LOCUS       c00013_gnlPro..        14173 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KCLINPHN_13.
ACCESSION   c00013_gnlPro..
VERSION     c00013_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 04:55:28
            Original ID  :: gnl|Prokka|KCLINPHN_13
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 32211
            Orig. end    :: 46384
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14173
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[42211:45701]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13490
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14173
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14173
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(463..1053)
                     /locus_tag="ctg13_40"
                     /transl_table=11
                     /translation="MSGLANAFLALLPPDQASLPAAGAEARWLADTAVVQSAAIARDNR
                     TVLFGWLNNILVNSNLRDRGLCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCV
                     YVNAAGKGLQGSIVLDAWKNCGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGME
                     HHLVWPGWARKRPILVQRIFQSDQQNEAKAAAE"
     CDS             1293..2903
                     /locus_tag="ctg13_41"
                     /transl_table=11
                     /translation="MLTIKNLTKSHAGRTLFRETEMTINWGERVALVGPNGAGKSTLFR
                     MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITPEMEQAIHTIRTAEN
                     ANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRPAREMSGGWIMRAYL
                     AKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHDRDFMDELVESVYDI
                     DNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFIDRFRSINSKAGQVQS
                     RIKQLEKMKIIQKPVARRKVFKFNFPQPPRSTQKVIELEKVCQSYGDRRVYENLDLLVE
                     RGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFSQARTENLNPENTVL
                     EEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLSLVKFLVDPPNLLLM
                     DEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLHVNRGTITAYAGGYD
                     YYLEKSGILDDEKGGITAE"
     CDS             2967..3485
                     /locus_tag="ctg13_42"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLVEPDEDGAPPGA
                     LRENEEAGQ"
     CDS             3590..4363
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_43"
                     /sec_met_domain="adh_short_C2 (E-value: 2.5e-75, bitscore:
                     244.9, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKNGFTVGSMQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILI
                     SRSPSSCGGAAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGIT
                     RDSLMLRMKEEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQA
                     NYAASKAGLIGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKE
                     QGSVEDIAALTAFLASDDARYITGQVIACDGGMTM"
     CDS             4387..5592
                     /locus_tag="ctg13_44"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSALLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPVA
                     GASLRMVAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPGAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDIMTMHRLWNFSKG
