LOCUS       gnlProkkaEHCGDCHK_25   14062 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EHCGDCHK_25.
ACCESSION   gnlProkkaEHCGDCHK_25
VERSION     gnlProkkaEHCGDCHK_25
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 22:44:18
            Original ID  :: gnl|Prokka|EHCGDCHK_25
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 31322
            Orig. end    :: 45384
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14062
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14062
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14062
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2194..3162
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_29"
                     /sec_met_domain="PF04055 (E-value: 3.5e-18, bitscore: 57.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGFAAKQIASWLYEKKVASIDDMTNLSLKHRELLKQNYEVGAEA
                     PVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGCKMNCKFCMTGKQGY
                     TANLTASQIMNQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALELLTATYGYAWSPKR
                     ITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAFSITEMVELLKNYDF
                     SKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAIPGVDLEGADMDTMT
                     RFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
     CDS             3181..4221
                     /locus_tag="ctg25_30"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             4226..5320
                     /locus_tag="ctg25_31"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VVAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5330..6571
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg25_32"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6558..7085
                     /locus_tag="ctg25_33"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7091..7864
                     /locus_tag="ctg25_34"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             7871..8266
                     /locus_tag="ctg25_35"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPAAETPAPAAE"
     CDS             8515..9903
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg25_36"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_37"
                     /sec_met_domain="PqqD_RRE (E-value: 9.6e-11, bitscore:
                     32.8, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.4e-17, bitscore: 54.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQYEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(10370..10654)
                     /locus_tag="ctg25_38"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10691..11758)
                     /locus_tag="ctg25_39"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETMYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(11831..13342)
                     /locus_tag="ctg25_40"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
ORIGIN
        1 acgctcattt ccagttgaat ggcttttcac aggcggatgc caagtcgttc tcaaagcaat
