LOCUS       c00023_gnlPro..        14880 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DJDDBOBH_23.
ACCESSION   c00023_gnlPro..
VERSION     c00023_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:53:37
            Original ID  :: gnl|Prokka|DJDDBOBH_23
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14880
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14880
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1440:4880]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1441..4880
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14880
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14880
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(228..1181)
                     /locus_tag="ctg23_1"
                     /transl_table=11
                     /translation="MKTAIFSIGVFLISLFLGSCQPSETSCSVVDTGKTLDYKIGDKLL
                     FSYNYTTVYPAPGVDSVYKRSGFIHPLKTLGGEVMTNCSPADHYHHFGLWYAWTKTTFE
                     GNEIDFWNLHKKQGTVRFRNFEHVSDNGFVATLDHVVYPDSPAEKVAMNERLEINIGTT
                     SLPGYYIDYHTTIRLASPSPITMEAYRYGGICIRTREDWNDQTAEMLTSEGLSRDEADG
                     SRARWCYYQGKAGNEKACILIVASPSNLNYPEPLRVWDKTVNKPAGDVMWNFSPTKQKA
                     FTLEPGKELSLSYRIYVLDKNINATTAEVLSDFERD"
     CDS             complement(1207..1368)
                     /locus_tag="ctg23_2"
                     /transl_table=11
                     /translation="MLNPHITQTIKEIFHQLEHCLLAGFICIRYHKRIVRNEKISFFCS
                     RYRQGLAG"
     CDS             1441..2115
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_3"
                     /sec_met_domain="SucD_FumR (E-value: 4.5e-67, bitscore:
                     217.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLLNSSIGKKLIMSISGLFLILFLVFHLCMNIAAVFSGEAYNVI
                     CGLLGSNWYALLGTLVLAAGVVVHFVYAIILTLQNRKARGNDRYAINARPKGVEWASQN
                     MFVLGVIVILFMVLHFTQFWYNMMFAELAGIHGDIHPQDGAAFINFYFQGNVVNTVLYL
                     IWFVALWFHLTHGFWSAIHTIGWNNTVWLSRWECISKWVATIICGLFAVITVIFYLNGV
                     GA"
     CDS             2154..4097
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 194.4; E-value:
                     1.1e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_4"
                     /sec_met_domain="FAD_binding_2 (E-value: 1.1e-59, bitscore:
                     194.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 7.2e-38,
                     bitscore: 121.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQIDSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERFAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFVEAEKAINARIAKLMNVKGKETVDSIHRKLGHI
                     MWEHVGMARDAEGLKEAIQMLKDLKKEFWSNVFIPGEANSLNVELDKALRLADFIEIGA
                     LMAHDALDRAESCGGHFRTEHQTEEGEAMRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     QFVVPQTRNYKK"
     CDS             4125..4880
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_5"
                     /sec_met_domain="Fer2_3 (E-value: 4.5e-26, bitscore: 83.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 1.3e-11, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.4e-05, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDIKVTLKVWRQKGPKDKGQFETYQIDKINQSVSFLEMLDILN
                     ERLVSEGKEPIVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFVSVNTGGVPDANAIPISKADADLAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFISAKLQD"
     CDS             5073..5231
                     /locus_tag="ctg23_6"
                     /transl_table=11
