LOCUS       c00019_gnlPro..        14274 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FAEBFOCD_19.
ACCESSION   c00019_gnlPro..
VERSION     c00019_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 04:04:58
            Original ID  :: gnl|Prokka|FAEBFOCD_19
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14274
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14274
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[103:4274]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      104..4274
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..14274
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14274
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="acetate2butyrate"
                     /region_number="1"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             complement(3..77)
                     /locus_tag="ctg19_1"
                     /transl_table=11
                     /translation="MALEEYKGVFVFAQQVDNVLDGVAF"
     CDS             complement(104..886)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 159.1;
                     E-value: 3.7e-49)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_2"
                     /sec_met_domain="ETF (E-value: 5.3e-49, bitscore: 159.1,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIVVCIKQVPDTKGGVKFNPDGTLDRAAMLAIMNPDDKAGLEAA
                     LRIKDETGAKVTVLTMGLPKADAVLREALAMGADEAVLVTDRVLGGADTWATSTTIAGA
                     LRNLDYDLIITGRQAIDGDTAQVGPQIAEHLGLPVISYAADIKVEGDSVVVKRQYEDRY
                     HELKAKMPCLVTALSELNEPRYMTPGGIFDAFDKEVTVWGRADLKDVDDSDLGLKGSPT
                     KIAKASDKVAKGAGEKVNLDPAESVAYLIGKFKEKHII"
     CDS             complement(943..2097)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_3"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 5e-52, bitscore:
                     168.6, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.8e-30, bitscore:
                     97.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.5e-39, bitscore:
                     126.6, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTLDKKHEMARSLFKEFAETEVKPLAQETDETEAFPAETVKKM
                     QKYGFMGIPVPKEYGGQGCDPLTYVMCVEELSKVCATTGVVVSAHTSLCIDPIMTYGTE
                     EQKQKYVKPLATGEKLGAFALTEPGAGTDAQGAQTKAVLDGDEWVLNGSKCFITNGKVA
                     DVYIVIAITSITEDKRGRKKKNFSAFIVDKGAPGFSFGTKEKKMGIRGSSTYELIFEDC
                     RIPKENLLGPEGKGFPIAMHTLDGGRIGIAAQALGIAEGALDRAIAYTKERKQFGRSIA
                     QQQNTQFKLADMAARIEAAQLLVYKAAMAKATQKVYSVEAAKAKLFAAETAMAVTTEVV
                     QLFGGYGYIREYDVERMMRDAKITEIYEGTSEVQRMVISGALLK"
     CDS             complement(2127..2999)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_4"
                     /sec_met_domain="HCDH (E-value: 1.5e-34, bitscore: 111.1,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 1.1e-62, bitscore: 203.6,
                     seeds: 60, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVGVIGAGTMGQGIAKAFAQVEGYEVALCDIKQEWAEGGKEKIK
                     KGYARLVEKGKMTQEAVDGILAKITPGLKEDLCKDCDLIVEAAFENMEVKKTTFKELDE
                     IAKPDCIFASNTSSLSITEIGNGLNRPMVGMHFFNPADRMKLIEVIAGVNTPDETVSAI
                     KKISEEIGKTPVQVNEAAGFVVNRILIPMINEAAFIKMEGVSDIAGIDAAMKLGANHPM
                     GPLELGDFIGLDICLAIMDVLYKETGDSKYRACPLIRKMVRGGNLGAKSGKGFYVYNAD
                     RTKTPVDAQ"
