LOCUS       gnlProkkaPADNJICE_80   15006 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PADNJICE_80.
ACCESSION   gnlProkkaPADNJICE_80
VERSION     gnlProkkaPADNJICE_80
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 23:12:45
            Original ID  :: gnl|Prokka|PADNJICE_80
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15006
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15006
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4451:6223]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4452..6223
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..15006
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15006
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             109..855
                     /locus_tag="ctg80_1"
                     /transl_table=11
                     /translation="MYQFFIQPDSIKEEEIWIADPQDVNHIRNVLRMKKGEKVSLCCEA
                     KGKEYICGIEEIESDIVKAAIIDINGESRELPVKITLFQGLPKSDKMELIIQKAVELGA
                     AEIVPMATKRAVVKLDAKKAAKKVQRWNEIAKSAAKQSKRGLIPEVKPVMSFKEAVEYG
                     KSMDMLLIPYEDAKGIAHSREVVETVKDKKSLGIYIGPEGGFPEEEVSFAMKAGAEPVT
                     LGHRILRTETAGMTLLSILMFMLEED"
     CDS             942..2051
                     /locus_tag="ctg80_2"
                     /transl_table=11
                     /translation="MAGSSFGTLFCMTTWGETHGKGVGVVVDGCPAGLSLCEEDIQKYL
                     NRRKPGQSKYTTKRKEDDKVEILSGVFEGKTTGTPISMAVFNKDQHSKDYSAIKDIYRP
                     GHADYTFDKKYGFRDYRGGGRSSGRETTARVAAGAVAAKVLKELGIEVFAYTKAIGPVQ
                     IDENRFSKEERDKNALYMPDAQAAAQAEEYLQEKMKELDSCGGIVECVITGMPVGVGEP
                     VFDKLSANLGKAILSIGAVKGFEIGDGFAAAASAGSENNDDFYNDNGTVKKKTNHAGGV
                     LGGMSDGSVITFRAAFKPTPSIAQPQQTVNRDGKDTEIVIHGRHDPIIVPRAVVVVETM
                     AAVTVLDLLLQNMGSRLDSVKNFYENEKK"
     CDS             2120..3262
                     /locus_tag="ctg80_3"
                     /transl_table=11
                     /translation="MYKLLTKDGMAKRGEFETVHGTIQTPVFMNVGTVGAIKGAVSTDD
                     LRTIGTQVELSNTYHLHVRTGDKLIKQFGGLHKFMGWDKPILTDSGGFQVFSLSGLRKI
                     KEEGVYFQSHIDGHHIFMGPEESMQIQSNLGSTIAMAFDECPSSRADRTYIQNSVDRTT
                     RWLERCKKKMQELNSLPDTVNPHQMLFGINQGGVFADIRIEHAKRISELDLDGYAVGGL
                     AVGETHDEMYYILDEVVPYLPENKPTYLMGVGTPANIIEAVDRGIDFFDCVYPSRNGRH
                     GHVYTHHGKLNLFNKKFELDPRPIEEGCQCPSCRTYSRAYIRHLLKAKEMLGMRLCVLH
                     NLYFYNHLMEEIRGAIDEHRYKEFKKTTLEGFLTPEEEYR"
     CDS             3296..3616
                     /locus_tag="ctg80_4"
                     /transl_table=11
                     /translation="MLLAQSASASSSITMIIAYVILFGAIIYFMTIRPQKKQQKAADEM
                     HAGMQAGDSVLTTSGFYGVIIDIMDDTVIVEFGNNRNCRIPMQKDAIAAVEKPNLTKTE
                     EE"
     CDS             3972..4352
                     /locus_tag="ctg80_5"
                     /transl_table=11
                     /translation="MDGISYKKWMERAAGLFLSALIAVLLTMLFLAVFAFAMLKGNLSA
                     SVEKIGLIVMSVMACFVGGFLCGKKNMKKRYLWGLGVGVLYCLFFGVIRVGMGQAFVTD
                     TTAFFTMMLYCAAGGMLGGMLS"
     CDS             4452..4598
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_6"
                     /sec_met_domain="TIGR03973 (E-value: 5.4e-23, bitscore:
                     70.6, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 2.7e-22, bitscore: 68.4,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVKTLTGNKTYGTTMCKGGCGECQTSCQSACKTSCTVGNQTCE
                     SNK"
     CDS             4859..6223