                     /translation="MKKTHCKYKVYLLNTQEFVITFYCKFATFCFKIDTVCGFTLLLYQ
                     QSIDSDT"
     CDS             complement(5204..6235)
                     /locus_tag="ctg23_7"
                     /transl_table=11
                     /translation="MKIGTIDLGERPVFLAPMEDVTDISFRLMCKRFGADMVYTEFVSA
                     DALIRSVNKTQQKLNVADEERPVAIQIYGRDVPTMVEAAQICEAAHPDILDINFGCPVK
                     RVAGKGAGAGMLRNIPLMLDITREVVKAVNIPVTVKTRLGWDADNRIIVDLAEQLQDCG
                     IAALSIHGRTRAQMYTGEADWTLIGEVKNNPRIQIPIIGNGDVTSAEICKQRFEQYGVD
                     AVMIGRGSIGRPWIFREVRHYLDTGETLPAESFSWYLDILKKQVEQSVERLDERRGILH
                     IRRHLAATPLFKGIADFKQTRVAMLRAETVEALFDILDSIPDKFHTGYGFQSDSQVSES
                     IDC"
     CDS             6368..6751
                     /locus_tag="ctg23_8"
                     /transl_table=11
                     /translation="VHSSNKKRIMVRLTSKEEEILGYFWAKGPLFVRELLDLQEESKPH
                     YNTLSTIVRSLEEKGYIGYKVYGNTHQYYALVSEDEYRRNSLKQVISKYYDNSYTRVVS
                     TLIEEEVLTIDELQKLIQQIKNK"
     CDS             6765..7397
                     /locus_tag="ctg23_9"
                     /transl_table=11
                     /translation="MDAFLLYILKSGICLTVFYVCFKALFSNDTFFRFNRWILLVGTGV
                     CMLLPLCRIQTARPFPLSRPVSQLEIVFYEEEMKAFPVPESKEEITIPTEQRNISVPWT
                     GIIGIAFLTGSGICLTTTILSFGKMYQLTRKNRKLKQGKYTLILTPDPISPFSWGRYIF
                     LSENDYRNHPNEILMHEKMHLRYNHSVDLIYMKRFFFCNGLILPYGY"
     CDS             7487..7750
                     /locus_tag="ctg23_10"
                     /transl_table=11
                     /translation="VKKAVGSSLYTLANSFNHSKIKKRITMMLKKKSNNWARLKLALLV
                     PVGFAALSAFARPETSPPPAATMTDNIHLSINKSTVNQETMQ"
     CDS             7970..8533
                     /locus_tag="ctg23_11"
                     /transl_table=11
                     /translation="MTVPNTIMDDVAKPYRKYDDVVYLIQNKKIVAALSISKFSANQND
                     PRLDKISKSASLILQPENPKVSRQEMEKLKNLLDKKGLTSEINMNIFKIGDAAAPPPPP
                     PAGQVIFSYRDGQPDQQFVLYDRHAKPGANLGQRIDKIYKDNITKVSIKINKSTPKDLL
                     ETVKQELKKKINYPVQYEILQFVD"
     CDS             8645..9880
                     /locus_tag="ctg23_12"
                     /transl_table=11
                     /translation="MIHNVKILFFICFFTACSSTEQKEIVTAGELLRQAAFYGERLQFL
                     PALETYQQAIKLAEKEKDSTVFSLAYLEMGKIYRYQSLKQKALQSEKKALSYIKSPACD
                     SLRLELYREIGDMYTLSGQADSAFHYYEMAGCRIKQAKILQQNGSNKEAETLLKTELEQ
                     TIFSKEKAEVCLALADLQITLGKLDEAEKSLSQVPPSHPHLYAALSRIAQSRGDSLQAD
                     FYHKSYLHHLSVLRQEKEQNQITQLLRTSEQKEWEKRLTDSQKAQKEQIYVWVTLLVSC
                     STGIWGYSRYRQKRNVVSLSETDFFSSEIYLRFHRKEEWKPVPKDWEELLQAFNRTYPD
                     FRERLKRKIPKLSEQEWRMCCLIKMEVPPSTAAMLLCCTNQAISMRRVRLYQKITGEKG
                     TPELCDSFIRDF"
     CDS             9947..11143
                     /locus_tag="ctg23_13"
                     /transl_table=11
                     /translation="MKKMLFGLMTAIATFTGCESKQPAGELPRIDLTATSFAFDQVEIA
                     DEIESIEYVPLELTDESLIADVLDLCVSDEYIFVYSTRQDGVLQFDRKGKFLRCIAKTG
                     NGPGETGQIISLTVDEENRLFCVSEYFSTSFYSFDGEFIKKIENPRPYSYQFSVGPNTM
                     AELGRMYVPMNTPGMFSLGVFNWGTDDTIAFRHTIGDMDLMPLEETSLKGWIFSGSKDG
                     ILCYSEGIDTVWDVNARNIAPAFLINTGYSVEEEKEMRSSKTGNEAVDGKYSVFSFFET
                     PRHYFVKCFEGSNQSKFYLYGLDKATGELKRETSPLNAQELFKNNWTLAGIGFRNTKDN