     CDS             complement(3093..4274)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_5"
                     /sec_met_domain="Thiolase_N (E-value: 4.1e-97, bitscore:
                     317.1, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Thiolase_C (E-value: 1.3e-50, bitscore:
                     162.8, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKVVLAGACRTAIGKMGGALSNTPAADLGAIVIKEALRRANVK
                     PEMVDEVKMGCVIQAAQGQNVARQAAIKAGLPIEVPAITINVVCGSGLKCVNDAATMIM
                     AGEADIVVAGGMENMSMAPYAMTKARFGYRMNNATIIDTMVNDALTDAFNHYHMMITAE
                     NVCDKYGITREELDEFSANSQQKCEKAIAEGKFDDEIVPVPVKVKKEIVDFVKDEGPRA
                     GTTAESLAKLKCCSGKEGGLVTAGNASGINDGAAAIVVMSEEKAKELGVTPMATWVAGA
                     LGGVEPEIMGVGPVASTRKVLAKTGLSIDDMDLIEANEAFAAQSIAVARDLKFDMSKVN
                     VNGGAIALGHPVGASGCRILVTLLHEMQKRDAKRGLATLCIGGGMGCSTIVER"
     CDS             complement(4620..5774)
                     /locus_tag="ctg19_6"
                     /transl_table=11
                     /translation="MRHNFLRRILGGILTGCILVTATVHAGTTQKDIDKAKDQITDLKK
                     QKEDAKDQVDSLTNEKQGLESDLSGLNGQLNTITSDMNQLEQQAAQKEDEINTTAEDLK
                     RSEERSAEQYEDMKVRIQYIYENGNQSVWDMLIHVSSIAEFLNQAEYTSAINQYDRNML
                     TAYQELTEQIKKQKKELEEQKEELTVLQQEKQKEQEKVNSLIEDTQKKIQESSEKIEDA
                     QSDVESIDAKIEKMIEYEKQLEIQKAKEDAARLAAIKKQEQENRSNVTYAPAQSDAYLL
                     AAIIQCEAWGEPYDGKLAVGSVIMNRVRSSYFPNTVSGVIYQGGQFSPVASGRLAYRLE
                     QGVDSDCMSAAQAVLGGMSTTNCLYFRVNNGIIEGTVIGNHVFY"
     CDS             5985..7280
                     /locus_tag="ctg19_7"
                     /transl_table=11
                     /translation="MQFVKTADLKPGMRLAKPIYNKMGVLLYERDTLLTMQGINSIENF
                     GLIGIFILEPAEPVPPLSREDLEFEQFQTIYVFKLKENMDRLQANQAPVSLSDLVRDIQ
                     THYGSLDHKLNFAQNLRSSADFVYKHSISVGILCAMITNQMHLPAAEQTALITAALLYD
                     FGYLYVPQTVLDKGDDLTTADKDFIQLNLERGYETLRPDRGDYKFPVHTLDIIQQIIFK
                     NSRTLKVKEPADNIRLLVDILAVADEFDHLTAMNINKPPISEIAAMGRLKKDKATYNPL
                     VLSALAECIHILPTGACVDLSDGEKALVLAENPADFLHPMVLKFSTNMIYDLSDPVINK
                     SLKITDIMKTMDNRIALDKDSVKHFVSDAYIKETADRFRKVKLQIAQHNQSKLEQKAAS
                     ALMSSASVIPQDALGTEKPLAQKKPRKKMKLR"
     CDS             complement(7471..10677)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CPSase_L_D2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_8"
                     /sec_met_domain="CPSase_L_D2 (E-value: 2.7e-83, bitscore:
                     271.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRNHDIKKVLVIGSGPIVIGQAAEFDYAGTQACRSLKEEGVEVV
                     LVNSNPATIMTDKDIADQVYIEPLTVSVLEKIIAKEKPDSVLPTLGGQAGLNLGMELEE
                     KGILEKYNVRLIGTTAETIFKAEDRQAFKDTMEKIGEPCAASQVVHNVQDGIKFTNTIG
                     YPVVLRPAYTLGGSGGGIAHDENELVEILTNGLRLSRVGEVLVERCIAGWKEIEYEVMR
                     DANGNCITVCNMENIDPVGVHTGDSIVVAPSQTLGDKEYQMLRTSALNIISELNITGGC
                     NVQYALNPDSFEYCVIEVNPRVSRSSALASKATGYPIAKVAAKIALGYTLDEIKNAITG
                     KTYASFEPMLDYCVVKIPRLPFDKFITAKRTLTTQMKATGEVMSICNNFEGALMKAIRS
                     LEQHVDSLMSYDFTGLSDKELNEQLHVVDDRRIWVIAEALRRGVSYDEIHEITKIDRWF
                     IDKLAILVEMENQLKNEPLTVELLKEAKRIEFPDSVIAKLTGKTEKEIHDMRYENGIVA
                     AFKMVDTCAAEFEASTPYYYSVFGSENEAIETNPKKKVLVLGSGPIRIGQGIEFDYCSV
