LOCUS       gnlProkkaFAEBFOCD_21   11560 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FAEBFOCD_21.
ACCESSION   gnlProkkaFAEBFOCD_21
VERSION     gnlProkkaFAEBFOCD_21
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 17:43:52
            Original ID  :: gnl|Prokka|FAEBFOCD_21
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11560
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11560
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[160:1560]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      161..1560
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..11560
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11560
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             161..448
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.9e-08,
                     bitscore: 26.1, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1e-13, bitscore: 43.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDLIRYYKVEEPFERHEENYLVLSEKKGEIVTLNETSFFIWDNC
                     DRKNINEIVNMLEEVCENGAELDICLIKNDCRMAIDKMVEKGLILERNVK"
     CDS             445..1560
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_2"
                     /sec_met_domain="PF04055 (E-value: 8.6e-21, bitscore: 66.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.1e-13, bitscore: 43.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.7e-11, bitscore:
                     36.2, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.3e-10, bitscore: 32.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKDEHNIDFNLFGDYELAGCYIEITSRCNLRCKHCYNESGELRK
                     ELDLQAFLNAYDGIPDTEECSITLSGGEPLLHPQVWEFIDRIQKRKSTKNLIITNATLI
                     TEDIAKRLVKSGINVQISLNGSCPTTHDKLCGKGNFEKTLCGMDKLLSLGYAERVVVRC
                     MASKYNMDDIVNTIKFVTDRGIKTINIATLSIMGRAKEALNEMYLSIQEKEKLIEKLNK
                     DEEIKRIKEKGFIISLPEGYSGGCPLIYPNEKKIPLSPRIDSKGNVFLCQMFGDEKYAV
                     GNINEQSIWEIIEGEKFSQLIWFLRFGIQYLHKCTNCIWRMSCGKGCVAMILNNGSIQE
                     TDGDCHFRKKEFFDKYIQRMSKNDIKAEPLT"
     CDS             1922..3649
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 145.8; E-value:
                     2.7e-44)"
                     /gene_kind="transport"
                     /locus_tag="ctg21_3"
                     /transl_table=11
                     /translation="MKKAIGLVFKFCISNFRIILIWGTILLGINMLQPLEIKIVNALIK
                     CLHEECSFIFLVGLFLLFFFITIFKELQSSLNEVLHIFFQNRISKYFFSLFVNNIRHRG
                     IIDYDNSEFLLKIKRSKISIDSKIYQIIANLLQIIAGIVSLFFLSAMIVDVDKLFLVFF
                     IIIFALQLVYSKKITNANLKLYRVQDNDQRKHTYFNGLMRSRESIKEIRISNCMEWIEG
                     KRKQVYSKIEYEHLRFIKKWNLINAIWTILGTGMETLIFLYLVYGYSIEIFSVEEVVLI
                     IQSQEVLILYLISMINTFSQIRQDMEYLKDFAYCCNQKKAKVVDNIELSEKKLIKIQNI
                     FFAYSPGEQILKDCSIEINKGEKIMVVGKNGCGKTTLVKIILGLYKPTKGNILFNKKKG
                     NVVFQDYVRYKFSLRENIGLGNVADIDDEKYIKELLDELKLEYLYQNEKELDVMLGKEF
                     DDDSIDLSGGEWQKIAIGRAMFNKDSDLIILDEPTAALDPIAELQEFNKICEYFSNKTV
