LOCUS       c00019_gnlPro..        14037 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JBGAHFHO_19.
ACCESSION   c00019_gnlPro..
VERSION     c00019_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:58:45
            Original ID  :: gnl|Prokka|JBGAHFHO_19
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14037
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..477)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_1"
                     /sec_met_domain="HMGL-like (E-value: 2.3e-18, bitscore:
                     57.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDACLRFLKEDPWERLRKLRDGFKNTKLQMLFRGQNILGYKPYPDDVVE
                     YFVQKSIANGIDVIRIFDCLNDLRNLQTAVDATKKEGGHAQIALSYTIGDAYTLD"
     protocluster    1..14037
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:4037]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..4037
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14037
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14037
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(635..1759)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_2"
                     /sec_met_domain="OAD_beta (E-value: 1.7e-157, bitscore:
                     514.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVST
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGAEA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             complement(1793..2161)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.6; E-value:
                     4.3e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.3e-21, bitscore:
                     66.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEESAAPVSTPAAVPAPAKKAAP
                     KTSGSAGAVKITAPMPGKIVAVKAQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             complement(2256..2600)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_4"
                     /sec_met_domain="OAD_gamma (E-value: 8.6e-28, bitscore:
                     87.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSADKLV
                     VRSIKRVKRR"
     CDS             complement(2613..4037)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_5"
                     /sec_met_domain="CT_Vparvula (E-value: 1.9e-137, bitscore:
                     449.1, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNSKMNARERIDYLFDDHSFVEVGGYVSARNTDYNLGAKKVEGD
                     GVITGYGVINDRMVYVYSQDASALGGSVGEMHAKKIASLYDLAMKTGAPIIGMLDCAGL
                     RLQEATDALHAFGTIFNKQAQASGMIPQISAVFGMCGGGSAVMSAMSDFTLMEKENGSL
                     FINSPNALAGNEESRQNTAGAQFQSEQAGNVDFVCETEEGLLDQLRILVDVLPSDYEAE
                     YVYFDNDDDLNRVIPELNDAAYDAAYILKSISDNNMYIETKAAYAKEMVTAFIRLNGET
                     VGAVANQPVDGESVLTRNGLEKAERFIKFCDAFSIPLLTVTNVTGLRANAHEERKQALA
                     LAKFTTTLAQVSVPRINLIAGEAYGTAAEVMNSKAIGADFVLAWPQASVGMMDAEQAVR
                     IMYAEEINTDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRKRLIAAYEM
                     LYGKKVTPVTKKHTAV"
     CDS             4760..5401
                     /locus_tag="ctg19_6"
                     /transl_table=11