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_7"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.6e-33,
                     bitscore: 104.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.5e-16, bitscore: 49.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3e-14, bitscore: 43.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.6e-20, bitscore:
                     63.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYKNNGYNIVMDVCSGAIHVVDDVTYDVIALYEEKSLEEIEN
                     ELSYSKEDIEEAYKEVTSLKEEGLLFTEDIYEDYIKEVKSRKTVVKALCLHIAHDCNLA
                     CRYCFAEEGEYKGHRELMSAKVGKAALDFLVANSGNRHNLEVDFFGGEPTMNFGVVKEV
                     VEYGRSLEEKHNKHFRFTLTTNGVLLNDEIMEFANKEMDNVVLSVDGRKEIHDYMRPTR
                     NGKPSYDLIMPKFIRFAESRHQQKYYVRGTFTNRNLDFSKDVLHLADLGFEQISMEPVV
                     GQPEEPYAIQEKDLPQIFDEYDRLAKEMIKREKAGKGFNFFHFMIDLTGGPCVAKRLSG
                     CGSGTEYLAVTPWGDLYPCHQFVGEEKFLLGNVFDGIKRTDICDEFRSCNVYTKKKCKD
                     CFARFYCSGGCPANSYNFHGTIDDSYDLSCDMERKRVECAIMIKAALADTEGEEE"
     CDS             6224..7999
                     /locus_tag="ctg80_8"
                     /transl_table=11
                     /translation="MEKWFIASKRADFNKIGEIFHISPVTARLMRNRSLTTVREMQRYL
                     YGSLSDLYDSHLLKDADKGAEIIKEKIETGKKIRIISDYDVDGVSSNYILYQGLKRCGA
                     DVDYKIPDRVEDGYGINEHLIEKAAGDGIDTIITCDNGIAAAEQIAYGNSLGLTLIVTD
                     HHDIPFQRQEDGSISYNLPSAAAVINPKQKDCPYPFENICGAVVVYKFIQVLYDLFGID
                     RRESEAFLEIAAMATVCDVMPLCDENRIIVKEGLQRIQHTNITGLQALIEANHLEEKKI
                     SSYHFGFILGPCINASGRLTSAKDALELLLCEDKELCRQKAEALTQLNAERKEMTANGV
                     KAAKEYLESTGHGNDKVLVVYLPNCHESIAGIIAGRMKEHYHKPVFVITRTKEGLKGSG
                     RSIEAYHMYKEMNKIKECFDKFGGHPMAAGFSMQEDRLEEFREKLNANATLTEDDFAEK
                     VHIDVALPISYLSESLINEFELLEPFGNENTKPLFAQKDLYIKGMRVLGTTGRCLKLFL
                     SDANGTSIDAMYFGESDGFLEELISFCGKEEAQRIQKGLSHHIWMDVTYYPQVNEWRGQ
                     KNIQIVIQNYRFKNL"
     CDS             8169..9014
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179:hydrolase (Score: 177.4; E-value: 6.7e-54)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg80_9"
                     /transl_table=11
                     /translation="MEQEKKQPDVRLIGLDLDGTTLTSDKVLTPHTKEVLEKCLAEGIQ
                     VLPATGRVKSGIPEYLTQIEGMRYVILSNGASVLDLKEDKVLYQNCIPWERALELFDVL
                     ETYDTFYDIYALGAGWCEARFYDNVENYGIEKHIEKLVRTSRNRIDDLREWMKENKAPV
                     EKINMFFAKEEDRQRAFRELGKIEDLAVTCSLGNNLEINGATCNKGDAMLNLGKILDIP
                     IESIMACGDGNNDFEMVKMAGVGVAMKNGEESLKEVADFVTKTNDEEGVAYAIEHFCNV
                     "
     CDS             9117..9674
                     /locus_tag="ctg80_10"
                     /transl_table=11
                     /translation="MPDLGAERVDKVKKLEDYVINIPDFPKPGIIFRDITSILRDPEGL
                     KLSVHELMHCLEGTEFDVVVGAESRGFLFGMPLAYNKSKGFVPVRKKGKLPRETVSKEY
                     ALEYGTAEIEIHKEDIRPGQRIVFVDDLLATGGTAKAAIDLIEELGGVVVKVLFVMELE
                     GLHGRDVLKGYDVESVITYPGK"
     CDS             9872..10741
                     /locus_tag="ctg80_11"
                     /transl_table=11
                     /translation="MEHLNLLQRIEKKSSEFSKGQRRLAQYITENYDIAAYLTASKLGK
                     KAGVSESTVVRFAYQLDYEGYPELQKAIQVIVKTNSNSIQRMSLSSKRYQEKGVLKSIL
                     YTDAERLRDTIQSGVDEEEFNRSVMLINDARRLYILGARSAAYLAGLMGYYFKMMFDNV
                     IIVDANSTSETLEQIYDISDKDVMMGITFPRYSKRTICALQYAKNHGAKTIALTDNMQS
                     PIVEYADCKLIAKSDVMTIVDSLVCPLSVVNAMVTAIALLRKDDVEKRLMALEELWNEY
