LOCUS       c00075_gnlPro..        12126 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JBGAHFHO_75.
ACCESSION   c00075_gnlPro..
VERSION     c00075_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 23:58:45
            Original ID  :: gnl|Prokka|JBGAHFHO_75
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12126
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12126
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5100:11218]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5101..11218
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..12126
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12126
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="acetate2butyrate"
                     /region_number="1"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             complement(3..113)
                     /locus_tag="ctg75_1"
                     /transl_table=11
                     /translation="MRFLIFIYGKSRMKRTQLVSDKRAECHILLPKDDFSL"
     CDS             175..1203
                     /locus_tag="ctg75_2"
                     /transl_table=11
                     /translation="MIAKDDIVIRKAILHILDTNRGECILSNTLLDPGPDLHDFIRNHI
                     YKIVSSDDTKNCEFDPEYSPIYSILETWDESDETSFIETSQAIANKLYIAMGEGLDIPA
                     ADLLFVTFQAEGIIYLALLKMNYKESYTHEVTETPDNPVINTDIIKTHSLLPSATSRIP
                     EAVVINLSDYHIKLLEKKYEINGEKAYYLSENFLVCRTSIPPKKKLNILTRVINNISNK
                     YDGADLKTKMDTKSALQKEYVDNKSFDIEEIGNKLFGKSPEKKSEFDEKMEQYDLQYDN
                     FTVTNESTVKKLEKQVMVTDSGIEISIPMETYNKLANFEVQTDVTGKSTIIIRNIDNLV
                     LK"
     CDS             complement(1501..2841)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AcetylCoA_hyd_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AcetylCoA_hydro"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg75_3"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 5.2e-64,
                     bitscore: 204.6, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 1e-30, bitscore:
                     97.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFIKEYAQKLVTAEEAVKVVKSHDWVDYGWTTGTPVALDAALAA
                     RADELEDVKIRGGILLREPEIFKVNNVADHFTWNSWHMGGLERKAISKGFAYYSPLKYS
                     ELPRYYRENIKHLNVAMFQVAPMDKHGFFNFGPNASHMMAVCEAADVIIVEVNENMPRC
                     LGGFEEGIHVSRVDYIVEGENPAIGELGAGAPPTEVDKAVAQLIVEEIPDGACLQLGIG
                     GMPNTVGSMIAESDLKDLGVHTEMYVDAFVDIAKAGKITGLKKNIDRGRQVYAFGAGTK
                     KMYDYLDDNPECMSAPVDYTNSAKTIAQIDNFISINNAVDIDLYGQVNAESAGIKQISG
                     AGGQLDFVQGAYLSKGGKSFICCSSTFTSKDGVKHTRIRPTLAEGSTVTDTRPNTHYVV
                     TEFGKVCLKGMSTWERAEALINIAHPDFRDELIKEAEKMHIWRRSNK"
     CDS             complement(2950..3666)
                     /locus_tag="ctg75_4"
                     /transl_table=11
                     /translation="MLSVMIFCHDKREGDLIGKICNQCVALIDKEFLRNFIISDEEYHQ
                     VNIEGIQPPDLLVVEITGIEDLCRAKRIRGIFPRGRLLVVSTNQISAEYYLIPEVSPDM
                     LLLKPYVYAKACKIIHRSLTWCCKDKCRKKKQEDILKIRTGGEIYYFHYEEIQYLEARD
