LOCUS       gnlProkkaOAECLNGP_2    13569 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OAECLNGP_2.
ACCESSION   gnlProkkaOAECLNGP_2
VERSION     gnlProkkaOAECLNGP_2
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 17:45:24
            Original ID  :: gnl|Prokka|OAECLNGP_2
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 100902
            Orig. end    :: 114471
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13569
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:8569]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8569
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13569
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13569
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             86..775
                     /locus_tag="ctg2_84"
                     /transl_table=11
                     /translation="MKLGIMQPYFMPYIGYFQLIKAVDKYVVYDDVNYIKGGWVNRNNI
                     LVNGEKKMFTITLKGASAYKHFNEIEIGDDFRKFMKTLELNYSKAPFYHETMELLYRII
                     MFPNRQLALFLANSFKEILDYLNIQTEILLSSDLPKDCSLKGKDKVLHICKLLSADTYY
                     NAIGGKQIYNKEDFMQNGINLKFVDTIIKRYPQQSKEFVPYLSIIDVLMNNSKEETCML
                     LDSFSLQ"
     CDS             775..1737
                     /locus_tag="ctg2_85"
                     /transl_table=11
                     /translation="MSIGGYFELEIREGKHFHQGAIKLSTARQCFEYILKARRYTKVYI
                     PYYTCDVIIEPLMKLNVKYEYYHINSLLDPVFDKKIESSEAFLYTNYFGLKQDTVLYLS
                     RFYPNLIVDNAQAFFAKPIEGVDTFYSARKFFGVPDGAYLYTTALLDIDFPIYNPIDNI
                     NYLIGRITDSAEGYYKDFQESEERMSNQEIHRMSVLSDKILSSLDYVSIIERRRFNYHL
                     LYSALTAFNKFDFSISENQNVPLIYPFYTSKAGLRQQLILEHVYVPQYWQNVVNKIDAK
                     CLEYSIANNMIALPIDQRYDEKTMNILIEKISNLNNHLS"
     CDS             1734..2729
                     /NRPS_PKS="Domain: NAD_binding_4 (91-233). E-value: 3e-07.
                     Score: 21.7. Matches aSDomain:
                     nrpspksdomains_ctg2_86_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     114.5; E-value: 1.1e-34)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_86"
                     /transl_table=11
                     /translation="MKKKIIIFGATGNTGSYLLEYALNFFNKEEYEIIASGRRETTFFS
                     KRGIPYYSVDITKEEDFDKLPMENIHAVMLLSAQIPSYMDTYCPIKYLDSIVIGGFNVL
                     EYCRKCHVDRIIYTQTVFDISLYSHDTILKPDMKPNFSYTGDHAIYVISKNTALDLIEH
                     YYQEYGLKKFIFRLPTIYSYSPYPYYFPNGVKTKRPIYQMIENAQKGLPIEIWGDPHYA
                     KDMVHVNDFSQMLCKAVEVEQESGFYNVGTGMPITLEEQIRTIISVFSPKESPSEVIYR
                     PDKVCGGGYIMNIENAKKELGYVPQYDCRKLFEDYKSEMEIKRFAELRLK"
     aSDomain        2007..2432
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg2_86_NAD_binding_4.1"
                     /evalue="3.00E-07"
                     /label="ctg2_86_NAD_binding_4.1"
                     /locus_tag="ctg2_86"
                     /protein_end="233"
                     /protein_start="91"
                     /score="21.7"
                     /tool="antismash"
                     /translation="YLDSIVIGGFNVLEYCRKCHVDRIIYTQTVFDISLYSHDTILKPD
                     MKPNFSYTGDHAIYVISKNTALDLIEHYYQEYGLKKFIFRLPTIYSYSPYPYYFPNGVK
                     TKRPIYQMIENAQKGLPIEIWGDPHYAKDMVHVNDFSQ"
     CDS             2730..3662
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_87"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2e-24, bitscore:
                     80.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGSITVSICCLTYNHEKYIRQCLDGLIMQKTEFDFEILVHDDAS
                     SDATQSIINEYVVAYPNLIKPILQIRNQYSQGISPLRQILFPLVKGKYVALCEGDDYWT
                     DPLKLQKQVNAMESDHSLAGCAHQSLVFYENGTPSHMFHHVKKQILKTKDLLDVRLFHT
                     ASFLFKKEVLDYIKDFNSSLYAGDRFLFLACSLKGNILYMPDVMCCYRKNAMGVTSRVS