                     DVYNRSLL"
     CDS             10741..11982
                     /locus_tag="ctg80_12"
                     /transl_table=11
                     /translation="MNKVIIVGGGAAGMMAAISASKEGKKVCILEKNEKLGKKLFITGK
                     GRCNITNACPADEFLTHVVTNPRFLYSTFSQFNNEDMMDYLEEIGLPIKTERGQRVFPQ
                     SDRSSDVIDALKKQCKKGGVQIYYHTEVKELLFDEEKENCVGVLLSDGKKMMGDSVILA
                     CGGFSYASTGSNGSGYTLAKQAGHKIKSIEPSLVPFEMKEMWCKDLMGLTLKNIGVRIK
                     AKKKTVYEGFGEFLFTHFGVSGPLVLTASTCLGKYQKELEAGELKLILDLKASLTPEQL
                     DKRFLREFDTYRNKNISNVMERLLPKKMIPVFLEEAQIPEDKKIRDISKKERRHMIELM
                     KNFEMHITGVRGFNEAIVTRGGVNVKEINPSTMESKKVKHLFFAGEMMDLDAVTGGYNL
                     QIAWTTGYVAGKNA"
     CDS             12118..12783
                     /locus_tag="ctg80_13"
                     /transl_table=11
                     /translation="MYSIAIDGPAGAGKSTIAKAIAEDIGFIYVDTGAMYRAIALYFLR
                     KGIDGHDRKLVAAECPNIHVTLEYDEEGKQQVILNGENVTGYIRKEEVGKMASVTSAVP
                     EVRAALLDLQRDMAKTSDILMDGRDIGTNVLPDASLKIYLTASADVRAKRRYDELKEKG
                     ADCDIEQIKTDIIARDKQDMEREIAPLCQAEDAILVDSSDMSIPQVIDTIISEFKKIK"
     CDS             12801..14684
                     /locus_tag="ctg80_14"
                     /transl_table=11
                     /translation="MKINIAKSAGFCFGVKRAVDTVYKESSKKNVYTFGPIIHNDEVVA
                     DLERQGVHVINDSEDFKSLSEGTIIIRSHGVSKAIYDEILNAGLDLVDATCPFVRKIHK
                     IVERESGDGRVIIIIGNNHHPEVEGIMGWCHTHPIVIENREQAEGIELDADTKISIVSQ
                     TTFNYNKFQDLVEIISEKGYDINVFNTICNATEERQTEVRELAKKSDAMIVIGGRHSSN
                     TQKLFEISKKECSNTFYIQTKNDLNMEDFSNIGMLGITAGASTPNNIIKEVHESMAEMS
                     FDQMLEESFKTIRNGEVVQGTIIDVKEDEIILNIGYKADGIISRNEYSNDQNLDLTTVA
                     KVGDEMEAKVLKVNDGEGQVLLTYKRLKAEKGNKRLEEAFNNHEVLKAPVAKVLDGGLS
                     VVVEETRVFIPASLVSDTYEKNLKKYDGQEIEFVITEFNPRKRRIIGDRKQLLVAEKKA
                     KQEALFAKIEAGMTVEGTVKNVTDFGAFIDLGGADGLLHISEMSWGRVENPKKVFTVGE
                     KLNVLIKDIQGEKIALSLKFPETNPWLHADEKYAVGNEVTGKVARMTDFGAFVELEPGV
                     DALLHVSQIAKEHIEKPSDVLKVGQEVTAKVVDFKKDDRKISLSIKALDNE"
ORIGIN
        1 cgtctgtagt tcgcttaatg aattaaatag taaattgaca tattttttga aagcggttat
       61 gatatattat gtctgcctta tagggcaaag aatgaagtgg aggagtttat gtatcagttt
      121 tttatacagc ctgatagtat taaagaagag gagatttgga ttgcagaccc gcaggatgta
      181 aatcacattc gtaatgttct ccgtatgaaa aagggagaaa aagtttctct ttgttgcgaa
      241 gcaaagggaa aggagtacat ttgtggtata gaagagatag aatcagatat cgtcaaggcg
      301 gcaattattg atattaacgg agagtcgaga gaactgccgg taaagattac gctttttcag
      361 ggacttccaa agagtgacaa gatggaactt atcattcaaa aagcggtaga actcggggcg
      421 gcagagattg tgccgatggc aacaaaaaga gcggttgtaa agcttgatgc gaagaaggca
      481 gcaaagaaag tacagcgatg gaatgagatt gcaaaaagtg cggctaagca gtcaaagaga
      541 ggtctgattc cagaagtaaa gcccgtaatg tcttttaaag aagctgtgga atatggaaag
      601 agtatggata tgctactcat tccgtatgag gatgccaagg gaatcgcaca ttccagagaa
      661 gtggtagaaa cagtaaagga taaaaagagt ctgggaattt atatcggacc ggaaggtggt
      721 tttccggaag aagaggtttc ttttgcgatg aaagcaggag cagaaccggt tacacttggg
      781 caccgcattt tgcggacgga aacggcggga atgacattac tttctatatt aatgtttatg
      841 ttagaagaag attgatttgg tgtagatagt agaaatttaa ttgataaaaa gtcaaacaga
      901 ggatactctg tttgacgata gaattttaac aggaggacaa aatggcaggt tcatcatttg
      961 ggacattgtt ttgtatgaca acatggggag aaacacacgg aaaaggtgtg ggtgttgtag