                     EP"
     CDS             5606..5806
                     /locus_tag="ctg13_45"
                     /transl_table=11
                     /translation="MTIALRTEQSSDHAETEHVTREAFWNYFVPGCHEHYLLHIMRVSP
                     SFIPELDAVAVHGSRIVGKHR"
     CDS             complement(5963..6178)
                     /locus_tag="ctg13_46"
                     /transl_table=11
                     /translation="MRDSCPPEGTEFPGAGGRIRFFPHGGNLLETFLRRNTGKLFLYRK
                     MPVKFGSALFVHMVHGSFHIAAFQAG"
     CDS             complement(6271..6480)
                     /locus_tag="ctg13_47"
                     /transl_table=11
                     /translation="LTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEM
                     VPEPATVSLGLLGLAALMMRRRRA"
     CDS             6512..6760
                     /locus_tag="ctg13_48"
                     /transl_table=11
                     /translation="VLAVGAAVPPAAYKYVLDVSCIKSITDWLTARKRYVNAASRSRGE
                     PSREEKLNVRLIPAAVVPVLVLQPMTELSEPFSTRKP"
     CDS             7186..7275
                     /locus_tag="ctg13_49"
                     /transl_table=11
                     /translation="MNYKYNILTLNIFNCLRIPNSLFKRKCIH"
     CDS             complement(7284..7568)
                     /locus_tag="ctg13_50"
                     /transl_table=11
                     /translation="LILDRSRTIVTDITSRLLVPYPLKVIPDNVRLLTSGVMETESFRV
                     PKSAVWEAKSEYPTMELSNREVAAVALRLMPVERIRVDNNFFMVSILIK"
     CDS             complement(7581..7730)
                     /locus_tag="ctg13_51"
                     /transl_table=11
                     /translation="MVRDPSVPSGVSTTGPLYEVLFHNPWSFRSVFRPTPQLTLLFLAL
                     NRAV"
     CDS             complement(7675..7917)
                     /locus_tag="ctg13_52"
                     /transl_table=11
                     /translation="LTNLFLGKEGVVDVELFDGFSQSCVHENLINLLVAEFQAAVEIVR
                     SAVAKIDAGAKISGDYGNGQGPFRAQRGVNDGPAV"
     CDS             complement(7914..8093)
                     /locus_tag="ctg13_53"
                     /transl_table=11
                     /translation="MFERIRKRPAHDFVSRPLNIGRRTVQAYALRRRIISAVSPSRPRE
                     AVAGSGMLAISLIS"
     CDS             8243..8413
                     /locus_tag="ctg13_54"
                     /transl_table=11
                     /translation="MPGQPEPEHAKPGFPQHPEQPILSAIHFPARSGSLRFPSVGNRLL
                     PRNREKEWENG"
     CDS             8443..8676
                     /locus_tag="ctg13_55"
                     /transl_table=11
                     /translation="MNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPD
                     EFLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(8710..9495)
                     /locus_tag="ctg13_56"
                     /transl_table=11
                     /translation="MVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSADGFRDYFVQLT
                     ECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLGIGEIGLNRNT
                     SHEMTIFEEHLDLAVHLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLDPCRVLVDHCE
                     EHTFPLVREAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADWGDSDPLALTA
