LOCUS       c00032_gnlPro..        15064 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DPOLIJOH_32.
ACCESSION   c00032_gnlPro..
VERSION     c00032_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:31:46
            Original ID  :: gnl|Prokka|DPOLIJOH_32
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2020
            Orig. end    :: 17084
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15064
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[12020:15171]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13151
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15064
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15064
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             40..915
                     /locus_tag="ctg32_2"
                     /transl_table=11
                     /translation="MSKKIKNMLSILFVAVLTVSAFCIPASAAEDNLTISISTDEKDSV
                     TAKVGDTVKYAIYMTDTKEEVIGAAMSFFYNDEYLKLNADSINCESFKTAIGNPKLKNF
                     YTFTWTDVQNPVKLNGDKALVSAEFKVLKGGKTDLSYFISDMYGDDMTYLKSYKITCKL
                     WVNGKEVEDSAVPIVNNDTANSEKIQGDFVNYIDGMGEENSPNKDDHKSVVVEKKYIST
                     QQNSQVVDVTKVVESSANGSGSNTTLIIIIAIVVVLIAAGAIIFVKKKDEKKKKSADNN
                     AMSDDADADK"
     CDS             1098..2168
                     /locus_tag="ctg32_3"
                     /transl_table=11
                     /translation="MSKKLISIIVSCALVLSLALVGVIGVSAAIDTNGRYVPSEGVEET
                     HRVYFLMPESWKSVKFNANDAGAYWWNGSDAGNSLDGTSVGVAWPGYKMQVENAENNIF
                     YLDLPTDVPNLDFNNYLNGGLRTEDAATGKVTYEFSEEQFKAAKQTADVSCQYYSEGDN
                     EYYDNLLDGEFWTKAQEAFDGNDKTFLGKFADNFFEDPDWGISMYLTNMIYVIDPSNTS
                     VSVTGKETYAGEFYFYYGLNEETGKYEYGSLPNYDMAKEAGLVQSVDKNATPDQAATTA
                     PSSDKKDDNKTDSTKNTVPTAGQNPTSSANAVSTADTAKSTDNSAVQTGATTAAAVLAV
                     LLVAGGAVLYTRKRFE"
     CDS             2443..4047
                     /locus_tag="ctg32_4"
                     /transl_table=11
                     /translation="MSKKVISLLLAVMLTAAMIVVAAISVSADTDDEGSYVPSEGTETY
                     HIYFCKPDDWENKYTSDAGVYWENGSDTPSAWPGYSARNADIKNVYCSDVPTDADKVIW
                     NNALKGTDDPTNPEYKLAYRTTDINFKGYDKGESDYYPNGVESFDNMIYIINPEFTSEN
                     DKDELIFAGEWFYYYGNGEYGNAPKKADLKAGDYYGKDGVFPTEYNPTGEETTAESTTE
                     VVTESETTESATDAPVATEGTTSSAESSLALTVNATSNYFPMASAKYNAVTNQVTVTYI
                     MQSPKNVLDTQWHISYDPSILSVADVNTAKSVCPTMDGRGVYVNFKNKSEGVGYVKFGA
                     SNLGLYDFSEKTLFATVVFDVKDVSKVAPVSTTVDLVVEVLRVSEVNPDTEMTDGSKEV
                     ILVDKEVVKKAPVAAAVKNDLSTELTPSTYAEPTTAEPSTAESSTEATKATEETQESTK
                     DTIAPVTSQDATSVTQPVTKKISSTSDTPDTSDNGGNNNANAAVQTGEAPLAVVILSLL
                     IGSTCVMFVLRKKEEIL"
     CDS             complement(4000..4242)
                     /locus_tag="ctg32_5"
                     /transl_table=11
                     /translation="MLAPVVCVQVRLPELTDFTDYETAPLFTVELFFCIFIRILNHNHS
                     TERGLTFVWSALLIISLYQPLKDFFFLTKNEHYTS"
     CDS             complement(4193..4381)
                     /locus_tag="ctg32_6"
                     /transl_table=11
                     /translation="MAKCEFCGKDVKFGIKVSHSHRRSNRTWKPNVQRVKAIVDGSPKR
                     VYACTRCLRSGKVTRAN"
     CDS             4581..5279
                     /locus_tag="ctg32_7"
                     /transl_table=11
                     /translation="MLSLLLNGIRNGNLDFGSVIAEILAVLVIIFLILPFHEWAHAFTA
                     SLLGDKAVKGRGRLSINPLSHIDPMGALCMLLFGFGWAKPVPIDPRNFKNPKVGMAITA
                     IMGPIANIVAAFVGLLIYYPIILFTGAFPLSTIGGYVVQFLSFYISCNVGLAVFNLIPI