       61 atttgtctac ttactccaag gctttgtctg cacagcagga agatattctt gcttcgtggg
      121 tgctggctga acaaccgcgc tgtttaagtg tattgctcaa cgagctggtt tcgttcggtc
      181 agtacgatgc tctcaatgaa tatatgcgtg gatattgccg gctcaatgag gttgggcaat
      241 tctatgacag tgtgctacgg cgtttgtcgg ctgattatgg ttccgaagag attggaagaa
      301 cgcttctgat gctttcactt actttagaag gatttaccga agatgaagtg aagagcatgg
      361 cagacattaa tcagatactt tggtcgcagt tgagagtgga aatgagcagc tggctcacca
      421 acaaaggagg acgatattgc attggtgata cacaaatggt agaggcgatc gaacgctatt
      481 tcgctcaaga tgacgaatgt atagatgata gtcgccatga aattatttcc gctctgctgg
      541 atgaggaaga aatcctttcc catccgttga cttttgccga ttataactat cgcatgaaac
      601 agttctgcta ccatgattcg tatcgctata aagtggagat tacctatcaa tgctataaga
      661 tgcaagaatg ggatatattg aaggattgga tttgtgatgt ggagattttc gagattctgt
      721 atcgcacgaa tcgttttctg ttggaagata gctggaaggc gatcatgaac gacaatcctg
      781 aagttacgcc tgaagtctat gccgaattgg actttgatga gatcgattct tttttaattc
      841 ctgtcattgc taatgatatg gctactttct tgagcagttc tttccatctg acgaaggcgg
      901 cagctgctgt gagtgagaag agtatggaag gtgctgccat gccactcatt gccaagtcgg
      961 tattgaagat gaatgaggga tgccggtatg cccgtaatga agagtacgaa acggcatgcg
     1021 actgtttcct gaaagcattg gtgatgcagg aaaacattgt gccgactccg gaactggaga
     1081 ttgccaatac ctgccgaaat ctagctctgg catattacta caatgagcaa tacaatgaag
     1141 cggcgatcta tttgaatagg gcgcttgatt atcatgcggc ttctgctgac gagaagagtc
     1201 aggcagaagt cattgaactt tccgaatatc tggcttattg tgattactat aaggatgagg
     1261 aagagagtgc tgccgagaaa ttccggaaag tagctgaaat gcacgagtca ttgaatggca
     1321 gactgtccgg tggagtggct aaatgtttgc gtatgcaggg taaatgtctt tattatatca
     1381 aacgatacga tgaagcatgg atgctgatga atcaggcgtt ggacattgct atacagatag
     1441 atagcaaaaa acagatcgtc gcttgtcata aacagttgta ttatctgtgc agggaattca
     1501 aacggatgat gaatgaacgt ggcgatgagc aggcgtctac tttattcttc cgtgagtctc
     1561 ttctgcatga aatgtatttc agcgaaaaac cgcgtctggc ggaactgact gtccgatatg
     1621 aggcattgag atgtgatatt atgcagcagt attacatgaa taaagactat gataacgtga
     1681 ttcgtattgc gacgtctttg gatattcacg atgatgctga ccctaatgct tcctgtctgg
     1741 tatattatta caaagcacag gcttatgtga agttggagaa ttatccaatg gcgaaagagg
     1801 ctttcttcag agaacttgaa ctgcgaaaga agtatttggg atgggaggaa gaagatacga
     1861 ttctggcttg tcagaactta ggggttttgc acagcttttg taatgaacgg gaagaggcgc
     1921 tggcttgttt ccgtgaggcg tacggttatg aagtgaaaaa gaatggcgag gattctgaaa
     1981 tggcgcaaaa gctacttcaa tatatcagcg tggttgaatc ataacggagg catacttccc
     2041 ttttttgtta acttttacat tcctgctata cggaaatcga ctttatttcc ttacatttgc
     2101 agatataaac tatcaacaga aagaagaatg tctaaatatc cccttttagg aatgactctt
     2161 gtagagcttc aatcattgac aaaaagactg ggtatgcccg gctttgctgc caaacagatt
     2221 gcatcctggc tttacgaaaa gaaggtagcc tcgattgatg atatgactaa tttgtcattg
     2281 aaacaccggg agttgctcaa gcagaactat gaggtgggag cggaagctcc ggtagatgaa