                     GLPIWPYLSYPGKKQMVQFNTAVEIEYLKEKYPDLKKHLVLQQITEDSNPLITIYHLR"
     CDS             11186..12457
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_U32"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_14"
                     /sec_met_domain="Peptidase_U32 (E-value: 6.4e-69, bitscore:
                     223.6, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKNLNEKDFEIMAPVGSYESLMAAIQGGADSIYFGIEGLNMRSR
                     SSNNFTTDDLRKIVALCREHGIKSYLTVNTVIYGEDLPLMREIIDAAKEAEVSAIIAAD
                     VAAMNYANSIGQEVHLSTQLNISNAEALKFYARFADVVVLARELNLKQVHEIYRQIVDQ
                     QITGPKGELIRIEMFAHGALCMAVSGKCYLSLHEMNASANRGACMQICRRAYSVKDKDS
                     NIELDIENQYIMSPKDLKTIHFMNKMMDAGVRVFKIEGRARGPEYVRLVTECYKEAVRA
                     YCNGTFDEKKVAAWDERLRSVFNRGFWDGYYLGQRLGEWSSKYGSGATKKKVYVAKGIK
                     YFDKIGVAEFEMESGNLKVGDEILITGPTTGAVMQTIEEIRVDLKPVDETVKGERFSLK
                     VNEKIRPSDRLYKMEKVQLEKVFE"
     CDS             12457..12864
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_15"
                     /sec_met_domain="HBT (E-value: 3.8e-08, bitscore: 25.6,
                     seeds: 132, tool: rule-based-clusters)"
                     /sec_met_domain="HBT_2 (E-value: 5.7e-09, bitscore: 28.5,
                     seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYIFKLTDKVRDYECDLQGVVNNSNYQHYMEHTRHEFLESLGE
                     NFGKMHEKGVDGFVSRVEIQYKTSLKSGDSYISCLNAYKKGVKLVFEQDIYRASDNALA
                     TKGIVESVIVENGKLTRGEYFDEMLKRIEHT"
     CDS             12861..13976
                     /locus_tag="ctg23_16"
                     /transl_table=11
                     /translation="MTDKRIYQIGLTMINGVGDILARHLLQALGEAEAVFTEKQQLLGR
                     IPGIGSNIAAEIKRPEILQRAEKELAFIEKNNISCYYLTDTDYPVRLRECPDAPILFYF
                     KGNTNLDATRIISIVGTRNATEYGRELTESLIKDLAKVIPDLLVVSGLAYGIDICAHRN
                     ALYNRLPTVAVLAHGLDRIYPSCHRNTAVEMLESGGLLTDFPSGTEPDRPNFLRRNRIV
                     AGISDCTIVVESAEKGGSLVTADIAFSYGRDVYSFPGRVGDSHSKGCNNLIRQNKAGLI
                     TSADDLLSALCWDIQAGATPVQTELFFAEAETFTSEQNPVLAIMRTRNEIHINELASVL
                     EIPVHQLSMLLFELEINGKVKALPGNLYKLS"
ORIGIN
        1 gcgtcggcag cggcagatgt gtataagcga catctataag agcgtaagat ccgggtgtcg
       61 ggggcggata catgggggtg ttgggtaagt tttattacgt gtttttcatt gatttgtagc
      121 tgtatttaca taaaagagcc ttgtctttga tgatatagga gaacaagccc tttttccttt
      181 tcttgtttac cttgccctgc aaattgtcag tttgttttag tagaaattca atcacgttcg
      241 aaatcggaca gcacttctgc cgtagtagcg ttgatgttct tgtccaatac ataaatgcgg
      301 taagacaggc tcagttcttt accgggttcc aatgtgaatg ccttctgctt ggtcggtgag
      361 aaattccaca tgacgtcacc ggcaggcttg ttgacagttt tgtcccatac gcgtaaaggc
      421 tcaggatagt tcaggttgga aggggaggca acgattagga tacaggcctt ttcgtttccg
      481 gctttccctt ggtagtagca ccaacgggct ctcgaaccgt cagcttcgtc gcgggaaagg
      541 ccttccgagg tgagcatttc ggctgtctga tcgttccagt cttcgcgcgt acggatgcat
      601 atgccgccat aacggtaagc ttccatggtg atcgggctag ggctggcgag gcggatagtg
      661 gtatgatagt cgatgtaata acctggtaag gatgttgtcc cgatgttgat ctccaggcgt
      721 tcgttcattg ctactttttc tgcgggagaa tcggggtaga ccacatggtc cagtgtcgca
      781 acaaaaccgt tgtcggatac gtgttcgaag ttgcggaagc gaactgttcc ttgttttttg
      841 tggagattcc agaaatcgat ctcgtttcct tcgaacgtag ttttcgtcca ggcataccac
      901 aaaccgaaat gatggtaatg gtcggcggga gaacaattgg tcatcacttc gcctcccaat
      961 gtcttcaaag gatggatgaa accgctgcgt ttatagaccg agtcaacgcc aggggctggg
     1021 taaaccgtgg tatagttgta agagaacaac agtttatctc ctatcttata gtctaaggtt