                     PPLDGSKVLFVFLPDKAVEFFYRYQMYFFIGLFVLLYVGILNTPINWLSNQILDFISWL
                     ASLPYMPFVG"
     CDS             5324..6097
                     /locus_tag="ctg32_8"
                     /transl_table=11
                     /translation="METQQLQYKLSAFEGPLDLLLTLISKNKIDIYDISISELLDQYME
                     QINMMQENQMDIASEFLTMASRLVYIKSVMLLPKYEEEAEELKKELSGQLLEYAVCREM
                     AAKLGDIYDFDSFYREASPVEFDLTYNRIHPSEDIAKAYVSAVGRGKRKLPPSKDAFSG
                     IVSHKIVSVNSKIIHLMRRLWHGKRLEYHEIFEVCEGKSDLVATFLATLELVKGKRIRI
                     EGSGENAVVHMIEDKNAMPLPQVDEDENNENEEVQ"
     CDS             6097..6711
                     /locus_tag="ctg32_9"
                     /transl_table=11
                     /translation="MAVENIRGAIEAILFANGASVEFSRIAQALEISEKKVKEHISALI
                     DDYEASGRGITIILLDNSCQMVSKKEFAPQIRTVMDLRRNTPLSQAALEVLAVVAYNQP
                     VTKAFVEQVRGVDCSGVIGSLTTKGLVEEKGRLELPGRPLLYGTTENFLRCFNISSLDE
                     LPPLPESDEDKESEENGEEQEKTENGNEQIDLLADQPVDRQ"
     CDS             6731..7351
                     /locus_tag="ctg32_10"
                     /transl_table=11
                     /translation="LLWLYILLGIVLFIALVMFIPITLRASYKEEFWCAVYIGFVKLQL
                     VPAKPKKEKKKKKAKKQTQKTEQPKKATEKKPSLIKKYGIEWLLNLIKKVAELAVSALQ
                     DFFSHILVKKLSLSISVAGDDAADTAIKYGKYCAVVYPAVGTIVRVVKCKGYGVDINPN
                     FSEKAETEINFDFAARIFAFRLIGLAVKHGIKGIKLLAEVKND"
     CDS             7382..7801
                     /locus_tag="ctg32_11"
                     /transl_table=11
                     /translation="MEHPIGSLMDTTMEKIKEMIDVNTIIGEPITSPDGTLIIPVSKVS
                     YGFAAGGSDLPTKKENKDCFGGGSGAGVTIQPVAFLTVYQGDVRLVSVDREEGTADKLV
                     NMIPDVLKKVKGVFKKDKSESADDFSEITQDDIDG"
     CDS             7853..8977
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_12"
                     /sec_met_domain="Peptidase_S11 (E-value: 7.2e-59, bitscore:
                     189.4, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIISLAECFVMPFVLMGAKTAEDTPPTTSAQAFVLYCPDNNTV
                     ICSKNADEKMKPASTTKIMTSLITLEEAASCNSEVTFKQEMVAEGSSMYLKVGEKVRLS
                     DLASGMMMASGNDAANAAAYTISGSPEKFSQRMNEKAKQIGMTNTNFVTPSGLDDDNHY
                     SSAKDMALLMSYALENDDFANLTAKKSVTVEFLEPKSKKTAYANHNRLLSLYPYCTGGK
                     TGYTTAAGRCLVSSAKKDGVTLVCVTLNDRNDWNDHISLYDYAFEKYRGVDCKDADFCA
                     DIPCVGGDKDSVTVTGEKNNTIVLKREDCDKIKKKIFIDSFLYAPIEKNESVGRIEYTL
                     GGKLLYKCNIVAGEKIKSDKKSVSIFSAIGNLFS"
     CDS             9021..9770
                     /locus_tag="ctg32_13"
                     /transl_table=11
                     /translation="MAKIEPIRLQKFIAQCGIASRRKAEELILGGHVKVNGKTAILGDK
                     VLPTDKVFVRGKRIVVPKGGNYRYIMLNKPRGFITTMNDERGRKCVAQLVENVGERVYP
                     IGRLDKDSEGMLVFTNDGDFANKVMHPKNNVYKIYRVTVRPSIDEDQLVKLETGVELDG
                     RKTAPAYVHVIHKEQGRVVLEMILHEGKNREIRRMCEAVGLEVARLKRTQIGGVKMGML
                     KQGDWRDLTEQEVKKLLANPFLNGKQL"
     CDS             10001..11314
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_14"
                     /sec_met_domain="CT_Vparvula (E-value: 1.3e-76, bitscore:
                     248.5, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIEKINQAKAEIAATSAYKTITAFFDADSFCEIDAFAKSGEGFA
                     EVVAGFGTVEGMPVYAFAQNSDICGGAMSKAQAAKLKKLYGLALKTGAPVVGFYDSVGG
                     RLNQGTELLAGCGDVLNAAASLSGVVPQISVVLGTCLGTNALNAASADIVIMSKDAQLS
                     LSVTGKHSDAAYNAENGIASIVCDDADKAIKAAKELILYLPSNNLTMAPQSFEEAPAED
                     GCGCVVSRTVDGNSIVKLFNDYGKEANVRFARLGGQVVGIVVTKGNELGCKSANKVAKF
                     VRFCDAFSLPVVTFVNCPGFESIKSATKASAAYAEATTVKISVVTGKAIGSGYVALAGT
