LOCUS       c00017_gnlPro..        14474 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DPOLIJOH_17.
ACCESSION   c00017_gnlPro..
VERSION     c00017_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:31:46
            Original ID  :: gnl|Prokka|DPOLIJOH_17
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14474
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14474
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2365:4474]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2366..4474
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14474
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14474
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             81..1967
                     /locus_tag="ctg17_1"
                     /transl_table=11
                     /translation="MVDTTSTSYIDKDVSSGRNYTYTVRCISADGKSFTSGYDSKGTTV
                     KYIAAPEISKLENVNGGVKITWNKVSGASKYRIYQKNSSDWFRVSDTTSNSIVDKSVDV
                     GTYTYTVRCISDDGKSFESGFNPKGSSIRYIQAPKILETNVVNGGIKVIWETENNTNYR
                     LYCKTEGKGWTKVCDTKTGVVTHKNLQPNKTYTYTVRAISSDAKKYLSGYDPVGMSAKY
                     VATPKISKTEVTYDGVKLTWNKVAGAEKYRVYYKDGEGWNKLADTTGNSYLDMGLVSRE
                     LSIKDNSVNGQYIYTVRCISSNGKVFQSGYDTKGSKANLGNECPEIVRVDSMHGGITVS
                     WTDVCEDNSKYRIYVKEKGSWKKLADTTNNYYTHKNVKAGQTYTYTVRCVSKDGKKFTS
                     IYNPSGVTFKYKTTDKTRDAYIDYLLKHESEWLPELKVGNVALAGVQFADLDFDGVPEL
                     IVQEAGDKEYYLNAKVYTFKDGKFSLVGFDDYRTYIPNQLTYFYDKSAKKYIINAVELS
                     TSNVDRYLERENYTLNYDGTVLVVRGYSSAHLALESRGLEYHYYNNTGRTTKQAYNATN
                     VSVLGNCVNAHMYSQFVHCSVDGYPKLWNNYSETQKKQHLLDSYNAFSYDKY"
     CDS             2082..2285
                     /locus_tag="ctg17_2"
                     /transl_table=11
                     /translation="MLSLGTSSCKLSQTTYTNYERGTRKKGSLKIITMLSSGISSCKLS
                     QTTYTNCGRGTRKKGSLKIKLP"
     CDS             complement(2366..3406)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_3"
                     /sec_met_domain="IlvN (E-value: 1.4e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.7e-61, bitscore: 196.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CEAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKLAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(3467..3958)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_4"
                     /sec_met_domain="ALS_ss_C (E-value: 7.7e-30, bitscore:
                     93.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRVNTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(3971..4474)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.4e-44, bitscore:
                     141.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRSKAILVADVGQNQIWCANNFRIREGRFLTTGGMGTMGYSIPA
                     AIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIKIIIMKNARLGMVRELQDKH
                     YGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENIIKGIVDSEKPFILVCDVHPD
                     TPSI"
     CDS             complement(4438..5517)
                     /locus_tag="ctg17_6"
                     /transl_table=11
                     /translation="LVIPVRLSAHFTIKFTTRALPTFLFVRNRTLLMRQAAMQDAVIVP
