LOCUS       c00098_gnlPro..        15588 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HFCOLFJE_98.
ACCESSION   c00098_gnlPro..
VERSION     c00098_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 01:19:29
            Original ID  :: gnl|Prokka|HFCOLFJE_98
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15588
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15588
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1031:5588]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1032..5588
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15588
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15588
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             3..845
                     /locus_tag="ctg98_1"
                     /transl_table=11
                     /translation="VSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTF
                     ETCKSCIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVS
                     SDHHTYTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFE
                     VLDAVMEKLPGFPIVLHGSSSVPEEEVETINKYGGALKAAIGIPEEELRKAAKSAVCKI
                     NIDSDSRLAMTAAVRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAQ"
     CDS             complement(1032..2192)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg98_2"
                     /sec_met_domain="OAD_beta (E-value: 1.2e-153, bitscore:
                     501.4, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLVFIYLAIAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(2194..2625)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg98_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 6.2e-22, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPV
                     AKPVTVRPMPNAPAAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             complement(2650..3570)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg98_4"
                     /sec_met_domain="OAD_gamma (E-value: 1.1e-15, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQSNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGKKLLDQIVVPAGALGPNQSYARVSDGAAEW
                     EVKSGSGDKYVTPSTNNKTLDSNSKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             complement(3602..5155)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg98_5"
                     /sec_met_domain="CT_Btheta (E-value: 6.2e-291, bitscore:
                     955.2, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYLFAQDFTVTAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLALIRTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPN
                     KPYDMYEVISAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(5184..5588)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg98_6"
                     /sec_met_domain="Glyoxalase_4 (E-value: 2e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(5764..6762)
                     /locus_tag="ctg98_7"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNAFHSKELFQIYEATPGYTPLLIVA
                     TEDGRPVARLLAAIRKAKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEVFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRANDYFPVNWLRVRNSLHSMKKTEDRFSPSRI
                     RQIKKGLKNGAKVEEAHTVEEIHDFSRMLHKVYSSRIRRYFPANDFFRHMNDMLIKGQQ
                     AKIFVVKYKEKIIGGSVCIYSGDDAYLWFSGGMKKTYALQYPGVLAVWKALEDARQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRVNWNWLNKLLVKFYV"
     CDS             6913..7455
                     /locus_tag="ctg98_8"
                     /transl_table=11