     2341 atgcgctctg tagatggtac ggtgaagtat ctttataaag tgggtgagaa ccattttgta
     2401 gagtcggttt atataccgga tgatgaccgg gcaacgttgt gcgtgtcgtc acaagtgggc
     2461 tgcaagatga actgtaagtt ctgtatgacc ggcaaacagg ggtataccgc taacctgacc
     2521 gccagccaga tcatgaacca gattcattcg ctgccggaac gggataaact gactaatgtc
     2581 gtaatgatgg gaatgggcga gccgctcgat aacctggatg aggtattgaa ggcattggaa
     2641 ctactgaccg ctacctacgg ttacgcatgg agtccgaagc gtatcacgct ttctacagtc
     2701 gggctacgga aaggattgca gcgttttatc gaagaaaatg actgccacct tgccatcagc
     2761 cttcactctc cgctgaccgt tcagcgtgct gaattaatgc cggcggaaaa ggcgttttca
     2821 atcaccgaaa tggtggaact gttaaaaaac tatgatttta gtaaacaacg tcgactttcg
     2881 tttgaatata ttgtttttaa agggctcaat gattcgcagg tctatgccaa agagttgctg
     2941 aaacttcttc gcgggctgga ttgcagggtg aatctgattc gttttcatgc cataccgggg
     3001 gtagaccttg agggggcgga tatggatacg atgacccgtt ttcgtgatta tctgacgtca
     3061 cacggacttt tcaccactat ccgttcatcc agaggcgaag atatttttgc cgcttgcggt
     3121 atgctgtcga cagcgaaaca ggagaaaaat aatgaaagtt aatatataaa accgaacatc
     3181 atgaaaaagt actcttttat tttatgcatc gctttggtag cctttgtcgt tgcatcttgt
     3241 ggtctgaaag gaaatcacac ctctagtggt cgtgcttacg agcttttggt tgtagtagat
     3301 cacggtgttt gggatcgtgc tgccggaagg gctttacatg atgcgctcga tgctgatatg
     3361 cccggtttgc cgcagtcgga accttctttc cggattatgt atacttcacc gaaagattat
     3421 gattctacgc tgaagttgat acgtaacatt attattgtag atatacagga tatatatacg
     3481 aaagcctcgt tcaaatatgc gaaggacgtg tatgccaatc cgcagatgat attgactatc
     3541 caggctccga acgaagaaga gtttgagaag tttgtggaag agaacaaaaa gacgattgtc
     3601 gacttcttta cccgtgcgga aatgaaccgt cagattacgt tcctggaagg gaaacacagt
     3661 aatttcattt cgcagaaagt ggacagtttg ttcggatgcg acatctgggt ggatgccgaa
     3721 ctggctaatt caaagaccgg ggatgatttc ttctgggctt ctaccaacac aggtactgcc
     3781 gaccgtaact ttgtgatgta ctcttatccg tacactgaca aggatacgtt taccaaagaa
     3841 tattttgtgc acaaacgtga ctccgtgatg aaagccaata tccccggatt caaggaaggc
     3901 gtttatatgt cgaccgatag tttgctgacc gatgtccgtc cgatcaatgt acagaacagc
     3961 tacacaatgg aagcacgtgg cctgtggcgt atgaagggcg actttatggg tggtccgtat
     4021 gtgtctcata ctcgtctgga cgagaaaaac caacgaatta ttacagcaga aatatttgtt
     4081 tattcacctg ataaaatgaa acgcaacctg gtacgccaga tggaagcatc tctgtataca
     4141 ctgaaacttc cgaatgaagt tcagcagaag cagattccat tgggagaagc atctaaggaa
     4201 gcggaacaaa ctaataaata aaaacatgga agataacaag ataaggatag gtatcaccca
     4261 aggagatatt aacggggtgg gctatgaggt gattcttaag acattttccg accctacgat
     4321 gttggaacta tgtactccga tcatttatgg ctcaccgaaa gtagtggctt atcatcgcaa
     4381 agcgctggat atacagacca atttcagcat tgtcaactct gctaccgaag cggggtacaa
     4441 ccgtttgagc gttgtgaact gtacggatga tgaggtgaaa gtggaatttt ccaaacccga
     4501 tcccgaagcc ggtaaagctg cgttgggggc tttggaacgt gccatcgaag aatatcgcga
     4561 aggattgata gacgttatcg taacagctcc gatcaacaaa catacgattc agtcggaaga
     4621 gttctccttc cccggacata cggaatatat cgaagaacgt ctgggcaatg gtgataagtc