                     VFAWXXXXPGATNLITGIATAYTDSIPIVAITGQVRSDLLGRDVFQEADITGACEPFVK
                     HSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQENEIESFEYPESVNIIGYKP
                     NTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKLQKFAETTGIPVISTMMGIGV
                     MPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGDRAVAAPDQMSENTKVIHIDI
                     DPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMWSETVKNWKKDLYREPPVFDG
                     FVEXXXXQCSAQRQFLLPT"
     CDS             complement(5775..7016)
                     /locus_tag="ctg17_7"
                     /transl_table=11
                     /translation="LKKIFLLLVTTLFLLSLYGCNTSSSSNNSTEQTTVTDTDDLSLDS
                     DIETTELNHDFEIYNNGKKVDTLNLYGLFKQIDNGFIYSKINKDSPNEIEYYRYYLDKK
                     SSIKLGSIKDWTMQINDKAYVNNHLCFMASTGDITDEENRTLEFIDIDLNKNKMTTVFS
                     DKGGFPYDTVTGADNLVIITKVLDNGTSLELYDTETQKFKQLKYLEFDDKNSIGETIRK
                     VSIDKSTKTISLLVLDCISQNGASLKIETYDYDMNFLKSYDISNISDDSNELIQGVQVF
                     DFKNNYLFYQNFSITRCIGYIDSDKLKKSDISEDVDDTFSIVSASEDDSDTNLLYKRAE
                     SSSENNYIYLFDTTNKTMKETKFNIEEKGYTIGGISRIGKDNLMIMMSPDNADKKSDLN
                     SRIYFTKLSDLNFQ"
     CDS             complement(7212..9308)
                     /locus_tag="ctg17_8"
                     /transl_table=11
                     /translation="MRYKYQLDNLNCAHCAGKIEAKIAETNGFEDVSFNFATKLLNFKS
                     EKQNPVSEIQAICDSIEDGVTVVDKTPKDDITTKPEPEITKKKINHDTIFLAISIVLAV
                     VSEILHLILDGVTAVHYVVLAACFVATLLSGYKVFIKGAKNILKLRIDETTLMAVAVIA
                     AFCLGDFVEAAMVTILFSIGEIFEDRAVDASRRDIEKLANIRPDTATIIVDGAEQIVPA
                     ESVEIGSIIEVKPYERVPLDGIIIKGKTTLDTSALTGESLPVDAGEGSEVLSGAINGSN
                     LITVKTTKHFGDSTATRILQLVEDAAAQKGNSEKLISRFASVYTPVVVLIAAAIAVIPP
                     LCGLGAFSEWLYRALVCLVASCPCAIVISVPLSYYSGIGAASEVGVLIKGGKYIEALAK
                     ADTFVFDKTGTLTSGKLSVNKVNTVGSYSADEVLALAAASEKYSAHPIASAIREKANGL
                     ELPELSDYSESAGHGTSAVYNGKTIQCGGSKILSDEQKKIANKDDSVFVIYDGQLIGSL
                     NVSDTVRPEAKEVISQLKALGVKNTVMLTGDRQQPAENVKNELGLSECHAELLPAQKLE
                     LFKGLKSKSKGACFVGDGINDAPVLSASDCGIAMGFGSEAAIEASDAVLASGTLKQLPK
                     AIKIARSVINTVKGNIIFALSIKALVIILAAFGLAQIWMSVIADTGVSVVCVLIAARLL
                     KKKY"
     CDS             complement(9321..9638)
                     /locus_tag="ctg17_9"
                     /transl_table=11
                     /translation="MENKEKTTTPEMPDIDVLFELADLFKVFGDSTRLRIMYTISENEM
                     SVLNIAEALSMEQSTISHQLRVLRQNKLVRVRREGKQIYYSLDDDHVKRIIEMGLDHVL
                     E"
     CDS             10374..11666
                     /locus_tag="ctg17_10"
                     /transl_table=11
                     /translation="LEKFVVTGGKPLSGEVTISGAKNAAVAIIPAVILCDEPCQIENIP
                     NISDVSLISRILQQMGANVRRINRSSLYIDPTKIRTCNAVTDLVRGMRASYYLLGALLG
                     KYGKAKVALPGGCNFGVRPIDQHLKGFEALGATTQLVDGAIIEAECDNLVGTHVYLDVV
                     SVGATMNIMLAASKAKGQTIIENAAREPHIVDLANFLNSMGADVRGAGTDVIKIRGVEY
                     LHGITYSIIPDQIEAGTYMCAAAATRGCITVKNITPKHLESISAKLREMGVKITEYDEA