                     KKIILHVNKYEISFYSSLQKLEKILPDYFIRCHRSYIVNFMFIQKADLINGEFYLNKKT
                     VIPISQKYKAKLAKML"
     CDS             complement(3691..4008)
                     /locus_tag="ctg75_5"
                     /transl_table=11
                     /translation="MADLINVTPEKLKATASSFQQAGKDVKKTTSDMLQLVRGISSSIW
                     SGEASSIYLGKFNGLDADIAKMCKMIEEESQHLTTIAQEYQLAEEQNKQVAATLKNNVI
                     A"
     CDS             complement(4020..4310)
                     /locus_tag="ctg75_6"
                     /transl_table=11
                     /translation="MAQIIASTKEISNKRESLIVLSNSLKNKISLLETLGNSLNSMWEG
                     AAKEKYVRQLKTDISKMRNLLKTILEFILILEKIIAIYNKAEKKNEATAVS"
     CDS             complement(5101..6168)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 166.4;
                     E-value: 2e-51)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_7"
                     /sec_met_domain="ETF (E-value: 4.2e-52, bitscore: 166.4,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 7.9e-39, bitscore:
                     121.5, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSNCKGNVVNRMNLEQYKGVFIYAQQVDNKIDAIALELLGKAND
                     LAADLGTDVTAVLIGSGVKGLVDELAEYGADKVIVVDDPELKEYRTEPYTHALASVINE
                     YKPDILLVGATAIGRDLGPRVSARVATGLTADCTVLEIGEFKARGDKEPRQGQLLMTRP
                     AFGGNTIATIACPNHRPQMATVRPGVMQKKEPVAGAKAEVIEYNPGFTPNDKYVEILDI
                     VKSVTETVDIQAAKILVSGGRGVGSAENFALLDDLAEALGGTVSCSRAVVDNGWKPKDL
                     QVGQTGKTVRPNVYFAIGISGAIQHVAGMEESDIIIAINKDPDAPIFDVADYGIVGDAL
                     KIVPKLTEAIKAQVK"
     CDS             complement(6158..6943)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 163.8;
                     E-value: 1.3e-50)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_8"
                     /sec_met_domain="ETF (E-value: 2.8e-51, bitscore: 163.8,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKIVVCVKQVPDTKGGVKFKPDGTLDRAAMLTIMNPDDKAGLEAA
                     LRIKDETGAEVTVVTMGLPKAEEVLREAMAMGADKGILVTDRVLGGADTWATSTTIAGA
                     LRNIDYDLIITGRQAIDGDTAQVGPQIAEHLDLPLISYAQDIKVEGDSVIVQRQYDDRY
                     HVLKAKMPCVVTALSELNEPRYMTPGGIFDAYDAEITTWGRKDLKDVDDSNLGLAGSPT
                     QIAKASDKVRKGKGVMMTAETAEEGVEYIMDKLLTKHVI"
     CDS             complement(6958..8112)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_9"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.7e-52, bitscore:
                     167.5, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6.3e-31, bitscore:
                     96.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.7e-41, bitscore:
                     131.3, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTLSKKHEMARQLFKEFAENEVKPLAQEVDETEHFPEETVAKM
                     QKLGFMGIPVPKEYGGQGCDPLTYIMCVEELSKVCGTTGVIVSAHTSLCADPILTYGTE
                     EQKQKYLVPLAKGEKLGAFGLTEPGAGTDAQGVQTKAVLDGDEWVLNGSKCFITNGSYA
                     DYYIIIAITSVDTDARGRKKKKFSAFIVEKGTPGFTFGTKEKKMGIRGSATYELIFQDC