                     /translation="MENRKIQFRSKACNLHLSAYPGHFATKHSHVNYFLDMTTLKVRQS
                     NAEEAARALVPLYKHNTVVDTIVCLDGTEVIGAFLAEKLTESGFFSYNQHKSIYIVTPE
                     IDSDGQMFFRKNIQPMIKDRNIIILMASVTTGITINRSWECIEYYGGKLQGISAIFSTL
                     SEYGNLPVNALFTPNDIPTYHTYDKHDCPYCKSGQKIDALVNGHGYSELL"
     CDS             complement(5535..6548)
                     /locus_tag="ctg19_7"
                     /transl_table=11
                     /translation="MQKIPECRSMNFSIYEGMLNRYKDSEDIRKSYESRGLNGLEVIRA
                     GEPDEGKILPDMVNGVHLYFHIFWMDWWKGNYERLDQEFDSREQWLEYFGGMSRESYLN
                     SLRDDLAYAEQVGAKYVVFHVSEVTLRESYIYKYRYTDKEVIDASLEVINTLLDEKEYP
                     FDFLVENLWWSGLTLKNVRLTRRLIEGMHTQKKGIMLDTGHYMNTTTQLKTPEDAVAYL
                     NKMIDKYEKAQMLHWFKGMHLQLSLGGDYVRKQRKEWREHPIDFDKIPFYELFRLAYDH
                     ACHIDLHQPFIGEGVREFVERVAPKYITLEYQQNSREEYEQFVETQSKILKWITIH"
     CDS             complement(6685..7659)
                     /locus_tag="ctg19_8"
                     /transl_table=11
                     /translation="MADWKSSQEFLKEFYASPIVNEDTIPAKIKRIFLPKSRKVSALKE
                     LAGDLSGEGRAGDVILDNDMFEMDTEIWKKQEKRRLSVRTRVSLFLLLVAIPLTIAVGF
                     YVMDVAAVGTVFEKIFGPRKYYFISLVIIIYSLLPFFMVFEGRKPQVRELVVLATMVAL
                     ATAGRAAFFMIPSFKPIIAIVIISAIAFGGEAGFLVGAMTMVVSNFLFGQGPWTPWQMF
                     AMGFIGFLSGILYRIGLLPTKRLSLCIYGFLVTVFIYGGIMNPAALFMSVYDFTWEGLL
                     AIYISGIPVDLVHASSTFIFLWIGAKPLLEKLQRIKIKYDLMR"
     CDS             complement(7663..9456)
                     /locus_tag="ctg19_9"
                     /transl_table=11
                     /translation="VTANGLSEKKNSILEINDLCFAYPEEKKRALNHVSLQVEDGEFLV
                     LCGKSGCGKSTLLTHLKTPLTPHGKRKGEILFQGVSIGEMSNWEQSQRIGYVLQNPDNQ
                     IVTDKVWHELAFGLESLGYSNADIRIRVAEMASYFGIQDWFYKNVSELSGGQKQLLNLA
                     SIMAMHPDMLILDEPTSQLDPIAASDFLETVKKINRDLGTTIILTEHRLEEVFPSADRV
                     VVMDEGQILCVGTPSEIGEELKKRNHEMFLAMPVPMQVYAKVESEQPCPITVRDGRKWL
                     DIVCKKKGISPANASSSYRKKSDSQKGKSSFSKITEKFKEKFKEKKEDIILACDDLWFR
                     YDKELPDVVKGLSFSLKRGEFFALLGENGTGKTTTLSLLSRLRKPYRGKVLLEGKDIRR
                     YSNKELFRNFLGVLPQNPQSLFVKKSVELELFEMVGGVKEKKDEEYQLAMDKKDAVEGI
                     IKVTHLEELLHRHPYDLSGGEQQRLALAKILLLRPKLLLMDEPTKGLDSYFKKEFAGIL
                     ALLKEQGVTVFMISHDIEFCASYADRCGLFFDGNIVACGTPGEFFAGNNFYTTAANRMA
                     RRYFPMAVTEEDVVECLKKGV"
     CDS             complement(9498..10439)
                     /locus_tag="ctg19_10"
                     /transl_table=11
                     /translation="MKDTFSTYHPVLNMLYFCGTIGVTMFVVHPVILAISFICAVAYSV
                     VLKGWKKTVKFNLLFSLPMMIIVALINPMFNHYGVTIIGYLHNGNPFTLESCVYGLVMA
                     VMLVCTLVWFSCYTVVMTSDKFIYLFGRIIPALSLVLSMCLRFVPKFIKEASVISDGQK
                     CVGRSVENGSLIKRAKHGITIFSILVTWSLENAIETSDSMKCRGYGEKGRTAFSLYHFD
                     KRDFLCLIFMIITFGAAMWGFSKGYAFCSYNPRIVVKGVPFTAGSLLVFAAFLLFSIMP
                     AAMEILDRRMWKARRGQVESAAPAGYRLWEVE"