                     HCTWAFAKEGWETVIINNNPETVSTDFDIADKLYFEPLTPEDVESIVKLENPDGAVVQF
                     GGQTAIKLTESLMKMGVKILGTKAEDVDAAEDRELFDEILEKTQIPRAAGGTVFTAEEA
                     KEVANRLGYPVLVRPSYVLGGQGMKIAFNDDEIEEFIGIINRIAQDHPILVDKYLQGKE
                     IEVDAVCDGTDILIPGIMEHIERTGVHSGDSISVYPAPTISDHVKETIVEYTKRLAQAL
                     HVIGLINIQFIAMDEQVYVIEVNPRSSRTVPYISKVTGIPIVDLATKVIIGDTIRGLGY
                     EPGLAPTADYIAIKMPVFSFEKLRGAEISLGPEMKSTGECLGIAKTFNEALYKAFLGAG
                     VTLPKYKQMIMTVKDADKPEAVGVAKRFEALGYKIYATRSTAKYLQEHGVNALRVNKIS
                     QESPNVMDLILGHKIDLVIDTPTQGNGDKTRDGFLIRRNAIETGVYCITAMDTANALAR
                     SLETATDDLTPVDIATVKNL"
     CDS             complement(10724..11782)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_9"
                     /sec_met_domain="GATase (E-value: 6.8e-47, bitscore: 152.2,
                     seeds: 97, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAHLILEDGNVFTGTSIGSTREVISEIVFNTSMTGYLEVLTDPS
                     YAGQAVVMTYPLIGNYGITPDMESGRPWPDGYIVRELSRMPSNFREEGTIQDFLTKYDI
                     PGIAGIDTRALTKILREKGTMNGMITTNNNYNIEEIIPRLKAYTTGNVVDKVTCSEKRV
                     LKGNGKRVALLDLGAKNNIAQSLNKRGCEVTIYPAHTTAEEILATNPDGIMLSNGPGDP
                     KECKEIIAEIKKLYDSDTPIFAICLGHQLMALATGADTHKMKYGHRGGNHPVKDLETGR
                     VYISSQNHGYVVDTDTLDPVIAKPAFVNVNDGTNEGLSYVGKNIFTVQFHPEACPGPQD
                     SAYLFDRFISMM"
     CDS             complement(12124..12744)
                     /locus_tag="ctg19_10"
                     /transl_table=11
                     /translation="VQVILLIIAVSVDVFVACVACGSEQIKIGSAAALCISTVCSGILG
                     ISLYAGMALQGVLLKKYALYLSFFGLLAVGIFKLTEYAIRKYIERHKFLCKKVKISFSQ
                     LSFILSIYNNPVMADRDHSATMSCVEAVFFALAMSLDGMFGGLGAGFTGKNIYFTVMGS
                     FVVSFCAVLCGCRIGMQASKRWKTDVSWLGGVLFVILAFQKMI"
     CDS             complement(12889..13239)
                     /locus_tag="ctg19_11"
                     /transl_table=11
                     /translation="MTLSECYEEMGADLHEVLRRLKTEERIGKFLKLILKDTNYESLCK
                     ALEEKNYEQAFTYIHNLKGLAMNLGLTPLLVPAQELCEELRDGEPERELKPLLDEVAAA
                     YQKVLGIVERLD"
ORIGIN
        1 tcaaatgcaa cgccatctaa tacgttatct acctgctgtg caaagacaaa tactccttta
       61 tattcttcta atgccatgtt attcaccact tttccttttt ttattagata atgtgtttct
      121 ctttgaattt accgatcaaa tatgctacgg attctgccgg atcaaggttt actttctcac
      181 cagcaccctt tgcaacttta tcagatgctt ttgcaatctt agtaggagat ccctttaaac
      241 caagatcaga atcgtcaaca tcctttaagt ctgctctgcc ccaaacggtt acttctttgt
      301 caaatgcatc gaagattccg cccggtgtca tgtaacgcgg ctcatttaat tcagaaagag
      361 cagttaccag acaaggcatt tttgctttta actcatgata tctgtcttcg tactgacgtt
      421 ttacaacaac agaatcaccc tctactttga tgtctgctgc gtaagagata accggaagtc
      481 caagatgctc agcgatctga ggaccaacct gtgcagtatc accatcgata gcctgacgtc
      541 ctgtgatgat caagtcatag tctaagttac gaagtgcacc agcgattgtg gtagatgttg
      601 cccatgtatc agctccacct aatacgcggt ctgttacaag aactgcttca tcagcaccca
      661 ttgctaatgc ttcacgaaga actgcatcag cctttggaag tcccatggta agaactgtaa
      721 cttttgctcc tgtctcatct ttgattctaa gtgctgcttc aagaccagct ttatcatctg
      781 ggttcatgat agcaagcatt gctgctctgt caagcgttcc atccgggttg aacttaacgc
      841 cgccctttgt atcaggaacc tgtttaatac atactacgat attcatgtat ttttcactcc
