LOCUS       c00071_gnlPro..        15874 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OICKCHHF_71.
ACCESSION   c00071_gnlPro..
VERSION     c00071_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 03:12:38
            Original ID  :: gnl|Prokka|OICKCHHF_71
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4058
            Orig. end    :: 19932
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15874
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[14058:18702]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14644
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15874
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15874
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(767..1378)
                     /locus_tag="ctg71_5"
                     /transl_table=11
                     /translation="MQILKDNIRSRILDVAKQQFELKGYSKTSMREIAVDVGVGVGNIY
                     NYFKSKDELFHEVVRPVLYALEMLLQEHHGIQGEDIMMMRSEEYLETCINEYISLYDTH
                     HRLMKILLFRAQGSSLERFRENYTDRSTELVKVWFTVMQRKYPMINIAIPDFIIHLHTV
                     WMFTMFEELLRHSIAKQEMKAILHNYILFEIQGWRAIIRI"
     CDS             complement(1477..1992)
                     /locus_tag="ctg71_6"
                     /transl_table=11
                     /translation="MKNCIKTVCFLFWTCVMFIACIDDDVEEGTVDLQTGENIPVFSVV
                     MDDGQIITSETLKGEVSLIVFFHTGCPDCRKELPVLQKIYTDYGQRIRMVCISREESSA
                     EIVRYWDENHLTLPYSAQENRTVYYQFAKSGIPRVYVIDKELVIRSVFTDNPLASYEDL
                     AEAIETCL"
     CDS             2058..3233
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 92.5; E-value: 8.1e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg71_7"
                     /sec_met_domain="MFS_1 (E-value: 3e-29, bitscore: 92.5,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQELKENQGLPASLLWTLAIIAGISVANLYYNQPLLNRISRDLQ
                     TSEFTANLIAMITQIGYAIGLLFIIPLGDLFKRKTIILINFTVLVVSLLTIALTPYIHL
                     ILFASLLTGICSVMPQIFIPIAAQFSTPKTKGRNVGMIVSGLLTGILASRVVSGIVGEY
                     LGWRFIFFVAAGMMVICLIIIMRVLPDMPCNFKGKYSDLMKSLFSLVIEYPQLRISSLR
                     AGIAFGSFLALWTSLAFKMGQAPFFAGNNIVGLLGLCGIAGALTASYIGKYVHVLGVKR
                     LNYIGCGLIFVAWFSLYFGQDSYVGIITGIFIIDIGMQCIQLSNQTTIFALNPKAANRI
                     NTIFMTTYFIGGSVGTFLAGTFWHWFGWQGVVGTGIALTACSFMINIFAKR"
     CDS             complement(3235..3624)
                     /locus_tag="ctg71_8"
                     /transl_table=11
                     /translation="MEIDLTTPALLFSAISLIMLAYTNRFLSYAQLVRTLKDQYRENHS
                     AVTAAQISNLRKRLYLTRAMQVTGIGSLLLCVVSMFLMYIQLYLISVYIFGLALVLLII
                     SLGISVREIYISVKALELHLSDMDS"
     CDS             3743..4912
                     /locus_tag="ctg71_9"
                     /transl_table=11
                     /translation="MQTIKLYIKDWLAIHPYIQQQTTDRYFVDLANRLYSTCTIREIPE
                     SIKKKLCLYTAAYFEDVISGLGLWQAFIKKHLELYDTSLPFYTIRPDYIKDEINEEDIR
                     FIIWNTLEKAPYKHLYINPMDRNIEETAHLFFRILDEEYETAPANATLQEFFMDFKGKE
                     DANHKLRWLFGHTYLTEPSVQEYIAQVTETDKFIIPCGPLALFLHEWIDLLTNGETECW
                     EEIEGLYPAIPEISDEMKERNHHTYQLFTQGTNGARIVYLKSYKELHSFLTQVLQWPDD
                     SNHTLPQMKEHKDFIMMVNSEKGILLAKDICKYISDPLNPMYDAATAAQEAFSLLTIPT
                     KCPPDLMEYLINNHYIPDAQFPEFGEKELVQKNADFIARHSLLYYYRGD"
     CDS             complement(4909..5916)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg71_10"
                     /sec_met_domain="Hacid_dh (E-value: 5.6e-32, bitscore:
                     100.8, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="Hacid_dh_C (E-value: 6.5e-58, bitscore:
                     185.6, seeds: 144, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAYKIAFYDTKPYDEHSFTEANEKFGFDIRYYKGHLNMNNVVLTK
                     GVDVVCIFVNDTADAEVIRAMADNGVKLLALRCAGYNNVDLAATAGKMKVVRVPAYSPY