     CDS             complement(10516..11790)
                     /locus_tag="ctg19_11"
                     /transl_table=11
                     /translation="MKKKGFMRVVLALLMSMLLIVSTGCGKSGNGGSSSGKKSGKTATL
                     ADMNEIPEDGIITKEQFKTVAGDNKKVQFKGTTDDGITYIWTYDCSKIQNPADQNLKID
                     FSEKGLDDLKKQANNANDALKMTMYGKGLICVPDLEVQLPEAWQSNSAYLVKEQAGKLA
                     RMSDVVVTAQAEEDSSKKKDTSASQKDSSDKVKEATTAAKKDTKPQKGTTSLKMSVTSL
                     DGDCYIIGGITEQQNKGASAANKAENGTTNSESEGSSGSGDVSDGGASSSGSSGKQDVA
                     NDEEVSGSSHTCTISISCATILNNMSDLKSGKEEFVPSDGWILAASEVEFTEGESVHDV
                     LQRVCKDAGIQMESSFTPAYNSAYVEGINNLYEFDCGQLSGWMYNVNGWFPNYGCSKYT
                     VQDGDVINWVYTCNLGKDVGDNSMY"
ORIGIN
        1 gtctaatgta tatgcatcac cgattgtata ggaaagggca atctgcgcgt gtccgccctc
       61 tttctttgtt gcatctacag cagtctgtaa gtttctaagg tcatttaaac agtcaaaaat
      121 acgaataaca tcaattccgt ttgcaataga tttctgtacg aaatattcta caacatcgtc
      181 tggatatggc ttatatccta agatgttctg tccacggaat aacatctgta actttgtatt
      241 cttaaagcca tctcttaatt tacgaagtct ctcccatggg tcttccttta agaaacgcag
      301 gcaggcgtca aaggttgcac cgccccagca ttctactgca tgataaccaa cctgatccat
      361 cttatctacg attggcagca tctcctctgt tgtcattctt gtagcaatca gagactgatg
      421 tgcgtcacgg agaacggttt ctactatttt aaccggtttt ttcttaattt cggccataat
      481 atctcctttt atttcaaatc acgtaactat ttgcgcttac aactgttatt atctaaaatt
      541 caatttgtaa actatttata aatatcccct gtaacatttt ttacagatta tagccctata
      601 aataatgaat tttaaataat caaataattc taaattatac tccaaaaatt gccataaatg
      661 ttccggcggc taccgctgta ccgataactc cggcaacgtt tggtcccatc gcatgcatca
      721 gtaagaagtt tgatggatct gcttccgcac caactttctg ggatacacgg gctgccatag
      781 gaacggcaga taccccggca gaaccaatta atggatttac cttaccacct gtaaccttac
      841 acataagttt accaaacagg acacctgctg cagtaccaac agcaaaagct acaagaccta
      901 atactacaat cttgattgtg ctgacattta agaatgcctc tgcacttgtt gtcgcaccaa
      961 cggatgtacc aagaataata actacgatgt acataagagc gttagacgct gtctctgaaa
     1021 gctgttttac tacaccagat tctctgaaaa gattaccaag catcagcata ccaactaatg
     1081 gcgctgttgt aggaagaatc agacatacaa caactgttac aacgataggg aacataattt
     1141 tctctgtttt tgtaacggtt cttaactgtt ccatcttaat ctgacgttcc ttttctgtag
     1201 taaggagttt catgatcggt ggctgaataa ttggtacaag tgacatataa gaatatgccg
     1261 ctaccgcaat tggtcccatt aagtctgtct gcccaagctt tccggcaagg aaaatagaag
     1321 taggaccatc ggctccacca ataatggaaa ttgctgctgc tgcctttccg ttaaatccca
     1381 taagcattgc aaggaaatac gcgctgtaaa taccaaactg cgccgcagct cctagcaaga
     1441 aacttgctgg attggcaatc agcggaccga agtctgttag tgctccaacg cctaagaaaa
     1501 tcagtgaagg gagaatactc cattcatcta ataagtaaaa ataatgtaat aatccgcctt
     1561 cttccataat ggacggatat aagttaacca gcagcatacc aaaagaaatc ggcactaaca
     1621 aaagtggctc atatcctttg gcgatggcca gatataagaa gactaaagca accagtatca
     1681 taatgaagtt acctggcttt aagaatgcaa atccggtctg tgctgcgaga ttcgtcattg
     1741 tctctacaac ataactcata aatcttcctc cgttttattt tgcaaatatg ctctagttca
     1801 ttgtagccag tacatctccg ccttctacca tatctccaac tgctacttcc acacttgcga
