LOCUS       c00070_gnlPro..        15330 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FKPBAAHO_70.
ACCESSION   c00070_gnlPro..
VERSION     c00070_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 00:14:00
            Original ID  :: gnl|Prokka|FKPBAAHO_70
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15330
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15330
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[467:5330]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      468..5330
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..15330
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15330
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(468..1292)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_1"
                     /sec_met_domain="ECH_1 (E-value: 2.4e-82, bitscore: 265.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYEDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKKYPKFP"
     CDS             complement(1296..2963)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.3e-08, bitscore:
                     23.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLEAHGITKVVLCPGSRNAPLVHTLSTHPGFT
                     CYAMTDERSAGYFAIGLALNGGHPAAVCCTSGTALLNLHPAVAEAYYQNIPLVVISADR
                     PAAWIGQMAGQTLPQPGVFQTLVKKSVNLPEIQTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINIPISEPLFQFTAESLPEVRVITRYQGLNVYDRDYNDLIERLNRYQKRMVIVGQMN
                     LIYLFEKRHTKLLYKHFVWLTEHIGNQTVPGIPVKNFDAALYAMPEEKIGQMTPELLIT
                     YGGHVVSKRLKKYLRQHPPKEHWHVSAGGEVVDLYGSLTTVIEMDPFEFLEKIAPLLDN
                     RVPEYPRVWENYCKTIPEPEFGYSEMSAIGALIKALPESCALHLANSSVIRYAQLYQVP
                     STIEVCCNRGTSGIEGSLSTAVGYAAGSDKLNFIAIGDLSFFYDMNALWNINVRPNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKYITAVHKTSAKGWAEERGFLYQRVENEEQLAEAM
                     KTFTQPEAMEQPVLMEVFSNKNKDARILKDYYHQLKQK"
     CDS             complement(2983..4095)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg70_3"
                     /sec_met_domain="Chorismate_bind (E-value: 1.4e-58,
                     bitscore: 188.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDEKSNLTTIDALILRKQPFAVYRVPGEKYPRLLTEDVGAVRLI
                     YDLKELNGQRGFVIAPFRVDKSCPIVLIQSDRTGRPLPMEIVADEEQVLQSYPEESFHT
                     LCTGKYATCFHTFIEALRDATFDKLVLSRSLTIRKNPEFSPSAVFRAACQRYIHSYIYL
                     CYTPQTGVWLGSTPEIILSGEKNEWNTVALAGTQPLQNGKLPQVWDDKNRQEQDYVASY
                     IRRQLLSLGIRSTESGPYPAYAGALSHLKTDFHFSLKDNKNLGDLLKVLHPTPAVCGLP
                     KEEAYRFILENEGYDRKYYSGFIGWLDPEGRTDLYVNLRCMHIEDEQLTLYAGGGLLAS
                     SELNDEWQETEKKLQTMRRILVSAPIMMNH"
     CDS             complement(4092..5330)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_4"
                     /sec_met_domain="HBT (E-value: 2.5e-17, bitscore: 53.0,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSMKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLAS
                     GRPTYGLMPLAKSLELGNYGGFILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARK
                     NNFALFTYHDDTIITDTPENEHIQNEARLNNLKVIKEEEFSVAIDFAPCKCMLVSDDEE
                     ALVSLEGHWKRRLNGALDVFRSEPYFLEVVPCAIDKANTLGALLEELDVKREEVIAIGD
                     GVCDVTMIQLAGLGVAMGHSQDSVKVCADYVTASNEEDGVALAVEKAIIAEVRATEIPL
                     DQLNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALGETVAGL
                     GSMILCQPDEIVVGMQVSGNHISSAHEGDTVRAVATIVHKGRSSHVWNVDVFTSTNKLV
                     SSIRVVNSVMKKR"