     1081 ttccccgtgt cgacgacgga acaggatgtt tcggaaggct gacaagagcc taagaacaga
     1141 gaaatcaaaa aaacaccaat agaaaaaata gcagttttca taatatgaca attaaataat
     1201 aatcagttat ccggcaagac cttgcctgta tcggctacaa aaaaacgaaa ttttttcatt
     1261 tcgcacaatc cgtttgtgat atctgatgca aataaaacca gccagcaagc agtgttctaa
     1321 ttgatgaaat atttctttaa tcgtttgcgt gatatgggga tttagcatac ctttgcacga
     1381 taataaccat agattggagg aaatttctaa atacaattaa ataacttaaa ttattatctt
     1441 atgtggttac ttaattcttc tatcgggaag aagctgataa tgagtatatc aggtcttttt
     1501 ctcattctgt tcttggtgtt ccacttatgt atgaacattg cggcagtatt ttctggtgaa
     1561 gcgtataacg tgatttgcgg tttgctgggt tctaactggt atgctttgct cggtacattg
     1621 gtgttggctg caggtgtagt cgtgcacttc gtgtatgcta ttatcttgac tctgcagaat
     1681 cgtaaggctc gcggtaacga ccgttatgcc atcaacgctc gtccgaaagg tgttgaatgg
     1741 gcttctcaga acatgtttgt tttgggtgtg atcgttatcc tgttcatggt tctgcacttt
     1801 actcagttct ggtacaacat gatgtttgcc gaactggcag gtattcatgg tgacattcat
     1861 ccgcaggatg gtgcagcgtt tatcaatttc tacttccagg gcaatgttgt gaatacggtg
     1921 ttgtatctga tctggttcgt tgctctgtgg tttcacctga ctcacggttt ctggtctgcg
     1981 attcacacaa ttggctggaa caataccgtt tggttaagcc gttgggaatg tatctctaaa
     2041 tgggttgcca ctattatttg tggcttattc gctgttatca cagttatctt ctacctgaac
     2101 ggtgtaggtg cttaatttcg gatattattt tttcaatttg aaaataaaac attatgactc
     2161 aaatagattc taaaattcct caaggcccgt tggctgagaa gtggacaaat tataaaaatc
     2221 accagaaatt ggtgaatccc gcaaacaaac gtcgtttgga cataattgta gtaggtactg
     2281 gtctggcggg tgcttctgct gctgcctctc tggctgaaat gggattcaat gtattgaatt
     2341 tctgtattca ggactctccc cgtcgtgcac actctatcgc tgcacagggc ggtatcaatg
     2401 cggcaaagaa ttatcagaat gatggtgact cggtttatcg tctgttctac gatacaatca
     2461 aaggtggtga ctaccgtgcc cgcgaagcaa acgtctatcg tctggctgaa gtgtcaaact
     2521 ctattatcga ccagtgcgta gcacagggtg taccattcgc tcgcgaatat ggtggtctgt
     2581 tggataaccg ttcattcggg ggtgctcagg tatcccgtac gttctatgcc cgtggtcaga
     2641 ccggacagca gctgctgttg ggtgcttact ctgcattgag tcgtcagatt ggtttgggaa
     2701 aggtgaagat gtacacacgc catgaaatgc tggatgttgt gaaggttgac ggacgtgctc
     2761 gcggtattat tgcccgtaat ttgattaccg gtaagatcga acgttttgcc gctcacgcag
     2821 tcgttgttgc gacaggtggt tatgtaaata cattcttctt gtctactaac gcgatggcgt
     2881 ctaacggttc tgctgcatgg cagtgctaca agaaaggggc ttactttgct aatccttgta
     2941 tggtgcagat ccacccgact tgtgtgccgg tgaaaggtga cttccagtct aaactgactt
     3001 tgatgtctga atcactgcgt aacgatggtc gcatctgggt tccgaagaaa ctggaagatg
     3061 cgaaggcatt gcaggccgga acaaaaaaag gtaaggatat tcctgaagca gatcgcgact
     3121 actatctgga acgtcgttat ccggcattcg gtaacttggt tcctcgtgat gtggcttcac
     3181 gtgccgctaa agaacgttgt gatgccggtt tcggtgtaaa tagcacgggc ttggctgtat
     3241 tcctggattt ctccgacgct atcaaccgtc tgggtaagga agtagttaaa cagaaatatg
     3301 gtaacctgtt cgatatgtac gaagagatca cgaacgatga tccgtatgaa actccgatga
     3361 tgatttatcc tgcattgcac tactcaatgg gtggtttgtg ggtagactat gaattgatga
     3421 cttctattcc ggggctgttc gcaatcggtg aagctaactt ctctgaccac ggcgctaacc
     3481 gtctgggtgc ttctgctttg atgcagggat tggccgatgg ttactttgta ttgccttata
     3541 ccatccagaa ctatctgtct gaccagatcc aggttccgcg cttcagcact gacctgcctg
     3601 aatttgtgga agcagaaaag gctattaacg cccgtatcgc gaagttgatg aacgtgaagg
     3661 gtaaagaaac agtcgattct atccaccgta agctgggaca tatcatgtgg gaacacgtcg
     3721 gtatggcacg cgacgcggaa ggcttgaaag aagctatcca gatgttgaaa gacctgaaga
     3781 aggaattctg gagcaatgta ttcattccgg gtgaggccaa tagcttgaac gtggaattgg