     1861 taacaccatc ctgtgctgca cagatttcat tctccatctt catagcctct aatacaagaa
     1921 cagcgtcgcc cttctttaca gaagcacctg cctgtgcctt tactgctacg atcttacctg
     1981 gcattggtgc tgtaatcttt acggcaccgg cacttccgga agtctttggg gcagctttct
     2041 tagctggagc cggaacggct gctggtgtac ttaccggcgc tgcactttct tctcctgcac
     2101 ctaattcttc tactgctaca tcataagcaa caccattaac tgtaattcta taatttttca
     2161 ttgtaaatcc tcctgaatga ttttatgtac ttctaaaatc tttctatagc taacttttca
     2221 aaactttata aaaagattcc aagaatacat ttttgctatc ttctcttcac tctcttgatt
     2281 gaacgaacga ccaacttatc tgcactgact gctgctcctc cattcgctgc catgattgcc
     2341 gctgtgatta ctgcgacaag ttcaccatca tccacaagtt cctcttcttc cacaacttct
     2401 tcaagaatcg gacgctttgg agccggtctt tcttcctgcg cagccttttt ctctttctta
     2461 gaagaacgat tctttaacgc tctttcaata gatgggatat atacaaaaag agaaatcagt
     2521 aaagaaatga aaatcagtac tgcaaataca gttcccatac ccatcaaagt atttaataag
     2581 gcttgttcaa atacgttcat actctcacct cactatactg ccgtatgctt ctttgtcact
     2641 ggagttactt tctttccgta aagcatttca taagcagcga taagacgctt tcttgttgcg
     2701 tccggctcga tgatgtcatc tatatatcct ctctttgcag ctgctaatgc actgctctgt
     2761 ccttctgcat attccgcagt tttctctgcg ataagtgctg tcttattctt atctgtattg
     2821 atttcctctg catacatgat acgaactgcc tgttctgcat ccatcattcc tacagatgcc
     2881 tgtggccatg ccagaacaaa gtcagctccg atagctttag aattcattac ttccgctgca
     2941 gttccataag cctcgcctgc aatgagatta atacgaggta cactaacctg tgcaagtgtt
     3001 gttgtaaact tcgctaatgc gagcgcctgc tttctctctt catgtgcgtt ggcacgaagt
     3061 cctgtcacgt tcgttacagt aagaagagga atcgaaaatg catcacagaa cttaataaat
     3121 ctttctgctt tttcaagacc atttcttgtt aaaacggact caccatctac tggctggtta
     3181 gcaaccgcac ctactgtctc tccattcaga cggataaatg ccgtcaccat ctctttggca
     3241 taggctgcct ttgtctctat gtacatattg ttgtcagaaa tagattttaa aatgtaagcg
     3301 gcatcatatg cggcatcatt taactcagga ataaccctat ttaaatcatc atcgttatca
     3361 aaataaacat attctgcttc ataatcagaa ggaagtacat caacgagaat acgaagctgg
     3421 tcaagaagtc cttcttctgt ctcacataca aaatctacgt taccagcctg ctcagactgg
     3481 aactgtgctc ctgccgtatt ctgacgggat tcttcattcc ccgctaatgc attcggactg
     3541 ttgataaaga gactgccgtt ctccttctcc atcaatgtaa aatcagacat agcggacatt
     3601 acggcacttc ctcctccaca cattccaaat actgcagaaa tctgtggaat cattccagat
     3661 gcctgtgcct gcttattaaa aatcgttcca aaagcgtgaa gggcatctgt cgcttcctgt
     3721 aatctaagtc ctgcacaatc cagcattcca atgattggcg cacctgtttt catcgccaga
     3781 tcataaaggg aagcaatttt cttcgcatgc atctcaccta cggaacctcc aagtgcggaa
     3841 gcatcctgac tgtaaacata aaccatgcgg tcattaataa ctccgtatcc agtgataaca
     3901 ccatcacctt ctactttctt tgcaccgaga ttataatcgg tattacgagc ggaaacatat
     3961 ccaccaactt ccacaaaact gtggtcatca aacagataat caatgcgctc tctggcattc
     4021 atttttgaat tacccatatt ctttcctcca taaaaatgct atattgtata ccttgttgct
     4081 ctttcattct atgtaataat aacaaattat tatcatgtta gcaaccattt tctgttagtt
     4141 atttaacatt tattttattt tgcccattcc actaaacaaa atgaacattc tgcctatttg
     4201 caaatttttt aacaattctt tcaattttct ttctgaatct cctgtttttt tcaggaatgc
