LOCUS       c00059_gnlPro..        13357 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KBBFNAGN_59.
ACCESSION   c00059_gnlPro..
VERSION     c00059_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 00:11:57
            Original ID  :: gnl|Prokka|KBBFNAGN_59
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13357
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..921
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.9e-48, bitscore:
                     153.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GMHGNLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHF
                     DIDPAEIDKNVKTDVAVLGDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPE
                     LHPAGKALSMGEVVRAVSEATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTM
                     GFGLPAAIGATFGRPDRTVCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVR
                     QWQAMFFNRRYSFTPMMNPDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEA
                     CVEEEGNVMPMTPPGGSVNQMLLEC"
     protocluster    1..13357
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:3357]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..3357
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13357
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13357
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             954..1514
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_2"
                     /sec_met_domain="ALS_ss_C (E-value: 1.1e-19, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             1511..2263
                     /locus_tag="ctg59_3"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             2314..3357
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_4"
                     /sec_met_domain="IlvN (E-value: 7.1e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 6.2e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(3419..5332)
                     /locus_tag="ctg59_5"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     VARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NAELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCYEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     IGGNRILEEKIDIGIISPYKAQVQYLRSKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRTNEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRRLLEFIQNIG
                     NQ"
     CDS             5447..7690
                     /locus_tag="ctg59_6"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDIVTATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGRE
                     EVVKMAASVAADLRADDEVLANPEKYYDRIIEIDLSLLEPYINGPFTPDAATPISKFAE
                     VVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASPLIVNPGSEQIRA
                     TAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDDPERKNSIVTSFNRNFAKRADGNP