     3841 acaaggcatt gcgtttggct gactttatcg aaatcggtgc attgatggca cacgatgcgt
     3901 tagaccgcgc agaatcttgt ggtggtcact tccgtacgga acatcagacc gaagaaggcg
     3961 aagctatgcg tcatgacgat aagttcatgt acgtctcttg ttgggaatac cagggcgaag
     4021 acaaagaccc ggttatgctg aaggaagatt tgaactatca gttcgttgtt cctcaaacac
     4081 gtaactacaa gaagtaataa tcatcaatca caaaaattag aatcatggat aaagatataa
     4141 aggtaacact taaagtttgg cgtcagaaag gtccgaaaga taaaggacaa tttgagactt
     4201 accaaatcga caaaatcaat cagagtgttt ctttcttgga aatgttagac attttgaatg
     4261 aacgtttggt tagcgaaggc aaagaaccta tcgtattcga ccacgactgc cgtgaaggta
     4321 tctgcggtat gtgttcattg tatgtaaacg gacatccgca cggaccggca acaggtgcaa
     4381 caacctgtca gctctatatg cgccgtttca atgatggtga gacgattacg atcgagccgt
     4441 ggcgttctgc cggtttcccg gtaatccgcg acttgatggt agaccgttat gcttatgata
     4501 agattatcca ggcaggtggt ttcgtttctg taaacacagg tggggttcct gatgctaatg
     4561 caattcctat ttctaaggct gatgcggatt tggctatgga tgctgctgct tgtatcggct
     4621 gcggtgcttg tgctgctgct tgtaagaacg gttcagctat gctgttcgtc tctgcaaagg
     4681 ttagccagct ggctcttttg cctcagggta aggtggaagc tgctcgtcgt gcaaaagcaa
     4741 tggttgctaa gatggatgaa ctgggctttg gtaactgtac gaacactcgc gcttgcgaaa
     4801 tggaatgtcc gaagaacatc tccgttagca acatcgctcg cttgaaccgc gagttcatct
     4861 ctgctaagtt acaagactaa tacattatat atatatgtat atggaaaagc ccgtcgccaa
     4921 tggcaacggg ctttctttat gttcgttcaa acccacaaaa aagccgcact ccctataata
     4981 aaagtggatg cggctttttt gttgctttcc agtgaaacag tctctcgatt ccctctctgc
     5041 aaagactttg ttaaccttag atctaaaata ctatgaaaaa aactcactgc aaatataaag
     5101 tatatttact gaatacgcaa gagtttgtaa ttacatttta ttgcaaattt gctacttttt
     5161 gttttaaaat tgacactgtg tgcggattca cactgttatt atatcaacaa tcgatcgatt
     5221 ctgacacttg agagtcgctt tgaaatccgt atcctgtatg aaatttgtcg gggatggaat
     5281 ccagaatgtc gaataatgct tccactgttt ccgcacgtag catggcgacg cgtgtctgct
     5341 tgaagtctgc aataccttta aacagcggag ttgcagccaa atggcggcga atgtggagaa
     5401 ttccccggcg ctcatccaaa cgttccacgc tttgttccac ctgctttttc agtatgtcca
     5461 gataccatga aaaagattcg gcaggcaatg tctcgcctgt atccagataa tgcctcactt
     5521 ctctgaaaat ccaggggcgg cctatgctgc cccggccaat cataacggca tccacgccat
     5581 attgttcgaa acgttgtttg cagatttcgg cggaagtcac atcgccattg ccgatgatgg
     5641 gaatttgtat gcggggattg ttttttactt caccgatcag tgtccagtct gcctctcctg
     5701 tgtacatctg tgcccgggta cgtccgtgga tggaaagggc tgcgataccg caatcctgta
     5761 gctgttcggc caagtctacg atgatccggt tgtcggcatc ccagcccaag cgggttttta
     5821 cggtgacagg gatgttcacc gctttgacga cttcacgggt gatgtccagc atcagtggaa
     5881 tattgcgcag catgccggcg cctgctcctt tgcctgccac tcgtttgaca ggacaaccga
     5941 aattgatatc gagaatgtcc ggatgagcag cttcgcaaat ttgcgcggct tcgaccattg
     6001 tcggaacatc acggccatat atctgtatgg cgaccggacg ttcttcatcc gccacgttca
     6061 gcttttgctg tgttttattt acactgcgga tcagggcgtc tgctgaaacg aattcggtat
     6121 aaaccatatc ggcaccaaaa cgtttgcaca tcaaccggaa agaaatatct gtaacgtctt
     6181 ccatcggagc taagaagacg gggcgttcgc ctaaatctat tgtacctatt ttcatattta
     6241 tattatcaat gacggggaca aaggtactga tttcctgcta aaaacaggga taaaaggata
     6301 tctactaaaa aatatagtaa aataactata tgatatagtt gtgttactaa ataatatagt
     6361 tgtatttgtg cattcctcta acaaaaaacg gattatggtt agattaacat caaaagaaga
     6421 agaaatattg ggctactttt gggcgaaagg ccccctgttc gttcgcgaac tactcgactt
     6481 acaggaagaa tctaagccgc attataacac cttgtccacg attgtccgct cattggaaga
     6541 aaaaggatat atcggataca aggtatacgg taatacgcac caatactatg cactggtatc