                     LACELRRRGFSRQETERLFLENPETFMGQSPKFRKVSSR"
     CDS             complement(9528..9800)
                     /locus_tag="ctg13_57"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLLLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             10001..10702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_58"
                     /sec_met_domain="SucD_FumR (E-value: 2.5e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             10724..12682
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_59"
                     /sec_met_domain="FAD_binding_2 (E-value: 4e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.1e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             12660..13490
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.6; E-value: 9.2)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_60"
                     /sec_met_domain="Fer2_3 (E-value: 2.6e-23, bitscore: 74.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 8.3e-11, bitscore: 34.2,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.5e-06, bitscore: 19.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LPSAATSKDSQYINTQKKDYNMAKTLNLTLKVWRQENREAKGRIE
                     TYAAKDIPVDASFLEMLDIVNEGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPER
                     QVTTCQLHMRKFKDGDTVWIEPFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAP
                     NANNIAVEKVKADAAFDAAACIGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSK
                     RVLAMMKQMEAEGFGNCTNQYECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
ORIGIN
        1 aatgccgtga catggaacaa gaaaatctct tgatttctac ttgccaccat ttacattggt
       61 gccagcaaac ctccgtggat gcggaggttc cagtagttaa caaacactgt atttaattcg
      121 aattatgaag aacatcgcta tcctcgccat cgccggcgcc gcttgcctgg tcgcttcctg
      181 ctcccagcag cagcaacaac agcaaaccac cgctcctgct cccgctccgg ttgtgcaggc
      241 caagggcaag taagtttgca gcggggtttt gccctgcaac actagcaaat tatccaatta
      301 atccgcactc ggtgtacgca ctgagtgcgt ttttatttgc cctgagtccg gattccctcc
      361 gccatttgcc gattcgccgg gattttcctt aaaaacggcg gataccgcaa accgccgcgg
      421 cgcagcaccg tgtgccggtt cctgccggat caggcttccc ctttattcag cggccgcctt
      481 cgcctcattc tgctgatcgg actggaatat ccgctgaacc agaatggggc gtttcctggc
      541 ccacccgggc cagaccaggt gatgttccat gccgtaggaa tggccctccg gaaaggcctt
      601 ggaaacaaat ggttcccgcc agtcctcctc ccatttgccg ccttcccggt ccttctgggt
      661 cagcgtcacc agatgcccgc agttcttcca ggcatccaga acaatggagc cctgcaatcc
      721 cttccccgcg gcattgacat acacgcaact gtgctccctg cccgttccac ggtctcgaat
      781 cgtcagccct atgcggaaat acttcacggg gcggcggcgc aggtcccggt acaaatcctg
      841 ctggacctgc cagcacagcc ccctgtcgcg caggttggaa ttgaccagaa tattgttcag
      901 ccagccaaac agcacagtcc tgttgtcccg ggcaatcgct gcggactgga ccacggccgt
      961 gtccgccagc cacctggcct ccgctccggc agcgggaaga gaggcctgat ccggcggcag
     1021 cagcgccagg aaggcattag ccagcccgga catttgctgc tgcacgtaag tttgttgtat
     1081 ataatcctcc gccggaggag tacagcagga actccatccg cacaaaaggg cggcagcaag
     1141 caaaagcctg aatgtctgcg tggtcggcat ggcgcgccaa ggctagcaga ctacgcgtaa
     1201 aaatccagta aagctttcaa aaatgcctgc ctccgccctg acggctcttg ccttcccctt
     1261 tccatcccgg tagaatacat cctctcttca ccatgctgac gatcaaaaat ctcacaaaat