                     NTFAYVASPEITMALTIAGDLCFDPLRDTLVNAKGEVVKLSEPVGEELPAHGFIGGKEG
                     YIAPGKGQTEITVNPHSQRLQLLTPFPAWDGMDLLNMPLLIKVQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNKVWNRSTNTYGTVSGTAKLYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFTDKADYDKIRERD
                     LISVMGLKDFAPGRTLKVVLHHEDGSKESFEVQHTYNEQQIAWFRAGSALNAR"
     CDS             7694..8854
                     /locus_tag="ctg59_7"
                     /transl_table=11
                     /translation="MEKITVPFITGDGVGAEVTPSMQAVVNAAVKKSYGDRRGIEWKEV
                     LAGERAFHETGSWLPDETMEAFRTYKVGIKGPLTTPVGRGIRSLNVALRQTLDLYVCQR
                     PVRWYKGIVSPLKEPQKVDMCVFRENTEDIYAGIEWEAGTPEAEKFYRFLHDDMGVTKV
                     RFPETSSFGVKPVSREGTERLVRAACQYALEHHLPSVTLVHKGNIMKFTEGGFKKWGYE
                     LAEREFGKELAEGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGG
                     IGIAPGANINYKTGHAIFEATHGTAPNIAGKDIVNPCSIILSAVMMLEYLGWKEAASLI
                     EKALEQSFTEARATADLARFMPGGVSLSTSTFTREIVRRIENGNNE"
     CDS             8867..10210
                     /locus_tag="ctg59_8"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEDLKEATRIENELFRKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVDDLAHAIIKEKRFGFEEIAYLLLSGRL
                     PDKEELSSFRELINDNMPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPDADDTSRD
                     NLMRQSIELISKFPTIIAYAYNMLRHATHGRSLHIRHPQENLSIAENFLYMLKKDYTEL
                     DARTLDLLLVLQAEHGGGNNSTFTVRVTSSTGTDTYSSIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIQDWTNVDEIDTYFTRMLNKEAYNKTGLIYGIGHAVYTISDPRAILLKEL
                     ARDLAREKGKEREFAFLELLEERAIDVFGRVKNNGKTVSSNVDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDEVTYVPIKKR"
     CDS             10459..11229
                     /locus_tag="ctg59_9"
                     /transl_table=11
                     /translation="MNQETFQIFLWVMSAVALAVFIALYFVKAGYGMFRTASWGISINN
                     KLAWVLMEAPVFIVMFGLWGKSGAGFTVPVYFFFLLFQLHYLQRAFIFPFLLKGKSRMP
                     VAIMAMGIVFNLLNGMMQAGGLFYFALEGLYADGWAYLLKPHALLGVILFFAGMFINLH
                     SDYVIRHLRKPGDTKHYLPGKGLYRYVTSANYFGELVEWTGFAILTASPAAWVFVWWTF
                     ANLVPRADAIHRRYREEFGDEAVGKRKRIIPFLY"
     CDS             11309..12532
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Oxidored_FMN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg59_10"
                     /sec_met_domain="Oxidored_FMN (E-value: 5.7e-51, bitscore:
                     163.9, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESKLFTPVTFGPLTLRNRTIRSAAFESMCPGNAPSDMLLDYHRS
                     VAAGGIGMTTVAYAAVTQSGLSFDRQLWMRPEIIPGLRRLTDAIHAEGAAAGIQLGHCG
                     NMSHKSICGCMPVGASSGFNLYSPTFVRGLRADELPEMARAYGRSVNLAREAGFDSVEI
                     HAGHGYLISQFLSPSTNHRKDEFGGSLQNRMRFMDMVMEEVMKAAGSDMAVLVKMNMRD