     CDS             complement(5409..5771)
                     /locus_tag="ctg70_5"
                     /transl_table=11
                     /translation="MVQVRIKRVYEDFSETDGYRVLVDKLWPRGIRKEWLKYDYWAKDI
                     TPSAALRRWFHEDIPGHWSDFVVMYQKELEASQAVADFLTLIKPHPVITLLYASKEPVY
                     NHARILRDYLEMHLKE"
     CDS             complement(5842..7611)
                     /locus_tag="ctg70_6"
                     /transl_table=11
                     /translation="MKSIRSVICFCLFLFVFNQLLFADKTIENDSLYTSEYISRIYMAE
                     PERALSLLDGAESKKTIPLRIIHELRSRVYRNMYMTKLAFLYAKKSYLLDSVSQKDPKH
                     LLTMTVDLAELAVLMSDHKESMRYALDGIKLAQKEKDKGAESKLLFCIGENKWQLSFKE
                     EAYDYFDKAIKLLQGTSSKLEMAMLSYFYGMKMDYLLNDSRSKEALEVGLKREKLLKDI
                     AKLPEKTKGFLDLQYTYLYAKMSYICYLEGKYDQAEKYYQQYLSTENSQTPDGKTYAIP
                     YLLVSKQYQKVVDQCQDFKKLMQEQDTVNLQYISILQKEVKAYKGLKDFEKVAALRESI
                     ISIIDGINSKDKQNAALELNAIHKADEQEEYIAEQTLQLRIRNISLAFLGCVTCLILFV
                     LWRIWRHTIIVKYKNKMLAKFINEKLAGKVENKQLFIDGDAEDPIAVPLDLEPETGFSE
                     KDDLSPDEVVESREEEDENKKIFKELNRIVVQDQLYLSPELSREDLAQIVHLNNARFAR
                     MIKENTGTNFNGYINELRINYAIQLLKQHPNYTIRAIADEAGFNSTPILYSMFKKKTGM
                     TPYEFKKAQESLG"
     CDS             complement(7990..8757)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg70_7"
                     /sec_met_domain="Acetyltransf_1 (E-value: 4.1e-08,
                     bitscore: 23.4, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAKYITLTKENIEKEHICCAFSDKKCKDSYELKKTWLKNEFENG
                     YVFRRLDERAKVFIEYGPAEKAWVPVNAPNYLMINCFWVSGKYKGCGHGKALLQSAVED
                     AKAQGRDGLVTVVGTSKFHFMGDAKWLLRQGFETIEKLPYGFSLLALKINPAAPDPSFN
                     GTVSSGECEEKEGVVVYYTHRCPFAEFHVRNSLVSVTENKGIPLKIVRLETMAQAQNAP
                     TPATIFSLFYKGKFVTTDLSACMEQRFDKALGL"
     CDS             complement(9094..10344)
                     /locus_tag="ctg70_8"
                     /transl_table=11
                     /translation="MKKNIRYNIVLLLLMVEAVLIPAFAQMPEIKLGQSISFEEYLNRV
                     AKKNLSYLAEKLNVSIADAEVIARKIFPDPELEFEAGNETFSLGVSYSLEMGNKRGARI
                     KLARTQAELEKLFLQQGFQDLRAEAADLFLEAILQRELLEVQKSSYEYMYQLSQSDSLR
                     YVSGEITENDVRQSKLETVTLLNTVYSQEAAYHSALVLLNKHMGMSADTLHIPLGNWEE
                     LSRDFALSDLVKAGLDNRIDLLVAQKSTEVTTREYKLTRAERRPDIGVSVSYERNWNGF
                     LPPSRSATAGVSVPLTFSNINKGAVKAAKFRIAQSEIMERDMELQIQAEITQAWFNYEA
                     EKKKIAQYKAGVLEDSQKVLDGMVYKYKRGETSILDVLVAQRTYNEVQQEYLETMKGYA
                     ASLVALERACGIWDICF"
     CDS             complement(10322..13429)
                     /locus_tag="ctg70_9"
                     /transl_table=11
                     /translation="MKKELMLSIIQKRWVMLCLFVMMCIFGYYSWKQLSIEAYPDIADV
                     TSQVVTQVPGLAAEEVEQQITIPLERAINGLPGMHVMRSKSTFGLSMITIVFKDGTEDY
                     WSRQRVQERLNEVELPYGAVPGLDPLTSPVGEVYRYIIESDQHSLRELTDLQNWVIIPR
                     IKEVSGVADVTNFGGITTQFQVEVDPSKLEQYNLSLSQVVEAIENNNANVGGSVLNRGD
                     LGYVVRGIGLIGNLDDLGHIVVSTTSGVPVFLNDIGSLKYGNLERKGVLGYTDRTRNYS
                     ESLEGIVLLLKHENPSKVLEDIHVAVDELNNETLPEGVRIHTFLDRTNLVDTTLSTVSH
                     TLLMGMALVVLVLILFLGNWRGALLVSITIPVSLLIAFILMHLTDIPANLLSLGAIDFG
                     IIVDGAIVMLETILKKREDNPKQYLEEKSMAQRAKEVGRPILFSTIVIITAYLPLFAFE
                     RVERKLFTPMAFTMSYAMIGALLVALLLIPGLAYAIYRKPHKIYKNKWLDRLKDKYIRT