     1321 cccacgccgg acggaccttg ttcagggaaa cggaaatgac cattaactgg ggggaacggg
     1381 tggctctggt tggccccaac ggagcaggca aatccaccct gttccgcatg attctgggag
     1441 aagacacgcc ggacgaaggc tccatcagca tggatgaata cgccatcgtg ggctatcttc
     1501 cccaggaagc cagcgaaccg aaggatgaaa ccgttctgga aatcgccctg ggcatcacgc
     1561 cggaaatgga acaggccatc cacaccatcc ggacggcgga aaacgccaac aaaacggata
     1621 cgccggaata cgcggaagcc attgacactt tcaacgccgc caacggttac cagctggagc
     1681 ccaaagccaa gaaaattctc aaagggctgg cctttcggga aagcgacttc catcgccccg
     1741 cccgggaaat gtccggcggc tggatcatgc gcgcgtacct ggccaagctc cttgtcctgg
     1801 agccggacct cctgatgctg gacgaaccta ccaaccacct ggacctcctg tccctgctgt
     1861 ggctccagcg atacctgaaa aactaccccg gagccatcct gatgatttcc cacgaccggg
     1921 atttcatgga tgagctggtg gaaagcgtgt acgacatcga caacgaagaa ctggtggaat
     1981 accgcggcaa ttactcggac ttcctccaac aaaaggacgt gcgcttcgag cagcttcagg
     2041 cggcctaccg caaccagcag aaggaaatag cgcacattca ggaatttatt gaccgtttcc
     2101 gctccatcaa ttccaaagcc gggcaagtcc agagccgcat caagcagctg gaaaagatga
     2161 aaatcattca aaaaccggta gcccgcagga aagtatttaa attcaacttc ccccagcctc
     2221 cgcgcagcac ccagaaagtc attgagctgg aaaaagtctg ccaatcctat ggcgaccgca
     2281 gggtttatga aaacctggac ctgctggtgg aacgcgggga gcgcactgtt cttgtaggcc
     2341 cgaacggcgc gggcaaatcc actcttctca aaatcctggc gggcatcatc cccattgact
     2401 ccggacaacg cactcccggt accacgacgc gcatcggcta cttctcccag gcgcgaacgg
     2461 aaaacctgaa tccggaaaat accgtgctgg aggaaatcat gaaatgcagc gctgaaatcc
     2521 gggaggaaga agcgcgttcc atcctgggtt ccttcctgtt ccggaggctg gatgtggaaa
     2581 aacgcgtcag cgttctttcc ggcggggaaa aatcgcggct cagcctggtc aaattcctgg
     2641 tggatccgcc caacctcctg ctgatggacg agccgaccac ccacctggac cttttgtccg
     2701 tagaagccct ggtgcaggct ctgaagcatt atgaaggaac actggtcttc atctcccacg
     2761 atgtgcactt catccgttcc ctggcacaaa aaaccctgca tgtgaaccgg gggaccatca
     2821 ccgcctacgc aggtggatat gactactatc tggaaaagtc aggcattctg gacgatgaaa
     2881 aaggcggcat cacggcggaa taaggctctt ttttcagttt cccctttttc cttgccgtgg
     2941 atttcatcct gccttaaaag aacaggatga aggcttttct tgttcctctc ttatattctg
     3001 cgcttctgtc cggagcctct cttgcatttg gtgaaacggc cgccggaacg gcttcccccg
     3061 cagcagcggc tccggcggaa aaaattcctt ccgcggaatc cctgatcaac caggcctttt
     3121 cctttgccat caatatccag cagacgttgg caggcgttca ggacaaggaa agcgcggaca
     3181 acgccgtcaa aacgctgcag gacattcaga aggacatccg gcatttcctc cagcttcagg
     3241 ataaattgaa cgatgcggaa aaggagaaag aagacgcctt gatagaaaaa atggaaaaac
     3301 gaatggaaat gctggacaac cgctgcaggc aggaaggcaa acgcctgttt gaggcccgct
     3361 attacggttc cgccgcctta aaggacattt tggaaaattc ggatgaattc agcgacctgg
     3421 tagaaccgga tgaagacggg gcgccccccg gtgcactccg ggaaaatgaa gaggccggac
     3481 agtagccccc cgccccgttt ctcccccccc cctctttttt cattcccggc acgccccttc
     3541 cccgtatggg ttcctgcgcg gccaagtcca tttcaagctt gccggaaccg tgaaaaacgg
     3601 gtttactgtg ggcagcatgc aaaagttagc aggtaaaaca gccatcgtta ccggcgcggg
     3661 ccgcggaatc ggcaatgccg tcgcgcgccg cttcgcttcg gaaggagcca gggtcatcct
     3721 gatcagccgc agtccatcca gctgcggggg ggccgcagaa gaaatcaaca aggaatttcc
     3781 ggattcctgc aaggcctacc cctgcgacgt agcggattac gcggccgttc aggaaaccat
     3841 ggccgccatt ttgaaagact tcccgcagat tgacatcctg gtgaacaacg ccggcatcac