                     RIPKENLLGPMGKGFAIAMHTLDGGRIGIAAQALGIAEGALDATIAYVKERKQFGRAIA
                     AQQNTQFQLANMATQVEAAKLLVYKAAMAKATQRVYSVEAAKAKLFAAETAMDVTTKCV
                     QLLGGYGYIREYDVERMMRDAKITEIYEGTSEVQRMVISGNLLK"
     CDS             complement(8213..9052)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_10"
                     /sec_met_domain="HCDH (E-value: 8.2e-39, bitscore: 122.1,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 7.1e-62, bitscore: 198.3,
                     seeds: 60, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVGVIGAGTMGSGIAQAFAQTEGYEVYLCDINDEFAANGKKKIA
                     KGFEKRVARGKMDQAKADAILAKITTGTKDICTDADLVVEAALEVMEVKQQTFKELQDI
                     VPATCMFATNTSSLSITQIGAGLDRPVIGMHFFNPAPVMKLIEVIAGLNTPDEMVEKIK
                     AISVEIGKTPVQVEEAAGFVVNRILIPMINEAVGIYADGVASVEGIDTAMKLGANHPMG
                     PLALGDLVGLDICLAIMEVLYNETGDPKYRPHPLLRKMVRGGKLGQKTGIGFYDYSK"
     CDS             complement(9121..9906)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: EC1_2-faecali"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_11"
                     /sec_met_domain="EC1_2-faecali (E-value: 1.3e-91, bitscore:
                     296.2, seeds: 67, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFIDYEVDGQVGIITINRPKALNALNSEVLKDLDATIDAVDLDA
                     IRCLIITGAGEKSFVAGADIGEMSTLTKAEGEAFGKAGNDVFRKIETLPIPVIAAINGF
                     ALGGGCEISMSCDIRLCSENAVFGQPEVGLGITPGFGGTQRLARIVGPGKAKQLIYTAR
                     NIKAAEAYRIGLVNEVYPLEELMPQAKKMAKGIAKNAPIAVRACKKAINEGLEVGMDEA
                     IVIEEKLFGSCFETEDQKYGMAFFLDKNKEKVKEPFKNC"
     CDS             complement(10037..11218)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_12"
                     /sec_met_domain="Thiolase_N (E-value: 7.6e-104, bitscore:
                     336.4, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Thiolase_C (E-value: 5.1e-51, bitscore:
                     161.3, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKVVLAGACRTAIGTMGGGLSTVPAADLGSIVIKEALKRTNVP
                     VDQVDEVLMGCVIQAGLGQNVARQASINAGLPIEVPAVTINVVCGSGLNCVNLAATKIL
                     AGEADIVIAGGMENMSLAPFCLDKARFGYRMNNGVLKDCMVNDALTDAFNQYHMGITAE
                     NVAEQWHLTREELDEFSANSQQKATAAIEAGKFKDEIVPVEVKLKKKTVVVDTDEGPRP
                     GTTAESISKLRPAFKKDGIVTAANSSGINDGAACVVVMSEEKAKELGVTPMATWVAGAL
                     GGVDPSIMGVGPVASTKKVLAKTGMSIDDFDLIEANEAFAAQSLAVGRELGINPEKLNV
                     NGGAIALGHPVGASGCRILVTLLHEMQKRDAKKGLATLCIGGGMGCSTIVERD"
     CDS             complement(11197..11361)
                     /locus_tag="ctg75_13"
                     /transl_table=11
                     /translation="MKILIKNFFIILLQSEEDCDKINTYRTRNALAKQLSNNIDNLNGG
                     MKLWQRKLY"
ORIGIN
        1 tccaaagaga aatcatcttt aggtaataat atatgacact ctgccctctt atcgctgaca
       61 agctgtgtgc gtttcatcct gctttttccg tatataaaaa ttaaaaatct catagcttct
      121 ttactcctaa agtggtatac tatttaatca aataaaaaat aaaggagctg cctcatgata