                     ITGFLEAPLKAIISSGLILTAGIVLSVVVGKDFLPELDEGSIWLQVNLPPGISVEKSRE
                     LSDTLRARTMKYSEVTYIMVQAGRNDDGTDPFTPSHFEVSIGIKPYDEWPKGKTKKDLI
                     HELEEEYKLLPGFKVGFSQPMIDGVMDKIAGAHSELVVKVYGEDFRETRRIAEEITKAL
                     GTVRGAVDLDIDQEPPLPQLQISMNRDAIARYGLNVSDVADLIEVAVGGKAIAQLYQGD
                     RQYGITCKYKEEARNTPEKIAGLMLTSSTGAKIPLSQVADVRLSVGESTITREMNRRHL
                     TVKLNLRGRDLTSFLNEAQNTINEKVHYDKNKYTIKWGGAFENQKRAYTRLAVIIPLTL
                     TGMFILLYVTFGKFRQAGLVLAIVPLALFGGMLALNVRGMTLNVSSAVGFIAMFGLSIQ
                     NGIIMVSQVNGLRRGGMELRKSVIEGARQRFRPILMTSVTTILGLFPASLATGIGSDVQ
                     RPLATVIVYGLMFSTLISMFLLPAFYYLVENNVLNKKKNDEKEYTI"
     CDS             complement(13436..14545)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg70_10"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 7.1e-10,
                     bitscore: 28.6, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMMKRELHTFIIGSVLFFTACGDKQESEQKSGYRIQGDTVYIADP
                     LLLEKIKVSVSELKPYSKKVITSGVVRPIPPRYAYVAPPFAGRVTKSYVRIGQSVRQGT
                     PLFEISSPDFTSAQKEYFQALSSRELAKKDLKRKEDLIRNGVSSQRELEEAQNALLIAD
                     KEFENASAALRVYQVDNPAEMILGQPMIVRSPIPGEVIKDNIVTGQYLKDDTEPIAIVA
                     DLSKVWIAAQVKEKDIRFINEGSSLDIEISALPGTVIKGNVYHVEEEVDEETRSIQVLS
                     VCDNLNGHLKLGMYTTVHFLSVPVGQIQIPEKTLLQGEKDSYVFVQIAPLVFVRTSVTV
                     ETTENGIAVISEGLRPGDKIISEGGYYLK"
ORIGIN
        1 atcttcaact ttatacagcg gaatcccgcc tccatcttct tctctatctg agcaagcatt
       61 ctattgaagt cacccatcca gataagcccg tttatcggaa tacctgcttc cccacgtgag
      121 aagggtgtat cccacaaagc ccagcttcct tcaaaaaagt gacgaatggc tgtctccaag
      181 ccaaaaagga tggaagggta cttgcataga gcttccatgt ccagcttacc tccctgattc
      241 tctacctgcc ggcagatttt agccagcact tcctcgtaat cgggaagatc atcacagcta
      301 agatttggca gaggagcgca ctccccgatc cctacccaat tgggaaattc gggagcagta
      361 aaatgaagat accagacttt tcgcgttgtg tatgtgcctc gtgaagttcc ggccggctgc
      421 ttgaaatgaa gcacccgcgg aataatgtct attttgcaat ccattgttta agggaacttc
      481 ggatatttct taaagttagg tttacgtttc tccagaaatg cattctttcc ttcctgagcc
      541 tcatccgtca gatagtaaag caaggtcgca tcccctgcca gctcctgaat acctgcctgg
      601 ccgtccagtt cggcattcaa tccggcttta atcatccgca aggccaacgg actgagcagc
      661 atcatttctt ccgcccattg cacatactca tcctccagtt gctccaatgg aactacttta
      721 ttcaccaatc ccatatccaa cgcttcctgc gcattgtatt tccggcaaag gaaccatatc
      781 tcacgtgcct tcttctgacc gacgacacga gccagataag aggctccgaa acctgcatca
      841 aagctaccta cgcgaggacc ggtctgtccg aagatcgcat tctccgaagc aatcgataaa
      901 tcgcaaacta catgaagcac gtgtccgcca ccaatggcaa atccatttac ggcagcaatt
      961 accggtttcg gaatgctgcg gatttgtttc tgtacatcca gaacactcag acggggaaca
     1021 ccgtccttgc cgatatagcc gccacgccct ttcacattct ggtcaccgcc cgaacagaaa
     1081 gccttgtcac cagctcccgt aatcacgatc acatcaatat ccgcttcttc ccggcaaatg
     1141 cgcaatgcgt cactcatttc agccgttgta gtcggagtaa atgcatttcg atagcgttca
     1201 cggttaatgg tgatgcgggc aatcccatta tagtaatcaa agaggatatc ttcgtattct
     1261 ctgatggttg tccattctct ttgtgttgac ataatctatt tttgttttag ttgatgataa
     1321 taatctttca gtatacgtgc atctttattt ttattgctga atacttccat cagaaccggt
     1381 tgttccatgg cttccggttg tgtgaaggtt ttcatcgctt cggcaagctg ttcttcattc
     1441 tctacccgtt gataaaggaa tccgcgttct tccgcccatc ctttggcaga tgtcttgtga
     1501 acggctgtaa tatacttgtg cgatgtaccc gacatatcca gtccgggtaa tgtatggaaa