     3901 gcgggactcc ctgatgctcc gcatgaaaga ggaagactgg gatgccgttc tggacaccaa
     3961 cctgaaaagc gcgttcaata cggtcaaggc cctccagcgc gttctcatga aatccccggc
     4021 cgggcgcatc atcaacatga gctccgtcat cggtctcgtc ggcaacatcg gtcaggccaa
     4081 ttacgccgct tccaaggcgg gcctcatcgg tttcaccaaa tcactggctc aggaattcgc
     4141 tccgcgcaaa gtcacgtgca acgccattgc tcccggcttc atctccacgg aaatgtccaa
     4201 tgccattccc gacaatctca aggaagaaat cgttaagaaa atacctttga aagaacaagg
     4261 ttccgtggaa gatatcgccg ccctgacggc cttccttgcc tctgacgatg cccgttacat
     4321 caccgggcag gtcattgcct gcgacggagg catgacgatg tagggcattc cggttttctc
     4381 cattccatgc gcggcatttt ccttgtttcc tgctttctgg gaggaagcgc cctgctggcc
     4441 gggtgccggg aagaaaataa ttccccccgc ccggccacgg aagatgccgc gcgcattacc
     4501 agcgcacgcc agtggggaga aagccgatcc gcgctgcaaa aacgggaact ggaccgcgct
     4561 gccggtcctg cccttcccat tccggatgac ctgccgtccc gggagctggt cggcacaacg
     4621 cgccaaatcc atcagctcat tgaagcttcc ggaaatccgg cacgttttga atcctacacg
     4681 gaaacggttc ccgtggcggg agcttccctg cgcatggtcg ccataccggg aggaacgttc
     4741 ctcatgggga gtcccgcgga agagccgcac cggaaaccgg acgaaggtcc gcagcataaa
     4801 gtgagcatct cccccttctg gatctcggaa acggaaatcc cctgggaact ttatacggcc
     4861 ttcatggaaa acgggcgtcc gcgcgccaag gacggccagc ttctggagga acagccggat
     4921 gacgaactgt gggactccgt tacgcagcct accgccccct acaccgccat gaacctgggc
     4981 atgggccacg gctatgaaca cggtctgccc gccatctcca tgtcccacca cgccgccagc
     5041 aaattctgcg aatggctgag cgcccagacc gggcattact accgcctgcc cacggaggcg
     5101 gaatgggaat acgcctgccg ggccggctcc cccggcgcct attcttacgg aaacggggaa
     5161 gcctctctgg accagtacgc ctggtactgg aacaactcca atgaccgcta ccagaaaaca
     5221 ggctctaaaa aaccaaataa gtggggactc cgggacatgc acggaaatgt ggcggaatgg
     5281 gttttggact cttacgttcc ggatgcctac ggcaaacgga gcggcttgcc cgcgaaagac
     5341 cccctggtca tcatccccgg cgcccctcac atcgttcgcg gcggttcgtg ggaagacgac
     5401 ccggacagcc tgagaagcgc tgcgcgccgc gccagcaccc ccgcctggaa ccgtcaggat
     5461 cctcaaaacc ctaaaagcat ctggtacctg acggacggag gcatgatcgg gttccgcgtg
     5521 gtgcgcccca tgaacattcc ggacattatg acgatgcacc gcctctggaa tttctccaag
     5581 ggggagccgt aaagaacaac ctttcatgac cattgcatta agaacggaac aatcctcaga
     5641 ccatgccgaa acggaacatg tcacgagaga agcgttctgg aactatttcg tccccggctg
     5701 ccatgaacat tacctgctcc atatcatgcg cgtcagtccg tccttcatcc cggagctgga
     5761 tgcagtcgcc gtccacggca gccgcatcgt cgggaaacat cgttgatgca acgtccgtca
     5821 tcagggcaga cgatggaaaa gaatatgaag tgctgggcat ggggcccatt gccgttcttc
     5881 cgaaatacca gcgccgggga ataggacggc ggataatagg tatgcggcgg ccctccaggt
     5941 ctgtgagttg caaagggggt ccctatccgg cctgaaaggc cgctatgtga aagctgccgt
     6001 gtaccatatg gacgaaaagc gcgctgccga atttgaccgg cattttccgg taaagaaaaa
     6061 gctttccggt attgcgtctc aaaaacgttt ccagcaaatt gccgccatgc ggaaaaaacc
     6121 ggatacggcc ccctgccccc ggaaattccg taccttccgg agggcatgaa tcccgcatac
     6181 ggataagcaa ttcttcctct ctggatataa aaaacaagag ctgttccgca agaacagctc
     6241 tcatccgccg atttttcgcc atcaggaagc tcaagccctg cggcggcgca tcatcagcgc
     6301 ggccagtccc agcaggccca gggaaaccgt ggctggttcc ggcaccattt cccctcggat
     6361 ttccgtgaaa atcggggata ataagctgaa agtattggtt ccgttggctc ccgtaataac
     6421 aacagaatca ccaggcgctc cctcggcgtc ataatggccg cggatgccgg gagcagtcaa