                     GFRGGMELDETMQVARRLEQSGAHALVLSGGFVSKAPMYVMRGEMPIRSMTHYMTCWWL
                     KYGVRMVGKWMIPSVPFKEAYFLEDALKFRAALKIPLVYVGGLVSRDKIDEVLDDGFEA
                     VQMARALLNEPGFVNRMRAEENARCNCRHSNYCIARMYSIEMACHQHLKEELPPCLKKE
                     IEKIEAKG"
ORIGIN
        1 ggtatgcacg gtaacctggg gcccaatatc aataccaata aatgtgatgt ccttatcgcc
       61 gtaggcatgc gctttgatga ccgtgtgacg ggtaaattgg aaacatatgc caagcaggcg
      121 aagattatcc actttgatat tgaccctgcc gaaatagata agaatgtaaa gaccgatgtt
      181 gctgtcctgg gagattgcaa agagacactg gctgccgtta cccaattgct ggaacccgcc
      241 aaccatcagg aatggattga cagtttccgg caatacgagg aagtggaaga ggaaaaggta
      301 atccgtccgg aattacatcc ggcaggaaaa gcgctaagca tgggtgaggt ggtgcgtgct
      361 gtgagtgagg ctacccataa cgaggcgata ttggtgactg atgtcggcca gaatcagatg
      421 atgtccgccc gttatttcaa atacagcaag gaacgtagca ttgttacttc cggtggcctg
      481 ggtactatgg gcttcggcct tccggcagct atcggtgcca cttttggacg tccggaccgc
      541 acggtatgcg tattcatggg agacggcggc ttgcagatga acctgcagga actgggtacc
      601 atcatggaac aaaaggctcc ggtgaagatg attctgttga acaataactt cctgggcaat
      661 gttcgtcaat ggcaggcgat gttcttcaat cgtcgttatt cgtttactcc gatgatgaat
      721 ccggattata tgaagattgc ttcggcatat gatattcctg cacgcagggt aatgacccgc
      781 gaggagttgg caaaagcgat tgacgagatg atagcaaccg acggaccatt cctgctcgaa
      841 gcttgtgtgg aggaagaagg aaatgtaatg ccgatgacac ctccgggcgg ttcggtcaat
      901 cagatgttgt tggaatgctg aagtcatgcg aaattaaaga atttactcta tctatggata
      961 aaaaactata tacaatcatt gttcattcgg aaaactttgc cggtttgctg aatcaggtga
     1021 cggctgtgtt tacccgccgg cagataaaca tcgagagttt gaatgtatcg gcctcctcca
     1081 tcaagggggt acataaatat accattaccg cttggacgga caaggatacc attgaaaagg
     1141 tgaccaagca gattaccaag aaaatagatg tgctgcaagc ccattatttc acggatgatg
     1201 aaatctatca gcacgagatt gccctttata aaataacgac ccctacgctg gaagaaaaac
     1261 cggaggtgtc caaagtaatc cgtaagtaca atgcccgtat tgtggaggtg aatgctgtat
     1321 ttgccattgt tgagaagaat ggcatgagtg aggaaataac caatctttat gaggagttgc
     1381 gccagttgga ttgcgtactt cagttcgtcc gttcgggtcg cgtagccatt acgaccagct
     1441 gctttgagcg tgtcaatgaa tatctggcgg accgtgaagc aaaatatcgt caaagtaaac
     1501 accaggaatc atgatgagcg agaacaataa aataggtacc tacaagtttg ttgccgaacc
     1561 gtttcatgtc gactttaccg gacggctgac aatgggagta ttgggcaacc atttgttgaa
     1621 ttgtgcgggt ttccatgcca gcgaccgcgg ttttggcatc gcgactctaa acgaggacaa
     1681 ttatacttgg gtattgtccc gtctggctgt cgaactggat gaaatgcctt atcagtacga
     1741 agatttctcc attcagactt gggtggagaa tgtctatcgc ctttttacag accgtaattt
     1801 cgctatcatc gataaggagg gcaagaagat tgggtatgca cgttccgttt gggcgatgat
     1861 tagcatgaat acccgtaagc cggcagattt gctggctctt catagtggca gcattgtaga
     1921 ttatgtttgc gatgagcctt gcccgataga aaaaccttcg cggataaagg tggcctcaaa
     1981 ggaaccggtt gctgctttgg tagccaaata cagtgatatt gacattaacg ggcatgtgaa