                     /translation="MLEEILAYNKQFVENKGYESYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EVMLEKMKARGINPDYIDMMRFCGVDFHSWLDGFEDTEKSVRGTVDFIVRHPLIPSDVT
                     VYGFIIDSTTGELTRIV"
     CDS             complement(7545..7769)
                     /locus_tag="ctg98_9"
                     /transl_table=11
                     /translation="MKKRITQDDYIKANRKASREAEIEMYGHPICHKRVHQLKKVYNRR
                     KIKAADKKLPYFFVFKIASLSSRHSDTIQ"
     CDS             7950..8486
                     /locus_tag="ctg98_10"
                     /transl_table=11
                     /translation="MENFSELIRNRRSMRKFTDEELTQDQVVTLMKAALMSPSSKRSNS
                     WQFVVIDDKEVLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILGIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             8489..8824
                     /locus_tag="ctg98_11"
                     /transl_table=11
                     /translation="MGAAKASNSKDTYLATAVTFIVIGALYLIDKLIHFSTLGLPWVMN
                     KDNMLLYASICFLIFKRDKSIGFVLLGLWLVMNISLVISLLGSLSGYLLPLTLLIVGII
                     LFWFAKR"
     CDS             8832..9626
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg98_12"
                     /sec_met_domain="F420_oxidored (E-value: 7e-15, bitscore:
                     45.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYHKGFRIVQVYSRTMESAR
                     TLAEKVEAEYTTDLQEVSKDAKLYIVSLKDAALVDLLPQITEGKQNSLLVHTAGSIPMS
                     IWEGYAERYGVFYPMQTFSKQREVNFQEVPFFVEAKRPEDVELLKAVAATLSEKVYEAS
                     SEQRKSLHLAAVFICNFTNHMYALAADLLEKYNLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMNNHLAMLVDSPALQEIYKLMSKSIHEHHQL"
     CDS             9607..10128
                     /locus_tag="ctg98_13"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFEGLGVKDLYMGSAVKIHDYRDFRDKYGLTDDE
                     ILYMGDDVPDIEVMRECGLPCCPKDAVPEVKSVAKYISYADGGRGCGRDVVEQVLKAHG
                     LWMAEDAFGW"
     CDS             10199..10780
                     /locus_tag="ctg98_14"
                     /transl_table=11
                     /translation="MLDNLKKYQIILASNSPRRKELMSGLGVDYVVRTLPDVDESYPDT
                     LVGAEIPEYIAREKADAYRTMMQPGELLITADTIVWLDGKVLGKPEGREGAIEMLRALS
                     GKSHQVFTGVCLTTTEWQKSFTASSEVLFDVLSEDEIQYYVDRYQPMDKAGAYGVQEWI
                     GYIGVKSISGSFYNIMGLPIQKLYGELKKL"
     CDS             complement(10924..13128)
                     /locus_tag="ctg98_15"
                     /transl_table=11
                     /translation="MNEKTINEQYAYIRTLLEEKRLKEALMQLESLLWQCPDWDLRTRL
                     EQLQTSYKYMLEYMKQGANDPDRWNLYQKMVADTWGIADQSRLLMLDNASSRYYHEVRR
                     TPRSADLSNYGIKTILHILESFNDDLAVSGLLSDEKMDEVLRRHEDTLKFMFIRTWTNS
                     AWTPEDEEDAKAMLASELLPGDDLCLFVSALTLSLMECFDLRKIMWLLNAYEHPNVNVS
                     QRALVGTMIIFHIYRSRLSFYPELIKRVDLMEEIPSFREDVARIYRQMLLCQETEKIDK
                     KMREEIIPEMLKNVSSMKNMRFGFEENDEENNDMNPDWEDAFEKSGLGDKLREMNELQL
                     EGADVYMSTFAALKNYPFFREVHNWFYPFSKQQSNVLKAMKQAGNQGGSLLDLILQSGF
                     FSNSDKYSLFFTIHQLPQSQQDMMLSQLNEQQVAELAEKSNVETMKRFNERPGTVSNQY
                     LHDLYRFFKLSVRKSEFRDIFKEKLDLHHVPALDNILYWEDVLFPIADFYLAKERWDEA
                     IEIYEELESIGGFEGESAEYYQKFGYALQKRKKYAEAIQAYLKADTLKPDNIWNNRHLA
                     ICYRLNRNYQAALTYYKKVEEAAPEDTNVTFYIGSCLAELGQYEEALNYFFKLDFIENN
                     CIKAWRGIGWCSFISQKYEQAMKYYEKIIKQKPLAIDYMNAGHVAWVMGDIQKAAVFYG
                     KAITASGNRERFLEMFHKDEESLLTQGIREEDIPLMLDLL"