                     AVAEFTVALMLSLNRKIPRATMRTRDGNFSLHGLMGFDMHGKTAGIIGTGKIAKILIQI
                     LRGFGMNVLAYDLYPDYNFAREHQVVYCTLDELYHSSDIISLHCPLTEQTKYLINDYSI
                     SKMKDGVMIINTGRGQLIHTNALIEGLKTKKVGYAGLDVYEEEEPYFYEDKSDKIIDDD
                     TLARLLSFNNVIVTSHQAFFTKEAMTNIAHTTLQNVKDFVEGRPLVNEVAVGRV"
     CDS             complement(5982..6563)
                     /locus_tag="ctg71_11"
                     /transl_table=11
                     /translation="MLENLEKYKIILASNSPRRKELLSGLGIKYEVKTLPGIEETYPDT
                     LKAEEIPLYIACEKAAAYRNIMHPDELIITADTIVWLDGVVMGKPHNEDDARQMLWKLS
                     GKTHQVITGVCLTTARTQRSFSAVTEVTFAELSDEEIDYYIRVYKPMDKAGSYGIQEWI
                     GFIGVCGISGSYFNVMGLPVQCLYTELKKL"
     CDS             complement(6581..7099)
                     /locus_tag="ctg71_12"
                     /transl_table=11
                     /translation="MINYDLKKIKALVFDVDGVLSAETIYLHPNGEPMRTVNIKDGYAL
                     QLAVKCGLHVAIITGGNTEAVRKRYEGLGIKDVYLAAAVKTREYAHLKEKYGLQDEEIL
                     YMGDDIPDYEVMRLCGLPCCPADAAPEIKETAVYISHRNGGYGCGRDVVEQVLKAQGKW
                     MAHERAFGW"
     CDS             complement(7105..7911)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg71_13"
                     /sec_met_domain="F420_oxidored (E-value: 3e-10, bitscore:
                     31.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVLIGAGNVATHLGIALQKAGCLILQVYSRTEESASALADRLL
                     VDYTIVPDEIRRDADLYIVALKDAVLRQLAPVLVKGREQALFVHTAGSMPMDLWKGLVK
                     RYGVLYPMQTFSKQREVDFNTVPFFIEASAPAEVGVLRMVAVRLSPKVYEVTSGQRRHL
                     HLAAVFACNFANHMYALSSHILEKQGISFEVMLPLIDETAGKVHELSPTQAQTGPAVRY
                     DENVISKHLEMLADEESLQELYEKISKSIHDLPLSVIQTNKEGKNS"
     CDS             complement(7911..8237)
                     /locus_tag="ctg71_14"
                     /transl_table=11
                     /translation="VAAVNHKDTYKASAVFLIVMGMLYLIDKFIGFASHGLPWVMQKDN
                     LLLYAAVIFLWFKADKSVGIVLAGIWLILNISLVIALLGQMSAYLLPAALLLLGVILYL
                     VSTR"
     CDS             complement(8240..8776)
                     /locus_tag="ctg71_15"
                     /transl_table=11
                     /translation="MEQFSDLIKNRRSMRKFTDQELTQEEVVALLKAALMAPSSKRSNC
                     WQFLVVDDKDMLEKLSHCKEMGAAFLADAAMAVVVMADPLASDVWIEDAAIASIMIQLQ
                     AEDLGLGSCWIQVRERFTATGMPSGEYVHTLLDIPLQLQVVSIIAVGHKGMERKPFNED
                     HLQWEKIHINKFGGK"
     CDS             8822..9844
                     /locus_tag="ctg71_16"
                     /transl_table=11
                     /translation="MWIDKQKTINLQLEMPVRLSTYRKGNAIPPLPGTNIFHSTELFHV
                     FEMTRGYEPLLIVAYIGNRPVGKLLAVIRKSMRLFPPAIIKRCEIYGTGEYFDEEQNKE
                     DLFGEMLEHLTNEVLCKSFLIEFRNLENPLFGYKAFRKNNYFAINWLRVRNSLHSKVPY
                     ERLSMSRKRQINKALRNGAIMEVADNEKDIQDFSRMLKKAYSSQVRKHFPDIGFFRLLA
                     WQNPEKELAKVFLVKYKGKIIGGSICLFSKESAYLWFSGGMRKTYAFLYPGILAVWAPI
                     TYAHEKGYAHLEFMDAGLPFKKHGYRDFILRFGGKQSSTRRWFRFSWKWLNKLLCKFYI
                     "
     CDS             10001..10414
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_17"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.3e-25, bitscore:
                     80.5, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVKTA
                     FLKVGDVKIELLEPTSPESTIAKFIEKNNGNGGMHHLAFAVEDGVANALAEAETTGIRL
                     IDKAPRKGAEGLQIAFLHPKSTLGVLTELCEKP"
     CDS             10517..12070
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_18"
                     /sec_met_domain="CT_Btheta (E-value: 9.7e-292, bitscore:
                     958.2, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRATARMGGGDKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKVMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLAMIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPN
                     KPYDMYEVISAIVDNGEFLEVQPHYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             12098..13027
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_19"
                     /sec_met_domain="OAD_gamma (E-value: 2.6e-15, bitscore:
                     47.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLNIGIFLSLLLMVGLCSCGEQKSNTKLVLNEVLIENESNFQD
                     DYGVHSAWIEIFNRSFGSADLAGCLLKVSSQPGDTATYFIPKGDVLTLIKPRQHALFWA
                     DGEPNRGTFHTNFTLNAATNNWIGLYDSGKKLLDQIIVPAGTLQANQSYARVSDAANEW
                     EVKGSSADKYVTPSTNNKTINSNAKMEKFEEHDSVGIGMSISAMSVVFVGLLLLFIAFK
                     VIGRISVNLSKRNAMKVKGITDKQEAKEKKLGEAPGEVFAAIAMAMHEMQSDVHDVEET
                     VLTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             13051..13482
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.7; E-value:
                     1.8e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_20"
                     /sec_met_domain="Biotin_lipoyl (E-value: 6.6e-21, bitscore:
                     64.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNIYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAV
                     VKPVVRPASTSPAPAPTTVVKPAATSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVSKGESVLEGTDLVIIE"
     CDS             13484..14644
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_21"
                     /sec_met_domain="OAD_beta (E-value: 3.4e-153, bitscore:
                     500.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFINFLGNNLADFWTYTGFANATVGHIVMILIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALAMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGLTVGAS
                     TQASEFLTIDSILIFALGALSFIIATASGVIFVKIFNLVLGKDNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             14819..15067
                     /locus_tag="ctg71_22"
                     /transl_table=11
                     /translation="MEKKTVKYHIPQHGIYMYARTNSGKTELIVLNSTNAEQVVANNHY
                     RIMTNDSKSGKELISGKKIDLTKNMTVGARQSLIIEL"
     CDS             complement(15159..15872)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg71_23"
                     /sec_met_domain="adh_short (E-value: 2.6e-48, bitscore:
                     154.7, seeds: 44, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="AGCARKFASQGASLILNARNVNKLSALKEELEKQYGTEIYLLPFD
                     VRDRKAATSALESLPKEWQSIDILVNNAGLVIGTDKEQEGSLDEWDIVIDTNVKALLAM
                     TRLIVPGMVERKRGHIINIGSIAGDAAYPGGSVYCATKAAVKALSDGLRIDLVDTPLRV
                     TNIKPGLVETNFSVIRFRGDKEKADNVYKGIRPLTGDDIAETVYFAASVPEYMQIAEML
                     VMPTYQATGTIVSRK"
ORIGIN
        1 gaagtactca tcctttcctg tgcatcgtaa tagacacgca taaactcctt cgctttcttt
       61 cccataaaat tggagaattg taggaaaagg cttaatacga caactgtcaa acacgccact
      121 gtcaaccata catttaatga gaagaaaatg acaaacatca ctgccaccgt agctatcaca
      181 tttaccaaat cggggatagt atgtgcaatg aatccctcta tcttctcgat gttctgatcc
      241 atcgttttct tgatggaccc gatggaagtg ttgttcagat agcccaacgg aagtttaccg
      301 atatgttcgg ataaacggac acgcaaccca tacaagattc ggaatgcggc tacatgagag
      361 gacataaggg cagcgtacag caaaaccaat ccgccgacaa gtccacccag tgcgatccat
      421 ccccaacgta tcatttcagt tccatttgcc aaaacaggat tgctgccatg caacaacaac
      481 tctttcagca cctcatagac agcccaatag ggtacaagca tacacatggc actacctacc
      541 gacagcaaac ctgccagcag aagcaaccct ttcttctgtc ccgcaatctc taacaaacgg
      601 ggcaatcctt ctttcttctt tttcatataa ttgtactata tcaaacggat tattagtgaa
      661 cggtattcaa atttgttcat aaaaaaagga ggaaacctcc gtaaagactt cctcctttcc
      721 tgctgcctta ctgtagcaac cagtctgtat atacaaattt tacctgtcat attcgaataa
      781 tggccctcca accttggatc tcaaatagaa tataattgtg taaaatagct ttcatttcct