                     YSLHVLDLKVPEYFHNKDLKFPYYRYLAFVHRAIFSESLDISLKKYIYHFTLFVKYSFS
                     YFPKNLKDIYKALYVSFWWLTKGQKYRIK"
     CDS             3659..5038
                     /locus_tag="ctg2_88"
                     /transl_table=11
                     /translation="MIAIIFLILFLIQILISNRLIIDSFSRKISFIYLLWWGTAIVIST
                     FDPAELYSVSMKTYMLLLINVWAFNWGFLCFGKIKKIRLKVTTDNSFYNLVIGNNKMIL
                     LLMLACIVTYYYAMKFALVIELYGAGEGRMMRFEAGELFTSNLEVYLYDFLIKPFTQFV
                     MLIVACMLLSKIKRRILLLSVLFLFLYASVGNGRGGLIVFLFYCFIIYYLRRELYYINL
                     LASKRKKWNFGVVSFVCLFVGVGIIVVVISYMTAQRMGFDTFSAEVVKIGFEELKSQAV
                     WYFLGPFRALDYSFRANYESITGFWYGRATMGGIDNLLKLVIHYLGGSYTIAHDEIGHL
                     LQNSKISVGNGIIFNYAYTNIIFHYLDFGYVGVLLFPFLYGFIVRYSIYKFTQKPTLLT
                     LGIMIYLVYISMFNIFSWEFQKPSSIIYVLLLLFFQYVYSHKFVILKLNGKKKGLCRHE
                     C"
     CDS             5001..6305
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 202.6;
                     E-value: 1.3e-61)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_89"
                     /sec_met_domain="CTP_transf_like (E-value: 8.9e-12,
                     bitscore: 39.8, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.3e-118, bitscore:
                     388.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 7.6e-63, bitscore:
                     206.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKKVYVGMSADIIHPGHLNIIHEASKLGHVTVGVLTDSAIASY
                     KRLPYLNFDQRSLIVLNLKGVDEVIPQTTLDYVPNLELIRPDFVVHGDDWKEGIQQETR
                     QRVIDTISKWGGKVIDVPYTKGISSTLLNTRLKEIGTTPEIRLKRLKRLIAAKSIVRIC
                     ESHSGLTGLIIENTSVEVNGVKREFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDLNDA
                     LECTTKPVIFDGDTGGKIEHFVFTVRTLERLGISAVIIEDKIGLKKNSLFGTDAVQTQD
                     TIEGFCDKIQAGKRAQITDDFMIIARIESFIAGKGLDDALGRALAYIKAGADGIMIHSK
                     DKSGEDIKNFCLALRKIHKSIPIVVVPTTYNHISEDELASWGVNVVIYANHMLRSAYPA
                     MLNTAKSILANARSYEANDLCMPIKEILELIPGTK"
     CDS             6337..7467
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 69;
                     E-value: 6e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_90"
                     /sec_met_domain="TPP_enzyme_N (E-value: 5e-16, bitscore:
                     53.2, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.3e-20, bitscore:
                     65.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISPNIFVDSLGAMQMDFFTGVPDSLLKNICAYLTDHLASEHNII
                     AANEGAAIGLATGYYLATRKIPVVYMQNSGLGNAVNPLMSLTDKEVYNIPLLLLIGWRG
                     EPGVKDEPQHIKQGKVTLPLLEAMGIRYAVLSQDEKKFISQLNVAKSYMDETREPFAFV
                     IQKDTFLEYSSENCEDERLSLKREAAIHFIAASLTEKDIIISTTGMISRELFEYRESTS
                     LEHERDFLTVGSMGHASQIALGIALKKRDCKVYCFDGDGSTLMHMGSLAIVGSLHPENY
                     VHVVFNNGAHDSVGGQPTVALDIDLCKIAQACGYEIVLSVSDNEGLCEALKKIQQIRGP
                     ILLEVKVRKGARKNLGRPANTPIQNKEAFMLFLDNL"
     CDS             7475..8569
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_91"
                     /sec_met_domain="Fe-ADH (E-value: 2.6e-75, bitscore: 247.9,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQRFFLGESSIKELIPILQEYTPDHIFLVRGKNSYEKCGAQAVL
                     ESVFVKLACGVTEFFDFEANPKIEDMEKGLSLLKEYPTNMIIAIGGGSVLDMAKLLRFF
                     YSYSGNPTGGEFEKKRQLIPLITLPTTAGTGSEATHFSVLYKDKVKYSVEHDAILPDVA
                     IVYPKFTYGNSKYLTSCTGFDALAQAIEAYWNVNATEESDKYAAKAIKLLWPNLPLVVN
                     SPTAEARNKVSEGSYWAGRAINITKTTAPHAFSYSFTTDYGYPHGHAVALTFPFFMRYN
                     IGNSDILLNPNINPYLYKIKMQKMLQWLNMECVDVAIAMKEYIRNLGLDIDISQIDISK
                     IVSSVNIQRLINNPYKVEAICLEE"
     CDS             8554..9270
                     /locus_tag="ctg2_92"
                     /transl_table=11