     1021 tggacggttg tccggcaggc ctttctcttt gtgaggagga tatacagaag tatttgaata
     1081 gaagaaagcc gggacagtca aagtacacaa caaagcgaaa agaagatgat aaggtggaga
     1141 ttttatcggg agtttttgag ggaaagacaa caggaactcc aatttctatg gcggtattta
     1201 ataaagacca gcattcaaaa gattactctg caatcaagga tatttaccgt ccgggccatg
     1261 cagattatac atttgataag aagtatggtt tccgtgatta tcgcggtggc ggccgttctt
     1321 caggaagaga gacaacagca agagtagcag caggtgcagt agcagcaaaa gtattaaaag
     1381 aacttggcat tgaagtattt gcttatacaa aagcaattgg gccagttcaa attgatgaaa
     1441 atagattttc aaaagaagaa cgagataaga acgcattata tatgccggat gcacaggcag
     1501 cagcacaggc ggaagagtat cttcaggaga aaatgaaaga gttagattcc tgtggtggca
     1561 ttgtggaatg tgtaattaca ggaatgcccg tcggtgttgg tgagccggta tttgataaat
     1621 taagtgcgaa tcttggaaaa gcaattttat ctatcggagc agtaaaaggc ttcgaaatcg
     1681 gagatggatt tgcggcggca gcaagtgctg gttctgagaa taatgatgat ttttataatg
     1741 ataatggtac ggtgaaaaag aaaacgaatc atgcaggtgg tgtgcttggt ggaatgagcg
     1801 atggttcagt aattacattt cgtgcagcat ttaagccaac tccatcgatt gcacagccac
     1861 agcagacagt aaatagagat ggcaaagata cagaaattgt aattcacgga agacatgacc
     1921 cgattattgt gccaagagca gtcgttgttg tagagacaat ggcagcggta actgttcttg
     1981 atctgctgct tcagaatatg gggagccgct tagatagcgt aaaaaacttc tacgaaaatg
     2041 agaaaaaata aggatagagg ttgtacattt gctttgttta tgataaaatc aaatttatgt
     2101 gtaaagttaa ggagagtata tgtataagtt attaacgaaa gatggcatgg ccaaacgagg
     2161 agagtttgag acagtccatg gtacgataca gactcctgtt tttatgaatg taggaacagt
     2221 aggagcaatc aaaggtgctg taagcacgga tgaccttcgt acaatcggaa cgcaggtgga
     2281 gctgtctaat acctatcatc ttcatgtaag aacaggtgat aaactaatca aacagtttgg
     2341 cgggcttcat aaatttatgg gatgggataa accaatcctt accgattctg gcggatttca
     2401 ggtgttttct ctgtcaggtc ttcgaaagat aaaggaagaa ggcgtatatt tccagtcaca
     2461 tattgatgga catcatattt ttatgggacc ggaagaaagt atgcagattc agtctaatct
     2521 tggttctacg attgcgatgg catttgatga atgtccttca agtcgggcag acagaaccta
     2581 cattcagaat tctgttgaca gaacaacaag atggttagaa cgctgtaaaa aaaagatgca
     2641 ggaattaaac agcctgccag ataccgtaaa tccacaccag atgttatttg gtattaatca
     2701 gggtggtgtt tttgcggata tccgtatcga gcacgctaaa agaatcagtg agcttgattt
     2761 agatggttat gcagttggcg gacttgcagt aggagagaca catgatgaga tgtactatat
     2821 ccttgatgaa gttgttccgt atctgccgga aaataaacca acttacctta tgggtgtagg
     2881 aaccccagca aatattattg aggcagttga cagaggaatc gacttctttg actgtgtata
     2941 tccttccaga aatggaagac acggacatgt gtatacgcat catggaaagt taaatctttt
     3001 taataagaag tttgaattag acccccgccc aatcgaggaa ggatgccagt gtccgtcatg
     3061 tcggacatac agcagagcct atatcagaca cctgctcaag gcaaaagaga tgcttggaat
     3121 gcgtctttgt gttcttcata acctgtattt ctataatcat ttaatggaag aaatacgtgg
     3181 agcaattgat gaacaccgct acaaagagtt caaaaaaacc acattagaag gttttttgac
     3241 accggaagaa gaataccggt aatatattat atagaagaat aacggaggta aggacatgtt
     3301 attagcacag agtgcgagcg caagctcatc tattacaatg atcattgcat atgtcattct
     3361 ttttggagcg attatctact ttatgacaat ccgtccacag aagaagcagc agaaagcagc
     3421 agacgagatg catgcaggaa tgcaggctgg agacagcgta ttgactacaa gcggattcta
     3481 tggcgtaatc atcgacatca tggatgacac tgtaatcgta gaatttggta acaaccgtaa
     3541 ctgcagaatc ccaatgcaga aagatgctat tgcagcagtg gagaagccaa atcttacaaa
     3601 gacagaagaa gagtagtttc ggttagcggg acagacgaaa aatgaaaaag cagatatcct
     3661 atatttgtga ctctatcact gcgggttgaa tgttcgcctc cgggttcaca ttcaatcctc
     3721 gctaaggcca caaatatagg atatctgttt tttgctaaat tgaaagtact ctccagttta
     3781 acaaagacag aaattaagag accgccaata tataaaaaat gcgccttaga gcaagctctt