      181 gcaaaagatg atattgttat aagaaaagct attttgcata ttttagacac caatcgcgga
      241 gaatgtattc tttctaatac tctcttagat ccagggccag atttacatga ttttattcga
      301 aaccatattt ataaaattgt ctccagcgat gataccaaaa actgtgaatt tgacccagaa
      361 tattctccaa tctattccat cttagaaaca tgggatgaat cagatgaaac ttctttcatt
      421 gaaaccagtc aggccattgc aaataaactc tatattgcca tgggagaggg attagatata
      481 cccgctgccg atttattatt cgtgaccttt caggcagaag gaattatcta tcttgccctt
      541 ttaaaaatga attacaagga aagctatacg catgaagtca ccgagactcc tgataatcct
      601 gttattaata cagacatcat caaaacacat tctctgcttc cttctgcaac ttcaagaata
      661 cctgaggccg tagttattaa tttatccgat tatcacataa agcttttgga aaaaaagtat
      721 gagataaatg gtgagaaagc ttattattta tcggaaaact ttcttgtctg ccgtactagt
      781 attcctccaa aaaagaagtt aaatattctt actcgtgtta ttaataatat ttctaataaa
      841 tacgatggtg ccgatttaaa aacaaagatg gatacaaaaa gtgctcttca aaaagaatac
      901 gttgataaca aatctttcga tatagaagaa ataggtaata aacttttcgg aaaaagtcca
      961 gaaaaaaaat cagaatttga tgaaaaaatg gaacagtacg acttacaata tgataacttt
     1021 actgtcacca atgaaagtac tgtaaagaaa ttagaaaagc aggtcatggt aactgatagc
     1081 ggaattgaaa tatctattcc aatggaaact tataacaaac tggctaactt tgaagttcaa
     1141 acagatgtaa ctggtaaatc aacgattatc ataagaaata ttgataatct tgttttaaag
     1201 taatattaca ttcagaataa actttataaa catattagat tctaaataaa tattacattg
     1261 atacttccac aattattaca ctactgtttt taatattatt tacttgtaaa tattctagag
     1321 cgtgtttgaa aaacattcta gctgtaaata tttattaaat ttaaaaacct cccacacaaa
     1381 atcatctcaa acttgcagtt tgtttatctt ttgtgtgaga ggtttcttga tatcttgcct
     1441 taaattttta ctttttagct aatttcccga catatgatat cttattcaaa gctgtgatta
     1501 ttatttgtta cttcttctcc aaatatgcat cttttctgct tctttaatta attcatctct
     1561 gaaatctgga tgagcaatat taattaatgc ttctgctctt tcccatgtag acataccttt
     1621 aaggcatacc ttaccaaatt ctgttaccac ataatgtgta ttaggacgag tatctgttac
     1681 tgtagatcct tctgctaaag taggtctgat tcttgtatgc tttacaccat ctttggatgt
     1741 aaatgtagaa gaacaacaga taaaactctt accaccctta gataagtatg caccctgaac
     1801 gaaatcaagc tgtccacctg caccactaat ctgttttata cctgcactct ctgcattaac
     1861 ctgaccatat aagtcaatat caactgcatt attgatagaa ataaagttat caatctgtgc
     1921 tattgtctta gcgctattcg tataatcaac tggtgcactc atacattctg ggttatcatc
     1981 cagataatca tacatcttct tagtacctgc accgaatgca tatacctgac gtcctctgtc
     2041 gatattcttc tttaagcctg taatctttcc tgcctttgca atgtcaacaa acgcatcaac
     2101 gtacatctct gtatgtacac ctaagtcctt taaatcagat tcagcaatca tggaacctac
     2161 tgtattaggc attccaccga taccaagctg taaacatgct ccatctggaa tctcttctac
     2221 gataagctgt gctacggctt tgtctacttc tgttggtggt gcgccagctc ctaactcacc
     2281 aatagctgga ttctcgcctt ctacgatgta atctacgcga gaaacatgaa tgccttcttc
     2341 aaatccaccc agacagcgag gcatattctc attaacctct acgataatta catctgcagc
     2401 ttcacaaact gccatcatat gggatgcatt tggtccaaag ttaaagaatc catgtttatc
     2461 cattggagca acctggaaca tcgcaacatt caaatgcttg atattctctc tgtaataacg
     2521 tggaagttct gaatatttta atggagaata gtatgcaaat cctttactga ttgcctttct