                     /translation="MSRGISEKEQRWLLVLSQVIEVLDKNNLLYFIDTGTLLGAVRDKM
                     FIPWDNDIDLAVIGGDTSTTNLLKVSKLLYALGFYVTLTKKEIAICSRDGVNLGIKLYK
                     KQASHYEACMGKVYRHRLFYSINLYLSGEVLYKKGFSFKYKAISLFVKFSQVFKLKLSC
                     IWQMKLLFWAKYDEKTVIIPFEFVDAIIDYNFYNIIVKVPNKPERYLAYRYGENWKVPK
                     QDYDYMIDDKSIINID"
     CDS             9277..9366
                     /locus_tag="ctg2_93"
                     /transl_table=11
                     /translation="MKTNFNIRSIIVINKIIINFFFRQYRWYL"
     CDS             9425..10540
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_94"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.7e-11,
                     bitscore: 38.5, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNILINCSNLKKGGGLQVADSVCSCLNTIPQHDFFLVLSSCMDDT
                     ADRVSEYKNVTVVRHDIRNSWYTLFWGRDKAMDNLVTRHNIGGVLTIFGPARWKPKCKH
                     LCGFARSHLVLNDSPYFQRMSWKELMIEKARNLYLYYYFKRGVTAFWTENPYISEKVKH
                     LFPTIKAYTVSNYYNQVFDDENTQIEHALPSFDGCTLLSINAPYPHKNLAIAIEVARYL
                     KKHYSEFSFRFVFTVTENDLPPIPSYLREHFCLIDKVSVAECPSLYRQADIMFQPTLLE
                     CFTATYVEAMRMQVPILTTDLPFAHGLCGNAAVYYSPLDAEDCAKSIYKMAVDTSFQDY
                     LVGEGIKQLKSFDNYNRRAEKLIDLISNLDD"
     CDS             10555..11628
                     /NRPS_PKS="Domain: NAD_binding_4 (10-144). E-value:
                     2.6e-07. Score: 21.9. Matches aSDomain:
                     nrpspksdomains_ctg2_95_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 105;
                     E-value: 8.3e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_95"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.2e-107,
                     bitscore: 353.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2e-07, bitscore:
                     24.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFKDKVLLITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQD
                     DMRHHLQNPKVKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVI
                     GTDNVLESAIAHGVKNVVVLSTDKAAYPINAMGISKAMMEKVAIAKGRALGEEAGTTIC
                     CTRYGNVMASRGSVIPLWVEQIKNGRPITVTDPNMTRFMMTLDDAVDLVIYAFEHGHNG
                     DLFVQKAPAATLDVLAQALKETYAQVDPKYGETEVKTIGTRHGEKLYETLVTREEMAKA
                     VDMGDYYRIPCDTRDLNYDKFFTEGNEDIARIEDYHSHNTARLDVEGMKKLLLKLRFIR
                     EDLGMEEKAKSAEIKSE"
     CDS_motif       10582..10638
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg2_95_0001"
                     /evalue="1.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg2_95"
                     /protein_end="28"
                     /protein_start="9"
                     /score="11.1"
                     /tool="antismash"
                     /translation="LITGGTGSFGNAVLRRFLD"
     aSDomain        10585..10986
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg2_95_NAD_binding_4.1"
                     /evalue="2.60E-07"
                     /label="ctg2_95_NAD_binding_4.1"
                     /locus_tag="ctg2_95"
                     /protein_end="144"
                     /protein_start="10"
                     /score="21.9"
                     /tool="antismash"
                     /translation="ITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQDDMRHHLQNPK
                     VKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVIGTDNVLESAI
                     AHGVKNVVVLSTDKAAYPINAMGISKAMME"
     CDS             11729..11950
                     /locus_tag="ctg2_96"
                     /transl_table=11
                     /translation="MAATVLNSVQQHLLKMFAFDGSEERLNEVKEVLTKYFSQKLDDRL
                     NDLWDSGVLNQEKLDELRKIDVRTLPKR"
     CDS             11947..12351
                     /locus_tag="ctg2_97"
                     /transl_table=11