     1561 atctcccctc ctccgttatt cagcaaaaga atgcgtagat tgggacggac attgatgttc
     1621 cacaaagcat tcatatcata aaagaaacta aggtcaccta tagctataaa atttagttta
     1681 tccgaaccgg cggcatatcc cactgccgtg gacaacgagc cttcgatgcc acttgtaccc
     1741 cggttacaac atacctcaat cgtagaagga acctggtata actgagcata gcggataaca
     1801 gaactatttg ccagatgcaa tgcacatgat tccggcaatg cttttatcaa agcaccgata
     1861 gccgacattt ccgaatatcc gaactccggt tcgggaatgg tcttgcaata attctcccat
     1921 acacggggat actccggcac gcggttatcc agcaatggag ctattttctc cagaaactca
     1981 aacgggtcca tttcgatgac ggtagtcaga gaaccgtaaa ggtcaaccac ttctccacca
     2041 gcagacacat gccaatgttc tttaggcgga tgctgccgaa gatatttttt caaccgcttg
     2101 gaaaccacat gtccgccata agtaatcagt agttcgggag tcatctggcc gattttctct
     2161 tcgggcatcg cataaagcgc cgcatcaaaa ttcttcaccg gaataccggg tactgtctga
     2221 ttaccgatgt gctcggtcag ccacacgaaa tgtttatata acaatttggt atgccgtttc
     2281 tcaaacaagt aaatcaagtt catctgtccg acaataacca tccgcttctg atatctgttc
     2341 aagcgttcga tcaggtcatt gtaatcccgg tcgtatacat tcagaccctg atagcgcgtg
     2401 ataacacgta cttcgggaag cgactccgcc gtaaactgga acaaaggttc ggatatagga
     2461 atattaatat gtaccggacc ttttccatga tggttggttt ccagcaatgc ttcattcacc
     2521 aagcggttac agtaccattc atcctcttct gtctgaatct ccggaaggtt taccgatttc
     2581 ttgaccaatg tctgaaaaac accgggctgc ggcaatgtct gtcccgccat ctgtccaatc
     2641 caggcagcag gccgatcggc agagatcaca actaaaggta tattctgata atacgcttct
     2701 gccacagcag gatgaagatt gagcaacgct gtaccggaag tacagcaaac ggcagcagga
     2761 tgcccgccat tcagcgcaag accaatcgca aaataaccgg cactccgctc atccgtcata
     2821 gcataacaag taaaacccgg atgagtagac agcgtatgca caagaggtgc attacggcta
     2881 ccgggacata acactacttt cgtaattcca tgcgcctcaa gcaacgcgac caactggagt
     2941 atatttttct tgtccgaata catattaata gtgattagct tgttaatgat tcatcattat
     3001 tggagcagac acaagaatac gcctcattgt ctgcaatttc ttttccgttt cctgccattc
     3061 atcattcaac tctgaagagg ctaacaatcc gccaccggca tacagtgtca gttgctcgtc
     3121 ttcaatgtgc atgcaacgca gattcacata caaatctgtg cgtccctccg gatcgagcca
     3181 accgataaaa ccggaataat acttacgatc gtacccttca ttttccaaaa tgaaccggta
     3241 ggcttcttct ttaggcagtc cgcacacggc aggagtcgga tgcaggactt tcagaaggtc
     3301 tcccagattt ttattatctt tcaaagagaa atgaaaatca gttttcagat gtgacagggc
     3361 gccggcatat gccggataag gcccgctctc tgtagagcga atgcccagcg aaagaagctg
     3421 ccgacggata taggacgcca cataatcctg ctcctgacgg tttttgtcat cccatacttg
     3481 cggaagttta ccattctgca aaggttgagt tcctgccaag gcaactgtat tccattcatt
     3541 tttttcgccc gacaatataa tttcgggggt acttcccagc cacacgcccg tctgaggagt
     3601 ataacacaga tagatataag aatgaatata acgttgacaa gctgcacgaa aaacagctga
     3661 aggggaaaac tccggattct ttctaatagt gagactacgg gaaagcacca gtttatcaaa
     3721 ggtagcatca cgcaaggctt caataaatgt atgaaaacag gtcgcatact tccctgtaca
     3781 aagggtatga aaagattcct ccggataact ttgcaagacc tgctcttcgt ctgccacgat
     3841 ttccataggc aacggccgtc cagtcctgtc ggactgtatc aacacaatcg ggcatgactt
     3901 atctacacgg aacggagcaa tcacaaatcc tctttgtcca ttcagttctt tcaaatcgta
     3961 aatcaggcgg acagctccga catcttcagt caacagacga ggatacttct ccccgggaac
     4021 acgataaaca gcaaagggct gtttccgcag aatgagtgca tcaatagttg tcaagttact
     4081 tttttcgtca atcatctttt tttcatcaca ctgttgacca cccgtataga ggacaccagt
     4141 ttattggttg aagtaaaaac gtccacattc catacatggg aggaacgtcc tttgtgtaca
     4201 atcgtcgcta ctgcacgtac tgtatcacct tcgtgcgcag aagatatatg atttccgctg
     4261 acctgcattc ctaccacaat ttcatccggc tgacagagaa tcatcgagcc gagtccggca