     2581 ctccaaacca cccatatgcc aggaattcca tgtaaaatga tctgctacat tatttacctt
     2641 gaaaatctct ggttctctta ataagatacc accacgaatc ttaacatctt ctaattcatc
     2701 tgctctggct gctaatgctg catccaatgc aactggagta ccggttgtcc aaccataatc
     2761 tacccaatca tgagatttta ctaccttaac cgcttcttct gctgtaacaa gtttctgtgc
     2821 atattcttta atgaaactca tgcttctcct cctaacaact tctgctcttg ttaaaaaaat
     2881 atcatgagta tattctacca ccgttgtata actcggtcaa cctaaatcga accttgaatc
     2941 cttatatttt tacaacattt ttgctaattt ggccttatat ttctgagaaa ttggaataac
     3001 tgtcttttta ttcaaataaa attcaccatt tatcaaatct gctttttgaa taaacataaa
     3061 attcacaata taactacgat ggcaacgaat aaaataatct ggcagaatct tctccaactt
     3121 ttgcaaggaa ctataaaaag aaatctcata cttatttaca tgcaagataa tctttttatc
     3181 tcttgcttct aaatactgaa tctcttcata atgaaaataa taaatctctc ctcctgtccg
     3241 aatctttaat atatcttctt gctttttctt tctacactta tccttacaac accatgtaag
     3301 acttcggtgt ataatcttac aagctttcgc atatacatat ggtttcagta aaagcatatc
     3361 cggtgaaact tccggaatta aatagtactc tgctgaaatc tgattagtac ttacaactag
     3421 caatcgtcct cttgggaaaa tcccccttat tcgtttcgct ctgcataaat cctctatacc
     3481 tgtgatttct actacaagta aatctggcgg ctgtattccc tctatattca cctgatgata
     3541 ttcttcatcg cttatgataa aattacgtaa aaattcttta tctataagcg ctacacactg
     3601 attacatatc tttccaatca aatctccttc tcttttgtcg tgacaaaaaa tcataactga
     3661 cagcataatc tattcatctg tctatacaat ctaagcaatt acattattct ttaatgttgc
     3721 cgcaacctgt ttattctgtt cttctgctaa ctggtattcc tgtgcaattg ttgtcaaatg
     3781 ctgtgattct tcctctatca tcttgcacat cttggcgata tcggcatcca atccattaaa
     3841 cttaccaaga tatatactac tcgcctctcc actccagatg gaactactaa ttcccctcac
     3901 taactgaagc atatcagagg tagttttctt aacgtccttt cctgcctgtt ggaaagaact
     3961 tgctgtcgcc tttaacttct ctggagttac attaattaaa tctgccataa atccccctcc
     4021 tagcttaccg ctgtcgcctc attcttcttc tccgctttat tatagattgc aataatcttc
     4081 tctagtatca atataaattc caaaattgtc ttaagtaagt tccgcatctt tgaaatgtct
     4141 gtcttaagtt gccttacata cttctctttt gcagcgcctt cccacataga attaagactg
     4201 ttccccaaag tttctaaaag cgaaatctta ttctttaagg aattactcaa tactatcagt
     4261 gactctctct tattagatat ttcttttgtt gaagcaataa tttgtgccat aaatgcctcc
     4321 tctcatatct cggttaactg ctgcaagagt attataacat atttggaatt aatttccact
     4381 atttttgaca aattatgttt attttgtgat aagtacttct ttattatgtt tattttttat
     4441 tatatataaa ataaaaatga cgtattttac tagagcgtgt ttgaaaaatg ctttctgcaa
     4501 gatgtgcgtt acaatttgtg gaagatttta cctgaatgag ggcggcgtag cgggctacgt
     4561 caactgaatg aaggcaaaat atagcgcaaa ttggggcgtg cagattgtag gaatgatttt
     4621 tcaaacacgc tctagtatag catctatcta atctctaaaa tattattgga tatagttttt
     4681 ctaatttact tcgtgcatct tttattgtga actatcaaat aattattcat aaacactgaa
     4741 tggatgctat actagagcga gtttgaaaaa tgcttttgca agatgtgcgt tacaatttgt
     4801 ggggaatttt tcctgaatga agacggcgta gcgggctatg ccaactgaat gaaagtaaaa
     4861 aagaccacag ttataaactg tagtcctact atctcacttt aacagggaat cttcaaaaag
     4921 attccctgca taaatacatt ttatagagtt cagcacaaat ctcctatatg cttcttttaa