                     /translation="MNRIVLDTNSLIQCISPKSRYRKIWDCFLDGTNQLCVSDEILNEY
                     EEILERLAGVEIAKLVIDVILNNPYTLFFTPYYNFNLIKSDPDDNKFVDCAIVANAKFI
                     VTEDHHFHILKQYNFPKVSFIGLDDFCHSL"
     CDS             12392..13540
                     /NRPS_PKS="Domain: NAD_binding_4 (101-190). E-value:
                     2.9e-09. Score: 28.2. Matches aSDomain:
                     nrpspksdomains_ctg2_98_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 87.3;
                     E-value: 2.1e-26)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_98"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 5.1e-09,
                     bitscore: 30.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILVTGSRGFVGRNLVSQLHNIRDGKARNYGIAGEELAIYEYDM
                     DSDPAELDVYCRQADFVFNLAGVNRPKDASEFMKGNFGFASTLLDTLKKHGNTCPVMIS
                     SSTQAALDNPYGESKRAGEQLLFEYSKETGAKVLVYRFPNVFGKWCRPNYNSAVATFCN
                     NIAHDLPIRVNDPSVVMHLVYIDDVVDELISALSGREHRNGDYCEVPVVHTITLGGIVE
                     LIRSFRQMPGTLSVPDLSDAFTKKLYSTYLSYLPEERFSYPLKMNVDDRGSFTEIIRTS
                     DCGQFSVNISKPGVTKGQHWHHTKNEKFVVVSGHGLIQLRKIGTEEVVSFEVSGGRMEV
                     VEMIPGYTHNIVNLSETEDLVTFMWCNECFDPARPDTYSEKV"
     aSDomain        12695..12961
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg2_98_NAD_binding_4.1"
                     /evalue="2.90E-09"
                     /label="ctg2_98_NAD_binding_4.1"
                     /locus_tag="ctg2_98"
                     /protein_end="190"
                     /protein_start="101"
                     /score="28.2"
                     /tool="antismash"
                     /translation="MISSSTQAALDNPYGESKRAGEQLLFEYSKETGAKVLVYRFPNVF
                     GKWCRPNYNSAVATFCNNIAHDLPIRVNDPSVVMHLVYIDDVVD"
ORIGIN
        1 aaatggcaaa aagtgtaatc tgcttgccaa tgtattgtgg attgtcgaat gaagatgttg
       61 aaagaatttt aaatctgata ttgaaatgaa attaggtata atgcaacctt attttatgcc
      121 ttatataggt tatttccagc taattaaggc tgttgataaa tacgttgtat acgatgatgt
      181 taattatatt aaaggagggt gggtgaatcg taacaatata ttggtaaatg gtgaaaagaa
      241 aatgtttact atcactttga agggggctag tgcctataaa catttcaatg aaatagagat
      301 aggagatgat tttcgtaaat ttatgaaaac attggaattg aattactcta aagctccttt
      361 ctatcatgaa acaatggaat tgttgtatag gataattatg tttccaaata gacaattggc
      421 tctcttcttg gctaatagtt ttaaagaaat tttagattat ctaaatattc agactgaaat
      481 attgctatct tcagatttac ctaaagattg ctctttaaaa ggaaaggata aagttcttca
      541 tatttgtaag ttactatcgg cagatactta ttataatgct ataggtggaa aacaaatcta
      601 taataaggaa gactttatgc aaaatggtat taatttgaaa tttgtagata cgataataaa
      661 aaggtatccc cagcaatcta aagaatttgt tccatattta tcaataatag atgtactaat
      721 gaataattct aaagaagaaa cttgtatgtt attagattca tttagtttac aatgatgtca
      781 ataggtggct attttgaact ggaaatacgt gaaggaaaac attttcatca aggtgcaata
      841 aaactgagta ctgctcgtca atgctttgag tatatattaa aagctagacg gtatacaaaa
      901 gtgtatattc catattacac ttgtgatgtg ataatagaac ctctcatgaa attaaatgta
      961 aagtatgaat attatcatat aaatagttta ctggatcctg tgtttgataa aaaaatagaa
     1021 agctcagagg cttttctata tactaattat ttcggcttaa aacaagatac tgttctttat
     1081 ttatctcggt tttatcctaa cttaatagtt gataatgcac aagctttttt tgcaaaacca
     1141 attgaagggg tagatacatt ttattctgcc cgtaaatttt ttggagttcc agatggcgct
     1201 tatttgtaca caactgcgtt actggatatt gatttcccga tttataatcc tattgataat
     1261 attaactact tgatagggcg tataactgac tctgcagagg ggtattataa agattttcaa
     1321 gaatctgaag aaaggatgtc aaatcaagag atacatagaa tgtctgtatt gtctgataaa
     1381 attttgtctt ctttggatta cgtctcaata attgaaaggc gtcgttttaa ttatcatctt
     1441 ctctacagtg cattaactgc atttaataaa tttgatttta gtatttctga aaatcaaaat
     1501 gtcccgttga tatatccttt ttatacgagc aaagctgggc ttcgccaaca attaatatta