     2041 cagcatccgt tacattgagc atatccttga tttgttccca atagagatgt ataaggagaa
     2101 gcgcatccgt cgttttgaaa tggcatatgt agccgaaagc tattatgggg atgagttgac
     2161 tttgttcatg gatgatgccg gtgagggcgt ttacgatgtg gaggtgaaaa agaatggcag
     2221 cgaagtggtc tgtcgctcta aagtgatatt tacagagaaa taaataaatt tatcaacgtt
     2281 ggcgtaagcc acaaataaaa attaaaacaa aaaatggcac aattgaattt tggcggtgtt
     2341 attgagaatg taatgacccg cgaagaattt cctttggaaa aagcacgtga gattttgaaa
     2401 gatgaaacaa ttgcagtaat tggttatggc gtacaaggcc cgggccaggc ttgcaacctg
     2461 cgtgataacg gtttcaatgt gattgtagga caacgtccgg gcaagacata cgaaaaggcg
     2521 gtggctgacg gatgggtacc gggtgagact ttgttcggca tcgaagaggc ttgtcagaaa
     2581 ggtactatcg tcatgtgtct gttgtctgac gcagctgtaa tgtctgtatg gccgactatc
     2641 aaaccttatt tgactcccgg aaaggctctt tacttctctc atggttttgc tattacctgg
     2701 aacgaccgta ccggcgtggt tcctcctaaa gatattgatg ttattatggt tgctcccaaa
     2761 ggttccggta cttcacttcg taccatgttc ctcgaagggc gtggcttgaa ctcatcatat
     2821 gccgtctatc aggatgctac gggtaaggct tttgacaaga cgattgcact gggtatcggt
     2881 attggttcgg gatatttgtt cgagacaact ttcatccgcg aagccacttc cgacttgacc
     2941 ggtgaacgcg gttcattgat gggtgctatc cagggattgc tgttggctca gtatgaagta
     3001 ttgcgcgaaa acggccatac tccttctgaa gcattcaatg aaacagtgga agagttgact
     3061 caatctttga tgccattgtt tgccaagaac ggtatggact ggatgtatgc caactgttct
     3121 actacggcac agcgtggtgc gctggattgg atgaccccgt tccatgatgc catcaagccg
     3181 gttgtacaga aattgtatgc aagtgtgaag tcgggcaacg aagctcagat ttctatcgac
     3241 agtaactcca aacccgatta tcgtgagaag ctgaatgcag aattgaaagc cttgcgtgaa
     3301 agcgaaatgt ggcagacagc tgttacagtt cgtaaacttc gtccggaaaa caattaatca
     3361 gctttatata aataggtgaa ataccctctt cggtgttacc ggagggggta tttctttatt
     3421 attgattccc tatattttga ataaactcca atagcctccg gtaaaaaccg tgatgtttca
     3481 gcgtctctgc ctctcccaat atcaccagct tcatacgtgc ccgggtgatg gctacattca
     3541 ttctccttaa atcattcagg aatcctatct gtccttcttc gttggtacgg acaaggctga
     3601 tgaagataac atcgcgctct tgcccttgga agccatccac cgtatttaca gtgaacaagc
     3661 tgcgataagg cttgagtgaa gcgtctgcct ttatcttgct gcggagatat tgcacttgtg
     3721 ccttgtaagg ggagatgatg ccgatgtcta ttttttcttc cagaatgcgg ttgccaccga
     3781 tacggttgat gtagattttc agttctgata ggagcaggtc cgcttccgcc ttattaatgc
     3841 gtccgaaagt ctctcccaca aattcttctt tgaaatccat ttcggaggtg tcaatccagt
     3901 ggatgggggt atcccagtcc aggatgcccc ggtaacgcac ttcgggagcg gcttccaact
     3961 cgccattata aaaccattgg gaaggaaatt tcatgatttc ctcgtgcatg cggtattgta
     4021 ctttcagcaa agagacaacg gcaggtttgt tggacaccac tttctccatc aatgttcgtt
     4081 ccagacctcc acgggcagct tcgtagcatt ttatggtggg cggaagttgg cagtggtcac
     4141 ccgccaatac cacgcggtct gcttttcgga tagctatcca gcaggcagct tctaaggcct
     4201 gggctgcttc atcaatgaaa agggtgccga aacggcgtcc gttcagcagc cggtgattgc
     4261 tgcttactag cgtggaggct atgacatgtg ccccatcaaa aagctctgca ttgatttgta