      901 ttatgtttta tatgtttaaa ttttacgcgg attgattcga aattacttta acagtgcacc
      961 ggagattacc atacgctgga cttcgcttgt accctcgtag atctcagtga tcttagcatc
     1021 acgcatcata cgctctacat cgtactctct gatatatccg tatccaccga ataactgaac
     1081 aacctcagtt gtaacagcca ttgcagtctc tgctgcgaat aattttgctt ttgcagcttc
     1141 tacagaatat actttctgag tagcttttgc cattgctgct ttgtaaacta aaagctgtgc
     1201 agcttcgatt cttgcagcca tatcagcaag tttgaactgt gtattctgct gctgtgcgat
     1261 tgaacgtcca aactgttttc tctcttttgt ataagcgata gctctgtcta atgcgccctc
     1321 agcgatacca agtgcctgag cagcaatacc gatacgtcca ccatcaagtg tgtgcattgc
     1381 gatcgggaaa ccttttcctt ccggtcctaa cagattctct ttcgggattc tgcagtcttc
     1441 gaagatcagc tcataagtag atgatccacg gatacccatc ttcttctctt ttgttccgaa
     1501 tgagaaacca ggagctccct tatctacgat aaatgcagag aagtttttct tctttctgcc
     1561 tctcttgtcc tctgtgatgc ttgtgatagc gattacaata taaacatctg caactttacc
     1621 attggtaatg aagcattttg atccatttaa tacccactcg tcaccatcta aaacagcttt
     1681 tgtctgtgca ccctgtgcat cagtaccagc acccggctca gttaatgcga atgcacctaa
     1741 cttctcgcct gttgcaagtg gttttacata tttctgtttc tgctcttctg taccatatgt
     1801 catgatcgga tcgatgcaga gagatgtatg tgcagataca acaacacctg tggttgcgca
     1861 aactttagat aactcttcta cgcacataac gtatgtaaga ggatcacaac cctgtccacc
     1921 atattctttc ggaaccggga ttcccatgaa tccgtatttc tgcattttct taaccgtttc
     1981 agccgggaaa gcttctgtct catctgtttc ctgtgcaagc ggttttactt ctgtttcagc
     2041 aaattccttg aataaggaac gcgccatttc atgtttcttg tctaaagtga aatccatgat
     2101 ctaattttcc tccataaata tttattttac tgagcatcga ccggagtctt tgtacgatca
     2161 gcattgtata catagaatcc cttgccgctc tttgctccaa ggttaccacc acgaaccatc
     2221 ttacggatca gtgggcatgc acgatatttg ctgtcgcctg tctctttgta aagtacatcc
     2281 atgatagcaa ggcagatatc aagaccgatg aaatcaccta actctaacgg tcccattggg
     2341 tggttagcac caagtttcat agctgcatcg ataccagcga tatcggaaac accttccatt
     2401 ttgatgaatg cagcttcgtt gatcattggg attaagatac ggtttacaac gaaaccagca
     2461 gcctcattaa cctgtaccgg agtttttccg atctcttcag aaattttctt aatagcggaa
     2521 acagtttcat ccggggtatt cacaccagcg ataacctcga tcagtttcat acggtctgcc
     2581 gggttgaaga aatgcatacc aaccattgga cggtttaatc cgtttccgat ctctgtgatg
     2641 gaaagactgg atgtgttaga agcgaagata caatctggtt ttgcgatctc gtctaattct
     2701 ttgaaagtag ttttctttac ttccatgttc tcgaaagctg cctctacgat cagatcacag
     2761 tctttgcaaa ggtcttcttt taaacctgga gtgatttttg caaggatgcc atcaacagct
     2821 tcctgtgtca tttttccttt ttctactaat cttgcataac cttttttgat tttctctttt
     2881 ccgccttcag cccactcctg cttgatatcg caaagtgcta cttcatatcc ttctacctga
     2941 gcaaatgctt ttgcaatgcc ctgtcccata gttcctgcac caataacgcc aaccttcatt
     3001 tcggttacct cctgaaaata attatgttaa ctgtatgttt gaaaaatgca atccccggga
     3061 agtcattccc cgggaattac tataaaaaac tattatctct caacgattgt agagcatccc
     3121 ataccaccgc cgatgcaaag tgtagcaaga cctctcttag cgtctctctt ctgcatctca
     3181 tgcagtaatg taacaaggat acggcatccg gaagcaccta ccgggtgtcc taatgcgatt
     3241 gcaccaccgt ttacgtttac ttttgacata tcgaatttca gatctcttgc tactgcgata
     3301 gactgagctg cgaatgcttc gtttgcttcg attaagtcca tatcatcaat agataaacca
     3361 gtttttgcta atacttttct tgtagaagca acaggtccaa cacccatgat ttcaggctca
     3421 actccaccaa gagcacctgc tacccatgta gccattggtg taacaccaag ctcttttgct
     3481 ttttcttcac tcataacaac gattgctgct gcaccatcgt tgataccgga agcgttacct
     3541 gctgtaacaa gtccgccctc tttaccggag cagcatttta attttgctaa agactcagca