     4321 actgtttctc ccaatgcaag cgtagctcca ccgtgcaaaa taccgaacgg ctgacgggta
     4381 cggtgatcta ccggcatcgt cgcctctaca cggtcttcgt cggcatatgt atattggata
     4441 cccagattac ccatcaatgc gtgacgcgcc tgtgcattca actggtccaa aggaatctct
     4501 gtagcccgaa cttccgctat tatcgccttt tcgacagcca gagccactcc gtcttcctca
     4561 ttggaagctg tcacataatc cgcacagacc tttaccgaat cctgcgaatg ccccatcgcc
     4621 actcccagtc ctgccagctg aatcatcgtt acatcgcaca caccgtctcc tatagcgatg
     4681 acttcttcac gcttcacatc cagttcttcc aataaagctc ccaatgtgtt ggctttatca
     4741 atcgcacacg gcactacttc cagaaaataa ggttcggaac ggaaaacatc caaagctccg
     4801 ttcaaccgtc tcttccagtg tccttccaga ctaaccaacg cttcctcgtc atcgctgaca
     4861 agcatacact tacacggggc aaaatcaatt gctacagaaa attcctcttc cttgatcact
     4921 ttcaaattat tcaagcgagc ttcattctgg atatgttcat tctccggagt gtcagtaatg
     4981 atcgtatcat catggtaagt gaacagtgcg aaattatttt ttcttgcctt cttttccaga
     5041 taaggcaaca tttccggatt aatcctccgc tcaaacagta tttctccgtt ttgagcatta
     5101 attatctggc aaccattata agaaagaata aaacctccgt aatttccgag ttcaagggat
     5161 ttggctaagg gcatcagacc gtaagtaggt ctgccggatg ccagcacgat acgtactccc
     5221 atttgctgta ctttcagcaa agcggccaat gtacgtttac taatttcttt tgcatcattg
     5281 agaagcgttc cgtctacatc aagaactaat aatttatact tcatggacac acgattttga
     5341 tttagattac aaaggtagga aattgagtga acgactgaaa gcggaaagag ataaaaatta
     5401 ctttaatttc actctttcag atgcatttcc agataatcgc gaaggattcg ggcatgattg
     5461 tagaccggtt ctttggatgc ataaagcaaa gtgatcaccg gatggggttt gataagagtc
     5521 agaaaatcgg caacagcctg agaagcttcc agttccttct gatacattac gacaaagtcg
     5581 ctccagtgcc ccggaatatc ttcatgaaac catctacgca gtgctgcgga aggcgttata
     5641 tcttttgccc agtaatcata tttcaaccat tctttcctga ttccacgtgg ccagagttta
     5701 tctaccagca cccgatatcc gtctgtctct gaaaagtctt cgtacactcg ctttatccta
     5761 acttgcacca tttccgttta tatttagtta tcataagaat aaaccgataa aacggaaaat
     5821 tgtttaacga aaaagccaaa atcaacctaa ggattcctgc gctttcttaa attcgtaagg
     5881 agtcatacca gtctttttct tgaacatact gtacagaata ggcgtactat taaatccggc
     5941 ttcatcagct atcgcacgaa tggtataatt gggatgttgc ttcaataact gaatcgcata
     6001 gttaatacga agttcattaa tatacccgtt gaaattagtt ccggtgtttt ccttgatcat
     6061 ccgggcgaaa cgcgcattat tcaaatgtac aatctgagcc agatcctctc tcgacaactc
     6121 cggagacaga tataactgat cctggacaac aatacgattc agttctttga aaattttctt
     6181 attctcatcc tcttcctccc tactctccac tacttcatcc ggagataaat cgtctttttc
     6241 ggaaaagcca gtttccggtt ccaagtccaa tggaacagct atcggatctt ccgcatctcc
     6301 atctatgaat aattgtttgt tctctacttt tccagccagt ttctcattga taaactttgc
     6361 cagcattttg tttttatatt taacaataat cgtatgacgc caaatccgcc atagcacaaa
     6421 taaaatgaga caagtgacac atcccaaaaa agcaagtgat atgtttctga ttcttaactg
     6481 taaagtctgt tcggcaatat attcttcctg ctcgtcagct ttatgaatag catttaattc
     6541 caaagccgca ttctgtttat ccttgctgtt aataccatca ataatagaaa taatagactc
     6601 acgtaatgct gctacttttt caaaatcctt caagccttta taagctttca cctctttctg
     6661 aaggatacta atatactgca agttgacagt atcctgctct tgcatcaatt tcttaaaatc
     6721 ctgacattga tcaacgactt tctgatattg tttagacact agcagataag gtatcgcata
     6781 ggtttttcca tccggtgtct gtgaattctc tgttgacaaa tattgttgat aatatttttc
     6841 cgcctgatca tactttcctt ccagatagca gatatacgac atttttgcat acaagtaagt
     6901 atattgcaga tcaagaaagc cttttgtttt ttccggtaat ttagctatat ctttaagtag
     6961 cttttcgcgc ttcaacccaa cctccaatgc ttctttacta cgggaatcat tgagcagata
     7021 atccattttc atcccataaa agtatgaaag catagccatt tccaatttgg aacttgtacc