                     VLISHRIGLAKSVDKVVYMDNGRICEVGTHVELMKNKGNYYNFYNSQAKWYCMERGDA"
     CDS             3734..5470
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 183.4; E-value:
                     9.1e-56)"
                     /gene_kind="transport"
                     /locus_tag="ctg21_4"
                     /transl_table=11
                     /translation="MNISKYLNNMKIIRGVIDNICKRCLIINVIISFMGAAFVSYKTWV
                     LKEVIDEVSISINKTVIYICVYFALNICIDIFEGVEGYIQTKVSYRINEELNVKINSKI
                     SKIRLNIFDDERFYDLLERLNDNIGVGALEFIKSSISISSGLISITIYVVILYSVQWYF
                     PFVFILASIPYYFVALKESKELYSQEKELNKLGRLLSYTENIIFDRNVIKEIHIFQLYE
                     FIVKKANLLRDKIVKKKVRLLYKQGKRKLGINVLKNLSLVGCLAITYINIKYNNGQIGD
                     FMAIYLAIKNLLTEIVSFVSEIKTLNTYDLYLEDLNFFYSYPEEKCLSHKIENKEINFK
                     NVYFKYDDTKDYVLENINISIPFGKKIALVGKNGSGKTTFINLLLGIYDPSLGSITIGN
                     ENLINIKEEFYEQISVVLQNYNKYQTSVLENIGLGVKKKCEIQNIVKNKIFNFIEKLPL
                     GINTKLGQLEKDGYELSGGEWQRLALARALVRNKSILIMDEPTASLDPVTESEIYEQFE
                     EFTKGKTAILVTHRLSAAKLCDVICYFEKGRIIEIGSHEELCEKGGKYYNMYKKQEDLY
                     KN"
     CDS             5778..6104
                     /locus_tag="ctg21_5"
                     /transl_table=11
                     /translation="MLFAEAKCKLLQSRPWGLPKKTPVKSTDVANQNPHLPHLLILQLP
                     TKEGCNFLYFTFAINRSSPLSVSDRINSTMRSIEVAQKSWIALYDKYADGKLERDFFER
                     EEAV"
     CDS             6043..6147
                     /locus_tag="ctg21_6"
                     /transl_table=11
                     /translation="MINMLMENWKEIFLNEKKQYDADMEKLEEELAAL"
     CDS             6208..6312
                     /locus_tag="ctg21_7"
                     /transl_table=11
                     /translation="MAFLEEDMKDKLIEKVVVYPGNRIEIVWKFEGHF"
     CDS             6530..6871
                     /locus_tag="ctg21_8"
                     /transl_table=11
                     /translation="MNQSVSALGSVVRATRKSKNLSQEALAEKLGVCKRTIIDIEKNTG
                     NPKFELLCMLVRELDLPLYEVFYPEMEDCSEAKNVLMKELSDCSEYEMKIILSVVKSLR
                     CTLKNEKAI"
     CDS             7647..9638
                     /locus_tag="ctg21_9"
                     /transl_table=11
                     /translation="MAKKAEELLCYIFEEILPEHGMSLRENQKELSLEMLRALIENKLA
                     LCEAEVGTGKTHAYILALTVYNLYAKTKASAVISTSTIALQKALTEEYIPQISNILLEH
                     KIIEKPLTFVIRKGKKHYVCDTRLRTYESSIKNLDRELDQKLLIELKRLTGENENLLDL
                     DNAILTPYVKGRINVLQCRESCPYAVLCRFMNFKKKCMLSGIDFQITNHNFILADLIGR
                     KQGRKPLFPAYHAIVLDESHKLVDAARQMYSTFLEEQELERLLALANGNRVMGVRSMER
                     LEQLSSHILKNSELLFERLGYGLSGNHTREGSRESFTVGLIEQIYIKNIIYGLEQMALL
                     CKEDGGNRTRNVQRGCQNLIDKYNIFLNSNYFICWMEKRENGRLAMCVIPMELERILYE
                     DIWNRAIPSILTSGTMSVRGDFTHFRRNTGINFAPDRRIMETSKESPFDYKNHGMLYIP
                     ERMPFPNIRDGKYMEILMEEIKKIINATHGHTLILFTSYWLMERVFYGLKEEISGYPLF
                     MMGKGRLDVISNFRKSGNGVLFASDSAGEGIDLAGDILSSLIVVKLPFPVPDPVMEYQS