                     LKVDASSAPLKRCNIKTMPHPGFPTDCQPQFAALLMSVPGTSIINENVWDNRYQYVSEL
                     IRMGAQISVEGRLAIIEGGVPLTAAPVKATDLRAGAAMIIAALEINGTTEISNIQFIER
                     GYEDVVEKFRGLGADIKKVYFTGDNEQELGA"
     CDS             11906..12577
                     /locus_tag="ctg17_11"
                     /transl_table=11
                     /translation="MHANGLDMGSIGAVFITHEHTDHCSALRVLAKRYGFKVYSSLGTL
                     NALRAGNKLDPNTDADVITDEVVIGNMRVQRIDTPHDAAESCCYRVTAPDGKSALIATD
                     MGVMLPDVRTAAEQSDFVVLESNHDINMLKNGFYPYPLKQRILSNRGHLSNEACAKELV
                     NLVEKGTLRLMLGHLSEENNTVPLAMSTSVDLLTSNGMKYKSDYSLDVAPSVSTTKAII
                     F"
     CDS             12599..13084
                     /locus_tag="ctg17_12"
                     /transl_table=11
                     /translation="MIKINIICIGKIKEKYFTDAIAEYAKRLTAFCKFNIIELSEERIK
                     SNIPNRSQIDEVIFSEGKRIMQKILPSDYVVAMCIEGKPMSSEELSKLIDNASVSGKST
                     VDFIIGGSYGLDESVKKRADVRLSMSRMTFPHQMARMILSEQIYRAFEISSNGKYHK"
ORIGIN
        1 ttgttaatta ttcgtggtgc acagatatct tctctcctaa tcactggtcg tcagagtctg
       61 tggtgtatgc gaggactcga atggtcgata caacttcaac atcatatatc gacaaggatg
      121 tttcatcggg caggaattac acctatactg taagatgtat ttctgctgac ggaaagagct
      181 ttacaagcgg ttatgattca aaggggacaa ctgtaaaata tattgccgcc cccgaaattt
      241 caaagcttga aaatgtaaac ggcggtgtga aaattacatg gaacaaagta agcggtgcat
      301 caaagtatag aatttaccag aaaaattcgt cagattggtt cagagtatca gatacgactt
      361 ctaattctat agttgataaa tctgttgatg tgggaaccta tacttatacc gtgaggtgta
      421 taagtgatga cggaaagagt tttgagagtg gatttaaccc aaaaggctca agtatcagat
      481 atattcaagc tcctaaaata cttgaaacca atgttgtaaa tggcggtatt aaggtgattt
      541 gggagactga aaacaataca aattacagat tgtactgcaa aacagaaggt aagggctgga
      601 caaaagtatg cgataccaaa acaggtgttg tgacacataa aaatttacag ccgaataaaa
      661 cctatacata cactgtaaga gcaatcagtt ccgacgctaa aaagtatttg agcggttatg
      721 accctgtggg aatgagcgca aaatatgttg ccacaccgaa aatttcaaaa actgaggtca
      781 catatgacgg cgtaaagctg acatggaaca aggttgcagg tgcagagaag taccgtgtgt
      841 actacaaaga cggtgagggt tggaacaaac ttgccgatac aacgggtaac agttatcttg
      901 atatgggact tgtatcaaga gaactaagca taaaagataa ttccgtaaac ggtcagtata
      961 tttatactgt tcgttgcatt tcaagtaacg gcaaggtttt tcagagcggt tatgatacaa
     1021 aaggttctaa ggcgaattta ggcaatgaat gtccggagat tgttcgtgtt gactcaatgc
     1081 atggcggaat tacagtttca tggacagatg tttgcgaaga taattcaaag tatcgtattt
     1141 atgtaaaaga aaaaggttcg tggaaaaagc ttgctgatac aacaaataat tattacactc
     1201 ataaaaatgt aaaagcagga cagacctaca cttataccgt aagatgtgtt tctaaggacg
     1261 gcaagaaatt tacaagtatc tataatccgt caggtgtgac atttaagtat aagactacag
     1321 ataaaacaag agatgcatac atagattatc tgctcaagca tgaatcggaa tggttacctg
     1381 aactcaaggt aggaaatgtt gctttggctg gtgtgcagtt tgccgatctc gattttgacg
     1441 gtgttcccga gcttatagta caggaagcag gagataagga atactatttg aatgcaaagg
     1501 tgtatacctt taaggacgga aagttttcgt tagtcggatt tgatgattat agaacttata
     1561 tcccgaatca actgacttat ttctatgaca aatctgctaa gaaatatata attaatgccg
     1621 ttgaattgtc aacctcaaat gttgaccgtt atcttgaacg cgaaaactat acattgaatt
     1681 atgacggcac agttttggtt gttcgtggat actcttctgc tcatttggct cttgaaagtc