      841 gtttcgctat tgaatgcctc aaaagctcct caaacatagt aaacatccat acagtatgca
      901 aatggattat aaaatcggga atagctatat ttatcatcgg gtattttctc tgcatcaccg
      961 taaaccagac tttgactaat tcggttgaac ggtctgtata attctcccga aaacgttcca
     1021 atgaagaacc ttgcgcacga aataacagta ttttcatcaa tctgtggtgg gtgtcataca
     1081 aggaaatata ttcgtttata caggtttcca agtattcttc cgacctcatc atcataatat
     1141 cctcgccctg tattccatga tgttcctgca acagcatttc caacgcatac aaaaccggac
     1201 gaacaacttc atgaaacagc tcatccttac ttttaaagta gttgtaaata tttcccaccc
     1261 caacacctac atccacagct atctcacgca tggaagtctt ggaataacct ttcaactcaa
     1321 attgttgttt ggctacatcc aaaatacggc tacgtatgtt atcctttaat atttgcatgt
     1381 atagtcagct gtgattctgt ttttatgatg gcaaaggtaa tgagcttatc attatctgac
     1441 aatacctatt tttagggatt ttaccctctc taaaaactac aaacaggttt ctatagcctc
     1501 agccaaatct tcataacttg ccaacgggtt atccgtgaaa acactacgga taaccaactc
     1561 tttatctatg acataaacac gaggtatccc cgatttagca aactgatagt ataccgtgcg
     1621 gttttcttgg gccgaatagg gcaaagtcaa atgattttcg tcccaataac ggacaatctc
     1681 tgccgaactc tcttccctgc taatacaaac catccggatt ctttgaccgt aatccgtata
     1741 tattttttgc agcacaggaa gttctttccg gcagtccgga caacccgtat gaaaaaacac
     1801 aatcaaggaa acctctcctt tcagggtttc ggaagttatt atttgtccat catccattac
     1861 cacagaaaaa acaggaatgt tctctcctgt ttgtaaatca acagtacctt cctccacatc
     1921 atcatcaata cacgctataa acattacaca ggtccaaaac agaaaacaga ccgtttttat
     1981 acaattcttc attttcattt ctatttttct tctttacaaa gataacatga ttttcatgaa
     2041 attactactt ttgcagcatg aaacaagaat taaaagaaaa ccaaggacta cctgcctcct
     2101 tactttggac gctagcaatt attgcgggaa tctccgttgc caatttatat tataaccaac
     2161 ctttattaaa tcgcatcagc cgtgatctcc aaacatccga attcaccgcc aacctgatag
     2221 caatgattac ccaaataggt tatgccatcg gattgctgtt cattattcct ttgggagatt
     2281 tatttaaaag gaaaaccatt attctaatca atttcacagt cctagtcgtt tcattactaa
     2341 ccatcgcact gactccttat atccatctca ttttatttgc ctctctgctg accggcattt
     2401 gttcggtgat gccacaaatc tttatcccca tagctgcaca attctccacc cccaaaacca
     2461 aaggaagaaa tgtaggcatg attgtatcag ggttactgac tggtattttg gcttcgcgcg
     2521 tagtcagcgg aattgtcggc gaatatttgg gatggcggtt tattttcttt gtagcggcgg
     2581 gaatgatggt gatatgtctc atcattatca tgcgtgtact acccgatatg ccatgtaatt
     2641 ttaaagggaa atatagtgat ctgatgaaat ccttgttttc attagtgata gaataccccc
     2701 agttacgtat ttcttcctta cgtgccggaa ttgctttcgg ttcattccta gctctgtgga
     2761 cttcgctggc attcaaaatg ggacaagctc ctttctttgc aggaaacaat attgtagggt
     2821 tattaggatt gtgcggcata gcaggagctc tcaccgcctc gtatatagga aaatatgtac
     2881 atgttttggg agtcaaacga ctgaattaca taggttgtgg cttgattttt gtggcgtggt
     2941 tctcacttta tttcggtcag gactcttacg tgggtatcat caccggaatt tttattatag
     3001 atataggtat gcaatgtatc caattgagta atcagactac gattttcgcc ctcaacccga
     3061 aagcagccaa ccgtattaat accattttta tgacaactta ttttataggt ggttccgtag
     3121 gtacattcct tgccggaaca ttctggcatt ggtttggatg gcaaggagta gtaggaacag
     3181 ggatcgcatt aacagcctgt tcctttatga taaatatctt tgcaaaaaga taaatcaaga
     3241 atccatatca ctcagatgca gttccagcgc cttgacggaa atataaatct cgcggacaga
     3301 aatgcctaaa gaaataatga gcagcaccag tgccagtcca aaaatatata cggatatgag
     3361 gtaaagctgt atatacatta aaaacatact gaccacgcaa agcaacaagc tcccgatacc
     3421 tgtcacctgc atagcacgtg tcagataaag gcgtttgcgg agattagaaa tctgtgctgc
     3481 cgtaaccgcc gaatgatttt cacgatactg atccttcaac gtgcgtacta actgggcata
     3541 tgacagaaaa cgattggtat atgccagcat aatcagcgat atggctgaga acaataaagc
     3601 aggagttgtt aaatctattt ccatttttat aggtatttca aagttagaat attgcaaaga
     3661 taaagtaaat atcccgatat tctccttcct ttttacaatg aaaggaatat ctttgcaata
     3721 aaaataattc caataaacta atatgcaaac cataaaatta tacataaaag actggttggc
     3781 tatccatcct tatatccaac aacagactac agacagatat tttgtcgatc tggctaaccg