                     RQYDDFELYKQDIIIPAMLIKLRQWMGRGIRRESDSAVFTILDSRASLCGKYREEILNA
                     LPSMPVTDRLVDVADFIIRKKADSYFEE"
     CDS             9652..9774
                     /locus_tag="ctg21_10"
                     /transl_table=11
                     /translation="MKIVWIVAGILIGILLLLFLLACIGIVGAGLEMETWERDR"
     CDS             9789..10061
                     /locus_tag="ctg21_11"
                     /transl_table=11
                     /translation="MFEYTQEQIEEMKQVDIRTVSRDELRDICEVKVNHRLKGEERIKD
                     FLEQVGNPYCFNCGDYIVKVGFTDTSATLTGCLKEYVGRVSKANF"
ORIGIN
        1 atttgtttat cagtatcccc aaaactttta tcgggaaaaa ttacatttaa actaggaaaa
       61 attacattag agcgtaatgg gagaatatat gtattaagat gtaaagcaga aagcgattgt
      121 tgcataatgg ttgcagattc tttcagagga ggtatggcaa atggaggatt taataagata
      181 ttataaagtt gaagaaccat ttgaaagaca tgaagaaaat tatttggttt taagtgaaaa
      241 aaaaggagaa attgttacat taaatgaaac ttcttttttt atttgggata attgtgatag
      301 aaaaaatata aatgaaatcg ttaatatgct tgaggaagtt tgcgaaaatg gggcagagtt
      361 agatatatgt ttaataaaaa atgactgtcg aatggcaatt gataaaatgg tggaaaaagg
      421 cttgatttta gaaaggaatg taaaatgaaa aaggatgaac ataatattga ttttaattta
      481 tttggtgatt atgaattggc agggtgttat atcgagatta cgtcacggtg taatttgagg
      541 tgtaaacatt gctataatga atcaggcgag ttacgcaaag aattggattt acaggcattt
      601 ttaaatgcat atgatggcat tccggataca gaggaatgca gcataacctt atctggcgga
      661 gaacctcttt tgcatccgca agtttgggag tttatagata gaatacaaaa aagaaaaagt
      721 acaaagaatt tgattattac caatgccacg ttaataactg aagatatagc caaaaggtta
      781 gtgaagtctg gaattaatgt gcaaattagc ttaaatggtt cttgcccaac gacacatgat
      841 aaattgtgtg gaaaaggaaa tttcgagaaa acgctatgtg gtatggataa gttgttgagt
      901 ttaggttatg cggaacgagt cgttgttaga tgcatggcat ctaaatacaa tatggatgat
      961 attgtcaata ctataaaatt tgtgacggat cgtgggataa aaactataaa tattgctact
     1021 ttatctatca tgggacgagc aaaagaagca ttaaatgaaa tgtacttaag cattcaagaa
     1081 aaggagaagt taattgaaaa attaaataag gatgaggaaa ttaaacggat aaaggaaaaa
     1141 gggtttatta tttctttgcc ggaaggatat tcgggtggct gtccgctaat atatcctaat
     1201 gagaaaaaaa taccattgtc accgaggatt gattcaaaag ggaatgtttt tttatgccaa
     1261 atgtttggtg atgaaaagta tgctgttggt aacattaatg agcaatctat ttgggaaata
     1321 attgagggag aaaagttttc acaattaata tggtttttac gttttggaat acagtatttg
     1381 cataaatgta ccaattgcat ttggcgcatg tcttgcggaa aggggtgcgt tgcgatgata
     1441 ctcaataatg gctctattca agaaacagat ggagactgtc attttagaaa aaaggaattt
     1501 ttcgataaat atattcaaag aatgtctaaa aatgatatta aagctgaacc cttgacataa
     1561 atattcatat tgaagaaagg agaaaaagat atgaagtatg cacagcctgt agtaaatggt
     1621 aatgccgtat cacctcgtag tgtaagttgt aacgctccta ttaagtacac ctgctcatca
     1681 gttttcaagt gcagtggaag ctttgtctgc aatgacaatt actttacctg caagaagact
     1741 tggaatgtat aagcagcatt aaattaatga tgcatgacat agaacttgca tcatacataa
     1801 aatctaggaa acccgtggta acggctttaa tataaaaaat aaatatgaat attgggggac
     1861 ctagatttga aagctttgtt atgtaacatg acaaagcttt cgccttttta ggagggaaat