     7081 ttgaagcaat ttgatagctt tgtcaaaata gtcatatgcc tcctctttga aagacaattg
     7141 ccatttattt tcaccaatgc aaaacaacag cttactttca gcccctttat ccttttcttt
     7201 ttgtgctagc ttgataccat caagagcata cctcatactc tctttatggt cactcataag
     7261 cactgctaat tctgccaggt cgacagtcat ggtcaacaag tgcttaggat ctttctgaga
     7321 aacggaatcc agcaaataag actttttggc atacaaaaaa gccagtttag tcatatacat
     7381 attacgataa accctgctgc gtaattcatg tataatacgc agagggatag tcttcttact
     7441 ttcagctcca tccaacaaac ttaaagcccg ttcaggttct gccatataaa ttcgacttat
     7501 atactcactg gtatatagcg aatcattctc tatagttttg tcggcgaaaa ggagctggtt
     7561 aaacacaaac aaaaacaaac aaaaacaaat aaccgagcga atacttttca ttataatccc
     7621 aatgatttta ctccccaaaa gtaaaacata gtttcataaa atgcaagaat tgaacatatt
     7681 tgaatgaact aaaataagaa aagttagtga ttataaaagt caggagccat caagttttcc
     7741 ccaccaacca catacaataa aatactaaaa atcaagcata tgtcacatac ataaaacaaa
     7801 acatctcaac atataaataa actgccgatt ctattaatga atctgcataa gatcagagca
     7861 gcacatgaaa aatcgaaccg accagtctaa ataaacacca gacaattatt aacccgccac
     7921 actcatcaga gcaaaacagc acaaaaacag aaaatcaaaa aagagaaaca catactgtaa
     7981 taagaaagat tataatccca acgctttatc aaaccgttgc tccatacatg cactcaaatc
     8041 cgtcgttaca aactttcctt tatagaaaag agaaaagata gtagcaggtg taggtgcatt
     8101 ttgtgcttgt gccatcgttt ccaatctgac tatcttcaat ggaatacctt tgttctcagt
     8161 cacactcact aaagaattac ggacatgaaa ctctgcaaac ggacaacgat gtgtataata
     8221 aacgactaca ccttcttttt cctcacattc tccacttgat actgttccat tgaatgacgg
     8281 atcaggagct gccggattta tcttcaaagc caaaagactg aaaccatagg gtagtttttc
     8341 tatcgtctca aacccctgac gtaataacca tttcgcatca cccataaaat gaaatttaga
     8401 ggtaccgacc acagtcacca agccatccct accctgtgct ttggcatcct cgacagcaga
     8461 ctgcaatagt gctttgccat gcccgcatcc tttatatttt cctgaaaccc aaaaacagtt
     8521 tatcattaaa tagttaggtg cattaaccgg aacccaagct ttttcggcag gtccatattc
     8581 tataaatact tttgcacgtt cgtcaagccg tctgaaaaca tagccattct caaactcatt
     8641 tttcagccat gtctttttca actcatagct atccttacat ttcttatcgg agaaagcaca
     8701 gcaaatatgt tctttttcga tattctcttt agtcagagtg atatacttcg cttccataat
     8761 attctgttta ttagtatata aattccggtt gtccatttta actacagcaa agatacacaa
     8821 tcgaaagtaa taaaacattg tccagtctcg tcaaaatgac acagtagtac ggattaaagt
     8881 tcggaaaaca gataagtaaa taaacctgag tgacaaactt atcaaagaac ttattgacca
     8941 ctctgtggaa gaagtgatca aaaaaactcc ctaagaaaaa acaggaggaa tatcgcacaa
     9001 tgatttaaca taaagcgtga aaccgctgac tggtaaccat acaaatatcc ggctttgctg
     9061 caattcacaa tagtaaagcc ggatatttaa ctgtcaaaag catatatccc atataccaca
     9121 agctctttcc aatgctacta gtgaagcggc atatcctttc attgtttcca gatactcctg
     9181 ttgcacttca ttataagtac gctgggcaac cagtacatca agaatactcg tttctccccg
     9241 tttgtattta tataccattc cgtcgagcac cttctgcgag tcttcaagta caccggcttt
     9301 atattgagct atctttttct tttcagcctc atagttgaac caggcctggg ttatctctgc
     9361 ctgtatctgc aattccatat ctctttccat tatctccgat tgggcaatcc gaaactttgc
     9421 agcttttaca gctcctttat ttatattcga gaatgtcaga ggaacagata caccggcagt
     9481 agcagaacgg gacggaggaa gaaagccgtt ccagtttctt tcataagaaa cagatactcc
     9541 gatatcgggt ctgcgttccg ctctcgtcag tttatattcc cgggtagtaa cttcagtact
     9601 tttttgagca acaagcaggt cgatgcgatt atccagtccc gctttgacca aatcagacag
     9661 agcaaagtcc ctgcttagct cttcccaatt tcccaaaggg atatgaagcg tatcagcact
     9721 catccccatg tgtttattca acaaaaccaa agcggaatga taagccgcct cctgactgta
     9781 aacagtatta agcaaggtga cagtttccag ttttgactgc cggacatcat tctccgtaat