     3601 gttgtaccgg cacgtggtcc ctcatctttc acgaaatcaa cgatctcttt tttcacttta
     3661 acaggaaccg gaacgatctc atcatcaaat ttgccttcag cgattgcttt ttcacatttc
     3721 tgctggctgt ttgctgagaa ctcgtcaagt tcttctcttg taatgccata tttatcacat
     3781 acgttctctg cagtgatcat catatgatag tggttgaatg catctgttaa tgcatcattt
     3841 accattgtat cgatgatcgt tgcattgttc atacgatatc caaaacgagc ttttgtcata
     3901 gcatatggtg ccatagacat gttttccata ccacctgcaa caacgatatc agcttcacct
     3961 gccatgatca tggtagctgc atcattgaca cattttaaac cagaaccaca aacaacgttg
     4021 attgtgattg ccggaacttc gattggcagt cctgctttga ttgctgcctg acgtgcaacg
     4081 ttctgtccct gagctgcctg gattacacaa cccattttta cctcgtcaac catctccggt
     4141 ttaacgtttg ctcttcttaa agcctctttg ataacgattg cacctaagtc tgctgctgga
     4201 gtattgctta atgctccacc cattttaccg attgcggtac ggcaggcacc tgctaaaact
     4261 actttctttg ccattttgaa ttctcctttc aatttaacac aaagctctgc ttttgcagag
     4321 aatttgtttc tttctcttta aagttgccga aaaatgctgt taatttttta acaatctttt
     4381 ttaaaaaaat aaattcaaac tttcggttga aatttatctt tttttctttc attttaaaaa
     4441 gcttatttgc tatgtaatca gctatttttc tgcatttctt gtactttctt atgctaacat
     4501 atttcacaat taattgcaat agctttcttt atttttcatc tttgtaaaca attttttact
     4561 tcctttttgc tccattttgc ggggtttttt gttaaatttt tatcatttta tcattttgtt
     4621 taataaaaca catgattacc tataactgtt ccttctataa tgccgttatt cacacgaaaa
     4681 tacagacaat ttgttgtgct cattccaccc agaaccgcct gtgccgcact catacaatcg
     4741 gaatcgactc cctgctccag acggtatgca agacgaccgc tggcaaccgg agagaactgc
     4801 cctccctgat aaatcacacc ggaaaccgta ttcggaaaat aggagcttct gacacggttc
     4861 atgatcacgc tgcccaccgc aagttttcca tcatatggct cgccccatgc ctcacactgg
     4921 atgatggcag ctaacagata cgcatcgctc tgtgccggtg cgtatgtcac attcgacctg
     4981 ttttcctgtt cctgcttttt gatggctgca aggcgtgcag catcctcttt tgccttctgt
     5041 atctcaagct gcttttcgta ttcgatcatt ttctcgatct ttgcatcgat cgattccaca
     5101 tcggactgtg catcttcaat tttctcgctg gattcctgta tcttcttctg cgtatcctcg
     5161 atcaggctgt tgactttttc ctgctctttc tgtttttcct gctgtaatac agtcagttct
     5221 tccttctgct cctcgagttc ctttttctgt tttttgatct gctccgtgag ctcctgatat
     5281 gccgtaagca tatttctgtc atactgattg attgcacttg tatattccgc ctgatttaaa
     5341 aattctgcga tggaggacac atgaataagc atgtcccata cagactgatt gccattttca
     5401 taaatatact gaatgcgcac tttcatatct tcatactgtt ctgcagatcg ttcctcggaa
     5461 cgtttcagat cttccgccgt cgtattgatc tcgtcttctt tctgcgctgc ctgctgctct
     5521 aactggttca tatcagaagt gatcgtattt aactgtccgt tcagtccgct aaggtcgctc
     5581 tccaatccct gtttttcatt ggtcaggctg tccacctgat ctttcgcatc ttctttctgt
     5641 ttcttaaggt ctgtgatctg gtcttttgcc ttatcaatat ctttctgtgt cgttcctgca
     5701 tggacagttg ccgtaacaag tatgcagccg gtcagtattc ctcccaggat tcttctcaaa
     5761 aaattgtgtc tcatgctgtt cctttcggct gaacagtaag ctttctgcta ctgttgtatt
     5821 tttcgttcat tgtatttctt ctattaatat ggtattatag catgtaaagc acaatatgaa
     5881 tattaatttt ttcacatacc attattgggg gaatattcag gcatctgatg tctggatatg
     5941 gtataaaaag agcctgataa tcatcacagg gggaggattt acctatgcaa tttgtaaaaa
     6001 cagcagattt aaaacccggc atgagacttg caaaaccaat ctacaataag atgggtgttc
     6061 ttctttatga aagagacaca cttttaacca tgcagggtat taacagtatc gaaaattttg
     6121 gtctgatcgg tatttttatt cttgagccgg cagagccggt accgcctctt tccagagagg
     6181 atcttgaatt cgaacagttc cagactatat atgtttttaa attaaaagaa aatatggatc