     4981 taatgaatcg tcaatacaca aaacatctga gaatgcatat actagacttc cacaaaaaat
     5041 ctaagtttca atcctcaatc agtaactcac ataatctaat gagtctgata tgatttgaaa
     5101 ttatttaacc tgagctttga ttgcctctgt taacttagga acaatcttta atgcatcgcc
     5161 aacaataccg taatcagcta catcaaagat aggtgcatct gggtctttat tgatagcaat
     5221 gatgatatca gattcttcca taccagctac gtgctggatt gctccggaaa taccgattgc
     5281 aaaataaaca ttaggacgaa ctgtcttacc agtctggcca acctgcaaat cttttggttt
     5341 ccaaccatta tcaacaactg cacgagaaca ggaaactgtt ccgccaagtg cctctgctaa
     5401 atcgtctaat aatgcaaagt tctcagcaga gccaactcca cgtccgccag atacaagaat
     5461 cttagcagcc tggatatcaa ctgtttctgt aacagatttt acaatgtcaa gaatctcaac
     5521 atatttgtca tttggagtaa atcctggatt gtactcaata acttctgcct ttgcacctgc
     5581 aacaggctct ttcttctgca taacaccagg acgaactgtt gccatctgtg gacgatggtt
     5641 aggacaagcg attgtagcga ttgtgttacc accgaatgca ggacgagtca ttaataactg
     5701 accctgacga ggttctttat ctccacgagc tttgaattca ccaatttcaa gaacagtaca
     5761 gtctgctgta agacctgttg caactcttgc agaaacacga ggtcctaagt cacgaccgat
     5821 tgctgttgct ccaaccagaa gaatgtccgg tttgtattcg ttgataacag atgccagtgc
     5881 atgtgtatat ggctctgttc tgtattcttt taattcaggg tcatcaacta cgataacttt
     5941 atctgcgccg tattcagcaa gttcatcaac taagcctttt acgccagaac cgattaaaac
     6001 tgctgttacg tctgttccta aatctgcagc aaggtcattt gcttttccaa gtaattctaa
     6061 agcaatggca tcaatcttat tgtcaacctg ctgagcatag ataaatacac ctttatattg
     6121 ttctaaattc attctattca ccacatttcc tttacaatta gataacatgc tttgttaaca
     6181 gtttgtccat gatgtactca acgccttctt ctgctgtttc agctgtcatc atgacacctt
     6241 tacctttacg taccttatca gaagcttttg cgatctgagt tggagaacct gcaagaccta
     6301 agttgctgtc atcaacatct ttaaggtctt ttcttcccca tgtagtaatt tctgcatcat
     6361 atgcatcaaa gattccgcct ggagtcatat aacgtggctc atttaattcg gaaagtgctg
     6421 tgacaacaca tggcatttta gcttttaaaa catgatatct gtcgtcatac tgtctctgaa
     6481 cgattacact gtcaccttca actttgatat cctgagcata ggaaattaaa ggaagatcta
     6541 agtgttcagc aatctgaggt cctacctgag cagtatcacc atcgatagcc tgacgacctg
     6601 tgatgattaa atcataatca atatttctaa gtgctccagc gattgttgta gatgttgccc
     6661 atgtatcagc tccacctaaa acacggtctg ttacaaggat acccttgtca gcacccattg
     6721 ccatagcttc acgcagaact tcttctgctt ttggaagacc catagtaact actgttactt
     6781 ctgcgcctgt ttcatctttt attctaaggg cagcttcaag acctgcctta tcatctggat
     6841 tcatgatagt aagcatagct gctctatcaa gagttccgtc tggtttaaac ttaactccac
     6901 cttttgtatc aggtacctgt ttaacacata ctacgatttt cacagtattt tccctcctta
     6961 tttcaataag ttaccagaaa taaccatacg ctgaacttct gatgttcctt cgtagatttc
     7021 tgtgatctta gcgtcacgca tcatacgttc tacgtcgtac tctctgatgt aaccataacc
     7081 accaagtaac tgaacacact tagttgttac atccatagct gtttctgctg caaataattt
     7141 agcttttgca gcttctacgg agtatactct ctgtgttgct tttgccattg ctgctttata
     7201 aacaagtaac ttagcagctt ctacctgtgt agccatatta gcaagctgga actgtgtatt
     7261 ctgctgtgca gcaattgctc tgccaaactg ttttctttct ttaacataag caattgtagc