                     GANADVVYALPDAVISPVNVEAAAFIMAPEVMNVATDKQAEVAQKFADENLSAYNAAQN
                     GYVDGIVEEAQLRQTLISALDMLSGKRVSTLSKKHSTI"
     CDS             11353..11718
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 65.7; E-value:
                     8.2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_15"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.5e-21, bitscore:
                     65.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLRITVNGTAYDVQVEELGGSSAPAAAAPAPAAAPAPAAKPAA
                     PAGAQGSVVVKAPMPGTVVNVVVSAGQAVKAGDDLVFIEAMKMETPVKAPQDGTVATVD
                     VAKGESVDSGKVLVTLN"
     CDS             11749..12819
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_16"
                     /sec_met_domain="HMGL-like (E-value: 6.8e-50, bitscore:
                     160.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 2e-10, bitscore: 31.0,
                     seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKIRVTETALRDAHQSLIATRMTTEEMLPVLDKLDKIGYYSLE
                     CWGGATYDSCLRFLNEDPWDRLRTIREHCPNTKLQMLFRGQNMLGYRHYADDCVEYLVQ
                     RSIANGIDIIRIFDALNDIKNLKTAIKAANKEGGHAQVAISYTTGPVFTDEYYVEYAKR
                     IADAGADSICIKDMAALLTPTRTESLVKAIKAAVPELPLQLHTHYTSGLASMCLLKGVE
                     AGADGIDTAISPLALGTSHAPTESMVAALSGTEFDTGLDLKQFSEIRAYFMTLREKYIK
                     SGLLDPKMLATDANALIYQVPGGMLSNLLSQLKQAGKEDKLDEVLAEVPVFVRIQVILR
                     LLLRHHRLSAHRLYSM"
     CDS             12840..13151
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_17"
                     /sec_met_domain="PYC_OADA (E-value: 1.6e-24, bitscore:
                     77.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCTNEFKGLVAGEYGTTPMPIDPAFQKKIIGDKKIIKGRPADQLK
                     PELDKLRGEIEQWIEQPEDVLSYAQFPKVALDFFEKRRNAKVGINGDKLDKKNMVHPV"
     CDS             13346..14353
                     /locus_tag="ctg32_18"
                     /transl_table=11
                     /translation="MKKLLTALIAFVMCFSVVTTAFAATPDETSDSDLISDIKQAMLDT
                     YYGDEKPEYLNVEILLDDEDEVYFSFSDSFATSANRVYTEAGNYIVSYLENCPVALYKN
                     NRVYMIPDAYNSGIIDDDTLEGLTYCGHMDIVPKSDDSALVIEIKNKVIEECFDGKSPE
                     TLRIDIVGRTSDGGVCFRYSFGGGMDVIVEETIGDYTYSYNHGDDVMLYKNGNVYSIKE
                     AYESGVIDDSILEELSKMNFGLKSNKPNTTVPTEPTTTVATVDEPVTVPDTTSATSATK
                     PVSTSDTATNDTLSNSQSNGGAVQTGQNSVAVILLVAMLAGCAVIFAKRRNHFE"
     CDS             14451..14987
                     /locus_tag="ctg32_19"
                     /transl_table=11
                     /translation="MSKYSYEFKKKVVMDYINGKGGYKSLCKENGIPSQTILRDWITAY
                     KKFGNKGLMRSREKKNYSFEFKMHVVELYLTTEVSYRELALSLGINNPPMIAKWVTDYR
                     AVGPDALRPKRKGRKPKVSKPKKIIPNTGKEKAESEYLKQLEDENLRLRIENAYLKELR
                     RLRLEEEKPPKNRQE"
ORIGIN
        1 gatatataat agggatatca aactaaagga atgaaaaaaa tgtctaaaaa aatcaaaaat
       61 atgctttcaa ttctcttcgt ggctgtactt accgtgtcag cattctgtat tcctgcaagt
      121 gctgccgagg ataaccttac aatcagcatt tcaacagatg aaaaggattc cgtaacagct
      181 aaagtcggcg atacggtaaa gtatgctatt tatatgaccg atacaaaaga agaagtaatc
      241 ggtgctgcaa tgagtttctt ttacaacgat gaatatttga agttgaatgc cgattcaata
      301 aactgtgaaa gctttaaaac tgcgattggt aaccctaaac ttaagaattt ttacaccttt
      361 acatggacag atgttcagaa tcccgtaaag cttaacggtg acaaggctct tgtttctgct
      421 gaattcaagg tactaaaggg aggcaaaacc gatctttcat atttcatctc ggatatgtac
      481 ggcgatgata tgacatatct caaatcgtat aaaatcacct gcaagctttg ggtgaacggt
      541 aaagaggtag aggatagtgc cgttccgata gtaaataatg atacggcaaa ttccgaaaaa