     4261 ttgtgtattt ttcctgtttt tctctatttt atctttaaaa ttctattttt gttttatatg
     4321 tccattttta tttcgttata attttaacgt attttgacat tcaattacta gttggttttt
     4381 ctattttttc gtcattttat ataaaatatt ctcattctat caaatatctt ccgtttttct
     4441 tcataatttc actcttattt ccatcattct tcttctctcg cttatattct cctcctgtct
     4501 tttttaaatc aaagatatag tatccaaaat caattttggg ctatttttgt caaacttttt
     4561 tcacaaacta atagcgctcc ctttcgtttt atacaactgt atatgcatac cacgaagtat
     4621 tttcaaaaaa tcagaaagaa attataaact gtcaagaaaa gcctgtaatt ttgcacaaat
     4681 actcctttat tttttcacac aaaaaaggta taataaacaa aataaacaat tctttcacaa
     4741 taaaggagga ggacatctta tggaaaaccg caaaattcaa tttcgttcaa aagcctgtaa
     4801 tctacatctt tctgcctatc cgggacattt cgcaacaaag cattctcatg tcaactactt
     4861 tttagatatg acaacattaa aagtacgtca gtctaatgca gaagaagctg caagagcgtt
     4921 agttccactt tataaacata ataccgtcgt cgataccatc gtatgtcttg acggaacaga
     4981 agtaatcggt gcatttttag cagaaaagct tacagagagc ggattcttct cttacaacca
     5041 gcataaatct atctatattg ttactccaga aatagattca gatggtcaga tgttcttccg
     5101 caaaaacatc cagccaatga ttaaagatag aaatatcatt attttaatgg catctgtcac
     5161 aactggaatc acaatcaacc gaagctggga atgtatcgag tactatggtg gcaaactgca
     5221 gggaatttca gcaatattta gtacgctttc tgaatatggt aatcttcctg ttaatgcgct
     5281 gtttactcca aatgatattc ctacttacca tacatatgat aagcatgact gcccatattg
     5341 taagagtggt cagaaaatcg atgctttggt aaacggacat ggatattccg aattactata
     5401 actactaatt tgtagatttc gtatagacga aaaagagaaa ccataccata tcccagatgc
     5461 ggatgagcat tttaaacaca acgactacag agcagatggg atatggtatg gtttcttttt
     5521 tcgtctgttt tctcttaatg aatcgtaatc catttcaaaa ttttactttg ggtttctacg
     5581 aattgttcat attcttcccg gctgttttgc tgatattcca gcgtgatata ctttggtgct
     5641 acgcgctcta caaattcccg gacaccttct ccgataaaag gctgatgcag atcaatatga
     5701 caggcatggt catatgcaag gcgaaatagt tcataaaatg gaatcttatc aaagtctatc
     5761 ggatgttctc tccattcttt tcgctgtttt cttacataat cccctccaag tgacagctgc
     5821 aggtgcattc ctttaaacca gtggagcatc tgtgcttttt cgtatttgtc tatcatttta
     5881 ttcagatatg ctacggcatc ttctggagtc tttagctgtg ttgttgtatt catataatgt
     5941 ccggtatcga gcatgattcc ctttttttgt gtatgcattc cttctataag ccggcgggta
     6001 aggcggacat ttttcaaggt aagcccgctc caccagagat tctctacaag aaagtcgaat
     6061 ggatattctt tttcatcaag tagggtattg ataacctcta agcttgcatc aatcacttct
     6121 ttatctgtat agcggtattt ataaatatag ctctcccgga gtgtcacttc tgaaacatgg
     6181 aaaactacat actttgctcc aacttgttct gcataggcaa gatcgtcccg caaactgttc
     6241 agataagatt ccctgctcat tcctccaaag tattccagcc actgctctct tgaatcaaat
     6301 tcctgatcta ggcgttcata attccccttc caccagtcca tccagaaaat atgaaaatac
     6361 agatgtaccc cattcaccat atccggcaga atctttcctt catctggctc gcctgcccga
     6421 atcacttcca gtccatttaa tcctcgtgac tcataagact ttctaatatc ttcactatct
     6481 ttataacgat ttagcatccc ttcataaatt gaaaaattca tggaacgaca ttctggtatt
     6541 ttctgcatag tttccccctt caatctcgta tactctcaga atcttcctaa gaatacattt
     6601 tatctatact tatcatccat acttatttca aaaatgcccc atcattctgg caatctttct
     6661 aaagttcaaa aacgccccgg ctattcatct catcagatca tattttattt ttatccgctg