     1561 gagcacgtat atgtacctca atattggcaa aacgtagtga ataagataga cgctaaatgt
     1621 ctggaatact caatcgcgaa taatatgatt gcattgccta tagatcagag atatgatgaa
     1681 aaaacaatga atatattaat tgaaaaaata tctaacttaa ataaccattt atcatgaaaa
     1741 agaaaattat tatttttgga gcaaccggta atacagggtc ttatttgtta gaatacgcat
     1801 taaatttctt taataaggaa gagtatgaaa taatagcttc aggacgtcgc gaaactactt
     1861 ttttttccaa aaggggaata ccatattatt ctgtggacat tacgaaggaa gaagattttg
     1921 ataagcttcc aatggaaaat atacatgcag ttatgctact ctctgctcaa ataccttctt
     1981 atatggatac ttattgcccc ataaagtatt tagattctat tgtaatagga ggatttaatg
     2041 tattagagta ttgccgcaaa tgtcatgtag ataggataat ttatactcaa accgtttttg
     2101 atatttcatt gtattctcat gatactattt taaaacccga tatgaaacca aattttagct
     2161 atacgggtga tcatgctata tatgtaattt ccaaaaatac tgctttagac ttgatagagc
     2221 attattatca agaatacggt ttgaaaaaat tcatttttag gcttccaaca atatatagct
     2281 atagccctta tccgtactac tttcctaatg gagtcaagac gaagcgacct atttaccaaa
     2341 tgattgaaaa tgctcagaaa ggactaccta tagagatatg gggagatcct cattatgcaa
     2401 aggatatggt tcatgttaac gattttagtc aaatgttgtg taaagctgtt gaggtggaac
     2461 aagaaagtgg cttttataat gtgggtacag gaatgccaat tacattagaa gaacaaattc
     2521 gcactattat tagtgttttt tcgcctaagg agtcaccatc tgaagttata tatagaccag
     2581 acaaagtttg tggtggtggg tacataatga acattgaaaa tgcaaagaaa gaattaggat
     2641 atgtgcctca atatgattgt cgtaagttgt ttgaggatta taaaagtgaa atggaaataa
     2701 agcgttttgc tgaattaaga ttaaaataaa tgaacggttc aataacagtt agcatatgtt
     2761 gcttgacgta taatcatgaa aaatatataa ggcagtgttt agatggcctt ataatgcaaa
     2821 aaacagaatt tgattttgaa attcttgttc atgatgatgc gtcttctgat gctactcaga
     2881 gtattattaa tgaatatgtt gtggcatatc ctaatcttat taaaccaatt cttcagattc
     2941 gaaaccagta ttctcaaggt atttctccgt tacgtcaaat attatttcct ttagtaaaag
     3001 gtaaatatgt tgcgctttgt gagggggatg attattggac tgatccgttg aagttacaaa
     3061 aacaagtaaa tgcaatggag agtgatcatt cgttagcagg ttgtgcgcat caatctttag
     3121 ttttttatga gaatggaact ccatcccata tgtttcatca tgtgaaaaaa cagattttaa
     3181 aaactaaaga cttattggat gtaagacttt ttcatacagc gtctttcctt tttaaaaaag
     3241 aagtacttga ttatattaaa gatttcaata gtagtttata tgctggagat cgttttctgt
     3301 ttttggcttg ttcgttgaaa ggaaatattt tatatatgcc agatgtaatg tgttgttata
     3361 ggaagaatgc aatgggagtt acttctagag tttcttattc attacatgta ttagacctaa
     3421 aagttcctga atattttcat aataaagatt tgaaatttcc ttattacaga tatttggcat
     3481 ttgttcatag agctatattt tcagaatcac ttgacatttc cttaaagaaa tatatatatc
     3541 attttacttt atttgtgaaa tattcttttt cttattttcc taagaatctg aaagatatct
     3601 ataaggcttt atatgtttct ttctggtggt tgacaaaggg acaaaagtat agaatcaaat
     3661 gattgctata atttttctta ttctattctt aattcagatt ttgatatcta ataggcttat
     3721 aattgattct ttttcaagaa aaataagttt catatattta ttgtggtggg gaactgctat
     3781 tgttatttct acttttgatc cagctgaact atattctgtg tcaatgaaaa catatatgtt
     3841 attattgatc aatgtttggg cgtttaattg gggatttctt tgttttggaa aaataaaaaa
     3901 aatacgattg aaggttacaa cagataatag tttttataat ctggttattg gcaataataa
     3961 gatgatatta cttcttatgt tggcatgtat tgttacttat tattacgcaa tgaagtttgc
     4021 tctagttatt gaactatatg gagcgggcga aggtcggatg atgagatttg aggctggtga
     4081 actttttacg agtaatttag aagtatatct atatgatttt ctaataaaac cttttacaca
     4141 gtttgttatg ctaattgtag cgtgtatgct actttctaag attaaacgta gaattctgtt
     4201 gctatcggtg ctttttctgt ttttatacgc atctgttggt aatgggcgtg ggggattgat
     4261 tgtttttcta ttttattgtt ttatcattta ttatttaaga agagaattgt actatatcaa
     4321 tttgttagcc agcaaaagga aaaaatggaa ttttggtgta gtttcttttg tatgcttgtt
     4381 cgttggcgtt ggaataatag ttgtggttat ttcatatatg acagctcaaa gaatgggatt
     4441 tgatacattt agtgctgagg tcgtaaaaat aggttttgaa gaactaaaaa gtcaggccgt
     4501 atggtatttt ttaggtccat ttagagcttt agactattca tttagagcta attatgaatc