     7321 atctaaagca ccttctgcga taccaagagc ctgagctgca ataccgatac gtccaccatc
     7381 taatgtgtgc atagcgattg cgaaaccttt gcccataggt ccaagaagat tttctttagg
     7441 aatacgacaa tcctggaaaa tcaattcata tgtagctgaa ccacggatac ccattttctt
     7501 ttcttttgta ccaaatgtaa atcctggagt tcctttttct acgataaatg cggaaaattt
     7561 ctttttcttt cttcctcttg catctgtatc aacacttgtg atagcgatga taatatagta
     7621 atcagcataa gaaccgttag tgatgaaaca tttagatccg tttaataccc attcgtcacc
     7681 atctaaaaca gcctttgtct gaacaccctg agcgtcagta ccagcacctg gctctgtaag
     7741 accgaaagca cctaactttt caccctttgc aagtggaaca agatatttct gtttctgttc
     7801 ttcagtaccg taagtaagaa ttggatctgc acacaatgat gtatgtgcgg atacaataac
     7861 acctgttgta ccacaaactt tagataactc ttcaacacac ataatgtatg ttaaaggatc
     7921 acagccctgt ccgccatatt cttttggcac aggaattccc atgaaaccta atttttgcat
     7981 ttttgcaacg gtttcttctg gaaaatgttc tgtctcgtca acctcctgag caagaggttt
     8041 aacttcgttt tcagcgaact ctttaaagag ctgtctagcc atttcatgct ttttgcttaa
     8101 tgtgaaatcc attttcattc ctccataata aattggttat tggggtggag aaccacctta
     8161 aaagccgtgg agacgcagag catagtcccc acggccgtat tcactttttt aattatttgc
     8221 tgtaatcgta gaatccaata ccagtcttct gacctaattt tccaccacga accatctttc
     8281 ttaataatgg atgtggacga tacttaggat ctcctgtttc attatataat acttccatga
     8341 ttgcaaggca gatatcaaga ccaactaaat ctcctaaagc gagaggtccc attggatggt
     8401 tagcacctaa cttcatagct gtgtcgatac cctcaacaga agcaacacca tcagcataaa
     8461 tgccaactgc ttcgttaatc attgggatta agattctgtt aactacgaat cctgcagctt
     8521 cttctacctg tacaggtgtt ttgccgattt ctacagaaat agctttaatc ttttcaacca
     8581 tttcatctgg tgtattaaga ccagcgataa cttcaattaa tttcataact ggagctgggt
     8641 tgaagaaatg cattccgata actggtctgt caagtcctgc accaatctgt gtaatagata
     8701 aagaagatgt atttgttgca aacatacatg ttgcaggaac gatatcctgt aattctttaa
     8761 atgtctgctg tttaacttcc ataacttcaa gagctgcttc tactactaaa tcagcatctg
     8821 tacagatatc ttttgtacct gtagtgattt tagcaaggat tgcatcagct ttagcctgat
     8881 ccatttttcc tcttgctact ctcttttcaa atcctttagc gattttcttt ttaccgtttg
     8941 cagcaaattc atcgttgata tcacataaat atacttcgta tccttctgtc tgtgcgaatg
     9001 cctgagcaat acctgatccc attgtacctg cgccaataac tccaactttc attgtttgaa
     9061 acctcctata aaatgtaatg tattccgata attaataata caatatgtat aattgattaa
     9121 ttagcagttt ttaaatggct cttttacttt ttctttgttt ttgtcaagga agaatgccat
     9181 tccgtatttc tggtcttctg tctcgaagca gctgccaaat aacttctctt cgattacgat
     9241 agcttcatcc attcctactt ctaaaccttc gttgatagct ttcttacatg cacgaactgc
     9301 gataggtgcg ttctttgcaa taccctttgc catcttctta gcctgaggca ttaactcttc
     9361 gagtggataa acttcgttaa ccagaccgat tctgtaagct tctgctgctt taatattgcg
     9421 agcagtatag attaactgtt ttgcttttcc aggtcctacg atacgagcaa gtctctgtgt
     9481 tccaccaaaa cctggtgtga ttccaagacc aacttctggc tgtccaaata ctgcattctc
     9541 agagcaaagt ctgatgtcac agctcataga aatctcacag ccaccgccta aagcgaatcc
     9601 gttgattgct gcgataacag ggattggaag tgtttcaatc tttctgaata catcattacc
     9661 agctttaccg aaagcttcgc cttctgcttt tgtaagtgta ctcatctctc cgatatcagc