     4681 attgatgatt ttgatgaaga atgacttccg ggtggctttg gtgacgacac atatccctgt
     4741 cagagagatt gcgactacga ttaccaaaga gctgattcag gagaaactga tgatattcca
     4801 tcgttgtctg aaacaggatt tcggtatcgg cgctccgcgt attgcggtgc tctctctcaa
     4861 tcctcatgcc ggagacggtg gtttgttggg aatggaagag caggaagtga ttatccctgc
     4921 catgaaagaa atggaagaga aaggaatcct ttgctacggt ccttatgcgg ccgacggctt
     4981 tatgggttca ggcaattata ctcattttga cggtatcctg gcgatgtatc acgatcaggg
     5041 gctggctccg ttcaaggcct tggctatgga agacggggtg aactatacgg caggactgcc
     5101 ggtagtacgt acttctccgg ctcatggaac ggcatacgat attgcaggta agggagtggc
     5161 ttgtgaagat tctttccgtc aggcaatcta tgttgccatc gacgtgttcc gtaatcgtca
     5221 gcgggaaaaa gtggctcgtg ccaatccgtt gcgtaaacag tattacgaga aacgtgacga
     5281 tagtgataaa ctgaagctgg atacagtaga cgaagattaa aaacgagtga tgacgaaagc
     5341 agagatacaa caagtgaaac agcgtttcgg tattattgga aatactgaag cattgtcgcg
     5401 cgccatagat gttgccattc aggtagctcc taccgatttg tctgtgctga ttaccggaga
     5461 aagtggagtc gggaaagaaa gttttccgca gattattcat caatatagcc ggaggaagca
     5521 cgggcagtat attgctgtca actgtggtgc tattccggag ggtacgattg attccgaact
     5581 gttcggacat gagaaaggtg cgtttaccgg tgcgattggc gaacggaaag ggtactttgg
     5641 cgaagctgac ggcggtacta tttttcttga tgaagtaggg gagttgccga tgtctaccca
     5701 ggcacgtttg ctccgtgtac tggagagtgg cgagtttatg aaagtaggtt cgtccaaagt
     5761 acaaaaaacg gatgtgcgtg tggtggcggc taccaacgtc aatctgacac aagcgattgc
     5821 agaaggacgt ttccgtgaag atttatatta ccggttgaat acggtgccta tccagatacc
     5881 gcctttgcgt gaacgtggtg acgatgtgct cctgttgttc cgtaagtttt ccgcagactt
     5941 tgcagagaaa taccggatgc ctgctattca gttgacggag gatgcgaaga aagagttgtt
     6001 ggcttacccg tggccaggaa acgtgcgtca gttgaagaat atcaccgagc aaatatctat
     6061 cattgaaacc aatagggaga tctctgctgc tatcttgcag aattatcttc ccgcacaaaa
     6121 tacgcaacgt cttcccgcgc tgatgggaac gcgtgagagt aaaggctttg agagcgaacg
     6181 ggagattctt tattctgttc tgttcgatat gcgccaggaa gtggcggagc tgaagaagat
     6241 ggtgcacaac ctgatggcgg aacgtgccgg acaggtgggg caggtaggac aaatgggaac
     6301 ggtggttact actccggtag tgacggcgca tcaaccttcg gtacctgcta tcattcacac
     6361 catgcagcct acggtttgca aggatgatga tgacatacaa gacacggaag aatatgtaga
     6421 agaatctcct ttgtcactgg atgaagtgga gaaagaaatg atacgcaagg cacttgagag
     6481 gcatcatgga aagcggaaga gtgcggccaa ggacttgaat atttccgagc gtacacttta
     6541 tagaaaaata aaagaatatg aattggatta agaaaataat acgccctttg ttactgttcg
     6601 gcttgccgtt ggtagtcatt gcgtgcactg tttcctataa gtttaacgga tcgtctatca
     6661 attatgataa ggtaaagacc atttcgatag ccgacttccc gatcaagtcg gagtatgtat
     6721 atgctccgtt ggcaaccaaa ttcaatgagg acctgaaaga tatcttcatc cggcagaccc
     6781 gtctgcaact gctcaagccg aatcagaatg cggacttgca gattgacgga gaaatcacag
     6841 gatacaatca gtacaaccag gcagtatctg ccgacggtta ttcttcggag acgaagttga
     6901 ctattaccgt caatgtacgt tttgtcaaca acaccaatca tgccgaagac tttgaacaac
     6961 agttttctgc gttccgtacc tacgactcta gccagttgct gactgccgta caggacggat