     3841 aatgcggacg agcattaaga gcgcagtgat acgaagcatt ttttatatat tggcggtctc
     3901 ttaatttcgt ctcgcttgtt ctaaacagag aacccttttc ataggctata aaaaagcctt
     3961 tggtgcagcc tatggatgga atttcgtata aaaaatggat ggagcgtgca gcaggcctgt
     4021 ttctttctgc attaattgca gtattactca caatgctatt tttagcagtg tttgcatttg
     4081 ccatgttgaa aggtaatctt tccgcttccg tagaaaaaat tggtttaatt gttatgagtg
     4141 tgatggcttg ttttgtcggg ggatttttgt gtgggaaaaa gaatatgaaa aaacggtatt
     4201 tatgggggct tggcgtaggt gttttatatt gcttgttttt tggagtaata cgcgtcggga
     4261 tggggcaggc atttgtgaca gatacgacag cattttttac aatgatgctt tattgtgcgg
     4321 caggaggaat gcttggagga atgttaagct aaaaagttct tttcttacgg gagggtttgt
     4381 gttataataa cctacaaagt gtcatcttag atgctttaca tactagatca tgaagtgagg
     4441 aggcgttatt aatgaaacgt gtaaagacac tgaccggaaa caaaacttac ggtactacaa
     4501 tgtgtaaagg tggatgtggc gagtgccaga catcctgcca gtctgcctgc aagacatctt
     4561 gtacagtagg taaccagact tgcgagagta ataaataatt agagagcaca acaggaagaa
     4621 tgcttcctga tatatgcttg aagtagggtg aactgtcttt tttgtcagtt caccttatct
     4681 cttgtatgga aaagtatgtt tgcagagatt actttattgt aagttgaaaa tattgtatac
     4741 aggaatgttc tgtattatat atctatttta aagttagcag gacatatctt caaattaaaa
     4801 atatatttta gaaaattaag tataaaaact ataaaagaaa tagaaaggga tatttaacgt
     4861 gattcaccag tataaaaata atggatataa tattgtcatg gatgtgtgca gtggtgccat
     4921 tcatgttgtt gatgatgtga cttatgatgt cattgcttta tatgaagaaa aaagcttgga
     4981 agaaatagaa aatgaacttt cttacagcaa ggaagatatt gaggaagcat ataaagaggt
     5041 aacttcttta aaagaagagg gacttttatt tacagaagat atttacgaag attatattaa
     5101 agaggtaaag agcagaaaga cagtagtaaa ggcactttgc ctgcatattg cacatgattg
     5161 taatcttgcc tgccgctact gttttgcaga agaaggagag tataaaggac accgtgaact
     5221 tatgagtgca aaggttggaa aggctgccct tgatttcctt gtagccaatt ctggaaaccg
     5281 tcataatctt gaagttgact tctttggcgg tgagccaaca atgaacttcg gtgttgtaaa
     5341 ggaagttgta gaatatggac gttctcttga agaaaaacat aacaaacatt tccgtttcac
     5401 tttgacaacc aatggtgtgc tgttaaatga cgagattatg gaatttgcca ataaagaaat
     5461 ggacaacgtt gttttaagtg tcgatggacg taaagaaatc catgattaca tgcgtcctac
     5521 aagaaatggt aagccaagct atgaccttat catgccgaag tttattcgtt ttgcagagtc
     5581 cagacatcag cagaaatact atgtaagagg aacatttacc aatagaaatc ttgatttctc
     5641 caaagatgtt cttcatcttg cagacttagg atttgaacag atttccatgg aaccagttgt
     5701 tggacagcca gaagagccat acgcaattca ggaaaaagac cttccacaga tttttgatga
     5761 gtatgacaga cttgcaaaag aaatgattaa gagagaaaaa gcaggaaaag gctttaattt
     5821 cttccacttt atgattgacc ttacaggtgg tccatgtgta gcaaaaagac tttccggctg
     5881 tggaagcgga acagagtatt tagcagtaac accgtgggga gatttatatc cttgccacca
     5941 gtttgtagga gaagagaaat tccttcttgg taacgttttt gatggaatca agcgtaccga
     6001 tatttgtgac gaattccgtt cctgcaacgt atacacaaag aaaaaatgta aagactgttt
     6061 tgcgagattc tactgtagcg gcggctgtcc tgcaaactct tataatttcc atggaacaat
     6121 tgatgattct tatgatttaa gttgcgatat ggagcgtaag agagtagaat gcgcaattat
     6181 gattaaggct gcattagcag atacagaagg cgaagaagaa tagatggaaa agtggtttat
     6241 cgcttcaaaa agagcagatt ttaataaaat tggtgagata tttcatatca gcccggtaac
     6301 ggcgcgtctg atgagaaata ggagcttaac aacagttagg gaaatgcagc gttatcttta
     6361 tggctctctg tctgatttat atgattctca tcttttgaaa gatgccgata agggagcgga
     6421 aatcataaaa gagaagatag aaacaggcaa aaagattcgg attatttcgg attatgatgt
     6481 agatggtgtt tcatcaaact atattttata tcagggatta aaacgctgtg gtgcggatgt
     6541 tgattataag attcctgacc gtgtggaaga cggttatgga attaatgaac atctgataga