     6721 cagcttttcc aacaatggct ttgctccaat ccacagaaaa ataaatgtag aactggcatg
     6781 aacaagatct accggaatac ctgaaatata gattgcaagc agtccttccc atgtaaaatc
     6841 atacacactc ataaagagag ccgctggatt catgattcct ccataaatga acaccgtcac
     6901 aaggaatcca tatatacaaa ggctgagccg tttggtcgga agcagtccta ttcggtaaag
     6961 gattcctgac aaaaatccga taaaacccat cgcaaacatc tgccatgggg tccatggtcc
     7021 ctgcccaaat aagaaattgc tgactaccat cgtcatggca ccaactaaga atcctgcctc
     7081 gccaccaaat gcgattgcac tgatgatcac gattgctata atcggcttaa agctcggtat
     7141 cataaaaaat gctgcccggc cggcggttgc caatgctacc attgttgcaa gaacaactag
     7201 ctctctcacc tgaggttttc gtccctcaaa taccataaaa aacggtaata acgagtatat
     7261 aatgattacc aggctaataa aataatactt tcttggacca aaaatctttt caaatactgt
     7321 gccaacggcg gcaacatcca taacataaaa tccgacagca attgtgaggg gaatcgctac
     7381 aagcaagaga aagagactta ctctggtacg aacagaaagc ctgcgttttt cctgcttttt
     7441 ccagatttcg gtatccatct caaacatatc attatctaaa atgacatctc ccgccctgcc
     7501 ttctcctgac aaatctcctg ctaattcttt taaagcagaa actttcctgc tttttggtaa
     7561 aaagatacgc tttatctttg caggaatcgt atcttcattc acaatcggag aagcgtaaaa
     7621 ttctttcagg aactcctgac ttgatttcca gtctgccatt gttcacactc cttttttaag
     7681 acattccaca acgtcctcct cggtaaccgc catgggaaaa taccttctag ccattcggtt
     7741 tgccgctgtt gtataaaaat tatttccggc aaagaattct cccggagttc cacatgccac
     7801 aatatttcca tcaaaaaata aaccacatcg gtctgcataa gaagcgcaga actcaatatc
     7861 atgagaaatc ataaaaacag ttacgccctg ctctttgagt aatgccagta ttccggcaaa
     7921 ttctttttta aaatagctgt caagtccttt ggtcggttca tccattaaca aaagctttgg
     7981 ccgcaataac aaaatcttag ccagggcaag cctctgctgc tctcccccgc ttaagtcata
     8041 cggatgacga tgcagtaatt cttccaaatg tgttacctta atgattcctt ccaccgcatc
     8101 ctttttatcc atggcaagct gatattcttc atcctttttc tcttttacac cgcctaccat
     8161 ttcaaacagt tctaattcca cacttttctt tacaaaaaga gactgtgggt tttgcggcag
     8221 tactccaaga aaattgcgga acagttcttt attgctgtaa cgacggatat ccttaccttc
     8281 taaaagtact tttccacgat atggctttct caaacggctc aaaagtgaaa gtgttgttgt
     8341 cttcccggtt ccattttctc caagcaatgc aaagaattct cctcttttta aggaaaagct
     8401 tagtcccttt acgacatccg gcagttcttt atcatagcgg aaccacagat catcacacgc
     8461 taagatgata tcttcttttt tctctttaaa cttttcttta aacttttctg taatcttaga
     8521 aaaagaagat tttccttttt gggaatcact cttttttcta tatgaagaag atgcatttgc
     8581 tggtgaaatg ccttttttct tacaaactat gtccagccac tttcgcccgt cacgaacagt
     8641 aatcgggcag ggctgctctg actctacttt ggcataaacc tgcatcggta ccggcatagc
     8701 taaaaacatc tcatgattgc gcttctttaa ttcttctccg atttccgacg gtgtgccaac
     8761 acataaaatc tgcccttcat ccatgaccac taccctgtca gcagaaggaa atacttcctc
     8821 taaacgatgt tccgtaagaa taattgtcgt tccaagatca cgattaatct tctttactgt
     8881 ttccaaaaaa tcagaagctg caatcggatc aagctgagag gtcggctcat caagaatcag
     8941 catatccgga tgcatggcca tgatagatgc cagattcaaa agctgtttct gtcctccaga
     9001 aagttccgat acatttttat aaaaccagtc ctgaatccca aaataacttg ccatttccgc
     9061 tacccggata cggatatctg cgttactgta tccaaggctt tccaaaccaa atgccagctc
     9121 atgccacact ttatctgtca cgatctgatt atccggattc tgtaatacat agccaatcct