      601 attcagggcg attttgtaaa ctacattgac ggaatgggcg aggaaaactc acctaacaaa
      661 gacgaccata agtcggtagt tgttgagaaa aagtacatct caactcagca gaatagtcag
      721 gttgtagatg ttacaaaggt tgttgagagc tctgcaaacg gttcgggttc aaacacgaca
      781 ttaattatta taattgcaat tgttgttgtt ttgattgccg caggtgcaat tattttcgta
      841 aagaaaaagg acgaaaaaaa gaaaaaatct gcggacaata atgcaatgtc ggacgacgca
      901 gatgcggata aataaaacag ataaatatct tttataggaa aattttttat aatacaagct
      961 aaatacacaa aattgcgatt gcaattttgt gtattttttt gttttaagct ttttgaaaaa
     1021 gattgcaatt ttgaaaattt tgttatataa tgattccata ccgatagaaa tcggaaattt
     1081 ttttggagga gattcaaatg tcaaaaaaac ttatcagtat catagtgtca tgcgctctcg
     1141 ttctttcact tgctcttgta ggtgtaatcg gcgtttccgc agctattgat acaaacggtc
     1201 gttatgtccc aagtgagggc gtagaagaaa cacacagagt ttacttcctt atgcctgagt
     1261 catggaagag tgtaaagttc aatgctaatg atgcaggtgc atactggtgg aacggttcag
     1321 acgcaggcaa ctctcttgac ggtacgtcag taggtgttgc ttggccgggt tataagatgc
     1381 aggttgaaaa tgctgaaaat aacatcttct atcttgacct tcctacagat gttcctaatc
     1441 ttgatttcaa caactacctt aacggcggtc taaggacaga agatgccgca acaggtaaag
     1501 taacttacga gtttagtgag gaacagttta aggctgctaa gcagactgcc gatgtttctt
     1561 gtcagtacta ttcggaaggt gacaatgaat attatgacaa tttgcttgac ggcgaattct
     1621 ggacaaaggc tcaggaagca tttgacggta atgataagac attcctcggt aaatttgctg
     1681 acaacttctt tgaggatcct gactggggta tctcaatgta cctcaccaac atgatttatg
     1741 ttatagaccc tagcaacact tctgtaagcg taacaggtaa ggaaacatat gccggtgagt
     1801 tctacttcta ctatggtctt aacgaagaaa caggcaagta cgagtacggt tcacttccta
     1861 actatgatat ggctaaggaa gcaggtcttg ttcagtcagt agacaagaat gctacacctg
     1921 atcaggctgc aacaacagct ccgtcaagtg acaagaaaga tgacaacaag acagattcta
     1981 caaagaacac agttcctact gcaggtcaga acccaacatc ttctgcaaac gcagtttcaa
     2041 ctgctgacac agcaaagagc acagacaaca gcgcagttca gacaggtgct acaacagcag
     2101 ctgcagttct cgcagttctc ctcgttgcag gcggtgcagt tctttacaca cgcaagagat
     2161 ttgaataatc ttaaataatt atacataatt atttgatgcc ctccgctttg gagggcattt
     2221 ttgcttttat tatagataaa atttgcagtt gtttgtactg cctttgttcg gataagacct
     2281 aataaagata ttttataaaa cagtacagtg atttttggtg attattacaa taggtttcag
     2341 acgccaaaat gccctgtaac acttgatttt ttctgagttt tatactataa tagtcatgct
     2401 gatacaagta tggtgtcgga aaatcataag gaggaaatac aaatgtccaa aaaagttatc
     2461 agtcttttat tggctgttat gctcacagcg gcaatgatag tggttgctgc aataagcgtt
     2521 tctgctgata cggacgatga aggcagttat gtgccttctg agggcactga aacctaccat
     2581 atatatttct gtaagcctga tgactgggaa aacaaatata catctgatgc aggtgtttat
     2641 tgggaaaacg gttcggatac tccttcagcg tggccgggtt attcagctcg caatgctgat
     2701 atcaaaaatg tttactgttc tgatgtaccg accgatgctg ataaagtaat ctggaacaac
     2761 gctcttaaag gtacagacga tccgacaaat cctgaatata aacttgctta tcgaacaacc
     2821 gatattaatt ttaagggtta tgataaaggc gagtctgatt attatcccaa cggtgttgaa
     2881 agctttgaca atatgattta tattatcaat cctgaattta cttccgagaa cgataaggat
     2941 gaattgattt ttgccggtga gtggttctac tactacggta acggtgaata cggcaatgct
     3001 cctaaaaagg cagacctcaa ggccggtgat tattacggca aagacggtgt gttcccgaca
     3061 gagtacaatc caacgggtga ggaaacaaca gccgaatcaa caacagaggt tgtaacagaa
     3121 tcggaaacaa ccgagtctgc aactgatgcc cccgttgcaa cagagggtac aacatcatct
     3181 gctgaatctt cgcttgctct tactgtaaat gcaacatcaa attacttccc aatggcaagt
     3241 gcaaagtata atgcagttac aaatcaggta acggttacat atattatgca gtctccaaag
     3301 aatgtgcttg acacgcagtg gcacatttct tatgaccctt caatcctttc ggttgctgat
     3361 gtgaatactg ctaagtcggt ttgcccgacg atggacggca gaggtgtata tgtaaacttc
     3421 aagaataagt cggaaggcgt tggttatgta aaattcggtg caagtaatct cggtctttat
     3481 gactttagcg aaaagacgct ttttgcaaca gttgtttttg atgttaaaga cgtttcaaag