     CDS             complement(13139..14323)
                     /locus_tag="ctg98_16"
                     /transl_table=11
                     /translation="MEHKIAETNARIDVADVLRGLAVMGIILLHSIEHFNFYSFPEEVP
                     FEWMKFTDQAIWRGLFFTFSNKAYAVFALLFGFSFYIQDNNQQRRGKDFRLRFLWRLFI
                     LFMIGQFNAAFFTGEILTMYAILGIILPIFCRMSDRTVVIFATLLILQPIDWVKLIYAL
                     CNPDYVAGKSLAGYYFSIAFDVQKNGTFLETVRMNMWEGQLANMTWALEHGRILQTPGL
                     FLFGMLVGRRKYFLYSEQNERLWLKALAVSLLCFFPIYGLNNMLPEFIERSAILVPLQL
                     ILSSFSSLSFMVLLVTGLLLTFYRVKDRSFFMRFTSYGKMSLTNYLGQSIFGSLLFYHW
                     GFELGRYLGITYSFLFGILFVLLQMVFCSWWLRHHKHGPFEGLWKRLTWIGKNK"
     CDS             complement(14440..15483)
                     /locus_tag="ctg98_17"
                     /transl_table=11
                     /translation="MRKTLLQLLTFVLCITGMQNPLLAQEQTPLNQVVNTLKERISLSG
                     YAQLGYTYDDAANPDNTFDIKRIIFMAHGKITKRWTCDFMYDFYNGGMLLEVYTDYQFL
                     PGLTARIGEFKVPYTIENELSPTTVELINCYSQSVCYLAGVSGSDKCYGMTSGRDIGMM
                     LHGKLFRDFLQYKVAVMNGQGLNTKDKNSQKDVVGNLMVNPLRWLSVGGSFIRGTGHAI
                     ADSEYTEIKTGENYAKKRWSAGGIVTTSTFNLRTEYLAGKDRSVKSEGFYATGSVRFAR
                     NFDFIASFDYFNPNKAADFKQNNYIAGVQYWFYPRCRLQAQYTFCDKKGDGQKDSNLIQ
                     AQVQVRF"
ORIGIN
        1 aggtttctaa aggtgctcgt cagtatgcta acgctacttt gttgcgttac atggcacagg
       61 gtgctgtaga atatgctaaa gaattaggct gcgcacatcc ggaaatcgtt cttcaccttg
      121 accacggaga tacattcgaa acttgcaaat cttgtatcga ttctggtttc tcttcagtaa
      181 tgatcgatgg ttctcacctt ccttacgaag aaaacgtagc attgactaag aaagttgttg
      241 aatacgctca ccagtttgac gtaactgtag aaggtgaact tggcgtattg gctggtgtag
      301 aagatgaagt ttcttccgac catcacacat atactgaccc tgaagaagta atcgacttcg
      361 ctactcgcac tggttgcgac tctttggcta tctcaatcgg tacttctcac ggtgcttaca
      421 agtttactcc ggaacaatgc cacatcgacc cgaagactgg ccgtatggtt cctcctccat
      481 tggctttcga agtattggac gctgtaatgg aaaaacttcc gggattccct atcgttcttc
      541 acggatcatc ttcagttccg gaagaagaag tggaaactat caacaaatat ggtggtgcac
      601 tgaaagctgc tatcggcatt ccggaagaag aattgcgtaa agctgctaag tctgctgttt
      661 gcaaaatcaa catcgactct gactctcgtc tggctatgac tgctgctgta cgtaaggtat
      721 tcgctgaaaa accggctgaa ttcgacccac gtaagtatct tggcccggct cgtgacaata
      781 tggaaaaact gtacaagcac aaaatcatca acgtgctcgg ttctgacaat aaattggcac
      841 agtaataatc tccggattat tccataaata aaagaaagag gctgctccgg tttgaacact
      901 ggtagcagcc ttttttatga cgtttaatcg tttctgaacg gagggaagat aacactatgg
      961 ctgtaattaa agaacacccg tgtcacaact gaatgtaaca cgggtgttct tatctattat
     1021 aataatgttt cttacatcaa gaatccaagc aggataccgg cagcaacagc tgaaccgatc
     1081 actccggcaa cgttcggacc catagcgtgc atcagcaaat agttggtcga atcgtattcc
     1141 aaaccaatca cttgtgagat acgtgcagag tcggggacag cagaaacccc tgcattaccg
     1201 atcaatggat tgatcttgtt gcccttcttc aagaagatat tgaatatctt aacgaagatt
     1261 acaccggatg cagttgcaat gatgaatgac aatgcaccga gggcgaaaat cttgatagaa
     1321 tcgagcgtca ggaattcgga agcttgcgta gaagcaccta ctgtcagacc caacaggata
     1381 gtgattgtat caatcaacgg accactggca gtattagcca aacggcgggt tacaccactt
     1441 tctttcaaca ggttaccgaa gaacagcata cccagcaaag gcagaccgga aggaaccagg
     1501 aaacaagtca gcaacaaacc gatgatcggg aaaatcacct tctccgtgtg agaaacggca
     1561 cgcggcggtt tcatgcggat gacacgttcg ttcttggtgg tgagcagacg catgataggc
     1621 ggctgtatca ccggaactaa cgccatatag gagtaggcgg acaccgcaat ggctcccatc