     9181 ctgactctgc tcccagttac tcatctcccc gattgatact ccctgaaaaa gaatctctcc
     9241 ttttcgcttt ccatgtggcg ttaggggggt ctttaaatgt gtcagaagtg tactctttcc
     9301 acatccactc tttccgcaaa gaacaaggaa ttccccgtcc tccacctgca aagaaacatg
     9361 atttagcgcc ctcttttttt cttctggata agcaaaacac aaatcattga tttctaatat
     9421 actatttttc ttttctgaca aaccattcgc tgtcaccctg cacctccaaa cttgcttttt
     9481 atctcctgta tatacggcta ttcaacttcc cacaaacggt acccagccgg tgctgcactt
     9541 tctacctgtc ctcttctcgc cttccacatc cttcggtcta aaatctccat cgctgctggc
     9601 atgatactaa acaataaaaa agcggcaaag acaagcaggc tgcctgctgt aaagggtact
     9661 ccctttacaa cgatccgagg attataagaa caaaatgcat acccctttga aaagccccac
     9721 atcgctgctc cgaatgtaat gatcataaaa ataaggcaca aaaaatccct tttatcgaaa
     9781 tgatataagg aaaaggcggt tctgcccttc tctccatatc cccggcactt cattgaatcc
     9841 gatgtttcaa tcgcattctc caaagaccag gtaaccagaa tcgaaaaaat tgtaattcca
     9901 tgctttgctc tcttaataag gctcccattc tctacacttc gcccgacaca cttttgccca
     9961 tcagaaataa cagatgcttc tttgataaac ttcggtacaa agcgaaggca catggaaagt
    10021 actaaagaaa gtgccgggat gatccttcca aaaagataaa taaacttatc tgatgtcata
    10081 acaactgtgt agcaggaaaa ccatacaaga gtacatacca gcatcactgc catcacaaga
    10141 ccgtacacac aactttctaa tgtaaacgga tttccattat gaagatatcc tataatcgtt
    10201 actccataat gattaaacat cggattaatt agggcaacaa tgatcatcat tggtaatgag
    10261 aagagcagat taaactttac tgtctttttc catcctttta aaacaacgga atacgcaaca
    10321 gcgcatataa atgaaattgc cagaatcaca ggatgaacaa caaacatcgt caccccgatc
    10381 gttccgcaaa aatacagcat atttaaaaca ggatgatatg tcgaaaatgt atctttcatc
    10441 taaatcaaat ctccattaca tcaaatttct attatattaa atctttatta tatcaaatct
    10501 ctatttcata catccttaat acatcgaatt atctccaaca tccttaccaa gattacatgt
    10561 ataaacccag ttgatcacat cgccgtcctg taccgtatac ttactgcatc cgtagttagg
    10621 aaaccagcca tttacgttat acatccatcc ggaaagctgt ccgcagtcga attcatacag
    10681 attattaatt ccttccacat aagctgaatt ataagccggt gtaaaagaag actccatctg
    10741 gattcctgca tccttacata cacgctgtaa tacgtcatgt acagactctc cttccgtaaa
    10801 ttctacctcg gaagctgcca gaatccatcc atcagaagga acaaattctt ccttgccact
    10861 ttttaaatca ctcatgttat taagaatcgt cgcgcagctg atcgaaatcg tacacgtatg
    10921 ggaagaacct gaaacttctt catcgtttgc aacatcctgc ttgccggaag aaccagaaga
    10981 agaagctcct ccatcagaaa catctccact tcctgaactt ccttccgatt cactgttcgt
    11041 tgttccgttt tctgccttat tcgctgcgct tgctccttta ttttgctgtt ctgtaatacc
    11101 tccgataata taacaatctc cgtccagaga agttacgctc atttttaaag aagtggttcc
    11161 tttctgtggc tttgtatcct ttttggcagc agtcgttgct tccttcacct tatcagacga
    11221 atccttctgt gatgcagatg tatccttttt cttggaagaa tcctcttctg cctgtgctgt
    11281 taccacaaca tcgctcatcc ttgcaagctt tccagcctgt tcctttacaa gataagcaga
    11341 attcgactgc cacgcttccg gaagctgtac ctctaaatct ggtacacaaa tcagcccttt
    11401 cccgtacatt gtcatcttca atgcatcatt tgcattgttt gcctgcttct ttaaatcatc
    11461 aagacctttc tctgaaaaat caatcttcaa attctgatct gctggattct gaatctttga
    11521 acagtcatac gtccagatat atgtaattcc atcatctgtt gtccctttaa actgtacctt