     4321 tttccaatgc ggtggcgcgg tcgcgcaggc ggctcatacg gctgcgtact ccttcgcgtt
     4381 cgtcatagct gccacggcgg gcacggctgc ccagttcacg gagatttttc cggatgctcc
     4441 acagctccgg ataaagcgga tggttctcga aacgacgctc gtaggtaaag gaaagcatct
     4501 tgtcgttgac acgggtcgga ttgccgatac gcaggacatt gacgccacgg tccacaagtt
     4561 tttccgaaat ccagtcgacg gcagtattgc tttgggcaca taccagtacc tgcggttccc
     4621 gatgcagggt ttcgtagatg gcttccacta aggtggtcgt ttttccggtt cccggaggac
     4681 catgtacaat ggccacgtcg cgagcacaca gcactttgtt tacagctgtt tcctgcgtgg
     4741 agttcagcca gggaaaccgt acgggataga gctctcggaa accggctttc gaggttccca
     4801 gcaatatgtc ccgcaattcg gccaggcggt tgcctttgga gcgtaacgta tcttccaagg
     4861 cttcgaacat ggtccgatag gatgtttcgt cgaaataaag ttgcacgccg aggttgtccg
     4921 tttcctgcac ttccatcacg gcaccggctc cgggcattat cgctaccatc cgtgtctcgt
     4981 cggcatagct tacggtagcg gtgaagttca tataggttat ttttccatcg gcagactggc
     5041 ggaaaaaaca tacgggacgg ccgaactcaa aattatgttc tatatcggta ttttctgtgt
     5101 gtgtaatttc tattactaat tgattcagtg aattatagta acttcgtccc ggagtggcag
     5161 gataccagca aagtccccgt ttcactttcc gggcaacccc catgttttcg gtttggcgtt
     5221 tgaattcctc tttttcgtat tcgtattcca tgcgcagcaa aagttgctgc tgttggaggt
     5281 gaataatagg actatttgaa tcttgttcct tcatggttgc aaaggtaatc attcttcgct
     5341 tccgacggaa aaaatgcttt attttgttaa actattcagc ctttttattt gtttatgata
     5401 ttaatttgta atctttacaa taatgaaaaa ctaaaaaata gtggttatgg tatatgattt
     5461 aacgatgctc aaaacgtttt atgccgctta ttcggagaag atagaacgcg tacggaacgt
     5521 actgcggcgt ccgatgactt tagcagagaa aattttgtat gctcatttgt atgatgggga
     5581 taaagtgaag aactacagac ggggagaaga ctatgtgaat ttccgtcccg accgtgtggc
     5641 catgcaggat gcaacggctc aaatggcctt attgcaattt atgaatgcag gccgtgagca
     5701 ggttgccgtg ccttccactg tgcactgtga ccatttgatt caagcatata aaggtgcaaa
     5761 agaagatatc gtgactgcta cgaagaccaa cgaggaggtc tataattttc tccgtgatgt
     5821 ttcctcccgc tatggcatag gtttttggca gccgggagca ggcattattc accaggtggt
     5881 attggagaac tacgcatttc cgggtggaat gatggtaggc acggactctc atacgcccaa
     5941 tgccggaggt ttgggcatgg tggccattgg tgtgggtggt gccgatgcgg tggatgtgat
     6001 gaccggcatg gaatgggaac taaaaatgcc gcgtctgata ggcgtacact tgaagggtaa
     6061 attgagtggc tgggtagctc ccaaagatgt tattctgaag ttggcgggta ttcttactgt
     6121 aaaaggggga accaatgcca tcattgaata ttttggaccg ggaaccgctt cattgtctgc
     6181 cactggaaag gctaccatct gcaatatggg ggcagaggtg ggggcgacta cctccctttt
     6241 cccttacgat gagcgcatgg gtacttattt gaaggctacc ggacgtgaag aagtggtaaa
     6301 aatggctgct tccgtagctg ccgaccttcg cgccgacgac gaagtgctgg caaatccgga
     6361 aaaatattac gaccgcatca ttgaaataga cctctcgctg ttggaaccgt atatcaacgg
     6421 gccctttacg ccggatgcag caacaccgat atcgaaattt gccgaggtag tgataaccaa
     6481 taactatccc cgccggatgg aagtcggcct gatagggtcg tgcaccaatt cgtcctatca
     6541 ggatttgagc cgcgcagcct cccttgcccg gcaggtaaag gaaaagaatt tgaaggttgc