     7021 tgattgctga aatgtctaaa gagatcaccg accaaatttt taatgcaact gtagcaaact
     7081 ggtaatataa atgacttctg ttaactttca acaatggatt cagcatcccg agacgctgaa
     7141 tagggatact ttgtacgaac tgcgcaatct tcttgcgagg tatccgtatt ttcagtcact
     7201 tcgtctgctg tatctgaaga atctgtatat tctccatgat attagtttcg gtggagaact
     7261 gcggaaagca gttctttaca ttgcagacag acggcagttg ttccggttga ttgaaggtga
     7321 ccgctatgat gtgcaggcac ggaaaaaggg agtacctctc acggaggtac tgaaagacga
     7381 accgtccgta gaccgcacat tagcattgat cgacgctttc ttgtccacag tacccgaaga
     7441 ggtgactgcc cgcaccagct tcgactattc gatggattat acctcttatc ttttggagga
     7501 gactccggcc acggaacagt cggccgaaga aacgcccaaa ctcaaaggct acgaactgat
     7561 tgacgacttt atagaaaaga gcgagagcga ctctcccctc tgcaagaaac ctttaagaga
     7621 agaaatgcca tcttcgccaa cctcttcgga cgaacttacc gaagaagaaa cgatgaagga
     7681 agaagaggaa gatgacagct gttttacgga aactttggca aaaatctatg ttaaacagca
     7741 acgatattca aaagctcttg aaataattaa aaaattaagc ttgaaatatc caaaaaaaaa
     7801 tgcttacttt gcagaccaaa tcagattttt ggagaaattg attattaacg ctaattcaaa
     7861 ataactaaaa atgtacttat tattcgttat cttaatggtt attgcagcct tgttgatgtg
     7921 tttcatcgtg ctgattcaga actcaaaagg aggcggactt gcttctggtt tctcttcatc
     7981 taacgccatc atgggcgtgc gcaagactac agattttctg gaaaaagcaa catggggctt
     8041 agctatcttc atggtggtaa tgagcattgc tactgcttat gtagttcctc gctctgctgt
     8101 tgctaaagac gcagtgttgg aacaggcaca gaaagaacaa cagactaacc cgtataactt
     8161 acccgcaggt acggctgcgc cgcaaactga agctcctgct accaatgcac ctgctacaga
     8221 aactccggca ccggctgctg aaactcctgc tcctgcagca gagtaattca ctctgtcgtc
     8281 aggtaagact ttggggtaaa accattaatg ggaaggtgca gacggatgct gcatttcttt
     8341 gatatttaag tgcggattac gcagattaca cggattttca atcttccgcg tggtcagtgt
     8401 aatccgcact taactttttc ttgtaaaaac aatctctttt tgatagaaac aaacgagatt
     8461 taactacctt tgttggtcgt atgaagatta ttaactactt ttttaaatat aacaatgaca
     8521 gaacatttga aacagaaatt gaatgactcc gccgtactcc gatggagtgt tctagcattg
     8581 gtcgcattta ctatgctatg cggctatttc ctcaccgacg taatgtctcc tctaaaaccc
     8641 atgcttgaga aagaactact atgggacagt cttgattatg gtttcttcac aagcgcttac
     8701 gggtggttta atgtattcct attgatgctg attttcggtg gtatcatttt ggataagatg
     8761 ggagttcgtt tcaccggaat gggggcttgc ttattgatgg tgtttggttg tggattgaaa
     8821 tactatgcga tttctactac ttttccggaa ggtgccatgc tctttggatt caaaacacag
     8881 gtaaccctgg ccgcattggg gtatgctatc ttcggtgtag gtgtggaaat tgccggtatc
     8941 acagtttcca aaattatcgt aaaatggttc aagggtaagg aaatggcatt ggctatggga
     9001 cttgaaatgg ctacggcacg tatcggaaca actctggcaa tggtgctcac ggttcctttg
     9061 gccgacttct tcggatctac ggatgagagt ggcacattcc ataccaatat tcctgctccg
     9121 attttgtttt gtctgattat gttgtgcgtg ggtacgattg ctttcttcct ttatactttc
     9181 tatgataaga agttggatgc ttctttggat gcagagggat tggaaccgga agaaccgttc
     9241 cgtatgaaag atattgtgta tatcattacg aataagggat tctggttgat tgcattacta
     9301 tgtgtattgt tctactcggc tgtattcccc tttatcaagt atgctgccga cttgatggtg