     1921 tatgaagaaa gcaataggat tagtgtttaa attttgcata agtaatttta gaataatact
     1981 tatctggggg acaatattat tgggaataaa tatgctacaa cctttagaaa taaaaattgt
     2041 aaatgctttg attaaatgtc tgcatgaaga atgttccttt atttttttgg tgggtttatt
     2101 tttgcttttc ttttttataa caatattcaa agaattacaa agcagtttaa atgaagtttt
     2161 gcatattttt tttcaaaata ggatatcaaa atattttttt tcattgtttg ttaataatat
     2221 aagacacaga ggaataattg attacgataa ttcggaattt ttgctaaaaa tcaaaagaag
     2281 taaaatatca atagatagta aaatttatca gattatagcg aatttattac agattatagc
     2341 aggtatagtt tctttgtttt ttctttcggc tatgattgtg gatgtagata agctgttttt
     2401 agttttcttt ataattattt ttgctttaca attagtctat tctaagaaaa taactaacgc
     2461 taacctaaaa ctgtatagag tacaagataa tgatcaaaga aaacatacat atttcaatgg
     2521 tttgatgcgg agtagggaaa gcataaaaga gattaggata agcaattgca tggagtggat
     2581 agaaggaaag agaaaacaag tttatagtaa aatagaatat gaacatttaa ggtttataaa
     2641 aaaatggaat ttaataaatg ctatatggac tattttagga acaggaatgg agactttaat
     2701 atttttgtat ttagtatatg gatattctat tgaaattttt tctgttgaag aagtggtttt
     2761 aattattcag tctcaagagg tgttaatttt atacttaata tctatgatca atacattttc
     2821 ccaaattagg caggatatgg aatatctaaa agattttgct tattgttgta atcagaaaaa
     2881 agcaaaggtt gtggacaaca tagaattgag tgaaaaaaaa ttaattaaaa ttcaaaatat
     2941 tttttttgct tatagtcctg gagagcaaat attaaaagat tgtagtattg agataaataa
     3001 aggtgaaaaa attatggtgg ttggcaaaaa tggatgtgga aaaactactt tggtaaaaat
     3061 aattttagga ctttataaac ctactaaggg aaatattttg ttcaataaaa aaaagggcaa
     3121 tgttgttttt caagattatg taaggtataa attttctttg cgtgaaaaca tagggttggg
     3181 aaatgttgca gatatagatg atgaaaaata tattaaagaa ttattagatg aactgaaact
     3241 ggagtattta tatcaaaacg aaaaagaatt agatgtgatg ttggggaaag agtttgatga
     3301 tgattcaata gacttgtcag gtggagaatg gcaaaaaata gcaatcggta gggcaatgtt
     3361 taataaagat agtgatttga ttattttaga tgaacccaca gcagcattag atcctattgc
     3421 tgaattacag gaatttaata aaatatgtga gtatttttcg aataaaacgg ttgttttaat
     3481 atcacatagg attggactgg cgaaatctgt agataaagta gtatatatgg ataacggtag
     3541 gatatgtgaa gttggaacac acgtagagtt gatgaaaaat aaaggaaatt attataactt
     3601 ctataattct caggcaaagt ggtattgtat ggaaagaggc gatgcttaat agcgttttat
     3661 tacaccatag tcaagtaaga gcgaatagta ttggtaacat acgtatggaa agggtacatg
     3721 gaaagttaaa gagatgaata ttagtaagta tttaaataat atgaaaatta ttagaggagt
     3781 tattgataat atttgtaaaa ggtgtttaat aataaatgtc ataatatcat ttatgggagc
     3841 agcttttgtt tcatacaaaa catgggtttt aaaagaagta atagatgaag tctcaattag
     3901 tattaataaa acagtaatat atatatgtgt atattttgct ttgaatatat gcatagatat
     3961 atttgagggt gttgagggct atattcaaac aaaggtaagc tatcgcatta atgaggaatt
     4021 gaatgtaaaa ataaatagta aaatttctaa aattagatta aacatatttg atgatgaaag
     4081 attctatgac ttattggaac gtctgaacga taatattgga gttggcgcat tggaatttat
     4141 taagtcctct attagtattt ccagtgggtt aatttcaatt acgatatatg tagtaatttt
     4201 atattctgta caatggtatt ttccgtttgt gtttatattg gcaagcatac catattattt
     4261 tgttgcatta aaagagagca aagaacttta tagtcaagaa aaggagttaa ataaactagg