    11581 tttattgtct cctgcaacgg tcttaaactg ttccttcgta ataattccat cctccggaat
    11641 ctcattcata tccgcaagtg ttgctgtctt gccggacttt ttaccggaag aacttcctcc
    11701 attaccggac tttccacaac cggttgaaac aatcaataac atactcataa gcagtgccag
    11761 aacgacacgc ataaatccct ttttcttcat aaatactttt tccctttctt tgtatatcct
    11821 tagctttaac tctgctcact atacccctta tttttcttta aaaaacagat tatcttttta
    11881 atctattctt tatctccgcc tttttgaaaa ttgcgtaatg aacttgcaat cctatgacgc
    11941 tttttatata aaatgaaagc aataatcact accactgcaa tagcgcaaat ccttttgact
    12001 atataaaata tccctaaaac agccacaatc tttgaggtat cattatcctt ttcggctgtg
    12061 gtgtccgctt ccgctgcatc tgtctcatcc gccgcataag tatccggtac gtaatcctct
    12121 ccgctaaagt tccagcttcc tgtcgttgcc tctgctgccg tatctttctt cttcgctgtc
    12181 gttcctgttg cactctttga cgcagtactt cccgtacctg taccggaagt gcttccggaa
    12241 gaaagtgtct ttgtcgttcc cgaagcggtt ggtgttccac ttcctgtact tactgaacga
    12301 ttcgttgttc ccgatgtcgg tgttgtaatt ctttttgtct gacttcttgc tgctgtagtt
    12361 gttgttgtct ttttggtggt tgtcgctgtt gccggtgcag tcaccacgac cttacaggtt
    12421 gctttctttc cgcttccatc cgttgccttt actgtaatcg tcacagtccc tgctttcttt
    12481 cctgtcacct ttccctttgc atttaccgtt gcaatctttt tattagaaga agaccatttc
    12541 actgacttct tcgtggcatt tgacggagaa accgtcgctt ttaacgtttt gctctttcct
    12601 tttgtaagat aaatcgtact ataatttaac cccactttta ttacctttac tttagaagct
    12661 gccggttttg tttctgtctt ttttgctgtc gttgaagaag aattccctcc actattactc
    12721 cccgtatcaa tcgtcggact gactaccggc ttcgttcctg ccgaaatagc cacatcactc
    12781 atatcataaa gaaatgtctc tccatccaaa aatctacggt aagcaactgt tgcatacaat
    12841 ccctgttccg ttgccattcc atcgataatg ccaccggcac cgccaccatt attcccggca
    12901 tcagcagcta catgcataaa tcccccttct gattcccctt ctggcatata atactggaat
    12961 aatcctgtca tcggccattt cccattctta ataaaacgga catcttcccc acaatctatt
    13021 cccacgccgc aaagagctgt gataatctgt gccacacttt ccgaagtttc tgtattcatc
    13081 gtgccaaaac caccactgga aagctgattc ttttctatcc acgcaagacc cttgttaatt
    13141 gccgctgtaa catcctcata tccatcttta ttataataag aagccagtgc ctgcatcgcc
    13201 attcccgtca tatcagaatc tccggttggc cccatcatcg tccagccacc atcctgacac
    13261 tgcatcccta caaccttctt aacaagtaac tcctctgagt tttgctgcac tgcagaaggg
    13321 tcttttggaa tctcatatgc cggattactc tttaatgcga tcaaagccca aatcgtgccg
    13381 ttattcccct gtctgcttac attctcataa tctgacagat acgctaacag attatgtccc
    13441 atcacatttc ttgcatcgac accaatcgat gttaatgcaa gaataagctt tgaataatcc
    13501 gaatactttg ctcttgtaat ctgccagtcc ttactctcac agtatgcgat cacattactg
    13561 taaaaaagat ttatataaga ttccggcaca tacagcccac tcctttttaa accaataaca
    13621 ttccatatgc tactgtaatc cggcttcgta tctttactta agatatagct tcttacctta
    13681 gataaaaccg tatcaatatc cgggcttaag acttccgcct ctgcttccgt ctgcactgcc
    13741 actcctgatt catcagactg tccctgtgcc gcatcttcct ctgcacccca agcataaaaa
    13801 ccataacttc ttccaagctg caaattctta cggacaatct ttctctcttt ttttgttaat
    13861 gtctgctctt gtgtactttc ctgtacatct gcctctgtac ttgttgatgt atctgcatct
    13921 tccctggtct gctgcttctc ctcttccgaa gactccgtct cctccctttt tgatgtctcg
    13981 ctttctgaag tctcactttc tgacatagaa aaatcgcctg tactctctgc agtagaa
//