     6241 gtctgcaggc caatcaggca cctgtttcgc tgagcgatct cgtcagagac atccagacac
     6301 attacggcag tcttgatcac aaattaaatt ttgcacaaaa cctgcgaagt tctgcagatt
     6361 ttgtttacaa acattccatc agtgtcggca ttctctgtgc gatgatcaca aatcagatgc
     6421 atctgcctgc tgcagaacag acagccctta tcacagctgc gcttctctac gattttggtt
     6481 atctgtatgt accacagaca gtgttagaca aaggggatga ccttacaaca gcagataagg
     6541 attttatcca gctcaactta gagcgcggtt atgaaacact ccgcccggac cgtggtgatt
     6601 ataaattccc ggtacatacg cttgatatta tccagcagat catttttaaa aacagccgta
     6661 ctttaaaagt caaagaaccg gcagacaata tccgtcttct cgtcgatatt ttagcagtag
     6721 cggacgaatt tgaccatctg accgcaatga acattaacaa accgccaatt tcagaaattg
     6781 ctgccatggg acgtctgaaa aaggataaag ccacctacaa tccgctcgta ctttccgctt
     6841 tagcagaatg tatccatatt cttcctaccg gtgcatgtgt agatctttcc gatggcgaaa
     6901 aagcccttgt gcttgcagag aatccggctg attttcttca tccgatggta ctgaagtttt
     6961 ccacaaacat gatatacgat ttaagtgacc cggtgatcaa caaatcttta aagatcacag
     7021 atatcatgaa aaccatggac aaccgtatcg cattggataa agattctgta aagcattttg
     7081 tttccgatgc ctacatcaaa gaaacggcag accgtttccg caaggtcaag cttcagattg
     7141 cacagcacaa tcaaagtaaa ctggaacaaa aagcggcaag cgccttaatg agtagtgcat
     7201 ctgtgatccc gcaggatgct ttgggcacag aaaaaccact ggcccaaaag aaaccgcgca
     7261 aaaaaatgaa actccgttaa tccgcgcgac ttttttctat atgttggagt ggatattccg
     7321 gcgatataaa aaacgacatg aaagcaattt cttaactgct ttcatgtcgt tttttcatgt
     7381 tgtcgccaat atccatattc cgcaaaagca aaaacagcac gcctcctttt ggatttgtgc
     7441 tgttttttct atattataag attcaaaaaa ctacaagttc tttacggtcg caatatccac
     7501 cggtgtcaga tcatcggtcg cagtctctaa gctgcgtgct aacgcatttg ccgtatccat
     7561 tgctgtgata cagtaaacac ctgtctcgat tgcatttctc cggatcagga atccgtctct
     7621 ggtcttatca ccatttccct gtgtcggtgt gtcgatgaca aggtcgatct tatgtcctaa
     7681 gattaagtcc ataacgttcg gtgactcctg ggagatcttg ttgacacgaa gtgcattgac
     7741 gccgtgctcc tgtaaatatt ttgcggtact tctggttgcg taaatcttgt agccaagtgc
     7801 ctcaaaacgt tttgcaacac cgactgcttc cggcttatct gcatctttga cggtcatgat
     7861 catctgtttg tatttcggta aagtcacgcc tgcgccgagg aatgctttgt agagagcctc
     7921 gttgaaggtc tttgcaatac caaggcactc accggttgat ttcatctccg gtcctaagga
     7981 gatctcagcg ccacgcagtt tctcgaagga gaataccggc atcttgattg caatgtaatc
     8041 tgcggtcggt gcaagtcccg gctcatagcc aagtccgcgg atagtatcac cgataattac
     8101 tttcgttgca aggtcaacga tcggaatacc ggttactttg ctgatgtatg gcacggttct
     8161 cgaagaacgc gggtttacct caatgacata tacctgctcg tccatagcga tgaactggat
     8221 attgatcagt ccgatgacat gcagtgcctg cgccagacgt ttcgtatact caacgattgt
     8281 ctcttttaca tggtcactga tcgtcggtgc cgggtatacg gaaatactgt ctccggagtg
     8341 tacaccggta cgttcgatat gctccatgat accaggaatt aagatatcgg ttccgtcaca
     8401 tacagcatcg acctcgattt cttttccctg taaatattta tctacgagaa tcgggtgatc
     8461 ctgtgcgata cgattgatga taccgataaa ttcctcgatc tcatcatcgt tgaatgcgat
     8521 cttcataccc tgtccaccga gtacatagga aggtcttacc agtaccggat agccgagacg
     8581 gtttgcaact tcttttgctt cctctgcggt aaatacggtt ccacctgccg ctcttgggat
     8641 ctgtgttttc tctaagatct catcgaaaag ctcacggtcc tctgccgcat cgacatcctc
     8701 tgcttttgtt ccaaggatct taacgcccat cttcatcaga ctctcggtta atttgatcgc
     8761 ggtctgtcca ccaaactgca cgacagctcc gtccgggttt tccagcttta cgatgctctc
     8821 tacatcttcc ggtgtcagag gctcaaaata aagtttgtca gcaatatcaa agtcggtaga
     8881 aactgtctcc gggttattgt taatgataac cgtctcccat ccctcttttg caaatgccca