     6601 ggaagacgaa taccggcgta attccttgaa acaggtgatc agcaaatatt atgacaactc
     6661 gtacacccgt gtcgtttcga cgctgataga agaagaggtg ctcacgatcg acgagttaca
     6721 gaagctgatc cagcagataa aaaacaaata aaaaaccaac gcttatggac gcttttcttc
     6781 tatacatatt aaaatctggt atttgcctga cagtctttta tgtctgtttc aaggcattat
     6841 tcagtaacga cacgtttttc cggttcaacc gctggatatt actggtaggg acaggagttt
     6901 gcatgttgct gccactttgc cggatccaaa cagcccggcc ttttcctctt agccggccag
     6961 tcagccaact ggagatagtt ttctatgaag aagagatgaa agcgtttcct gttccggaaa
     7021 gcaaagaaga aattacgatt ccgacagagc agagaaatat atctgttccc tggacgggaa
     7081 ttatcgggat tgcttttcta acaggcagtg gtatctgcct gaccacaacg attctgtcat
     7141 tcggaaaaat gtatcaacta acaagaaaaa acaggaaact aaaacagggg aaatacacgt
     7201 taatcctgac tcccgatccc atatcccctt tcagttgggg acgttatata ttcctttcgg
     7261 aaaacgatta ccggaaccat ccgaacgaaa tcctcatgca cgaaaaaatg cacctccgct
     7321 ataaccattc ggtcgatctg atctatatga aacgattctt cttctgcaat ggtttaatcc
     7381 tgccgtatgg ttattaaaaa gggaattacg gggcatacac gaataccagg cggataaagg
     7441 cgtactcagt caaggcatcg atgcaacaaa atatcaacta ttactcgtga aaaaagctgt
     7501 cggctccagc ctctacactc ttgccaacag cttcaatcac agtaaaatta aaaaacgtat
     7561 tactatgatg ttaaaaaaga aatcaaacaa ttgggcccgg ttgaagcttg cgctcctggt
     7621 cccggtaggc ttcgcggcct taagtgcatt cgcccgtccg gaaacaagtc cgccgccggc
     7681 agcgacaatg accgacaaca ttcatctatc gattaacaaa agtacggtaa atcaggaaac
     7741 gatgcaatag gatcatgcag ttttcctcac ctacaaagaa tcgggttcgg aggatctgaa
     7801 cagtattgta tgcaaaactc tggacagaat cagaacacga gtagcggagg gacaattcaa
     7861 gaacgccctg gaagttactg ttaatccggc cttcgacgat atcccggctt cttatctgga
     7921 aacagtaaaa gatgttttgg aagaaagaga tattaaatgc aagatcgaca tgactgttcc
     7981 gaatactatc atggatgatg ttgccaaacc ttaccgcaaa tatgacgatg tggtttatct
     8041 gattcagaat aaaaagattg tcgcagcact aagcatcagt aagtttagtg caaaccagaa
     8101 tgatccgagg ctggataaga tatccaaatc agcttcctta attctccaac ctgaaaatcc
     8161 gaaagtatcc agacaagaaa tggagaaatt aaaaaacttg ttggacaaaa aaggattgac
     8221 aagcgaaatc aacatgaata ttttcaagat cggagatgct gcggctccac ctcccccacc
     8281 tcctgccgga caggttattt tcagttaccg ggacgggcag ccggaccaac agttcgtttt
     8341 atacgatcgc catgccaaac cgggagccaa tctcggacaa cgcatagaca agatttacaa
     8401 ggacaatatt acgaaagtaa gtataaagat taacaaaagt actcccaaag acctgttgga
     8461 aacggttaag caagaactga aaaagaaaat caattaccct gtccaatacg agatcctgca
     8521 attcgtcgat taaaatcaga aacacggatt atctatttat catcctctcc gtttacaaaa
     8581 cctgctccag ggggtaaacg gagaggaata ttattatctt tactccttca aaagaaggat
     8641 tcagatgata cacaatgtaa agatactctt tttcatttgc tttttcaccg cctgttcttc
     8701 taccgaacaa aaagagattg tcaccgccgg agagctcctt cgacaggctg ctttctatgg
     8761 ggaaagattg caatttcttc cggcattgga aacctatcaa caggcaatca aattggcgga
     8821 gaaggagaaa gacagcaccg tcttttccct tgcctacctg gaaatgggaa aaatctatcg
     8881 gtatcaatct ttaaaacaaa aggcactaca aagtgagaaa aaagcattaa gctatatcaa
     8941 aagtcctgcc tgcgattcgc tacggctgga actttaccgg gaaatagggg atatgtatac
     9001 cttgtccgga caagcagaca gtgcctttca ctattatgaa atggctggat gtcggataaa
     9061 acaggcaaag atattgcaac agaatggaag caataaagag gctgaaactt tattaaaaac
     9121 ggagttggaa caaacgattt tctcgaaaga gaaagcagaa gtatgtctgg ctttggctga
     9181 tttgcagatt actttgggaa aattggacga agccgaaaag agtttaagtc aggtcccccc
     9241 ttcccacccg catctgtatg ctgccctgtc ccgcatcgcc caaagccgtg gagacagcct
     9301 gcaagctgat ttctaccaca aaagctacct ccatcactta tccgtcctgc gacaggaaaa