     6601 aaaggcagca ggggacggaa ttgatacgat tatcacctgt gacaatggaa ttgcggcagc
     6661 agaacagatt gcttatggaa attctttagg actcaccctg attgtgacag atcatcatga
     6721 tattccgttt caaaggcaag aagatggaag catttcttat aatttgccgt cagccgctgc
     6781 cgttattaat ccgaagcaaa aagattgtcc gtatccattt gaaaatatat gcggagcggt
     6841 tgttgtctac aagtttattc aggtgcttta cgatttgttt ggaattgacc gtagagaaag
     6901 tgaagcattt cttgagattg cggcgatggc aacagtatgt gacgttatgc cattgtgtga
     6961 tgagaaccgt attatcgtaa aggaaggcct gcaacggata cagcatacga atattaccgg
     7021 gctgcaagct ttaattgagg caaatcatct tgaagaaaaa aagatatctt cttatcactt
     7081 tggatttatt ctcggtccgt gtattaatgc ttccggtcgt ttgacctctg caaaagatgc
     7141 gttagaactt cttctatgcg aagataaaga actttgcagg cagaaagcag aagcactcac
     7201 acagctaaat gcagagcgaa aagaaatgac agctaacggg gtaaaagctg caaaagaata
     7261 tctcgaaagc accggacatg gaaacgataa ggtacttgtt gtatatcttc caaactgtca
     7321 cgaaagtatc gccggaatta ttgccggaag aatgaaagaa cattaccata agccagtatt
     7381 tgtcatcaca agaacaaaag aaggattaaa aggctctggc cgttctatcg aagcctatca
     7441 tatgtataag gaaatgaaca aaatcaagga atgtttcgat aaattcggtg ggcacccgat
     7501 ggcagcagga ttttctatgc aggaagaccg cttagaagaa ttccgggaaa aattaaatgc
     7561 caacgcaacc cttaccgagg atgatttcgc agaaaaagtt cacattgatg tagccttgcc
     7621 gatatcttat ttatccgaaa gtctcatcaa tgaatttgaa ttactagaac catttggaaa
     7681 tgaaaacaca aaaccgctct ttgcacaaaa agacctttac ataaaaggaa tgcgggtact
     7741 cggaacaaca ggcagatgtt taaaactctt cctgtcggat gccaatggaa caagcataga
     7801 tgccatgtat tttggagaat ccgatggatt tttagaagaa ctcatctctt tttgtggaaa
     7861 agaagaggca cagagaattc aaaaaggcct gtcacatcat atatggatgg atgtgactta
     7921 ttatccacag gtaaatgaat ggcgagggca gaagaatatc caaatcgtca tccagaatta
     7981 tcgttttaaa aatttatgag ataaattttt tagtgcttct ttcgcatatt ttttcgtcta
     8041 tttagattcc caattaataa aaactatcct aatttgacaa ataaggcgag aatcaataga
     8101 ataatatgag gatgaaaaga gagatacatc aaaatcgcta tgaattaaga gatagataag
     8161 gagaaaatat ggaacaggag aaaaaacagc cagatgtcag attgatagga ttagatttag
     8221 atggaacaac gctcacttca gataaggtgt taactccaca tacaaaggaa gtacttgaga
     8281 aatgtcttgc ggaagggatt caggttttac cggcaacagg aagagtaaaa tcgggtattc
     8341 cagagtattt aacacagatt gaagggatga gatatgttat tttatccaat ggtgcaagtg
     8401 tattagattt aaaagaggat aaagttcttt atcagaattg tattccgtgg gagagagcat
     8461 tggagttatt cgatgtgtta gaaacatatg atacatttta tgatatttat gcattaggag
     8521 ctggctggtg tgaggctcgc ttttatgata atgtagaaaa ctatggaatt gagaaacata
     8581 tcgagaagct ggttcgtaca tcacgcaatc gtattgatga tttaagagag tggatgaaag
     8641 aaaataaagc tccagtggag aagataaata tgttctttgc aaaggaagaa gacagacaga
     8701 gagctttccg tgaacttgga aagatagaag atttggcggt tacctgttct cttggtaata
     8761 atcttgagat taatggggca acttgtaata aaggagatgc gatgctcaat cttggaaaaa
     8821 ttcttgatat tccgatagaa agtattatgg cgtgcggcga tggcaataac gattttgaga
     8881 tggttaagat ggctggtgtc ggtgttgcta tgaaaaacgg agaagagtct ttgaaagagg
     8941 ttgcagattt tgtgacaaag acaaatgatg aggaaggcgt agcatacgct atcgagcatt
     9001 tttgtaatgt gtaagtagaa ataaacgttt ttctgttgtt ttttacataa aaaatctgtt
     9061 ataattaatc ataagaagaa aaagcgcgaa gataaaagtc tgtgcttaat agttttatgc
     9121 ctgatttggg ggcagaaagg gtggacaaag tgaaaaaact tgaagattat gtcattaata
     9181 ttccagattt cccaaagccg ggaattattt tcagagatat tacctctatt ttacgtgatc
     9241 cggagggact gaaacttagc gtacatgaat tgatgcattg cttagaggga acagagtttg
     9301 acgtagttgt tggagcggaa tcccgtggat ttttatttgg tatgcctctt gcttacaata
     9361 aaagcaaggg atttgttcct gtccgtaaga aaggaaagct gccaagagag actgtaagca