     9361 cagaagtata atgtagatcc gaagttggcg ggaacgattc ccggattgtt gccgattggt
     9421 gcgattatcc tgactccgtt gttcggctcg ctttatgacc gtatcggtaa gggagctacg
     9481 ttgatgataa tcggatcagt gatgcttatt tttgtgcata cgatgtttgc tctgcctata
     9541 ctgaatatat ggtggtttgc tactatcatc atgattatat tgggatttgc cttctcgttg
     9601 gtgccttcag ctatgtggcc gtctgttccg aagattattc cggaaaaaca gttgggtaca
     9661 gcatacgcat tgattttctg ggtacagaac tggggattga tgggtgttcc tttgttgatc
     9721 ggatgggtgt tgaatactta ttgcaaaggt ccggtagtag acggtgcaca gacttatgac
     9781 tacacgttgc cgatggctat ttttgctctc tttggtgtgc ttgctctgat tgtggctttg
     9841 atgttaaagg cagagaacaa gaagaaggga tacggtctgg aagaggcgaa tatccaaaag
     9901 taactaggaa attcaatacc taaagtgaca aaggaatttt gtatcaaggt gtaaacagaa
     9961 gagtatcagt atgaatactc tgaaataaaa aataagaagt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacaattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtgcc
    10141 gaaaggaatg tcgaaagaac ttcatgtgaa attggaagaa cacggtacgg ctgtatggga
    10201 actgatagat ggaaaacgca atgttcgtga gattatagaa aaactcgcag accactttca
    10261 atatgaagag ggctacgagt cgcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 atttataaaa ctggtgatac cagtcgtata aataggaact tattattatt tatttgataa
    10381 atacagccca aagtatgacg gcaattgcta tcaggacccc catgataata agcgttcccc
    10441 aaacaaaata attgctgtct ttctctttct ttttctccga gtcgtggatg atacgttcca
    10501 tttcttcggg ggtggtgttg ggtagtggat aaggttcgtt tgcacggttt agatgcttca
    10561 acttatcgtt agcacgttca cgacgtaggc gggaagcttc ccgtccctct tttattcggc
    10621 gtatcatgtc gaatgcatgt ccttcaccaa ccatattctt tgttttttag aagttcactt
    10681 cctcgttttt ctatttccct tcttctctgt ccactttgag caatcctccc gtattcggat
    10741 caaaataaac tttgatggta gaattcttgt tgaacaaaac cggagccaga tattctatca
    10801 caccaaattg agtaatagga agttcacctt cgtaaagttt ctttttgccg tcggtcaatg
    10861 taaccatagc ttgtccgggt acgttgtagg cgattccatc caaatctttc ttcttcttac
    10921 cgtcttcctg tggtattttg accgatttca ggtctttcag actgatataa aacggagttc
    10981 ctgccaaatc attgttggca actacaccta acttcttcga gaagcggaag gcaacttcat
    11041 tgttgaattc cttgtcaggg gtaaggcgga cagtgaatgt tctttcttct ttgttgcagg
    11101 tgccggagaa catttgtgtc atggcttctt cctgtgcatt cagattgtcg agcataatct
    11161 taagctgtgc cccatctgaa ggcatattat cagcttgtcc gcgcaataag gcatttttgc
    11221 tttcgcggat attatagatt tctttagcca ccagctcggc catcttggcg gtagaactag
    11281 ccatcagaat ctcttcggtc aggaattcgc gaggattcgc tttcttttgg aggactgcgg
    11341 gggcgggagc agctttttta cctacactgc tattgctgta aggaacattg atcgttttca
    11401 caatgccatc ctctgtcagt tccatgagcg gtgctactgt cttatccttc aattttacga
    11461 aatacatagt ttcgctgttg ggcacaccta cggatttcac ttttacgcta gccagttccc
    11521 agtactcttc agggtcggcg gagacgttgg tcagtcgcag gtaacgatca gcatatttgc
    11581 tgaattctcc cggagtatag ttgactttgt tggcttttat ttcaagttct atttgggttt
    11641 tgggaagact gtaaaccact ccatagtctt ttcctcgggt aacccctgtc agtacttcgg
    11701 tttgtgcata ggcggacgtt gtcataagta gtcctgctgc tataatcaac tttttcatat