     3541 gttgcccctg tttctacaac ggttgacctt gttgttgagg tgcttcgtgt ttcggaagta
     3601 aatccggaca cagaaatgac tgacggttca aaagaagtta ttctcgttga taaagaagta
     3661 gttaagaaag ctcctgttgc tgcggcagta aaaaatgatc tttcaactga gcttactcct
     3721 tcaacctatg cagaaccgac aacagccgag ccttcaaccg cagagtcatc tactgaggct
     3781 actaaggcta cagaggaaac gcaggaatca actaaggata caattgctcc tgtaacttca
     3841 caggatgcaa catctgtaac acagcctgta acaaagaaaa tcagctcaac atccgacact
     3901 ccggatacat ctgataacgg cggtaataac aatgcaaatg ctgctgttca gacaggtgaa
     3961 gctcctcttg cagttgtaat tctctctctt ctcatcggct caacttgtgt aatgttcgtt
     4021 cttcgtaaga aagaagaaat cctttaacgg ctgataaaga ctaataatta agagggctga
     4081 ccaaacaaag gtcagccctc tttctgtgct gtgattgtgg tttaaaatcc tgataaaaat
     4141 acaaaaaaac agctccaccg taaatagtgg agctgtttcg taatctgtaa aatcagttag
     4201 ctctggtaac cttacctgaa cgcaaacaac gggtgcaagc atatacacgc tttggtgaac
     4261 cgtcaacaat agccttaaca cgctgtacgt tgggcttcca tgttctgttt gatcttctgt
     4321 gtgagtgaga taccttaata ccgaacttta catccttacc gcagaattca cattttgcca
     4381 tgcgtctgca cctccttaaa gaaaactaat tctatttcta actttgttat aataacagaa
     4441 aatgagagaa aatgcaagtg ttttttgaaa atttcttaac ttgttttttg ctcttgtaat
     4501 ttttgacgat atattatata attaagaata aatatagtta cacgattgtt acctaaaaat
     4561 tcagatttca ggaggctctt atgctctcat tattacttaa cggcatcaga aacggcaacc
     4621 ttgatttcgg ctcggtaatt gccgaaatat tggctgtact cgttattata tttttaattc
     4681 tcccgttcca tgaatgggcg cacgctttta ctgcgtcact tctcggtgat aaggcggtaa
     4741 agggcagagg cagactttcg attaatccgc tcagccacat tgaccctatg ggtgctttgt
     4801 gtatgctttt gttcggattc ggttgggcaa agcctgttcc gattgatccg agaaatttta
     4861 aaaatccaaa ggtcggtatg gcaatcaccg ctattatggg tccgattgca aatatcgttg
     4921 cggcttttgt cggacttctc atttactatc cgattatcct ttttacaggc gcatttccgc
     4981 tttcgacaat cggaggatat gttgttcaat tcttgagctt ctacatttcg tgcaatgtcg
     5041 gacttgctgt gttcaacctt atcccgattc cgcctcttga cggttcaaag gttctcttcg
     5101 tatttttacc cgacaaggct gttgaattct tttacagata tcagatgtac ttttttatcg
     5161 gtctttttgt tctcttgtat gtgggaattc tcaacactcc gattaactgg ctcagcaatc
     5221 agattcttga cttcatcagc tggcttgcaa gcctgccgta tatgccgttt gtcggttgat
     5281 ttcaaaatta ttcgcaacat caaatcataa ctgaaactta tttatggaaa cacaacaact
     5341 tcaatataag ctgtcggcat ttgaaggccc tcttgacctt ttgctgacgc tgatttctaa
     5401 aaacaaaata gatatttacg acatcagcat ttccgaattg ctcgaccagt acatggagca
     5461 gattaatatg atgcaggaaa atcagatgga tatcgcatcg gaatttctga caatggcgtc
     5521 aaggcttgtt tatatcaagt ctgtaatgct cctgccaaaa tatgaggaag aggctgaaga
     5581 actcaagaaa gaactttcgg gacagcttct tgaatatgcc gtttgccgtg aaatggcggc
     5641 aaagctgggc gatatttatg actttgacag cttttacaga gaggcttctc ccgttgaatt
     5701 tgacctgaca tataaccgaa ttcatccgag tgaggatatc gcaaaggcat atgtcagcgc
     5761 agtcggacgg ggcaagcgta agcttccgcc gtcaaaagac gcattttcgg gtattgtgtc
     5821 gcataaaatc gtgtcggtaa acagtaagat tatccatctt atgagaaggc tctggcacgg
     5881 caaaaggctt gaatatcacg aaatttttga ggtgtgcgag ggcaaaagcg accttgtggc
     5941 aacatttctt gcaacgctgg agctggtaaa gggcaagcgt atcagaattg agggcagcgg
     6001 tgaaaatgcc gttgttcata tgattgagga taaaaacgca atgcctttgc cacaggttga
     6061 cgaggacgaa aacaatgaaa atgaggaggt gcagtaatgg ctgttgaaaa tattcgtggt
     6121 gcgattgagg cgattttgtt cgcaaacggt gcgtcggttg aattttcccg aatagcgcag
     6181 gcacttgaaa tttccgaaaa aaaggttaaa gagcatattt ctgcactgat tgatgattat
     6241 gaggcgtcag gacggggcat aactataata ttgcttgaca attcctgtca gatggtttca
     6301 aaaaaggaat ttgctccgca gattcgtacc gttatggatt tgagaagaaa cactccgctt
     6361 tcacaggcgg ctcttgaggt tcttgcagtt gttgcgtaca atcagcctgt tacaaaggct