     8941 ggtacagtgt acggaacagt aatcaaactc gataccctgt ccgatacgga taggtccgga
     9001 accaagtaca agtacttttt tcttcggatt tgtctcaatg gcttcgttct cgcttccgaa
     9061 tacggaatag tagtacggtg tggatgcctc aaactctgcg gcacaggtat ctaccatctt
     9121 gaatgctgcc acgatgccat tttcataacg catatcatgg atttcttttt cggtctttcc
     9181 tgtcagtttt gcaataacac tgtccgggaa ttcgatgcgt tttgcttctt ttaataattc
     9241 tacagtcaaa ggctcattct ttaactggtt ttccatctca accaggatgg caagtttatc
     9301 aataaaccag cggtcaatct ttgtgatctc atggatctca tcataactta cgcctctgcg
     9361 gagtgcctct gcgatcaccc agatacggcg gtcatccact acatgcagct gctcgtttaa
     9421 ctctttatca gaaagtccgg taaagtcgta agacattaaa ctgtccacat gctgctctaa
     9481 ggaacggatt gctttcatca atgcaccctc aaagttattg cagatactca taacctctcc
     9541 ggttgccttc atctgtgtgg tcagggttct ctttgccgtg atgaatttat caaatggaag
     9601 tctcggaatc tttacaacac aatagtcaag catcggctcg aaacttgcgt aagtttttcc
     9661 ggtaattgca tttttgatct catctaaggt gtaacctaat gcgatctttg cagcaacttt
     9721 tgcgatcggg tatccggttg ctttggatgc aagtgcagaa gaacgggata cacgcgggtt
     9781 aacctcgatg acgcagtact caaagctgtc cggattcaat gcatactgta cgttacatcc
     9841 tccggtgata tttaactcgg aaataatatt taatgcagat gtacggagca tctggtattc
     9901 cttatcgcca agtgtctggg aaggtgcaac aacgatggaa tcaccggtat gtacaccgac
     9961 cggatcgata ttttccatgt tacacacggt gatacagttg ccgttcgcat cacgcattac
    10021 ctcatactcg atctctttcc atcctgcgat acagcgctct accaatacct cgccgacacg
    10081 ggaaagacgc agaccatttg ttaagatctc taccagctca ttctcgtcat gcgcaatacc
    10141 accgccgctt ccgccaaggg tatatgccgg acggagtaca accggataac cgatcgtatt
    10201 ggtaaacttg ataccatctt gtacgttgtg tacgacctgg gatgctgcac aaggctcacc
    10261 gatcttttcc atggtatctt tgaatgcctg acggtcctct gctttaaaaa tcgtctctgc
    10321 tgttgtaccg atcagtctga cattatattt ttcaagtatg cctttttcct ctaattccat
    10381 accgaggttt aatccggcct gtccacctaa agtcggcagt acgctgtccg gtttttcttt
    10441 tgcgataatc ttctctaaga cggataccgt aagcggctca atgtaaacct gatctgcaat
    10501 atctttatct gtcatgatcg tcgccgggtt tgagtttacc agcacaacct caacgccttc
    10561 ttcttttaat gagcggcatg cctgtgtacc tgcatagtca aactctgcag cctgtccgat
    10621 tacgatcggg ccggaaccaa ttactaaaac tttttttatg tcatgatttc ttggcattaa
    10681 ttcttcctcc taaaatttgt taaacaataa cgtaagaatt tttctacatc atcgaaataa
    10741 aacgatcaaa caagtatgca gaatcctgcg gtcccggaca cgcttccgga tggaactgta
    10801 cggtaaaaat gtttttgcct acataggaaa gtccctcatt ggttccatcg tttacattca
    10861 caaatgccgg tttcgcgatc accggatcaa gtgtatccgt atctaccaca taaccgtgat
    10921 tctgggagga aatatatact cttccggttt ctaaatcttt taccggatgg ttgccgccac
    10981 ggtgtccgta tttcatctta tgtgtgtcag cgccggttgc aagtgccatc agctgatgtc
    11041 ctaagcagat tgcaaagatt ggtgtatcgg agtcatataa ttttttgatc tcagcaataa
    11101 tctccttgca ctccttcgga tctccaggtc cgttgcttaa catgattcca tccggatttg
    11161 ttgcaaggat ctcttctgca gtcgtatgtg ccggatagat cgtcacttca cagccacgtt
    11221 tatttaaaga ctgggcaata ttattttttg ctccaaggtc aagcaaagca actcgcttgc
    11281 catttccttt taatactcgt ttttcactgc aggtaacttt gtccacaaca ttacctgtcg
    11341 tgtatgcttt taatctggga ataatttctt ctatattata gttattattc gtggtgatca
    11401 taccattcat ggttcccttc tcacgaagga tcttggtcag tgcacgggtg tcgatccctg
    11461 ctatacccgg aatgtcatat ttcgtgagga aatcctgaat cgttccctcc tcacggaagt
    11521 tactcggcat tcttgataac tcccttacga tatatccatc cggccacggt ctgcctgact