     1741 ggggattgga ataccattat tacaataata ccggaagaac aacaaaacag gcatataatg
     1801 ccacaaatgt gagtgtactc ggtaattgtg taaatgcaca tatgtacagt cagtttgttc
     1861 actgttctgt tgacggctat ccaaaacttt ggaataatta tagtgaaaca cagaagaaac
     1921 agcaccttct tgattcatat aacgcttttt cttacgacaa atattgattg tcaaaattga
     1981 taagttttaa ctgcaaaagg gttcagccgt aaaaagctga acccttttat tgcacaacaa
     2041 aaaacggttc agccaaattg actgaaccgt taatctgtac tatgttaagc ttgggaacaa
     2101 gtagttgtaa attatcacaa actacctaca cgaactacga gcgaggtact cgcaaaaagg
     2161 gtagcttgaa aattataact atgttaagct cgggaataag tagttgtaaa ttatcacaaa
     2221 ctacctacac gaactgcggg cgaggtactc gcaaaaaggg tagcttgaaa atcaagctac
     2281 cctaaattcg tactatgtaa tgctcgggtg acagaaattt gaatatatca aactaacttc
     2341 acgaactacg agcgaggtac tcgcattagt tgttgatgag cttatcttcg tcagaccagc
     2401 tgtagagctt tctaacttcc ttaccgaata cttcggcagg agcttcggca gcgagctttc
     2461 tcatagcctt gaagtgaacc tgtgaaccgg catcgctcat gtcaaggagg aagtccttag
     2521 caaatgtacc gtcctgaatg tcagaaagaa cctttctcat agccttctta gtatcctctg
     2581 tgatgatctt tggacctgtg atgtagtcac cgtactcagc tgtgttagag attgaatatc
     2641 tcatgcctgc aaaacctgac tgatagataa ggtcaacgat gagcttcatc tcatggatac
     2701 actcaaagta tgcgtttctt gggtcataac cagcttcaca aagtgtttca aaaccagcct
     2761 gcatcagtgc gcaaacacca ccgcagagaa cagcctgctc accgaagagg tctgtttctg
     2821 tttctgttct gaatgttgtt tcaagaacgc ctgctcttgc accgccgata ccgagtgcat
     2881 atgcaagtgc gagatcctta gcctgacctg tagcatcctg ctcaacagca acgaggcaag
     2941 gtacaccctt accaacctga tactctgaac gaactgtgtg acccggtccc ttaggagcta
     3001 ccattgtaac atcaacatcc tttggaggct tgatgcaacc gaagtgaatg ttaaagccgt
     3061 gagcgaacat aagcatattg cctgcttcga ggtttggctc gatgtcgttc ttgtaaagag
     3121 ctgcctgctt ttcatcgttg ataagaatca tgatgatgtc agcctgcttt gcagcctctg
     3181 ccgatgtata taccttaaag ccctgtgcct cagcctttgc ccagctcttg ctgcctttgt
     3241 aaagaccgat gattacatcg caacctgaat ccttgaggtt gagagcgtgt gcatgaccct
     3301 ggctgccgta accgataata gcaattttct tacccttgag aaggtcaagg ttgcaatctg
     3361 actgatagta gattggtgct gtcatgtttt ttgtgtagtc tttcatatta aagtcctcct
     3421 taccgcaaac gcggcatata aattaaaata tatgctaact gtaagattaa acggaaaccg
     3481 aagctgtgcc tctgtcaatg gcaacagtac ctgttcttac aatctcacgg ataccataag
     3541 gcttgagtaa gtcaacaagc gtgttgacgc ggcttgcaca ttcgcagtac tcaacggtaa
     3601 ctgacgaagg ggatacatca acgattttcg cctgcataat ttcaaccgtt ttgacaattt
     3661 cggctctttt tgaggcggcg cagtgaacct tgattaaaac aagctcacgg ctgataaatt
     3721 cgccctcgtt aagccttttt accttgatga cgggaatgag cttgttgagc tgtttttcaa
     3781 gctgttcaac aatgtactcg tcaccgtttg caacgattgt gattcgggaa accgacgggt
     3841 cctgagtaac acctactgca agtgagtcga tgttaaaacc tcggcgagag aaaagtcccg
     3901 aaatttttga aagaacgccc gcctgatttt caacaagtat tgataatgta tactgcattt
     3961 tatcacctca ttaaattgac ggagtgtcgg ggtgaacatc gcaaacaaga atgaacggtt
     4021 tttccgaatc aacaataccc ttgatgatgt tttcggcttc cttgtttgaa tgagcctctg
     4081 catggtcaat gccgtaagca tcggcaatct tcaagaagtc gggatcaccg ttgagaattg
     4141 ttgcagagtg tctgccaccg tagtgtttgt cctgaagttc acgaaccatt ccgagtcgtg
     4201 cgtttttcat aatgatgatt ttaattccga gctgattgcc tgcaatagtc gcaagctcat
     4261 taagccccat ctgaaaactg ccgtcaccgc agattacaat aacatcacgg tcgggtcttg