     6601 ttctccgctg attgtcaacc ccggttcgga gcagatacgt gccactgctg aacgcgacgg
     6661 catgattgcc gctttcgaag atattggtgc aacgataatg gcgaatgcct gcggaccttg
     6721 tattggccag tggaagcgcc atactgatga ccccgaacgc aaaaattcca tcgtcacctc
     6781 ttttaaccgt aattttgcca aacgtgccga cggaaatccc aacacttttg cttacgtcgc
     6841 ttccccggag ataacgatgg cgctgaccat tgccggtgac ctttgtttcg acccgttgag
     6901 ggatacgctg gtcaatgcca aaggagaggt tgtgaaactg tccgaaccgg tcggtgaaga
     6961 actgccggca cacgggttta taggaggaaa ggaaggatac attgctccag gcaaaggaca
     7021 gacggaaatt acggtcaatc ctcattcaca gcgcttgcaa ctgctgactc ccttccctgc
     7081 ctgggatggc atggacttgc tgaatatgcc tttattgatt aaagtgcaag ggaaatgtac
     7141 caccgaccac atctctatgg cggggccatg gctccgtttc cggggacatt tggagaatat
     7201 ttcggacaat atgctgatgg gggctgtcaa tgctttcaat ggagagacga acaaggtttg
     7261 gaaccgctcc accaatacct atggaacagt gtcaggcact gcgaagctgt ataaatctga
     7321 aggcatccct tccattgtcg ttgccgaaga gaattatggt gaagggtcca gccgtgagca
     7381 tgctgccatg gaaccacgct tcctgaatgt acgcgtcatt ttggcgaaaa gctttgcccg
     7441 tatccatgag acgaatttaa agaaacaagg catgttggcg ctgaccttta cggataaggc
     7501 cgattatgac aagattcggg aacgcgactt gatttctgtc atggggttga aagattttgc
     7561 tccgggacgc actttgaagg tggttcttca tcacgaggac gggagtaaag aaagttttga
     7621 agtacaacat acgtataacg aacagcagat cgcttggttc cgggccggtt ctgcacttaa
     7681 tgcaagatag aatatggaaa aaattactgt accttttatt accggcgatg gggtgggagc
     7741 agaagtgacc ccatccatgc aggctgtcgt gaatgccgct gtcaagaaat cctatggtga
     7801 ccggcgtggc attgaatgga aagaagtgct ggcaggagaa cgtgcctttc acgaaaccgg
     7861 ttcctggttg ccggacgaaa ccatggaagc cttccgcacc tataaggtgg gcatcaaagg
     7921 tcctttgaca actcccgtcg gcagaggtat ccgttccttg aacgtagcct tgcgtcagac
     7981 gcttgatttg tatgtctgcc aacgtccggt acgttggtat aagggtattg tttctccact
     8041 caaagagccg cagaaggtgg atatgtgcgt attccgtgag aataccgagg atatttatgc
     8101 aggcatcgaa tgggaagccg gaactccgga ggctgaaaag ttctatcgtt ttctccatga
     8161 tgacatgggg gtgacaaaag tccgttttcc cgaaacctcc tcgtttggcg tgaagcccgt
     8221 ttcaagagaa ggaacagagc gcttggtgcg tgccgcctgc caatacgcgc ttgagcatca
     8281 tctgccttcc gtgacgttgg tacacaaagg aaacatcatg aaatttacgg aaggcggctt
     8341 caagaagtgg gggtacgaac tggcagaacg tgagtttggt aaagagctgg cagaagggcg
     8401 tctggtcatc aaggactgca ttgccgatgc attcttgcag aacacgttgc ttatccccga
     8461 agaatattcc gtgattgcca cgttgaatct gaacggcgat tatgtgtccg accaactggc
     8521 tgccatggta ggcggcatcg gcattgcacc gggggcgaat atcaactata aaacgggtca
     8581 tgccatcttt gaggctactc acgggacggc tccgaacatt gccgggaaag acattgtgaa
     8641 tccctgttcc atcatccttt ccgctgtgat gatgcttgaa tatctgggtt ggaaggaagc
     8701 tgcctctctt atagagaaag ctttggagca gagtttcacc gaagcccgtg ctactgccga
     8761 cttggcacgt tttatgccgg gtggcgtctc gctgtccact tcgactttca cccgggagat