     6481 tccgccgctg atcgttacgg tatctccttc cgtgttagca gtaggggcgg ctgttccccc
     6541 cgcagcatat aaatacgttt tagacgtatc ctgcatcaag tccatcacgg actggctcac
     6601 ggccaggaaa cggtatgtca atgccgcgtc aagaagcagg ggagaaccat ccagggaaga
     6661 aaaactgaac gtcagattaa tccctgctgc agtagttccc gtattggtgc tccagccgat
     6721 gaccgaattg tcggagccat tcagcaccag gaagccgtaa gtgacattag cgcccaaatt
     6781 gttggcggct ccgcgcagcg taaaactgtc cagtctaatc tctccggaca gggaggaggg
     6841 agaagaggaa tcggaaggag ccagggaaga agaccccagg ccaagataaa acccatggat
     6901 ggtactattg taattatccg taccgggagt gtaataatta aaaacggtcg ctgcctccga
     6961 ggaaacagca aagcttccca tcgcgattaa aaatgtcagt gttttcttca tatttattat
     7021 tccttttgga tggcaacttg tagcgaattt ggaattcccc aatcggattt ggaatccgtc
     7081 aagtaatgaa aaagaggcca aatcaatcat gaaaccaatg aataacaaag attgccccgt
     7141 catcttgaca aaaggaccag agatattaaa aaatcattat tttcaatgaa ttataaatac
     7201 aatatactaa ctcttaatat ttttaattgc ttgcggattc caaattcgtt attcaagcgc
     7261 aagtgcatac attgaatctt gcatcatttt attaagatac tgaccatgaa gaaattatta
     7321 tccaccctga ttctttcgac cggcatgagc ctaagcgcta ccgcggctac ctctctgttg
     7381 gatagctcca tcgtgggata ttcggacttt gcctcccaaa cggcggattt cggcaccctg
     7441 aaagattccg tttccatcac gcctgacgtc agcaatctga cgttatccgg gataaccttc
     7501 aacggatacg gtaccaacaa ccgcgacgtt atgtctgtga cgatggttct tgatctgtcc
     7561 aaaatcaaca ctccggagac ctataccgct ctgtttaacg ccaaaaacag cagtgtaagc
     7621 tggggcgtgg gcctgaacac ggaccggaaa ctccagggat tatggaacaa cacctcatac
     7681 agcgggcccg tcgttgacac cccgctgggc acggaagggt ccctgaccat ttccgtagtc
     7741 accggagatc ttggcacccg catctatttt ggcgacagcg ctacgtacta tttcaacagc
     7801 ggcctgaaat tcggcaacca gcaaattgat cagattctca tggacgcagg actggctgaa
     7861 tccatcgaac agctctacat ccacaactcc ctcctttccc aggaacaagt tggtcaactg
     7921 atgagtgaaa tcgccagcat tccggaaccc gccacggctt ccctgggcct gctgggactg
     7981 accgcgctga tgatgcgccg ccgcagggca taagcctgta ccgtccgcct ccctatattc
     8041 aaaggccggc tcacaaaatc gtgagccggc cttttcctta tccgttcaaa catctgccga
     8101 aaaaacagag gggaaaagct tccatttgct gcggtaccct cacggccagc acttgacggg
     8161 gaaatggcat tcaggctccc ccgggagggt catttcaaga gcttccggcc ccgccccact
     8221 tccgtacacg cccctttttc ccatgccggg acagccggaa ccggagcatg caaagcccgg
     8281 cttccctcag catccggaac agcccatcct ttcagcaatc catttccccg cacggtccgg
     8341 atcgctgcgg tttccgtccg tcggcaacag actccttccc cgaaacaggg aaaaggagtg
     8401 ggaaaatggc tgagcttgaa cctttatccc ccgttcccgt ccatgaacct tcaaaaacag
     8461 cagctgctac tgcgcctgtt ccggtatttc aaaagcagaa aaggagaacc gcgttttttc
     8521 aacaaacgga atatatgcct tctggccgcc gccggcgcct acatcctgac tcccgacgaa
     8581 ttcctgtttg acggaatcgg caggctgggc cttctggatg acgcggcggt catcctgggc
     8641 gccgtcctca ccgtcttttt cccggacggg gactagaggg ccgtaccctc cgccgcgcct
     8701 cgggcggaat tagcgggacg acactttccg gaacttcggg gactgtccca tgaatgtctc
     8761 cggattttcc agaaaaagac gttccgtttc ctgccgggaa aaaccgcgcc tgcgtagctc
     8821 gcaggccagg gccgtcagcg ccaggggatc ggaatccccc cagtccgccg cggaattggc
     8881 ccagacacgg tccattccgt acaattccag aatatccgcc gcccgcttgg gattcagctt
     8941 actggtggga taaagggtca gcccggccca gtagccggcc tccctcacca gcgggaaggt
     9001 atgttcctca cagtgatcca ccagcacgcg gcaagggtcc agatccggac ggtttttcag