     4561 gataaccggg ttttggtatg gaagggcaac aatgggtgga attgataatt tattaaaact
     4621 tgtaatccat tatttaggag gaagttatac cattgctcat gatgaaatag gtcatctttt
     4681 gcaaaattca aaaatttcag ttgggaatgg aatcatcttt aattatgcat acactaatat
     4741 aatatttcat tatttggatt ttggttacgt tggcgttctt ttattcccat ttttatatgg
     4801 ctttatcgta cgatatagta tctataaatt tactcaaaaa ccaacattac tgactcttgg
     4861 tattatgata tatttggtct atatatcaat gttcaatatt ttttcgtggg aatttcagaa
     4921 gccttcctca attatttatg ttttgttgtt gctatttttt caatatgttt attctcataa
     4981 attcgtaata ttaaaattaa atggaaaaaa aaaaggttta tgtcggcatg agtgctgata
     5041 ttattcatcc aggtcatttg aatatcattc atgaggcttc aaaattgggg catgtaacgg
     5101 ttggtgtatt aacagattca gctattgcca gttacaagcg tttgccttac ttgaattttg
     5161 atcagcgctc attgatagtt ctgaatttga agggtgttga tgaagtaata cctcaaacta
     5221 ctcttgatta tgttccgaat ttggaattga ttaggcctga ctttgtagta catggtgatg
     5281 actggaaaga gggtattcaa caagaaactc gccagcgtgt gattgatact atctctaaat
     5341 ggggtggaaa agtgatagat gttccttata cgaaaggtat ttcttccact ttattgaata
     5401 ctaggttgaa ggaaatagga accactcccg aaattcgttt gaagcgactt aaacgcttaa
     5461 ttgctgctaa aagtattgtt cgtatctgtg aatctcatag tgggttaaca ggtttgataa
     5521 tagaaaatac cagtgtagaa gtcaacggag ttaagcgtga atttgatggg atgtggtcca
     5581 gtagtcttac tgattcgact tctaaaggta agcctgatat tgaagccgtt gacttgacaa
     5641 ctcgtcttca tgatttgaat gatgctttgg agtgtactac caaaccagta atttttgatg
     5701 gtgatacagg tggtaaaata gaacattttg tatttactgt tcgcacgctg gaacgtttag
     5761 ggatatcagc tgttattatc gaggataaaa taggtctgaa gaagaactcg ctttttggaa
     5821 cagacgctgt tcagacccag gatacaattg aagggttttg tgataaaatt caagcgggta
     5881 aacgtgctca gataacggat gattttatga taatagctcg tattgaaagt tttattgctg
     5941 gaaaaggttt agatgatgct ttaggacgtg cattagcata tattaaagca ggtgcggatg
     6001 ggattatgat ccatagcaaa gataagtctg gtgaggatat aaagaacttc tgtcttgctt
     6061 tacgcaaaat acataaatcc attccgatag tggttgttcc aactacttat aaccatatat
     6121 cagaagatga attggcttct tggggagtaa atgttgtaat atatgcaaat catatgctta
     6181 gaagtgcata tcccgctatg cttaatacgg cgaagtccat tcttgccaat gcacgctctt
     6241 atgaagccaa tgacttatgc atgcctatta aagaaattct ggaattgatt ccagggacta
     6301 agtaaataga ctctttaaaa ttaaattctt attattatga tttctcctaa tatttttgta
     6361 gactctcttg gcgctatgca gatggatttt tttactggag ttcccgattc tttattgaag
     6421 aatatatgtg catatttaac agatcacctt gcttctgaac ataacattat tgccgctaat
     6481 gaaggtgctg ctataggttt ggctacagga tattatttgg ctacgaggaa aattccagtt
     6541 gtttatatgc agaattcagg tcttggaaat gcagtaaatc ctttaatgtc attgacggat
     6601 aaagaagttt ataatattcc attgttattg ctaattggtt ggcgtggtga acctggtgtg
     6661 aaagatgagc cacaacatat taagcaggga aaagtcacac ttccattact tgaggcaatg
     6721 ggtatcagat atgctgtttt atctcaagat gaaaagaagt ttatatctca acttaatgtt
     6781 gcaaaatctt acatggatga gacaagagag ccttttgctt ttgtaattca gaaagacact
     6841 ttcttagagt atagttctga aaattgtgaa gatgaacggt tgtctttgaa acgcgaagct
     6901 gctattcatt tcatagcagc ttcattaaca gaaaaagata ttataatatc gacaacaggt
     6961 atgatatcac gtgaattatt tgaatatcgt gaatctactt ctttagaaca tgagagagat
     7021 tttttgactg taggttctat ggggcacgcg tcgcagatag cattgggaat agctcttaaa
     7081 aagagagact gtaaagttta ttgctttgat ggagatggtt ccactttgat gcatatgggt
     7141 tcgttagcaa ttgtcggttc tttacatccg gaaaactatg tacacgtagt ctttaataat
     7201 ggcgctcacg attctgtggg gggacaacca acagtcgctt tagatattga tttatgtaaa
     7261 attgctcaag cttgtggtta tgaaatagta ttgtctgttt ctgataacga aggtttatgt
     7321 gaagctctta aaaagataca gcaaatacgc ggccctattt tgttggaagt aaaggttcga
     7381 aagggagctc gtaagaattt gggaagacca gccaacactc ctatacaaaa taaagaggca
     7441 ttcatgcttt tcttagataa tttatagagt aattatggaa cagcgttttt ttttaggaga
     7501 gtcttctata aaagaattga ttcctatctt gcaagaatat actcctgatc atatatttct