     8821 tgtaaggaga atagaaaatg ggaataacga ataaaacgaa acgattatga agaaggagta
     8881 cctgatttac aagctttccg aagatttgaa ggaagctacc cggattgaga atgaactgtt
     8941 caggaagttt gatgtgaagc gcggtttgcg taatgaggac ggcacgggag tcttggtggg
     9001 gttgaccaaa ataggcaatg tggttggcta tgaacgcatc cccggtggag ggctgaagcc
     9061 tattcccggc aaattgttct accgcggtta tgatgtggat gacttggcac acgccatcat
     9121 caaagagaag cgtttcggtt ttgaggaaat tgcctacttg ctgctttccg gtcgcctgcc
     9181 cgacaaggaa gaactctctt ctttccgtga actcatcaac gacaacatgc cgctggagca
     9241 gaagaccaag atgaatatca ttgaacttga aggaaacaac attatgaaca tcctggcgcg
     9301 cagcgtgctc gagatgtatc gttttgaccc tgatgcagat gacacttccc gcgataatct
     9361 gatgcggcag agcatcgagc ttatttcgaa attcccgacc atcattgcgt atgcctataa
     9421 catgcttcgc catgccaccc atggccgttc actgcatatc cgccatccgc aggaaaacct
     9481 ttccattgcc gagaatttcc tctatatgct gaagaaggac tacacggagc tggatgcccg
     9541 cacgctcgac ctgctgctgg ttcttcaggc cgagcacggt ggtggtaaca actccacttt
     9601 taccgtacgt gtcacttctt ctaccgggac ggatacttac tcttcgatag cggcaggtat
     9661 cggttccttg aaagggccgc ttcatggagg tgccaatatc caggttgccg atatgttcca
     9721 ccatctgcag gaaaacattc aggactggac gaatgtggat gagattgata cttacttcac
     9781 ccgcatgctc aacaaggaag cctataacaa gaccggcttg atatatggta tcggacatgc
     9841 cgtctatacc atttccgacc cgcgcgccat tctgctgaaa gagcttgccc gcgaccttgc
     9901 ccgcgaaaaa gggaaagaac gcgagttcgc tttccttgaa ctgctcgagg agcgcgccat
     9961 tgatgtgttt ggccgtgtga agaataatgg aaagacggtt tcgagcaatg tggatttcta
    10021 ttcgggcttt gtctacgaga tgattgggct gccgcaggaa atcttcacgc ctttgtttgc
    10081 catggcacgt attgtcggtt ggtgtgccca tcgcaatgaa gaattgaatt tcgaaggcaa
    10141 gcgtattatc cgtcctgcct ataagaatgt tttggatgag gtgacttatg tgcccattaa
    10201 gaaacggtaa ggattaaact tgtatctttt aaatcgttcc attacggggg aaaaatcgtt
    10261 ccaccatggt ggaacgattt tttctccatg gtggaatgaa ttttactcca tgatggaacg
    10321 attaggcttt tgtatctctg ctgcttaatc ctctcagtaa aaaacgctgg tttttgtatg
    10381 aaaaaacaat tttatccgga gaaaacgatt tgtttgttgt gagttttctt tatctttgct
    10441 tcgcataaat aaagaactat gaatcaggaa acttttcaga tatttctgtg ggtaatgagt
    10501 gctgtggcat tggctgtctt tattgcactc tattttgtca aggcaggcta tggcatgttc
    10561 cgtactgctt cgtggggaat ttccatcaat aataaactgg catgggtgct tatggaagcg
    10621 ccggtattca tcgtcatgtt tgggttgtgg gggaagagtg gagcgggatt taccgtgccg
    10681 gtatatttct tcttcctgct gtttcagttg cactatcttc agcgggcctt tatttttccg
    10741 ttcctgctga aaggtaaaag ccggatgccg gtagctatta tggcgatggg tatcgtcttc
    10801 aaccttttga acgggatgat gcaggcgggc ggtttgttct atttcgctct cgaaggcttg
    10861 tatgccgatg gctgggccta tttgttgaaa cctcatgcct tgttgggagt cattctgttt
    10921 tttgcgggta tgttcatcaa tttgcattcc gactatgtga tacgtcattt gcgtaagccg
    10981 ggtgatacga agcactacct tcccggaaaa ggactttacc gatatgtcac ttctgccaat
    11041 tacttcggtg agctggtgga atggactggg tttgccatac tcacagcttc ccctgccgct