     9061 ggcggaaaga atcattacgg tccccttaag cttgtcttcc agatggggag tgtgaatcag
     9121 cacaagctgg ttgaggtgca ccgccagatc cagatgctct tcaaaaatag tcatttcatg
     9181 ggaagtattc cggttcagtc ctatttcccc gatgccgagg acattgggcc ggtcaatgaa
     9241 ctccggaatc agcttcatca catcccgcgc gaaagccacg tcctgcgcct ccttgggatt
     9301 gatgcacagc catgtgtaat ggtccatgcc gaacttggcc gccctggcgg gttcgcattc
     9361 cgtaagctgt acgaaataat cccggaaacc gtccgcggac gaacggtcgt aaccggccca
     9421 gaacgccggt tcccctaccg ccaggcagcc ggcctgcgcc atggcccggt attcgtccgt
     9481 ggtgcggcac accatatgta tatgaggttc tatgaaagcc atcattctta tttgctgagg
     9541 ttcggggctc cgcaggccgc tttggctgcg gcggtttccg gcacggtgtc atccctgtag
     9601 gaaagggctt ccagaatggc ccggacgcgt ccggggccgg atgcggacaa gaggagaaga
     9661 acatccatca gggcatggta acggaaatcc gcctcccctt ccccgcggtc cacccggtcc
     9721 agaaatgcgg ccacatccag aacgccggcg cgcgccgctg cgaaatccgc gtccagcact
     9781 tcctttttac ttcttttcat gcacagacga tacgcctatg cggaaagcct cgtcaagccg
     9841 gaacaggcaa caaaatgata accattccaa actgataaac agcaacctct ttccccggct
     9901 tttcaaaaat ccgaaaagcg ccggaaattc aagaagaggc ttgccatccg ggcttgaacc
     9961 gggcatcctg tgaagacgca tttatttcat tagagcgcct atgaatgcac tagtaaaaac
    10021 catatgtaca ttcgtgacat cctccatcgg ccgcaaaatc attgtggctc tgacggggtt
    10081 atgtttggtc ttgttccttg cgggacacct ggcaggcaac cttctcatct tcggaggccc
    10141 tgaatggatc aacacctacg cccacggcct gcactccatg ccggaagcag ccctctgggg
    10201 aatccgcgcg gggcttgcgg tgatcttcat catccacgtc tggctgacca tccagctgaa
    10261 gctggaaaac catgcggccc gcgaacccta cgtgttcaag aacaccatca aggcgacgct
    10321 ctcctcccgc tacatgatct ataccggcct gaccgtcctg gtgttcctga tctaccacct
    10381 gtaccagtac accctgcgcg tgggatacga ccccgcccag ttcaccacct tcatttccga
    10441 cggtacggtg gaaacctttg acgtgtacaa gatgatcgtg accggattct ccaatgtatg
    10501 gtgctccgcc ttctacatcc tggccgttct gatgctgttc agccatctgc gccacggggt
    10561 acagtccatc ttccagactg tgggcgtcga ttcccgcaaa atccggccct tctacaactt
    10621 tatcgccatc gcctacggcg cgattatctg cctgggcttc atctccgtgc cggtctcggt
    10681 tcttctgggt atcatcaaat aaccatcaac tcctctcaaa gtcatgatta attttcccgt
    10741 aagcgactgg atgccggatg ccaaaattcc ctccggccct attcaggaca aatggtccaa
    10801 gtacaaactt gagtccaaac tgatcaatcc gaacaacaag cgcaagtaca cggtgcttgt
    10861 ggtaggttcc ggcctggctg gcgcctccgc tgccgccacg cttgccgaac ttggctacaa
    10921 cgtcaaatgc ttctgctacc aggacagccc ccgccgcgcc cactccattg cggcccaggg
    10981 cggcattaac gcagccaaga actaccagaa cgacggcgac tccgtttacc gcctgtttta
    11041 cgacaccgtt aaaggcggcg acttccgcgc ccgtgaagcc aatgtctacc gtctggcgga
    11101 agtctcctcc aacatcattg accagtgtgt ggcccagggc gttcccttcg gccgtgaata
    11161 cggcggcctg ctggacaacc gctccttcgg cggcgcccag ctcaagcgaa ccttctacgc
    11221 acgcggacag acgggccagc agctcctgct gggtgcctac caggccctgg aaaaggaagt
    11281 ggccaaggga cacattgaaa tgttctcccg ccatgaaatg atggatctgg tgctggtgga
    11341 cggcgaagcc aagggcatcg tcacccgcaa tctggttacc ggcgaaatca aatcctacgc
    11401 aggggatacc gtcctgctct gcacgggcgg ctacggcaac gtgttcttcc tgtccaccaa
    11461 cgcgatgggg tgcaacgtca ctgccgccta caaagcctac aagcgtggtg ccttcttcgc
    11521 caacccctgc ttcacgcaaa tccaccccac ctgcattccg gtcaaaggcg actaccagtc