     9361 agaacaaaat caaattaccc aactccttcg tacctcggaa cagaaagaat gggaaaaacg
     9421 tttaaccgat agccaaaagg cacaaaaaga acaaatatat gtctgggtca cgctacttgt
     9481 ctcttgcagt accggaatct ggggatattc ccgctaccgg cagaaaagaa atgtcgtttc
     9541 cctgtccgaa acagatttct tttcttcaga aatctacctg cgcttccacc gaaaagaaga
     9601 atggaaaccg gttcccaaag actgggaaga attgttgcaa gctttcaacc ggacctatcc
     9661 ggatttccgg gaacggctga aaaggaaaat accaaagttg agcgaacagg aatggcgcat
     9721 gtgctgcctg atcaaaatgg aagttccccc ttctactgcc gccatgctcc tttgctgcac
     9781 gaaccaggcg atttcgatgc gccgcgtacg cctgtaccag aaaatcacag gtgaaaaggg
     9841 cactcctgag ctgtgtgatt cctttattcg tgatttttaa gcagatgtga actgatgtga
     9901 aaccggggaa atagccgtat cttctacttt tgtctaaaaa aagcgtatga aaaagatgtt
     9961 gttcgggctt atgacagcca ttgccacttt taccggatgc gaatccaaac aacccgccgg
    10021 agaactcccc cggatcgatc tgacagcaac aagttttgct ttcgatcaag tagagattgc
    10081 agacgaaatc gaatccatcg aatatgttcc gttggaacta acggatgaat ccctgatcgc
    10141 agacgtattg gatctgtgtg tttcagacga atatatcttc gtctattcta cccgtcagga
    10201 cggtgtcttg cagttcgacc ggaaagggaa gttcttgcgc tgcatcgcta aaacaggaaa
    10261 cgggccggga gaaaccggac agatcatttc gctaaccgta gacgaagaga accgcctctt
    10321 ctgtgtcagc gaatacttct ccacctcttt ctactccttt gatggagaat ttatcaaaaa
    10381 gatagagaat ccgcgccctt actcgtacca attctctgtt ggcccgaata cgatggcgga
    10441 attagggagg atgtatgttc ccatgaacac gccgggcatg ttcagtctcg gagtctttaa
    10501 ttggggcaca gacgatacga tcgcattccg gcatacgatc ggggatatgg atctgatgcc
    10561 gttggaagaa acgagcctga aaggttggat attcagcggc agtaaggacg gcatactatg
    10621 ctattcggaa gggatagaca cggtctggga tgtaaatgca agaaatatcg ctccggcttt
    10681 tcttatcaac acgggatatt ctgtcgagga agaaaaagaa atgcgctctt ccaaaaccgg
    10741 taatgaggcg gtagacggga aatatagcgt cttcagcttc tttgagacac cccggcatta
    10801 cttcgttaaa tgtttcgaag gttccaacca atccaaattc tatttgtacg gtttggataa
    10861 ggctaccggt gagttgaaac gtgaaacttc tccgcttaat gcccaggaat tattcaaaaa
    10921 caactggacg ctggcaggaa taggcttccg aaatacgaaa gacaacggtc ttcctatctg
    10981 gccttacctg tcttatcccg gcaaaaaaca aatggtacag tttaatacag ccgtggaaat
    11041 cgaatatctc aaagagaaat atcctgatct caagaagcat ctggtcctgc aacagataac
    11101 ggaagattca aatccgctca tcacgattta tcatttgcgc tgatcttctc ggatattatt
    11161 cctacctttg cgaacgaacc agtaaatgta taagaacttg aacgagaaag attttgaaat
    11221 aatggcgcct gtcggttcgt acgaatcact gatggcggct atccaagggg gagccgattc
    11281 tatctatttc ggtatcgaag gattgaatat gcgttcgcgc tcttccaata actttacgac
    11341 agacgatttg cgcaagatcg ttgcgctttg tcgtgagcac ggtattaaga gctatttgac
    11401 cgtcaatacg gttatttatg gggaagacct gcctctgatg cgcgagatta tcgatgcggc
    11461 gaaggaggcg gaagtttcag cgatcattgc ggccgatgtg gcagctatga actatgccaa
    11521 cagcatcgga caggaggtgc atctttccac acagctcaac atttccaatg cggaagcact
    11581 gaaattctat gcccgttttg ctgatgttgt cgtcttggcg cgtgagctga atttgaaaca
    11641 ggtgcatgaa atctatcggc agatcgtcga ccagcagatt acgggaccga aaggagaact
    11701 gatccgtatc gaaatgtttg cccacggagc tctctgtatg gccgtttccg gtaaatgtta
    11761 cctgagcctg cacgaaatga acgcttccgc caaccgggga gcttgcatgc agatttgtcg
    11821 gcgtgcttat tcggtaaaag ataaagacag caatatcgaa ctggatatcg aaaaccagta
    11881 tattatgtcg cctaaagacc ttaagacaat tcatttcatg aataagatga tggatgcagg
    11941 tgtacgggta ttcaagatcg aaggacgtgc ccgcggtcct gaatatgtcc gcctggtgac
    12001 cgaatgctat aaggaagctg tgcgtgccta ttgcaatggc acgttcgatg aaaagaaagt
    12061 tgccgcttgg gacgaacgcc tgcgcagtgt gttcaaccga ggattctggg atggctatta