     4321 gagattactt agttatacgg aaaatattat atttgatcgt aacgtcataa aagaaattca
     4381 tatatttcag ttgtacgaat ttattgtaaa aaaagcaaat ttgttaagag ataaaattgt
     4441 aaaaaagaaa gtgagacttt tatataagca gggaaaaaga aaactaggta ttaatgtatt
     4501 gaaaaatttg tcattggtag ggtgtttggc tataacgtat ataaatataa aatataataa
     4561 tggtcagatt ggggacttta tggcaatata cttggctata aagaacctac tgacggaaat
     4621 tgtctcattt gtatcagaaa taaaaacctt aaatacatat gacctatatt tagaagatct
     4681 caactttttc tattcatatc cagaggaaaa atgcttgagt cataagatag aaaataaaga
     4741 aattaatttt aaaaatgttt actttaaata tgatgatacg aaggattatg tgttggaaaa
     4801 tataaatatt tcaataccat ttggaaaaaa aatagctttg gtgggaaaaa acggtagtgg
     4861 aaaaacaaca tttataaatt tattattggg aatatacgat ccatctttgg gtagcattac
     4921 tattggtaat gaaaatttga taaatattaa agaagaattt tatgaacaaa taagcgttgt
     4981 gttacaaaat tataataaat atcaaacaag tgttttggaa aatattggtt taggagtaaa
     5041 aaaaaaatgt gagatacaaa acatagtcaa aaataaaata tttaacttta ttgaaaaatt
     5101 accactagga ataaatacaa agctaggtca gttggagaaa gatgggtatg aattatcagg
     5161 tggcgaatgg cagaggttgg cattagctag ggcattggtg cgaaataaaa gtattcttat
     5221 tatggatgaa ccgactgcta gtttggatcc ggttacagaa tcagagattt atgagcaatt
     5281 tgaagaattt acaaaaggga agacagctat attggtaaca catagattga gtgctgcaaa
     5341 attatgtgat gttatctgct attttgagaa aggcaggatt atagaaatag gaagccatga
     5401 agaattatgt gaaaaaggag gaaaatatta taatatgtat aaaaaacaag aagatttata
     5461 taaaaattaa aggatttatg aattgaagta attatcgcat tatgtgggta aatcagaacg
     5521 gtagtgtcag caatgagagt catttgggat gctacaacga aaggatactg ttatagcggt
     5581 atataacaag gacagggaag aatttctact taatttcttc cctgtccttg ttgctatatt
     5641 tgaataatgt aaatagtaaa ctgatagttt taatttgcta tttgcaagga ggcatctgtg
     5701 ccttgtacgg ctatcaaaag tcaaaagaag ataagcacaa gctagtcata gaactggaat
     5761 aagcggcggt tgttagggtg ctttttgcag aggcaaaatg taagttgttg caaagcagac
     5821 cttgggggct ccctaaaaaa actcctgtaa aatcaacgga tgtggcaaat caaaacccac
     5881 atttacccca tctattgatt ctgcaattac ctacaaaaga gggctgcaac tttctgtatt
     5941 ttacttttgc aataaacaga agttcccctt tatccgttag tgacaggatt aattctacaa
     6001 tgaggtcgat tgaggtggca caaaaaagct ggattgcatt gtatgataaa tatgctgatg
     6061 gaaaactgga aagagatttt tttgaacgag aagaagcagt atgacgctga tatggagaaa
     6121 ctggaagaag aacttgcggc actctagcag gtacaggaag aagaggaaag cgagcaggaa
     6181 agctctggga ggaaagcaga ccaggctatg gcatttctgg aagaggatat gaaagacaaa
     6241 ctgatagaaa aggtcgttgt ctatccgggt aacaggattg agatagtctg gaagtttgag
     6301 ggacattttt agaaaattaa atacggcata gggatttccg gtctgtatag aagaggattg
     6361 cttttagtac agaccagatt ttttatataa attgatatgg tttactcgat aaatctggtc
     6421 tgttatattc acttgtcaaa atagtgagca aaagctcata ttttggtgaa ctgcggttag
     6481 attgttgact ctgaaagtga gttttataat atagtagagg tgaattaaaa tgaaccagtc
     6541 agtaagtgca ttaggaagtg tcgttcgtgc gacaaggaaa agtaaaaatt tatctcaaga
     6601 ggcattagcc gagaaacttg gcgtctgtaa aaggacgatt atagatatag agaagaatac
     6661 cgggaatccg aagtttgagt tactgtgtat gctggtaagg gagctggatc tgccactgta
     6721 tgaggtgttt tatccagaga tggaagattg ttcagaagcg aagaatgtgc ttatgaaaga