    11581 ccatatccgg tgtgattcca taatttccaa tcagcggata agtcataaca accgcctgtc
    11641 ccgcatacga cgggtcagtc agaacctcca gataacctgt catcgacgta ttaaatacga
    11701 tttcactgat gacttcccta gtagaaccta tacttgttcc ggtaaataca ttcccatctt
    11761 cgagtattaa atgagctttc attcgtttcc ctgtcctttc actttttttc caaaaaaaaa
    11821 aacgtcgccg tttttcttct ttttccatcc agacagtccc ctgactgaac tttcccttat
    11881 tagtacctat agtctttttc ttaaattgta aaaagtgtat catatcataa gacttttttc
    11941 aacctttttc caaaaacaaa tagtaccaag attttatgta tatttataca ttatttccaa
    12001 atccacagaa agcggcagta tgtgctgccc acacgcagga aaattttatt accaaaatgt
    12061 catgcaagac atacatagta acagactttc ctgattttcc cgcagcaatg ggcagccggc
    12121 gtcttatatc atcttctgaa acgcaagtat tacaaacaac acgccgccaa gccatgatac
    12181 atctgtcttc caccgcttag atgcctgcat gccaatcctg catccgcaaa gtacggcaca
    12241 gaaactgaca acaaaacttc ccatcactgt aaaataaata ttctttccgg taaatcctgc
    12301 accaagtcct ccaaacatcc cgtccaatga cattgcaagt gcaaaaaata cagcctccac
    12361 acacgacatc gtcgccgagt gatcgcggtc tgccattacc ggattgttgt agatactcag
    12421 aataaaactg agctgtgaaa aagagatttt gactttcttg caaaggaact tatgacgctc
    12481 aatatatttt ctgatcgcat actctgtcag cttaaaaatt cccactgcaa gcagtccgaa
    12541 aaaacttaag tataatgcat atttttttaa aagtaccccc tgtaacgcca tccccgcata
    12601 aagtgatatc cctaatattc cactgcagac cgtgctgatg cataacgctg ccgcagatcc
    12661 gatctttatc tgctcactcc cacacgccac acatgccaca aagacatcca cactgactgc
    12721 tatgatcaaa agaattacct gcactttttt ctacctcaga cataaaacct tctgttttat
    12781 catatgtcag agattcaaaa atgcatcttt acctttgata ctgttctcca tttccgaata
    12841 actcattaca aagaatcagc caaaatccca gcttttcaca ctgttatctc agtcaagtct
    12901 ttcgacaata ccaaggactt tctgatatgc cgccgccacc tcatccaaaa gcggtttaag
    12961 ctccctttcc ggttcgccat ccctaagttc ttcgcataac tcctgtgccg gaaccaaaag
    13021 cggtgtcagt cccagattca ttgccagccc ctttaaatta tgtatatatg taaacgcctg
    13081 ctcataattc ttttcttcca gcgccttaca cagcgactca taattcgtat ccttcagaat
    13141 cagttttaaa aatttcccga tcctctcctc cgtctttagc cgccgcagca cttcgtgcag
    13201 atccgcgccc atttcttcgt aacattcact taacgtcata ttcctctcca tttccacgct
    13261 gcttttgcgt atctcaaatt cgtgtgtaag cacaaatcta tgtgcaaaca atcttacttt
    13321 tcacactctt ccgttttcat aaaaagagca gacccgtgaa ccgccttcca tgtgatccac
    13381 gatctgctct tttttctatg ctacacgaat gacattcaac acttccccat atgctgcttt
    13441 tttgttctcc aaagcttctt ctgtcatcac ttcggtcaca aaaccaagct ctcctgtaac
    13501 accctgtgca tcaatatatt ctacatttcc aaatactttt tccacagatg ccttatctgt
    13561 acctgacact ctgacaaaga aacggttctc tgcgctgcgg taatctacca gctctaattt
    13621 ctttgagctc cactcaaccg gtatattctt gtcaacattc tttgccatct ccacaacatc
    13681 tgctacaacc gcactggctg tcggaagttt tccggcaccg cttccgtaaa acattgcatc
    13741 cccaagtaca tttccatgaa caaaaattgc attgaatacg ccgtttacat tgtataacgg
    13801 atgctctttc ggcagtaaga acggtgctac cattgccaca tatccgccat ctgttttttt
    13861 gctcgtagca agaagtttga ttgctcttcc catggctttc gcatatttga tatcggttgc
    13921 agaaatatgt gtgataccct ctgtgtggat atcctcaaaa tctacctgct gtccacagac
    13981 aagtgatgtc agaattgcaa tctttctgca ggcatcatac ccttcaatat cggctgtcgg
    14041 atctttctcc gcatatcctt ttgcctgtgc atcttttaat acctcatcaa aatcagcacc
    14101 tttttctgac atttcagtca tcatatagtt cgttgttcca ttgacgattc ctgtgatttc
    14161 ctcaatctca tcagcagtca gacaggaatt taacggacgg atgatcggga taccgccacc
    14221 gacgcttgct tcgaacataa agttaacatt tttctctttt gcaagtgcga tcag
//