     1681 aggttaggtg ctagcttgga agaaaggaag atggccgtcg ggccgtctgc tccaccaatg
     1741 ataccgatag caccggcttg catcgggtcg aagcccattt ctagcgcgat catataagca
     1801 ccgaagatac cgaattgtgc agctgcaccg atcagcatca attttggatt agagataagt
     1861 gccgagaagt ccgtcatggc gccgatgccc aaaaagatga gcggcggata ccagccggag
     1921 gtcactccct gatacaatat attcaataca gaaccttctt cataaatacc gactttcagc
     1981 ccggcatcca tattaaaagg tatgttaccg attaatatac cgaaaccgat aggaatcagc
     2041 agcattggtt cgaactcttt ggctattgcc aaatagatga ataccaagcc aacgagaatc
     2101 atgactacat gccctaccgt agcattggca aagcctgtgt atgtccagaa gtcggccagg
     2161 ttatttccta aaaagtttat aaaatctccc atattattca ataattacga ggtcattacc
     2221 ttcaagaaca gagtctccct tgttgacgtt gatggcagta atcttaccgt ccttatccgc
     2281 attgatattg ttttccatct tcatggcttc caatatgata atggtctgtc ctttctttac
     2341 agtatcgcct acattcactt tgatgtcgag gatcacaccc ggcaacggag attttactcc
     2401 tgattttccg gtagacggag cggtcggttt cactacttga gtaggagcag caggagcatt
     2461 aggcatcggg cgtactgtca cgggtttcgc aacaggcttc ggctgtttct ccatttctac
     2521 tttatagtgt gtaccgttca cttctacatg agcgatgttg tcttcaatat ctccgatggt
     2581 tactttatat gagttaccgt tgattttata tttatattct ttcatcgttt ttacttttta
     2641 aaaggtgact tactttctgg gaggagtttc acgcaaagtg taaatcttcg aactccatgg
     2701 tgagtagctg cgttttacgc gggtgatggt cagcaccgtt tcttctacgt cgtgcacctc
     2761 atcctgcatt tcgtgtaatg ccatagaaat agcagcgtat acttcgcccg gagcctgtga
     2821 cagttcctta gcttcatgct tgtcaatgcc tttagatttc atagcgttgc gcttgctcaa
     2881 attaacagct acttttccta caatcttaaa agcaataaag agaagaatca atccgcagaa
     2941 tactacgctc atggcagaaa tggacattcc aacgccatca gcatcgtgtt cttcaaactt
     3001 ttccatcttg gaattgctgt caagagtctt gttgttggtg ctcggagtca cgtatttgtc
     3061 accgcttcca ctttttactt cccattcagc tgccccgtcg cttacacgag cgtatgattg
     3121 gttgggaccg agcgcgcctg cgggcactac aatctggtcg agcaactttt tgccggagtc
     3181 gaacagacca acccaattag ctgtttccgg attcagcttg aagctggtat ggaaagtacc
     3241 acggttaggt tcgccatctg cccagaatag tgcatgttgg cgtggtttca ctaaagtaag
     3301 tatatcacct ttcgggataa aataagtaac tgtatcgccc ggttggctac ttactttcag
     3361 caagcaagct gccaggtcgg cgctaccgaa tgatttattg aatatttcaa tccatgcgct
     3421 gtgcaatccg taatcgtcct gaaaattact ctgattgtct atcaggattt cgtttagcac
     3481 cagcttattg ttcgactttt gctctccaca agaagtcaaa ccaatcagca acagcaaaga
     3541 aaggaatatt ccgattttgg ttttgttcat aatcgttctt gttttaatgt gaaaagttgg
     3601 attacaacgg aatattacca tgtttcttcg ccgggttaga cagtttctta gtctgcaact
     3661 gctgcaaagc acggatcacg cggaaacgtg tgttacgcgg ttcgatgaca tcatcgatgt
     3721 aaccatactt agctgcatta taagggttgg caaacagttt tgtatattct gcttcttttt
     3781 cggcaaggaa ctgagccgga ttttcctggt ctttggcttc acgcgcgtac aatacttcta
     3841 ctgcacctgc accacccatt acagcgattt cagctgttgg ccaagcatag ttcatgtcac
     3901 cacgaagttg tttacaactc atcacgatgt gagaaccacc gtaagattta cgcaatgtga
     3961 ttgttacttt aggtacagta gcttcaccgt aagcatacag cagtttggca ccatgaagga
     4021 taacaccatt gtattcctgg cctgttcccg gaaggaatcc cggtacgtct accaacgaca
     4081 cgatagggat attgaaagca tcgcagaaac gaacgaaacg tgcgcctttg cgagatgcgt
     4141 tgctgtcgag tacaccggca aggaatttag gctgattggc tacaatacct acagactgac
     4201 cgttgaaacg ggcaaaaccg ataatgatat tcttggcata gtctttctgg atttccagga
     4261 attcaccgtt gtccacgata gcgctgataa cctcgtacat atcatacggt ttgttggggc
     4321 tgtcggggat aatatcgttc agtgaatctt ccagacggtc gatcggatct gtgcaatcca
     4381 catatggagc ttcttcgagg ttgttttgag gaatatagct cagaagtgtg cggatcaatg
     4441 ccagaccttc ttcttctgtt ttggcagtga aatgagtaac acccgatttg gtagagtgaa