     3841 attatactcc acttgtacga taagagagat tcccgaatcc attaaaaaga agttatgtct
     3901 ttacaccgct gcctattttg aagatgtcat ttcaggttta ggtctatggc aagcattcat
     3961 caaaaagcat ctggaactat atgatacgtc acttcctttc tataccatcc gaccggatta
     4021 tataaaagat gagatcaatg aggaagatat ccgtttcatc atttggaaca ctttagagaa
     4081 ggctccatat aaacatctgt atatcaatcc gatggacagg aatatcgaag aaactgcaca
     4141 tttatttttc cggatattgg atgaagaata tgaaacggct cccgccaatg ccacgttaca
     4201 ggagttcttt atggatttca aaggaaaaga ggacgcaaac cataaactac gctggctgtt
     4261 cggacatact tatctcacag aaccatctgt acaagaatat attgcacagg ttacagaaac
     4321 cgacaaattc atcattccat gtggccccct tgccctgttt cttcatgaat ggattgacct
     4381 gctgaccaac ggagaaaccg aatgttggga agagatagaa ggactatacc ctgccattcc
     4441 cgaaatatcg gacgagatga aggaaaggaa ccaccatacc tatcaattgt tcacgcaagg
     4501 cacaaatggt gcccgtatcg tatatctgaa aagctataaa gaactacaca gtttccttac
     4561 ccaagtatta caatggccgg acgattccaa tcacactttg ccccaaatga aggaacataa
     4621 ggatttcatc atgatggtaa attccgaaaa aggtattcta ttggcgaagg atatatgcaa
     4681 atacatcagt gatcctctta acccgatgta tgatgccgca acggctgccc aagaggcatt
     4741 cagcctgctt actatcccga ccaaatgtcc gccggacctg atggaatatt taataaacaa
     4801 ccactatatc cccgatgcac aattccccga atttggtgaa aaggaactgg ttcaaaagaa
     4861 tgcggacttt atagcccgcc attccttatt gtattactac aggggagatt agaccctccc
     4921 caccgctact tcgttcacca aaggtctacc ttcaacaaag tctttcacgt tttgtagagt
     4981 agtatgagca atattcgtca ttgcctcttt ggtaaaaaaa gcctgatgtg aagttacaat
     5041 cacattattg aaagacagaa gacgagctaa agtgtcatca tcaataatct tatcagactt
     5101 atcttcataa aaataaggct cttcttcctc gtatacatcc agaccggcat atcccacttt
     5161 tttggtcttc agcccctcta tcaaggcatt ggtgtgaatc aactgcccac gccccgtatt
     5221 gataatcatc accccatctt tcattttact gatggaataa tcattaatca gatactttgt
     5281 ctgttctgtc aaaggacaat gcagggagat gatatccgaa ctatgataaa gttcatccaa
     5341 agtacaataa accacctgat gttcacgggc aaaattgtaa tcgggataaa gatcatatgc
     5401 aagaacattc ataccaaatc cacgtaatat ctgaattaaa atcttggcaa tcttacccgt
     5461 accgataatt ccggcagtct tgccatgcat atcaaatccc ataagtccat gcaaagaaaa
     5521 gtttccgtca cgtgtgcgca ttgtggcacg aggaatctta cgattgagtg acaacatcaa
     5581 tgccactgta aattcggcaa cagcatatgg cgaatatgcc ggtacccgta ccactttcat
     5641 cttacctgcc gttgccgcta aatccacatt attataacca gcacatctta aagccagcag
     5701 tttaacacca ttatccgcca ttgcccggat aacttcggca tcagccgtat cgtttacgaa
     5761 gatgcaaacc acatctactc ctttggtcaa caccacgtta ttcatattca aatggccttt
     5821 gtaatacctg atatcaaagc caaacttctc attagcctcc gtaaacgagt gttcgtcgta
     5881 gggtttcgtg tcgtaaaaag ctattttata agccataatt attttttatt tatagttcat
     5941 ataaataaca aaaacacgtc ccttactgtt cacatacaga cttatagttt tttcagttct
     6001 gtgtacaggc actgcacagg gagtcccatc acattgaagt aactacccga aattccacag
     6061 acaccaatga agcctatcca ctcttgtata ccataagaac cagccttatc catcggcttg
     6121 taaacccgaa tataataatc gatctcctca tcggacaatt ctgcaaacgt tacttctgtc
     6181 acagcagaaa aacttctctg agtcctggca gtagtcagac aaaccccagt tatcacctga
     6241 tgggtcttgc cagaaagctt ccacaacatc tgccgtgcat catcctcgtt atgaggcttg
     6301 cccatgacta caccgtccaa ccatacaatg gtatcagcag taataatcaa ttcgtccgga
     6361 tgcatgatat tccggtaagc agccgccttc tcgcaagcta tatacaaagg aatttcctct
     6421 gctttcaatg tatccggata ggtttcctct atgccgggta gtgtttttac ctcatatttt
     6481 atacctaagc cggataacaa ttctttgcgg cgcggagaat tggaagcaag gattatttta
     6541 tatttttcta aattttccaa catagctttt ctttatttca ttaccacccg aaggctcttt
     6601 catgagccat ccattttcct tgagccttca aaacctgttc caccacgtca cggccacatc
     6661 catagccccc attacgatga gaaatataaa cagctgtttc ttttatctca ggtgccgcat
     6721 cagcaggaca acaaggtagc ccacacaaac gcatcacttc ataatcggga atatcatcgc
     6781 ccatatagag tatctcctca tcctgcaatc catatttttc cttcaaatgg gcatactccc
