct attttgctgc catcgccccg gatatggaac tgacagtcat cacgctggac
    12841 gaggctcccg acattctgcc ctgctttgac gaggatgatg cgtacctgaa catccccgac
    12901 agctcgctgc tgctcagcta caacccggcg caggtgctga aactggcggg caagcactat
    12961 ctgaccggtc cggtcattct ggtgcgcacc aatatggatg gcgagttcat ctcgctgacg
    13021 atcgatcagg tctacctctt tcagaagtac ctgatgcgcc acagcgttac cctgatggct
    13081 gacggccaga agcttccctg catctgcatg gagtgaggtg tccttatgtc aaccagagaa
    13141 aaaagagaac agcggaaagc ccggaaagcg aggtttgctg caatgtatcc gggcttgtca
    13201 cacgatgaaa ttatcgagga gtgcatcaag gagctgaatc actatttcga ggttgggccg
    13261 gaagttgccc ttatcagtgc cgaaaaaggc gttcagtgtg tgccgtttga tgaatcacct
    13321 caaaagaagt ttccttactt tgagggaact tacgaagtct ttgacgttcc gcatacggat
    13381 ttccagattc gctatcagcc agagcagatt ctcgctgcaa acggaagaaa aatcctgacc
    13441 ggcacggcat ttctttgccg caaggaaaat gagcgttgtc ttatgcttcc gagccgatat
    13501 gaaaaggtcg atgtggaaga ttttattcgg gagcatctgt ttttctacga tgatgctgag
    13561 acgcgccatg ttggtgttga gctttcggag gttgcgtaat ggagttcgtg aaagactttc
    13621 tgatctatga agccggtgcg ctctgcgggt tctttatcgc agccctgatg aatgcggcac
    13681 gcgccggaca ggaaatcgcc atcaaatttg aggaggacaa gcatggagca ggagaagaac
    13741 accctgacgg tgctggaaat cgcaccgggg cattacccga agcaggtcga gatcgaccct
    13801 gacctgaaag ccttgcagca ggcagtcggc ggcaacatcg gtgccagcta cccgttcagt
    13861 gatcctgttg ccatcgtcta caacgatgag ggtaagctga tgggtctgcc gctgaaccgc
    13921 gccctgcggg acggaagcgg cgaagcctat gatgtggttg ccggaacctt tctggtggtc
    13981 ggtctgggtg aggaagattt tgcatctctc tccccggagc tggcgcagaa gtacgaggag
    14041 cattttcatc agccggaaga ttttatccag ctggggcatc ggatgatgat tgttcgtgta
    14101 ccggatgagg cagtcagccc ggaagatagc aaaactgcac cgccgaaaga tgccggacat
    14161 gaccgttgag cctgattctc tgctctggag actaactatt aaaagtcaag ccccaaaatg
    14221 aaaaaatccg ccaaccgac
//