     4501 cgcttgctcc gccgaggttt tcctggctta cgtcttcacc ggttacagtt ttcactactt
     4561 tcggacctgt aaggaacata taagaagtac cttccatcat cagtgtgaag tctgtcagtg
     4621 ccggagaata aacagcaccg ccggcacaag gcccgaagat accggaaatc tgcggaatga
     4681 cacccgaagc gaggatattg cgctggaaga tttctgcgta acctgccaaa gcgttaatac
     4741 cttcctggat acgtgcaccg cccgagtcat tgataccgat acaaggagca cccatcttca
     4801 ttgcctgatc cataatctta cagatcttca gtgacattgt ttccgacagt gaacctgcag
     4861 taacggtaaa gtcctgtgca aaaagatata cgagacgacc ttcgatagta ccgcaaccgg
     4921 ttactacacc atcacccgga tagtgctttt tctccatgcc gaagttcgtg catctgtgct
     4981 caacgaacat gtccatttct tcgaagctac cttcatccaa cagcatggct atacgctcac
     5041 gcgctgtgta tttccctttt tcatgttgct tcgcaattgc tttttcgccg cctccgatgc
     5101 gtgcaacggc acggcgttca ataagctctt taattttttc aagttgatta ctcatgagtt
     5161 cttgttggtt ttagagttta tgattaatgt tcgcagagtt ctgtcaacac gcccaaagtt
     5221 gatttcgggt gaaggaaagc aatattcaaa ccttcggcac ctttgcgggg agctttgtcg
     5281 ataaggcgga tttctttgct ttctgcttct gccaaagcat tggctacgcc atcttctaca
     5341 gcaaaggcta catgatgaac acctgcacct ttgttttcaa tgaatttggc aatagtactc
     5401 tccgggcaag tcggctccaa cagttcaatt ttggtttcgc ctacttttaa aaaagcagtt
     5461 cttactttct gatcttccac tgtttcaatg ttgtaacact tcagacctaa tacattttcg
     5521 tagtaaggaa gggcttcttc gatgcttttt acagcaatgc ccagatgttc aatgtgtgaa
     5581 atcttcataa ctatactttt tttatttggt tttaatcatg tgcttatatg gcataaaaca
     5641 gcacaaagaa agacatttct tacctaataa agaaatattt ctgcatttaa ttattggatt
     5701 attaaacaga aaaaatggta gggaaggagc atgaagagtc gttttgcaat cttgagatta
     5761 catttagaca taaaatttga ctaagagttt gttcagccaa ttccaattga cacggaacca
     5821 gcggcgggta ctgctttgct ttcctccgaa tcggagaacg aaatcacgat aaccgtgttt
     5881 gcggaacgga agtcctacat ccataaattc catgtgacgg aatccccgtt ggcgggcgtc
     5941 ttccaatgcc ttccaaacgg ccagcactcc cggatactga agtgcgtatg tctttttcat
     6001 tcctccggaa aaccaaaggt acgcgtcatc tcccgagtag atacagacgg aaccgccaat
     6061 gattttctct ttgtatttta ctacgaatat ttttgcctgt tgtcctttga ttagcatatc
     6121 gttcatgtga cggaaaaagt cgttggcagg gaaatatctg cgtatgcggg aggaataaac
     6181 cttgtgcagc atccgtgaga aatcgtgtat ttcttccacg gtatgtgctt cctctacttt
     6241 ggctccattc ttgagtcctt tttttatctg acggatgcgt gacgggctga accggtcttc
     6301 cgtctttttc atactgtgca gcgaattgcg tacccgcagc cagttgacag ggaaataatc
     6361 attggcacgg aaaacccggt aaccgaacat cgaattattg aggttccgga attcgatcag
     6421 gacacagcta cgcgatgctt cttgtgtgag atgttcgagc atatcgccaa agacttcttc
     6481 tgccttttct ttgttggtcg aaagcgactc atctagaaat tcaccttcgc tatatactac
     6541 gcaatgtttc actaaagagg agggaagcca ctttttcgct ttgcggatgg cagcaagcag
     6601 gcgtgccaca ggtctgccgt cttctgttgc tactattaat aaaggagtat accccggagt
     6661 cgcttcataa atctgaaata actctttgga atggaaggcg ttttttccgg gcaattcagg
     6721 aatgtccttc ccatgataat atgtggttag tttaagtggc atctaggtac aaatttacac
     6781 tttttattct ttattcaaca acaaaacaga gattttgttg gaactgcctg atatatatag
     6841 ttgtaaaaaa tgcaccttta tatatttttt ctatctttgc gtaatcgaac agaactttta
     6901 aaaagcggaa ctatgttaga agaaatttta gcttacaaca agcaatttgt tgagaacaag
     6961 ggatacgaat cgtatattac caataaatat cccgataaga aaatagctat tctttcctgt
     7021 atggataccc gactgactgc tttgctgcca gcagcattag gaattaagaa tggcgatgtg
     7081 aaaatgataa aaaatgcagg tggcgttatt tcccatcctt tcggtagcgt gatacgtagt
     7141 ttacttgtag ctatttttga gttgggggta gaggaaataa tggtgattgc tcattctgac
     7201 tgtggagctt gccacatgca cagtgaagta atgctcgaaa aaatgaaagc acgcgggatc