    11581 caaactgaca ctgatgtcgg aatccctccg caacagcggc cgcatctggg tgcccaagtc
    11641 ccgtgaaacc gcagaaaaaa tccgtaagaa ggaaatcaag ccttccgatg ttcccgaaga
    11701 agaacgggac tactacctgg aacgcaagta tccctccttc ggcaacctgg ctccgcgcga
    11761 catttcctcc cgcgccgcca aggaagcctg cgacgacggc cgcggcgtgg ccgtcaccgg
    11821 caagggcgtc ttcctggatt ttgcggatga aatcaagcgc atgggccgcg aatggattga
    11881 cggccaatac ggcaatctgt ttgacatgta cgaagaaatc acggacgacg acccccatga
    11941 aacgcccatg atgatctacc ccgcctccca ttacaccatg ggcggcctgt gggtggacta
    12001 caacctcatg tccaacgtga aggggctgca tgtcctcggt gaagccaact tctccgacca
    12061 cggagccaac cgcctgggag cctccgccct gatgcagggc ctgtctgacg gctacttcgt
    12121 cattcccgcc acgctgcccg cttacctgac gaccaccaaa cccggcgccg tcaccaccgc
    12181 cgccccggaa ttcaaggctg cggaagacga agtgaaggaa cgcatcaaca agctcctgaa
    12241 tgtgaagggc accaagacgg tggactcttt ccaccgggaa ctgggcctca tcatgtggga
    12301 agactgcggc atggcccgca cggaagaaag cctgacccac gccattgaac gcattcccca
    12361 gctccgcaag gaattctggg aaaacgtgcg cgtaaccggc acggcggacg gcatcaacgc
    12421 ggaactggaa aaagcctgcc gcgtggccga cttcctggaa ttcgcccagc tgctctgcta
    12481 tgacgccctg aaccgccagg aatcctgcgg cgcccacttc cgcgtggaat accagctgcc
    12541 ggacggcgaa gctaagcgca acgacgatga atacgcctat gtagccgcct gggaatacac
    12601 tggcgtggac agcctgcctg ttctccacaa ggaaccgctg accttcgaga acgtgcacct
    12661 tgccatccgc agctacaagt aaagatagcc aatacattaa cactcaaaag aaagattata
    12721 acatggctaa aacactcaat ctcactctca aggtctggcg ccaggaaaac cgggaagcca
    12781 agggccgcat tgagacctat gccgccaagg acattccggt ggacgcctcc ttcctggaaa
    12841 tgctggacat cgtcaatgaa ggcctggtca aggaaggcaa ggaacccatc cattttgacc
    12901 acgactgccg ggaaggcatt tgcggcatgt gctccctaac catcaacggc attccccacg
    12961 ggccggaacg ccaggtgacc acttgccagc ttcacatgcg caagttcaag gacggcgata
    13021 ccgtctggat tgaacccttc cgcgcgaagg ctttcccaat cctgcgggac ctgatggtgg
    13081 accgctccgc cctggaccgc atcatcgccg ctggaggcta tattgacgtg cgtaccggtt
    13141 ccgcgccgaa cgccaacaac atcgccgtgg aaaaagtgaa agcggacgcc gcctttgacg
    13201 cggccgcctg catcggctgc ggcgcctgcg tggcctcctg taaaaacgcc tccgccatgc
    13261 tgttcacctc cgccaagatc gcccatctca atctgctgcc gcagggccag ccggaacgtt
    13321 ccaagcgcgt cctggccatg atgaagcaga tggaagcgga aggctttggc aactgcacga
    13381 accagtatga atgtgaagcc gcctgcccga aaggcatcag cgtggacaac atcgcccgcc
    13441 tcaaccgcga cttcatgcgg gccaacgcca aggaaggcct ctgtttctaa agaagattcc
    13501 ttcttaagac gctctgtaaa aactcccggc ggcatcggct gtcgggagtt ttttcattac
    13561 caggtttcct tgaaccagga ataaaatacc agacagttgc ttcctcatcg tcgcgcagcg
    13621 taaaaaattg ttacaccgga agggttccag taatccagga gaccgtactt ggaaatgccg
    13681 gacgaaacct aagcaagccc ccgtccgaca gcgacggccc ccatctttct ccgagagaaa
    13741 gaaaaatatt gattacagga attggactga tgcccggaag ggatggcctc ctgtcaaggg
    13801 ctcagcatga gaggaaaaca ttttctaaca aacagacaac attgatgtct attaagggaa
    13861 tgcactgagc gtaagaatta taatattatc ttttcgtgta aaataatgac catcttttat
    13921 aaaaaatcaa aaacatacaa ataaaattct atcgacaccg acttcggatc atactattaa
    13981 taaaacgatc aggaaagggc ggccacccct cgcttccttc attacccccg actcttgaat
    14041 acctgatgaa tccccctcat cgttcctcct ccgcccatcg ttctgccgtt cccggctacc
    14101 ggaaatggta ctttggagcc ggcggcagcc aatccggttc tactcgccgc gtgcgcttat
    14161 ccggccagcc gga
//