     6841 gggtctttac cgcagcagcc agataaacat ccttgatacc cagcccctca taacgcttac
     6901 gcaccgcctc ggtatttcca ccagtaatga tggcaacatg cagcccgcat ttcacagcca
     6961 actgtaatgc atacccatcc ttgatattaa ccgtacgcat gggttcacca ttggggtgca
     7021 aataaatagt ttccgcactc aataccccat cgacatcaaa taccaatgcc tttattttct
     7081 ttaaatcata gtttatcata ccacttatga gttctttccc tctttatttg tctgaataac
     7141 agacaaaggg agatcatgaa tacttttact tatcttttcg tacaattcct gcaaagactc
     7201 ctcatccgcc aacatctcca aatgtttgct tattacgttt tcatcgtagc gtacagccgg
     7261 acctgtctgc gcctgtgtgg gagaaagttc atgtactttg ccggcagttt cgtctatcag
     7321 cggaagcatc acttcaaaag aaatcccctg cttttccagt atatgtgaac ttaatgcata
     7381 catatgatta gcaaaattac aagcaaagac tgccgccagg tgcaaatgcc tacgttgacc
     7441 ggaagtcact tcatacactt taggactgag acgaactgcc accatacgca gcactcccac
     7501 ttctgccgga gcagatgctt ctataaaaaa aggtacggta ttgaaatcaa cttcacgctg
     7561 cttgctaaaa gtctgcatag gataaagtac cccatagcgt tttaccaacc ccttccataa
     7621 atccataggc atactacccg ccgtatgtac aaacaaagcc tgctcccttc ctttcaccaa
     7681 tacaggagcc aattgtcgca aaactgcatc tttcagcgct acaatataca aatcggcatc
     7741 ccgacgtatc tcatccggca caattgtgta gtctactaaa agtctgtcag ccaatgcaga
     7801 agcagactcc tctgtacggc tgtatacctg caaaataaga caccctgcct tttgtaaagc
     7861 gattcccaaa tgggtagcca cattgccagc tcctatcaga actattttca tcatcgggtc
     7921 gaaactaaat ataaaataac tcctaacaac aacaaagccg ccggcaacaa ataagcagac
     7981 atctgcccca acaaagctat caccaaactg atattcaata tcagccatat acccgccaat
     8041 acaattccta ctgacttatc ggccttgaac caaaggaaaa taacagctgc atacagtaac
     8101 agattgtctt tctgcataac ccatggcaac ccgtgtgagg caaatcctat aaacttatcg
     8161 atcagataaa gcatacccat cacaatgaga aacaccgcag aagctttata cgtatcctta
     8221 tgattgacag cagccacgtt tacttgcctc caaatttatt gatgtgaatt ttctcccatt
     8281 gcaaatggtc ctcattaaaa ggcttgcgtt ccatgccctt atgtcctacc gctataatgg
     8341 aaaccacctg caactgcaac ggaatatcaa gcagcgtatg cacgtattca cccgagggca
     8401 tcccggtagc ggtaaaacgt tcacgcacct gtatccaaca acttcccaac cccaaatctt
     8461 ctgcctgcaa ctggatcatt atggaagcaa ttgccgcatc ttcaatccaa acatcactag
     8521 ccaacggatc agccatcaca actacagcca tagcagcatc cgctagaaaa gctgccccca
     8581 tctccttaca atgggaaagt ttttccagca tatccttatc atctaccaca agaaactgcc
     8641 agcaattgct acgtttagaa gacggagcca tcaaagcagc cttcaacaaa gcaaccacct
     8701 cttcctgtgt caactcttga tccgtgaact tacgcatact gcgtctgttc tttattaagt
     8761 cactaaattg ttccataata tactcagtta atttattttt ctgcacaaat atacaactag
     8821 aatgtggatt gataaacaaa aaacaataaa tttgcaatta gagatgcctg tcagattaag
     8881 tacatatcgc aaaggaaatg ccattccccc tctgcctgga acaaacattt tccattctac
     8941 cgagttattt catgtctttg aaatgactcg gggatacgaa cctctgctta tcgtagccta
     9001 tataggaaac cgtcctgtag gcaaactgct ggctgtcatc cggaagagta tgcgcttgtt
     9061 cccccccgca atcatcaaac gatgcgagat ttatggcaca ggcgagtatt ttgatgaaga
     9121 acagaataag gaagacctgt tcggggaaat gttggaacat ctcaccaacg aagtattatg
     9181 caaatcgttc ctcatcgagt tccgcaactt ggaaaatccg ctattcggat acaaagcttt
     9241 cagaaagaac aactatttcg ccattaattg gctaagagta cgtaactcac tgcacagtaa
     9301 agtcccttac gaacggctga gcatgtctcg caaaagacaa ataaacaaag cgttgagaaa
     9361 cggtgccatc atggaagtag ccgacaatga gaaagatatt caagatttct cacgaatgtt
     9421 gaaaaaagcc tattcctcac aggtaagaaa acatttcccg gacatcggct ttttccggct
     9481 attagcatgg caaaacccag aaaaagaatt agccaaagtg tttcttgtga aatataaagg
     9541 caaaatcata ggtggttcta tctgtctttt ctcaaaagaa agtgcttatc tgtggttctc
     9601 aggaggtatg cggaaaacct atgcttttct ttaccccggt attctagccg tatgggcacc
     9661 tattacctat gctcacgaaa aaggatatgc acatttggaa ttcatggatg caggattacc
     9721 gttcaaaaag cacggttaca gggactttat actccgcttt ggcggcaagc agagcagtac
     9781 acgccgctgg ttccgcttca gttggaagtg gctgaacaaa ctcttgtgca aattctatat