     6781 gctgagcgat tgctcagagt atgaaatgaa aattattttg tcggtggtaa agagtttgcg
     6841 atgtacatta aaaaatgaga aagcaatttg atttgacatt tattataaaa attagttgtt
     6901 tgctgctaat aaaaggtacg aataaactga aaaatggata cgctttagtt gtggattaat
     6961 tataaaaagc gtaatcccca tattagtgac tagaataaac ggaattatgt atttttaaaa
     7021 tataaattta ttatgagcag aaataaggtg attatcaata tgacaaaggt gtgagtatta
     7081 caattcattt tctgataaat tattataaaa aaataaaata aataaaaata tttcggcaga
     7141 ccccttcact taacggataa gtaagtgaag gggtcttatt ttgtttataa atacagcctt
     7201 cttcgctgta ctttgacaat ttcatactcg ttcatcaggc acagcagtaa cagatcggat
     7261 caccgataag cacgcagtca gaatacgcca ggcggaatta ttcaattatt ccaagcgaat
     7321 catatccgtg actgtacagc ccatggcagg gcgaaaatgc gatgacaact gttacagaca
     7381 atgatacttc catgaaagtg gcccacgagg agaggggaga atgcacaccc acgtttgaga
     7441 aagaatgtgg ggcggcttct atgatgcctg ccagccaagc aggatacctg atggatttta
     7501 aagagaattt attctcaata taaagcagta gaaactatgg gctggaggat cattattttg
     7561 taaatcaaaa ctcagacgac atccttccag cccatccttg tactgcttta gagcagtaaa
     7621 tgaatttgaa cataggagac gaaaagatgg cgaagaaagc agaagaatta ttgtgttaca
     7681 tttttgaaga aatattaccg gaacatggca tgagcttacg agaaaatcag aaagaattgt
     7741 cattggaaat gctccgggca ttgatagaga ataaacttgc cctgtgtgag gcagaggtgg
     7801 gaacaggaaa gactcacgct tatatcctgg cactgacggt ctataactta tatgcgaaaa
     7861 caaaggcatc ggcagtcata tccacttcga cgatcgcttt gcagaaggca ttgacagaag
     7921 aatacatacc acagatttct aacatcctat tggaacataa gattatagaa aaaccattga
     7981 cctttgtgat tcgcaaagga aaaaagcatt atgtctgtga tacaagatta aggacctatg
     8041 aatcatccat taaaaatctg gacagagagc tggatcagaa gttacttatt gaattaaaac
     8101 gactgacagg cgaaaatgaa aatttattgg atttggataa cgcaattctg acaccttatg
     8161 taaaaggaag aattaacgta ttgcagtgta gagaatcctg tccatatgca gtgttgtgcc
     8221 gctttatgaa ttttaagaag aaatgtatgt taagcggcat agatttccag attacaaatc
     8281 ataacttcat attggcagat ctgataggca gaaagcaggg aagaaaacca ctgtttcctg
     8341 cctatcatgc aatcgtgctg gatgaatcac ataagctggt ggatgcagcg agacagatgt
     8401 acagcacatt tttagaagaa caggaactgg aaagactgct ggcacttgcc aatgggaatc
     8461 gtgtcatggg agtacggagc atggaacgtc tggagcagtt aagcagtcat attttaaaga
     8521 atagcgaact gctctttgaa agacttggat atggcctttc aggtaaccat accagagagg
     8581 ggagcagaga aagttttacg gttggcttga tagagcagat ttatattaag aacatcattt
     8641 atggattaga acaaatggca ctactttgca aagaagatgg tggaaatcgc accagaaatg
     8701 tacagcgagg atgtcagaac ctaatagata aatataacat atttctgaac agcaattatt
     8761 ttatctgctg gatggagaaa agagaaaatg gcagacttgc catgtgtgta atacctatgg
     8821 aattggaacg tattttatat gaagatatct ggaaccgggc aattccttct atattaacat
     8881 ccggtacaat gtcagtccgt ggagatttta cacattttag aagaaataca ggaattaact
     8941 ttgcaccaga tagaagaatc atggaaacca gtaaggaatc gccatttgat tacaagaatc
     9001 atggcatgtt atacatacca gaacgtatgc cgtttccaaa tatccgggat ggaaaataca
     9061 tggaaatctt aatggaagag ataaagaaga ttataaatgc tacgcatgga cacaccctga
     9121 tcttgtttac ttcctattgg ctgatggaga gagtgtttta tggattgaaa gaagaaatca