     9841 ctctcccgaa acataacgta aactatctga ctgactcagc tgatacatat actcataaga
     9901 acttttctgt acttcaagta attcgcgctg aagaattgct tctagaaaaa ggtcggcagc
     9961 ctccgccctc aaatcctgaa agccctgttg caggaacagt ttctccaatt ctgcctgagt
    10021 ccgcgccaac ttaatacgtg ctcccctttt atttcccatt tctaatgaat aggaaactcc
    10081 caacgagaaa gtctcattac ctgcttcaaa ttccaactcc gggtccggaa agattttccg
    10141 ggcaattact tccgcatcag caatactcac attgagtttt tcggctaaat aactcaggtt
    10201 ctttttcgct acccgattca gatattcttc gaaagaaata gactgcccca gctttatttc
    10261 aggcatttgc gcaaaagccg gaatgagtac ggcttccacc attaacagca agagcactat
    10321 attatatcgt atattctttt tcatcgttct tctttttatt taaaacattg ttctcaacca
    10381 gataatagaa agccggaagc agaaacatag agataagggt tgaaaacatc aatccataca
    10441 caatcactgt tgccagcgga cgctgtacgt cactaccgat tccggttgcc aacgaagccg
    10501 ggaaaagtcc gagtatcgta gtgaccgaag tcatcagaat aggtcggaaa cgctggcgtg
    10561 ccccttctat gaccgatttc cggagttcca ttcctcccct gcgcagccca ttgacctgcg
    10621 ataccatgat aattccattt tgtatggaaa gcccgaacat cgctataaat cctacggcag
    10681 aagatacatt cagcgtcata ccacgcacat taagagcaag catacctccg aaaagtgcca
    10741 gaggaacaat agccaatacc agtcctgcct gccggaactt cccgaacgtg acataaagca
    10801 gtataaacat ccctgtcagt gtcagcggta taatgacagc aagacgtgta taagcccgtt
    10861 tttgattttc gaaggcccct ccccatttga tggtatattt attcttgtca taatgtactt
    10921 tctcattgat cgtattctgg gcttcattca gaaaagatgt caggtcacga ccgcgcaaat
    10981 tcagctttac cgtcaaatgg cgtctgttca tttccctggt aatcgtactt tcgccgacac
    11041 tcaatctgac atcggcaacc tgagaaagag gtatctttgc accggtggaa gaagtcaaca
    11101 taagtccggc tattttctcc ggagtattcc gcgcttcctc tttatactta caggtgatgc
    11161 catactggcg gtcaccctga taaagttgtg cgatagcttt acctccgaca gccacttcaa
    11221 tcagatccgc tacatcggat acatttaatc cgtaacgagc tatggcatca cgattcatac
    11281 tgatctgtaa ctgtggcaag ggtggttcct gatcaatatc cagatcaaca gcccctcgca
    11341 cagttcctaa tgccttggtt atttcttcgg caatacgacg tgtttcacga aaatcttcgc
    11401 catatacttt caccaccagt tcactatggg ccccggctat cttatccatc accccgtcta
    11461 tcataggttg gctaaatcct actttaaaac cgggaagtaa cttatattct tcttccagtt
    11521 catgaatcaa atccttttta gtttttcctt tcggccattc atcataaggc ttaataccga
    11581 tggacacttc aaaatgtgaa ggggtgaacg gatcagttcc gtcgtcattt cttcccgcct
    11641 gtaccataat ataagttact tcggaatact tcatcgtacg ggcacgcaaa gtatcggata
    11701 actcccgtga cttttctacg gaaattccgg gtggcagatt aacctgtaac catatcgaac
    11761 cttcatccag ctccggaagg aagtcttttc ctacgacaac actcaacacg atccccgctg
    11821 tcagaatcag tcctgatgaa atgatggctt ttaagggagc ttccagaaat cctgtaatgg
    11881 tacgaatgta tttatccttt agtctgtcca gccatttatt cttatatatt ttatgtggtt
    11941 tacgatagat tgcataggca agtcccggaa tcaataagag cgcaaccaac agtgctccaa
    12001 tcattgcata gctcatcgta aatgccattg gagtaaaaag tttgcgttca acacgttcaa
    12061 aggcaaacag cggaaggtat gccgtaataa tgacaatggt tgagaaaaga ataggccgac
    12121 ccacttcttt ggcgcgttgc gccatgcttt tttcttcgag atattgtttg ggattatcct
    12181 cacgtttctt aaggatcgtt tccagcataa cgatagcacc gtccacaata ataccgaaat
    12241 caatagcacc aagcgacaga aggttagccg gaatatccgt cagatgcata agaataaaag
    12301 cgataagcaa tgacacagga atcgttatag ataccaataa tgcaccacgc cagttgccta
    12361 gaaacagaat aagcacaaga accaccaaag ccatacccat cagcaaggta tgggatacgg
    12421 tactcaaagt agtatccacc aagttggtac gatccagaaa agtatgtatc ctcactcctt
    12481 ccggcaatgt ctcattattt aactcatcaa ctgccacatg aatatcttcc agtactttag
    12541 acggattctc atgtttcaga aggagtacga ttccttccag actctcagag tagttgcggg