     9841 ttaattcatt tttgtctttt tgtctaaagt gttgtgaagc atctcgcaaa taagaaataa
     9901 aattgaagaa atatttcttt atttaactcg aaattacttt ctttgtgcag ttttatctga
     9961 aaacttgagt ataaaaccaa actattaaaa ttataagatc atgaaaatct cacacattga
    10021 acacctgggc attgccgtaa agagcattga agaggccctg ccgtattatg aaaacgtatt
    10081 aggtctgaaa tgctacaata tcgaaacagt agaggatcag aaagttaaaa ccgcttttct
    10141 gaaagtaggt gatgttaaaa tagaactgct ggaacctaca agccccgaaa gcactatcgc
    10201 aaagttcatt gaaaaaaata atggcaacgg tggtatgcat catttggctt ttgcagtgga
    10261 agatggtgtg gcaaatgcgt tagccgaagc ggaaaccact ggcatccgtc tcattgacaa
    10321 agctccgcgt aaaggtgctg aaggtttgca aattgctttt ttacatccca aatcaacttt
    10381 gggcgtcctg actgagcttt gcgaaaaacc ataaaacacg agatctgact attcacgatt
    10441 gaaatcagtg tatttagtct ggttcaagcg taaatagaaa tattttttaa tcgtaaattg
    10501 taaaatcata agtaaaatga gcaatcaact tgaaaaaata aaagagctta tcgaacgccg
    10561 ggctacagca cgcatgggtg gaggtgataa agcaattgca aaacagcatg aaaaaggaaa
    10621 atatacagcc cgcgaacgca tagccatgtt gctggatgaa ggcagtttcg aagaaatgga
    10681 tatgtttgtg gaacacagat gcaccaattt cggcatggag aaaaaacatt atccgggcga
    10741 cggtgtagta acaggttgtg gtaccataga aggacgttta gtttacatct ttgcacagga
    10801 tttcactgtt tctgccggtt ctctgtcaga aacaatgtct ctgaaaatct gcaaagtaat
    10861 ggatcaagcc atgaaaatgg gtgctccctg tatcggtatc aatgactcgg gtggcgcacg
    10921 tattcaagaa ggtatcaatg cgctggccgg ttatgctgaa attttccaac gcaatattct
    10981 tgcttcaggt gttattccac agatttcagg tattttcggt ccttgtgcag gcggagctgt
    11041 ttactctcct gcgctgacag acttcacatt gatgatggaa ggcacatcat acatgttcct
    11101 taccggaccg aaagtggtaa agactgttac aggtgaagat gtaagccaag aaaacttagg
    11161 tggtgcaagc gttcattcta ccaaatccgg tgttactcat tttactgcca agacggaaga
    11221 agaagggtta gccatgatcc gcaaattgtt aagctatatt cctcaaaata atctggaaga
    11281 agctccctat gtagactgta ccgatcctat cgaccgtctg gaagactctt tgaacgaaat
    11341 tatccccgac agccccaaca aaccatacga tatgtatgag gtgatcagcg ccatcgtaga
    11401 taatggtgag tttttggaag tccaacctca ctacgctaaa aatatcatca ttggtttcgc
    11461 acgtttcaac ggacaatctg taggtattgt tgcaaaccag ccaaaatacc tggcgggtgt
    11521 acttgacagc aatgcgtcac gtaaaggtgc gcgttttgta cgtttctgcg acgctttcaa
    11581 tatacctctt gtttcattgg tagatgttcc gggattcctt ccaggcacag gacaagaata
    11641 caacggcgta atcctccacg gcgccaagtt gctgtatgct tacggcgaag cgactgtacc
    11701 caaagtaaca attaccctgc gtaaatcata cggcggatct cacattgtaa tgagctgtaa
    11761 acaacttcgc ggtgatatga attatgcatg gcctactgcc gaaatcgccg ttatgggtgg
    11821 tgcaggtgca gtagaagtat tatacgcccg cgaagccaaa gaacaggaaa atcctgccgc
    11881 attcctagcc gaaaaagaag ctgaatacac caagctgttc gccaatcctt acaatgctgc
    11941 caaatatggc tatattgatg atgtgattga accgcgtaat acccgtttcc gcatcatccg
    12001 tgcattgcaa cagttgcaaa ctaagaaatt aaccaatccg gctaagaagc atggtaatat
    12061 tcctctttaa ttaaaaatta aaaattgaga attgaacatg aagaaattaa atataggaat
    12121 attcctttct ttgctgctga tggtgggttt atgttcttgt ggagaacaga aatcaaacac
    12181 caagctggta ctgaatgaag tgctgattga aaatgaaagc aatttccaag atgactacgg
    12241 agtacacagc gcatggattg aaatattcaa tagatcattt ggtagcgcag accttgccgg
    12301 ttgtttactg aaagtgagca gccagcctgg agatactgct acttatttta tccctaaagg
    12361 tgatgtattg actttgatca aacctcgcca gcacgctttg ttctgggcag atggtgaacc
    12421 taaccgtggt actttccaca ccaacttcac cctgaatgcc gcaacgaaca attggatcgg
    12481 cttgtatgat tcaggcaaga aattattgga tcagattata gttcctgcag gtacattaca
    12541 ggcaaaccaa tcatacgcac gtgtcagcga cgctgcaaat gaatgggaag taaaaggttc
    12601 tagtgcagac aagtatgtaa ctcctagcac taacaacaag actatcaaca gcaacgctaa
    12661 gatggaaaag tttgaagaac atgacagtgt gggtattggt atgtccatat cagctatgag
    12721 tgtcgtattc gtaggcttgc tccttctgtt tattgctttc aaagttatag gccgtatttc
    12781 tgtcaacctg agcaagcgca atgccatgaa ggtaaaaggt attaccgaca aacaagaagc