     7561 tgtaagagga aaaaattctt atgagaaatg tggtgcacag gctgtgttag aatctgtttt
     7621 tgttaaatta gcttgtggcg tgacggaatt ctttgatttt gaagcaaatc ctaaaattga
     7681 agatatggaa aaaggacttt cattattgaa agaatatccg acaaatatga ttattgctat
     7741 aggtggaggt agtgtattag atatggcaaa attgcttcgt tttttttatt cctattctgg
     7801 taatcctacg gggggggagt ttgaaaagaa gcgacaatta attccattaa taacacttcc
     7861 tactacagct ggtacaggta gtgaagcaac tcatttttct gttttatata aagataaagt
     7921 aaaatattca gtagaacatg atgctattct tccggatgta gcgattgtat atccaaaatt
     7981 tacttatgga aattcaaaat atctaacatc ttgtacaggc tttgatgctc tagcgcaggc
     8041 gatagaagct tattggaatg tgaatgctac ggaagagtcg gataaatatg cggcgaaagc
     8101 aattaaactc ttatggccta atttgccatt ggttgtaaat tctcctacag cggaggctag
     8161 gaataaggtt tcggaaggct cttattgggc tggtcgtgca attaatataa ctaagactac
     8221 agctccacat gctttttcgt attcatttac aactgattat ggatatccgc atggacatgc
     8281 agtagcatta acatttccct tttttatgag atataatatt ggaaattcgg atatcttatt
     8341 gaatcctaat ataaatcctt acttatataa gattaaaatg caaaaaatgt tacagtggtt
     8401 aaatatggaa tgcgtagatg ttgcaatcgc tatgaaagag tatataagaa acttgggatt
     8461 agatattgac atatctcaaa ttgacatatc gaaaatcgta tcttctgtta atattcaaag
     8521 attaataaac aatccatata aagttgaagc gatatgtcta gaggaataag tgaaaaggag
     8581 caacgatggt tgttagtatt atcacaagtt attgaagttc ttgataaaaa taatttatta
     8641 tattttattg atactggtac tcttttagga gctgttagag ataaaatgtt tattccttgg
     8701 gataatgata ttgatttagc agttattgga ggagatacat ctactactaa tttgcttaaa
     8761 gtgtcaaaat tgttatatgc tttaggcttt tacgtcactt tgacaaagaa agaaattgct
     8821 atctgttcta gagacggggt aaatttagga attaaattat ataaaaagca agcaagtcat
     8881 tatgaagcat gtatgggaaa agtttataga catagactat tttattctat aaatttatac
     8941 ctctctggag aggtcctgta taaaaaaggc ttttctttta agtataaagc tatctcactc
     9001 tttgtgaagt ttagtcaagt ctttaagtta aaattgtctt gtatttggca aatgaagtta
     9061 ttgttttggg ctaagtatga tgaaaagacg gtgattattc cttttgagtt tgtagatgca
     9121 attattgatt ataattttta taatataatt gtgaaagtgc caaataagcc agaaagatat
     9181 ctagcatata gatatggtga aaattggaag gttcccaaac aagactatga ttatatgatt
     9241 gatgacaagt ctattataaa tattgattaa aaaaatatga aaacaaattt caacataagg
     9301 agtattattg taattaataa aattataatc aactttttct ttagacaata tagatggtat
     9361 ttataaatag cactttcatt tatacaccaa aattgggcac ttatatatta tattctcgga
     9421 acaaatgaac attctaataa attgctccaa tctcaagaaa ggtggagggc ttcaagtcgc
     9481 tgattcggtt tgttcttgtt tgaatacaat tccccaacat gatttttttt tagtattatc
     9541 ctcatgtatg gatgatactg ctgatagggt atcggaatac aaaaatgtca ctgtagtgcg
     9601 tcatgatata cgaaacagtt ggtatacatt gttttgggga cgtgataagg ctatggataa
     9661 tttggtaacc agacacaata ttggtggagt tcttaccata ttcggacctg caagatggaa
     9721 gccgaaatgt aagcatctat gtggatttgc cagatcccat ctcgttttga acgattctcc
     9781 ctattttcaa cgtatgtctt ggaaggaact aatgatagaa aaggcgagaa atctttattt
     9841 atattattac ttcaaacgtg gtgtgactgc tttttggact gagaatcctt atatttcaga
     9901 gaaagtaaag cacttgttcc ctaccataaa agcctatact gtatcgaatt attataatca
     9961 ggttttcgat gatgaaaata ctcaaataga acatgcctta ccgtcttttg acggttgtac
    10021 tttactgtcc ataaatgctc cttatcctca taagaattta gcaattgcta tcgaagtcgc
    10081 tcgatatctt aaaaaacatt attccgaatt tagttttcga ttcgttttta cggtgacaga
    10141 gaatgacttg ccacctattc cttcttattt gcgagagcat ttctgtctga ttgataaagt
    10201 tagtgtagca gaatgccctt ccttatatcg tcaggcagat ataatgtttc aaccaacttt
    10261 acttgaatgt ttcactgcca catatgtcga agcgatgcga atgcaagtgc caattttaac
    10321 tacagatttg ccatttgctc atggattatg tggaaatgca gctgtgtact attcgccgtt
    10381 agatgcagaa gactgtgcca aatcaattta taaaatggct gtagacacat cctttcaaga
    10441 ttatctggtc ggagaaggaa taaaacaact taagtccttc gataattata atcggagagc
    10501 agaaaaatta atcgatttga tatcgaattt ggatgattaa tacatattat atttatgtca