    11761 tcggttcttt ttaactggtt ttgaaaacaa agttaatgaa gttattgaaa aaactgtaag
    11821 ttcttaactt ttattcgctt acaagtcgcc atgctgtcgg cagacaggtg ataatatcgc
    11881 ttgcgatcat tccgatcatt ccttgcttct tttgagcgac atcgcccgcc aatccgtgaa
    11941 tgtaagtgcc gattttagcg gcttcctcgg tggggtaacc ttgggcaagc agtgccagga
    12001 ttactccggt cagtacgtca ccgctacctc cggttgccat tcccggattt ccggttgggt
    12061 tgaagaagca tttaccttct ggggtgatga tggcggagta ggctcctttt aaaataatgt
    12121 gaacatgggc ggcacgagcc aattcgcaag ccttcatcag acgttcgtaa gagtcctggc
    12181 atttgccggt cagacgttcc agttctttcg gatgcggggt gaggatggaa cccttcggca
    12241 ggtgggtaag ggcatggcgg tggttggcaa ggatattaag tgcgtcggca tccaccacaa
    12301 caggagtctg gcaatgttcc agttgctcca ataaagcagc ttccgtttcc tcgtttcgtc
    12361 ccagtcctgg gccgatgccg actgcttgat agtcgtccgt gtcggtaggt acggcaaaac
    12421 aggtttcgtt gatgtcggtt tctacgattg cttcgggtat ggaggtttgc aagatgtcgt
    12481 tgttgcacat tggcgcatgg acagtcagca accctactcc cgaacggagg caggcgcggg
    12541 cagcgagaac agaggctcct gccattcctt ttgaaccggc aatcaatagt gcatggccga
    12601 agttcccttt gtgggcaaac tgtttgcgtg gcttgatgag tgaacggatt tgctctattt
    12661 ccaacatttc gtagttagtc tccatctctt caataccgtc ttcgctcaat tggatatcca
    12721 gcacttccca ttctccgaca aattccgtgt tctctgcgaa aagaaaggcg agcttcggca
    12781 gttgcagact gaaagttacg tcggcacgga taatattagc ttttacgttg aatgtatttt
    12841 cttctcccat cagtccggaa ggaatgtcga tggctactac catggcaggg gaggaattga
    12901 tgtatttcac tacggcagcg aatccgccgc tcaacggttt gttcagacct gaaccgaata
    12961 atccgtcgat taccagatgg tcgggcgtca gggcgggagg tacgaattgg gtactgatct
    13021 cgtggaattt tacttcttcc atcatttcta ccagttcttt attggtctgg cagtcgggtg
    13081 aaagttctcc ttttgtgttg aagagaaata cctcgatttt atatcctttt tcagccatca
    13141 tgcgggctac ggcgagagcg tctccgccat tattccccgg tccggcaaag atagtgaccg
    13201 gcgtttccgt attccatctg tctgtgatgg cttttgttaa tacggttgct gcacgttcca
    13261 tcagatcgat tgatgcaata ggttcgttct caatggtata agcgtccaat ttcttgatac
    13321 tgctgcttgg aaatattttc attgcgatgt tcttttagtt ttcggattac aaatgtacat
    13381 gattcttctg acttttcccg tttgttgtgg gaagaaaact tgttaatcat aaggagatga
    13441 cttgttgggg gcagggaaat gaatcaaatt cgtggtggtt tgatttatta aaaataatca
    13501 ttttgtacct ttcacaagtt tcacggacac gtaagttgta gtgtgacaga tgtttgttgt
    13561 gatttaaggt tctcttttta acccttcaca tctttcacac tgttcgcgcc cttaagaaag
    13621 aagcccggtc aaaacaaaag cttaggtgtt tcttcaatat ggaaagacat aggagaacga
    13681 atatgattga agaccggatt gaaatagttg gcatgatatt agccaactgt agttggctac
    13741 ttagatgact actgtcggct acatggtcga ctggagttga ctaagtagct gacttcagtt
    13801 gtctattaat aacccaactt caaaattgtc gtatagtgcc gacattaggc actattaagc
    13861 tatatgcctc atgtgtggtt acggtttcct tcatcttcat accttcttga acaaactttt
    13921 gatacgcccc ctcccctgat taagcctttg attatttgcc gtttccgata aaaatgttat
    13981 ctttggagat agataatgtg catcacatgg ttcttcgtca aatttggtgg tacttcttct
    14041 attgtgaata aagaatcttg gc
//