    12121 tttggggcaa cggttgggtg agtggagtag caaatatggc tccggcgcga ctaagaagaa
    12181 agtgtatgtt gccaaaggaa tcaaatattt cgacaagatc ggcgtggcgg agttcgaaat
    12241 ggaatccggt aacctgaaag tgggtgatga aatcctgatt accggaccga caacgggtgc
    12301 ggttatgcag acgatagaag aaatccgtgt ggacttgaag ccggtggacg agaccgttaa
    12361 aggtgaacgg ttctctctca aggtgaacga gaagattcgg ccgtctgacc gattgtataa
    12421 aatggaaaag gttcaacttg aaaaggtatt tgaataatga aagagtatat ttttaaactg
    12481 acagacaagg tccgtgacta cgaatgcgac ctgcaaggag tggtcaacaa ctccaattat
    12541 cagcattata tggaacatac tcggcatgaa ttcttggagt cgcttggcga gaacttcgga
    12601 aagatgcacg aaaaaggggt tgacggattt gtatcgcggg tagaaatcca gtataagacc
    12661 tcgctcaaga gcggcgacag ctatatctct tgcctcaatg cctataaaaa aggagtcaag
    12721 ctcgtattcg agcaggatat atatagggct tctgacaatg cattggcgac gaaaggaatc
    12781 gtcgagtcgg ttatcgttga gaacggaaag ttgacacgcg gtgaatattt cgacgaaatg
    12841 ctaaaaagaa tagaacatac atgactgaca aacggattta ccaaatcggc cttactatga
    12901 taaacggcgt gggagatatc ctggcgcgtc atctcctgca ggctttggga gaagcagagg
    12961 ctgtgtttac tgaaaagcaa cagttgttag gaaggatccc tggtatcggc agcaatattg
    13021 ctgccgaaat caaacgcccg gaaatcttgc aacgggcgga aaaagagttg gcttttatcg
    13081 agaaaaacaa tatttcctgt tattatctga ctgatacaga ttatccggtg cgcttgagag
    13141 aatgtccgga tgcccctata cttttctatt ttaagggaaa tactaacctt gatgcgaccc
    13201 gtatcatcag tattgtgggt actcgcaacg cgaccgaata tggtcgggag cttaccgaat
    13261 cccttataaa agacttggca aaagtgatcc cggacttgtt ggtcgtgagt ggattggctt
    13321 acggcatcga tatctgtgct caccggaacg ctttgtacaa ccgacttccg actgttgctg
    13381 tgctggcgca tggcttggat cgtatctatc cttcctgcca tcggaatacg gctgtcgaaa
    13441 tgctggaatc gggcggtctg ttgaccgatt ttcccagcgg tacagaacca gaccgtccaa
    13501 atttcctccg gaggaaccgg attgtcgccg gaatctcgga ttgtacgatc gtggttgaat
    13561 cggcagaaaa aggaggctct ttggtaactg ccgatattgc attctcttat ggccgggatg
    13621 tctatagctt tccagggcgt gtcggtgaca gccattccaa aggatgcaac aatttgatcc
    13681 gacaaaataa agccggcctg atcacttctg cggacgatct gctctccgct ctttgttggg
    13741 atatccaagc tggggctact cccgttcaaa cggagttgtt tttcgccgaa gcggaaacat
    13801 tcacctcgga acaaaatccg gttttagcca ttatgcgaac gcggaatgag attcatatca
    13861 acgagcttgc ctcagtgttg gagataccgg tacatcaact ctctatgcta ttgttcgaac
    13921 tggaaataaa cgggaaggta aaagcgctgc cgggaaatct ctataagctg tcctgaccgg
    13981 ctttttcgta tacgatttgt atgtgggaga agaaacggaa cctctataaa caattaaagg
    14041 ctgtctcacg acaaccccta accaactttg ttaaccttaa atctaatact attatgaaaa
    14101 aaccacattg caaagataca ctcgtcaaga gcgtttgtca agcattttgt cgctaatact
    14161 tgttaatcag atgggcataa atagcaaaaa gattttaatc ggctataaag agtcctttaa
    14221 actgcgctat tttgttaaat cgagtccttg aaacaggtac ggatagtccg tttcgatcac
    14281 gtcgggacga gtgctgatct ctgaccggta accggcggtt ttctctgttt ccgttttcgc
    14341 gcgatcatgt gtcggagcaa cggaaatcat gcacatgact ccgttacggt gcagagcgtc
    14401 atacagtggt tgctgttcag gcttcatctt cgggcctaca taagccatta cctgtttcca
    14461 ggggatgccg gctttttcat aattatcgaa ttcttcccga ttcttacacc agcaagaaaa
    14521 catcgcatcc ggtttccggt cgagataata gcgggcttga ctggcgttat gtaccgtgta
    14581 catgacgtta acaggctttt ctgtttctat aaaatcagcc ataacttcta aaggtacatc
    14641 cttgatatcc aaattcagga ttgttttgcc tttgctccat tccaggcatt cttttaaagt
    14701 tggaattttg aaggctgtca cgttgccgtt tcggtccacc agattgaatt gttgcagttc
    14761 tgcataagtg taatctgaaa cctttccttt cccggtagtt gtccggtcga tggtttcgtc
    14821 gtgcatcaat acgattatcc cgtcttttgt caaacgcgga tctatctcga aaaacgattc
//