     9421 aagaatatgc tttagagtat ggaacagcag agattgaaat ccataaagag gacattcgtc
     9481 caggacaaag aatcgtattt gtggatgacc ttttagcaac tggtggaaca gcaaaggctg
     9541 cgattgatct gatcgaagaa cttggtggcg ttgtcgtaaa ggttctgttt gttatggaac
     9601 ttgagggatt gcatggccgt gatgtattaa aaggctatga tgtagagtct gttattactt
     9661 atcctggaaa gtaattttga aggaaaagaa actgtgtgga tggaattttt tggaagcaca
     9721 gtttctcttt gtgtaaaaat tgttctgtag ttataaagtt gaatttctat ttgcaatttc
     9781 ttcctttaaa tcctgcattt tgctttacaa aaagaagaaa atggagtatt atgaaatata
     9841 cttaatttta cagaataggt ggaagaatag agtggaacat ttaaatttat tacagagaat
     9901 agagaagaag tcttccgagt tcagtaaagg acagagaaga ctggctcagt atattacaga
     9961 gaactatgat attgcggcat atcttaccgc ttcaaagctt ggaaagaaag caggagtcag
    10021 tgagtctaca gtggttcgtt ttgcttatca gcttgattac gagggatatc cagagctaca
    10081 gaaggcaatt caggttattg taaagacaaa ttcaaactcc attcagagaa tgtccctttc
    10141 ctcaaaaaga tatcaggaaa aaggtgtatt aaagagtatt ttgtatacag atgcagagcg
    10201 gcttcgcgat acgattcaga gcggtgtaga tgaggaagaa tttaacagat ccgttatgct
    10261 tatcaatgat gcaagaagat tatatatttt aggtgcgaga agtgcagctt atcttgccgg
    10321 tctgatggga tattatttta agatgatgtt tgacaatgta attatcgtag atgccaacag
    10381 cacgtccgag acattagagc agatttacga tatcagtgat aaggatgtta tgatgggaat
    10441 tacttttcca agatattcaa agagaaccat ctgtgcgctt cagtatgcga agaatcatgg
    10501 agcgaagaca atcgcactta ccgacaatat gcagtctcca attgtagagt atgcagattg
    10561 taaattaatt gcaaagagtg atgtaatgac aatcgtggat tctttagtat gtccgttaag
    10621 tgtggtgaat gcgatggtta cagcgattgc attacttcgt aaggatgatg tagagaagcg
    10681 tcttatggca cttgaagaac tctggaacga gtatgatgtt tataacagga gtttactata
    10741 atgaacaaag taattattgt aggcggaggg gcagccggta tgatggctgc catttctgcg
    10801 tctaaagagg ggaaaaaggt ctgcattctt gaaaagaacg aaaaacttgg caagaagctt
    10861 tttattacgg ggaaaggcag atgcaatatt acaaatgcct gcccggcaga cgaatttctt
    10921 acccatgtgg taacaaatcc aagattttta tacagtacat tttcgcagtt taataatgag
    10981 gatatgatgg actatttaga agaaatcggt cttccgataa agacagagag aggacagaga
    11041 gtatttccac agtccgaccg gtcttcggat gtaattgatg cattaaagaa acagtgtaaa
    11101 aaaggcgggg tacagattta ctatcacaca gaagtaaaag aactactttt tgatgaagaa
    11161 aaagaaaact gtgtcggtgt acttttgtct gacggaaaga aaatgatggg agattctgtt
    11221 atccttgcct gcggcggctt ttcctacgct tctaccggtt ccaatggatc gggatacaca
    11281 cttgcaaagc aagcaggaca taagattaag tctatagaac catctttagt tccatttgag
    11341 atgaaagaaa tgtggtgcaa agatttgatg ggacttactt taaagaatat aggggtgcgt
    11401 atcaaagcaa agaaaaagac agtttatgaa ggatttggag aatttctctt tacgcatttt
    11461 ggagtgagtg gtccgcttgt tcttacggca agtacctgtc ttggcaaata tcagaaagag
    11521 ttagaggcag gcgaattaaa actgattctt gatttaaaag cctctcttac cccggaacag
    11581 ttagataaac ggtttttaag agaatttgac acttatcgta ataaaaatat ttctaatgtg
    11641 atggaacgtc ttcttccaaa gaaaatgatt cctgttttct tagaagaagc acaaattccg
    11701 gaagataaaa agataagaga catcagcaaa aaagaaagaa ggcatatgat tgagctgatg
    11761 aagaatttcg agatgcatat cacaggagtc cgtggcttta atgaggcaat cgtcacgaga
    11821 ggcggagtaa atgtaaaaga aattaatccg tctacaatgg agtctaaaaa agtaaaacat
    11881 ttattttttg ccggagaaat gatggattta gatgctgtca caggcggcta taacctgcag
    11941 attgcatgga caacaggcta cgtagcaggc aaaaatgcgt aaagaaaacg taaaatttaa
    12001 aaaattataa aaaaatagtt ttttttttcg gaaaaatatg ttacactaat caagtgtagg
    12061 taaaagtgaa atcactgtat acgcagtcag gtttcaaaag aatgggagga aatgtccatg
    12121 tatagtatag caattgatgg gccagcagga gctggaaaga gcacgattgc aaaggcaatc
    12181 gcagaagata taggttttat atatgtagat accggagcaa tgtaccgggc aatcgcttta