    12841 caaagaaaag aaactgggtg aagctccagg cgaagtattc gccgcaattg ccatggctat
    12901 gcacgaaatg caaagcgatg tacacgatgt agaagaaact gttcttacca ttactcgtgt
    12961 aaaacgtagc tattcaccgt ggagttctaa gatttatacc ttgcgtgaaa ctccccacaa
    13021 aaagtaagtc accaataaaa agataaaacg atgaaagaat ataaatataa gattaacggt
    13081 aacatatata aggttgccat tggagatata gaagataata tcgctcatgt tgaagtaaac
    13141 ggcactcctt acaaagtaga aatggaaaaa gccccgaaag ctgtagtgaa accggtagtt
    13201 cgtcctgcat caaccagccc tgctccggct ccaactacag tagtaaagcc tgctgcaact
    13261 tctacaggaa aatcgggcgt taaatctccg ttgccaggtg taatccttga tattaaggta
    13321 aatgttggtg ataccgtaaa aaaggggcaa accatcatta tccttgaagc tatgaagatg
    13381 gagaataaca tcaacgcaga caaagacggc aagatcaccg caatcaatgt aagtaaagga
    13441 gaatccgttc tcgaaggtac tgaccttgta attattgaat aatatgggag aatttatcaa
    13501 ctttttaggg aataacctag ctgacttttg gacatatacg ggttttgcca atgctactgt
    13561 tggtcatatc gtaatgatcc tgataggttt attcttcata taccttgccg tggccaagga
    13621 atttgagccg atgttgctca ttcctatcgg ttttggtatc ttgatcggta atattccttt
    13681 caacatggaa gccggactga aagtcggcat ctatgaggaa ggttctgttc ttaatatttt
    13741 atatcaagga gttacctccg gatggtatcc accacttatc tttttaggta tcggtgcaat
    13801 gacggatttc tcggcattga tttcaaatcc taaactgatg ttgattggtg ctgccgcaca
    13861 gtttggtatt ttcggtgcat acatgattgc attggcaatg ggctttgatc cgatgcaggc
    13921 tggtgctatc ggcatcatcg gtggtgcgga cggtccgaca gcaatcttcc tttcatccaa
    13981 actggcgcct aacctgatgg gagctattgc ggtatcagcc tattcataca tggcattggt
    14041 accggttatc cagccgccta tcatgcgtct gctcactacc aagcacgaac gtttgatccg
    14101 tatgaaacca ccacgcgtcg tttctcatac agaaaaagta atgttcccta tcattggttt
    14161 gttacttact tgttttctgg ttccgtcggg tctgcctcta ttgggtatgc ttttctttgg
    14221 taacttattg aaagaaagcg gtgtaacccg tcgcttagca gaaactgccc gcggtccgct
    14281 gattgatacc attaccatct tattaggatt gacagtaggt gcttccacgc aagcttcaga
    14341 gttccttacc attgattcga tcttgatttt cgcgctgggt gcattgtcat tcatcattgc
    14401 tactgcttct ggagttatct tcgtgaagat attcaacttg gtattaggta aggataacaa
    14461 aatcaacccg cttatcggta atgccggtgt atctgctgtt cccgactcgg cacgtatctc
    14521 tcaggttatt ggtttggaat atgatcctac caactacttg ttgatgcatg ctatgggtcc
    14581 caacgtagct ggtgtaatcg gttctgccgt agcagccggt attttacttg gattcttgat
    14641 gtaattcatt gaacaacaac aaataaaatc ctcttcaact aatatgtgga agaggatttt
    14701 ttattgatat agattaagaa atgaatgatt tattatgaat tttgaatgat tagttatata
    14761 agatatgctg aaaaacatat aaatttgccg ccgtaaaacc aaactaaatt aaacgaagat
    14821 ggaaaagaaa acagttaagt accatattcc ccaacacgga atatatatgt acgcacgtac
    14881 taattctggg aaaactgaac tcattgtcct aaacagcacc aatgccgaac aagtggtggc
    14941 taataaccac taccgcataa tgacaaatga ctcaaaaagc ggtaaagaac ttatcagtgg
    15001 caaaaaaatt gaccttacca aaaatatgac agtcggtgca cgtcaatcat tgattattga
    15061 attataattg ttttttaagg taagaaggta aaatgagaag gtaagaataa aggcggcttt
    15121 ataaagggtc gcctttattt atatctcttc tacctctttt atttgcgtga aacaattgtc
    15181 cctgtagctt gataagtagg cataaccaac atttctgcaa tctgcatata ttctggtaca
    15241 gaagcagcaa aataaacagt ttccgcaata tcatctcccg tcaatggacg aataccttta
    15301 tatacattat ccgccttttc cttatctcct cggaaacgaa taactgaaaa atttgtttct
    15361 accaaccccg gtttaatatt agtcactctc aatggagtat caactaaatc tatacgcagt
    15421 ccatccgata aagctttcac agcggccttt gtagcacaat acacactacc tcccggataa
    15481 gcagcatctc cggcaataga accaatatta ataatatgtc ctcgtttacg ttccaccatt
    15541 cccggtacaa tcaggcgtgt cattgccagc aaagccttaa cattagtatc tatgacaata
    15601 tcccactcat ccagactacc ttcctgttct ttatccgtac cgataaccaa cccagcatta
    15661 ttcaccagta tatcaatgga ttgccattcc ttgggtaatg attccaaagc agacgttgcc
    15721 gccttacggt cgcgcacgtc aaaaggaagc aaatatattt ccgtaccata ttgcttttct
    15781 aattcttctt tcaatgcact cagtttattt acgttacgag catttaaaat caaacttgct
    15841 ccctgtgaag caaacttgcg agcgcatccg gcac
//