     7261 aatccggatt atattgacat gatgcgtttc tgcggagttg actttcattc gtggctggat
     7321 ggtttcgaag atacagaaaa gtcggtgaga ggaacagtag attttatcgt gcgtcatcct
     7381 ttgatccctt cagatgtgac agtctacggg tttattattg attctacaac cggggaatta
     7441 actcggattg tatagataat tagatagatt aggtaaatag ataaacttct tttttaatcc
     7501 cctaaatata gtgacgctat cctatcatga tagtgacgcc attcctattg tatagtgtcg
     7561 ctatgtctgg aggatagtga cgctattttg aagacaaaaa aataaggcag ctttttatcg
     7621 gctgccttta tctttctacg gttatatact ttctttaact ggtgcactcg tttgtgacaa
     7681 atagggtgcc cgtacatctc aatttctgcc tcacggctag ctttacgatt cgctttaatg
     7741 taatcgtctt gtgtaattcg ctttttcata atgaaattat ttatctgtgc aaagatacaa
     7801 tatattcttc atttagtgga gtatttggca ctcttttcat ctcatagatt cccttctgac
     7861 aatagaaatg aaaaagatac ttttatttcc tattacgctc ggtttgcatt atctttgcat
     7921 acattaatca aatgaaaccg gaaaataata tggaaaattt cagtgaatta ataaggaacc
     7981 gtcgtagtat gcggaagttc accgatgaag agttgacaca agatcaggta gttacgttga
     8041 tgaaagcagc tttgatgtct ccttcttcca aacgtagtaa tagttggcag tttgtagtga
     8101 ttgatgataa agaggtattg aaagaattgt ctcattgtaa ggaacaggct tcttcattca
     8161 ttgccgacgc tgctttggca attgtggtaa tggccgatcc gttggccagt gatgtttgga
     8221 ttgaagatgc ttctattgct tctatcatga tacagttgca ggccgaagat cttggcttgg
     8281 gaagctgctg ggtgcaggtc cgcgaacgtt tcactgctac cggaatgcct tccgatgaat
     8341 ttgttcatgg aatcctgggc attcctctgc aacttcaaat tctttccgtt attgctatcg
     8401 gacataaagg gatggaacgt aaacctttca acgaagaaca tcttcaatgg gagaaaattc
     8461 acataaataa attcggagga aaataaatat gggagctgct aaagcgagta acagcaaaga
     8521 tacttatttg gctactgctg ttacctttat cgttatcgga gcactttatc tgattgataa
     8581 actgattcat ttctctaccc tcgggttgcc ttgggtgatg aataaagaca atatgttatt
     8641 gtatgcttcg atctgttttc ttattttcaa acgcgataaa tcaattggtt ttgtgttact
     8701 tggtctttgg ctggtgatga atatcagttt ggtaatatca ttgctgggtt cgttatccgg
     8761 gtatctgctg ccattgactt tgctcattgt cggcatcatt ttattctggt ttgcaaaacg
     8821 gtaaggaaat aatgaagaga agtatagaag atacaccgat tgtgtttatt ggcgcaggta
     8881 atctggctac taatctggcg aaggctctct atcataaagg cttccgtatt gtgcaggtat
     8941 atagccggac catggaatct gcccgtactt tagccgagaa agttgaagct gaatatacta
     9001 cagatttaca ggaagtctcc aaagatgcca aattgtatat tgtatctttg aaagatgccg
     9061 ctttagtaga tttgttgccg cagataacag aagggaaaca gaattctttg ttggtgcata
     9121 ccgcgggaag tatcccgatg agtatttggg aagggtatgc agaacggtat ggagtatttt
     9181 atccgatgca gacattcagc aaacaacgtg aagtcaattt tcaggaagtg cctttctttg
     9241 ttgaagcgaa acgaccggaa gatgtagagc tcttgaaagc tgttgccgcc actctttcgg
     9301 agaaagttta cgaagcttct tccgagcagc gtaaaagcct tcatttggct gctgttttta
     9361 tctgcaattt cacaaatcac atgtatgcat tagctgctga tttgcttgaa aaatacaact
     9421 tgcctttcga tgtcatgctt ccgctgatag atgaaacggc acgtaaagta cacgaactgg
     9481 caccgcgtga tgcacagacc ggacccgctg tccgttacga tgagaatgtg atgaacaatc
     9541 atcttgccat gttggtagat tctccggcat tgcaggaaat atataaacta atgagcaaaa
     9601 gtatccatga gcaccatcaa ctatgattta tcccgtatca aggctttagc ttttgacgta
     9661 gacggagtat tgagttcgac aaccgtacct ttgcatcctt ccggagagcc gatgcgtact
     9721 gtgaatatca aagatgggta cgctatccag ttggctgtga aaaaaggact tcacatagcc
     9781 atcatcaccg gtggccgtac agaagcagtg cgtatccgtt ttgaaggact gggagtgaag
     9841 gatctgtata tgggatccgc cgtcaagata cacgactatc gtgattttcg tgataaatac
     9901 ggactgaccg atgatgaaat tctctatatg ggcgatgatg ttccggatat tgaagtgatg
     9961 cgtgaatgtg gacttccatg ttgtccgaaa gatgccgtgc cggaagtgaa atccgtagca