     6421 tttgtcgagc aggtgcgtgg cgttgactgc agtggtgtaa tcggcagttt gacaacaaag
     6481 ggacttgttg aagaaaaggg cagacttgag ctacccggca gaccgttgct ttacggcaca
     6541 accgaaaact ttttgcgttg ctttaacatt tcaagtcttg acgaacttcc tccgctcccc
     6601 gagagtgatg aggacaagga gtccgaagaa aacggtgaag aacaggaaaa gactgaaaac
     6661 ggcaatgagc agattgattt gcttgccgat cagcctgttg acaggcagta aaatttaggg
     6721 ggaattccct ttgctttggc tatatatcct actcggaatt gtgctgttta ttgcgcttgt
     6781 gatgtttatt ccgattactt tgcgtgcatc atataaagag gagttttggt gcgccgtgta
     6841 tatcggattt gtaaagcttc agcttgtgcc ggcaaaaccc aaaaaggaaa agaagaagaa
     6901 aaaagcaaaa aaacaaactc agaaaaccga acaacctaaa aaagcaacag aaaaaaagcc
     6961 gagtcttata aaaaaatacg gtattgagtg gcttttgaac ctgataaaaa aagttgcaga
     7021 gcttgcagta tctgcattgc aggatttttt cagccacata ctggttaaaa aattgtcgct
     7081 gagtatcagc gttgcaggtg acgatgcggc tgacacggct ataaaatacg gcaaatactg
     7141 tgccgttgtt tatccggcag taggcacaat tgtccgtgtt gtaaaatgca aaggctacgg
     7201 agttgacata aatccgaatt tttcggaaaa agcagaaaca gaaattaact ttgactttgc
     7261 cgcaagaatt ttcgcattcc gacttatcgg tcttgccgtt aagcacggaa tcaagggaat
     7321 taaacttctt gcagaagtta aaaatgattg atataaatat tgttgaaaaa ggagaatggc
     7381 tatggaacat cctatcggca gtttaatgga taccacaatg gaaaaaatca aggaaatgat
     7441 tgatgtcaat actattatcg gcgagcctat aacttcgcct gacggcacac tcatcattcc
     7501 tgtttcaaag gtaagctacg gctttgcggc aggcggttcg gatttgccta ccaaaaagga
     7561 aaacaaagac tgctttggcg gcggcagcgg tgcaggtgtg acaattcagc ctgttgcatt
     7621 tcttaccgtt tatcagggcg atgtaaggct tgtttccgtt gacagggaag aaggtacagc
     7681 cgacaagctc gttaatatga ttcccgatgt tcttaaaaaa gtaaagggag ttttcaaaaa
     7741 ggataagagc gaatccgcag acgatttttc cgaaatcaca caggacgata ttgacggctg
     7801 attcgtaata ttgcaacacc cctcggcata gatttatgca gggggtgtcc ttatgaaaaa
     7861 aataatctcg cttgcggagt gttttgttat gccgtttgtg cttatgggcg caaaaactgc
     7921 ggaggatact cctcccacaa cttctgcaca ggcatttgtc ctgtactgtc ccgataacaa
     7981 cacggttatc tgttccaaaa atgcagatga aaaaatgaag cctgcgagca ctacaaaaat
     8041 tatgacatct ctcataacgc ttgaggaggc ggcatcctgt aacagcgaag taaccttcaa
     8101 acaggaaatg gttgccgagg gcagttcgat gtatcttaaa gtcggtgaaa aagtccgact
     8161 ttcggacctt gcgtcaggaa tgatgatggc gtcgggtaat gatgcggcga atgcggcggc
     8221 atatacgatt tcgggcagtc ccgaaaagtt ttcacaacga atgaatgaaa aggcaaagca
     8281 aatcggtatg acgaatacca attttgtaac gccgagcgga cttgacgatg acaaccatta
     8341 ctcaagtgca aaggatatgg ctctgcttat gtcatatgca cttgaaaatg acgattttgc
     8401 aaatcttacg gctaagaaga gcgtgaccgt tgaattcctt gaaccgaaat caaagaaaac
     8461 cgcatatgca aatcataaca ggcttttgtc gctttatccc tactgtacag gcggaaaaac
     8521 aggctataca acggcggcag ggcggtgcct tgtttcctct gcaaaaaaag acggtgtaac
     8581 gcttgtgtgc gtcactctga atgaccgcaa cgattggaat gaccatattt ctctttatga
     8641 ttacgctttt gaaaagtaca ggggagttga ctgcaaagac gctgactttt gtgccgatat
     8701 tccgtgcgtg ggcggtgata aggacagcgt aacggttaca ggggagaaga acaacacaat
     8761 cgttttaaag cgtgaggact gcgataaaat caagaaaaaa atcttcatag acagcttttt
     8821 gtatgctccg attgaaaaga acgaatcggt cggcagaatt gaatacacac tcggcggaaa
     8881 gctgctttat aaatgcaaca ttgttgcagg cgaaaagatt aaatcggata aaaagagtgt
     8941 gtcaatattt tcggcaatag gaaatctgtt ttcgtgacag cttaaatata cagaaaattt
     9001 taataaaaag gaatttacat atggctaaaa ttgaacctat aagacttcag aaattcatag
     9061 cgcaatgcgg tattgcgtca aggcgaaagg ccgaggagct tattctcggc ggtcatgtca
     9121 aggtgaacgg caaaaccgca attctcggcg ataaggttct tcctacagac aaggtgtttg
     9181 taagaggcaa gaggattgtt gtgccgaagg gcggtaatta ccgatatatt atgctcaaca
     9241 agccccgtgg attcattacc acaatgaatg atgagcgtgg cagaaagtgt gttgcacagc