     4321 caaactttgc accgattgca gcgggaattg agtaacccat tgtacccata ccgcctgttg
     4381 tgaggaatct gccctcacga atacggaagt tgtttgcaca ccagatttga ttttgtccta
     4441 cgtcggcaac aagaattgcc tttgagcgga acattgcnnn nnnnnnngct caacaaagcc
     4501 gtcaaaaacg ggaggctcac ggtaaaggtc ttttttccag ttctttacgg tttcgctcca
     4561 cattgttgta accttgtaat cgccgatgct gtcaagcagc atattgatga catttttcat
     4621 atcgcctaca atcggaattt ctgttttaac attcttaccg atttcagcag ggtcaatgtc
     4681 aatgtgaatt acctttgtgt tttcactcat ctggtcggga gccgcaacag ctctgtcacc
     4741 gagtcttgca ccgcatacga ttacaaggtc ggcttcgtga agagcacggt tggcaacagc
     4801 cttgccgtga gtgccgagca ttccgagata aagctcatgc tcgctgggca taacaccgat
     4861 gcccatcata gttgaaataa cggggatacc cgtagtttct gcaaattttt gaagtttaag
     4921 cttgatacca gaactcagca cgccgccgcc tgatacgata acaggacgct tgcttgcgtt
     4981 gatggcctca acagcctttt taacctgaat tgcgtgtccc ttagtgttcg gcttgtaacc
     5041 gataatgttt acgctttcgg gatattcaaa actttcaatt tcattttcct gaatatcaac
     5101 gggaatgtcg ataagtacag gaccgggtct gccggttgag gcaatatgga aagcctcttt
     5161 gaaaactctc ggaaggtctt ctgttttgct gacgagataa ctgtgcttta caaacggttc
     5221 acaagctccc gtgatgtcag cttcctgaaa gacatctctg ccgagaaggt cggaacgaac
     5281 ctgacctgta atggcaacaa tcggaataga gtccgtatag gcggttgcaa tgcctgtgat
     5341 gaggttggtt gcaccgggac nnnnnnnnnn ccacgcaaac accgggacga ttactgcatc
     5401 ttgcatagcc gcttgccgca tgagcagcgt tctgttcctg acgaacaaga atgtgggtaa
     5461 tgctcgagtc gtaaacttta tcgtaaaatg ggcagatagc cgcaccggga taaccaaaga
     5521 ctatgtcaac gccctcggct tccaaacatt ttaccataat ttcagcaccg ctgatcatta
     5581 tgttttgtcc ctcctatcct ttttattgtg agcaaaaggt gttttgtaac attaaatata
     5641 cctttttact ttaccgctaa ttatacaata aataccttaa aaagtaaaga gcagtattgc
     5701 ccataaatta aattttttgc aggattttga cagataattt gcaaaatgaa ttttaattga
     5761 tttttaccgc ctgtttactg aaaatttaag tcgcttaatt ttgtaaagta tattcttgaa
     5821 ttaaggtcac tttttttgtc tgcattatca ggggacatca ttatcatcaa attatctttt
     5881 cctatccgtg atataccgcc tatagtgtac cctttttctt caatattaaa ttttgtttct
     5941 ttcattgttt tgttggttgt atcaaaaaga tatatgtagt tattttctga acttgattcc
     6001 gccctcttat acaataaatt tgtatcactg tcatcttcag atgcggatac tattgaaaaa
     6061 gtatcatcta catcttctga tatgtcggat tttttcagct tatcgctgtc tatatatcct
     6121 atacatcttg ttatgctgaa attttgatag aatagataat tgtttttaaa atcaaaaacc
     6181 tgtacgccct gaattaattc gtttgaatca tctgaaatgt tggaaatatc atagcttttg
     6241 agaaaattca tatcatagtc ataagtttct atttttaaag aagctccgtt ctgtgaaatg
     6301 caatccaaaa ccaaaagaga gattgttttt gtacttttgt caattgaaac ttttcttata
     6361 gtttccccga tactgttttt atcatcaaac tctaaatatt ttaattgctt gaatttttga
     6421 gtttcggtat catacagttc caaagaagta ccgttgtcta gcacttttgt gattatgaca
     6481 agattgtctg ctcctgtaac agtgtcatat ggaaatccgc ctttgtcaga aaatacagtc
     6541 gtcattttgt ttttattaag gtcgatatca ataaattcaa gagttctgtt ttcttcgtct
     6601 gtaatgtcgc ccgtgcttgc cataaaacat aagtgattat ttacatacgc tttatcgtta
     6661 atttgcattg tccagtcttt tattgagccg agttttatac tgctcttttt gtctaaatag
     6721 tatctgtagt attctatttc atttggagag tctttattga tttttgaata tatgaagccg
     6781 ttatcaattt gtttaaataa gccgtaaaga tttaaagtat ccaccttttt gccgttattg