     9181 gtgggtatcc attatttatg atgggaaaag gcaggctgga tgtaatcagt aatttccgaa
     9241 aaagtggaaa tggtgtactt ttcgcaagtg acagtgcagg agaaggaatt gatctggcag
     9301 gagatattct ttccagctta attgttgtca aactgccatt tccggtacct gatccagtta
     9361 tggagtatca gagcagacag tatgatgatt ttgaactcta taagcaggac atcattattc
     9421 cggcaatgct gattaagctt cgtcaatgga tgggaagagg aatccggaga gaaagtgaca
     9481 gtgcagtatt cacaatttta gacagcagag catctctttg tggaaaatac cgtgaagaaa
     9541 tattgaacgc attaccatct atgccggtaa cggacaggct ggtggatgtg gcagacttta
     9601 ttataaggaa gaaagcggat agttattttg aggaataggg gtagtaatta tatgaagata
     9661 gtatggatcg tggcaggaat tctaatcgga atcctgctgt tgttatttct gcttgcctgt
     9721 atcggaattg tgggtgcagg actggagatg gaaacatggg aaagagatag atagagggga
     9781 aatataaaat gtttgaatat acacaggaac agattgaaga aatgaagcaa gtggatatac
     9841 gaacagtaag ccgcgatgaa ctaagagata tttgtgaagt aaaagtaaac cacagattaa
     9901 aaggtgaaga acgaataaaa gatttcttag agcaggtagg aaatccctat tgctttaatt
     9961 gtggtgacta tattgtaaaa gttggtttca ctgatacatc tgcaacatta actggatgtt
    10021 tgaaagaata tgtgggaaga gtttctaagg ccaattttta aatttggccg cttgaaatcg
    10081 tccaagtcat gtgttagact tagaatcaag taggacaaat ctataatatc acggaaatac
    10141 tggattcaac agtctgacac tattgaattt caggagtgtg tatattatgg atttttttag
    10201 ttcagaaatc atatttattg tcgcagtata tctgcggcta tcgaaagagg atggggatct
    10261 tgatactgct ggtaagagtg aaagtaacag tatccagaac caaaaagcgt taattctaaa
    10321 tttcctcaaa aaacttccca atgtaaaaat ttatgatatt tatgtagatg atggatatac
    10381 cggaaccaat tttgacagac cggatttcaa acgtatgaaa cgagattttc tggaaggccg
    10441 tgtcaatatg gtcgtggtaa aggatctgag tcgttttggc agggactatg tagaagcagg
    10501 aaactatgtc cgcaatattt tccgtaatct taatattcgt tttgtatctg ttttagacca
    10561 ctttgacagt cttacagcaa cttctacaga ttacaattta ctattgccag taaagaattt
    10621 tgtgaacgat cagtattcca gtgatatttc caccaaagta agaggaaatc agggagccat
    10681 gcgtgaggct ggtaaataca ttggtcctta tgttggctat ggttttctga aatctccgca
    10741 ggacaagcac atcatcatag tagatgagta tgcatgggaa atcattatgc ggatggtgga
    10801 ttggaaatat gctggtttca gcaaccaaag aatagcggac cagctgaatg ccaccggggt
    10861 attgtctccg gcagaataca aacgaacact tggctgtaat tataaaagcg gttttcagac
    10921 gaagaataaa gcaaaatgga catcggttgc tgtaaagagg gtgctgagta atcccatgaa
    10981 taagggaatc atgattcagg gaaaacgtaa gcggattaat tataaagtgc gtaaggtcat
    11041 agagaaaccg caagaacagt ggaatatcaa gcataatgcg gttgtaacac caatgccatt
    11101 gctttgttat gataatgtac agcgcctgtt ggagcaggat atcagagtag caccagggca
    11161 ggaaaatgtg tacctttttg ccggcatggt ctattgtgct gactgtggac gaagcatgac
    11221 aaggcgaaaa acaaatgaga atatatttta catctgcact acatataatc gtggggatgg
    11281 atgcagccgt cacagcattc caaatgaaaa attgaaggaa gtcgtgcttc aaacaatcag
    11341 gcagtatatc gaaacactga tggaaacaga cgaaatctta acatatctgg atacattgga
    11401 tataaaagaa tcagaaatta tcctatatga tgaagaaata cagagcaaat acaaggaact
    11461 ggaacgatat gcaagacttt tgacatccct atgcgttgac cgtcaggatg gagtggtttc
    11521 tgatgctgaa tttgtggaat ttaaaggtgt ctatgaagaa
//