     9301 ttgttgagaa tgtcggcgag cgagtttatc cgataggcag acttgacaaa gacagcgagg
     9361 gtatgcttgt ttttacaaat gacggtgact ttgcaaacaa ggttatgcac ccgaaaaaca
     9421 atgtttacaa gatttacaga gtaaccgttc gaccgtcaat tgacgaggat cagcttgtaa
     9481 agcttgaaac aggcgttgag cttgacggca ggaaaaccgc tcctgcatat gtccatgtaa
     9541 ttcacaagga gcagggcaga gtagttcttg aaatgattct tcacgagggt aagaaccgtg
     9601 aaatcagaag aatgtgcgag gctgtcgggc ttgaggttgc aagactcaaa cgcacccaga
     9661 tcggcggagt aaaaatgggt atgctcaaac agggcgactg gagagatttg accgaacaag
     9721 aggttaaaaa actgcttgca aacccgtttt taaacggcaa acagctttaa ttttccgttt
     9781 ttgaaaaata cttccgaaac ggtcaatcaa actatttgtt aatttgacaa taaatttacg
     9841 gttttggtgt aataactatt aaatgtgttc aaaattgaaa tagtacagcg tgtttttctt
     9901 gtacttttga agattataga gtataatgta ttgtgtagaa aattagtatg cacgctcagt
     9961 tttcgtgcat attcaataca tggtattgga ggattttaag atgagtattg aaaagatcaa
    10021 tcaggcaaag gctgaaattg ccgcaacttc cgcttataag acgattacgg cgttttttga
    10081 tgcagacagc ttttgtgaaa ttgatgcctt tgcaaaatcc ggtgaaggtt ttgccgaggt
    10141 tgttgcaggc tttggaacag tagaaggtat gcctgtttat gcgtttgcac agaacagcga
    10201 catttgcggc ggtgctatga gtaaggcaca ggctgccaag cttaaaaagc tgtatggtct
    10261 tgcactcaag acaggtgctc ctgttgtagg tttctatgac agcgttggcg gcagacttaa
    10321 tcagggtaca gagcttctcg caggttgcgg tgatgttctc aatgcggctg cgtcactttc
    10381 cggtgttgta ccgcagatct cggttgttct cggcacttgc ctcggaacaa acgctcttaa
    10441 cgccgcaagc gcagacatcg ttatcatgag caaagacgca cagctttcac tttcggtaac
    10501 aggcaagcat tccgatgccg cttacaatgc tgaaaacggt attgcctcaa tcgtttgtga
    10561 cgatgcagac aaggcaatca aggctgcaaa ggaacttatc ctttatcttc cgtcaaataa
    10621 cctcacaatg gctcctcagt catttgaaga agctccggca gaagacggtt gcggttgtgt
    10681 agtcagcaga acagttgacg gcaacagcat tgtaaagctc ttcaatgatt acggcaagga
    10741 agcaaatgtt cgttttgcaa gactcggcgg tcaggttgta ggtattgttg ttacaaaggg
    10801 caatgagctt ggttgcaagt ctgcaaacaa ggtagcaaag tttgttcgtt tctgcgacgc
    10861 tttctcgctc cctgttgtaa cattcgtaaa ctgcccgggc tttgagtcaa tcaagtcggc
    10921 aacaaaggca tcagccgctt atgctgaggc aacaacagtt aagatttctg ttgttacagg
    10981 caaggcaatc ggttcaggct atgttgctct tgcaggcaca ggcgctaatg cagatgttgt
    11041 ttacgcactt cccgatgcag ttatttcacc tgttaatgtt gaggctgccg cattcattat
    11101 ggctcccgaa gttatgaatg ttgccacaga taagcaggct gaggttgctc agaagtttgc
    11161 tgacgagaat ctttctgctt acaatgccgc tcagaacggc tatgttgacg gtattgttga
    11221 agaagctcag ctccgtcaga ctcttatttc tgctcttgat atgctctcgg gcaagcgtgt
    11281 ttcaacactt tcaaagaagc attcaactat ctgataaatg attacttgtt aaaataaaag
    11341 gggatactaa aaatgaagaa tttaagaatt acagttaacg gcacagcata tgatgttcag
    11401 gttgaagaac tcggtggctc ttcagctccc gcagcagccg ctcctgctcc ggcagccgct
    11461 cccgctcctg cagcaaagcc ggcagctccc gcaggcgctc agggttctgt tgttgtaaag
    11521 gctcctatgc ccggtacagt tgttaatgtt gttgtttcgg caggacaggc tgttaaggcc
    11581 ggagatgacc tcgtattcat cgaggctatg aagatggaaa ctcccgttaa ggctccgcag
    11641 gacggcacag ttgcaacagt tgatgttgca aagggtgagt cagttgactc aggtaaggtt
    11701 ctcgtaacac ttaactaatc aataattcgg agaaagggat gctgtaaaat ggcaaaaaaa
    11761 atcagagtta ccgaaactgc cctgcgtgac gctcatcagt cactcattgc aacaagaatg
    11821 acaacagagg aaatgctccc tgttcttgac aaactcgata aaatcggtta ttactcactc
    11881 gaatgctggg gcggtgcaac atatgactca tgcctcagat tcttaaacga agatccgtgg
    11941 gacagactcc gtacaatcag agagcattgc cccaacacaa agctccagat gcttttcaga
    12001 ggacagaata tgctcggtta tcgtcactat gccgatgact gcgttgagta ccttgttcag
    12061 cgttcaatcg caaacggtat tgacattatc cgtatttttg atgctcttaa cgacatcaag
    12121 aatcttaaaa cagctatcaa ggccgctaac aaagaaggcg gtcatgcaca ggttgctatc