    12601 tacggtccgt atatcccagc actccctttc tttcaagatt tccatacttc aaagaaccta
    12661 tatcattcag aaagacagga actccggaag tagtactcac tacaatatgt cccaaatcgt
    12721 ccaaatttcc gattaatcca attccccgta ccacataacc caagtcacca cgattcaaca
    12781 cgcttccccc cacattggca ttgttattct caatggcttc aacaacctgg ctgagagata
    12841 aattatattg ttccagtttg gacggatcta cttcaacctg gaactgagta gtgatcccac
    12901 cgaaattggt tacatcagcc actcccgaca cttccttgat acggggaata attacccagt
    12961 tctgaaggtc ggttaattcg cgtaatgagt gctggtcact ttctatgata taacggtaca
    13021 cttctcctac gggagatgtc agcggatcaa gtcccggaac agctccataa ggcagttcta
    13081 cttcattcaa tctttcctgt acgcgctggc ggctccagta gtcctctgtc ccgtccttaa
    13141 agacaatggt aatcattgac agcccgaatg tactcttact ccgcatgacg tgcataccgg
    13201 gcagcccatt aatagcgcgt tccaaaggaa tggttatctg ctgttccact tcctccgcag
    13261 ccagtccggg aacttgagtg accacctggg aagtgacatc tgcaatatcc ggatatgctt
    13321 ctatcgaaag ctgtttccat gagtaatatc caaagataca catcatcaca aacaggcaaa
    13381 gcattaccca tcttttttgt ataattgaaa gcattaattc cttcttcata atttcttact
    13441 ttaaataata tcctccttca ctgattatct tatctccggg acgcaatcct tcgctgatca
    13501 ccgctattcc gttttctgtt gtctccactg tcaccgacgt ccgtacgaaa accaacggag
    13561 caatctgcac aaatacatag ctatcctttt cgccctgtag taacgttttc tccgggattt
    13621 gaatttgtcc gaccggaaca ctcagaaagt ggacagtagt gtacatcccc agcttcagat
    13681 gtccgttcaa attatcacag accgaaagta cctgaatgga ccgggtttcc tcgtctacct
    13741 cctcctctac atgatacaca ttgcctttaa taaccgtacc gggcaatgcc gaaatttcaa
    13801 tatccagact actgccttca tttataaacc ggatatcttt ctcctttacc tgagccgcaa
    13861 tccatacctt agacaggtcg gcaacaatag ctatcggttc ggtatcatct ttcagatatt
    13921 gccctgttac gatgttatcc tttatcactt ccccgggaat aggagaacga acaatcatcg
    13981 gttgccccaa tatcatttcc gccggattgt ccacctgata tacccgcaat gcggcagagg
    14041 cgttttcaaa ctccttatct gctatcaata aagcattctg ggcttcttcc agttctcttt
    14101 gcgaactgac accattcctt atcagatctt ctttgcgttt caaatctttt ttagcaagtt
    14161 ccctggacga aagtgcctga aagtattcct tttgtgcaga agtaaagtcg ggggaactga
    14221 tttcaaataa aggtgttccc tgacgtaccg actgtccgat acgcacataa gattttgtga
    14281 ctctccctgc aaatggagga gcaacataag cataacgggg aggaatggga cgcaccacac
    14341 cggacgttat caccttcttg gaatagggtt tcagttcaga cactgatact ttgatctttt
    14401 caagtaaaag aggatctgca atatagaccg tgtcaccttg tatacgatag ccactttttt
    14461 gctctgattc ctgtttatcc ccgcatgcgg taaaaaacaa cacactgcca ataataaatg
    14521 tgtgtaactc tctcttcatc atcataatta aacataagtt aagttagtaa ccggatttcc
    14581 gggcacaaag atagacggct cccttcggag agcctgttag agaatagtta gaatcctatt
    14641 agaatcttat tagagtaaat aaagatttct tcttaaaaca gcagttttgt tgttagagag
    14701 tacgcacaaa taaggggttg actaaaaagc caacccctca acggatgata ttccggtatt
    14761 tttatcgtaa gccgaaaagt tcttattctt tcacacaacg tatactttga gcaaaacctt
    14821 gatatgacaa tctgaaatta tgagaattat atgcagactc aagcgaccag gctccataac
    14881 gtattctcct gtcataaggt ggattctgca attccgatct catataagga ggacctacac
    14941 ttgccgacca atagtatccg gtactacccc tactttccaa agcaccactt gtgttattca
    15001 gacgaccggc tgacggaaaa aagacagatg cattcgttcc ggaatcggga ttaaaataca
    15061 atactccctg ataagcaaca ttactatttc ctaatgatac gccatagttt ccattcgaag
    15121 cctcttttat cggacgtctg tcgaaaaatc cgtccgaata aaatgtataa gttgttcctt
    15181 ttagttgttt ccgggcaagc atatctttgt ttgctccgta aggatatgtc ccaggacctg
    15241 tattaccagt tccaccaaaa ggagtagtaa aagctgtagc gtagtctgca cttgaagccg
    15301 catttcctgc aaaaggtaca ttaaataaag
//