    11101 tgggtgttcg tctggtggac gtttgccaac cttgttcccc gtgccgatgc cattcaccgc
    11161 cgttatcggg aggagtttgg cgatgaggcg gtaggaaagc gcaaacgcat cattccattt
    11221 ctttattaat ggaaaatgga aagttgaaaa tggaaaatga ataattcata acttataatt
    11281 cataactcat aactcataac tcataacgat ggaatccaag ttattcaccc ccgtcacttt
    11341 cggaccgttg accttgcgta accgtaccat ccgttcggct gctttcgaga gcatgtgtcc
    11401 cggaaacgct ccgtcggaca tgttgctcga ctatcatcgg tcggtagcgg cgggcggtat
    11461 aggtatgact actgttgcct atgcggcagt tactcagagc ggcctgtctt ttgaccgcca
    11521 gttgtggatg cgtcccgaga ttatccccgg actccgtagg ctgactgatg ccatacatgc
    11581 ggagggggct gcggcaggca tccagttggg acactgtggc aacatgtccc ataagagcat
    11641 ttgcggttgt atgcccgtcg gcgcatcttc cggtttcaat ctttactctc ctacctttgt
    11701 gcgcggactg cgtgccgatg agctgccgga gatggcgcgt gcttatgggc gttcggtgaa
    11761 tctggcacgg gaggccggat ttgattctgt agagattcat gcagggcatg gctatctcat
    11821 cagccagttc ttgtccccgt ccaccaacca tcggaaagac gagttcggag gctcgttgca
    11881 gaaccgtatg cgttttatgg atatggtgat ggaagaagtg atgaaggctg ccggcagtga
    11941 tatggctgtg ctggtgaaga tgaacatgcg cgacggtttc cgtggaggga tggagctgga
    12001 cgagacgatg caggtggccc ggagactgga gcagtcggga gcacatgcgc tggtcttgag
    12061 cggtgggttc gtcagtaagg cgccgatgta tgtcatgcgg ggcgaaatgc ctatccgcag
    12121 catgacgcat tacatgacct gctggtggtt gaaatacggt gtacgtatgg taggcaaatg
    12181 gatgataccg agcgtaccgt ttaaggaagc ctatttcctg gaagatgcct tgaaattccg
    12241 tgccgccttg aagataccgt tggtttatgt gggtggcctg gtttccaggg acaagataga
    12301 tgaggtgctg gatgacggct tcgaggctgt gcagatggcg cgtgccctgc tcaatgagcc
    12361 ggggtttgtc aaccgcatgc gtgccgaaga gaatgcacgt tgcaactgcc ggcatagtaa
    12421 ttattgcatt gcccggatgt attccatcga gatggcatgc catcagcatt tgaaggagga
    12481 gcttccacct tgtctgaaaa aggagataga gaaaatcgaa gcgaaaggct gatttttagt
    12541 ttttaatttt caatttttaa ttattaaagt gaatttagct gttataaccg gggcagacgg
    12601 tggcatgggc atggaaatta cccgcgcagt ggcaactgcc ggctatcagg tcatcatggc
    12661 atgccgtgac cctcaaactg ccgaacccaa gcggcaactg ctgatgcgtg aaaccggtaa
    12721 tccgcgtatt gagattgctc ccgttgattt ggcatctctg gcttcagtgg ccgcatttgc
    12781 agagcatctg ttgaagcggg gagagccgtt ggcattgctg atgaacaatg ccggaactat
    12841 ggaaacggaa cgccgcatta ccgaagacgg actggaacgg acggtgagtg tcaattatgt
    12901 agggccttac ctgctgaccc gcaagctgct gccattgatg ggagagggga gccgtattgt
    12961 gaatatggta tcttgtacgt atgccatcgg tcatcttgac tttccggatt ttttcctccg
    13021 gggaaagaag ggtggctttt ggcgcattcc tatatatagc aacacgaagc tggcattgac
    13081 tctgttcacc atcgacttgg ccagtcgcgt caaacacaaa ggtattgttg tgaatgcggc
    13141 cgacccgggg attgtgtcta ccaatatcat caccatgcat atgtggtttg acccgctgac
    13201 agatatactt ttcaggcctt ttatccgtac tccccgtaag ggagctgcaa cggctgtcgg
    13261 cttattgctg gatgaggatg ccggtaaacg tacggggaca ttgaatgcca gttgccgtcc
    13321 caagtctctt tcggagaagt acacccggca tgtacag
//