    10021 aagtatatct cttatgcaga cggcggacgt ggttgcggac gtgatgtagt ggagcaagta
    10081 ctgaaagctc atggtctgtg gatggcagaa gatgctttcg gctggtgaaa tcaactggtg
    10141 acatcaataa aaagtatttt caaccataaa ccataaatta taaatcataa atcgaatcat
    10201 gcttgataat ttaaagaaat atcagattat actagcctcc aattctcccc gtcggaaaga
    10261 attgatgtca ggcttgggag tggactatgt agtcagaaca ttgccggatg tagacgagtc
    10321 atatccggat acattggttg gtgctgaaat acccgaatat attgctcgtg aaaaggcaga
    10381 tgcctaccgt accatgatgc agccgggaga attattgatt acagcagata ccatcgtctg
    10441 gctggatgga aaagtacttg gaaaaccgga gggcagggaa ggagccattg aaatgcttcg
    10501 tgctctttcg ggaaagtctc atcaggtttt cacaggtgtt tgcctgacta ctaccgaatg
    10561 gcaaaaaagc tttaccgctt cctctgaagt attgtttgat gtcttgtcag aagatgaaat
    10621 ccagtattat gtcgaccgct atcagccgat ggataaggca ggagcgtatg gcgttcagga
    10681 atggatcggg tatatcggtg tgaaatcaat ttcaggtagc ttctataata ttatgggact
    10741 tcccatacag aagttgtatg gagagttgaa aaagttatag taaggattct gaatctatct
    10801 gaatatttct acttaatcca ataatatgaa aaggctgcct caaaatagaa aatgaggcag
    10861 cctttttctg tattcttaag cagggatatt tactgaatat cccgaattga aagatgcagg
    10921 agactataat aaatccaaca tcagaggaat gtcctcttct cgaatccctt gtgtgagaag
    10981 agattcttca tctttgtgga acatctccaa gaatctttcc cggttcccac tagctgtaat
    11041 ggcttttccg tagaaaacgg cagctttctg aatatctccc attacccagg ccacatgccc
    11101 tgcgttcata taatcaatag ccagcggctt ttgtttaata atcttttcat aatatttcat
    11161 cgcctgttca tatttctgac tgatgaacga gcaccaaccg atgccgcgcc acgcctttat
    11221 acaattgttc tcgatgaaat ccaacttgaa gaaataattc agagcttcct catattgtcc
    11281 cagttcagct aggcaactac cgatatagaa agtcacattg gtatcttccg gagcagcttc
    11341 ttctaccttt ttataataag tgagtgcagc ctgatagttt ctgtttaacc ggtaacaaat
    11401 agccaggtgg cgattgttcc aaatattatc cggcttcagc gtgtctgctt tcagataagc
    11461 ctgaatagct tctgcatatt tctttctttt ctgtaatgca tagccaaact tctgataata
    11521 ttctgcactt tctccttcga atcctccaat agactccagt tcttcataaa tttcaatagc
    11581 ctcgtcccaa cgttcctttg ccagataaaa atcggcaatg gggaataata catcttccca
    11641 atacaagata ttgtcgagtg caggaacgtg atgaaggtcg agcttctctt taaaaatatc
    11701 tctgaactca ctcttgcgta cactaagttt gaagaaacgg tacaagtcgt gcaggtattg
    11761 gttactgacc gttcccggac gttcattgaa cctcttcatt gtttcaacat tcgatttctc
    11821 tgccaattct gccacctgct gttcgttcaa ctgactcaac atcatatctt gttgcgactg
    11881 tggcaattga tgaatcgtga aaaagagcga gtacttatcg ctgttgctga aaaatcccga
    11941 ttgaagaatt aaatccagca gactgcctcc ctgatttccc gcttgtttca ttgctttgag
    12001 tacattggac tgttgcttgc tgaatggata aaaccagtta tgcacctcgc ggaagaacgg
    12061 ataatttttc aatgcggcaa aagtgctcat atacacatct gcgccctcta attgcaattc
    12121 gttcatttca cgcaatttat ctcccaggcc ggacttctcg aacgcatctt cccaatccgg
    12181 gttcatatca ttgttttctt catcgttttc ttcaaaaccg aaccgcatat ttttcatgga
    12241 ggaaacattc ttcagcattt caggaataat ctcttccctc atctttttat caatcttttc
    12301 cgtttcctga cacaatagca tttggcggta aatacgtgcg acgtcttctc tgaatgaagg
    12361 tatttcctcc atgagatcta cccttttgat aagttccgga taaaaagaaa gacggcttct
    12421 gtagatgtgg aagataatca ttgtacctac caatgcccgt tggctgacgt tgacgttagg
    12481 gtgttcgtaa gcattgagca gccacattat ttttcgtaag tcgaaacatt ccatcaagct
    12541 caatgtgagg gcactgacaa ataagcataa gtcatctccc ggaagtaatt ccgaggcaag
    12601 catagctttt gcgtcttcct cgtcctcggg agtccatgca ctgtttgtcc atgttcttat
    12661 aaacataaac ttgagcgtat cttcatgccg tcttaatact tcatccatct tttcgtcaga
    12721 cagtaatccg ctgactgcca agtcgtcatt aaatgactcc aatatgtgta atattgtttt
    12781 gataccatag ttcgacaagt ccgccgatct gggagtgcgg cgtacctcat gataatatct