    12241 tattttttgc gtaaaggtat tgatggacat gacaggaagc tcgttgcggc agaatgtcct
    12301 aacattcatg taactttaga atatgacgag gaagggaaac agcaggttat cttaaatggt
    12361 gagaatgtta ccggatatat ccgtaaggaa gaagtcggta agatggcatc agtgacatcc
    12421 gctgttccag aagtaagagc tgcactgctt gatctgcagc gcgatatggc gaagacttcg
    12481 gatatcctca tggatggaag agacattgga acgaatgtcc tgccagatgc atctcttaag
    12541 atttatctga cggcctctgc tgatgtaaga gcgaagagac gttatgacga attgaaagag
    12601 aaaggtgcag actgtgatat cgagcagatt aagaccgata ttatagcaag agataagcag
    12661 gatatggaga gagagatcgc tccattatgc caggcagaag atgccatact ggtagattct
    12721 tctgatatgt caattccgca ggtgattgat acgattatct ccgaatttaa aaaaataaaa
    12781 taatattgcc ggagtaaatg atgaaaatta acatagcaaa atctgctggc ttttgttttg
    12841 gagtaaagag agctgtagat accgtgtata aagaatcttc gaagaagaat gtttatacat
    12901 tcgggccgat cattcacaat gatgaagttg tcgcagatct ggaaagacaa ggggttcatg
    12961 tcatcaatga cagtgaagat ttcaagtctc tttcagaggg aacgattatt attcgttctc
    13021 acggcgtgtc aaaagcaatt tatgatgaga tccttaatgc gggtcttgat ttagtggatg
    13081 cgacctgccc ttttgtgaga aagattcata aaatcgtcga gcgggagagt ggggatggca
    13141 gagtaatcat tattataggc aataaccatc atcctgaagt agaagggatt atgggttggt
    13201 gccatacgca tccgattgta attgagaatc gagagcaggc agaaggaatt gagttagatg
    13261 ctgatacgaa gatatctatc gtgtcccaga cgacatttaa ctacaataag tttcaagatt
    13321 tagttgaaat tatctcagaa aagggttatg atataaatgt ttttaacacg atttgtaatg
    13381 cgactgagga gcgtcagacg gaagtcaggg aactggcgaa gaagtccgat gcgatgatag
    13441 taatcggtgg cagacacagt tcgaatactc aaaagctttt tgagataagt aaaaaagaat
    13501 gtagtaatac tttttatata caaacaaaaa atgatttgaa tatggaggat ttttctaata
    13561 tcgggatgct cggtattact gcaggggctt caaccccaaa taatattatc aaggaggttc
    13621 atgaaagcat ggcagaaatg agttttgacc agatgctgga agaaagtttt aagacaatca
    13681 gaaatggaga ggtagttcag ggtactatta tcgatgtaaa agaggatgaa atcatcttaa
    13741 atattggata taaagccgac ggtatcattt caagaaacga atattccaac gaccagaatt
    13801 tagacttaac aacagttgct aaagttggtg acgagatgga agctaaagtt cttaaagtga
    13861 atgatggcga aggacaggtt ctcttaacat ataagagact taaagcagaa aaaggtaata
    13921 agagattaga ggaagcattt aacaaccacg aagtattaaa agctcctgta gctaaagttc
    13981 ttgacggtgg tttaagtgtt gtagtggaag aaacaagagt attcatccct gcaagccttg
    14041 tatccgatac ttacgagaag aacttaaaga aatatgacgg acaggaaatc gagttcgtta
    14101 tcacagagtt caaccctcgc aagagaagaa tcatcggtga ccgtaagcag cttttagtag
    14161 cagagaagaa agcaaaacag gaagcactgt ttgcaaaaat cgaagctggt atgactgtag
    14221 aaggaactgt aaagaacgta acagatttcg gtgcattcat cgatttaggt ggagcagacg
    14281 gacttcttca catctccgaa atgagctggg gacgtgttga gaatcctaag aaagttttca
    14341 cagtaggtga aaaattaaac gttcttatca aagatatcca gggagaaaag attgcattat
    14401 ccttaaaatt ccctgaaaca aacccatggc ttcacgctga cgaaaaatac gcagtaggta
    14461 acgaagtaac tggtaaagtt gctcgtatga cagacttcgg tgcattcgtt gaattagagc
    14521 caggcgtaga tgcattactt catgtttctc agattgctaa agagcacatc gagaaaccat
    14581 ctgatgtatt aaaagtaggt caggaagtta cagctaaagt tgtagatttc aagaaagatg
    14641 atcgtaagat cagcttaagc atcaaagctt tagataacga ataatattta gcggaatttg
    14701 gctaggtaga cgaaaataaa aaagacttat aatagcacct gtgactttag tcgcggcatg
    14761 ttgaatgttc gcttaagggc tcgcatccaa cacttgctcc gaggtcacat ctgctattat
    14821 aagtcttttt cattttctga ctttggcgca aattccgctg tggaggattt gaggattctc
    14881 cagaagagga tgggagtggg tggaaaattt tcttcgttat agttaatgtt tcactggcat
    14941 tttatataat tttgctataa ataaaacttc ttataagtat aatatatatt atgtgaaaat
    15001 ttatat
//