     6841 taaatttcaa aatcatgatt taattctgtt gtttcaatat ctgaatcaag agataaatca
     6901 tctgtatccg ttacggttgt ttgttcagtg gaattattgc ttgatgaaga agtgttacat
     6961 ccatataatg aaagtaaaaa taaagtggtt actaataata aaaatatctt tttcaaatta
     7021 atctctccga agtttattta tcagttacaa gcactgacaa aaacattata atttatataa
     7081 ttataaaagt caatgatttt aaaatactat aatataagat tatgtttaga aaaattttgg
     7141 caaatgaaag caccgtgaaa cttgtgaaag ctcacggtgc tttatcataa atgatatgat
     7201 ttgtaaaaaa atcaatattt ctttttgagg agtcttgcgg ctatgagtac gcagactacg
     7261 ctgacgcctg tgtcggcgat aacagacatc cagatttgtg caagaccgaa tgcggcgagg
     7321 ataattacaa gagccttgat tgagagggca aagatgatgt tgcccttgac agtgttgata
     7381 acacttcttg caattttaat tgcctttgga agctgtttga gtgtgcctga tgcaagaact
     7441 gcgtctgacg cttcaatagc ggcttcactt ccgaatccca ttgcgatacc gcagtcgctt
     7501 gccgaaagaa caggggcatc attgatgccg tcgcccacaa agcaagcccc cttagatttt
     7561 gatttcaagc ccttgaaaag ttcaagcttt tgagcaggga gaagctctgc gtgacattcg
     7621 gaaagtccga gttcattttt aacattttcg gcaggctgtt gtctgtcgcc tgtgagcatt
     7681 accgtgttct tgacaccgag cgctttaagc tgtgagataa cctcttttgc ctcaggtctt
     7741 accgtatcgc tgacattgag cgaaccgata agctgaccgt cataaattac gaaaacagaa
     7801 tcgtctttgt ttgcaatttt cttctgctcg tccgaaagaa tctttgaacc gccacactga
     7861 atagttttgc cgttataaac tgcgcttgtt ccgtgaccgg cactttcgct gtagtcggaa
     7921 agctcgggaa gttcaagacc gtttgccttt tctctgattg cggatgcaat cggatgagca
     7981 gaatattttt cgcttgcagc ggcaagagca agaacttcgt cagcactgta tgaaccgacc
     8041 gtattaacct tgtttacgct gagcttgccg cttgtgagtg tgcctgtttt atcgaatacg
     8101 aatgtgtctg cttttgcaag agcctcaata tattttccgc ccttgatgag tacaccgact
     8161 tcggatgccg caccgatacc cgaatagtag gagagaggta cggaaataac aatagcacac
     8221 ggacatgacg ctacaagaca aacaagcgca cggtagagcc attcgctgaa tgctcctagt
     8281 ccgcaaagcg gaggaattac tgcgattgca gctgcaatga gtacaacaac cggtgtgtaa
     8341 acagaggcaa atcttgaaat aagcttttcg ctgttgccct tttgagcggc ggcatcttca
     8401 acaagctgaa gaatccttgt tgcggtactg tcgccgaaat gctttgtggt tttgacagta
     8461 ataaggttac tgccgttgat tgcgccgctg agtacctcac tgccctcgcc tgcatcaaca
     8521 ggaaggcttt cgcctgtgag agccgatgtg tcgagagttg ttttaccttt aataataatg
     8581 ccgtcaagcg gaactctttc gtatggcttg acttcaatga tacttccgat ttcaacgctt
     8641 tcggcaggaa caatctgttc cgcaccgtca acaataattg ttgctgtatc gggacgaatg
     8701 tttgcaagct tttcaatgtc acggcgggat gcgtcaactg ctcgatcctc aaaaatttca
     8761 ccgatagaaa agaggattgt taccattgcc gcctcaacaa aatctccaag acagaatgcc
     8821 gcaattaccg caacagccat aagcgttgtt tcgtcaattc tcagctttag aatgtttttt
     8881 gcacccttga tgaatacctt gtaacccgaa agtagtgttg caacaaaaca cgctgcgagt
     8941 acaacataat gaacagccgt aacaccgtca agtataaggt ggagaatttc ggacactaca
     9001 gcaagtacaa ttgaaattgc aaggaagatt gtgtcatggt tgattttctt tttcgtgatt
     9061 tcgggttctg gctttgttgt gatatcatct ttcggagttt tgtcaacaac ggttacaccg
     9121 tcctcaatgc tgtcgcagat tgcctgaatt tcggaaacag gattctgctt ttcgcttttg
     9181 aaattgagaa gttttgtcgc aaaattgaag ctcacatcct caaagccgtt tgtttctgca
     9241 attttagcct caatcttgcc cgcacaatga gcgcagttga gattgtcaag ctgatatttg
     9301 tacctcatat gtctccctcc ttattcaaga acatggtcaa gtcccatttc tatgattcgt