    10561 gtatttaaag acaaagtcct ccttataacc ggaggtaccg gcagttttgg taacgctgta
    10621 ttgcgtcgtt tccttgattc tgatatcaag gagattcgta tttttagtcg tgacgagaaa
    10681 aagcaggatg acatgcgtca tcacctgcaa aatcccaaag taaaatttta cattggtaat
    10741 gtccgtgacc gccagtctgt agacggtgcc atgatgggag tggattatgt gttttccgcc
    10801 gccgctttga agcaggttcc cagctgcgag ttctttccgt tgcaggctgt gcagaccaat
    10861 gtgatcggta cggacaatgt actggaatcc gccatagcgc atggggtgaa aaacgtagta
    10921 gtgctttcta ccgacaaggc ggcttacccc atcaatgcca tgggtatcag caaggccatg
    10981 atggagaagg ttgccatagc caagggccgt gcgttgggtg aggaagctgg tacaaccatc
    11041 tgctgtaccc gttacggcaa tgtgatggca agccgcggtt ctgtaattcc cttgtgggtg
    11101 gagcagataa agaacggcag gcccattacg gtaacggacc ccaacatgac ccgcttcatg
    11161 atgacgctgg acgatgccgt agatctggta atctatgcgt ttgagcacgg gcacaacggt
    11221 gacttgttcg tgcagaaagc tcctgccgcc accttggatg tactggcgca ggccttgaag
    11281 gaaacatacg cgcaggttga tccgaaatac ggtgagacgg aggtgaagac catcggcacg
    11341 cgccacggcg agaaactgta tgagacactg gtaacccgcg aagagatggc aaaggctgtc
    11401 gacatgggcg actactaccg catcccctgc gacacccgtg acttgaacta tgacaagttc
    11461 ttcacggaag gcaatgagga tattgcccgt atagaggact atcacagcca taacactgcc
    11521 cgcctggatg tggagggcat gaaaaagctt cttttgaaac tccgtttcat ccgcgaagac
    11581 ctcgggatgg aggaaaaggc gaagagcgcg gaaatcaaga gtgaataagt ctttaatttg
    11641 aataatacaa caggaaagaa agagggaatg tattgttcct ttagaaaaaa aaactatctt
    11701 tgccatattg aaactaataa ttgagaatat ggcagcaaca gtattaaatt cagttcaaca
    11761 acatcttttg aagatgtttg cttttgatgg ttcggaggag cgattgaatg aagttaaaga
    11821 agtgttgacc aaatattttt ctcagaagtt agatgaccgc ttgaatgact tatgggattc
    11881 gggagtttta aaccaagaaa aacttgatga actgagaaaa attgatgtcc gtacacttcc
    11941 gaagagatga atagaattgt attagataca aatagcttga tacagtgcat ttctcccaaa
    12001 agcaggtacc gtaagatttg ggattgcttt ttggatggaa cgaatcagtt atgcgtttct
    12061 gatgaaattc ttaatgaata tgaggaaata ttagaacgtt tggcaggtgt ggaaatagct
    12121 aagctggtga ttgatgtcat tctcaataat ccttatactt tgttctttac tccttattat
    12181 aacttcaatc tgataaaatc agatccggat gataataagt ttgtggactg tgcaattgtg
    12241 gctaatgcca agtttattgt tacggaagat catcattttc atatattgaa gcaatataat
    12301 ttcccaaaag taagttttat aggtttggat gatttctgtc attcactatg aatatcttct
    12361 cttttctgtg acaaacagaa cccattagtt tatgaaaatc ttagtgaccg gctcccgagg
    12421 gtttgtcggc cggaaccttg tatcccagct gcacaacatc cgtgacggga aagcccgcaa
    12481 ttacggcatt gcaggtgagg aacttgccat ttacgaatat gacatggaca gtgacccggc
    12541 cgaactggat gtctattgca gacaggctga ctttgtcttc aatctggcgg gcgtaaaccg
    12601 tcccaaggat gcgtctgagt ttatgaaggg gaacttcggc ttcgcctcca cgctgcttga
    12661 tacattgaag aagcacggca atacctgtcc ggtaatgatt tcctcttcca cgcaggccgc
    12721 actcgacaac ccttacggtg aatcgaagcg ggcaggggag caactgttgt tcgagtactc
    12781 caaggaaacg ggtgcaaagg tactggtgta ccgcttcccg aatgttttcg gcaaatggtg
    12841 ccgccccaac tataacagcg cggtggccac tttctgcaac aacatcgccc atgacttgcc
    12901 catccgggta aacgaccctt cggtggtgat gcatctggtt tacatagacg atgtggtgga
    12961 cgagcttatc tctgccctaa gcggcaggga acaccgcaac ggggattatt gcgaagtgcc
    13021 cgtggtgcat accattacct tgggcggcat tgtggaactg ataaggtctt tcaggcaaat
    13081 gcccggtacc ttgtccgtcc cggatttgag cgatgccttt acaaagaaac tctattccac
    13141 atacctctca tacctgcctg aagaacggtt cagctatccc ctgaagatga atgtggacga
    13201 ccgcggcagt tttacggaga ttatccgtac ttccgactgt gggcagttct cggtgaacat
    13261 ctccaagccg ggcgttacga aaggccagca ctggcaccat accaagaacg agaagtttgt
    13321 ggtggtgagc ggacacggtc tgatacagct ccgcaagata ggtacggagg aggttgtcag
    13381 cttcgaggta agcggcggga ggatggaggt cgtggagatg attcccggct atacgcacaa
    13441 tatcgtcaac ctttcggaaa cggaagacct ggtgaccttc atgtggtgca acgagtgttt
    13501 cgacccggca cgtccggaca cttattctga aaaagtctga aacgagttaa agaatatagg
    13561 aacagatgg
//