    12181 agctacacaa caggtcctgt attcacagat gaatactatg ttgagtatgc taagagaatt
    12241 gcagacgcag gtgcagattc aatctgtatc aaggatatgg ctgctcttct tactccgaca
    12301 agaaccgaaa gccttgtaaa ggctatcaaa gccgctgttc cggagcttcc gcttcagctc
    12361 cacacccact acacatcagg tcttgcatca atgtgtcttt taaagggtgt tgaggcaggt
    12421 gctgacggca ttgacacagc aatcagccca ctcgctctcg gtacatcaca cgcacctaca
    12481 gagtcaatgg ttgccgctct ttcaggcaca gagttcgaca caggtcttga ccttaaacag
    12541 ttctctgaaa tccgtgctta ctttatgact ctccgtgaga agtacatcaa gtctggactt
    12601 cttgatccta agatgctcgc aacagacgct aacgctctta tctatcaggt tcccggcggt
    12661 atgctttcca accttctttc acagctcaag caggccggta aagaagacaa gcttgacgaa
    12721 gttcttgcag aagtacccgt gttcgtaagg attcaggtta tcctccgctt gttactccga
    12781 catcacagat tgtcggcaca caggctgtat tcaatgtaat cacaggcaag cgctactcaa
    12841 tgtgcacaaa cgagttcaag ggacttgttg ccggtgagta cggtacaact ccaatgccga
    12901 ttgatcctgc gtttcagaag aagattatcg gtgacaagaa gattatcaaa ggtcgtcctg
    12961 cagatcagct taagcctgag cttgataagc tccgtggcga gattgagcag tggattgaac
    13021 agcctgagga tgttctttct tatgcacagt tcccgaaggt tgccctcgac ttctttgaaa
    13081 agagaagaaa tgccaaggtt ggcatcaacg gcgacaagct tgacaagaaa aatatggttc
    13141 acccagtttg atttgacaac aaaaattaac atttatgcca ctttcgctat gaaagtggca
    13201 ttttcatttg agcagaatta ttttatgtga atttttagca actatattgc attacatata
    13261 ttttagcagt ataatgaagt aaattgaata tctgttgcgt ataccattat tacagataga
    13321 ataaataaaa ggtgaggaaa taagaatgaa aaaattatta actgcattga tagcatttgt
    13381 aatgtgcttt tcggttgtaa caacagcttt tgcggctaca cctgatgaaa cttctgattc
    13441 agacttgatt tcagatatta aacaggctat gttagataca tattatggtg atgaaaagcc
    13501 tgaatatctg aatgtcgaaa ttcttttgga cgatgaagac gaggtatatt tcagtttttc
    13561 tgacagcttt gctacttctg caaacagagt ttacaccgag gcaggcaatt acatagtttc
    13621 ttatctcgaa aattgtcctg tggcactgta caaaaacaac agggtttata tgatccccga
    13681 tgcttataat tcgggcatta ttgatgacga tacacttgag ggcttgacct attgcggaca
    13741 tatggatata gttccgaaaa gcgatgattc agcacttgtt atcgaaataa aaaacaaagt
    13801 tattgaagag tgttttgacg gcaaatcacc tgaaactttg agaattgata ttgttggcag
    13861 aacaagtgac ggcggagtgt gttttagata tagttttggc ggtggtatgg atgtaattgt
    13921 tgaagaaaca attggtgact atacttatag ttacaaccat ggcgatgatg ttatgcttta
    13981 taaaaatggc aatgtttact caattaaaga ggcttacgaa agcggagtta ttgacgatag
    14041 tattcttgaa gaattgtcaa aaatgaattt tggtttgaaa tctaataaac cgaatacaac
    14101 tgttcctact gagcctacaa ctacggttgc aacagttgac gaacctgtaa cagtacccga
    14161 tacaacttct gcaacttcgg caactaagcc tgtttcaaca agcgacacag ctacaaatga
    14221 cacactgagc aattcacaga gcaacggcgg tgcagttcaa acaggacaga acagcgttgc
    14281 tgtaattctt cttgttgcaa tgcttgcagg ttgtgcagta atttttgcaa aacgcagaaa
    14341 tcattttgag taatttacaa attaaataat ccctataaaa gccgttctcg ttatgacccg
    14401 acccccaaaa gttagaccta aaaaatctaa ctttggaggt cggtattttt atgtcaaaat
    14461 acagttatga attcaagaag aaggtagtaa tggactacat aaatggaaaa ggaggatata
    14521 aaagtttatg taaagaaaat gggataccga gtcaaacaat attacgagat tggatcacag
    14581 catacaaaaa atttggaaac aaaggattaa tgcgatcaag agaaaagaaa aattactctt
    14641 ttgaatttaa gatgcatgtg gtagaattat acttaacaac ggaagtatcg tatcgagaac
    14701 ttgcattgag tttaggtatc aataatccac caatgatagc aaaatgggta accgattacc
    14761 gtgcagttgg acctgatgcg ttacgaccaa agagaaaagg acggaaaccc aaagtgtcta
    14821 aaccaaaaaa gataatacct aacacaggaa aagaaaaagc tgaatcagaa tatctgaaac
    14881 agcttgaaga tgagaattta agattaagga ttgaaaatgc gtatttaaaa gagctgagga
    14941 gattgcgttt ggaggaagaa aaacctccga aaaacaggca agaataatac acagtctccg
    15001 aggagaattc aggctaaaag atattcttgc cgtaacaggt tttccaaagt caacatatat
    15061 gtat
//