     9721 acctgccacg aaagatttct ctccagcacc agtaatgata agacatctga ttgcgtctaa
     9781 atctactgca tcaatagttg catctaaatc ttttaatact tcactattta aagcatttaa
     9841 agcctttgga cgattgatgg tgataatacc aacctggcca tctacttcat aatcgataaa
     9901 tcccattgta tgtatctcct ttcagattac attagctaac tattcaatct agataattaa
     9961 atagttacaa actatgtaat tgatataacc ggattcgaaa accgaacccg gatatatgta
    10021 atcattctat acgtgattag tctctttcaa cgattgttga gcagcccata ccaccaccga
    10081 tacacagtgt tgcaagacct ttctttgcat cacgtttctg catctcatgt aataatgtaa
    10141 cgaggatacg gcatcctgat gctcctactg gatgtccaag agcaatagct ccaccattaa
    10201 catttaactt ctctgggttg attcctaatt ctcttcctac tgctaatgac tgagctgcga
    10261 aagcttcgtt agcttcgatt aagtcaaagt catcaatgct catgcctgtt tttgcaagaa
    10321 ctttcttagt agaagcaact ggtccaacac ccatgataga aggatcaact ccgcctaatg
    10381 ctcctgctac ccatgtagcc attggagtta cacctaattc tttagctttt tcttcgctca
    10441 taacaacaac acaagcagca ccatcgttaa tacctgaaga gttggcagct gttacgatac
    10501 catctttctt gaaagcagga cgtaatttag aaatactttc tgctgttgtt ccaggacgtg
    10561 gtccctcatc tgtatctaca acaactgttt tctttttaag tttaacttct acaggaacaa
    10621 tctcatcttt gaacttacca gcttcgatag ctgctgtagc tttctgctgt gaattagcgg
    10681 agaactcatc taactcttct cttgttaaat gccactgttc tgcaacgttt tcagctgtaa
    10741 tacccatatg gtactgattg aaagcatctg ttaatgcatc gttaaccata cagtctttta
    10801 atacgccatt gttcattctg tatccaaaac gagctttgtc taagcagaat ggagctaatg
    10861 acatgttttc cataccacca gcgataacga tatcagcctc acctgctaaa atctttgtag
    10921 cagcaaggtt aacacagtta agaccggaac cacaaactac gttaattgtt acagcaggta
    10981 cttcgattgg taagcctgca ttaatagaag cctgacgagc aacgttctgt ccaagaccag
    11041 cctggataac acatcccatt aatacttcgt ctacctgatc aacaggtacg ttagttctct
    11101 ttaacgcttc tttaattacg atgcttccta aatctgcagc tggtactgtg cttaatccac
    11161 cacccattgt tccgattgcg gtacgacaag cacctgctaa tacaactttc tttgccatag
    11221 tttcattcct ccatttaagt tatcaatatt atttgatagt tgctttgcta gagcatttct
    11281 agtacgatat gtgttaatct tatcacaatc ttcttcgctt tgcaacaaga ttataaaaaa
    11341 atttttaatt aatattttca tttatgaaag attcacagtt tcgtcacttt tgaatacaaa
    11401 atccatcgtt gttttaatta attttacctt tatttcttct tatatctatg gacattctct
    11461 attgattaat tttctgattt tgtgaaaaaa ggaaacaaaa tacaaaaaac cgcctaaata
    11521 tgtgaagaaa tagacattct gagttggcta atggacgaaa aaccagagat actttacctg
    11581 ccagatgcgg ctttggagtg agttttatgg cattttgcac agtgaaataa agcatatggt
    11641 agataaagta tctctggctt ttctatctgt tggaaggatt tagtttagaa tgtctatatg
    11701 gagagatttg aaaatttccc ggatagctgt agatgaaatt atgtatattt tgtattgcaa
    11761 tttgttttta tcattgtaat tatattaaca aaatcaatac caaaaaatct atattttaaa
    11821 ttcacacact ctccccaaca tcgaatcgtt gcacatctaa gaatttttac tttgtttcct
    11881 tcaaagtcag caatagtaaa gctcgctata agtctatctg tggcctcgga gcaagtgttg
    11941 gatgcgagcg tctaagcgaa cattcaacac gccgcgacta aagtcacaga tagacttata
    12001 gcgggtttta ctattgcgtc agtttaaaca aataaaaaaa caccgatacc aacgtaccga
    12061 tgttcctcaa attgcggggg aaggatttga accaacgacc tccgggttat gagcccgacg
    12121 agctac
//