    12841 tgatgaagcg ttgtccaaca tgagcaaacg tgattggtcg gcaattcccc aggtgtctgc
    12901 taccattttt tgatacagat tccaccggtc agggtcgttt gctccctgtt tcatgtattc
    12961 cagcatatat ttgtaagagg tctgcaattg ttccaggcga gtgcgcaaat cccagtcagg
    13021 acactgccac agcaaagatt ccaactgcat taaggcttct ttgagtcttt tctcttcaag
    13081 taaagtacgt atatatgcgt attgttcatt aatcgttttt tcgttcatca ttctttaatt
    13141 atttattttt tccaatccag gtcaaacgtt tccagagacc ttcaaaagga ccgtgcttat
    13201 ggtgtcggag ccaccacgaa caaaatacca tttgtaatag aacaaaaagg atgccaaaaa
    13261 ggaaactgta agtgattcct aaatatcgtc caagttcaaa tccccaatga tagaacaaaa
    13321 gagaaccgaa aatagattgc ccgaggtagt tcgttaaact cattttacca taagatgtga
    13381 aacgcataaa gaaactgcgg tctttcacac ggtagaaagt cagcagtaat cctgttacca
    13441 gcaataccat gaagctaagg ctgctgaatg aacttaatat caattgcaaa ggaacaagga
    13501 tggcacttcg ttcgatgaat tccggcagca tattgttcaa tccgtagatg gggaagaagc
    13561 agagaagcga aacggccaat gcctttaacc acaggcgttc gttctgttcg ctgtacagga
    13621 aatatttgcg gcgaccgaca agcattccaa ataagaataa ccccggtgtc tgtaagatac
    13681 gtccatgttc cagtgcccag gtcatattgg ccagttgtcc ttcccacata ttcatgcgga
    13741 ctgtttcgag gaaagttccg ttcttttgta cgtcgaaagc aatgctgaaa taataacctg
    13801 ccaaactttt tcctgccaca tagtcagggt tacacaaagc ataaatcaat ttcacccagt
    13861 cgataggttg tagaattaat aaagtagcga agatgacaac cgtgcggtcg ctcatccggc
    13921 agaatatcgg aaggataatt cctaaaatcg catacatagt caatatttca ccggtaaaga
    13981 aagcggcatt gaactgtcct atcatgaaga gaatgaataa tctccataaa aaacgcaagc
    14041 ggaaatcttt ccctctccgt tgttggttgt tgtcttgaat gtagaaactg aaaccgaaga
    14101 gcagggcaaa cacagcgtat gctttgttac tgaatgtgaa gaataatcct ctccaaatag
    14161 cctgatcggt aaatttcatc cattcaaaag gtacttcttc cgggaaagag tagaaattaa
    14221 aatgttcaat actgtgtaag agaataattc ccattactgc taatcctctt aatacgtcgg
    14281 ccacgtctat tcgggcgttg gtttccgcga ttttgtgttc catgatttct tcgtttctgt
    14341 tatttataag attgatattc tataattatt tgattccgct gttttaatac tgctactcca
    14401 gccctaatac cggatgctaa tacttaattg atacttaatt taaaacctta cctgcacctg
    14461 tgcctgtatc agattggagt ctttttgtcc gtctcctttc ttgtcgcaaa aggtatattg
    14521 tgcttgtaag cggcatctag ggtagaacca gtattgtacg cctgcaatat agttattctg
    14581 tttgaaatca gcagctttgt tcggattgaa ataatcgaac gaagcgatga aatcgaaatt
    14641 ccgggcgaag cgtacactgc ctgttgcata gaaaccttcg cttttcacac tccggtcttt
    14701 tccggcaaga tattccgtac gcagattaaa ggtggaagtg gtgacaatcc ctcctgcact
    14761 ccagcgtttc ttggcgtaat tttctccggt tttaatttcg gtatattccg aatctgctat
    14821 ggcatgtcct gttccgcgga taaacgaacc acctacggat aaccatctca gcggattaac
    14881 catcaaatta ccgactacat ctttttgact gtttttgtct ttggtgttca atccttgtcc
    14941 gttcattaca gccactttgt attgcaggaa gtcacgaaat aattttccgt gaagcatcat
    15001 gccaatatcc cgtccggacg tcattccgta acacttatcg ctgccgctta ctcccgccag
    15061 ataacaaaca gactgtgaat aacaattgat gagctctact gtggtaggag ataattcatt
    15121 ttctatggta tagggaacct tgaattcacc gatacgtgcc gtaagtccgg ggagaaactg
    15181 ataatcggta tacacttcga gtaacatgcc cccattgtag aagtcataca taaaatcaca
    15241 agtccaccgt ttggtgatct ttccgtgtgc catgaaaatg attcgtttga tgtcgaatgt
    15301 attgtccggg ttcgctgcat cgtcataagt atatcccaat tgggcatatc cggagagact
    15361 aatccgttct ttcagtgtgt tgacaacttg atttagtggt gtctgctcct gtgccaggag
    15421 aggattttgc atacctgtaa tgcataatac aaaggttaag agttggagta gtgtttttcg
    15481 catgagttag ttgttatttg attttgatta tggttgatac tgtattatgg ttgatactgt
    15541 ggggatatac gttgtgtcaa tcagattctt ttcagagtag gtttcggg
//