     9361 ttcacatggt catcgtcaag actgtaataa atctgctttc cttcacggcg aacacgcacc
     9421 agcttgtttt gccttaacac acgcagttgg tgggaaattg tgctttgctc catgctgaga
     9481 gcttcagcaa tgttgagcac cgacatttca ttttccgaaa tggtgtacat aatgcgaagt
     9541 cgggttgaat caccgaaaac cttaaaaagg tctgcaagct caaatagcac atcaatgtcg
     9601 ggcatttcgg gagtggttgt tttttctttg ttttccatag gcgtcccctt taattttctc
     9661 tcaggttaaa agttatactt gaacatatga agatatgctc atatgttaat tataatatag
     9721 cattcccttt ttaaaaagtc aatagacaca cacgaaaaaa tgtaatgttt ttcaagtttt
     9781 tttgccccaa agtttcactt gtttattgtg tccgtttgga aagtatatat agtatagtat
     9841 agaaagttaa ttttaaattt gaaaaaagaa gattgaaggt gtaaaattat cataggaata
     9901 acggaacgat atttttctgt gttcaatttg aattgtaaaa tgctcagatg cctgatgata
     9961 acacgaaaat aacacttgtt tcaatttgta ataattttac aaaaaatcgc tttgattaat
    10021 tacttctttt taggaaaaaa cggttttaaa aagcatggtt ggttatatta aaaacaaaaa
    10081 aagcaacaaa ttaataattt gagtacaact tgcccaaaaa tagattacag ttttattatt
    10141 ccgttgactt tactacaatt ttgtagtatc attttctgta agagaattgt taaattacat
    10201 ctgcgtaacc gagtgggttc gtttttaata aaatgtaaca aattagttct cattatgaat
    10261 tttagattcg tataattttt gatttttact tatacactat atagatatac attttcagat
    10321 atttagctta tttagttaaa agtatcttct acacattaat tggggtgtaa caattggaga
    10381 agttcgtagt taccggcgga aagccattat cgggtgaagt gacaatcagc ggtgcgaaaa
    10441 atgcagccgt tgcaattatt ccggcagtta ttctttgtga tgaaccgtgc cagattgaaa
    10501 atattcctaa catcagcgat gtatcactta tcagcagaat tcttcagcag atgggtgcta
    10561 atgtaagacg aatcaaccgt tcgtccttat atattgatcc tacaaaaatc cgcacatgca
    10621 atgctgtgac cgaccttgta agaggtatga gagcgtcata ttatctcctc ggcgcacttt
    10681 tgggcaagta cggcaaggct aaggtggctc ttccgggcgg ctgtaacttt ggcgtgcgtc
    10741 cgattgacca gcatcttaaa ggctttgagg ctctcggtgc gacaactcag cttgttgacg
    10801 gtgcgattat agaggcagaa tgcgacaacc ttgtcggtac acatgtgtac cttgatgttg
    10861 tgtccgttgg tgcaacaatg aacattatgc ttgccgcatc aaaggcaaag ggacagacca
    10921 ttattgaaaa tgccgcaaga gaaccgcata ttgttgacct tgcgaacttc cttaattcaa
    10981 tgggtgcgga tgtcaggggc gcaggtacgg atgttatcaa aatccgtggc gttgagtatc
    11041 ttcacggcat tacttattcg attattcccg accagattga ggcaggaaca tatatgtgtg
    11101 ccgccgccgc aacaagaggt tgtattacgg taaagaatat tacaccgaag catcttgaat
    11161 caatcagcgc aaagctgcgt gagatgggtg ttaagattac ggaatatgat gaggctctca
    11221 aggttgatgc gtcatctgct ccgctaaagc gctgtaacat caagacaatg ccgcatcccg
    11281 gcttcccgac agactgtcag ccgcagtttg ccgcattgct tatgagcgtt cccggaacaa
    11341 gcatcatcaa tgagaatgtt tgggataatc gctaccagta tgtcagcgag cttatcagaa
    11401 tgggtgcgca gatttctgtt gagggcagac ttgcaatcat tgagggcggt gttccgctca
    11461 cagcggctcc cgttaaggca accgaccttc gtgcaggtgc tgctatgatt attgccgctc
    11521 ttgaaattaa cggtacaaca gagatttcaa atattcagtt cattgagcgt ggatatgaag
    11581 atgttgttga aaagttcaga ggacttggtg cagatatcaa aaaggtgtat tttacaggag
    11641 acaacgagca ggagctcggt gcctgactaa aatttaatta gaaatcaaag ccgttttctt
    11701 tgtgagaacg gcttttttgt gagataattt acaaatttta aaatttgtgt tatcatattc
    11761 gttatactaa agataaggat tgattgtttt ggcaagagca gtaccgctgt tcagcggaag
    11821 taagggtaac agctactaca taggttcggc aagcgaaggc gtactgattg acgcaggtcg
    11881 ttcatgcaag cagattgaaa atgccatgca tgcaaacgga cttgatatgg gcagtatcgg
    11941 ggcggttttt ataactcacg aacacactga ccattgcagt gcgttgcgtg tgcttgcaaa
    12001 gcgttacggc tttaaggtgt attcaagtct tggtacgctc aatgccttga gggcaggtaa
    12061 taagcttgat ccaaacacgg atgcagatgt tataactgac gaggttgtaa tcggcaatat
    12121 gcgtgttcag cgaattgaca ccccccacga tgcggcggaa agctgttgtt accgtgttac
    12181 tgctcccgac ggaaaatccg cacttatagc aaccgatatg ggcgttatgt tgcccgatgt
    12241 cagaactgcc gcagagcaga gcgattttgt tgtgcttgag tcaaatcacg atattaatat
    12301 gctcaaaaac ggattttatc cttatccgct aaagcagaga atcctttcaa acagaggaca
    12361 tctttcaaat gaggcatgtg caaaagaact tgttaacctt gttgaaaagg gaactttaag
    12421 acttatgctc ggccatctca gcgaagaaaa taataccgtt ccgcttgcaa tgtcaacatc
    12481 cgtagacctg ctcacatcaa acggaatgaa gtacaaaagc gattattcgc ttgatgttgc
    12541 tccgagtgta agcacaacaa aagccatcat cttttaacct taaacaaaca agaggaatat
    12601 gattaagatt aacataattt gtatcggcaa aatcaaggaa aaatatttta ccgacgcaat
    12661 tgcagagtat gcaaaacgct tgaccgcatt ttgtaaattt aatattattg agctttcgga
    12721 agaacgcatt aagagcaaca taccgaatag gtcgcagatt gatgaggtta ttttctctga
    12781 gggaaaacga atcatgcaga aaattttgcc ttcggattat gttgttgcaa tgtgtattga
    12841 gggaaagcct atgtcgagtg aggagctttc aaagctgatt gacaatgcgt ccgtaagcgg
    12901 aaaaagcacc gttgatttta ttatcggcgg cagctacggg cttgacgaat cggttaaaaa
    12961 acgggcagat gtccgtcttt caatgagcag aatgaccttc cctcaccaaa tggcaagaat
    13021 gattttaagc gaacagattt accgtgcgtt tgagatttca tcaaacggta aatatcacaa
    13081 ataatttacg gagttactat ggcgcttgac ggaatttttt taagacatat taaaagtgaa
    13141 atagaaaaag aggctctcgg tgcaagggtg tcgcagattt atcagccgaa cagagaggag
    13201 cttgtgttcg ggttgagaac attttccggc aacaaaaagc tgttgctttc tgcacgagca
    13261 aattcaccga gagtgaactt ctgttcgtca acacccgaaa atcctgcaca acctccgatg
    13321 ttctgtatgc ttttgcgaaa aagaatcggc ggcggaaagc ttgtgggact tcgccagaac
    13381 ggttgcgacc gtgttcttat gctcgatttc gagtgcgtga acgaactcgg cgatactgtg
    13441 atgataactg ttgtatgcga aattatgggt atgtacagca acataattat tgtcgattca
    13501 aacggcgtca tcattgattc actcaggcgt gtagatctta caatgagcag taaaagactt
    13561 gtactgccga atataaaata tgaacttccc gaatcgcaga acaagctgaa tctgcttaaa
    13621 tgttcggtgc ttgatgtgtg tacagccgta aaaaatcttg acacggaaat gccgcttaac
    13681 aaggcgctgt taaggacaat tgagggtgtt tctccgattg tatgccgtga gattgaatac
    13741 aaggttatgg agggcgcaac aaacagaatt gagggtgtgc tttttgaccg actcgcagtt
    13801 gaaattgaaa agctgaaaag cgtttgcagc gattgttcgg gcaagcctgt tgtggtttat
    13861 cgtgaggacg gcaagcctat ggacttctgc tttatgaatg ttgagcagta cggcgatttt
    13921 gcaaaggttg agagtaagga aagcttctcc gatttgcttg acggattcta tgaggctcgt
    13981 gacagtcgtg acagaatgag ggtgaaatca caaagcctta caaagctttt gaacaacaca
    14041 cttgaaaggc ttgcacgaaa aattgcaaag cagaagagtg agcttgaacg ctgtgcagac
    14101 cgtgagcatc ttcgcatatg cggtgacctt ttacaggcaa atatctatcg cattgagcgt
    14161 ggtgcggagt atgttgatgt tgaaaacttt tacgatgaga acaatgcaat tttacgcata
    14221 aagcttaatc cggcaatctc accttcggca aatgcccaga agtattacaa ggattaccgc
    14281 aaggctaaaa atgccgaaat tatgctcaaa gaacagcttg aaaagggcag ggaagagctt
    14341 gattatatta actcggttct cgatacggtt gaccgtgcgg aaaatgaaaa agaccttgca
    14401 caaattcgtg aggaacttac cgagcagggc tatctcaagg ttcaaaaggg caaaaagccc
    14461 cgtcagacaa cttt
//
